|Position Title||Postdoctoral Research Associate|
|Department||SOP-Catalyst Project - 450104|
|Position Type||Postdoctoral Scholar|
|Salary Range||Dependent on Experience|
|If part-time, hours per week|
|Proposed Start Date||03/01/2017|
|Estimated Duration of Appointment||24 Months|
|Posting Open Date||01/26/2017|
|Posting Close Date||08/01/2017|
|Open Until Filled||Yes|
|Work Location||Chapel Hill, NC|
The UNC Eshelman School of Pharmacy is seeking two candidates for a two-year postdoctoral research fellowship to evaluate the functional consequences of genetic variants linked with rare diseases.
The UNC Catalyst for Rare Diseases (‘the Catalyst’) within the UNC Eshelman School of Pharmacy is a newly established research group funded by the Eshelman Institute for Innovation and is committed to seeking greater scientific understanding of diseases caused by genetic mutations. The mission of the UNC Catalyst, working in partnership with the Structural Genomics Consortium and Genetic Alliance, will be to establish itself as a critical resource for patient organizations that lack ‘wet lab’ capabilities to pursue rare disease research objectives.
A postdoctoral position is available immediately for a highly motivated scientist interested in characterizing the molecular, biochemical and cellular impact of gene mutations.
Recent advances in molecular biology have made it possible to evaluate the biological impact of specific gene mutations through the use of targeted gene editing methodologies. However, our ability to explore the underlying pathology linked with specific rare disease gene mutations is limited by the availability of the appropriate research tools. The bulk of the work undertaken by the postdoctoral fellow will focus on creating molecular and cellular tools to explore the impact of the mutations on biological pathways. A specific aim will be to create isogenic cell lines that harbor either a functional or a non-functional version of a target protein in order to enable a more comprehensive analysis of target function. These biological reagents will be used by the postdoctoral fellow and also made available to the external research community in an unrestricted manner. Ultimately, it is envisioned that these tools and the research studies they enable will lead to the definition of options for therapeutic intervention.
This is a tremendous opportunity to join an interdisciplinary collaborative team that is committed to improving the health and well-being of rare disease patients. In addition to driving at the science at the bench, the fellow will interact directly with patients and patient group or foundation representatives, thereby providing a ‘human face’ to the research work. Ultimately, it is expected that the fellow will become recognized as a key source of knowledge and tools for that rare disease and be able to initiate and drive independent research programs.
PhD in a relevant field of study and a publication record demonstrating research productivity
|Qualifications and Experience||
The project will involve a significant amount of molecular and cell biology lab work. Experience with gene manipulation using the latest editing technologies is highly desirable. Additionally, experience with functional genomics, bioinformatics, and next-generation sequencing is highly desirable.
Excellent communication, organization, writing and data analysis skills are also essential as well as a positive outlook and team-oriented attitude.
|Equal Opportunity Employer||
The University of North Carolina at Chapel Hill is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender, gender expression, gender identity, genetic information, race, national origin, religion, sex, sexual orientation, or status as a protected veteran.
For information on UNC Postdoctoral Benefits and Services click here
|Special Physical and Mental Requirements|
|Department Contact Name and Title||K.D. Ann Welsh, HR Specialist|
|Department Contact Telephone or Email||kwelsh[at]unc.edu|
|Postdoctoral Affairs Contact Information||
If you experience any problems accessing the system or have questions about the application process, please contact the University’s Equal Employment Opportunity office at (919)-962-1091 or send an email to equalopportunity[at]unc.edu.
Please note: The Equal Employment Opportunity office will not be able to provide specific updates regarding position or application status.