SGC and Abbvie publish A-395, an open access first-in-class allosteric inhibitor of PRC2

SGC and Abbvie scientists have published a research article in Nature Chemical Biology reporting a chemical probe for embryonic ectoderm development (EED) protein. The open-access probe, A-395, binds to EED inhibiting protein-protein interaction and inactivating the Polycomb repressive complex 2 (PRC2). PRC2 is dysregulated in many cancers and is a potential target for therapy.

Earlier this month, SGC and Abbvie reported on another collaboration resulting in A-196, a first-in-class open-access inhibitor against SUV4-20.

For more information and to obtain a sample of A-395: http://www.thesgc.org/chemical-probes/A-395

For the article: http://www.nature.com/nchembio/journal/vaop/ncurrent/full/nchembio.2306....

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