SGC | Annotated Phylogenetic Trees

ATAD2

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Harner14_cmpd5
IC50: 350 µM
Pubmed IDs: 25314628

GSK8814
IC50: 0.08 µM
Pubmed IDs: 27530368

ATAD2B

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GSK8814
IC50: 0.08 µM
Pubmed IDs: 27530368

BAZ2A

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GSK2801
IC50: 0.257 µM
Pubmed IDs: 25799074
http://www.thesgc.org/chemical-probes/GSK2801

BAZ2-ICR
IC50: 0.13 µM
Pubmed IDs: 25719566

BAZ2B

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Ferguson_cmpd40
IC50: 9 µM
Pubmed IDs: 24304323

GSK2801
IC50: 0.136 µM

http://www.thesgc.org/chemical-probes/GSK2801

BAZ2-ICR
IC50: 0.18 µM
Pubmed IDs: 25719566

BRD1

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IACS-9571
IC50: 0.012 µM
Pubmed IDs: 26061247

NI-57
IC50: 0.046 µM
Pubmed IDs: 28714688
28714688

BAY-299
IC50: 0.006 µM
Pubmed IDs: 28402630
http://www.thesgc.org/chemical-probes/BAY-299

BRD2

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JQ1 IC50: 0.017 µM Pubmed IDs: 20871596 http://www.thesgc.org/chemical_probes/JQ1_SGCBD01/#overview	I-BET IC50: 0.032 µM Pubmed IDs: 21068722	hewings_4d IC50: 1.6 µM Pubmed IDs: 21851057
I-BET151 IC50: 0.039 µM Pubmed IDs: 21964340,22437115	chung_cmpd4 IC50: 12.6 µM Pubmed IDs: 22136404	bamborough12_cmpd6a IC50: 0.5 µM Pubmed IDs: 22136469
BIC1 IC50: 28 µM Pubmed IDs: 21513886	seal12_24 IC50: 10 µM Pubmed IDs: 22437115	bamborough12_30 IC50: 2 µM Pubmed IDs: 22136469
bamborough12_31 IC50: 5 µM Pubmed IDs: 22136469	hubert11_46 Patent WO2011054848	hubert11_47 Patent WO2011054848
hubert11_48 Patent WO2011054848	hubert11_49 Patent WO2011054848	hubert11_50 Patent WO2011054848
GW841819X IC50: 0.055 µM Pubmed IDs: 21568322	alprazolam IC50: 2.5 µM Pubmed IDs: 22137933	midazolam Pubmed IDs: 22137933
GSK_Demont_cmpd1 IC50: 0.063 µM WO 2011/054848	RVX-208_Picaud IC50: 0.45 µM Pubmed IDs: 24248379	RVX-208_McLure IC50: 0.09 µM Pubmed IDs: 24391744
Mirguet_cmpd38 IC50: 0.5 µM Pubmed IDs: 24000170	PFI-1 IC50: 0.123 µM Pubmed IDs: 23576556	LY303511 IC50: 7.4 µM Pubmed IDs: 24533473
I-BET726(GSK1324726A) IC50: 0.4 µM Pubmed IDs: 25249180	I-BET762 IC50: 0.035 µM Pubmed IDs: 24015967	MT1 IC50: 0.000024 µM Pubmed IDs: 27775715
MZ1 IC50: 0.228 µM Pubmed IDs: 26035625

BRD3

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I-BET IC50: 0.042 µM Pubmed IDs: 21068722	I-BET151 IC50: 0.032 µM Pubmed IDs: 21964340,22437115	chung_cmpd4 IC50: 6.3 µM Pubmed IDs: 22136404
bamborough12_cmpd6a IC50: 0.5 µM Pubmed IDs: 22136469	BIC1 IC50: 28 µM Pubmed IDs: 21513886	seal12_24 IC50: 10 µM Pubmed IDs: 22437115
bamborough12_30 IC50: 2 µM Pubmed IDs: 22136469	bamborough12_31 IC50: 5 µM Pubmed IDs: 22136469	hubert11_46 Patent WO2011054848
hubert11_47 Patent WO2011054848	hubert11_48 Patent WO2011054848	hubert11_49 Patent WO2011054848
hubert11_50 Patent WO2011054848	GW841819X IC50: 0.055 µM Pubmed IDs: 21568322	alprazolam IC50: 2.5 µM Pubmed IDs: 22137933
midazolam Pubmed IDs: 22137933	GSK_Demont_cmpd2 IC50: 0.1 µM WO 2011/054848	RVX-208_McLure IC50: 0.28 µM Pubmed IDs: 24391744
Mirguet_cmpd38 IC50: 0.3 µM Pubmed IDs: 24000170	Mirguet_cmpd25 IC50: 0.32 µM Pubmed IDs: 24000170	I-BET762 IC50: 0.035 µM Pubmed IDs: 24015967
MT1 IC50: 0.000012 µM Pubmed IDs: 27775715	MZ1 IC50: 0.0115 µM Pubmed IDs: 26035625

BRD4

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JQ1 IC50: 0.033 µM Pubmed IDs: 20871596 http://www.thesgc.org/chemical_probes/JQ1_SGCBD01/#overview	I-BET IC50: 0.04 µM Pubmed IDs: 21068722	miyoshi_cmpnd13 IC50: 0.017 µM Miyoshi et al. WO 2009084693 A1
hewings_4d IC50: 4.8 µM Pubmed IDs: 21851057	I-BET151 IC50: 0.037 µM Pubmed IDs: 21964340,22437115	demont_cmpd6 Patent WO 2011/054848
chung_cmpd4 IC50: 10 µM Pubmed IDs: 22136404	bamborough12_cmpd6a IC50: 0.5 µM Pubmed IDs: 22136469	BIC1 IC50: 28 µM Pubmed IDs: 21513886
seal12_24 IC50: 10 µM Pubmed IDs: 22437115	bamborough12_30 IC50: 2 µM Pubmed IDs: 22136469	bamborough12_31 IC50: 5 µM Pubmed IDs: 22136469
hubert11_46 Patent WO2011054848	hubert11_47 Patent WO2011054848	hubert11_48 Patent WO2011054848
hubert11_49 Patent WO2011054848	hubert11_50 Patent WO2011054848	GW841819X IC50: 0.055 µM Pubmed IDs: 21568322
alprazolam IC50: 2.5 µM Pubmed IDs: 22137933	midazolam Pubmed IDs: 22137933	MS436 IC50: 0.05 µM Pubmed IDs: 24144283
Gehling_cmpd01 IC50: 33 µM DOI: 10.1021/ml4001485	Gehling_cmpd03 IC50: 0.026 µM DOI: 10.1021/ml4001485	Gehling_cmpd11 IC50: 0.29 µM DOI: 10.1021/ml4001485
Gehling_cmpd12 IC50: 0.036 µM DOI: 10.1021/ml4001485	Gehling_cmpd13 IC50: 2.1 µM DOI: 10.1021/ml4001485	Gehling_cmpd14 IC50: 0.086 µM DOI: 10.1021/ml4001485
Gehling_cmpd15 IC50: 0.19 µM DOI: 10.1021/ml4001485	Gehling_cmpd16 IC50: 0.2 µM DOI: 10.1021/ml4001485	Gehling_cmpd17 IC50: 0.19 µM DOI: 10.1021/ml4001485
Gehling_cmpd18 IC50: 0.25 µM DOI: 10.1021/ml4001485	Gehling_cmpd19 IC50: 0.074 µM DOI: 10.1021/ml4001485	Gehling_cmpd20 IC50: 0.25 µM DOI: 10.1021/ml4001485
Gehling_cmpd21 IC50: 0.029 µM DOI: 10.1021/ml4001485	Gehling_cmpd22 IC50: 0.033 µM DOI: 10.1021/ml4001485	Gehling_cmpd23 IC50: 0.042 µM DOI: 10.1021/ml4001485
Gehling_cmpd24 IC50: 0.072 µM DOI: 10.1021/ml4001485	Gehling_cmpd25 IC50: 0.073 µM DOI: 10.1021/ml4001485	Gehling_cmpd26 IC50: 2.5 µM DOI: 10.1021/ml4001485
Gehling_cmpd27 IC50: 5.7 µM DOI: 10.1021/ml4001485	Gehling_cmpd28 IC50: 0.3 µM DOI: 10.1021/ml4001485	Gehling_cmpd29 IC50: 1.1 µM DOI: 10.1021/ml4001485
Gehling_cmpd30 IC50: 6.1 µM DOI: 10.1021/ml4001485	Zaho_cmpd12a IC50: 24 µM Pubmed IDs: 23530754	Zaho_cmpd18b IC50: 4.4 µM Pubmed IDs: 23530754
Zaho_cmpd18d IC50: 4.1 µM Pubmed IDs: 23530754	Zaho_cmpd23b IC50: 23.8 µM Pubmed IDs: 23530754	Zaho_cmpd24b IC50: 3.3 µM Pubmed IDs: 23530754
Zaho_cmpd39 IC50: 2.6 µM Pubmed IDs: 23530754	Zaho_cmpd40a IC50: 0.23 µM Pubmed IDs: 23530754	Zaho_cmpd40b IC50: 2.2 µM Pubmed IDs: 23530754
Zaho_cmpd40c IC50: 0.57 µM Pubmed IDs: 23530754	Zaho_cmpd40d IC50: 0.79 µM Pubmed IDs: 23530754	Mitsubishi_cmpd17 IC50: 0.013 µM WO 2009/084693
DanaFarber_Bradner_JQ13 IC50: 0.002 µM WO 2011143669	Bayer_Schmees_cmpd1 IC50: 0.027 µM WO 2013/030150	Constellation_Albrecht_cmpd28 IC50: 0.1 µM WO 2012/151512
Pfizer_Fish_cmpd1 IC50: 0.05 µM WO 2013/027168	Pfizer_Fish_cmpd2 IC50: 0.05 µM WO 2013/027168	Pfizer_Fish_cmpd3 IC50: 0.05 µM WO 2013/027168
GSK_Demont_cmpd3 IC50: 0.12 µM WO 2011/054848	Constellation_Albrecht_cmpd05 IC50: 0.5 µM WO 2012/174487	Abbvie_Wang_cmpd1 IC50: 0.002 µM WO 2013/097601
Zhou_CM255 IC50: 1 µM US 2012028912	BI2536 IC50: 0.025 µM Pubmed IDs: 24568369	TG101209 IC50: 0.13 µM Pubmed IDs: 24568369
Fedorov_cmpd_51 IC50: 0.2 µM Pubmed IDs: 24313754	RVX-208_McLure IC50: 0.04 µM Pubmed IDs: 24391744	Dittmann_LY294002 IC50: 9 µM Pubmed IDs: 24533473
Hay_cmpd28 IC50: 0.2 µM DOI: 10.1039/C2MD20189E	Lucas_XD14 IC50: 0.237 µM Pubmed IDs: 24272870	Mirguet_cmpd38 IC50: 0.32 µM Pubmed IDs: 24000170
PFI-1 IC50: 0.136 µM Pubmed IDs: 23576556	UMB-32 IC50: 0.55 µM Pubmed IDs: 25314271	OTX015 IC50: 0.02 µM Pubmed IDs: 25623213 http://mct.aacrjournals.org/content/12/11_Supplement/C244.short
Brand15_cmpd8 IC50: 0.02 µM Pubmed IDs: 25549280	BI-2536 IC50: 0.037 µM Pubmed IDs: 24584101	Hewitt15_cmpd23 IC50: 0.017 µM Pubmed IDs: 25851940
Noguchi-Yachide15_cmpd29 IC50: 0.427 µM Pubmed IDs: 25678016	Rosse14_cmpd402 IC50: 0.013 µM http://pubs.acs.org/doi/pdf/10.1021/ml500304a	BRD_BD-1 IC50: 0.015 µM http://pubs.acs.org/doi/pdf/10.1021/ml500411h
Zhao14_cmpd2 IC50: 7 µM Pubmed IDs: 24767840	Zhao15_cmpd39b IC50: 0.46 µM Pubmed IDs: 25559428	amans14_cmpd244_1 IC50: 0.1 µM WO2014/078257, p.244
schmees14_cmpd111 IC50: 0.029 µM WO2014/095774	siegel14_cmpd18.2 IC50: 0.01 µM WO2014/128067	poss14_cmpd2 IC50: 0.05 µM WO2014/134267
fidanze14 IC50: 0.0004 µM WO2014/139324	amans14_cmpd3 IC50: 0.1 µM WO2014/140076	amans14_cmpd32 IC50: 0.01 µM WO2014/140077
albert14_cmpd54 IC50: 0.1 µM WO2014/152029	engelhardt15_cmpdII25 IC50: 0.008 µM WO2015/022332	zhou15 IC50: 0.1 µM WO2015/031824
I-BET762 IC50: 0.035 µM Pubmed IDs: 24015967	dBET1 IC50: 0.02 µM Pubmed IDs: 25999370	BiBET IC50: 0.00001 µM Pubmed IDs: 27775716
MT1 IC50: 0.000062 µM Pubmed IDs: 27775715	MZ1 IC50: 0.12 µM Pubmed IDs: 26035625

BRD7

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BI-7273 IC50: 0.071 µM Pubmed IDs: 27376689	BI-9564 IC50: 0.239 µM Pubmed IDs: 26914985	TP-472 IC50: 0.34 µM http://www.thesgc.org/chemical-probes/TP-472
NI-57 IC50: 0.14 µM Pubmed IDs: 28714688

BRD9

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Fedorov_cmpd_51 IC50: 0.16 µM Pubmed IDs: 24313754	LP99 IC50: 0.099 µM Pubmed IDs: 25864491	I-BRD9 IC50: 0.013 µM Pubmed IDs: 25856009
BI-7273 IC50: 0.021 µM Pubmed IDs: 27376689	BI-9564 IC50: 0.014 µM Pubmed IDs: 26914985	TP-472 IC50: 0.033 µM http://www.thesgc.org/chemical-probes/TP-472
NI-57 IC50: 0.52 µM Pubmed IDs: 28714688

BRDT

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MT1
IC50: 0.000076 µM
Pubmed IDs: 27775715

BRPF1

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Demont14_cmpd11 IC50: 0.05 µM Pubmed IDs: 25408830	IACS-9571 IC50: 0.0021 µM Pubmed IDs: 26061247	igoe17_cmpd13d IC50: 0.013 µM Pubmed IDs: 28068087
PFI-4 IC50: 0.013 µM http://www.thesgc.org/chemical-probes/PFI-4	NI-57 IC50: 0.0031 µM Pubmed IDs: 28714688	GSK6853 IC50: 0.003 µM Pubmed IDs: 27326325

BRPF3

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IACS-9571
IC50: 0.027 µM
Pubmed IDs: 26061247

NI-57
IC50: 0.14 µM
Pubmed IDs: 28714688

CECR2

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Fedorov_cmpd_50
IC50: 0.16 µM
Pubmed IDs: 24313754

Fedorov14_cmpd8
IC50: 0.25 µM
Pubmed IDs: 24313754

NVS-CECR2-1
IC50: 0.08 µM

http://www.thesgc.org/chemical-probes/NVS-1

CREBBP

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MS7972 IC50: 20 µM Pubmed IDs: 16426974	gerona_cmpnd4 IC50: 8 µM Pubmed IDs: 21271695	Ischemin IC50: 19 µM Pubmed IDs: 21513889
hewings11_54 IC50: 32 µM Pubmed IDs: 21851057	Ischemin IC50: 19 µM Pubmed IDs: 21513889	MS7972 IC50: 50 µM Pubmed IDs: 16426974
I-CBP112 IC50: 0.151 µM Pubmed IDs: 26552700 http://www.thesgc.org/chemical-probes/ICBP112	SGC-CBP30 IC50: 0.021 µM Pubmed IDs: 24946055 http://www.thesgc.org/chemical-probes/SGC-CBP30	unzue15_cmpd19 IC50: 0.3 µM Pubmed IDs: 26043365
PF-CBP1 IC50: 0.125 µM http://www.sciencedirect.com/science/article/pii/S1074552115004202	TPOP146 IC50: 0.134 µM Pubmed IDs: 27673482	GNE-272 IC50: 0.02 µM Pubmed IDs: 27682507
GNE-049 IC50: 0.0011 µM Pubmed IDs: 28819026

EP300

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I-CBP112 IC50: 0.625 µM Pubmed IDs: 26552700 http://www.thesgc.org/chemical-probes/ICBP112	SGC-CBP30 IC50: 0.038 µM http://www.thesgc.org/chemical-probes/SGC-CBP30	PF-CBP1 IC50: 0.36 µM http://www.sciencedirect.com/science/article/pii/S1074552115004202
TPOP146 IC50: 0.134 µM Pubmed IDs: 27673482	GNE-272 IC50: 0.03 µM Pubmed IDs: 27682507	GNE-049 IC50: 0.0023 µM Pubmed IDs: 28819026

KAT2A

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L-45/L-Moses
IC50: 0.55 µM
Pubmed IDs: 27966810

GSK4027
IC50: 0.0014 µM
Pubmed IDs: 28002667

KAT2B

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zeng05_cmpd2 IC50: 1.6 µM Pubmed IDs: 15724976	pan07_cmpnd8 IC50: 1 µM Pubmed IDs: 17444627	Hu_cmpd15 IC50: 1.18 µM Pubmed IDs: 24474698
Wang_cmpd02 IC50: 2 µM DOI: 10.1039/c3md20376j	L-45/L-Moses IC50: 0.126 µM Pubmed IDs: 27966810	GSK4027 IC50: 0.0014 µM Pubmed IDs: 28002667

PBRM1

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PFI-3
IC50: 0.048 µM

http://advances.sciencemag.org/content/1/10/e1500723.abstract

myrianthopoulos16_cmpd11
IC50: 3.3 µM
Pubmed IDs: 27617704

SMARCA4

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PFI-3
IC50: 0.089 µM
Pubmed IDs: 26139243
http://advances.sciencemag.org/content/1/10/e1500723.abstract

TAF1

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UMB-32
IC50: 0.56 µM
Pubmed IDs: 25314271

CeMMEC13
IC50: 2.1 µM
Pubmed IDs: 27159579

BAY-299
IC50: 0.013 µM
Pubmed IDs: 28402630
http://www.thesgc.org/chemical-probes/BAY-299

TAF1L

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UMB-32
IC50: 1.3 µM
Pubmed IDs: 25314271

BAY-299
IC50: 0.106 µM
Pubmed IDs: 28402630
http://www.thesgc.org/chemical-probes/BAY-299

TRIM24

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IACS-9571
IC50: 0.0013 µM
Pubmed IDs: 26061247