August 19th 2015
Histone lysine and arginine methyltransferases
9:00 - 9:25 Dr. Cheryl Arrowsmith (University of Toronto, Canada); Welcoming Remarks
Keynote Speaker:
9:30 -10:20 Dr. Richard Chesworth (Epizyme, USA)
The discovery and development of EZH2 inhibitor EPZ-6438 and
Identification and Optimization of First-In-Class PRMT5 Inhibitor EPZ015666 (GSK3235025)
10:30 - 10:45 Coffee Break (Provided by Tocris Bioscience)
Chairperson: Dr. Cheryl Arrowsmith
10:45 - 11:10 Dr. Patrick Trojer (Constellation Pharmaceuticals, USA)
Targeting histone lysine methylation in cancer
11:15 - 11:40 Dr. William Pappano (AbbVie, Chicago, USA)
Discovery of A-196, a novel chemical probe for SUV420H1/H2
11:45 - 12:10 Dr. Robert A. Rollins (Pfizer, NY, USA)
Epigenetic reprogramming in cancer cells by the EZH2 methyltransferase
12:15 – 12:40 Dr. Marion Hitchcock (Bayer, Berlin, Germany);
Discovery and Characterization of Aminopyrazoline-based SMYD2 Inhibitors
12:45 - 1:30 Lunch
Chairperson: Dr. Peter Brown
1:30 - 1:55 Dr. Matthieu Schapira (University of Toronto, Canada);
Structural chemistry of protein methyltransferases
2.00 - 2:25 Dr. Jian Jin (Icahn School of Medicine at Mount Sinai, NY, USA);
Discovery of Chemical Probes for Histone Methyltransferases
2:30 - 2:55 Dr. Robert Campbell (Eli Lilly, IN, USA)
A proteomics approach to the identification of novel SMYD2 substrates
3:00 - 3:30 Coffee Break (Provided by Cayman Chemical)
Chairperson: Dr. Masoud Vedadi
3:30 - 3:55 Dr. Mark Bedford (University of Texas, USA);
New CARM1 substrates and PRMT5 interactions
4:00 - 4:25 Dr. Taiping Chen (University of Texas, USA);
Identification and characterization of nonhistone substrates of KMTs and KDMs
4:30 - 4:55 Dr. Ho Man Chan (Novartis, Massachusetts , USA);
Resistance mechanism to EZH2 inhibitor
August 20th 2015
DNA and RNA methyltransferases
9:00 – 9:30 Breakfast
9:30 - 10:00 Dr. Masoud Vedadi (University of Toronto)
Chemical probes for RNA and DNA methyltransferases; Assays and Screening
10.00 -10:35 Dr. Chuan He (University of Chicago, USA);
Reversible RNA methylation in gene expression regulation
10:40 - 11:15 Dr. Paola Arimondo (CNRS-Pierre Fabre, France);
Targeting DNA methylation
11:20 - 11:55 Dr. Blerta Xhemalce (University of Texas, USA);
Role of non coding RNA methylation in cancer and disease
Organizing Committee Masoud Vedadi Cheryl Arrowsmith Santha Santhakumar | Supported by The Department of Pharmacology
and Toxicology University of Toronto
|
Sponsored by ChemNet, an NSERC CREATE medicinal chemistry training programme in partnership with the SGC and the pharmaceutical industry.
