SGC Unicamp Postdoctoral Research Associate

Postdoctoral Research Associate, Protein Biochemistry (2 positions)
Structural Genomics Consortium at UNICAMP, SP, Brazil

 

Job Title: Postdoctoral Research Associate
Vacancy ID: SGC-POSDOC4
Working Hours: Full time
Salary: Dependent on experience
Duration of Appointment: 2 years in the first instance with the possibility of renewal for a further year
Posting open date: 09/08/2017
Posting closing date: 30/09/2017

About the Structural Genomics Consortium:

The Structural Genomics Consortium (SGC) is a not-for-profit open science partnership that funds pre-competitive research. The aim is to contribute to new hypotheses in understanding and treating human disease, and the subsequent identification of new targets for drug discovery. The SGC supports pioneering research at the University of Oxford (UK), University of Toronto (Canada), State University of Campinas (Brazil), and University of North Carolina (USA). The reagents and knowledge related to proteins that the SGC supports are made openly accessible to researchers around the world to accelerate the discovery of new medicines in order to bring potentially life-saving drugs to market faster and at a lower cost.
SGC-UNICAMP, a part of the State University of Campinas (UNICAMP) receives funding from public and private sector organisations, including FAPESP, CNPq, Embrapii and the SGC. Research in SGC-UNICAMP is focused on the discovery of selective chemical probes that can modulate protein function, and the development of sets of reagents that enable research on novel targets (target enabling packages). Particular areas of interest are human protein kinases and plant protein kinases involved in desirable traits such as drought-resistance. SGC Campinas shares its research outputs through collaborations with researchers worldwide.
The SGC-UNICAMP lab is two years old and has state-of-the-art equipment and facilities for cell culture, recombinant protein production, protein crystallization, small molecule screening and medicinal chemistry. SGC-UNICAMP has easy access to genomics and proteomics facilities, and access to synchrotron beamlines locally and abroad.

About the available positions:

Up to two postdoctoral positions for Protein Biochemists are available at the Structural Genomics Consortium (SGC) at the State University of Campinas (UNICAMP), Campinas, Brazil. We are building a team with a range of skills and are looking for talented scientists who can complement our team.
We are looking for highly motivated scientists with a medicinal chemistry background who are interesting in using their skills to understand human health. The project develops chemical tools to study the cellular function of proteins and their role in normal and diseased cells.
You will gain in-depth experience in leading projects, in inhibitor design, and especially in chemical probe development. You will keep records in an electronic laboratory notebook, present your results at scientific conferences, and write and publish scientific papers in high quality, peer-reviewed journals.

The project

We are developing chemical probes for protein kinases, these are potent and very specific inhibitors of a protein kinase that can be used to understand the function of the protein in cells. For example, inhibitors must have IC50 < 50 nM, and only inhibit the desired kinase target or at most one or two others. The inhibitors must work in cellular assays and not be overly toxic to cells.
We have several active projects on different protein kinases and chemical starting points for many more.
In the future it is likely there would be opportunities to work on inhibitor development for other types of protein, for example proteins from human parasites (e.g. Leishmania) that are of interest as potential drug targets.

Responsibilities:

  • Design and synthesise new inhibitors, including information from co-crystal structures and inhibition assays in the design of the inhibitors.
  • Design synthetic routes for the synthesis of the inhibitors.
  • Manage your projects, conceiving and designing the experiments.
  • Contribute to the scientific output of the SGC by publishing high quality manuscripts and by representing the group at scientific meetings.
  • Help with the supervision of students and trainees.
  • Writing progress reports and effectively communicate project information to other members of the team.
  • Perform any other relevant duties as may reasonably be associated with the post.

 

Essential requirements:

  • PhD in Chemistry, majoring in synthetic organic chemistry.
  • Experience of medicinal chemistry methodologies.
  • Excellent oral presentation and written communication skills including evidence of independently writing scientific manuscripts.
  • Good spoken and written English.

Desirable requirements:

  • Experience of protein inhibitor development in an academic or pharma environment.
  • Experience of running simple assays of inhibitors with proteins.

Equal Opportunity Employer:

The University of Campinas, UNICAMP is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender, gender expression, gender identity, genetic information, race, national origin, religion, sex, sexual orientation, or status Special Physical and Mental Requirements: Must comply with all environmental health and safety rules including proper use of personal protective equipment.

How to apply:

Please send, in English, a CV and a letter describing your motivations for applying.
Please include the name and contact information (including email) of two references.
Applications should be sent to sgc-unicamp-jobs[at]thesgc.org

Contact Details: 
sgc-unicamp-jobs@thesgc.org
Closing Date: 
Saturday 30th September 2017
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