Yufeng got his Ph.D. in Molecular Biology and Biochemistry from the Institute of Biophysics, Chinese Academy of Sciences. He worked as a postdoc at the Case Western Reserve University (Cleveland, Ohio, USA) on the structure and function of the plexin family of GTPase activating proteins and cell signaling before he joined SGC in 2006. Yufeng is currently an Assistant Professor in the Department of Pharmacology and Toxicology at the University of Toronto and is leading the Ubiquitin Biology and Cell Signalling programs at SGC Toronto. He teaches graduate course PSL1053H: "Advanced Topics: Critical Assessment of Ion Channel Function" and lab project course PCL472Y/474Y. His research focuses on the functional role of ubiquitination in stress response and gene regulation, development of small molecule as well as macromoleculr inhibitors of ubiquitin-related enzymes. Currently, he holds an NSERC Discovery Grant, a Neuroscience Catalyst grant, and is the co-PI on a CIHR Project Grant. He is an Editorial Board member of Scientific Reports. Full list of publication is available from Google Scholar.
The Ubiquitin Biology group at the SGC Toronto focuses on understanding the structure, function, specificity, and enzymatic mechanism of E3 ubiquitin ligases and deubiquitinases(DUBs), including key enzymes involved in histone (de-)ubiquitylation and sumoylation. Particularly we are interested in the function and activity regulation of ubiquitin E3 ligases, and ubiquitin-specific proteases. These families of proteins have been directly implicated in many human diseases like autism, cancer diabetes, leukemia, inflammation, and etc. We utilize the SGC's established high-throughput structural biology (HTSB) platform for protein production, structure determination, and various enzymological and biophysical techniques, including but not limited to ITC, SPR, BLI, SAXS, to investigate the function of these enzymes. The HTSB platform in SGC provides access to high capacity prokaryotic and eukaryotic expression systems, state-of-the-art protein purification and crystallography facilities, and is supported by core service groups including biotech, crystallography, and biophysics. We also collaborate with internal and external groups to identify small molecule compounds and macromolecular inhibitors that will alter the activity of disease-related ligases and proteases.