Publications

Sagemark J, Kraulis P, Weigelt J. A software tool to accelerate design of protein constructs for recombinant expression. Protein Expr Purif. 72(2):175-8 (2010)
Vindigni A, Marino F, Gileadi O. Probing the structural basis of RecQ helicase function. Biophys Chem. 149(3):67-77. (2010)
Siponen MI, Wisniewska M, Lehtio L, Johansson I, Svensson L, Raszewski G, Nilsson L, Sigvardsson M, Berglund H. Structural determination of functional domains in Early B-cell Factor (EBF) family of transcription factors reveals similarities to rel DNA binding proteins and a novel dimerisation motif. J Biol Chem. Epub ahead of print (2010)
Bacik JP, Walker JR, Ali M, Schimmer AD, Dhe-Paganon S. Crystal structure of the human ubiquitin-activating enzyme 5 (UBA5) bound to ATP: Mechanistic insights into a minimalistic E1 enzyme. J Biol Chem. 285(26):20273-80 (2010)
Karlberg T, Markova N, Johansson I, Hammarström M, Schütz P, Weigelt J, Schüler H. Structural Basis for the Interaction between Tankyrase-2 and a Potent Wnt-Signaling Inhibitor. J Med Chem. Epub ahead of print (2010)
Filippakopoulos P, Low A, Sharpe TD, Uppenberg J, Yao S, Kuang Z, Savitsky P, Lewis RS, Nicholson SE, Norton RS, Bullock AN. Structural basis for Par-4 recognition by the SPRY domain and SOCS box containing proteins SPSB1, SPSB2 and SPSB4. J Mol Biol. Epub ahead of print (2010)
Himanen JP, Yermekbayeva L, Janes PW, Walker JR, Xu K, Atapattu L, Rajashankar KR, Mensinga A, Lackmann M, Nikolov DB, Dhe-Paganon S. Architecture of Eph receptor clusters. Proc Natl Acad Sci U S A. 107(24):10860-5. (2010)
Brocker C, Lassen N, Estey T, Pappa A, Cantore M, Orlova VV, Chavakis T, Kavanagh KL, Oppermann U, Vasiliou V. Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress. J Biol Chem. 285(24):18452-63. (2010)
Savitsky P, Bray J, Cooper CD, Marsden BD, Mahajan P, Burgess-Brown NA, Gileadi O. High-throughput production of human proteins for crystallization: the SGC experience. J Struct Biol. Epub ahead of print (2010)
Healy S, McDonald MK, Wu X, Yue WW, Kochan G, Oppermann U, Gravel RA. Structural Impact of Human and Escherichia coli Biotin Carboxyl Carrier Proteins on Biotin Attachment. Biochemistry. 49(22):4687-94. (2010)
Brault L, Gasser C, Bracher F, Huber K, Knapp S, Schwaller J. PIM serine/threonine kinases in pathogenesis and therapy of hematological malignancies and solid cancers. Haematologica. 95(6):1004-15. (2010)
Mersmann M, Meier D, Mersmann J, Helmsing S, Nilsson P, Gräslund S, Structural Genomics Consortium, Colwill K, Hust M, Dübel S. Towards proteome scale antibody selections using phage display N Biotechnol.. 27(2):118-28. (2010)
Schütz P, Wahlberg E, Karlberg T, Hammarström M, Collins R, Flores A, Schüler H. Crystal structure of human RNA helicase A (DHX9): Structural basis for unselective nucleotide base binding in a DEAD-box variant protein. J Mol Biol. Epub ahead of print (2010)
Welin M, Nordlund P. Understanding specificity in metabolic pathways--structural biology of human nucleotide metabolism. Biochem Biophys Res Commun. 396(1):157-63. (2010)
Jörnvall H, Hedlund J, Bergman T, Oppermann U, Persson B. Superfamilies SDR and MDR: from early ancestry to present forms. Emergence of three lines, a Zn-metalloenzyme, and distinct variabilities. Biochem Biophys Res Commun. 396(1):125-30. (2010)
Hong BS, Allali-Hassani A, Tempel W, Finerty PJ Jr, Mackenzie F, Dimov S, Vedadi M, Park HW. Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: Single amino acid near the active site influences inhibitor sensitivity. J Biol Chem. 285(21):16330-40. (2010)
Wiens CJ, Tong Y, Esmail MA, Oh E, Gerdes JM, Wang J, Tempel W, Rattner JB, Katsanis N, Park HW, Leroux MR. The Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signalling. J Biol Chem. 285(21):16218-30. (2010)
Lourido S, Shuman J, Zhang C, Shokat KM, Hui R, Sibley LD. Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma. Nature. 465(7296):359-62. (2010)
Shafqat N, Turnbull A, Zschocke J, Oppermann U, Yue WW. Crystal Structures of Human HMG-CoA Synthase Isoforms Provide Insights into Inherited Ketogenesis Disorders and Inhibitor Design. J Mol Biol. 398(4):497-506. (2010)
Radwa?ska K, Tudor-Jones AA, Mizuno K, Pereira GS, Lucchesi W, Alfano I, Lach A, Kaczmarek L, Knapp S, Peter Giese K. Differential regulation of CaMKII inhibitor beta protein expression after exposure to a novel context and during contextual fear memory formation. Genes Brain Behav. Epub ahead of print (2010)
Masoud Vedadi, Cheryl H. Arrowsmith, Abdellah Allali-Hassani, Guillermo Senisterra and Gregory A. Wasney Biophysical Characterization of Recombinant Proteins: A key to higher structural genomics success. J. Struct. Biol. Epub ahead of print (2010)
Huttu J, Singh BK, Bhargav SP, Sattler JM, Schüler H, Kursula I. Crystallization and preliminary structural characterization of the two actin-depolymerization factors of the malaria parasite. Acta Crystallogr Sect F Struct Biol Cryst Commun. 66(Pt 5):583-7. (2010)
Jiang J, Boxer MB, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. , 2010 Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorg Med Chem Lett 20(11):3387-93. (2010)
Kallberg Y, Oppermann U, Persson B. Classification of the short-chain dehydrogenase/reductase superfamily using hidden Markov models. FEBS J. 277(10):2375-86. (2010)
Wernimont AK, Artz JD, Finerty P Jr, Lin YH, Amani M, Allali-Hassani A, Senisterra G, Vedadi M, Tempel W, Mackenzie F, Chau I, Lourido S, Sibley LD, Hui R. Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium. Nat Struct Mol Biol. 17(5):596-601. (2010)
D'Avanzo N, Cheng WW, Xia X, Dong L, Savitsky P, Nichols CG, Doyle DA. Expression and purification of recombinant human inward rectifier k(+) (kcnj) channels in saccharomyces cerevisiae. Protein Expr Purif. 71(1):115-121 (2010)
Weigelt J. Structural genomics - Impact on biomedicine and drug discovery. Exp Cell Res. 316(8):1332-8. (2010)
Kwiatkowski N, Jelluma N, Filippakopoulos P, Soundararajan M, Manak MS, Kwon M, Choi HG, Sim T, Deveraux QL, Rottmann S, Pellman D, Shah JV, Kops GJPL, Knapp S, Gray NS Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat Chem Biol. 6(5):359-68. (2010)
Froese DS, Healy S, McDonald M, Kochan G, Oppermann U, Niesen FH, Gravel RA. Thermolability of mutant MMACHC protein in the vitamin B12-responsive cblC disorder. Mol Genet Metab. 100(1):29-36. (2010)
Kawamura A, Tumber A, Rose NR, King ON, Daniel M, Oppermann U, Heightman TD, Schofield C. Development of homogeneous luminescence assays for histone demethylase catalysis and binding. Anal Biochem. Epub ahead of print (2010)
Cyr TD, She YM, Xu X, Yakunin AF, Dhe-Paganon S, Standing K, Donald LJ, Lee DC, Jia Z. Mass Spectrometry Following Mild Enzymatic Digestion Reveals Phosphorylation of Recombinant Proteins in Escherichia coli Through Mechanisms Involving Direct Nucleotide Binding. J Proteome Res. Epub ahead of print (2010)
Ramos ML, Prudent R, Moucadel V, Sautel C, Barette C, Lafanechère L, Mouawad L, Grierson D, Schmidt F, Florent JC, Filippakopoulos P, Bullock AN, Knapp S, Reiser JB, Cochet C. New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights. FASEB J. Epub ahead of print (2010)
Strushkevich N, Usanov SA, Park HW. Structural Basis of Human CYP51 Inhibition by Antifungal Azoles. J Mol Biol. 397(4):1067-78. (2010)
Hliscs M, Sattler J, Tempel W, Artz JD, Dong A, Hui R, Matuschewski K, Schuler H. Structure and function of a G-actin sequestering protein with a vital role in malaria oocyst development inside the mosquito vector. J Biol Chem. 285(15):11572-83. (2010)
Zhao R, Leung E, Grüner S, Schapira M, Houry WA. Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity. PLoS One. 5(4):e9934. (2010)
Frearson JA, Brand S, McElroy SP, Cleghorn LA, Smid O, Stojanovski L, Price HP, Guther ML, Torrie LS, Robinson DA, Hallyburton I, Mpamhanga CP, Brannigan JA, Wilkinson AJ, Hodgkinson M, Hui R, Qiu W, Raimi OG, van Aalten DM, Brenk R, Gilbert IH, Read KD, Fairlamb AH, Ferguson MA, Smith DF, Wyatt PG. N-myristoyltransferase inhibitors as new leads to treat sleeping sickness. Nature. 464(7289):728-32. (2010)
Pershad K, Pavlovic JD, Gräslund S, Nilsson P, Colwill K, Karatt-Vellatt A, Schofield DJ, Dyson MR, Pawson T, Kay BK, McCafferty J. Generating a panel of highly specific antibodies to 20 human SH2 domains by phage display. Protein Eng Des Sel. 23(4):279-88. (2010)
Elkins JM, Gileadi C, Shrestha L, Phillips C, Wang J, Muniz J, Doyle DA. Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms. Protein Sci. 19(4):731-41. (2010)
Hottiger MO, Hassa PO, Lüscher B, Schüler H, Koch-Nolte F. Toward a unified nomenclature for mammalian ADP-ribosyltransferases. Trends Biochem Sci. 35(4):208-19. (2010)
Campagna-Slater V, Arrowsmith AG, Zhao Y, Schapira M. Pharmacophore Screening of the Protein Data Bank for Specific Binding Site Chemistry. J Chem Inf Model. 50(3):358-67. (2010)
Xu GW, Ali M, Wood TE, Wong D, Maclean N, Wang X, Gronda M, Skrtic M, Li X, Hurren R, Mao X, Venkatesan M, Beheshti Zavareh R, Ketela T, Reed JC, Rose D, Moffat J, Batey RA, Dhe-Paganon S, Schimmer AD. The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood. 115(11):2251-9. (2010)
Loseva O, Jemth AS, Bryant HE, Schuler H, Lehtio L, Karlberg T, Helleday T. Poly(ADP-ribose) polymerase-3 (PARP-3) is a mono-ADP ribosylase that activates PARP-1 in absence of DNA. J Biol Chem. 285(11):8054-60. (2010)
Avvakumov GV, Cherkasov A, Muller YA, Hammond GL. Structural analyses of sex hormone-binding globulin reveal novel ligands and function. Mol Cell Endocrinol. 316(1):13-23 (2010)
Fedorov O, Müller S, Knapp S. The (un)targeted cancer kinome. Nat Chem Biol. 6(3):166-169. (2010)
Müller S, Weigelt J. Open-access public-private partnerships to enable drug discovery - New approaches. Idrugs 13(3):175-80. (2010)
Eswaran J, Knapp S. Insights into protein kinase regulation and inhibition by large scale structural comparison Biochim Biophys Acta. 1804(3):429-432 (2010)
Senisterra GA, Ghanei H, Khutoreskaya G, Dobrovetsky E, Edwards AM, Privé GG, Vedadi M. Assessing the Stability of Membrane Proteins to Detect Ligand Binding Using Differential Static Light Scattering. J Biomol Screen. 15(3):314-20. (2010)
Rose NR, Woon EC, Kingham GL, King ON, Mecinovi? J, Clifton IJ, Ng SS, Talib-Hardy J, Oppermann U, McDonough MA, Schofield CJ. Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches. J Med Chem. 53(4):1810-8. (2010)
Yue WW, Hozjan V, Ge W, Loenarz C, Cooper CD, Schofield CJ, Kavanagh KL, Oppermann U, McDonough MA. Crystal structure of the PHF8 Jumonji domain, an N(epsilon)-methyl lysine demethylase. FEBS Lett. 584(4):825-30 (2010)
Karlberg T, Hammarstro?m M, Schu?tz P, Svensson L, Schu?ler H. Crystal Structure of the Catalytic Domain of Human PARP2 in Complex with PARP Inhibitor ABT-888. Biochemistry. 49(6):1056-8 (2010)
Boxer MB, Jiang JK, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. J Med Chem. 53(3):1048-55. (2010)
Rauschenberger K, Schöler K, Sass JO, Sauer S, Djuric Z, Rumig C, Wolf NI, Okun JG, Kölker S, Schwarz H, Fischer C, Grziwa B, Runz H, Nümann A, Shafqat N, Kavanagh KL, Hämmerling G, Wanders RJ, Shield JP, Wendel U, Stern D, Nawroth P, Hoffmann GF, Bartram CR, Arnold B, Bierhaus A, Oppermann U, Steinbeisser H, Zschocke J. A non-enzymatic function of 17beta-hydroxysteroid dehydrogenase type 10 is required for mitochondrial integrity and cell survival. EMBO Mol Med. 2(2):51-62. (2010)
Sakurai M, Rose NR, Schultz L, Quinn AM, Jadhav A, Ng SS, Oppermann U, Schofield CJ, Simeonov A. A miniaturized screen for inhibitors of Jumonji histone demethylases. Mol Biosyst. 6(2):357-64. (2010)
Littler DR, Walker JR, Davis T, Wybenga-Groot LE, Finerty PJ Jr, Newman E, Mackenzie F, Dhe-Paganon S. A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation. Acta Crystallogr Sect F Struct Biol Cryst Commun. 66(Pt 2):143-51 (2010)
Ravulapalli R, Campbell RL, Gauthier SY, Dhe-Paganon S, Davies PL. Distinguishing between calpain heterodimerization and homodimerization. FEBS J. 276(4):973-82. (2010)
Quinn AM, Bedford MT, Espejo A, Spannhoff A, Austin CP, Oppermann U, Simeonov A. A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics. Nucleic Acids Res. 38(2):e11 (2010)
Loenarz C, Ge W, Coleman ML, Rose NR, Cooper CD, Klose RJ, Ratcliffe PJ, Schofield CJ. PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an N{varepsilon}-dimethyl lysine demethylase. Hum Mol Genet. 19(2):217-22 (2010)
Wisniewska M, Karlberg T, Lehtiö L, Johansson I, Kotenyova T, Moche M, Schüler H. Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78. PLoS One. 5(1):e8625. (2010)
Wu H, Min J, Lunin VV, Antoshenko T, Dombrovski L, Zeng H, Allali-Hassani A, Campagna-Slater V, Vedadi M, Arrowsmith CH, Plotnikov AN, Schapira M. Structural biology of human H3K9 methyltransferases. PLoS One. 5(1):e8570. (2010)
Natallia Strushkevich, Sergey A. Usanov, and Hee-Won Park. Vitamin D: Nutrition, Side Effects and Supplements Human Vitamin D 25-Hydroxylase: Structure and Function. (2010)
Schapira M Structural genomics, its application in Chemistry, Biology, Medicine, and Drug Discovery Burger's Medicinal Chemistry, Drug Discovery and Development, 2010   (2010)
Qiu L, Pashkova N, Walker JR, Winistorfer S, Allali-Hassani A, Akutsu M, Piper R, Dhe-Paganon S. Structure and function of the PLAA/Doa1/Ufd3-p97/Cdc48 complex. J Biol Chem. 285(1):365-72 (2010)
Wigle TJ, Herold JM, Senisterra GA, Vedadi M, Kireev DB, Arrowsmith CH, Frye SV, Janzen WP. Screening for Inhibitors of Low-Affinity Epigenetic Peptide-Protein Interactions: An AlphaScreenTM-Based Assay for Antagonists of Methyl-Lysine Binding Proteins. J Biomol Screen. 5(1):62-71 (2010)
Liu F, Chen X, Allali-Hassani A, Quinn AM, Wasney GA, Dong A, Barsyte D, Kozieradzki I, Senisterra G, Chau I, Siarheyeva A, Kireev DB, Jadhav A, Herold JM, Frye SV, Arrowsmith CH, Brown PJ, Simeonov A, Vedadi M, Jin J. Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a. J Med Chem. 52(24):7950-3. (2009)
Tong Y, Hota PK, Penachioni JY, Hamaneh MB, Kim S, Alviani RS, Shen L, He H, Tempel W, Tamagnone L, Park HW, Buck M. Structure and function of the intracellular region of the plexin-b1 transmembrane receptor. J Biol Chem. 284(51):35962-72. (2009)
Chen C, Jin J, James DA, Adams-Cioaba MA, Park JG, Guo Y, Tenaglia E, Xu C, Gish G, Min J, Pawson T. Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi. Proc Natl Acad Sci U S A 106(48):20336-41. (2009)
Ganter M, Schüler H, Matuschewski K. Vital role for the Plasmodium actin capping protein (CP) beta-subunit in motility of malaria sporozoites. Mol Microbiol. 74(6):1356-67 (2009)
Filippakopoulos P, Müller S, Knapp S. SH2 domains: modulators of nonreceptor tyrosine kinase activity Curr Opin Struct Biol. 19(6):643-9. (2009)
Eswaran J, Patnaik D, Filippakopoulos P, Wang F, Stein RL, Murray JW, Higgins JM, Knapp S. Structure and functional characterization of the atypical human kinase haspin. Proc Natl Acad Sci U S A. 106(48):20198-203 (2009)
Coutandin D, Löhr F, Niesen FH, Ikeya T, Weber TA, Schäfer B, Zielonka EM, Bullock AN, Yang A, Güntert P, Knapp S, McKeon F, Ou HD, Dötsch V. Conformational stability and activity of p73 require a second helix in the tetramerization domain. Cell Death Differ. 16(12):1582-9 (2009)
Bezsonova I, Walker JR, Bacik JP, Duan S, Dhe-Paganon S, Arrowsmith CH. Ring1B Contains a Ubiquitin-Like Docking Module for Interaction with Cbx Proteins. Biochemistry. 48(44):10542-8 (2009)
Herman MD, Moche M, Flodin S, Welin M, Trésaugues L, Johansson I, Nilsson M, Nordlund P, Nyman T. Structures of BIR domains from human NAIP and cIAP2. Acta Crystallogr Sect F Struct Biol Cryst Commun. 65(Pt 11):1091-6. (2009)
Harvey D, Pointon JJ, Evans DM, Karaderi T, Farrar C, Appleton LH, Sturrock RD, Stone MA, Oppermann U, Brown MA, Wordsworth BP. Investigating the genetic association between ERAP1 and ankylosing spondylitis. Hum Mol Genet. 18(21):4204-12. (2009)
Allali-Hassani A, Wasney GA, Chau I, Hong BS, Senisterra G, Loppnau P, Shi Z, Moult J, Edwards AM, Arrowsmith CH, Park HW, Schapira M, Vedadi M. A survey of proteins encoded by non-synonymous SNPs reveals a significant fraction with altered stability and activity. Biochem J. 424(1):15-26 (2009)
Raush E, Totrov M, Marsden BD, Abagyan R. A new method for publishing three-dimensional content. PLoS One. 4(10):e7394. (2009)
Lee WH, Atienza-Herrero J, Abagyan R, Marsden BD. SGC - Structural Biology and Human Health: A New Approach to Publishing Structural Biology Results PLoS One. 4(10):e7675. (2009)
Karlberg T, van den Berg S, Hammarström M, Sagemark J, Johansson I, Holmberg-Schiavone L, Schüler H. Crystal structure of the ATPase domain of the human AAA+ protein paraplegin/SPG7. PLoS One. 4(10):e6975. (2009)
Pilka ES, Niesen FH, Lee WH, El-Hawari Y, Dunford JE, Kochan G, Wsol V, Martin HJ, Maser E, Oppermann U. Structural basis for substrate specificity in human monomeric carbonyl reductases. PLoS One. 4(10):e7113. (2009)
Tong Y, Tempel W, Nedyalkova L, Mackenzie F, Park HW. Crystal structure of the N-acetylmannosamine kinase domain of GNE. PLoS One. 4(10):e7165. (2009)
Bullock AN, Russo S, Amos A, Pagano N, Bregman H, Debreczeni JE, Lee WH, von Delft F, Meggers E, Knapp S. Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor. PLoS One. 4(10):e7112. (2009)
Eryilmaz J, Pan P, Amaya MF, Allali-Hassani A, Dong A, Adams-Cioaba MA, Mackenzie F, Vedadi M, Min J. Structural studies of a four-MBT repeat protein MBTD1. PLoS One. 4(10):e7274. (2009)
Alag R, Bharatham N, Dong A, Hills T, Harikishore A, Widjaja AA, Shochat SG, Hui R, Yoon HS. Crystallographic structure of the tetratricopeptide repeat domain of Plasmodium falciparum FKBP35 and its molecular interaction with Hsp90 C-terminal pentapeptide. Protein Sci. 18(10):2115-24. (2009)
Thorsell AG, Persson C, Gräslund S, Hammarström M, Busam RD, Hallberg BM. Crystal structure of human diphosphoinositol phosphatase 1. Proteins. 77(1):242-6 (2009)
Weigelt J. The case for open-access chemical biology. A strategy for pre-competitive medicinal chemistry to promote drug discovery. EMBO Rep 10(9):941-5 (2009)
Campagna-Slater V, Schapira M. Evaluation of Virtual Screening as a Tool for Chemical Genetic Applications. J Chem Inf Model. 49(9):2082-91. (2009)
Wu H, Min J, Antoshenko T, Plotnikov AN. Crystal structures of human CDY proteins reveal a crotonase-like fold. Proteins. 76(4):1054-61. (2009)
Müller S, Knapp S. Out of the box binding determines specificity of SH2 domain interaction. Structure. 17(8):1040-1 (2009)
Choi Y, Syeda F, Walker JR, Finerty PJ Jr, Cuerrier D, Wojciechowski A, Liu Q, Dhe-Paganon S, Gray NS. Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 19(15):4467-70. (2009)
Davis TL, Walker JR, Allali-Hassani A, Parker SA, Turk BE, Dhe-Paganon S. Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases. FEBS J. 276(16):4395-404. (2009)
Sibley LD, Qiu W, Fentress S, Taylor SJ, Khan A, Hui R. Forward genetics in Toxoplasma gondii reveals a family of rhoptry kinases that mediates pathogenesis. Eukaryot Cell 8(8):1085-93 (2009)
Picaud SS, Muniz JR, Kramm A, Pilka ES, Kochan G, Oppermann U, Yue WW. Crystal structure of human carbonic anhydrase-related protein VIII reveals the basis for catalytic silencing. Proteins. 76(2):507-11. (2009)
Kimple AJ, Soundararajan M, Hutsell SQ, Roos AK, Urban DJ, Setola V, Temple BR, Roth BL, Knapp S, Willard FS, Siderovski DP. Structural determinants of G-protein {alpha} subunit selectivity by regulator of G-protein signaling 2 (RGS2). J Biol Chem. 284(29):19402-11 (2009)
Powlowski J, Mahajan S, Schapira M, Master ER. Substrate recognition and hydrolysis by a fungal xyloglucan-specific family 12 hydrolase. Carbohydr Res. 344(10):1175-9. (2009)
Crowther GJ, Napuli AJ, Thomas AP, Chung DJ, Kovzun KV, Leibly DJ, Castaneda LJ, Bhandari J, Damman CJ, Hui R, Hol WG, Buckner FS, Verlinde CL, Zhang Z, Fan E, van Voorhis WC. Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands. J Biomol Screen. 14(6):700-7. (2009)
Edwards AM, Bountra C, Kerr DJ, Willson TM. Open access chemical and clinical probes to support drug discovery. Nat Chem Biol. 5(7):436-40. (2009)
Bunkoczi G, Misquitta S, Wu X, Lee WH, Rojkova A, Kochan G, Kavanagh KL, Oppermann U, Smith S. Structural basis for different specificities of acyltransferases associated with the human cytosolic and mitochondrial fatty acid synthases. Chem Biol. 16(6):667-75 (2009)
Porté S, Valencia E, Yakovtseva EA, Borràs E, Shafqat N, Debreczeny JE, Pike AC, Oppermann U, Farrés J, Fita I, Parés X. Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase pig3. J Biol Chem. 284(25):17194-205 (2009)
Eswaran J, Soundararajan M, Knapp S. Targeting group II PAKs in cancer and metastasis. Cancer Metastasis Rev. 28(1-2):209-17 (2009)
Magnusdottir A, Johansson I, Dahlgren LG, Nordlund P, Berglund H. Enabling IMAC purification of low abundance recombinant proteins from E. coli lysates. Nat Methods. 6(7):477-8 (2009)
Tong Y, Park I, Hong BS, Nedyalkova L, Tempel W, Park HW. Crystal structure of human eIF5A1: insight into functional similarity of human eIF5A1 and eIF5A2. Proteins. 75(4):1040-5 (2009)
Edwards A. Large-scale structural biology of the human proteome. Annu Rev Biochem. 78:541-68. (2009)
Kochan G, Pilka ES, von Delft F, Oppermann U, Yue WW. Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A. J Mol Biol. 388(5):997-1008 (2009)
Lehtiö L, Jemth AS, Collins R, Loseva O, Johansson A, Markova N, Hammarström M, Flores A, Holmberg-Schiavone L, Weigelt J, Helleday T, Schüler H, Karlberg T. Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3. J Med Chem. 52(9):3108-11 (2009)
Huck K, Feyen O, Niehues T, Rüschendorf F, Hübner N, Laws HJ, Telieps T, Knapp S, Wacker HH, Meindl A, Jumaa H, Borkhardt A. Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation. J Clin Invest. 119(5):1350-8. (2009)
Collins R, Karlberg T, Lehtiö L, Schütz P, van den Berg S, Dahlgren LG, Hammarström M, Weigelt J, Schüler H. The DEXD/H-box RNA Helicase DDX19 Is Regulated by an {alpha}-Helical Switch. J Biol Chem. 284(16):10296-300 (2009)
Collins R, Karlberg T, Lehtiö L, Schütz P, van den Berg S, Dahlgren LG, Hammarström M, Weigelt J, Schüler H. The DExD/H-box RNA helicase DDX19 is regulated by an alpha -helical switch. J Biol Chem. 284(16):10296-300 (2009)
Min T, Vedadi M, Watson DC, Wasney GA, Munger C, Cygler M, Matte A, Young NM. Specificity of Campylobacter jejuni adhesin PEB3 for phosphates and structural differences among its ligand complexes. Biochemistry. 48(14):3057-67 (2009)
Qiu W, Wernimont A, Tang K, Taylor S, Lunin V, Schapira M, Fentress S, Hui R, Sibley LD. Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondii. EMBO J. 28(7):969-79 (2009)
Wernimont A, Edwards A. In situ proteolysis to generate crystals for structure determination: an update. PLoS One. 4(4):e5094 (2009)
Gingras MC, Zhang YL, Kharitidi D, Barr AJ, Knapp S, Tremblay ML, Pause A. HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain. PLoS ONE. 4(4):e5105 (2009)
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Bullock AN, Rodriguez MC, Debreczeni JE, Songyang Z, Knapp S. Structure of the SOCS4-ElonginB/C Complex Reveals a Distinct SOCS Box Interface and the Molecular Basis for SOCS-Dependent EGFR Degradation. Structure 15(11):1493-504 (2007)
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Dufe VT, Qiu W, Müller IB, Hui R, Walter RD, Al-Karadaghi S. Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO. J Mol Biol. 373(1):167-77. (2007)
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Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C. Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD(+). PLoS Biol. 5(10):e263 (2007)
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Rellos P, Ivins FJ, Baxter JE, Pike A, Nott TJ, Parkinson DM, Das S, Howell S, Federov O, Shen QY, Fry AM, Knapp S, Smerdon SJ. Structure and regulation of the human NEK2 centrosomal kinase. J Biol Chem. 282(9):6833-6842 (2007)
Schuetz A, Min J, Antoshenko T, Wang CL, Allali-Hassani A, Dong A, Loppnau P, Vedadi M, Bochkarev A, Sternglanz R, Plotnikov AN. Structural Basis of Inhibition of the Human NAD(+)-Dependent Deacetylase SIRT5 by Suramin. Structure. 15(3):377-89 (2007)
Wu X , Lukacik P, Kavanagh KL, Oppermann U SDR-type human hydroxysteroid dehydrogenases involved in steroid hormone activation. Mol Cell Endocrinol 265-266:71-6 (2007)
Eswaran J, Lee WH, Debreczeni JE, Filippakopoulos P, Turnbull A, Fedorov O, Deacon SW, Peterson JR and Knapp S. Crystal structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs. Structure 201-13 (2007)
Davis TL, Walker JR, Finerty PJ Jr, Mackenzie F, Newman EM, Dhe-Paganon S. The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. J Mol Biol 366(1):216-29 (2007)
Stenmark P, Kursula P, Flodin S, Graslund S, Landry R, Nordlund P, Schuler H. Crystal structure of Human Inosine Triphosphatase: Substrate Binding and Implication of the ITPA Deficiency Mutation P32T Journal of Biological Chemistry 282(5):3182-7 (2007)
Johansson C , Kavanagh KL, Gileadi O , Oppermann U Reversible Sequestration of Active Site cysteines in a 2Fe2S-bridged dimer provides a mechanism for mitochondrial glutaredoxin regulation. J Biol Chem 282(5):3077-82 (2007)
Soundararajan M, Yang X, Elkins JM, Sobott F and Doyle DA The Centaurin Gamma-1 GTPase-like domain functions as an NTPase. Biochem J. 401(3):679-88 (2007)
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Najmanovich RJ, Allali-Hassani A, Morris RJ, Dombrovski L, Pan PW, Vedadi M, Plotnikov AN, Arrowsmith C, Edwards AM and Thornton JM Analysis of binding site similarity, small molecule similarity and experimental binding profiles in the human cytosolic. ECCB 23(2):e104-9 (2007)
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Magnusdottir A, Stenmark P, Flodin S, Nyman T, Hammarstrom M, Ehn M, Bakali H MA, Berglund H, Nordlund P. The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions. J Biol Chem 281(32):22434-8 (2006)
Kavanagh KL, Dunford JE, Bunkoczi G, Russell GG and Oppermann U. The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding. J Biol Chem 281(31):22004-1 (2006)
Kursula P, Flodin S, Ehn M, Hammarstrom M, Schuler H, Nordlund P, Stenmark P. Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy Acta Crystallograph Sect F Struct Biol Cryst Commun 62(7):613-7 (2006)
Marsden BD, Sundstrom M and Knapp S. High Throughput Structural Characterization of Therapeutic Protein Targets. Expert Opinion in Drug Discovery (EODD) 1(2): 123-136 (2006)
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Bullock A.N, Debreczeni J.E, Edwards A.M, Sundström M and Knapp S Crystal Structure of the SOCS2-ElonginC-ElonginB Complex Defines a Prototypical SOCS-Box Ubiquitin Ligase. PNAS 103(20):7637-42 (2006)
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Guo K, Lukacik P, Papagrigoriou E, Meier M, Lee WH, Adamski J, Oppermann U Characterization of Human DHRS6, an Orphan SDR Enzyme: a Novel, Cytosolic Type 2 R-beta-hydroxybutyrate Dehydrogenase J Biol Chem., 281(15):10291-7 (2006)
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Lukacik P, Kavanagh K.L and Oppermann U Structure and function of human 17beta-hydroxysteroid dehydrogenases. Mol Cell Endocrinology 248(1-2):61-71 (2006)
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Abagyan R, Lee WH, Raush E, Budagyan L, Totrov M, Sundstrom M and Marsden B. Disseminating structural genomics data to the public: from a data dump to an animated story. TIBS 31(2):76-8 . (2006)
Domene C, Vemparala S, Klein ML, Venien-Bryan C, Doyle DA. Role of aromatic localization in the gating process of a potassium channel. Biophys. J 90(1):L01-3 (2006)
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Park HW Structure Determination of the Motor Domain of Yeast Kinesin Kar3 by X-ray Crystallography In Methods of Molecular Biology (Walker, J.M., ed) (2006)
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McDonough M.A, Kavanagh K, Searls T, Butler D, Oppermann U and Schofield C.J Structure of Human Phytanoyl-CoA 2-Hydroxylase Identifies Molecular Mechanisms of Refsum Disease J. Biol. Chem 280(49) 41101-10 (2005)
Bullock A.N, Debreczeni J.E, Fedorov O.Y, Nelson A, Marsden B.D, Knapp S. Structural basis of inhibitor specificity of the human proto-oncogene proviral insertion site in Moloney Murine Leukemia Virus (PIM-1) kinase. Journal of Medicinal Chemistry 48(24):7604-14 (2005)
Ismail SA, Park HW Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase Acta Crystallogr D Biol Crystallogr 61:1508-1513 (2005)
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