Publications

Ouyang H, Ali YO, Ravichandran M, Dong A, Qiu W, Mackenzie F, Dhe-Paganon S, Arrowsmith CH, Zhai RG. Protein aggregates are recruited to the aggresome by histone deacetylase 6 via unanchored ubiquitin C-termini. J Biol Chem. 287(4):2317-27. (2012)

Egger S, Chaikuad A, Klimacek M, Kavanagh KL, Oppermann U, Nidetzky B. Structural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme Intermediates. J Biol Chem. 287(3):2119-29. (2012)

Huber K, Brault L, Fedorov O, Gasser C, Filippakopoulos P, Bullock AN, Fabbro D, Trappe J, Schwaller J, Knapp S, Bracher F. 7,8-Dichloro-1-oxo-?-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes. J Med Chem. 55(1):403-13. (2012)

Shrestha A, Hamilton G, O'Neill E, Knapp S, Elkins JM. Analysis of conditions affecting auto-phosphorylation of human kinases during expression in bacteria. Protein Expr Purif. 81(1):136-43. (2012)

Fedorov O, Niesen FH, Knapp S. Kinase inhibitor selectivity profiling using differential scanning fluorimetry. Methods Mol Biol. 795:109-18. (2012)

Pacheco B, Crombet L, Loppnau P, Cossar D. A screening strategy for heterologous protein expression in Escherichia coli with the highest return of investment. Protein Expr Purif. 81(1):33-41. (2012)

Allali-Hassani A, Wasney GA, Siarheyeva A, Hajian T, Arrowsmith CH, Vedadi M. Fluorescence-Based Methods for Screening Writers and Readers of Histone Methyl Marks. J Biomol Screen. 17(1):71-84. (2012)

Chaikuad A, Froese DS, Berridge G, von Delft F, Oppermann U, Yue WW. Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis. Proc Natl Acad Sci U S A. 108(52):21028-33. (2011)

Siddiqui N, Tempel W, Nedyalkova L, Volpon L, Wernimont AK, Osborne MJ, Park HW, Borden KL. Structural Insights into the Allosteric Effects of 4EBP1 on the Eukaryotic Translation Initiation Factor eIF4E. J Mol Biol. Epub ahead of print (2011)

Hillringhaus L, Yue WW, Rose NR, Ng SS, Gileadi C, Loenarz C, Bello SH, Bray JE, Schofield CJ, Oppermann U. Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family. J Biol Chem. 286(48):41616-25. (2011)

Santiago C, Nguyen K, Schapira M. Druggability of methyl-lysine binding sites. J Comput Aided Mol Des. 25(12):1171-8. (2011)

Senisterra G, Chau I, Vedadi M. Thermal Denaturation Assays in Chemical Biology. Assay Drug Dev Technol. Epub ahead of print (2011)

Filippakopoulos P, Picaud S, Fedorov O, Keller M, Wrobel M, Morgenstern O, Bracher F, Knapp S. Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family. Bioorg Med Chem. Epub ahead of print (2011)

Weyand S, Shimamura T, Yajima S, Suzuki S, Mirza O, Krusong K, Carpenter EP, Rutherford NG, Hadden JM, O'Reilly J, Ma P, Saidijam M, Patching SG, Hope RJ, Norbertczak HT, Roach PC, Iwata S, Henderson PJ, Cameron AD. Structure and molecular mechanism of a nucleobase-cation-symport-1 family transporter. Science. 322(5902):709-13. (2011)

Kryshtafovych A, Moult J, Bartual SG, Bazan JF, Berman H, Casteel DE, Christodoulou E, Everett JK, Hausmann J, Heidebrecht T, Hills T, Hui R, Hunt JF, Seetharaman J, Joachimiak A, Kennedy MA, Kim C, Lingel A, Michalska K, Montelione GT, Otero JM, Perrakis A, Pizarro JC, van Raaij MJ, Ramelot TA, Rousseau F, Tong L, Wernimont AK, Young J, Schwede T. Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction. Proteins. 79 Suppl 10:6-20. do (2011)

Keates T, Cooper CD, Savitsky P, Allerston CK, Phillips C, Hammarstr�m M, Daga N, Berridge G, Mahajan P, Burgess-Brown NA, M�ller S, Gr�slund S, Gileadi O. Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation. N Biotechnol. Epub ahead of print (2011)

Hewings DS, Wang M, Philpott M, Fedorov O, Uttarkar S, Filippakopoulos P, Picaud S, Vuppusetty C, Marsden B, Knapp S, Conway SJ, Heightman TD. 3,5-Dimethylisoxazoles Act As Acetyl-lysine-mimetic Bromodomain Ligands. J Med Chem. 54(19):6761-70. (2011)

Philpott M, Yang J, Tumber T, Fedorov O, Uttarkar S, Filippakopoulos P, Picaud S, Keates T, Felletar I, Ciulli A, Knapp S, Heightman TD. Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery. Mol Biosyst. 7(10):2899-908. (2011)

Artz JD, Wernimont AK, Allali-Hassani A, Zhao Y, Amani M, Lin YH, Senisterra G, Wasney GA, Fedorov O, King O, Roos A, Lunin VV, Qiu W, Finerty P Jr, Hutchinson A, Chau I, von Delft F, Mackenzie F, Lew J, Kozieradzki I, Vedadi M, Schapira M, Zhang C, Shokat K, Heightman T, Hui R. The Cryptosporidium parvum Kinome. BMC Genomics. 12(1):478. (2011)

Qiu L, Dhe-Paganon S. Oligomeric structure of the MALT1 tandem Ig-like domains. PLoS One. 6(9):e23220. (2011)

Zhang W, Xu C, Bian C, Tempel W, Crombet L, MacKenzie F, Min J, Liu Z, Qi C. Crystal structure of the Cys2His2-type zinc finger domain of human DPF2. Biochem Biophys Res Commun. 413(1):58-61. (2011)

Muller S, Filippakopoulos P, Knapp S. Bromodomains as therapeutic targets. Expert Rev Mol Med. 13:e29. (2011)

Liu F, Barsyte-Lovejoy D, Allali-Hassani A, He Y, Herold JM, Chen X, Yates CM, Frye SV, Brown PJ, Huang J, Vedadi M, Arrowsmith CH, Jin J. Optimization of Cellular Activity of G9a Inhibitors 7-Aminoalkoxy-quinazolines. J Med Chem. 54(17):6139-50. (2011)

Schapira M. Structural Chemistry of Human SET Domain Protein Methyltransferases. Curr Chem Genomics. 5(Suppl 1):85-94. (2011)

Heightman TD. Chemical biology of lysine demethylases. Curr Chem Genomics. 5(Suppl 1):62-71. (2011)

Lemak A, Yee A, Bezsonova I, Dhe-Paganon S, Arrowsmith CH. Zn-binding AZUL domain of human ubiquitin protein ligase Ube3A. J Biomol NMR 51(1-2):185-90. (2011)

Nayak V, Xu C, Min J. Composition, recruitment and regulation of the PRC2 complex. Nucleus. 2(4). (2011)

Wang AT, Sengerov� B, Cattell E, Inagawa T, Hartley JM, Kiakos K, Burgess-Brown NA, Swift LP, Enzlin JH, Schofield CJ, Gileadi O, Hartley JA, McHugh PJ. Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair. Genes Dev. 25(17):1859-70. (2011)

Wallach I, Jaitly N, Nguyen K, Schapira M, Lilien R. Normalizing Molecular Docking Rankings using Virtually Generated Decoys. J Chem Inf Model. 51(8):1817-30. (2011)

Vedadi M, Barsyte-Lovejoy D, Liu F, Rival-Gervier S, Allali-Hassani A, Labrie V, Wigle TJ, Dimaggio PA, Wasney GA, Siarheyeva A, Dong A, Tempel W, Wang SC, Chen X, Chau I, Mangano TJ, Huang XP, Simpson CD, Pattenden SG, Norris JL, Kireev DB, Tripathy A, Edwards A, Roth BL, Janzen WP, Garcia BA, Petronis A, Ellis J, Brown PJ, Frye SV, Arrowsmith CH, Jin J. A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol. 7(9):648. (2011)

Brokx SJ, Wernimont AK, Dong A, Wasney GA, Lin YH, Lew J, Vedadi M, Lee WH, Hui R. Characterization of 14-3-3 Proteins from Cryptosporidium parvum. PLoS One. 6(8):e14827. (2011)

Miduturu CV, Deng X, Kwiatkowski N, Yang W, Brault L, Filippakopoulos P, Chung E, Yang Q, Schwaller J, Knapp S, King RW, Lee JD, Herrgard S, Zarrinkar P, Gray NS. High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Chem Biol. 18(7):868-79. (2011)

Deligianni E, Morgan RN, Bertuccini L, Kooij TW, Laforge A, Nahar C, Poulakakis N, Sch�ler H, Louis C, Matuschewski K, Siden-Kiamos I. Critical role for a stage-specific actin in male exflagellation of the malaria parasite. Cell Microbiol. Epub ahead of print (2011)

Wang H, Hota PK, Tong Y, Li B, Shen L, Nedyalkova L, Borthakur S, Kim S, Tempel W, Buck M, Park HW. Structural basis of Rnd1 binding to plexin Rho GTPase binding domains (RBDs). J Biol Chem. 286(29):26093-106. (2011)

Evans DM, Spencer CC, Pointon JJ, Su Z, Harvey D, Kochan G, Oppermann U, Dilthey A, Pirinen M, Stone MA, Appleton L, Moutsianas L, Leslie S, Wordsworth T, Kenna TJ, Karaderi T, Thomas GP, Ward MM, Weisman MH, Farrar C, Bradbury LA, Danoy P, Inman RD, Maksymowych W, Gladman D, Rahman P; Spondyloarthritis Research Consortium of Canada (SPARCC), Morgan A, Marzo-Ortega H, Bowness P, Gaffney K, Gaston JS, Smith M, Bruges-Armas J, Couto AR, Sorrentino R, Paladini F, Ferreira MA, Xu H, Liu Y, Jiang L, Lopez-Larrea C, D�az-Pe�a R, L�pez-V�zquez A, Zayats T, Band G, Bellenguez C, Blackburn H, Blackwell JM, Bramon E, Bumpstead SJ, Casas JP, Corvin A, Craddock N, Deloukas P, Dronov S, Duncanson A, Edkins S, Freeman C, Gillman M, Gray E, Gwilliam R, Hammond N, Hunt SE, Jankowski J, Jayakumar A, Langford C, Liddle J, Markus HS, Mathew CG, McCann OT, McCarthy MI, Palmer CN, Peltonen L, Plomin R, Potter SC, Rautanen A, Ravindrarajah R, Ricketts M, Samani N, Sawcer SJ, Strange A, Trembath RC, Viswanathan AC, Waller M, Weston P, Whittaker P, Widaa S, Wood NW, McVean G, Reveille JD, Wordsworth BP, Brown MA, Donnelly P; Australo-Anglo-American Spondyloarthritis Consortium (TASC); Wellcome Trust Case Control Consortium 2 (WTCCC2). Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet. 43(8):761-7. (2011)

Egger S, Chaikuad A, Kavanagh KL, Oppermann U, Nidetzky B. Structure and mechanism of human UDP-glucose 6-dehydrogenase. J Biol Chem. 286(27):23877-87. (2011)

Ebetino FH, Hogan AM, Sun S, Tsoumpra MK, Duan X, Triffitt JT, Kwaasi AA, Dunford JE, Barnett BL, Oppermann U, Lundy MW, Boyde A, Kashemirov BA, McKenna CE, Russell RG. The relationship between the chemistry and biological activity of the bisphosphonates. Bone. 49(1):20-33. (2011)

Thorsell AG, Lee WH, Persson C, Siponen MI, Nilsson M, Busam RD, Kotenyova T, Sch�ler H, Lehti� L. Comparative Structural Analysis of Lipid Binding START Domains. PLoS One. 6(6):e19521. (2011)

Soundararajan M, Eswaran J. Atypical Gtpasesas Drug Targets. Anticancer Agents Med Chem. Epub ahead of print (2011)

Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, Cox S, Xu S, Lopez-Girona A, Mercurio F, Wrana J, Durocher D, Meloche S, Webb DR, Tyers M, Sicheri F. An allosteric inhibitor of the human cdc34 ubiquitin-conjugating enzyme. Cell. 145(7):1075-87. (2011)

Luo X, Liu Y, Kubicek S, Myllyharju J, Tumber A, Ng S, Che KH, Podoll J, Heightman TD, Oppermann U, Schreiber SL, Wang X. A Selective Inhibitor and Probe of the Cellular Functions of Jumonji C Domain-Containing Histone Demethylases. J Am Chem Soc. 133(24):9451-6. (2011)

Strushkevich N, Mackenzie F, Cherkesova T, Grabovec I, Usanov S, Park HW. Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system. Proc Natl Acad Sci U S A. 108(25):10139-43. (2011)

Structural and Histone Binding Ability Characterizations of Human PWWP Domains. Structural and Histone Binding Ability Characterizations of Human PWWP Domains. PLoS One. 6(6):e18919. (2011)

Bian C, Xu C, Ruan J, Lee KK, Burke TL, Tempel W, Barsyte D, Li J, Wu M, Zhou BO, Fleharty BE, Paulson A, Allali-Hassani A, Zhou JQ, Mer G, Grant PA, Workman JL, Zang J, Min J. Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. EMBO J. Epub ahead of print (2011)

Hills T, Srivastava A, Ayi K, Wernimont AK, Kain K, Waters AP, Hui R, Pizarro JC. Characterization of a new phosphatase from Plasmodium. Mol Biochem Parasitol. Epub ahead of print (2011)

Lee WH, Yue WW, Raush E, Totrov M, Abagyan R, Oppermann U, Marsden BD. Interactive JIMD articles using the iSee concept: turning a new page on structural biology data. J Inherit Metab Dis. 34(3):565-7. (2011)

Picaud S, Kavanagh KL, Yue WW, Lee WH, Muller-Knapp S, Gileadi O, Sacchettini J, Oppermann U. Structural basis of fumarate hydratase deficiency. J Inherit Metab Dis. 34(3):671-6. (2011)

Yue WW, Oppermann U. High-throughput structural biology of metabolic enzymes and its impact on human diseases. J Inherit Metab Dis. 34(3):575-81. (2011)

Zhang Z, Kochan GT, Ng SS, Kavanagh KL, Oppermann U, Schofield CJ, McDonough MA. Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase. Biochem Biophys Res Commun. 408(4):553-8. (2011)

Colwill K; Renewable Protein Binder Working Group; In vitro Antibody Consortium, Persson H, Jarvik NE, Wyrzucki A, Wojcik J, Koide A, Kossiakoff AA, Koide S, Sidhu S, Dyson MR, Pershad K, Pavlovic JD, Karatt-Vellatt A, Schofield DJ, Kay BK, McCafferty J, Mersmann M, Meier D, Mersmann J, Helmsing S, Hust M, D�bel S; Monash Antibody Technologies Facility, Berkowicz S, Freemantle A, Spiegel M, Sawyer A, Layton D, Nice E; Pawson Laboratory, Dai A, Rocks O, Williton K, Fellouse FA, Hersi K, Pawson T; Human Protein Atlas, Nilsson P, Sundberg M, Sj�berg R, Sivertsson A, Schwenk JM, Takanen JO, Hober S, Uhl�n M; Structural Genomics Consortium, Dahlgren LG, Flores A, Johansson I, Weigelt J, Crombet L, Loppnau P, Kozieradzki I, Cossar D, Arrowsmith CH, Edwards AM, Gr�slund S. A roadmap to generate renewable protein binders to the human proteome. Nat Methods. 8(7):551-8. (2011)

Alenkin D, Yermekbayeva L, Mujib S, Vesterberg A, Newman E, Yamazaki K, Cossar D, Dhe-Paganon S. A centrifugation-free high-throughput protein purification system using in-line microfluidization. Protein Expr Purif. Epub ahead of print (2011)

Kochan G, Krojer T, Harvey D, Fischer R, Chen L, Vollmar M, von Delft F, Kavanagh KL, Brown MA, Bowness P, Wordsworth P, Kessler BM, Oppermann U. Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming. Proc Natl Acad Sci U S A. 108(19):7745-50 (2011)

Chang KH, King ON, Tumber A, Woon EC, Heightman TD, McDonough MA, Schofield CJ, Rose NR. Inhibition of histone demethylases by 4-carboxy-2,2'-bipyridyl compounds. ChemMedChem. 6(5):759-64. (2011)

Krojer T, von Delft F. Assessment of radiation damage behaviour in a large collection of empirically optimized datasets highlights the importance of unmeasured complicating effects. J Synchrotron Radiat. 18(Pt 3):387-97. (2011)

Feng L, Geisselbrecht Y, Blanck S, Wilbuer A, Atilla-Gokcumen GE, Filippakopoulos P, Kr�ling K, Celik MA, Harms K, Maksimoska J, Marmorstein R, Frenking G, Knapp S, Essen LO, Meggers E. Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors. J Am Chem Soc. 133(15):5976-86. (2011)

Chaikuad A, Shafqat N, Al-Mokhtar R, Cameron G, Clarke AR, Brady L, Oppermann U, Frayne J, Yue WW. Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, Biochem J. 435(2):401-9. (2011)

Chen D, Vollmar M, Rossi MN, Phillips C, Kraehenbuehl R, Slade D, Mehrotra PV, von Delft F, Crosthwaite SK, Gileadi O, Denu JM, Ahel I. Identification of Macro Domain Proteins as Novel O-Acetyl-ADP-Ribose Deacetylases. J Biol Chem. 286(15):13261-71. (2011)

Salah E, Ugochukwu E, Barr AJ, von Delft F, Knapp S, Elkins JM. Crystal Structures of ABL-Related Gene (ABL2) in Complex with Imatinib, Tozasertib (VX-680), and a Type I Inhibitor of the Triazole Carbothioamide Class. J Med Chem. 54(7):2359-67. (2011)

Nady N, Lemak A, Walker JR, Avvakumov GV, Kareta MS, Achour M, Xue S, Duan S, Allali-Hassani A, Zuo X, Wang YX, Bronner C, Chedin F, Arrowsmith CH, Dhe-Paganon S. Recognition of multivalent histone states associated with heterochromatin by UHRF1. J Biol Chem. Epub ahead of print (2011)

Herold JM, Wigle TJ, Norris JL, Lam R, Korboukh VK, Gao C, Ingerman LA, Kireev DB, Senisterra G, Vedadi M, Tripathy A, Brown PJ, Arrowsmith CH, Jin J, Janzen WP, Frye SV. Small-molecule ligands of methyl-lysine binding proteins. J Med Chem. 54(7):2504-11 (2011)

So AD, Gupta N, Brahmachari SK, Chopra I, Munos B, Nathan C, Outterson K, Paccaud JP, Payne DJ, Peeling RW, Spigelman M, Weigelt J. Towards new business models for R&D for novel antibiotics. Drug Resist Updat. 14(2):88-94. (2011)

Norman T, Edwards A, Bountra C, Friend S. The precompetitive space: time to move the yardsticks. Sci Transl Med. 3(76):76cm10 (2011)

Syeda F, Fagan RL, Wean M, Avvakumov GV, Walker JR, Xue S, Dhe-Paganon S, Brenner C. The Replication Focus Targeting Sequence (RFTS) Domain Is a DNA-competitive Inhibitor of Dnmt1. J Biol Chem. 286(17):15344-51 (2011)

Campagna-Slater V, Mok MW, Nguyen KT, Feher M, Najmanovich R, Schapira M. Structural Chemistry of the Histone Methyltransferases Cofactor Binding Site. J Chem Inf Model. 51(3):612-623. (2011)

Berridge G, Chalk R, D'Avanzo N, Dong L, Doyle D, Kim JI, Xia X, Burgess-Brown N, Deriso A, Carpenter EP, Gileadi O. High-performance liquid chromatography separation and intact mass analysis of detergent-solubilized integral membrane proteins. Anal Biochem. 410(2):272-80. (2011)

Kotzsch A, Vernet E, Hammarstr�m M, Berthelsen J, Weigelt J, Gr�slund S, Sundstr�m M. A secretory system for bacterial production of high-profile protein targets. Protein Sci. 20(3):597-609 (2011)

Fairman JW, Wijerathna SR, Ahmad MF, Xu H, Nakano R, Jha S, Prendergast J, Welin RM, Flodin S, Roos A, Nordlund P, Li Z, Walz T, Dealwis CG. Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat Struct Mol Biol 18(3):316-22. (2011)

Xu C, Bian C, Lam R, Dong A, Min J. The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain. Nat Commun. Epub ahead of print (2011)

Xu C, Min J. Structure and function of WD40 domain proteins. Protein Cell. 2(3):202-14. (2011)

Wernimont AK, Amani M, Qiu W, Pizarro JC, Artz JD, Lin YH, Lew J, Hutchinson A, Hui R. Structures of parasitic CDPK domains point to a common mechanism of activation. Proteins. 79(3):803-20. (2011)

Turgeon Z, J�rgensen R, Visschedyk D, Edwards PR, Legree S, McGregor C, Fieldhouse RJ, Mangroo D, Schapira M, Merrill AR. Newly Discovered and Characterized Antivirulence Compounds inhibit Bacterial Mono-ADP-ribosyltransferase Toxins. Antimicrob Agents Chemother. 55(3):983-91 (2011)

Lucic B, Zhang Y, King O, Mendoza-Maldonado R, Berti M, Niesen FH, Burgess-Brown NA, Pike AC, Cooper CD, Gileadi O, Vindigni A. A prominent {beta}-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation. Nucleic Acids Res. 39(5):1703-17. (2011)

Yap DB, Chu J, Berg T, Schapira M, Cheng SW, Moradian A, Morin RD, Mungall AJ, Meissner B, Boyle M, Marquez VE, Marra MA, Gascoyne RD, Humphries RK, Arrowsmith CH, Morin GB, Aparicio SA. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation. Blood. 117(8):2451-9. (2011)

Deutsch GB, Zielonka EM, Coutandin D, Weber TA, Sch�fer B, Hannewald J, Luh LM, Durst FG, Ibrahim M, Hoffmann J, Niesen FH, Sent�rk A, Kunkel H, Brutschy B, Schleiff E, Knapp S, Acker-Palmer A, Grez M, McKeon F, D�tsch V. DNA damage in oocytes induces a switch of the quality control factor TAp63a from dimer to tetramer. Cell. 144(4):566-76. (2011)

Busam RD, Thorsell AG, Flores A, Hammarstr�m M, Persson C, Obrink B, Hallberg BM. Structural Basis of Tumor Suppressor in Lung Cancer 1 (TSLC1) Binding to Differentially Expressed in Adenocarcinoma of the Lung (DAL-1/4.1B). J Biol Chem. 286(6):4511-6. (2011)

Shloush J, Vlassov JE, Engson I, Duan S, Saridakis V, Dhe-Paganon S, Raught B, Sheng Y, Arrowsmith CH. Structural and functional comparison of the RING domains of two p53 E3 ligases, Mdm2 and Pirh2. J Biol Chem. 286(6):4796-808 (2011)

Artz JD, Wernimont AK, Dunford JE, Schapira M, Dong A, Zhao Y, Lew J, Russell RG, Ebetino FH, Oppermann U, Hui R. Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites. J Biol Chem. 286(5):3315-22 (2011)

Adams-Cioaba MA, Krupa JC, Xu C, Mort JS, Min J. Structural basis for the recognition and cleavage of histone H3 by cathepsin L. Nat Commun. 0.220138888888889 (2011)

Fedorov O, Huber K, Eisenreich A, Filippakopoulos P, King O, Bullock AN, Szklarczyk D, Jensen LJ, Fabbro D, Trappe J, Rauch U, Bracher F, Knapp S. Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing Chem Biol. 18(1):67-76. (2011)

Sattler JM, Ganter M, Hliscs M, Matuschewski K, Sch�ler H. Actin regulation in the malaria parasite. Eur J Cell Biol. Epub ahead of print (2011)

Bountra C, Oppermann U, Heightman TD. Animal Models of Epigenetic Regulation in Neuropsychiatric Disorders. Curr Top Behav Neurosci. 7:281-322. (2011)

Thalhammer A, Mecinovic J, Loenarz C, Tumber A, Rose NR, Heightman TD, Schofield CJ. Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates. Org Biomol Chem. 9(1):127-35. (2011)

Zadjali F, Pike AC, Vesterlund M, Sun J, Wu C, Li SS, R�nnstrand L, Knapp S, Bullock AN, Flores-Morales A. Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase. J Biol Chem. 286(1):480-90. (2011)

Kaustov L, Quyang H, Amaya M, Lemak A, Nady N, Duan S, Wasney G, Li Z, Vedadi M, Schapira M, Min J, Arrowsmith CH. Recognition and specificity determinants of the human Cbx chromodomains. J Biol Chem. 286(1):521-9. (2011)

Marsden BD, Abagyan R, Lee WH. Visualisation and Efficient Communication in Structure-Based Lead Discovery. In silico Lead Discovery Published by Bentham Science (2011)

Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, Keates T, Hickman TT, Felletar I, Philpott M, Munro S, McKeown MR, Wang Y, Christie AL, West N, Cameron MJ, Schwartz B, Heightman TD, La Thangue N, French CA, Wiest O, Kung AL, Knapp S, Bradner JE. Selective inhibition of BET bromodomains. Nature. 468(7327):1067-73. (2010)

Leung IK, Krojer TJ, Kochan GT, Henry L, von Delft F, Claridge TD, Oppermann U, McDonough MA, Schofield CJ. Structural and mechanistic studies on ?-butyrobetaine hydroxylase. Chem Biol. 17(12):1316-24. (2010)

Johansson C, Roos AK, Montano SJ, Sengupta R, Filippakopoulos P, Guo K, von Delft F, Holmgren A, Oppermann U, Kavanagh KL. The crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activity. Biochem J. 433(2):303-11. (2010)

Froese DS, Kochan G, Muniz J, Wu X, Gileadi C, Ugochukwu E, Krysztofinska E, Gravel RA, Oppermann U, Yue WW. Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-coa mutase and insight into their complex formation. J Biol Chem. 285(49):38204-13. (2010)

Welin M, Egeblad L, Johansson A, Stenmark P, Wang L, Flodin S, Nyman T, Tr�saugues L, Kotenyova T, Johansson I, Eriksson S, Eklund H, Nordlund P. Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1. FEBS J. 277(23):4920-30. (2010)

Mari�o K, Sampaio-G�ther ML, Wernimont AK, Amani M, Hui R, Ferguson MA. Identification, subcellular localization, biochemical properties and high-resolution crystal structure of Trypanosoma brucei UDP-glucose pyrophosphorylase. Glycobiology. 20(12):1619-30. (2010)

Tong Y, Tempel W, Wang H, Yamada K, Shen L, Senisterra GA, MacKenzie F, Chishti AH, Park HW. Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1. Proc Natl Acad Sci 107(47):20346-51. (2010)

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Pilka ES, Niesen FH, Lee WH, El-Hawari Y, Dunford JE, Kochan G, Wsol V, Martin HJ, Maser E, Oppermann U. Structural basis for substrate specificity in human monomeric carbonyl reductases. PLoS One. 4(10):e7113. (2009)

Tong Y, Tempel W, Nedyalkova L, Mackenzie F, Park HW. Crystal structure of the N-acetylmannosamine kinase domain of GNE. PLoS One. 4(10):e7165. (2009)

Bullock AN, Russo S, Amos A, Pagano N, Bregman H, Debreczeni JE, Lee WH, von Delft F, Meggers E, Knapp S. Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor. PLoS One. 4(10):e7112. (2009)

Eryilmaz J, Pan P, Amaya MF, Allali-Hassani A, Dong A, Adams-Cioaba MA, Mackenzie F, Vedadi M, Min J. Structural studies of a four-MBT repeat protein MBTD1. PLoS One. 4(10):e7274. (2009)

Alag R, Bharatham N, Dong A, Hills T, Harikishore A, Widjaja AA, Shochat SG, Hui R, Yoon HS. Crystallographic structure of the tetratricopeptide repeat domain of Plasmodium falciparum FKBP35 and its molecular interaction with Hsp90 C-terminal pentapeptide. Protein Sci. 18(10):2115-24. (2009)

Thorsell AG, Persson C, Gr�slund S, Hammarstr�m M, Busam RD, Hallberg BM. Crystal structure of human diphosphoinositol phosphatase 1. Proteins. 77(1):242-6 (2009)

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Weigelt J. The case for open-access chemical biology. A strategy for pre-competitive medicinal chemistry to promote drug discovery. EMBO Rep 10(9):941-5 (2009)

Campagna-Slater V, Schapira M. Evaluation of Virtual Screening as a Tool for Chemical Genetic Applications. J Chem Inf Model. 49(9):2082-91. (2009)

Wu H, Min J, Antoshenko T, Plotnikov AN. Crystal structures of human CDY proteins reveal a crotonase-like fold. Proteins. 76(4):1054-61. (2009)

M�ller S, Knapp S. Out of the box binding determines specificity of SH2 domain interaction. Structure. 17(8):1040-1 (2009)

Choi Y, Syeda F, Walker JR, Finerty PJ Jr, Cuerrier D, Wojciechowski A, Liu Q, Dhe-Paganon S, Gray NS. Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 19(15):4467-70. (2009)

Davis TL, Walker JR, Allali-Hassani A, Parker SA, Turk BE, Dhe-Paganon S. Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases. FEBS J. 276(16):4395-404. (2009)

Sibley LD, Qiu W, Fentress S, Taylor SJ, Khan A, Hui R. Forward genetics in Toxoplasma gondii reveals a family of rhoptry kinases that mediates pathogenesis. Eukaryot Cell 8(8):1085-93 (2009)

Picaud SS, Muniz JR, Kramm A, Pilka ES, Kochan G, Oppermann U, Yue WW. Crystal structure of human carbonic anhydrase-related protein VIII reveals the basis for catalytic silencing. Proteins. 76(2):507-11. (2009)

Kimple AJ, Soundararajan M, Hutsell SQ, Roos AK, Urban DJ, Setola V, Temple BR, Roth BL, Knapp S, Willard FS, Siderovski DP. Structural determinants of G-protein {alpha} subunit selectivity by regulator of G-protein signaling 2 (RGS2). J Biol Chem. 284(29):19402-11 (2009)

Powlowski J, Mahajan S, Schapira M, Master ER. Substrate recognition and hydrolysis by a fungal xyloglucan-specific family 12 hydrolase. Carbohydr Res. 344(10):1175-9. (2009)

Crowther GJ, Napuli AJ, Thomas AP, Chung DJ, Kovzun KV, Leibly DJ, Castaneda LJ, Bhandari J, Damman CJ, Hui R, Hol WG, Buckner FS, Verlinde CL, Zhang Z, Fan E, van Voorhis WC. Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands. J Biomol Screen. 14(6):700-7. (2009)

Edwards AM, Bountra C, Kerr DJ, Willson TM. Open access chemical and clinical probes to support drug discovery. Nat Chem Biol. 5(7):436-40. (2009)

Bunkoczi G, Misquitta S, Wu X, Lee WH, Rojkova A, Kochan G, Kavanagh KL, Oppermann U, Smith S. Structural basis for different specificities of acyltransferases associated with the human cytosolic and mitochondrial fatty acid synthases. Chem Biol. 16(6):667-75 (2009)

Port� S, Valencia E, Yakovtseva EA, Borr�s E, Shafqat N, Debreczeny JE, Pike AC, Oppermann U, Farr�s J, Fita I, Par�s X. Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase pig3. J Biol Chem. 284(25):17194-205 (2009)

Eswaran J, Soundararajan M, Knapp S. Targeting group II PAKs in cancer and metastasis. Cancer Metastasis Rev. 28(1-2):209-17 (2009)

Magnusdottir A, Johansson I, Dahlgren LG, Nordlund P, Berglund H. Enabling IMAC purification of low abundance recombinant proteins from E. coli lysates. Nat Methods. 6(7):477-8 (2009)

Tong Y, Park I, Hong BS, Nedyalkova L, Tempel W, Park HW. Crystal structure of human eIF5A1: insight into functional similarity of human eIF5A1 and eIF5A2. Proteins. 75(4):1040-5 (2009)

Edwards A. Large-scale structural biology of the human proteome. Annu Rev Biochem. 78:541-68. (2009)

Kochan G, Pilka ES, von Delft F, Oppermann U, Yue WW. Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A. J Mol Biol. 388(5):997-1008 (2009)

Lehti� L, Jemth AS, Collins R, Loseva O, Johansson A, Markova N, Hammarstr�m M, Flores A, Holmberg-Schiavone L, Weigelt J, Helleday T, Sch�ler H, Karlberg T. Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3. J Med Chem. 52(9):3108-11 (2009)

Huck K, Feyen O, Niehues T, R�schendorf F, H�bner N, Laws HJ, Telieps T, Knapp S, Wacker HH, Meindl A, Jumaa H, Borkhardt A. Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation. J Clin Invest. 119(5):1350-8. (2009)

Collins R, Karlberg T, Lehti� L, Sch�tz P, van den Berg S, Dahlgren LG, Hammarstr�m M, Weigelt J, Sch�ler H. The DEXD/H-box RNA Helicase DDX19 Is Regulated by an {alpha}-Helical Switch. J Biol Chem. 284(16):10296-300 (2009)

Collins R, Karlberg T, Lehti� L, Sch�tz P, van den Berg S, Dahlgren LG, Hammarstr�m M, Weigelt J, Sch�ler H. The DExD/H-box RNA helicase DDX19 is regulated by an alpha -helical switch. J Biol Chem. 284(16):10296-300 (2009)

Min T, Vedadi M, Watson DC, Wasney GA, Munger C, Cygler M, Matte A, Young NM. Specificity of Campylobacter jejuni adhesin PEB3 for phosphates and structural differences among its ligand complexes. Biochemistry. 48(14):3057-67 (2009)

Qiu W, Wernimont A, Tang K, Taylor S, Lunin V, Schapira M, Fentress S, Hui R, Sibley LD. Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondii. EMBO J. 28(7):969-79 (2009)

Wernimont A, Edwards A. In situ proteolysis to generate crystals for structure determination: an update. PLoS One. 4(4):e5094 (2009)

Gingras MC, Zhang YL, Kharitidi D, Barr AJ, Knapp S, Tremblay ML, Pause A. HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain. PLoS ONE. 4(4):e5105 (2009)

Elkins JM, Amos A, Niesen FH, Pike AC, Fedorov O, Knapp S. Structure of dystrophia myotonica protein kinase. Protein Sci. 18(4):782-91 (2009)

Guo Y, Nady N, Qi C, Allali-Hassani A, Zhu H, Pan P, Adams-Cioaba MA, Amaya MF, Dong A, Vedadi M, Schapira M, Read RJ, Arrowsmith CH, Min J. Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2. Nucleic Acids Res. 37(7):2204-10 (2009)

Petrie KA, Lee WH, Bullock AN, Pointon JJ, Smith R, Russell RG, Brown MA, Wordsworth BP, Triffitt JT. Novel mutations in ACVR1 result in atypical features in two fibrodysplasia ossificans progressiva patients. PLoS ONE. 4(3):e5005 (2009)

Willard FS, Willard MD, Kimple AJ, Soundararajan M, Oestreich EA, Li X, Sowa NA, Kimple RJ, Doyle DA, Der CJ, Zylka MJ, Snider WD, Siderovski DP. Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector. PLoS ONE. 4(3):e4884 (2009)

Lee WH, Lukacik P, Guo K, Ugochukwu E, Kavanagh KL, Marsden B, Oppermann U. Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4. Mol Cell Endocrinol. 301(1-2):199-204. (2009)

El-Hawari Y, Favia AD, Pilka ES, Kisiela M, Oppermann U, Martin HJ, Maser E. Analysis of the substrate-binding site of human carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis. Chem Biol Interact. 178(1-3):234-41 (2009)

Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, J�rnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. Chem Biol Interact. 178(1-3):94-8. (2009)

Bray JE, Marsden BD, Oppermann U. The human short-chain dehydrogenase/reductase (SDR) superfamily: A bioinformatics summary. Chem Biol Interact. 178(1-3):99-109. (2009)

Bullock AN, Das S, Debreczeni JE, Rellos P, Fedorov O, Niesen FH, Guo K, Papagrigoriou E, Amos AL, Cho S, Turk BE, Ghosh G, Knapp S. Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation. Structure. 17(3):352-62 (2009)

Edelmann MJ, Iph�fer A, Akutsu M, Altun M, di Gleria K, Kramer HB, Fiebiger E, Dhe-Paganon S, Kessler BM. Structural basis and specificity of human otubain 1-mediated deubiquitination. Biochem J. 418(2):379-90. (2009)

Senisterra GA, Finerty PJ Jr. High throughput methods of assessing protein stability and aggregation Mol. BioSyst. 5(3):217-23 (2009)

Tempel W, Wu H, Dombrovsky L, Zeng H, Loppnau P, Zhu H, Plotnikov AN, Bochkarev A. An intact SAM-dependent methyltransferase fold is encoded by the human endothelin-converting enzyme-2 gene. Proteins. 74(3):789-93. (2009)

Pardee KI, Xu X, Reinking J, Schuetz A, Dong A, Liu S, Zhang R, Tiefenbach J, Lajoie G, Plotnikov AN, Botchkarev A, Krause HM, Edwards A. The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta. PLoS Biol. 7(2):e43. (2009)

Adams-Cioaba MA, Min J. Structure and function of histone methylation binding proteins. Biochem Cell Biol. 87(1):93-105 (2009)

Huang X, Finerty P Jr, Walker JR, Butler-Cole C, Vedadi M, Schapira M, Parker SA, Turk BE, Thompson DA, Dhe-Paganon S. Structural insights into the inhibited states of the Mer receptor tyrosine kinase. J Struct Biol. 165(2):88-96. (2009)

Ng SS, Yue WW, Oppermann U, Klose RJ. Dynamic protein methylation in chromatin biology Cell Mol Life Sci. 66(3):407-22. (2009)

Sun Q, Collins R, Huang S, Holmberg-Schiavone L, Anand GS, Tan CH, van-den-Berg S, Deng LW, Moore PK, Karlberg T, Sivaraman J. Structural Basis for the inhibition mechanism of human cystathionine-gamma -Lyase: An enzyme responsible for the production of H2S. J Biol Chem. 284(5):3076-85. (2009)

Pike AC, Shrestha B, Popuri V, Burgess-Brown N, Muzzolini L, Costantini S, Vindigni A, Gileadi O. Structure of the human RECQ1 helicase reveals a putative strand-separation pin. Proc Natl Acad Sci U S A. 106(4):1039-44. (2009)

Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, Savitsky P, Burgess-Brown NA, M�ller S, Knapp S. Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell. 136(2):352-63. (2009)

Zimmermann TJ, Niesen FH, Pilka ES, Knapp S, Oppermann U, Maier ME. Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone. Bioorg Med Chem. 17(2):530-6. (2009)

Scheeff ED, Eswaran J, Bunkoczi G, Knapp S, Manning G. Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site. Structure. 17(1):128-38. (2009)

Poondra RR, Kumar NN, Bijian K, Prakesch M, Campagna-Slater V, Reayi A, Reddy PT, Choudhry A, Barnes ML, Leek DM, Daroszewska M, Lougheed C, Xu B, Schapira M, Alaoui-Jamali MA, Arya P. Discovery of Indoline-Based, Natural-Product-like Compounds as Probes of Focal Adhesion Kinase Signaling Pathways. J Comb Chem. Epub ahead of print (2009)

Magnusdottir A, Stenmark P, Flodin S, Nyman T, Kotenyova T, Gr�slund S, Ogg D, Nordlund P. The structure of the PP2A regulatory subunit B56gamma: The remaining piece of the PP2A jigsaw puzzle. Proteins 74(1):212-21. (2009)

Pike AC. X-ray crystallography of agonist/antagonist-bound receptors. Methods Mol Biol. 505:51-66 (2009)

Artz JD, Dunford JE, Arrowood MJ, Dong A, Chruszcz M, Kavanagh KL, Minor W, Russell RG, Ebetino FH, Oppermann U, Hui R. Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis. Chem Biol. 15(12):1296-306 (2008)

Kavanagh KL, J�rnvall H, Persson B, Oppermann U. The SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes. Cell Mol Life Sci. 65(24):3895-906. (2008)

Tr�saugues L, Stenmark P, Sch�ler H, Flodin S, Welin M, Nyman T, Hammarstr�m M, Moche M, Gr�slund S, Nordlund P. The crystal structure of human cleavage and polyadenylation specific factor-5 reveals a dimeric Nudix protein with a conserved catalytic site Proteins 73(4):1047-52. (2008)

Rose NR, Ng SS, Mecinovic J, Li�nard BM, Bello SH, Sun Z, McDonough MA, Oppermann U, Schofield CJ. Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases. J Med Chem. 51(22):7053-6. (2008)

Prakesch M, Bijian K, Campagna-Slater V, Quevillon S, Joseph R, Wei CQ, Sesmilo E, Reayi A, Poondra RR, Barnes ML, Leek DM, Xu B, Lougheed C, Schapira M, Alaoui-Jamali M, Arya P. Building skeletally diverse architectures on the Indoline Scaffold: the discovery of a chemical probe of focal adhesion kinase signaling networks. Bioorg Med Chem. 16(21):9596-602. (2008)

Herman MD, Nyman T, Welin M, Lehti� L, Flodin S, Tr�saugues L, Kotenyova T, Flores A, Nordlund P. Completing the family portrait of the anti-apoptotic Bcl-2 proteins: Crystal structure of human Bfl-1 in complex with Bim FEBS Lett. 582(25-26):3590-4. (2008)

Hurtado-Guerrero R, Raimi OG, Min J, Zeng H, Vallius L, Shepherd S, Ibrahim AF, Wu H, Plotnikov AN, van Aalten DM. Structural and kinetic differences between human and Aspergillus fumigatus D-glucosamine-6-phosphate N-acetyltransferase. Biochem J. 415(2):217-23. (2008)

Avvakumov GV, Walker JR, Xue S, Li Y, Duan S, Bronner C, Arrowsmith CH, Dhe-Paganon S. Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1 Nature 455(7214):822-5 (2008)

Eydoux C, Spinelli S, Davis TL, Walker JR, Seitova A, Dhe-Paganon S, De Caro A, Cambillau C, Carri�re F. Structure of Human Pancreatic Lipase-Related Protein 2 with the Lid in an Open Conformation(,). Biochemistry. 47(36):9553-64. (2008)

Filippakopoulos P, Kofler M, Hantschel O, Gish GD, Grebien F, Salah E, Neudecker P, Kay LE, Turk BE, Superti-Furga G, Pawson T, Knapp S. Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation. Cell 134(5):793-803 (2008)

Wu X, Oppermann M, Berndt KD, Bergman T, J�rnvall H, Knapp S, Oppermann U. Thermal unfolding of the archaeal DNA and RNA binding protein Ssh10. Biochem Biophys Res Commun. 373(4):482-7 (2008)

Miller ML, Jensen LJ, Diella F, J�rgensen C, Tinti M, Li L, Hsiung M, Parker SA, Bordeaux J, Sicheritz-Ponten T, Olhovsky M, Pasculescu A, Alexander J, Knapp S, Blom N, Bork P, Li S, Cesareni G, Pawson T, Turk BE, Yaffe MB, Brunak S, Linding R. Linear motif atlas for phosphorylation-dependent signaling Sci Signal. 1(35):ra2 (2008)

Kang CB, Hong Y, Dhe-Paganon S, Yoon HS. FKBP family proteins: immunophilins with versatile biological functions. Neurosignals. 16(4):318-25. (2008)

Edwards A. Open-source science to enable drug discovery. Drug Discov Today. 13(17-18):731-3 (2008)

Eswaran J, Soundararajan M, Kumar R, Knapp S UnPAKing the class differences among p21-activated kinases. Trends Biochem Sci. 33(8):394-403 (2008)

Baumli S, Lolli G, Lowe ED, Troiani S, Rusconi L, Bullock AN, Debreczeni JE, Knapp S, Johnson LN. The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation. EMBO J. 27(13):1907-18 (2008)

Wu H, Min J, Zeng H, Plotnikov AN. Crystal structure of the methyltransferase domain of human TARBP1. Proteins 72(1):519-525 (2008)

Strushkevich N, Usanov SA, Plotnikov AN, Jones G, Park HW. Structural analysis of CYP2R1 in complex with vitamin D3 J Mol Biol. 380(1):95-106 (2008)

Wu H, Min J, Zeng H, McCloskey DE, Ikeguchi Y, Loppnau P, Michael AJ, Pegg AE, Plotnikov AN. Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism. J Biol Chem. 283(23):16135-46. (2008)

Nady N, Min J, Kareta MS, Ch�din F, Arrowsmith CH. A SPOT on the chromatin landscape? Histone peptide arrays as a tool for epigenetic research. Trends Biochem Sci. 33(7):305-13 (2008)

Bochkarev A, Tempel W. High throughput crystallography at SGC Toronto: an overview Methods Mol Biol. 426:515-21. (2008)

Davis TL, Walker JR, Loppnau P, Butler-Cole C, Allali-Hassani A, Dhe-Paganon S. Autoregulation by the juxtamembrane region of the human ephrin receptor tyrosine kinase A3 (EphA3). Structure 16(6):873-84. (2008)

Senisterra GA, Hong BS, Park HW, Vedadi M. Application of High-Throughput Isothermal Denaturation to Assess Protein Stability and Screen for Ligands. J Biomol Screen. 13(5):337-42 (2008)

Thorsell AG, Persson C, Voevodskaya N, Busam RD, Hammarstr�m M, Gr�slund S, Gr�slund A, Hallberg BM. Structural and biophysical characterization of human myo-inositol oxygenase. J Biol Chem. 15209-15216 (2008)

Lehti� L, Collins R, van den Berg S, Johansson A, Dahlgren LG, Hammarstr�m M, Helleday T, Holmberg-Schiavone L, Karlberg T, Weigelt J. Zinc binding catalytic domain of human tankyrase 1. J Mol Biol. 379(1):136-45 (2008)

Nyman T, Stenmark P, Flodin S, Johansson I, Hammarstr�m M, Nordlund P. The Crystal Structure of the Human Toll-like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer. J Biol Chem 283(18):11861-5 (2008)

Burgess-Brown NA, Sharma S, Sobott F, Loenarz C, Oppermann U, Gileadi O. Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study. Protein Expr Purif. 59(1):94-102 (2008)

Structural Genomics Consortium; China Structural Genomics Consortium; Northeast Structural Genomics Consortium, Gr�slund S, Nordlund P, Weigelt J, Hallberg BM, Bray J, Gileadi O, Knapp S, Oppermann U, Arrowsmith C, Hui R, Ming J, dhe-Paganon S, Park HW, Savchenko A, Yee A, Edwards A, Vincentelli R, Cambillau C, Kim R, Kim SH, Rao Z, Shi Y, Terwilliger TC, Kim CY, Hung LW, Waldo GS, Peleg Y, Albeck S, Unger T, Dym O, Prilusky J, Sussman JL, Stevens RC, Lesley SA, Wilson IA, Joachimiak A, Collart F, Dementieva I, Donnelly MI, Eschenfeldt WH, Kim Y, Stols L, Wu R, Zhou M, Burley SK, Emtage JS, Sauder JM, Thompson D, Bain K, Luz J, Gheyi T, Zhang F, Atwell S, Almo SC, Bonanno JB, Fiser A, Swaminathan S, Studier FW, Chance MR, Sali A, Acton TB, Xiao R, Zhao L, Ma LC, Hunt JF, Tong L, Cunningham K, Inouye M, Anderson S, Janjua H, Shastry R, Ho CK, Wang D, Wang H, Jiang M, Montelione GT, Stuart DI, Owens RJ, Daenke S, Sch�tz A, Heinemann U, Yokoyama S, B�ssow K, Gunsalus KC. Protein production and purification. Nature Methods 5(2):135-46 (2008)

Davis TL, Walker JR, Ouyang H, Mackenzie F, Butler-Cole C, Newman EM, Eisenmesser EZ, Dhe-Paganon S. The crystal structure of human WD40 repeat-containing peptidylprolyl isomerase (PPWD1). FEBS 275(9):2283-95 (2008)

Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundstr�m M, Doyle DA, Siderovski DP. Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. PNAS 105(17):6457-62. (2008)

Eswaran J, Bernad A, Ligos JM, Guinea B, Debreczeni JE, Sobott F, Parker SA, Najmanovich R, Turk BE, Knapp S. Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecture. Structure 16(1):115-24 (2008)

Schuetz A, Min J, Allali-Hassani A, Schapira M, Shuen M, Loppnau P, Mazitschek R, Kwiatkowski NP, Lewis TA, Maglathin RL, McLean TH, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH. Human HDAC7 harbors a class IIa HDAC-specific zinc binding motif and cryptic deacetylase activity. J Biol. Chem 283(17):11355-63 (2008)

Dunford JE, Kwaasi AA, Rogers MJ, Barnett BL, Ebetino FH, Russell RG, Oppermann U, Kavanagh KL. Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase. J Med Chem. 51(7):2187-95 (2008)

Soundararajan M, Turnbull A, Fedorov O, Johansson C, Doyle DA. RhoB can adopt a Mg(2+) free conformation prior to GEF binding Proteins 72(1):498-505 (2008)

Tempel W, Tong Y, Dimov S, Bochkarev A, Park H. First crystallographic models of human TBC domains in the context of a family-wide structural analysis. Proteins 71(1):497-502 (2008)

Gr�slund S, Sagemark J,�Berglund H,� Dahlgren L-G,� Flores A, Hammarstr�m M,� Johansson I, Kotenyova T, Nilsson M, Nordlund P, Weigelt J. The use of systematic N- and C-terminal deletions to promote production and structural studies of recombinant proteins. Protein Expr Purif. . 58(2):210-21 (2008)

Karlberg T, Collins R, van den Berg S, Flores A, Hammarstr�m M, H�gbom M, Holmberg Schiavone L, Uppenberg J. Structure of human argininosuccinate synthetase. Acta Crystallogr D Biol Crystallogr. 64(Pt 3):279-86. (2008)

Pike AC, Rellos P, Niesen FH, Turnbull A, Oliver AW, Parker SA, Turk BE, Pearl LH, Knapp S. Activation by activation loop exchange suggests a novel mechanism of kinase auto-activation. EMBO J 27(4):704-14. (2008)

Weigelt J, McBroom-Cerajewski LD, Schapira M, Zhao Y, Arrowmsmith CH. Structural Genomics and Drug Discovery: All in the Family Curr Opin Chem Biol 12(1):32-9 (2008)

Marsden, B, Knapp, S Doing more than just the structure - Structural Genomics in kinase drug discovery Curr. Opinion Chem Biol 12(1):40-45 (2008)

Hozjan V, Guo K, Wu X, Oppermann U. Ligand supplementation as method to increase soluble heterologous protein production Exp Rev Proteomics 5(1):137-43. (2008)

Bunkoczi G, Pasta S, Joshi A, Wu X, Kavanagh KL, Smith S, Oppermann U. Mechanism and substrate recognition of human holo ACP synthase Chem Biol 14(11):1243-53 (2008)

Ludwig C, Michiels PJ, Wu X, Kavanagh KL, Pilka E, Jansson A, Oppermann U, G�nther UL. SALMON: Solvent accessibility, ligand binding and mapping of ligand orientation by NMR spectroscopy. J. Med Chem 51(1):1-3 (2008)

Shrestha B, Smee C, Gileadi O Baculovirus expression vector system: an emerging host for high-throughput eukaryotic protein expression. Methods Mol Biol. 439:269-89 (2008)

Tong Y, Chugha P, Hota PK, Alviani RS, Li M, Tempel W, Shen L, Park HW, Buck M. Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain. J Biol Chem. 282(51):37215-24. (2007)

Fedorov O, Marsden B, Pogacic V, Rellos P, M�ller S, Bullock AN, Schwaller J, Sundstr�m M, Knapp S. Systematic analysis of inhibitor binding profiles to Ser/Thr kinases. PNAS 104(51):20523-8 (2007)

Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH. L3MBTL1 recognition of mono- and dimethylated histones. Nat Struct Mol Biol. 12):1229-30. (2007)

Simeonov A, Yasgar A, Klumpp C, Zheng W, Shafqat N, Oppermann U, Austin CP, Inglese J. Evaluation of Micro-Parallel Liquid Chromatography (PLC) as a Method for HTS-coupled Actives Verification. Drug Development Technologies 5(6):815-24. (2007)

Bunkoczi G, Pasta S, Joshi A, Wu X, Kavanagh KL, Smith S, Oppermann U. Mechanism and substrate recognition of human holo ACP synthase. Chemistry and Biology 14(11):1243-53 (2007)

Bullock AN, Rodriguez MC, Debreczeni JE, Songyang Z, Knapp S. Structure of the SOCS4-ElonginB/C Complex Reveals a Distinct SOCS Box Interface and the Molecular Basis for SOCS-Dependent EGFR Degradation. Structure 15(11):1493-504 (2007)

Russell RG, Xia Z, Dunford JE, Oppermann U, Kwaasi A, Hulley PA, Kavanagh KL, Triffitt JT, Lundy MW, Phipps RJ, Barnett BL, Coxon FP, Rogers MJ, Watts NB, Ebetino FH. Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy. Ann N Y Acad Sci. 1117:209-57. (2007)

Dong A, Xu X, Edwards AM; Midwest Center for Structural Genomics; Structural Genomics Consortium, Chang C, Chruszcz M, Cuff M, Cymborowski M, Di Leo R, Egorova O, Evdokimova E, Filippova E, Gu J, Guthrie J, Ignatchenko A, Joachimiak A, Klostermann N, Kim Y, Korniyenko Y, Minor W, Que Q, Savchenko A, Skarina T, Tan K, Yakunin A, Yee A, Yim V, Zhang R, Zheng H, Akutsu M, Arrowsmith C, Avvakumov GV, Bochkarev A, Dahlgren LG, Dhe-Paganon S, Dimov S, Dombrovski L, Finerty P Jr, Flodin S, Flores A, Gr�slund S, Hammerstr�m M, Herman MD, Hong BS, Hui R, Johansson I, Liu Y, Nilsson M, Nedyalkova L, Nordlund P, Nyman T, Min J, Ouyang H, Park HW, Qi C, Rabeh W, Shen L, Shen Y, Sukumard D, Tempel W, Tong Y, Tresagues L, Vedadi M, Walker JR, Weigelt J, Welin M, Wu H, Xiao T, Zeng H, Zhu H. In Situ Proteolysis for Protein Crystallization and Structure Determination. Nature Methods 4(12):1019-21 (2007)

Krajewski W, Collins R, Holmberg-Schiavone L, Jones TA, Karlberg T,and Mowbray S Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes, and provide opportunities for drug and herbicide design. J. Mol. Biol. 375(1):217-28. (2007)

Bunkoczi G, Salah E, Filippakopoulos P, Fedorov O, Muller S, Sobott F, Parker SA, Zhang H, Min W, Turk BE, Knapp S. Structural and Functional Characterization of the Human Protein Kinase ASK1. Structure (10):1215-26. (2007)

Dufe VT, Qiu W, M�ller IB, Hui R, Walter RD, Al-Karadaghi S. Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO. J Mol Biol. 373(1):167-77. (2007)

Wu H, Dombrovsky L, Tempel W, Martin F, Loppnau P, Goodfellow GH, Grant DM, Plotnikov AN. Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases. J Biol Chem. 282(41):30189-97. (2007)

Gileadi O, Knapp S, Lee WH, Marsden BD, Muller S, Niesen FH, Kavanagh KL, Ball LJ, von Delft F, Doyle DA, Oppermann UC, Sundstrom M. The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins J Struct Funct Genomics 15(10):1215-26 (2007)

Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C. Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD(+). PLoS Biol. 5(10):e263 (2007)

Hong BS, Senisterra G, Rabeh WM, Vedadi M, Leonardi R, Zhang YM, Rock CO, Jackowski S, Park HW. Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder. J Biol Chem. 282(38):27984-93 (2007)

H�gbom M, Collins R, van den Berg S, Jenvert RM, Karlberg T, Kotenyova T, Flores A, Hedestam GB, Schiavone LH. Crystal Structure of conserved domains 1 and 2 of the human DEAD-box helicase DDX3X in complex with the mononucleotide AMP J Mol Biol 372(1):150-9 (2007)

Niesen FH, Berglund H, Vedadi M. The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability. Nat. Protocol 2(9):2212-21. (2007)

Wu H, Min J, Ikeguchi Y, Zeng H, Dong A, Loppnau P, Pegg AE, Plotnikov AN. Structure and Mechanism of Spermidine Synthases. Biochemistry 46(28):8331-8339 (2007)

Pogacic V, Bullock AN, Fedorov O, Filippakopoulos P, Gasser C, Biondi A, Meyer-Monard S, Knapp S, and Schwaller J Structural Analysis Identifies Imidazo[1,2-b]Pyridazines as PIM Kinase Inhibitors with In vitro Antileukemic Activity Cancer Research 67: 6916-6924 (2007)

Oliver AW, Knapp S, Pearl L. Activation segment exchange: a common mechanism of kinase autophosphorylation? TIBS. 32(8):351-6 (2007)

Ng SS, Kavanagh KL, McDonough MA, Butler D, Pilka ES, Lienard BM, Bray JE, Savitsky P, Gileadi O, von Delft F, Rose NR, Offer J, Scheinost JC, Borowski T, Sundstrom M, Schofield CJ, Oppermann U. Crystal Structures of Histone Demethylase JMJD2A Reveal Basis for Substrate Specificity. Nature 448(7149):87-91 (2007)

Shanmuganatham KK, Ravichandran M, Howe MM, Park HW. Crystallization and preliminary X-ray analysis of phage Mu activator protein C in a complex with promoter DNA. Acta Crystallogr Sect F Struct Biol Cryst Commun. 63(Pt 7):620-3. (2007)

Schuetz A, Bernstein G, Dong A, Antoshenko T, Wu H, Loppnau P, Bochkarev A, Plotnikov AN. Crystal Structure of a Binary Complex Between Human GCN5 Histone Acetyltransferase Domain and Acetyl Coenzyme A Proteins: structure, function and bioinformatics 68(1):403-7 (2007)

Walld�n K,�Stenmark P, Nyman T,�Flodin S,�Gr�slund S,�Loppnau P,�Bianchi V and Nordlund P. Crystal Structure of Human Cytosolic 5'-Nucleotidase: Insights into Allosteric Regulation and Substrate Recognition J Biol Chem 282(24):17828-36 (2007)

Lorca GL, Ezersky A, Lunin VV, Walker JR, Altamentova S, Evdokimova E, Vedadi M, Bochkarev A, Savchenko A. Glyoxylate and pyruvate are antagonistic effectors of the Escherichia coli IclR transcriptional regulator. J Biol Chem. 282(22):16476-91. (2007)

Sundqvist G, Stenvall M, Berglund H, Ottosson J, Brumer H. A General, Robust Method for the Quality Control of Intact Proteins using LC-ESI-MS J Chromatogr B Analyt Technol Biomed Life Sci. 852(1-2):188-94 (2007)

Allai-Hassani A, Pan W, Dombrovski L, Nojmanovich R, Tempel W, Dong A, Loppnau P, Martin F, Thorton J, Edwards AM, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH Structural and Chemical Profiling of the Human Cytosolic Sulfotransferases PLoS Biology 5(6):e165 (2007)

Rosettani P, Knapp S, Vismara MG, Rusconi L, Cameron AD. Structures of the Human eIF4E Homologous Protein, h4EHP in its m7GTP-bound and Unliganded forms J. Mol. Biol. 368(3):691-705 (2007)

Fedorov O, Sundstr�m M, Marsden BD and Knapp S. Insights for the Development of Specific Kinase Inhibitors by Targeted Structural Genomics. Drug Discovery Today 12(9-10): 365-72 (2007)

Wu H, Horton JR, Battaile K, Allali-Hassani A, Martin F, Zeng H, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Cheng X. Structural basis of allele variation of human thiopurine-S-methyltransferase Proteins 67(1):198-208 (2007)

Baminger B, Ludwiczek ML, Kontaxis G, Knapp S, Konrat R. Protein-protein interaction site mapping using NMR-detected mutational scanning. J Biomol NMR. 38(2):133-7 (2007)

Lukacik P, Keller B, Bunkoczi G, Kavanagh KL, Lee WH, Adamski J, Oppermann U, Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity Biochem J 402(3):419-27 (2007)

Bello AM, Poduch E, Fujihashi M, Amani M, Li Y, Crandall I, Hui R, Lee PI, Kain KC, Pai EF, Kotra LP. A Potent, Covalent Inhibitor of Orotidine 5'-Monophosphate Decarboxylase with Antimalarial Activity J Med Chem. 50(5): 915-921 (2007)

Wu X, Knapp S, Stamp A, Stammers DK, Jornvall H, Dellaporta SL, Oppermann U. Biochemical characterization of TASSELSEED 2, an essential plant short-chain dehydrogenase/ reductase with broad spectrum activities. FEBS 274(5):1172-82 (2007)

Rellos P, Ivins FJ, Baxter JE, Pike A, Nott TJ, Parkinson DM, Das S, Howell S, Federov O, Shen QY, Fry AM, Knapp S, Smerdon SJ. Structure and regulation of the human NEK2 centrosomal kinase. J Biol Chem. 282(9):6833-6842 (2007)

Schuetz A, Min J, Antoshenko T, Wang CL, Allali-Hassani A, Dong A, Loppnau P, Vedadi M, Bochkarev A, Sternglanz R, Plotnikov AN. Structural Basis of Inhibition of the Human NAD(+)-Dependent Deacetylase SIRT5 by Suramin. Structure. 15(3):377-89 (2007)

Wu X , Lukacik P, Kavanagh KL, Oppermann U SDR-type human hydroxysteroid dehydrogenases involved in steroid hormone activation. Mol Cell Endocrinol 265-266:71-6 (2007)

Eswaran J, Lee WH, Debreczeni JE, Filippakopoulos P, Turnbull A, Fedorov O, Deacon SW, Peterson JR and Knapp S. Crystal structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs. Structure 201-13 (2007)

Davis TL, Walker JR, Finerty PJ Jr, Mackenzie F, Newman EM, Dhe-Paganon S. The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. J Mol Biol 366(1):216-29 (2007)

Stenmark P, Kursula P, Flodin S, Graslund S, Landry R, Nordlund P, Schuler H. Crystal structure of Human Inosine Triphosphatase: Substrate Binding and Implication of the ITPA Deficiency Mutation P32T Journal of Biological Chemistry 282(5):3182-7 (2007)

Johansson C , Kavanagh KL, Gileadi O , Oppermann U Reversible Sequestration of Active Site cysteines in a 2Fe2S-bridged dimer provides a mechanism for mitochondrial glutaredoxin regulation. J Biol Chem 282(5):3077-82 (2007)

Soundararajan M, Yang X, Elkins JM, Sobott F and Doyle DA The Centaurin Gamma-1 GTPase-like domain functions as an NTPase. Biochem J. 401(3):679-88 (2007)

Stenmark P, Ogg D, Flodin S, Flores A, Kotenyova T, Nyman T, Nordlund P, Kursula P. The structure of human collapsin response mediator protein 2, a regulator of axonal growth Journal of Neurochemistry. 101(4):906-917 (2007)

Najmanovich RJ, Allali-Hassani A, Morris RJ, Dombrovski L, Pan PW, Vedadi M, Plotnikov AN, Arrowsmith C, Edwards AM and Thornton JM Analysis of binding site similarity, small molecule similarity and experimental binding profiles in the human cytosolic. ECCB 23(2):e104-9 (2007)

Gileadi O, Burgess-Brown NA, Colebrook SM, Berridge G, Savitsky P, Smee CEA, Loppnau P, Johansson C, Salah E, and Pantic, N. High Throughput Production of Recombinant Human Proteins for Crystallography. Methods in Molecular Biology, vol. 426 (B. Kobe, M. Guss and T. Huber, eds.) 221- 46 (2007)

Vedadi M, Lew J, Artz J, Amani M, Zhao Y, Dong A, Wasney GA, Gao M, Hills T, Brokx S, Qiu W, Sharma S, Diassiti A, Alam Z, Melone M, Mulichak A, Wernimont A, Bray J, Loppnau P, Plotnikova O, Newberry K, Sundararajan E, Houston S, Walker J, Tempel W, Bochkarev A, Kozieradzki I, Edwards A, Arrowsmith C, Roos D, Kain K, Hui R. Genome-Scale Protein Expression and Structural Biology of Plasmodium falciparum and Related Apicomplexan Organisms. Molecular and Biochemical Parasitology. 151(1):100-10 (2007)

Fedorov OY, Higman VA, Schmieder P, Leidert M, Diehl A, Elkins J, Soundararajan M, Oschkinat H, Ball LJ. Resonance Assignment of the RGS Domain of Human RGS10 Journal of Biomolecular NMR. 38(2):191 (2006)

Senisterra GA, Markin E, Yamazaki K, Hui R, Vedadi M, Awrey DE. Screening for Ligands using a Generic and High-throughput Light-scattering-based Assay. J Biomol Screen 11(8):940-8 (2006)

Avvakumov GV, Walker JR, Xue S, Finerty PJ Jr, Mackenzie F, Newman EM, Dhe-Paganon S. Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8). J Biol Chem 281(49):38061-70 (2006)

Yang, X., Lee, W.H., Sobott, F., Papagrigoriou, E, Robinson, C.V., Grossmann, J.G., Sundstrom, M., Doyle, D.A., Elkins, J.M. Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family. Proc. Natl. Acad. Sci. USA 103(46):17237-42 (2006)

Busam RD, Thorsell A-G, Flores A, Hammarstr�m M, Persson C, and Hallberg BM First Structure of a Eukaryotic Phosphohistidine Phosphatase J Biol Chem 281(45):33830-4 (2006)

Littler DR, Walker JR, She YM, Finerty PJ Jr, Newman EM, Dhe-Paganon S. Structure of human protein kinase C eta (PKCeta) C2 domain and identification of phosphorylation sites. BBRC 349(4):1182-9 (2006)

Barr AJ, Knapp S MAPK-specific tyrosine Phosphatases: New Targets for Drug Discovery? TIPS 27(10):525-30 (2006)

Vedadi M, Niesen FH, Allali-Hassani A, Fedorov OY, Finerty PJ Jr, Wasney GA, Yeung R, Arrowsmith C, Ball LJ, Berglund H, Hui R, Marsden BD, Nordlund P, Sundstrom M, Weigelt J, Edwards AM. Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination. PNAS 103(43):15835-4 (2006)

Kursula P, Schuler H, Flodin S, Nilsson-Ehle P, Ogg DJ, Savitsky P, Nordlund P, Stenmark P. Structures of the hydrolase domain of human 10-formyltetrahydrofolate dehydrogenase and its complex with a substrate analogue. Acta Crystallogr D Biol Crystallogr. 62(Pt 11):1294-9 (2006)

Yee A, Gutmanas A and Arrowsmith CH. NMR in Structural Genomics Curr Opin Stuct Biol. 16(5):611-7 (2006)

Schuetz A, Allali-Hassani A, Mart�n F, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Arrowsmith CH and Min JR. Structural basis for molecular recognition and presentation of histone H3 by WDR5. EMBO 25(18):4245-52 (2006)

Dombrovski L, Dong A, Bochkarev A, Plotnikov AN. Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP). PROTEINS: Structure, Function, and Bioinformatics. 64(4):1091-4 (2006)

Hong BS, Yun MK, Zhang YM, Chohnan S, Rock CO, White SW, Jackowski S, Park HW and Leonardi R. Type II and Type III Pantothenate Kinases: The Same Monomer Fold Creates Dimers with Distinct Catalytic Properties. Structure 14(8):1251-61 (2006)

Magnusdottir A, Stenmark P, Flodin S, Nyman T, Hammarstrom M, Ehn M, Bakali H MA, Berglund H, Nordlund P. The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions. J Biol Chem 281(32):22434-8 (2006)

Kavanagh KL, Dunford JE, Bunkoczi G, Russell GG and Oppermann U. The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding. J Biol Chem 281(31):22004-1 (2006)

Kursula P, Flodin S, Ehn M, Hammarstrom M, Schuler H, Nordlund P, Stenmark P. Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy Acta Crystallograph Sect F Struct Biol Cryst Commun 62(7):613-7 (2006)

Marsden BD, Sundstrom M and Knapp S. High Throughput Structural Characterization of Therapeutic Protein Targets. Expert Opinion in Drug Discovery (EODD) 1(2): 123-136 (2006)

Eswaran J, Debreczeni J.E, Longman E, Barr AJ and Knapp S The crystal structure of human receptor protein tyrosine phosphatase k phosphatase domain 1. Protein Science 15(6):1500-5 (2006)

Barr A.J, Debreczeni J.E, Eswaran J and Knapp S Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution. Proteins 63(4):1132-6 (2006)

Kavanagh KL, Guo K, Dunford JE, Wu X, Knapp S, Ebetino FH, Rogers MJ, Russell GG and Oppermann U. The Molecular Mechanism of Nitrogen-Containing Bisphosphonates as Anti-Osteoporosis Drugs: crystal structure and inhibition of human farnesyl pyrophosphate synthase. PNAS 103(20):7829-34 (2006)

Bullock A.N, Debreczeni J.E, Edwards A.M, Sundstr�m M and Knapp�S Crystal Structure of the SOCS2-ElonginC-ElonginB Complex Defines a Prototypical SOCS-Box Ubiquitin Ligase. PNAS 103(20):7637-42 (2006)

Eswaran J, von Kries J.P, Marsden B, Longman E, Debreczeni J.E, Ugochukwu E, Turnbull A, Lee W.H, Knapp S, Barr A.J. Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7 - a family of human MAP-kinase specific protein tyrosine phosphatases. Biochem J. 395(3): 483-91 (2006)

Guo K, Lukacik P, Papagrigoriou E, Meier M, Lee WH, Adamski J, Oppermann U Characterization of Human DHRS6, an Orphan SDR Enzyme: a Novel, Cytosolic Type 2 R-beta-hydroxybutyrate Dehydrogenase J Biol Chem., 281(15):10291-7 (2006)

Lunin, V.V, Dobrovetsky, E., Khutoreskaya, G., Zhang, R., Joachimiak, A., Bochkarev, A., Maguire, M.E., Edwards, A.M. and Koth C.M. Crystal Structure of the CorA Mg2+ Transporter. Nature 440(7085):833-7. (2006)

Lukacik P, Kavanagh K.L and Oppermann U Structure and function of human 17beta-hydroxysteroid dehydrogenases. Mol Cell Endocrinology 248(1-2):61-71 (2006)

Debreczeni J.E, Bullock A.N, Atilla E, Bregman H, Williams D.S, Knapp S, Meggers E Ruthenium Half-Sandwich Complexes Bound to Protein Kinase Pim-1 Angew. Chemie Intl. Ed. 45(10):1580-5. (2006)

Abagyan R, Lee WH, Raush E, Budagyan L, Totrov M, Sundstrom M and Marsden B. Disseminating structural genomics data to the public: from a data dump to an animated story. TIBS 31(2):76-8 . (2006)

U. Oppermann, K. Kavanagh, K. Guo, S. Ng, P. Lukacik, X. Wu, E. Dubinina, N. Shafqat, J. Bray, B. Marsden, S. Sharma, M. Vedadi, F. von Delft, M. Sundstrom SDR goes SGC: a Structural Genomics Initiative Enzymology and Molecular Biology of Carbonyl Metabolism 12. 235-242 (2006)

Park HW Structure Determination of the Motor Domain of Yeast Kinesin Kar3 by X-ray Crystallography In Methods of Molecular Biology (Walker, J.M., ed) (2006)

Domene C, Vemparala S, Klein ML, Venien-Bryan C, Doyle DA. Role of aromatic localization in the gating process of a potassium channel. Biophys. J 90(1):L01-3 (2006)

Bullock A.N, Debreczeni J.E, Knapp S, Turk�B.E Structure and Substrate Specificity of the Pim-1 Kinase J. Biol. Chem 280(50):41675-82 (2005)

McDonough M.A, Kavanagh K, Searls T, Butler D, Oppermann U and Schofield�C.J Structure of Human Phytanoyl-CoA 2-Hydroxylase Identifies Molecular Mechanisms of Refsum Disease J. Biol. Chem 280(49) 41101-10 (2005)

Bullock A.N, Debreczeni J.E, Fedorov O.Y, Nelson A, Marsden B.D, Knapp S. Structural basis of inhibitor specificity of the human proto-oncogene proviral insertion site in Moloney Murine Leukemia Virus (PIM-1) kinase. Journal of Medicinal Chemistry 48(24):7604-14 (2005)

Ismail SA, Park HW Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase Acta Crystallogr D Biol Crystallogr 61:1508-1513 (2005)

Kuo A, Domene C, Johnson LN, Doyle DA, Venien-Bryan C. Two different conformational states of the KirBac3.1 potassium channel revealed by electron crystallography. Structure 13(10):1463-1472 (2005)

Domene C, Doyle DA, Venien-Bryan C Modelling of an ion channel in its open confirmation Biophys J 89(1): L01-3 (2005)

Elkins JM, PapagrigoriouE, Berridge G, Yang X, Phillips C, Gileadi C, Savitsky P and Doyle DA Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions Protein Science 16(41): 683-94 (2005)

Oppermann U. Carbonyl Reductases: The Complex Relationships of Mammalian Carbonyl- and Quinone-Reducing Enzymes and Their Role in Physiology. Annu Rev Pharmacol Toxicol 47:293-322. (2005)

Oppermann U. Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases? Curr Drug Targets: Immune, endocrine and metabolic disorders 6, 259-269 (2005)

von Delft F Structural genomics, the practical way. European Pharmaceutical Review Issue 4. (2005)

A Edwards, J Bermann and M Sundstrom. Structural Genomics and Drug Discovery. Annual Reports in Medicinal Chemistry. 349-369 (2005)

Edited by M Sundstrom, M Norin and A Edwards Structural Genomics and High Throughput Structural Biology. Published by CRC/Taylor & Francis (2005)

Gulbis JM, Doyle DA Potassium channel structures: do they conform? Curr Opin Struct Biol 14: 440-6 (2004)

Doyle DA Structural changes during ion channel gating. Trends Neurosci 27(6):298-302 (2004)

Doyle DA Structural themes in ion channels. Eur Biophys J 33(3):175-9 (2004)

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