Aude Echalier-Glazer

Scientific Coordinator

University of Oxford

Dr Aude Echalier-Glazer is currently the Scientific Coordinator at the SGC Oxford.

Aude received her PhD from the University of Warwick (UK) working on the structural biology of bacterial redox systems. Following five years of post-doctoral research with Prof. Dame Louise Johnson, Prof. Jane Endicott and Prof Martin Noble at the University of Oxford on the structural biology and rational inhibitor development of cell cycle protein kinases, Aude established her research group at the University of Montpellier (France), where she continued her interest in protein kinases and expand her research interests to the ubiquitin system. After five years in France, she moved to the UK, transferred her lab at the University of Leicester for three years. Her work contributed to the Leicester Cancer Research UK Centre. Early 2017, she joined the SGC Oxford as the Scientific Coordinator, where she looks after the Target Enabling Packages initiative and contributes to the Probe programme.

Research Areas

Aude continues her research interest at the University of Leicester focusing on protein kinases and metallo-dependent deubiquitylases using structural and chemical biology to further their characterisation. She is particularly interested in the regulation of protein-protein interaction in the context of phosphorylation and ubiquitylation.

Publications

2017

Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines.
Hylsová, M; Carbain, B; Fanfrlík, J; Musilová, L; Haldar, S; Köprülüoğlu, C; Ajani, H; Brahmkshatriya, PS; Jorda, R; Kryštof, V; Hobza, P; Echalier, A; Paruch, K; Lepšík, M;
European Journal of Medicinal Chemistry. 2017 126:1118-1128. doi: 10.1016/j.ejmech.2016.12.023
PMID: 28039837

2014

An inhibitor's-eye view of the ATP-binding site of CDKs in different regulatory states.
Echalier, A; Hole, AJ; Lolli, G; Endicott, JA; Noble, ME;
ACS Chemical Biology. 2014 9:1251-1256. doi:
PMID: 24669831

Structure and function of MPN (Mpr1/Pad1 N-terminal) domain-containing proteins.
Birol, M; Echalier, A;
Current Protein and Peptide Science. 2014 15:504-517. doi:
PMID: 24555901

Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer.
Birol, M; Enchev, RI; Padilla, A; Stengel, F; Aebersold, R; Betzi, S; Yang, Y; Hoh, F; Peter, M; Dumas, C; Echalier, A;
PLoS One. 2014 9:e105688-. doi: 10.1371/journal.pone.0105688
PMID: 25144743

8-Substituted O(6)-cyclohexylmethylguanine CDK2 inhibitors: using structure-based inhibitor design to optimize an alternative binding mode.
Carbain, B; Paterson, DJ; Anscombe, E; Campbell, AJ; Cano, C; Echalier, A; Endicott, JA; Golding, BT; Haggerty, K; Hardcastle, IR; Jewsbury, PJ; Newell, DR; Noble, ME; Roche, C; Wang, LZ; Griffin, RJ;
Journal of Medicinal Chemistry. 2014 57:56-70. doi:
PMID: 24304238

2013

Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1.
Echalier, A; Pan, Y; Birol, M; Tavernier, N; Pintard, L; Hoh, F; Ebel, C; Galophe, N; Claret, FX; Dumas, C;
Proceedings of the National Academy of Sciences of USA. 2013 110:1273-1278. doi: 10.1073/pnas.1209345110
PMID: 23288897

2012

An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.
Echalier, A; Cot, E; Camasses, A; Hodimont, E; Hoh, F; Jay, P; Sheinerman, F; Krasinska, L; Fisher, D;
Chemistry and Biology. 2012 19:1028-1040. doi: 10.1016/j.chembiol.2012.06.015
PMID: 22921070

2010

Recent developments in cyclin-dependent kinase biochemical and structural studies.
Echalier, A; Endicott, JA; Noble, ME;
Biochimica et Biophysica Acta: international journal of biochemistry and biophysics. 2010 1804:511-519. doi:
PMID: 19822225

2009

The structure of CDK4/cyclin D3 has implications for models of CDK activation.
Takaki, T; Echalier, A; Brown, NR; Hunt, T; Endicott, JA; Noble, ME;
Proceedings of the National Academy of Sciences of USA. 2009 106:4171-4176. doi:
PMID: 19237555

2008

CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases.
Bettayeb, K; Oumata, N; Echalier, A; Ferandin, Y; Endicott, JA; Galons, H; Meijer, L;
Oncogene. 2008 27:5797-5807. doi:
PMID: 18574471

N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine.
Bettayeb, K; Sallam, H; Ferandin, Y; Popowycz, F; Fournet, G; Hassan, M; Echalier, A; Bernard, P; Endicott, J; Joseph, B; Meijer, L;
Molecular Cancer Therapeutics. 2008 7:2713-2724. doi:
PMID: 18790752

Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin complex.
Echalier, A; Bettayeb, K; Ferandin, Y; Lozach, O; Clément, M; Valette, A; Liger, F; Marquet, B; Morris, JC; Endicott, JA; Joseph, B; Meijer, L;
Journal of Medicinal Chemistry. 2008 51:737-751. doi:
PMID: 18232649

Redox-linked structural changes associated with the formation of a catalytically competent form of the diheme cytochrome c peroxidase from Pseudomonas aeruginosa.
Echalier, A; Brittain, T; Wright, J; Boycheva, S; Mortuza, GB; Fülöp, V; Watmough, NJ;
Biochemistry. 2008 47:1947-1956. doi: 10.1021/bi702064f
PMID: 18217775

Structures of P. falciparum protein kinase 7 identify an activation motif and leads for inhibitor design.
Merckx, A; Echalier, A; Langford, K; Sicard, A; Langsley, G; Joore, J; Doerig, C; Noble, M; Endicott, J;
Structure. 2008 16:228-238. doi: 10.1016/j.str.2007.11.014
PMID: 18275814

2007

Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases.
Bettayeb, K; Tirado, OM; Marionneau-Lambot, S; Ferandin, Y; Lozach, O; Morris, JC; Mateo-Lozano, S; Drueckes, P; Schächtele, C; Kubbutat, MH; Liger, F; Marquet, B; Joseph, B; Echalier, A; Endicott, JA; Notario, V; Meijer, L;
Cancer Research. 2007 67:8325-8334. doi:
PMID: 17804748

2006

Searching for cyclin-dependent kinase inhibitors using a new variant of the cope elimination.
Griffin, RJ; Henderson, A; Curtin, NJ; Echalier, A; Endicott, JA; Hardcastle, IR; Newell, DR; Noble, ME; Wang, LZ; Golding, BT;
Journal of the American Chemical Society. 2006 128:6012-6013. doi:
PMID: 16669651

Structure and mechanism in the bacterial dihaem cytochrome c peroxidases.
Pettigrew, GW; Echalier, A; Pauleta, SR;
Journal of Inorganic Biochemistry. 2006 100:551-567. doi: 10.1016/j.jinorgbio.2005.12.008
PMID: 16434100

Activation and catalysis of the di-heme cytochrome c peroxidase from Paracoccus pantotrophus.
Echalier, A; Goodhew, CF; Pettigrew, GW; Fülöp, V;
Structure. 2006 14:107-117. doi: 10.1016/j.str.2005.09.011
PMID: 16407070

2005

Crystal structure and solution NMR dynamics of a D (type II) peroxiredoxin glutaredoxin and thioredoxin dependent: a new insight into the peroxiredoxin oligomerism.
Echalier, A; Trivelli, X; Corbier, C; Rouhier, N; Walker, O; Tsan, P; Jacquot, JP; Aubry, A; Krimm, I; Lancelin, JM;
Biochemistry. 2005 44:1755-1767. doi: 10.1021/bi048226s
PMID: 15697201

2004

Assessing crystallization droplets using birefringence.
Echalier, A; Glazer, RL; Fülöp, V; Geday, MA;
Acta Crystallographica Section D: Biological Crystallography. 2004 60:696-702. doi: 10.1107/S0907444904003154
PMID: 15039558

Crystallization and preliminary X-ray diffraction analysis of a dihaem cytochrome c peroxidase from Paracoccus denitrificans.
Echalier, A; Goodhew, CF; Pettigrew, GW; Fülöp, V;
Acta Crystallographica Section D: Biological Crystallography. 2004 60:331-333. doi: 10.1107/S0907444903026519
PMID: 14747715

Expression, purification, crystallization and preliminary characterization of uridine 5'-diphospho-N-acetylmuramoyl L-alanyl-D-glutamate:lysine ligase (MurE) from Streptococcus pneumoniae 110K/70.
Blewett, AM; Lloyd, AJ; Echalier, A; Fülöp, V; Dowson, CG; Bugg, TD; Roper, DI;
Acta Crystallographica Section D: Biological Crystallography. 2004 60:359-361. doi: 10.1107/S0907444903027720
PMID: 14747725

2002

Oligomeric states of the detergent-solubilized human serum paraoxonase (PON1).
Josse, D; Ebel, C; Stroebel, D; Fontaine, A; Borges, F; Echalier, A; Baud, D; Renault, F; Le Maire, M; Chabrieres, E; Masson, P;
Journal of Biological Chemistry. 2002 277:33386-33397. doi: 10.1074/jbc.M200108200
PMID: 12080042

Crystallization and preliminary X-ray data of a bifunctional peroxiredoxin from poplar.
Echalier, A; Corbier, C; Rouhier, N; Jacquot, JP; Aubry, A;
Acta Crystallographica Section D: Biological Crystallography. 2002 58:1501-1503. doi: 10.1107/S0907444902011782
PMID: 12198315

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