Frontiers in Integral Membrane Protein Structural Biology

Frontiers in Integral Membrane Protein Structural Biology

Dates: 5th - 7th October, 2015
Venue: Mathematical Institute, Oxford UK

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The Symposium

Structural biology of membrane proteins, particularly from higher eukaryotes, has been transformed in the last two years. New and improved technologies such as electron microscopy and free electron lasers have led to the rapid increase in the number of structures solved and the complexity of these structures. This symposium will highlight advances in technology, celebrate the unprecedented advances in understanding of membrane protein structure and function, and look to the future for this rapidly developing field.

Organizer: Liz Carpenter, SGC, University of Oxford

The event is sold out and the waiting list has now closed.

Confirmed speakers

Radu Aricescu, STRUBI, Oxford
Imre Berger, Bristol University, UK
Nicola Burgess-Brown, SGC, UK
Liz Carpenter, SGC, UK
Vadim Cherezov, UCS, USA
Katharina Dürr, Vollum Institute, USA
Raimund Dutzler, Zurich, Switzerland
Petra Fromme, ASU USA
Adrian Goldman, Leeds, UK
Bert de Groot, Göttingen, Germany
Christopher Koth, Genentech, USA
Werner Kühlbrandt, Frankfurt, Germany
Kaspar Locher, ETH Zurich, Switzerland
James Love, New York, USA
Thomas Meier, Imperial College, London
Jim Naismith, St. Andrews, UK

Simon Newstead, Biochemistry, Oxford
Poul Nissen, Aarhus, Denmark
Bjørn Pedersen, Aarhus, Denmark
Eduardo Perozo, Chicago, USA
Carol Robinson, Chemistry, Oxford
Mark Sansom, Biochemistry, Oxford
Sjors Scheres, Cambridge, UK
Gebhard Schertler, PSI, Switzerland
Ray Stevens, USC, USA
Bob Stroud, USC, USA
Robert Tampé, Frankfurt , Germany
Chris Tate, Cambridge, UK
Stephen Tucker, Physics, Oxford
K. Vinothkumar, LMB, Cambridge, UK
Bonnie Wallace, Birkbeck College, UK
Christine Ziegler, Regensburg, Germany

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Programme

Programme (download pdf version)

Day 1, 5th October

Day 2, 6th October

Day 3, 7th October

Day 1 , 5th October 2015

8:45 - 9:20	Registration and coffee
9:20 – 9:30	Welcome Liz Carpenter, SGC, Oxford, UK Membrane Protein Expression/Purification Chair: Liz Carpenter, SGC, Oxford, UK
09:30 – 10:00	James Love, Einstein, NY, USA "Production of Human Membrane Proteins for Structural and Functional Studies"
10:00 – 10:30	Nicola Burgess-Brown, SGC, Oxford, UK "Expressing Human Integral Membrane Proteins"
10:30– 11:00	Imre Berger, Bristol, UK "ACEMBLing a Multiprotein Transmembrane Complex: The Functional SecYEG-DecDF-YajC-YidC Holotranslocon Protein Secretase/Insertase"
11:00 – 11:30	Coffee Chair: Vadim Cherezov, USC, USA
11:30 – 12:00	Chris Tate, Cambridge, UK "Optimising functional expression of membrane proteins in mammalian cells"
	Free electron laser crystallography
12:00 – 12:30	Petra Fromme, Arizona State, USA "Femtosecond Crystallography opens a new era in Membrane Protein Structural Biology"
12:30 – 13:00	Jim Naismith, St. Andrews, UK "SFX @ EU XFEL and MscS"
13:00 – 14:00	Lunch and Posters
	Electron Microscopy Chair: Juha Huiskonen, OPIC, WTCHG, Oxford
14.00 - 14.30	Sjors Scheres, LMB, Cambridge, UK "How cryo-EM is revolutionizing structural biology"
14.30 - 15.00	K. Vinothkumar, LMB, Cambridge, UK "Arrangement of supernumerary subunits in mammalian mitochondrial complex I"
15.00 - 15.30	Werner Kühlbrandt, Frankfurt, Germany "High-resolution electron cryo-microscopy of membrane protein complexes"
15.30 - 16.00	Tea
	Simulations and ion channel function Chair: Jim Naismith, St Andrews, UK
16.00 - 16.30	Mark Sansom, Biochemistry, Oxford, UK "Membrane Proteins in Membranes: Using Simulations to Transplant Structures Back to their Cellular Environment"
16.30 - 17.00	Bert de Groot, Goettingen, Germany "The molecular dynamics of channel permeation, inhibition and gating"
17.00 - 17.30	Stephen Tucker, Physics, Oxford, UK "Functional validation of a model for hydrophobic gating in a K+ channel"
	Talks selected from poster abstracts Chair: Nicola Burgess-Brown, SGC, Oxford, UK
17.30 – 17.45	Juni Andréll, LMB, Cambridge, UK "Using flow cytometry to optimise overproduction of integral membrane proteins in inducible mammalian cell lines"
17.45 – 18.00	Veronika Heinz, Regensburg, Germany "Structural characterization of stressosome complexes by Single-particle cryo-electron microscopy"
18.00 – 18.15	Pikyee Ma, Trinity College Dublin, Republic of Ireland "The Cubicon Method for Concentrating Membrane Proteins in the Cubic Mesophase"
18.15 – 18.30	Dirk Slotboom, Groningen, Netherlands "The structural basis of toppling in ECF-type ABC transporters"

Day 2 , 6th October 2015

	Ion Channels Chair: Bonnie Wallace, Birkbeck College, London
9.00 – 9.30	Raimund Dutzler, Zurich, Switzerland "The structure and function of calcium activated TMEM16 channels and scramblases"
09.30 – 10.00	Liz Carpenter, SGC, Oxford, UK "From the SGC pipeline to an understanding of TREK channel mechanosensitivity and inhibition"
10.00 – 10.30	Radu Aricescu, STRUBI, Oxford, UK "Crystal structure of a human GABAA receptor"
10.30– 11.00	Katharina Dürr, Vollum Institute, Oregon, USA "Structural insights into activation and desensitization of AMPA receptors"
11.00 – 11.30	Coffee
	Ion Channels Chair: Poul Nissen, Aarhus, Denmark
11.30 – 12.00	Bonnie Wallace, Birkbeck, London, UK "Sodium Channels: Structure, Function, Ion Selectivity, and Drug Binding"
12.00 – 12.30	Christopher Koth, Genentech, USA "Engineering Membrane Proteins for Structure and Drug Discovery: The Painful Route to Painless Views of Nav1.7"
12.30 – 13.00	Eduardo Perozo, Chicago, USA "Asymmetric Conformational Transition Underlies Mg2+-Driven Gating in CorA"
13.00 – 14.00	Lunch
	Solute carriers Chair: Eduardo Perozo, Chicago, USA
14.00 - 14.30	Bob Stroud, UCSF, USA "What can we learn from the structures of membrane secondary transporters?"
14.30 - 15.00	Simon Newstead, Biochemistry, Oxford, UK "Crystal structures of a dual-topology, double-barrelled fluoride ion channel"
15.00 - 15.30	Bjørn Pedersen, Aarhus, Denmark "Example of Symport in the Major Facilitator Superfamily from a Structural Perspective"
15.30 - 16.00	Christine Ziegler, Regensburg, Germany "Transport regulation mechanism in BetP"
16.00 - 16.30	Tea
	GPCRs Chair: Bob Stroud, UCSF, USA
16.30 - 17.00	Ray Stevens , USC, USA "Structural Coverage of the Complete GPCR Superfamily"
17.00 - 17.30	Gebhard Schertler, PSI, Switzerland "The impact of Free Electron Lasers on membrane protein structural biology"
17.30 - 18.00	Vadim Cherezov, USC, USA "Serial Crystallography of GPCRs"
	Talks selected from poster abstracts Chair: Ray Stevens, USC, USA
18.00 – 18.15	Phil Stansfeld, Biochemistry, Oxford, UK "MemProtMD: Restoring Membrane Protein Structures to Lipid Bilayers"
18.15 – 18.30	Chitra Shintre, SGC, Oxford, UK "Structural studies of a human ABC transporter, ABCB10, reveal an occluded conformation, as well as open-inwards states."
18.30 – 18.45	Patricia Dijkman, Biochemistry, Oxford, UK "Dynamic GPCR dimerisation probed by ensemble and single-molecule FRET, DEER, and simulations"
18.45 – 19.00	Andreas Blees, Frankfurt. Germany "Function and Structure of the MHC I Peptide-Loading Complex"

Day 3 , 7th October 2015

	Pumps and ATPases Chair: Christine Ziegler, Regensburg, Germany
9.00 – 9.30	Poul Nissen, Aarhus, Denmark "P-type ATPases on the move – structure, mechanism and dynamics"
9.30 – 10.00	Thomas Meier, Imperial, London, UK "Structure of complete rotary ATP synthase and its role as new drug target against tuberculosis"
10.00 – 10.30	Adrian Goldman, Leeds, UK "From pyrophosphate-primed proton pumps"
10.30– 11.00	Coffee
	ABC transporters Chair: Fran Ashcroft, DPAG, Oxford, UK
11.00 – 11.30	Kaspar Locher, ETH Zurich, Switzerland "Structure and mechanism of an ATP-driven flippase of lipid-linked oligosaccharides"
11.30 – 12.00	Robert Tampé, Frankfurt, Germany "New insights into heterodimeric ABC transporters via integrative structural biology"
12.00 – 12.30	Carol Robinson, Chemistry, Oxford, UK "Mass spectrometry of membrane proteins - the lipid connection"
12.30 – 12.45	Poster prizes and wrap up session
12.50	End of meeting

Delegates

Confirmed speakers

Radu Aricescu, STRUBI, Oxford
Imre Berger, Bristol University, UK
Nicola Burgess-Brown, SGC, UK
Liz Carpenter, SGC, UK
Vadim Cherezov, UCS, USA
Katharina Dürr, Vollum Institute, USA
Raimund Dutzler, Zurich, Switzerland
Petra Fromme, ASU USA
Adrian Goldman, Leeds, UK
Bert de Groot, Goettingen, Germany
Christopher Koth, Genentech, USA
Werner Kühlbrandt, Frankfurt, Germany
Kaspar Locher, ETH Zurich, Switzerland
James Love, New York, USA
Thomas Meier, Imperial College, London
Jim Naismith, St Andrews, UK

Simon Newstead, Biochemistry, Oxford
Poul Nissen, Aarhus, Denmark
Bjørn Pedersen, Aarhus, Denmark
Eduardo Perozo, Chicago, USA
Carol Robinson, Chemistry, Oxford
Mark Sansom, Biochemistry, Oxford
Sjors Scheres, Cambridge, UK
Gebhard Schertler, PSI, Switzerland
Ray Stevens, USC, USA
Bob Stroud, USC, USA
Robert Tampé, Frankfurt , Germany
Chris Tate, Cambridge, UK
Stephen Tucker, Physics, Oxford
K. Vinothkumar, LMB, Cambridge, UK
Bonnie Wallace, Birkbeck College, UK
Christine Ziegler, Regensburg, Germany

Abstracts

Registration is now closed.

Registration

Registration

Sorry, registration is closed.

Registration fees*

Academic delegates: £100

Industry delegates: £250

*Please note that registration provides access the meeting and lunch on the 5^th and 6^th of October. It does not cover travel and accommodation.

Delegates will need to arrange and pay for their travel, accommodation and subsistence.

Posters

Posters

Registration is now closed.

Posters will be displayed during the meeting and a series of 10 min talks will be selected from the poster abstracts.

Please provide a title and a 150 word abstract when you register.

We will also provide up to 10 student bursaries based on poster abstracts, which will cover the registration fee (but not travel and accommodation).

There will be poster prizes at the end of the meeting.

Venue

Venue

Mathematical Institute
University of Oxford
Andrew Wiles Building
Radcliffe Observatory Quarter
Woodstock Road
Oxford
OX2 6GG
web site

Accommodation

Accommodation in Oxford

Oxford is well served by a large range of hotels and guest houses, many within walking distance of the symposium venue. We would like to recommend that you book your accommodation as soon as possible, as Oxford is a very popular destination.

Below is a list of links to help you to find your accommodation:

•Late Rooms

•Visit Oxfordshire

•LastMinute.com

•Booking.com