Jinrong Min

Principal Investigator

University of Toronto
+1 416 9463868

Jinrong Min obtained his PhD degree in physics at the Chinese Academy of Sciences, and carried out his post-doctoral training in chromatin structural biology at the Cold Spring Harbor Laboratory. Jinrong is currently an Associate Professor in the Department of Physiology at the University of Toronto, and leading the Chromatin Structural Biology and Epigenetics Group at the Structural Genomics Consortium (SGC), University of Toronto. Our overarching goal is to characterize chromatin proteins systematically by X-ray crystallography in combination with other biochemical and biophysical techniques.

Research Areas

Research in the chromatin structural biology group consists of: 1) Chromatin modifying enzymes: Chromatin structure is very dynamic, and is governed by different chromatin modifying activities such as: DNA methylation, histone modifications, and ATP-dependent chromatin remodeling. My laboratory is trying to understand the mechanisms of catalysis and inhibition of these chromatin modifying enzymes. 2) Regulation and recruitment of chromatin modifying activities: Regulation and recruitment of chromatin-modifying activities is critical for establishing and maintaining normal gene expression patterns, and aberrant gene expression is linked to many human diseases, such as various genetic diseases and cancers. Chromatin-modifying activities have been relatively well characterized, but the mechanisms of regulation and recruitment of chromatin-modifying activities are poorly understood. One major focus of my laboratory is to identify and characterize the recruitment and regulation mechanisms of the chromatin modifying activities. 3) Structure-Based Drug Discovery: Epigenetic abnormalities play an important role in the pathogenesis of cancer and other genetic diseases. Therefore, proteins involved in chromatin modifications are attractive therapeutic targets for drug design. We are screening and designing small molecules that can inhibit chromatin-regulating proteins in collaboration with medicinal chemists.

Group Members

  • Heng Zhang
  • Cheng Dong
  • Johnny Li
  • Ming Lei
  • Gamze Ayaz
Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly.
Xu C, Ishikawa H, Izumikawa K, Li L, He H, Nobe Y, Yamauchi Y, Shahjee HM, Wu XH, Yu YT, Isobe T, Takahashi N, Min J
Genes Dev.. 2016 30(21):2376-2390. doi: 10.1101/gad.288340.116
PMID: 27881600

Structural biology: HDAC6 finally crystal clear.
Liu Y, Li L, Min J
Nat. Chem. Biol.. 2016 12(9):660-1. doi: 10.1038/nchembio.2158
PMID: 27538024

PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3.
Chung HR, Xu C, Fuchs A, Mund A, Lange M, Staege H, Schubert T, Bian C, Dunkel I, Eberharter A, Regnard C, Klinker H, Meierhofer D, Cozzuto L, Winterpacht A, DiCroce L, Min J, Will H, Kinkley S
Elife. 2016 5:. doi: 10.7554/eLife.10607
PMID: 27223324

Structural basis for substrate recognition by the human N-terminal methyltransferase 1.
Dong C, Mao Y, Tempel W, Qin S, Li L, Loppnau P, Huang R, Min J
Genes Dev.. 2015 . doi: 10.1101/gad.270611.115
PMID: 26543161

RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.
Ni Z, Xu C, Guo X, Hunter GO, Kuznetsova OV, Tempel W, Marcon E, Zhong G, Guo H, Kuo WH, Li J, Young P, Olsen JB, Wan C, Loppnau P, El Bakkouri M, Senisterra GA, He H, Huang H, Sidhu SS, Emili A, Murphy S, Mosley AL, Arrowsmith CH, Min J, Greenblatt JF
Nat. Struct. Mol. Biol.. 2014 . doi: 10.1038/nsmb.2853
PMID: 24997600

Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1.
Qin S, Liu Y, Tempel W, Eram MS, Bian C, Liu K, Senisterra G, Crombet L, Vedadi M, Min J
Nat Commun. 2014 5:3952. doi: 10.1038/ncomms4952
PMID: 24853335

Structural basis for selective binding of m(6)A RNA by the YTHDC1 YTH domain.
Xu C, Wang X, Liu K, Roundtree IA, Tempel W, Li Y, Lu Z, He C, Min J
Nat. Chem. Biol.. 2014 . doi: 10.1038/nchembio.1654
PMID: 25242552

Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development.
Xu Y, Xu C, Kato A, Tempel W, Abreu JG, Bian C, Hu Y, Hu D, Zhao B, Cerovina T, Diao J, Wu F, He HH, Cui Q, Clark E, Ma C, Barbara A, Veenstra GJ, Xu G, Kaiser UB, Liu XS, Sugrue SP, He X, Min J, Kato Y, Shi YG
Cell. 2012 151(6):1200-13. doi: 10.1016/j.cell.2012.11.014
PMID: 23217707

Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock.
Xu C, Jin J, Bian C, Lam R, Tian R, Weist R, You L, Nie J, Bochkarev A, Tempel W, Tan CS, Wasney GA, Vedadi M, Gish GD, Arrowsmith CH, Pawson T, Yang XJ, Min J
Sci Signal. 2012 5(226):ra39. doi: 10.1126/scisignal.2002979
PMID: 22649097

Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2.
Zheng W, Ibáñez G, Wu H, Blum G, Zeng H, Dong A, Li F, Hajian T, Allali-Hassani A, Amaya MF, Siarheyeva A, Yu W, Brown PJ, Schapira M, Vedadi M, Min J, Luo M
J. Am. Chem. Soc.. 2012 134(43):18004-14. doi: 10.1021/ja307060p
PMID: 23043551

Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation.
Bian C, Xu C, Ruan J, Lee KK, Burke TL, Tempel W, Barsyte D, Li J, Wu M, Zhou BO, Fleharty BE, Paulson A, Allali-Hassani A, Zhou JQ, Mer G, Grant PA, Workman JL, Zang J, Min J
EMBO J.. 2011 30(14):2829-42. doi: 10.1038/emboj.2011.193
PMID: 21685874

Structural basis for the recognition and cleavage of histone H3 by cathepsin L.
Adams-Cioaba MA, Krupa JC, Xu C, Mort JS, Min J
Nat Commun. 2011 2:197. doi: 10.1038/ncomms1204
PMID: 21326229

Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2).
Xu C, Bian C, Yang W, Galka M, Ouyang H, Chen C, Qiu W, Liu H, Jones AE, MacKenzie F, Pan P, Li SS, Wang H, Min J
Proc. Natl. Acad. Sci. U.S.A.. 2010 107(45):19266-71. doi: 10.1073/pnas.1008937107
PMID: 20974918

Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain.
Liu K, Chen C, Guo Y, Lam R, Bian C, Xu C, Zhao DY, Jin J, MacKenzie F, Pawson T, Min J
Proc. Natl. Acad. Sci. U.S.A.. 2010 107(43):18398-403. doi: 10.1073/pnas.1013106107
PMID: 20937909

L3MBTL1 recognition of mono- and dimethylated histones.
Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH
Nat. Struct. Mol. Biol.. 2007 14(12):1229-30. doi: 10.1038/nsmb1340
PMID: 18026117

Structural basis for molecular recognition and presentation of histone H3 by WDR5.
Schuetz A, Allali-Hassani A, Martín F, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Arrowsmith CH, Min J
EMBO J.. 2006 25(18):4245-52. doi: 10.1038/sj.emboj.7601316
PMID: 16946699

2017

Peptide recognition by HP1 chromoshadow domains revisited: plasticity in the pseudosymmetric histone binding site of human HP1.
Liu Y, Qin S, Lei M, Tempel W, Zhang Y, Loppnau P, Li Y, Min J
J. Biol. Chem.. 21.02.2017 . doi: 10.1074/jbc.M116.768374
PMID: 28223359

2016

Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly.
Xu C, Ishikawa H, Izumikawa K, Li L, He H, Nobe Y, Yamauchi Y, Shahjee HM, Wu XH, Yu YT, Isobe T, Takahashi N, Min J
Genes Dev.. 01.11.2016 30(21):2376-2390. doi: 10.1101/gad.288340.116
PMID: 27881600

Structural biology: HDAC6 finally crystal clear.
Liu Y, Li L, Min J
Nat. Chem. Biol.. 18.08.2016 12(9):660-1. doi: 10.1038/nchembio.2158
PMID: 27538024

Structural basis of arginine asymmetrical dimethylation by PRMT6.
Wu H, Zheng W, Eram MS, Vhuiyan M, Dong A, Zeng H, He H, Brown P, Frankel A, Vedadi M, Luo M, Min J
Biochem. J.. 01.08.2016 . doi: 10.1042/BCJ20160537
PMID: 27480107

Structure and function of histone methylation-binding proteins in plants.
Liu Y, Min J
Biochem. J.. 15.06.2016 473(12):1663-80. doi: 10.1042/BCJ20160123
PMID: 27288029

PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3.
Chung HR, Xu C, Fuchs A, Mund A, Lange M, Staege H, Schubert T, Bian C, Dunkel I, Eberharter A, Regnard C, Klinker H, Meierhofer D, Cozzuto L, Winterpacht A, DiCroce L, Min J, Will H, Kinkley S
Elife. 25.05.2016 5:. doi: 10.7554/eLife.10607
PMID: 27223324

Family-wide characterization of histone binding abilities of human CW domain containing proteins.
Liu Y, Tempel W, Zhang Q, Liang X, Loppnau P, Qin S, Min J
J. Biol. Chem.. 01.03.2016 . doi: 10.1074/jbc.M116.718973
PMID: 26933034

Structural Basis for Substrate Preference of SMYD3, A SET Domain-containing Protein Lysine Methyltransferase.
Fu W, Liu N, Qiao Q, Wang M, Min J, Zhu B, Xu RM, Yang N
J. Biol. Chem.. 29.02.2016 . doi: 10.1074/jbc.M115.709832
PMID: 26929412

A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1.
Stuckey JI, Dickson BM, Cheng N, Liu Y, Norris JL, Cholensky SH, Tempel W, Qin S, Huber KG, Sagum C, Black K, Li F, Huang XP, Roth BL, Baughman BM, Senisterra G, Pattenden SG, Vedadi M, Brown PJ, Bedford MT, Min J, Arrowsmith CH, James LI, Frye SV
Nat. Chem. Biol.. 25.01.2016 . doi: 10.1038/nchembio.2007
PMID: 26807715

2015

SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination.
Yanling Zhao D, Gish G, Braunschweig U, Li Y, Ni Z, Schmitges FW, Zhong G, Liu K, Li W, Moffat J, Vedadi M, Min J, Pawson TJ, Blencowe BJ, Greenblatt JF
Nature. 23.12.2015 . doi: 10.1038/nature16469
PMID: 26700805

Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins.
Kamps JJ, Huang J, Poater J, Xu C, Pieters BJ, Dong A, Min J, Sherman W, Beuming T, Matthias Bickelhaupt F, Li H, Mecinović J
Nat Commun. 19.11.2015 6:8911. doi: 10.1038/ncomms9911
PMID: 26578293

Structural basis for substrate recognition by the human N-terminal methyltransferase 1.
Dong C, Mao Y, Tempel W, Qin S, Li L, Loppnau P, Huang R, Min J
Genes Dev.. 05.11.2015 . doi: 10.1101/gad.270611.115
PMID: 26543161

Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP.
Liu Y, Lau J, Li W, Tempel W, Li L, Dong A, Narula A, Qin S, Min J
Biochem. J.. 02.11.2015 . doi: 10.1042/BJ20150830
PMID: 26527736

Crystal structure of human nuclear pore complex component NUP43.
Xu C, Li Z, He H, Wernimont A, Li Y, Loppnau P, Min J
FEBS Lett.. 19.09.2015 . doi: 10.1016/j.febslet.2015.09.008
PMID: 26391640

Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome.
Wu H, Zeng H, Lam R, Tempel W, Kerr ID, Min J
Acta Crystallogr F Struct Biol Commun. 01.08.2015 71(Pt 8):981-5. doi: 10.1107/S2053230X15010183
PMID: 26249686

Ankyrin Repeats of ANKRA2 Recognize a PxLPxL Motif on the 3M Syndrome Protein CCDC8.
Nie J, Xu C, Jin J, Aka JA, Tempel W, Nguyen V, You L, Weist R, Min J, Pawson T, Yang XJ
Structure. 26.02.2015 . doi: 10.1016/j.str.2015.02.001
PMID: 25752541

2014

Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation.
Dong C, Zhang H, Xu C, Arrowsmith CH, Min J
IUCrJ. 01.11.2014 1(Pt 6):540-549. doi: 10.1107/S2052252514020922
PMID: 25485134

Structural basis for selective binding of m(6)A RNA by the YTHDC1 YTH domain.
Xu C, Wang X, Liu K, Roundtree IA, Tempel W, Li Y, Lu Z, He C, Min J
Nat. Chem. Biol.. 21.09.2014 . doi: 10.1038/nchembio.1654
PMID: 25242552

RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.
Ni Z, Xu C, Guo X, Hunter GO, Kuznetsova OV, Tempel W, Marcon E, Zhong G, Guo H, Kuo WH, Li J, Young P, Olsen JB, Wan C, Loppnau P, El Bakkouri M, Senisterra GA, He H, Huang H, Sidhu SS, Emili A, Murphy S, Mosley AL, Arrowsmith CH, Min J, Greenblatt JF
Nat. Struct. Mol. Biol.. 06.07.2014 . doi: 10.1038/nsmb.2853
PMID: 24997600

Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1.
Qin S, Liu Y, Tempel W, Eram MS, Bian C, Liu K, Senisterra G, Crombet L, Vedadi M, Min J
Nat Commun. 24.05.2014 5:3952. doi: 10.1038/ncomms4952
PMID: 24853335

A Chromatin-Dependent Role of the Fragile X Mental Retardation Protein FMRP in the DNA Damage Response.
Alpatov R, Lesch BJ, Nakamoto-Kinoshita M, Blanco A, Chen S, Stützer A, Armache KJ, Simon MD, Xu C, Ali M, Murn J, Prisic S, Kutateladze TG, Vakoc CR, Min J, Kingston RE, Fischle W, Warren ST, Page DC, Shi Y
Cell. 08.05.2014 157(4):869-81. doi: 10.1016/j.cell.2014.03.040
PMID: 24813610

Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single stranded m6A RNA demethylation.
Xu C, Liu K, Tempel W, Demetriades M, Aik W, Schofield CJ, Min J
J. Biol. Chem.. 28.04.2014 . doi: 10.1074/jbc.M114.550350
PMID: 24778178

Epigenetic targets and drug discovery: Part 1: Histone methylation.
Liu Y, Liu K, Qin S, Xu C, Min J
Pharmacol. Ther.. 02.04.2014 . doi: 10.1016/j.pharmthera.2014.03.007
PMID: 24704322

2013

Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2.
Wu H, Siarheyeva A, Zeng H, Lam R, Dong A, Wu XH, Li Y, Schapira M, Vedadi M, Min J
FEBS Lett.. 29.11.2013 587(23):3859-68. doi: 10.1016/j.febslet.2013.10.020
PMID: 24396869

Biochemical and Structural Studies of Conserved Maf Proteins Revealed Nucleotide Pyrophosphatases with a Preference for Modified Nucleotides.
Tchigvintsev A, Tchigvintsev D, Flick R, Popovic A, Dong A, Xu X, Brown G, Lu W, Wu H, Cui H, Dombrowski L, Joo JC, Beloglazova N, Min J, Savchenko A, Caudy AA, Rabinowitz JD, Murzin AG, Yakunin AF
Chem. Biol.. 22.10.2013 . doi: 10.1016/j.chembiol.2013.09.011
PMID: 24210219

Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation.
Islam K, Chen Y, Wu H, Bothwell IR, Blum GJ, Zeng H, Dong A, Zheng W, Min J, Deng H, Luo M
Proc. Natl. Acad. Sci. U.S.A.. 30.09.2013 . doi: 10.1073/pnas.1216365110
PMID: 24082136

2012

Crystal Structure of the Human SUV39H1 Chromodomain and Its Recognition of Histone H3K9me2/3.
Wang T, Xu C, Liu Y, Fan K, Li Z, Sun X, Ouyang H, Zhang X, Zhang J, Li Y, Mackenzie F, Min J, Tu X
PLoS ONE. 28.12.2012 7(12):e52977. doi: 10.1371/journal.pone.0052977
PMID: 23285239

Tudor domains of the PRC2 components PHF1 and PHF19 selectively bind to histone H3K36me3.
Qin S, Guo Y, Xu C, Bian C, Fu M, Gong S, Min J
Biochem. Biophys. Res. Commun.. 07.12.2012 . doi: 10.1016/j.bbrc.2012.11.116
PMID: 23228662

Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development.
Xu Y, Xu C, Kato A, Tempel W, Abreu JG, Bian C, Hu Y, Hu D, Zhao B, Cerovina T, Diao J, Wu F, He HH, Cui Q, Clark E, Ma C, Barbara A, Veenstra GJ, Xu G, Kaiser UB, Liu XS, Sugrue SP, He X, Min J, Kato Y, Shi YG
Cell. 07.12.2012 151(6):1200-13. doi: 10.1016/j.cell.2012.11.014
PMID: 23217707

Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2.
Zheng W, Ibáñez G, Wu H, Blum G, Zeng H, Dong A, Li F, Hajian T, Allali-Hassani A, Amaya MF, Siarheyeva A, Yu W, Brown PJ, Schapira M, Vedadi M, Min J, Luo M
J. Am. Chem. Soc.. 31.10.2012 134(43):18004-14. doi: 10.1021/ja307060p
PMID: 23043551

An allosteric inhibitor of protein arginine methyltransferase 3.
Siarheyeva A, Senisterra G, Allali-Hassani A, Dong A, Dobrovetsky E, Wasney GA, Chau I, Marcellus R, Hajian T, Liu F, Korboukh I, Smil D, Bolshan Y, Min J, Wu H, Zeng H, Loppnau P, Poda G, Griffin C, Aman A, Brown PJ, Jin J, Al-Awar R, Arrowsmith CH, Schapira M, Vedadi M
Structure. 08.08.2012 20(8):1425-35. doi: 10.1016/j.str.2012.06.001
PMID: 22795084

Structural basis for substrate specificity and catalysis of human histone acetyltransferase 1.
Wu H, Moshkina N, Min J, Zeng H, Joshua J, Zhou MM, Plotnikov AN
Proc. Natl. Acad. Sci. U.S.A.. 05.06.2012 109(23):8925-30. doi: 10.1073/pnas.1114117109
PMID: 22615379

Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock.
Xu C, Jin J, Bian C, Lam R, Tian R, Weist R, You L, Nie J, Bochkarev A, Tempel W, Tan CS, Wasney GA, Vedadi M, Gish GD, Arrowsmith CH, Pawson T, Yang XJ, Min J
Sci Signal. 29.05.2012 5(226):ra39. doi: 10.1126/scisignal.2002979
PMID: 22649097

Structural basis of the chromodomain of Cbx3 bound to methylated peptides from histone h1 and G9a.
Ruan J, Ouyang H, Amaya MF, Ravichandran M, Loppnau P, Min J, Zang J
PLoS ONE. 13.04.2012 7(4):e35376. doi: 10.1371/journal.pone.0035376
PMID: 22514736

Crystal structures of the Tudor domains of human PHF20 reveal novel structural variations on the Royal Family of proteins.
Adams-Cioaba MA, Li Z, Tempel W, Guo Y, Bian C, Li Y, Lam R, Min J
FEBS Lett.. 23.03.2012 586(6):859-65. doi: 10.1016/j.febslet.2012.02.012
PMID: 22449972

Crystal structures from the Plasmodium peroxiredoxins: new insights into oligomerization and product binding.
Qiu W, Dong A, Pizarro JC, Botchkarsev A, Min J, Wernimont AK, Hills T, Hui R, Artz JD
BMC Struct. Biol.. 19.03.2012 12:2. doi: 10.1186/1472-6807-12-2
PMID: 22429898

Crystal structure of TDRD3 and methyl-arginine binding characterization of TDRD3, SMN and SPF30.
Liu K, Guo Y, Liu H, Bian C, Lam R, Liu Y, Mackenzie F, Rojas LA, Reinberg D, Bedford MT, Xu RM, Min J
PLoS ONE. 17.02.2012 7(2):e30375. doi: 10.1371/journal.pone.0030375
PMID: 22363433

Crystal structures of the coil 2B fragment and the globular tail domain of human lamin B1.
Ruan J, Xu C, Bian C, Lam R, Wang JP, Kania J, Min J, Zang J
FEBS Lett.. 17.02.2012 586(4):314-8. doi: 10.1016/j.febslet.2012.01.007
PMID: 22265972

2011

Structural basis for specific binding of human MPP8 chromodomain to histone H3 methylated at lysine 9.
Li J, Li Z, Ruan J, Xu C, Tong Y, Pan PW, Tempel W, Crombet L, Min J, Zang J
PLoS ONE. 12.10.2011 6(10):e25104. doi: 10.1371/journal.pone.0025104
PMID: 22022377

Crystal structure of the Cys2His2-type zinc finger domain of human DPF2.
Zhang W, Xu C, Bian C, Tempel W, Crombet L, MacKenzie F, Min J, Liu Z, Qi C
Biochem. Biophys. Res. Commun.. 16.09.2011 413(1):58-61. doi: 10.1016/j.bbrc.2011.08.043
PMID: 21888896

Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation.
Bian C, Xu C, Ruan J, Lee KK, Burke TL, Tempel W, Barsyte D, Li J, Wu M, Zhou BO, Fleharty BE, Paulson A, Allali-Hassani A, Zhou JQ, Mer G, Grant PA, Workman JL, Zang J, Min J
EMBO J.. 20.07.2011 30(14):2829-42. doi: 10.1038/emboj.2011.193
PMID: 21685874

PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming.
Zhang Z, Jones A, Sun CW, Li C, Chang CW, Joo HY, Dai Q, Mysliwiec MR, Wu LC, Guo Y, Yang W, Liu K, Pawlik KM, Erdjument-Bromage H, Tempst P, Lee Y, Min J, Townes TM, Wang H
Stem Cells. 07.07.2011 29(2):229-40. doi: 10.1002/stem.578
PMID: 21732481

Composition, recruitment and regulation of the PRC2 complex.
Nayak V, Xu C, Min J
Nucleus. 01.07.2011 2(4):277-82. doi: 10.4161/nucl.2.4.16266
PMID: 21941108

Structural and histone binding ability characterizations of human PWWP domains.
Wu H, Zeng H, Lam R, Tempel W, Amaya MF, Xu C, Dombrovski L, Qiu W, Wang Y, Min J
PLoS ONE. 20.06.2011 6(6):e18919. doi: 10.1371/journal.pone.0018919
PMID: 21720545

Structure and function of WD40 domain proteins.
Xu C, Min J
Protein Cell. 06.04.2011 2(3):202-14. doi: 10.1007/s13238-011-1018-1
PMID: 21468892

Structural basis for the recognition and cleavage of histone H3 by cathepsin L.
Adams-Cioaba MA, Krupa JC, Xu C, Mort JS, Min J
Nat Commun. 18.02.2011 2:197. doi: 10.1038/ncomms1204
PMID: 21326229

Recognition and specificity determinants of the human cbx chromodomains.
Kaustov L, Ouyang H, Amaya M, Lemak A, Nady N, Duan S, Wasney GA, Li Z, Vedadi M, Schapira M, Min J, Arrowsmith CH
J. Biol. Chem.. 07.01.2011 286(1):521-9. doi: 10.1074/jbc.M110.191411
PMID: 21047797

2010

Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2).
Xu C, Bian C, Yang W, Galka M, Ouyang H, Chen C, Qiu W, Liu H, Jones AE, MacKenzie F, Pan P, Li SS, Wang H, Min J
Proc. Natl. Acad. Sci. U.S.A.. 09.11.2010 107(45):19266-71. doi: 10.1073/pnas.1008937107
PMID: 20974918

Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2.
Adams-Cioaba MA, Guo Y, Bian C, Amaya MF, Lam R, Wasney GA, Vedadi M, Xu C, Min J
PLoS ONE. 02.11.2010 5(11):e13559. doi: 10.1371/journal.pone.0013559
PMID: 21072162

Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain.
Liu K, Chen C, Guo Y, Lam R, Bian C, Xu C, Zhao DY, Jin J, MacKenzie F, Pawson T, Min J
Proc. Natl. Acad. Sci. U.S.A.. 26.10.2010 107(43):18398-403. doi: 10.1073/pnas.1013106107
PMID: 20937909

Structural genomics of histone tail recognition.
Wang M, Mok MW, Harper H, Lee WH, Min J, Knapp S, Oppermann U, Marsden B, Schapira M
Bioinformatics. 15.10.2010 26(20):2629-30. doi: 10.1093/bioinformatics/btq491
PMID: 20739309

MOF and H4 K16 acetylation play important roles in DNA damage repair by modulating recruitment of DNA damage repair protein Mdc1.
Li X, Corsa CA, Pan PW, Wu L, Ferguson D, Yu X, Min J, Dou Y
Mol. Cell. Biol.. 13.09.2010 30(22):5335-47. doi: 10.1128/MCB.00350-10
PMID: 20837706

Structural biology of human H3K9 methyltransferases.
Wu H, Min J, Lunin VV, Antoshenko T, Dombrovski L, Zeng H, Allali-Hassani A, Campagna-Slater V, Vedadi M, Arrowsmith CH, Plotnikov AN, Schapira M
PLoS ONE. 11.01.2010 5(1):e8570. doi: 10.1371/journal.pone.0008570
PMID: 20084102

2009

Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi.
Chen C, Jin J, James DA, Adams-Cioaba MA, Park JG, Guo Y, Tenaglia E, Xu C, Gish G, Min J, Pawson T
Proc. Natl. Acad. Sci. U.S.A.. 01.12.2009 106(48):20336-41. doi: 10.1073/pnas.0911640106
PMID: 19918066

Structural studies of a four-MBT repeat protein MBTD1.
Eryilmaz J, Pan P, Amaya MF, Allali-Hassani A, Dong A, Adams-Cioaba MA, Mackenzie F, Vedadi M, Min J
PLoS ONE. 20.10.2009 4(10):e7274. doi: 10.1371/journal.pone.0007274
PMID: 19841675

Crystal structures of human CDY proteins reveal a crotonase-like fold.
Wu H, Min J, Antoshenko T, Plotnikov AN
Proteins. 10.06.2009 76(4):1054-61. doi: 10.1002/prot.22472
PMID: 19507244

Structure and function of histone methylation binding proteins.
Adams-Cioaba MA, Min J
Biochem. Cell Biol.. 24.02.2009 87(1):93-105. doi: 10.1139/O08-129
PMID: 19234526

Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2.
Guo Y, Nady N, Qi C, Allali-Hassani A, Zhu H, Pan P, Adams-Cioaba MA, Amaya MF, Dong A, Vedadi M, Schapira M, Read RJ, Arrowsmith CH, Min J
Nucleic Acids Res.. 20.02.2009 37(7):2204-10. doi: 10.1093/nar/gkp086
PMID: 19233876

2008

Structural and kinetic differences between human and Aspergillus fumigatus D-glucosamine-6-phosphate N-acetyltransferase.
Hurtado-Guerrero R, Raimi OG, Min J, Zeng H, Vallius L, Shepherd S, Ibrahim AF, Wu H, Plotnikov AN, van Aalten DM
Biochem. J.. 15.10.2008 415(2):217-23. doi: 10.1042/BJ20081000
PMID: 18601654

Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism.
Wu H, Min J, Zeng H, McCloskey DE, Ikeguchi Y, Loppnau P, Michael AJ, Pegg AE, Plotnikov AN
J. Biol. Chem.. 06.06.2008 283(23):16135-46. doi: 10.1074/jbc.M710323200
PMID: 18367445

A SPOT on the chromatin landscape? Histone peptide arrays as a tool for epigenetic research.
Nady N, Min J, Kareta MS, Chédin F, Arrowsmith CH
Trends Biochem. Sci.. 04.06.2008 33(7):305-13. doi: 10.1016/j.tibs.2008.04.014
PMID: 18538573

Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.
Schuetz A, Min J, Allali-Hassani A, Schapira M, Shuen M, Loppnau P, Mazitschek R, Kwiatkowski NP, Lewis TA, Maglathin RL, McLean TH, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH
J. Biol. Chem.. 25.04.2008 283(17):11355-63. doi: 10.1074/jbc.M707362200
PMID: 18285338

Crystal structure of the methyltransferase domain of human TARBP1.
Wu H, Min J, Zeng H, Plotnikov AN
Proteins. 17.04.2008 72(1):519-25. doi: 10.1002/prot.22065
PMID: 18412263

2007

L3MBTL1 recognition of mono- and dimethylated histones.
Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH
Nat. Struct. Mol. Biol.. 18.11.2007 14(12):1229-30. doi: 10.1038/nsmb1340
PMID: 18026117

In situ proteolysis for protein crystallization and structure determination.
Dong A, Xu X, Edwards AM, Chang C, Chruszcz M, Cuff M, Cymborowski M, Di Leo R, Egorova O, Evdokimova E, Filippova E, Gu J, Guthrie J, Ignatchenko A, Joachimiak A, Klostermann N, Kim Y, Korniyenko Y, Minor W, Que Q, Savchenko A, Skarina T, Tan K, Yakunin A, Yee A, Yim V, Zhang R, Zheng H, Akutsu M, Arrowsmith C, Avvakumov GV, Bochkarev A, Dahlgren LG, Dhe-Paganon S, Dimov S, Dombrovski L, Finerty P, Flodin S, Flores A, Gräslund S, Hammerström M, Herman MD, Hong BS, Hui R, Johansson I, Liu Y, Nilsson M, Nedyalkova L, Nordlund P, Nyman T, Min J, Ouyang H, Park HW, Qi C, Rabeh W, Shen L, Shen Y, Sukumard D, Tempel W, Tong Y, Tresagues L, Vedadi M, Walker JR, Weigelt J, Welin M, Wu H, Xiao T, Zeng H, Zhu H
Nat. Methods. 04.11.2007 4(12):1019-21. doi: 10.1038/nmeth1118
PMID: 17982461

Structure and mechanism of spermidine synthases.
Wu H, Min J, Ikeguchi Y, Zeng H, Dong A, Loppnau P, Pegg AE, Plotnikov AN
Biochemistry. 17.07.2007 46(28):8331-9. doi: 10.1021/bi602498k
PMID: 17585781

Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin.
Schuetz A, Min J, Antoshenko T, Wang CL, Allali-Hassani A, Dong A, Loppnau P, Vedadi M, Bochkarev A, Sternglanz R, Plotnikov AN
Structure. 16.03.2007 15(3):377-89. doi: 10.1016/j.str.2007.02.002
PMID: 17355872

2006

Structural basis for molecular recognition and presentation of histone H3 by WDR5.
Schuetz A, Allali-Hassani A, Martín F, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Arrowsmith CH, Min J
EMBO J.. 20.09.2006 25(18):4245-52. doi: 10.1038/sj.emboj.7601316
PMID: 16946699

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