Since 2004, Ray’s group has become the world leader in the expression, purification, crystallization and chemical screening of parasite proteins. The goal of this research is to produce tools to support anti-parasitic drug discovery as well as to enable other parasitologists in their quest to understand parasite biology and host invasion. The tools produced by Ray’s team include purified recombinant parasite proteins, inhibitors of these proteins and their crystallographic structures, all of which are readily shared with parasitology labs around the world.
Malaria, toxoplasmosis, cryptosporidiosis, Chagas disease, African Sleeping Disease and visceral leishmaniasis are diseases resulting from infection by protozoan parasites. For some of these diseases, such as malaria, existing drugs face the threat of resistance. For others, such as cryptosporidiosis, there is no effective chemotherapy. At SGC in Toronto, Raymond Hui leads the Structural and Chemical Parasitology group to study proteins of protozoan parasites. Structural parasitology is the study of structures of parasite proteins. Chemical parasitology involves the identification and use of chemical probes to investigate the functions of these proteins.