2nd Oxford Symposium on Epigenetic Mechanisms in Health and Disease

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2nd Oxford Symposium on Epigenetic Mechanisms in Health and Disease

Role of Chromatin Modifications in Inflammation. Oxford December 9-10,2010, Said Business School

Chromatin biology and epigenetics is a fast growing field at the frontier of modern biology, with considerable impact on fundamental mechanisms of health and disease.
This 2nd Oxford symposium aims to bring together clinical and preclinical scientists engaged at the forefront of control of inflammation and cancer through epigenetic and chromatin mechanisms.
We aim to explore future trends in epigenetics and related fields of gene regulation and signalling with an emphasis on prospects of translation into clinical treatments of inflammatory disorders.

Programme

Programme Details

Thursday, December 9^th Nelson Mandela Hall

Registration: 8 am start

8:45 Introduction - Udo Oppermann (SGC Oxford & NDORMS, University of Oxford)

Session 1: Chromatin modifications and inflammation (Chair: Paul Wordsworth, Oxford)

Plenary Lecture:

9:00 The macrophage epigenome and the transcriptional control of innate immunity and inflammation - Gioacchino Natoli (European Institute of Oncology, Milan)

10:00- 10:30 Coffee Break

10:30 Chromatin modifying enzymes: their function and role in cancer - Tony Kouzarides (Cambridge, UK)

11:00 Lysine Methylation Signaling in Inflammation - Or Gozani (Stanford, USA)

11:30 Diabetic complications as a result of prior poor glycemic control mediated by persistent gene activating epigenetic changes - Assam El-Osta (Baker Medical Research Institute, Australia)

12:00 HMGB1 Controls The Number Of Nucleosomes - Marco Bianchi (Fondazione San Raffaele del Monte Tabo, Milan)

12:30 An epigenetic switch that links inflammation and Polycomb complexes to cancer - Kevin Struhl (Harvard, USA)

13:00-14:00 Lunch Break

Session 2: Epigenetic control of Inflammation (Chair: Fionula Brennan, Imperial College)

14:00 Epigenetics and airway inflammation - Ian Adcock (Imperial College, London)

14:30 Writers, Readers, and Erasers: Dynamic chromatin remodelling events dictate the immune cell phenotype - Steven Kunkel (Michigan, USA)

15:00-15:30 Coffee Break

15:30 Silencing inflammatory genes in T lymphocyte immunity and tolerance - Andrew Wells (Abramson Research Center/Children's Hospital of Philadelphia, USA)

16:00 Methylation matters: epigenetic control of Foxp3 expression in stable regulatory T cells - Jochen Huehn (Helmholtz Gesellschaft, Germany)

16:30 Epigenetics in Autoimmunity - Steffen Gay (Zurich, Switzerland)

Friday, December 10^th Nelson Mandela Hall

Session 3: From Biology to Medicine: targeting the reader domains (Chair: Chris Schofield, Oxford)

Plenary Lecture:

9:00 Histone Mimicry - Alexander Tarakhovsky (Rockefeller, USA)

10:00 Discovery of potent and selective small molecule inhibitors of the BET family bromodomains demonstrate the tractability of this reader class for drug discovery - Chun-wa Chung (GSK)

10:30-11:15 Coffee Break

11:15 Targeting Bromo domains for selective ligand design Stefan Knapp (Oxford, UK)

12:00- 13:30 Lunch Break

Session 4: Epigenetic Target discovery in cancer and inflammation (Chair: Rab Prinjha, GSK-EpiNova, Stevenage, UK)

13:30 Control of tumour suppressor protein activity: interplay between epigenetic marks in the regulation of p53 and pRb - Nick LaThangue (Oxford, UK)

14:00 The Protein Arginine Deiminases: Therapeutic targets for Rheumatoid Arthritis, Colitis, and Cancer - Paul Thompson (Scripps Research Institute, USA)

14:30- 15:00 Coffee Break

15:00 Novel Small molecule Inhibitors of KMT7, A Lysine Mono-Methyltransferase - Caroline Benn (Pfizer, UK)

15:30 HDAC and LSD Inhibitors: Cancer and Beyond - Ganesan (Southampton, UK)

16:00 Concluding remarks - Chas Bountra (SGC Oxford)

Speakers

Scientific Committee

Chas Bountra (SGC, Oxford, UK)
Roy Katso (GSK, Stevenage, UK)
David Wilson (GSK, Stevenage, UK)
Rabinder Prinjha (GSK, Stevenage, UK)
Caroline Benn (Pfizer, Sandwich, UK)
Paul Fish (Pfizer, Sandwich, UK)
Iain Kilty (Pfizer, Sandwich, UK)
Karl Nocka (Pfizer, Cambridge, Mass., USA)
Tom Heightman (SGC, Oxford, UK)
Cheryl Arrowsmith (SGC, Toronto, Canada)
Rob Klose(Biochemistry, Oxford, UK)
Chris Schofield (Chemistry, Oxford, UK)
Guenther Eissner (Munich, Germany)
Udo Oppermann (SGC, Oxford)

Organisers

Organising Committee

Udo Oppermann (SGC/NDORMS, Oxford)
Brian Marsden (SGC, Oxford)
Wen Hwa Lee (SGC, Oxford)
Hong Harper (SGC, Oxford)
Joanna Zapisek (SGC, Oxford)
Melissa Matthews (SGC, Oxford)
Magdalena Kalinowska (SGC, Oxford)
Mio Murphy-Shaw (NDORMS, Oxford)

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2nd Oxford Symposium on Epigenetic Mechanisms in Health and Disease

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