Fiona McCann

Team leader

University of Oxford
+44 (0)1865 227979

Having gained a PhD in Biochemistry in 2001 from the University of Kent, Fiona joined Imperial College London as a postdoc working with Prof. Dan Davis studying the spatiotemporal localization of proteins at the human Natural Killer immune synapse to determine functional outcomes of NK cell surveillance. She then joined Dr. Richard Williams' lab at the Kennedy Institute in 2006 to study translational immunology exploiting experimental models of rheumatoid arthritis. Specifically, she was the first to identify novel immunoregulatory functions of TNFR2 expressing regulatory T cells in murine arthritis. In 2012, working with Prof. Sir Marc Feldmann, she was appointed to the role of team leader for the Novo Nordisk-KIR clinical research satellite, working on target validation and mechanism of action studies in rheumatoid arthritis. Since March 2015, she has been group leader for the Oxford Tissue Platform within the ULTRA-DD consortium (IMI funded research initiative) at the KIR in collaboration with the Structural Genomics Consortium, which aims to study epigenetic modifications in both Dupuytren's disease (with Prof. Jagdeep Nanchahal) and Spondyloarthritis patients (with Prof. Paul Bowness).
 

Research Areas

The objective of the Oxford Tissue Platform is to build robust assays from patients cells and tissue, retaining where possible the native characteristics and phenotype of intact pathology. Focussing specifically on two diverse musculoskelatal diseases, Ankylosing Spondlyitis (AS) and Dupuytren’s Disease (local hand fibrosis), we study disease mechanisms for target identification through phenotypic screening of well-annotated libraries of small molecule inhibitors and function blocking antibodies.
Other interests include investigating the role of natural killer cells in AS (joint project with Nikki Horwood, KIR) and the immunoregulatory function of TNFR2 in RA (with Richard Williams, KIR).
 

Group Members

  • Lynn Williams
  • Marisa Cabrita
  • Liye Chen
  • Takuya Sekine

Publications

Natural killer (NK) cells and gamma delta T-cells differentially modulate Th17-driven disease in ankylosing spondylitis
Wythe, SE; Griseri, T; Demetriou, P; Freidin, A; Feldmann, M; McCann, FE; Horwood, N;
Immunology. 2014 143:162-162. doi:
PMID:

Selective tumor necrosis factor receptor I blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor II in collagen-induced arthritis.
McCann, FE; Perocheau, DP; Ruspi, G; Blazek, K; Davies, ML; Feldmann, M; Dean, JL; Stoop, AA; Williams, RO;
Arthritis and Rheumatology. 2014 66:2728-2738. doi: 10.1002/art.38755
PMID: 24965881

New developments in the management of psoriasis and psoriatic arthritis: a focus on apremilast.
Palfreeman, AC; McNamee, KE; McCann, FE;
Drug Design, Development and Therapy. 2013 7:201-210. doi: 10.2147/DDDT.S32713
PMID: 23569359

Blockade of NKG2D ameliorates disease in mice with collagen-induced arthritis: a potential pathogenic role in chronic inflammatory arthritis.
Andersson, AK; Sumariwalla, PF; McCann, FE; Amjadi, P; Chang, C; McNamee, K; Tornehave, D; Haase, C; Agersø, H; Stennicke, VW; Ahern, D; Ursø, B; Trowsdale, J; Feldmann, M; Brennan, FM;
Arthritis and Rheumatism. 2011 63:2617-2629. doi:
PMID: 21618462

Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.
McCann, FE; Palfreeman, AC; Andrews, M; Perocheau, DP; Inglis, JJ; Schafer, P; Feldmann, M; Williams, RO; Brennan, FM;
Arthritis Research and Therapy. 2010 12:R107-. doi: 10.1186/ar3041
PMID: 20525198

ANTI-CD3 therapy expands the numbers of CD4+ and CD8+ Treg cells and induces sustained amelioration of collagen-induced arthritis.
Notley, CA; McCann, FE; Inglis, JJ; Williams, RO;
Arthritis and Rheumatism. 2010 62:171-178. doi: 10.1002/art.25058
PMID: 20039431

Novel approaches to the therapy of rheumatoid arthritis based on an understanding of disease mechanisms
McCann, FE; Williams, RO;
Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 2008 8:275-284. doi: 10.2174/187152208785748359
PMID:

2016

TNFR signalling and its clinical implications
Tseng, WY; Huang, YS; Lin, HH; Luo, SF; McCann, F; McNamee, K; Clanchy, F; Williams, R;
Cytokine. 2016 :-. doi: 10.1016/j.cyto.2016.08.027
PMID:

Investigating the Role of Toll-Like Receptors in Models of Arthritis.
Piccinini, AM; Williams, L; McCann, FE; Midwood, KS;
Methods in Molecular Biology. 2016 1390:351-381. doi:
PMID: 26803640

2015

IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production.
Blazek, K; Eames, HL; Weiss, M; Byrne, AJ; Perocheau, D; Pease, JE; Doyle, S; McCann, F; Williams, RO; Udalova, IA;
Journal of Experimental Medicine. 2015 212:845-853. doi:
PMID: 25941255

2014

Natural killer (NK) cells and gamma delta T-cells differentially modulate Th17-driven disease in ankylosing spondylitis
Wythe, SE; Griseri, T; Demetriou, P; Freidin, A; Feldmann, M; McCann, FE; Horwood, N;
Immunology. 2014 143:162-162. doi:
PMID:

Selective tumor necrosis factor receptor I blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor II in collagen-induced arthritis.
McCann, FE; Perocheau, DP; Ruspi, G; Blazek, K; Davies, ML; Feldmann, M; Dean, JL; Stoop, AA; Williams, RO;
Arthritis and Rheumatology. 2014 66:2728-2738. doi: 10.1002/art.38755
PMID: 24965881

OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis.
Gwyer Findlay, E; Danks, L; Madden, J; Cavanagh, MM; McNamee, K; McCann, F; Snelgrove, RJ; Shaw, S; Feldmann, M; Taylor, PC; Horwood, NJ; Hussell, T;
Proceedings of the National Academy of Sciences of USA. 2014 111:2289-2294. doi:
PMID: 24469824

TNFR2 increases the sensitivity of ligand-induced activation of the p38 MAPK and NF-κB pathways and signals TRAF2 protein degradation in macrophages.
Ruspi, G; Schmidt, EM; McCann, F; Feldmann, M; Williams, RO; Stoop, AA; Dean, JL;
Cellular Signalling. 2014 26:683-690. doi:
PMID: 24378531

2013

Nuclear Receptor 4A2 Is Differentially Expressed In Animal Models Of RA During Inflammation and Resolution
Everett, J; McCann, FE; Palfreeman, AC; Shaw, AT; Gravallese, EM; Mix, KS;
Arthritis and Rheumatism. 2013 65:S542-S542. doi:
PMID:

New developments in the management of psoriasis and psoriatic arthritis: a focus on apremilast.
Palfreeman, AC; McNamee, KE; McCann, FE;
Drug Design, Development and Therapy. 2013 7:201-210. doi: 10.2147/DDDT.S32713
PMID: 23569359

2011

Blockade of NKG2D ameliorates disease in mice with collagen-induced arthritis: a potential pathogenic role in chronic inflammatory arthritis.
Andersson, AK; Sumariwalla, PF; McCann, FE; Amjadi, P; Chang, C; McNamee, K; Tornehave, D; Haase, C; Agersø, H; Stennicke, VW; Ahern, D; Ursø, B; Trowsdale, J; Feldmann, M; Brennan, FM;
Arthritis and Rheumatism. 2011 63:2617-2629. doi:
PMID: 21618462

2010

Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.
McCann, FE; Palfreeman, AC; Andrews, M; Perocheau, DP; Inglis, JJ; Schafer, P; Feldmann, M; Williams, RO; Brennan, FM;
Arthritis Research and Therapy. 2010 12:R107-. doi: 10.1186/ar3041
PMID: 20525198

ANTI-CD3 therapy expands the numbers of CD4+ and CD8+ Treg cells and induces sustained amelioration of collagen-induced arthritis.
Notley, CA; McCann, FE; Inglis, JJ; Williams, RO;
Arthritis and Rheumatism. 2010 62:171-178. doi: 10.1002/art.25058
PMID: 20039431

2008

Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells.
Notley, CA; Inglis, JJ; Alzabin, S; McCann, FE; McNamee, KE; Williams, RO;
Journal of Experimental Medicine. 2008 205:2491-2497. doi:
PMID: 18936235

Novel approaches to the therapy of rheumatoid arthritis based on an understanding of disease mechanisms
McCann, FE; Williams, RO;
Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 2008 8:275-284. doi: 10.2174/187152208785748359
PMID:

Protocol for the induction of arthritis in C57BL/6 mice.
Inglis, JJ; Simelyte, E; McCann, FE; Criado, G; Williams, RO;
Nature Protocols. 2008 3:612-618. doi:
PMID: 18388943

2007

Membranous structures transfer cell surface proteins across NK cell immune synapses.
Williams, GS; Collinson, LM; Brzostek, J; Eissmann, P; Almeida, CR; McCann, FE; Burshtyn, D; Davis, DM;
Traffic. 2007 8:1190-1204. doi:
PMID: 17605758

Inhibitory receptor signals suppress ligation-induced recruitment of NKG2D to GM1-rich membrane domains at the human NK cell immune synapse.
Endt, J; McCann, FE; Almeida, CR; Urlaub, D; Leung, R; Pende, D; Davis, DM; Watzl, C;
Journal of Immunology. 2007 178:5606-5611. doi:
PMID: 17442943

The activating NKG2D ligand MHC class I-related chain A transfers from target cells to NK cells in a manner that allows functional consequences.
McCann, FE; Eissmann, P; Onfelt, B; Leung, R; Davis, DM;
Journal of Immunology. 2007 178:3418-3426. doi:
PMID: 17339436

2005

Identification of an intestinal heme transporter.
Shayeghi, M; Latunde-Dada, GO; Oakhill, JS; Laftah, AH; Takeuchi, K; Halliday, N; Khan, Y; Warley, A; McCann, FE; Hider, RC; Frazer, DM; Anderson, GJ; Vulpe, CD; Simpson, RJ; McKie, AT;
Cell. 2005 122:789-801. doi:
PMID: 16143108

An electronically tunable ultrafast laser source applied to fluorescence imaging and microscopy including fluorescence lifetime imaging
Dunsby, C; Lanigan, PMP; McGinty, J; De Beule, PAA; Auksorius, E; Schimpf, DN; Elson, DS; Requejo-Isidro, J; Munro, I; Galletly, N; Treanor, B; Önfelt, B; McCann, F; Davis, DM; Neil, MAA; French, PMW;
. 2005 :-. doi: 10.1109/CLEOE.2005.1568395
PMID:

An electronically tunable ultrafast laser source applied to fluorescence imaging and fluorescence lifetime imaging microscopy
Lanigan, PMP; Dunsby, C; McGinty, J; Elson, DS; Requejo-Isidro, J; Munro, I; Galletly, N; Treanor, B; Onfelt, B; McCann, F; Davis, DM; Neil, MAA; French, PMW; IEEE, ;
Optics InfoBase Conference Papers. 2005 :1366-1368. doi:
PMID:

2004

An electronically tunable ultrafast laser source applied to fluorescence imaging and fluorescence lifetime imaging microscopy
Dunsby, C; Lanigan, PMP; McGinty, J; Elson, DS; Requejo-Isidro, J; Munro, I; Galletly, N; McCann, F; Treanor, B; Onfelt, B; Davis, DM; Neil, MAA; French, PMW;
Journal of Physics D: Applied Physics. 2004 37:3296-3303. doi: 10.1088/0022-3727/37/23/011
PMID:

Membrane nanotubes network immune cells
Davis, DM; Onfelt, B; Nedvetzki, S; Vanherberghen, B; McCann, FE; Carlin, LM; Taner, SB; Eleme, K; Treanor, B; de Almeida, C; Williams, G; Nolte, E; Hoen, T; Yanagi, K;
Molecular Biology of the Cell. 2004 15:6A-6A. doi:
PMID:

ADAP-SLP-76 binding differentially regulates supramolecular activation cluster (SMAC) formation relative to T cell-APC conjugation.
Wang, H; McCann, FE; Gordan, JD; Wu, X; Raab, M; Malik, TH; Davis, DM; Rudd, CE;
Journal of Experimental Medicine. 2004 200:1063-1074. doi:
PMID: 15477347

Control of immune responses by trafficking cell surface proteins, vesicles and lipid rafts to and from the immunological synapse.
Taner, SB; Onfelt, B; Pirinen, NJ; McCann, FE; Magee, AI; Davis, DM;
Traffic. 2004 5:651-661. doi:
PMID: 15296490

Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D.
Eleme, K; Taner, SB; Onfelt, B; Collinson, LM; McCann, FE; Chalupny, NJ; Cosman, D; Hopkins, C; Magee, AI; Davis, DM;
Journal of Experimental Medicine. 2004 199:1005-1010. doi:
PMID: 15051759

ADAP-SLP-76 binding regulates supramolecular activation cluster (SMAC) formation and interleukin-2 production
Wang, H; McCann, FE; Wu, X; Davis, DM; Rudd, CE; MEDIMOND, ;
. 2004 :369-374. doi:
PMID:

2003

The protean immune cell synapse: a supramolecular structure with many functions.
Davis, DM; Igakura, T; McCann, FE; Carlin, LM; Andersson, K; Vanherberghen, B; Sjöström, A; Bangham, CR; Höglund, P;
Seminars in Immunology. 2003 15:317-324. doi:
PMID: 15001170

The role of the cytoskeleton and protein size in assembly of the human natural killer cell immune synapse
McCann, FE; Vanherberghen, B; Eleme, K; Collinson, L; Hopkins, C; Davis, DM;
The FASEB Journal. 2003 17:C309-C309. doi:
PMID:

The size of the synaptic cleft and distinct distributions of filamentous actin, ezrin, CD43, and CD45 at activating and inhibitory human NK cell immune synapses.
McCann, FE; Vanherberghen, B; Eleme, K; Carlin, LM; Newsam, RJ; Goulding, D; Davis, DM;
Journal of Immunology. 2003 170:2862-2870. doi:
PMID: 12626536

2002

Imaging immune surveillance by T cells and NK cells.
McCann, FE; Suhling, K; Carlin, LM; Eleme, K; Taner, SB; Yanagi, K; Vanherberghen, B; French, PM; Davis, DM;
Immunological Reviews. 2002 189:179-192. doi:
PMID: 12445274

Probing supramolecular organisation at immune synapses.
McCann, FE; Suhling, K; Carlin, LM; Eleme, K; Yanagi, K; French, PMW; Phillips, D; Davis, DM;
Special Publication- Royal Society of Chemistry. 2002 :58-71. doi: 10.1039/9781847550255-00058
PMID:

Imaging the construction of immunological synapses
Davis, DM; Carlin, LM; Eleme, K; French, PMW; McCann, F; Phillips, D; Siegel, J; Suhling, K; Taner, S; Vanherberghen, B; Webb, S; Yanagi, K;
Tissue Antigens: immune response genetics. 2002 59:3-4. doi:
PMID:

2001

Intercellular transfer and supramolecular organization of human leukocyte antigen C at inhibitory natural killer cell immune synapses.
Carlin, LM; Eleme, K; McCann, FE; Davis, DM;
Journal of Experimental Medicine. 2001 194:1507-1517. doi:
PMID: 11714757

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