Our Science

The SGC is a public-private partnership whose mandate is to promote the development of new medicines by carrying out basic science of relevance to drug discovery and placing all information, reagents and know-how into the public domain without restriction.

The core mandate of the SGC is to determine 3D structures on a large scale and cost-effectively - targeting human proteins of biomedical importance and proteins from human parasites that represent potential drug targets. In these two areas, the SGC is now responsible for >25% and >50% of all structures deposited into the Protein Data Bank each year. Our structural biology insights have allowed us to make significant progress toward the understanding of

Signal transduction

Epigenetics and chromatin biology

Metabolic disease