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Team Leader Protein Science
Opher Gileadi is heading the Protein Science team at the Structural Genomics Consortium (SGC) unit at the Karolinska Institute, Sweden. Opher obtained his PhD at the Hebrew University in Jerusalem, followed by a postdoc at Stanford and a Senior Scientist at the Weizmann Institute, where he investigated mechanisms of transcription in yeast. He was one of the founding group leaders of the SGC at the University of Oxford (2004), where his team established a pipeline of cloning and expression of human proteins for structural studies, resulting in more than 800 new protein structures. His group studied a diverse selection of proteins, including DNA helicases and nucleases, transcription factors, protein kinases, signalling proteins and genes linked to Alzheimer’s disease. The SGC is strongly committed to providing basic knowledge on under-studied human proteins, enabling their evaluation as potential drug targets and generating the key reagent to initiate small-molecule development. In the CMM, Opher is focussing on proteins involved in inflammatory and autoimmune disorders.
Current Duties
Opher leads the Protein Science team at SGC Karolinska, focussing on developing antibodies and target-enabling packages (TEPs) for under-investigated proteins of humans and pathogens.
2024
PLoS One. 19.04.2024 19(2):e0293548. doi: 10.1371/journal.pone.0293548
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2023
Science. 10.11.2023 382(6671):eabo7201. doi: 10.1126/science.abo7201
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J Biol Chem. 20.10.2023 105382. doi: 10.1016/j.jbc.2023.105382
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Alzheimers Dement (N Y). 22.05.2023 9(2):e12394. doi: 10.1002/trc2.12394
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2021
Sci Adv. 03.12.2021 7(49):eabj9247. doi: 10.1126/sciadv.abj9247
PMID: 34860543
Nat Commun. 11.08.2021 12(1):4848. doi: 10.1038/s41467-021-25166-6
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2020
Life Sci Alliance. 18.11.2020 4(1):. doi: 10.26508/lsa.202000795
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Methods Mol Biol. 31.10.2020 2199:67-94. doi: 10.1007/978-1-0716-0892-0_5
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Methods Mol Biol. 31.10.2020 2199:45-66. doi: 10.1007/978-1-0716-0892-0_4
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Methods Mol Biol. 31.10.2020 2199:23-43. doi: 10.1007/978-1-0716-0892-0_3
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Essays Biochem. 26.10.2020 64(5):819-830. doi: 10.1042/EBC20200012
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DNA Repair (Amst.). 31.07.2020 95:102941. doi: 10.1016/j.dnarep.2020.102941
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Life science alliance. 30.06.2020 3:-. doi: 10.26508/lsa.202000725
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Life Sci Alliance. 30.05.2020 3(7):. doi: 10.26508/lsa.202000725
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ACS Med Chem Lett. 12.03.2020 11(3):340-345. doi: 10.1021/acsmedchemlett.9b00399
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2019
J. Biol. Chem.. 30.12.2019 . doi: 10.1074/jbc.RA119.010365
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Sci Rep. 11.11.2019 9(1):16452. doi: 10.1038/s41598-019-52795-1
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Scientific reports. 11.11.2019 9:16452-. doi: 10.1038/s41598-019-52795-1
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ACS Medicinal Chemistry Letters. 29.10.2019 . doi: 10.1021/acsmedchemlett.9b00399
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Front Plant Sci. 18.10.2019 10:1105. doi: 10.3389/fpls.2019.01105
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Elife. 15.10.2019 8:. doi: 10.7554/eLife.48363
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J. Med. Chem.. 24.09.2019 . doi: 10.1021/acs.jmedchem.9b00562
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Journal of Medicinal Chemistry. 23.09.2019 62:9008-9025. doi: 10.1021/acs.jmedchem.9b00562
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Frontiers in Plant Science. 16.09.2019 10:1105-. doi: 10.3389/fpls.2019.01105
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ACS Medicinal Chemistry Letters. 12.09.2019 10:1266-1271. doi: 10.1021/acsmedchemlett.9b00082
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ACS Med Chem Lett. 12.09.2019 10(9):1266-1271. doi: 10.1021/acsmedchemlett.9b00082
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Cell Rep. 02.01.2019 26(1):79-93.e8. doi: 10.1016/j.celrep.2018.12.023
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2018
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Journal of Molecular Biology. 01.3.2018 430:722-736. doi: 10.1016/j.jmb.2017.12.018
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2017
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Biophysical Journal. 3.2.2017 112:340A-340A. doi: 10.1016/j.bpj.2016.11.1840
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Nucleic Acids Res.. 18.01.2017 . doi: 10.1093/nar/gkw1362
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2016
Mol. Cell. 17.11.2016 64(4):704-719. doi: 10.1016/j.molcel.2016.09.032
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Chem. Commun. (Camb.). 28.04.2016 . doi: 10.1039/c6cc00529b
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Biophysical Journal. 16.2.2016 110:535A-535A. doi: 10.1016/j.bpj.2015.11.2862
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Nucleic Acids Res.. 29.01.2016 . doi: 10.1093/nar/gkw050
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Nat. Cell Biol.. 25.01.2016 . doi: 10.1038/ncb3303
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J. Med. Chem.. 07.01.2016 . doi: 10.1021/acs.jmedchem.5b01635
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2015
J. Med. Chem.. 23.12.2015 . doi: 10.1021/acs.jmedchem.5b01527
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Structure. 01.12.2015 23(12):2319-30. doi: 10.1016/j.str.2015.10.014
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Nucleic Acids Res.. 17.11.2015 . doi: 10.1093/nar/gkv1256
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Nucleic Acids Research. 1.9.2015 43:247-258. doi: 10.1093/nar/gku1279
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J. Biol. Chem.. 12.04.2015 . doi: 10.1074/jbc.M115.646737
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Journal of Biological Chemistry. 01.5.2015 290:13692-13709. doi: 10.1074/jbc.M115.646737
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Proc. Natl. Acad. Sci. U.S.A.. 23.03.2015 . doi: 10.1073/pnas.1417594112
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Journal of Biological Chemistry. 01.3.2015 290:8539-8549. doi: 10.1074/jbc.M114.619270
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2014
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Nat Commun. 25.11.2014 5:5556. doi: 10.1038/ncomms6556
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The Journal of biological chemistry. 27/06/2014 289(26):18302-18313. doi: http://dx.doi.org/10.1074/jbc.M114.555052
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Journal of Biological Chemistry. 01.6.2014 289:18302-18313. doi: 10.1074/jbc.M114.555052
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Epigenomics. 04.03.2014 6(1):89-120. doi: 10.2217/epi.13.79
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Biochem. Soc. Trans.. 01.02.2014 42(1):130-8. doi: 10.1042/BST20130227
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2013
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Methods Mol. Biol.. 10.11.2013 1091:95-121. doi: 10.1007/978-1-62703-691-7_6
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Bioorganic and Medicinal Chemistry Letters. 01.01.2013 :-. doi: 10.1016/j.bmcl.2013.08.025
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Bioorg. Med. Chem. Lett.. 13.08.2013 . doi: 10.1016/j.bmcl.2013.08.025
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Structure. 18.06.2013 . doi: 10.1016/j.str.2013.05.001
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Proc. Natl. Acad. Sci. U.S.A.. 11.06.2013 110(24):9710-5. doi: 10.1073/pnas.1217042110
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Haematologica. 28.05.2013 . doi: 10.3324/haematol.2013.089490
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Haematologica. 01.9.2013 98:1383-1387. doi: 10.3324/haematol.2013.089490
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J. Biol. Chem.. 15.03.2013 288(11):7803-14. doi: 10.1074/jbc.M112.437996
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PLoS ONE. 07.03.2013 8(3):e57644. doi: 10.1371/journal.pone.0057644
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Chem. Biol.. 24.01.2013 20(1):55-62. doi: 10.1016/j.chembiol.2012.10.016
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2012
Am. J. Hum. Genet.. 02.11.2012 91(5):897-905. doi: 10.1016/j.ajhg.2012.08.027
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American Journal of Human Genetics. 2.11.2012 91:897-905. doi: 10.1016/j.ajhg.2012.08.027
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European Journal of Cancer. 01.11.2012 48:85-85. doi: 10.1016/S0959-8049(12)72074-9
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J. Mol. Biol.. 07.09.2012 422(1):3-17. doi: 10.1016/j.jmb.2012.04.031
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J. Biol. Chem.. 27.07.2012 287(31):26254-67. doi: 10.1074/jbc.M112.367243
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J. Med. Chem.. 26.07.2012 55(14):6639-43. doi: 10.1021/jm300677j
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N Biotechnol. 15.06.2012 29(5):515-25. doi: 10.1016/j.nbt.2011.10.007
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J. Biol. Chem.. 03.02.2012 287(6):4121-8. doi: 10.1074/jbc.M111.285395
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2011
J. Biol. Chem.. 02.12.2011 286(48):41616-25. doi: 10.1074/jbc.M111.283689
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Genes Dev.. 01.09.2011 25(17):1859-70. doi: 10.1101/gad.15699211
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Genes and Development. 1.9.2011 25:1859-1870. doi: 10.1101/gad.15699211
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J. Biol. Chem.. 15.04.2011 286(15):13261-71. doi: 10.1074/jbc.M110.206771
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J. Inherit. Metab. Dis.. 29.03.2011 34(3):671-6. doi: 10.1007/s10545-011-9294-8
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Anal. Biochem.. 15.03.2011 410(2):272-80. doi: 10.1016/j.ab.2010.11.008
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Journal of Inherited Metabolic Disease. 01.01.2011 34:S119-S119. doi:
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2010
J. Biol. Chem.. 03.12.2010 285(49):38204-13. doi: 10.1074/jbc.M110.177717
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Analytical Biochemistry. 17.11.2010 :-. doi: 10.1016/j.ab.2010.11.008
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Nucleic Acids Res.. 08.11.2010 39(5):1703-17. doi: 10.1093/nar/gkq1031
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Proc. Natl. Acad. Sci. U.S.A.. 13.07.2010 107(28):12593-8. doi: 10.1073/pnas.0909087107
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J. Struct. Biol.. 10.06.2010 172(1):3-13. doi: 10.1016/j.jsb.2010.06.008
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Protein Science. 01.4.2010 19:731-741. doi: 10.1002/pro.349
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Biophys. Chem.. 20.03.2010 149(3):67-77. doi: 10.1016/j.bpc.2010.03.012
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2009
Proc. Natl. Acad. Sci. U.S.A.. 27.01.2009 106(4):1039-44. doi: 10.1073/pnas.0806908106
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2008
Methods Mol. Biol.. 11.06.2008 426:221-46. doi: 10.1007/978-1-60327-058-8_14
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Proceedings of the National Academy of Sciences. 23.4.2008 105:6457-6462. doi: 10.1073/pnas.0801508105
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Nat. Methods. 01.02.2008 5(2):135-46. doi: 10.1038/nmeth.f.202
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Protein Expr. Purif.. 26.01.2008 59(1):94-102. doi: 10.1016/j.pep.2008.01.008
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Methods in Molecular Biology. 1.1.2008 439:269-289. doi: 10.1007/978-1-59745-188-8_19
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2007
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Protein Science. 01.4.2007 16:683-694. doi:
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J. Biol. Chem.. 02.02.2007 282(5):3077-82. doi: 10.1074/jbc.M608179200
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2006
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2005
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2004
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Toxicologic Pathology. 01.5.2004 32:357-363. doi: 10.1080/01926230490431772
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Proceedings of the National Academy of Sciences. 9.3.2004 101:3346-3351. doi: 10.1073/pnas.0400088101
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Ultrastructural Pathology. 01.1.2004 28:29-31. doi:
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2003
Biological Bulletin. 01.10.2003 205:177-179. doi: 10.2307/1543239
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Microscopy and Microanalysis. 30.10.2003 9:486-487. doi:
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2002
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2001
Applied Optics. 1.11.2001 40:5650-5657. doi:
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EMBO Journal. 1.3.2001 20:1099-1113. doi: 10.1093/emboj/20.5.1099
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2000
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BBA - Biochimica et Biophysica Acta. 25.4.2000 1491:37-48. doi:
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1999
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1998
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1995
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1994
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1993
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1992
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1988
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