ChemNET’s 2015 bootcamp from August 10th – August 20th.
Courses and workshops
An Introduction to Project management (by Procept Associates ltd)
Structure based drug design and Molecular modelling (by Prof. Nicolas Moitessier, McGill University)
This workshop aims to provide an opportunity for participants to learn how to implement differential scanning fluorimetry (DSF), radioactivity-based activity assays and peptide displacement methods.
Understanding concepts in crystallography is important, but for Structure-Based Drug Discovery, it is more important to have a good idea of where structures come from, how they are solved, and most important to have the ability to assess model quality. SBDD requires analysis of positioning of each atom in the active site and each atom of a potential drug or ligand. Therefore understanding how to interpret models and how far to trust crystallographic data will be emphasized over theory in this class.
Protein Production & Purification - Access to high-quality protein is a prerequisite for crystallography, assay development and biophysical characterization. A major part of the resources at SGC is therefore spent in this area and we produce proteins, both through general high-throughput methods and one by one in complicated tailor-made processes. At the ChemNET boot camp we will run a workshop on protein production using the general high-throughput method to purify a set of ~12 proteins in parallel. The participants will get hands-on experience in using the LEX system for E.coli growth and the ÄKTA Xpress for parallel purification. We will also theoretically go over the cloning and expression screening methods and the eukaryotic expression systems used at the SGC.
ChemNET Trainees participating in bootcamp 2015
|Matt Alteen||Simon Fraser University||Dr. David Vocadlo|
|Venugopal Rao Challa||Simon Fraser University||Dr. B. Mario Pinto|
|Damien Bosc||Simon Fraser University||Dr. Robert Young|
|Juan Salinas Hernandez||Université de Montréal||Dr. Steve Hanessian|
|Ben Loosely||University of British Columbia||Dr. Raymond Andersen|
|Yasaman Mahdavi-Amiri||Simon Fraser University||Dr. B. Mario Pinto|
|Zafar Qureshi||University of Toronto||Dr Mark Lautens|
|Yun Shi||Simon Fraser University||Dr. B. Mario Pinto|
|Dostie Starr||IRCM – Institut de Recherches Clinique de Montréal||Dr. Yvan Guindon|