September 6 [9:00 am – 6:00 pm CEST] |
Welcome & introduction |
Opher Gileadi |
9:00-9:10 am |
Team Leader, SGC Karolinska |
Session 1 |
SGC – the first 20 years
Chaired by Opher Gileadi, SGC Karolinska |
9:10-9:25 am
15 min |
Why create the SGC? |
Robert Cooke,
SGC Alumnus |
9:25-9:50 am
25 min |
Targeting kinase scaffolding versus kinase catalytic function |
Stefan Knapp,
SGC Frankfurt |
9:50-10:10 am
20 min |
From Discovery to Clinical Trials – applications, pitfalls, and
achievements of chemical tools for epigenetic research |
Udo Oppermann,
University of Oxford |
10:10-10:30
20 min |
Structure and function of human membrane proteins associated with genetic diseases
|
Liz Carpenter,
SGC Alumnus |
10:30 - 10:50 am |
Coffee Break |
Session 2 |
Routes to Target 2035
Chaired by Anke Mueller Fahrnow, Chair of the SGC Board |
10:50-11:00 am
10 min |
Introduction to Target 2035 |
Anke Muller Fahrnow,
Chair of the SGC Board |
11:00-11:25
25 min |
Revisiting the promise and perils of
chemical probes: the impact of SGC and
the Chemical Probes Portal |
Paul Workman,
The Institute of Cancer Research, London
|
11:25-11:45 pm
20 min |
EUbOPEN - The first step toward Target 2035 |
Florian Montel and Oliver Krämer,
Boehringer Ingelheim
|
11:45-12:05 pm
20 min |
Probing the ubiquitin proteosome system
(UPS) for targeted protein degradation
and beyond
|
Cheryl Arrowsmith,
SGC-Toronto |
12:05-12:20 pm
15 min |
I've Got the Bio, You've Got the Chem, Let's Make Lots of Probes
|
Matthew Todd,
SGC-UCL |
12:20 - 1:20 pm |
Lunch Break |
Session 3 |
Target areas & technologies
Chaired by Susanne Mueller Knapp, SGC-Frankfurt |
1:20-1:30 pm
10 min |
Introduction to Target areas & Technologies |
Susanne Mueller Knapp,
SGC-Frankfurt |
1:30-1:50 pm
20 min |
How do we express all human proteins? |
Nicola Burgess Brown,
Exact Sciences |
1:50-2:05 pm
15 min |
From decoding to reprogramming target networks
|
Matthias Gstaiger,
ETHZ |
2:05-2:20 pm
15 min |
XChem and TEPs: SGC tools enabling antiviral drug discovery
|
Lizbé Koekemoer,
Diamond Light Source |
2:20-2:30 pm
10 min |
Live cell systems for degrader
evaluation
|
Martin Schwalm,
SGC-Frankfurt |
2:30-2:40 pm
10 min |
Chemical Tools for Modulation of
Na/H Transporters
|
Jesper Hansen,
University of Oxford |
2:40-2:55 pm
15 min |
From affinity reagents to biological
probes
|
Susanne Gräslund,
Affibody |
2:55 - 3:30 pm |
Coffee Break |
Session 4 |
Translational Disease Models
Chaired by Michael Sundström, SGC-Karolinska |
3:30-3:50 pm
20 min |
Looking back - the SGC in 2043 |
Aled Edwards,
SGC CEO |
3:50-4:00 pm
10 min |
Introduction to Translational Disease Models |
Michael Sundström,
SGC-Karolinska |
4:00-4:20 pm
20 min |
Chemogenomic screening in patient-derived 3D liver models of NASH |
Volker Lauschke,
Karolinska Institutet |
4:20-4:40 pm
20 min |
How can we utilize epigenetic marks in Multiple Sclerosis?
|
Maja Jagodic,
Karolinska Institutet |
4:40-4:50 pm
10 min |
Probing the Neomorphic roles of BTB-Kelch E3 ligases in cancer
|
Zhuoyao Chen,
University of Oxford |
4:50-5:00 pm
10 min |
Wrap up and closing remarks
|
Opher Gileadi,
SGC-Karolinska |
5:00-6:00 pm
60 min |
Meet the Speakers’ Reception - discuss science and network over snacks and drinks
|
6:30 pm |
Dinner at Sangria Tapas Bar, St Eriksgatan 108
|