Description: The Tong lab at the Structural Genomics Consortium (SGC) of the University of Toronto is seeking a talented and self-motivated PhD scientist to study the structure, function and mechanism of deubiquitinases (DUBs), with a focus on the role of DUBs in stress response and gene regulation. The successful candidate will utilize the high-throughput structural biology (HTSB) platform and biochemical/biophysical techniques to study the activity and regulatory mechanisms of these enzymes. S/he is expected to make primary contributions to publications in high quality peer-reviewed journals. This position is available immediately. The Tong lab has institutional support from the SGC and grant support from NSERC and the Janssen Neuroscience Catalyst.
List of publications is available at http://scholar.google.ca/citations?user=xVRq4IEAAAAJ&sortby=pubdate
Qualifications: The ideal candidate will have a strong background in biochemistry with practical experience in protein purification and good written and verbal English skills along with a strong work ethic and enthusiasm for scientific research. 0-2 years postdoctoral experience is preferred. Experience in protein purification using FPLC system is a must; experience in enzymology, X-ray crystallography or cryo-EM considered an asset.
Contact: Interested individuals: please send a current CV (including contact info of three referees) and a cover letter stating your research interests and career plan to Dr. Yufeng Tong at yufeng.tong[at]utoronto.ca with the term “ubiquitin position” in the subject line. Position posted until filled.
About the SGC: SGC is a research organization focusing on the protein science and chemical biology of disease-related proteins especially those in epigenetic pathways. SGC is jointly funded by pharma companies and public funding agencies. The HTSB platform at SGC provides access to high capacity prokaryotic and eukaryotic expression systems and state-of-the-art protein purification and crystallography facilities, and is supported by core service groups including biotech, crystallography and biophysics. Access to single particle cryo-microscopy is available through a service facility at the University and the SGC collaboration network. More information is available online at http://www.thesgc.org/
For more information on the Tong lab: http://www.thesgc.org/profile/toronto/ytong
About Toronto: SGC provides a stimulating and friendly working environment in the heart of the University of Toronto and its affiliated hospital research institutes. Together these institutions comprise one of the largest and most productive centers of biomedical research in North America. The city of Toronto is a safe, dynamic and multi-cultural metropolis, located in the center of the second largest bio-cluster in North American (the Québec-Ontario Life Sciences Cluster) and ranked fourth in the World’s Most Liveable Cities in 2016 by The Economist Intelligence Unit.