SGC-UNICAMP Protein Biochemistry Postdoctoral Research Associate

Postdoctoral Research Associate, Protein Biochemistry (3 positions)

Structural Genomics Consortium at UNICAMP, SP, Brazil

 

Job Title: Postdoctoral Research Associate
Vacancy ID: SGC-POSDOC1
Working Hours: Full time
Salary: Dependent on experience
Duration of Appointment: 2 years in the first instance with the possibility of renewal for a further year
Posting open date: 12/05/2017
Posting closing date: 12/07/2017
The positions will be open until filled.

About the Structural Genomics Consortium:

The Structural Genomics Consortium (SGC) is a not-for-profit open science partnership that funds pre-competitive research. The aim is to contribute to new hypotheses in understanding and treating human disease, and the subsequent identification of new targets for drug discovery. The SGC supports pioneering research at the University of Oxford (UK), University of Toronto (Canada), State University of Campinas (Brazil), and University of North Carolina (USA). The reagents and knowledge related to proteins that the SGC supports are made openly accessible to researchers around the world to accelerate the discovery of new medicines in order to bring potentially life-saving drugs to market faster and at a lower cost.
SGC-UNICAMP, a part of the State University of Campinas (UNICAMP) receives funding from public and private sector organisations, including FAPESP, CNPq, Embrapii and the SGC. Research in SGC-UNICAMP is focused on the discovery of selective chemical probes that can modulate protein function, and the development of sets of reagents that enable research on novel targets (target enabling packages). Particular areas of interest are human protein kinases and plant protein kinases involved in desirable traits such as drought-resistance. SGC Campinas shares its research outputs through collaborations with researchers worldwide.
The SGC-UNICAMP lab is two years old and has state-of-the-art equipment and facilities for cell culture, recombinant protein production, protein crystallization, small molecule screening and medicinal chemistry. SGC-UNICAMP has easy access to genomics and proteomics facilities, and access to synchrotron beamlines locally and abroad.

About the available positions:

Up to three postdoctoral positions for Protein Biochemists are available at the Structural Genomics Consortium (SGC) at the State University of Campinas (UNICAMP), Campinas, Brazil. We are building a team with a range of skills and are looking for talented scientists who can complement our team.
We are looking for highly motivated scientists with a strong interest in using chemical biology to understand human health. The project develops chemical tools to study the cellular function of proteins and their role in normal and diseased cells.
You will gain in-depth experience on leading projects, in construct design, biochemical assays, recombinant protein production, structural biology, and especially in chemical probe development. You will keep records in an electronic laboratory notebook, present your results at scientific conferences, and write and publish scientific papers in high quality, peer-reviewed journals.

The projects
There are various projects available, including:

  • Protein kinases involved in regulating repair of DNA damage (e.g. NEK kinases)
  • Protein kinases involved in regulating DNA splicing (SPRKs, DYRKs)
  • Targeting specific bacterial proteins to develop new anti-infective treatments

Responsibilities:

  • Establish efficient expression and purification systems of proteins of interest.
  • Develop biochemical and biophysical assays and study the interaction of small molecule inhibitors with proteins.
  • Co-crystallization of inhibitors with target proteins.
  • Manage your projects, conceiving and designing the experiments.
  • Contribute to the scientific output of the SGC by publishing high quality manuscripts and by representing the group at scientific meetings.
  • Help with the supervision of students and trainees.
  • Writing progress reports and effectively communicating project information to other members of the team.
  • Perform any other relevant duties as may reasonably be associated with the post.

Essential requirements:

  • PhD in Biochemistry, Chemistry, Molecular Biology, Structural Biology or related disciplines.
  • Experience of recombinant protein production.
  • Additional experience in at least one of the following areas: molecular biology, enzyme assays, cellular assays or protein crystallography.
  • Strong organizational and interpersonal skills.
  • Ability to work as part of a team.
  • Excellent oral presentation and written communication skills including evidence of independently writing scientific manuscripts.
  • Good spoken and written English.

Desirable requirements:

  • Experience of inhibitor development in an academic or pharma environment.
  • Experience of protein expression methods using prokaryotic or eukaryotic systems, in particular insect cell expression systems.
  • Experience of protein crystallography.

Equal Opportunity Employer:

The University of Campinas, UNICAMP is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender, gender expression, gender identity, genetic information, race, national origin, religion, sex, sexual orientation, or status Special Physical and Mental Requirements: Must comply with all environmental health and safety rules including proper use of personal protective equipment.

How to apply:
Please send, in English, a CV and a letter describing your motivations for applying.
Please include the name and contact information (including email) of two references.
Applications should be sent to sgc-unicamp-jobs[at]thesgc.org

Informal enquiries about the positions may be sent to jon.elkins[at]sgc.ox.ac.uk

Contact Details: 
sgc-unicamp-jobs@thesgc.org
Closing Date: 
Wednesday 12th July 2017
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