SGC | Annotated Phylogenetic Trees

JHDM1D/KIAA1718

E67-2 IC50: 3.4 µM Pubmed IDs: 22227394	suzuki13_cmpd9 IC50: 0.2 µM Pubmed IDs: 23964788	Daminozide Rose2012_cmpd19 IC50: 2.1 µM Pubmed IDs: 22724510
gerken17_cmpd6 IC50: 0.19 µM Pubmed IDs: 28976073

KDM1A/LSD1

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tranylcypromine IC50: 2 µM Pubmed IDs: 16793513,22406747	ueda09_cmpd2 IC50: 1.9 µM Pubmed IDs: 19950987	binda10_cmpd13b IC50: 1.1 µM Pubmed IDs: 20415477
binda10_cmpd14c IC50: 1.3 µM Pubmed IDs: 20415477	mimasu10_S2101 IC50: 1 µM Pubmed IDs: 20568732	Ortega11_cmpd10 IC50: 0.1 µM patent: WO2011035941A1
Ortega_OG-L002 IC50: 0.02 µM Pubmed IDs: 23386436	Example_5 IC50: 0.022 µM WO2013057320	Hitchin2013_cmpd24 IC50: 0.04 µM Med. Chem. Commun., 2013, 4, 1513-1522
Bizine - Prusevich2014_cmpd12d IC50: 0.059 µM Pubmed IDs: 24707965	GSK345 Hitchin2013_cmpd25 IC50: 0.09 µM Med. Chem. Commun., 2013, 4, 1513-1522	Ye2014_cmpd8k IC50: 0.39 µM Med. Chem. Commun.,2014, 5,650:654
Zheng_cmpd26 IC50: 2.1 µM Pubmed IDs: 24131029	Rotili2014_cmpd1 IC50: 2.2 µM Pubmed IDs: 24325601	Hitchin2013_cmpd16k IC50: 7.5 µM Med. Chem. Commun., 2013, 4, 1513-1522
Dulla_cmpd_9a IC50: 9.5 µM Pubmed IDs: 23575971	Hitchin2013_cmpd16q IC50: 9.5 µM Med. Chem. Commun., 2013, 4, 1513-1522	Hitchin2013_cmpd19c IC50: 10.2 µM Med. Chem. Commun., 2013, 4, 1513-1522
Sakane, 14,15-dihydro GGA IC50: 22 µM Pubmed IDs: 24406160	Schmitt2013_cmpd5f IC50: 22 µM Pubmed IDs: 24007511	Sorna2013_cmpd12 IC50: 0.013 µM Pubmed IDs: 24237195
GSK-LSD1 IC50: 0.016 µM Pubmed IDs: 26175415 http://www.thesgc.org/chemical-probes/LSD1	OG-L002 IC50: 0.02 µM Pubmed IDs: 23386436	khan15_cmpd15 IC50: 0.38 µM http://pubs.rsc.org/en/content/articlelanding/2015/md/c4md00330f#!divAbstract
ma15_cmpd6b IC50: 0.65 µM Pubmed IDs: 25610955 25610955	nowotarski15_cmpd6d IC50: 5 µM Pubmed IDs: 25725609 25725609	valente15_cmpd11a IC50: 0.013 µM Pubmed IDs: 25768700 25768700
vianello14_cmpd19e IC50: 0.617 µM Pubmed IDs: 25173853 25173853	harris12_cmpdB IC50: 0.098 µM Pubmed IDs: 22464800	GSK2879552 IC50: 1.7 µM Pubmed IDs: 26175415
T-3775440 IC50: 0.02 µM Pubmed IDs: 27903753

KDM2A/FBXL11

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Daminozide Rose2012_cmpd19 IC50: 1.5 µM Pubmed IDs: 22724510	Rotili2014_cmpd1 IC50: 0.22 µM Pubmed IDs: 24325601	HTS12214 IC50: 1.5 µM Pubmed IDs: 25883088
gerken17_cmpd6 IC50: 0.16 µM Pubmed IDs: 28976073

KDM2B/FBXL10

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england14_cmpd35 IC50: 0.063 µM http://pubs.rsc.org/en/content/articlelanding/2014/md/c4md00291a#!divAbstract	nie14_cmpd158 IC50: 0.1 µM WO2014/089364	kanouni14_cmpd1 IC50: 0.1 µM WO2014/151945
kanouni14_cmpd1b IC50: 0.1 µM WO2014/151945	kanouni14_cmpd141 IC50: 0.1 µM WO2014/151945

KDM3A/JMJD1A

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Rotili2014_cmpd1
IC50: 0.14 µM
Pubmed IDs: 24325601

KDM5-C49
IC50: 0.78 µM
Pubmed IDs: 27214403

KDM4A/JMJD2A

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2,4-PDCA IC50: 0.6 µM Pubmed IDs: 21124847	sid_85736331 IC50: 1.7 µM Pubmed IDs: 21124847	sid_852641 IC50: 8.2 µM Pubmed IDs: 21124847
luo2011_cmpd1 IC50: 4.3 µM Pubmed IDs: 21585201	rose10_cmpd7f IC50: 12 µM Pubmed IDs: 20088513	NCDM-32 IC50: 3 µM Pubmed IDs: 20684604
JIB-04 IC50: 0.44 µM Pubmed IDs: 23792809	labelle06_epitherapeutics_Example49 IC50: 0.1 µM WO2014053491A1_Epitherapeeutics	labelle06_epitherapeutics_Example48 IC50: 0.1 µM WO2014053491A1_Epitherapeeutics
kanouni14_cmpd1 IC50: 0.1 µM WO2014/151945	kanouni14_cmpd1b IC50: 0.1 µM WO2014/151945	NCGC00244536 IC50: 1 µM Pubmed IDs: 26364928
bavetsias16_cmpd54j IC50: 0.08 µM Pubmed IDs: 26741168	westaway16_cmpd41 IC50: 0.64 µM Pubmed IDs: 26771203	HTS12214 IC50: 0.3 µM Pubmed IDs: 25883088

KDM4B/JMJD2B

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JIB-04 IC50: 0.43 µM Pubmed IDs: 23792809	labelle06_epitherapeutics_Example49 IC50: 0.1 µM WO2014053491A1_Epitherapeeutics	labelle06_epitherapeutics_Example48 IC50: 0.1 µM WO2014053491A1_Epitherapeeutics
NCGC00244536 IC50: 0.01 µM Pubmed IDs: 26364928	bavetsias16_cmpd54j IC50: 0.017 µM Pubmed IDs: 26741168

KDM4C/JMJD2C

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luo2011_cmpd1 IC50: 3.4 µM Pubmed IDs: 21585201	NCDM-32 IC50: 1 µM Pubmed IDs: 20684604	JIB-04 IC50: 1.1 µM Pubmed IDs: 23792809
Rotili2014_cmpd1 IC50: 0.07 µM Pubmed IDs: 24325601	labelle06_epitherapeutics_Example49 IC50: 0.1 µM WO2014053491A1_Epitherapeeutics	labelle06_epitherapeutics_Example48 IC50: 0.1 µM WO2014053491A1_Epitherapeeutics
itoh15_cmpd6j IC50: 43 µM http://pubs.acs.org/doi/abs/10.1021/acsmedchemlett.5b00083	nie14_cmpd156 IC50: 0.1 µM WO2014/089364	kanouni14_cmpd73 IC50: 0.1 µM WO2014/100463
chen14_cmpd80 IC50: 1 µM WO2014/100818	chen14_cmpd3 IC50: 0.1 µM WO2014/100818	kanouni14_cmpd87 IC50: 1 µM WO2014/151106
kanouni14_cmpd113 IC50: 0.1 µM WO2014/151106	kanouni14_cmpd1 IC50: 0.1 µM WO2014/151945	kanouni14_cmpd1b IC50: 0.1 µM WO2014/151945
coleman14_cmpd130 IC50: 0.1 µM WO2014/14708	coleman14_cmpd142 IC50: 0.1 µM WO2014/14708	KDM5-C49 IC50: 0.21 µM Pubmed IDs: 27214403
schiller14_cmpd5 IC50: 3.9 µM Pubmed IDs: 24504543	NCGC00244536 IC50: 1 µM Pubmed IDs: 26364928	labelle12_cmpd IC50: 0.5 µM WO2012007008
westaway16_cmpd41 IC50: 0.5 µM Pubmed IDs: 26771203

KDM4D/JMJD2D

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JIB-04
IC50: 0.3 µM
Pubmed IDs: 23792809

westaway16_cmpd41
IC50: 0.4 µM
Pubmed IDs: 26771203

fang17_cmpd10r
IC50: 0.41 µM
Pubmed IDs: 28539219

KDM4DL/JMJD2E

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2,4-PDCA IC50: 1.4 µM Pubmed IDs: 18942826	rose08_cmpd7 IC50: 6.6 µM Pubmed IDs: 18942826	rose08_cmpd5a IC50: 4.8 µM Pubmed IDs: 18942826
sid_85736397 IC50: 2 µM Pubmed IDs: 21124847	sid_85736331 IC50: 2.4 µM Pubmed IDs: 21124847	sid_852641 IC50: 6 µM Pubmed IDs: 21124847
chang11_cmpd15c IC50: 0.11 µM Pubmed IDs: 21412984	luo2011_cmpd1 IC50: 5.9 µM Pubmed IDs: 21585201	thalhammer_47 IC50: 2.5 µM Pubmed IDs: 21076780
chang11_cmpd13a IC50: 0.18 µM Pubmed IDs: 21412984	rose10_cmpd7f IC50: 5.4 µM Pubmed IDs: 20088513	JIB-04 IC50: 0.34 µM Pubmed IDs: 23792809
Rotili2014_cmpd1 IC50: 0.42 µM Pubmed IDs: 24325601

KDM5A/JARID1A

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JIB-04 IC50: 0.23 µM Pubmed IDs: 23792809	itoh15_cmpd6j IC50: 3.3 µM http://pubs.acs.org/doi/abs/10.1021/acsmedchemlett.5b00083	nie14_cmpd89 IC50: 0.1 µM WO2014/089364
nie14_cmpd156 IC50: 0.1 µM WO2014/089364	kanouni14_cmpd73 IC50: 0.1 µM WO2014/100463	chen14_cmpd3 IC50: 0.1 µM WO2014/100818
kanouni14_cmpd87 IC50: 0.1 µM WO2014/151106	kanouni14_cmpd113 IC50: 0.1 µM WO2014/151106	kanouni14_cmpd1 IC50: 0.1 µM WO2014/151945
kanouni14_cmpd1b IC50: 0.1 µM WO2014/151945	albrecht14_cmpd2 IC50: 0.003 µM WO2014/139326	albrecht15_cmpd11 IC50: 0.0023 µM US2015/0065522
CPI-455 IC50: 0.01 µM Pubmed IDs: 27214401	KDM5-C49 IC50: 0.007 µM Pubmed IDs: 27214403	GSK467 IC50: 0.024 µM Pubmed IDs: 27214403
albrecht14_cmpd IC50: 0.015 µM WO2014139326 WO2015135094	KDOAM-25 IC50: 0.071 µM Pubmed IDs: 28262558	liang17_cmpd50 IC50: 0.045 µM Pubmed IDs: 28512031
vazquez18_cmpd9 IC50: 0.05 µM Pubmed IDs: 30431220

KDM5B/JARID1B

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labelle06_epitherapeutics_Example49 IC50: 0.1 µM WO2014053491A1_Epitherapeeutics	labelle06_epitherapeutics_Example48 IC50: 0.1 µM WO2014053491A1_Epitherapeeutics	GSK-J1 IC50: 0.17 µM Pubmed IDs: 25279926 http://www.thesgc.org/chemical-probes/GSKJ1
nie14_cmpd89 IC50: 0.1 µM WO2014/089364	nie14_cmpd156 IC50: 0.1 µM WO2014/089364	kanouni14_cmpd73 IC50: 0.1 µM WO2014/100463
chen14_cmpd3 IC50: 0.1 µM WO2014/100818	kanouni14_cmpd87 IC50: 0.1 µM WO2014/151106	kanouni14_cmpd113 IC50: 0.1 µM WO2014/151106
kanouni14_cmpd1 IC50: 0.1 µM WO2014/151945	kanouni14_cmpd1b IC50: 0.1 µM WO2014/151945	coleman14_cmpd142 IC50: 0.1 µM WO2014/14708
CPI-455 IC50: 0.03 µM Pubmed IDs: 27214401	KDM5-C49 IC50: 0.004 µM Pubmed IDs: 27214403	GSK467 IC50: 0.026 µM Pubmed IDs: 27214403
bavetsias16_cmpd54j IC50: 0.014 µM Pubmed IDs: 26741168	KDOAM-25 IC50: 0.019 µM Pubmed IDs: 28262558	liang17_cmpd50 IC50: 0.056 µM Pubmed IDs: 28512031
vazquez18_cmpd9 IC50: 0.065 µM https://chemrxiv.org/articles/Design_Synthesis_and_Characterization_of_Covalent_KDM5_Inhibitors/7072592

KDM5C/JARID1C

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Rotili2014_cmpd1 IC50: 0.07 µM Pubmed IDs: 24325601	labelle06_epitherapeutics_Example49 IC50: 0.1 µM WO2014053491A1_Epitherapeeutics	labelle06_epitherapeutics_Example48 IC50: 0.1 µM WO2014053491A1_Epitherapeeutics
labelle06_epitherapeutics_Example1 IC50: 0.1 µM WO2014053491A1_Epitherapeeutics	GSK-J1 IC50: 0.55 µM Pubmed IDs: 25279926 http://www.thesgc.org/chemical-probes/GSKJ1	CPI-455 IC50: 0.01 µM Pubmed IDs: 27214401
KDM5-C49 IC50: 0.013 µM Pubmed IDs: 27214403	GSK467 IC50: 0.065 µM Pubmed IDs: 27214403	bavetsias16_cmpd54j IC50: 0.051 µM Pubmed IDs: 26741168
westaway16_cmpd41 IC50: 0.079 µM Pubmed IDs: 26771203	KDOAM-25 IC50: 0.069 µM Pubmed IDs: 28262558	liang17_cmpd50 IC50: 0.055 µM Pubmed IDs: 28512031

KDM5D/JARID1D

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KDM5-C49
IC50: 0.015 µM
Pubmed IDs: 27214403

GSK467
IC50: 0.077 µM
Pubmed IDs: 27214403

KDOAM-25
IC50: 0.069 µM
Pubmed IDs: 28262558

KDM6A/UTX

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GSK-J1
IC50: 0.053 µM
Pubmed IDs: 25279926
http://www.thesgc.org/chemical-probes/GSKJ1

KDM6B/JMJD3

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GSK-J1
IC50: 0.06 µM
Pubmed IDs: 22842901
http://www.thesgc.org/chemical-probes/GSKJ1

JIB-04
IC50: 0.85 µM
Pubmed IDs: 23792809

PHF8

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luo2011_cmpd1
IC50: 10 µM
Pubmed IDs: 21585201

Daminozide Rose2012_cmpd19
IC50: 0.55 µM
Pubmed IDs: 22724510

itoh15_cmpd6j
IC50: 73 µM

http://pubs.acs.org/doi/abs/10.1021/acsmedchemlett.5b00083