Publications

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Displaying 1 - 50 of 1232

2017

April 2017

The RNF168 paralog RNF169 defines a new class of ubiquitylated-histone reader involved in the response to DNA damage.
Kitevski-LeBlanc J, Fradet-Turcotte A, Kukic P, Wilson MD, Portella G, Yuwen T, Panier S, Duan S, Canny MD, van Ingen H, Arrowsmith CH, Rubinstein JL, Vendruscolo M, Durocher D, Kay LE
Elife 6: . doi: 10.7554/eLife.23872
Publication date: April 13, 2017
PMID: 28406400
Molecular basis for the methylation specificity of ATXR5 for histone H3.
Bergamin E, Sarvan S, Malette J, Eram MS, Yeung S, Mongeon V, Joshi M, Brunzelle JS, Michaels SD, Blais A, Vedadi M, Couture JF
Nucleic Acids Res. . doi: 10.1093/nar/gkx224
Publication date: April 5, 2017
PMID: 28383693

March 2017

Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation.
Gao Y, Zhang Q, Lang Y, Liu Y, Dong X, Chen Z, Tian W, Tang J, Wu W, Tong Y, Chen Z
J Mol Cell Biol . doi: 10.1093/jmcb/mjx010
Publication date: March 20, 2017
PMID: 28369529
Antibody Validation by Immunoprecipitation Followed by Mass Spectrometry Analysis.
Persson H, Preger C, Marcon E, Lengqvist J, Gräslund S
Methods Mol. Biol. 1575:175-187 . doi: 10.1007/978-1-4939-6857-2_10
Publication date: March 4, 2017
PMID: 28255880

February 2017

Peptide recognition by HP1 chromoshadow domains revisited: plasticity in the pseudosymmetric histone binding site of human HP1.
Liu Y, Qin S, Lei M, Tempel W, Zhang Y, Loppnau P, Li Y, Min J
J. Biol. Chem. . doi: 10.1074/jbc.M116.768374
Publication date: February 21, 2017
PMID: 28223359
Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2.
Barnash KD, The J, Norris-Drouin JL, Cholensky SH, Worley BM, Li F, Stuckey JI, Brown PJ, Vedadi M, Arrowsmith CH, Frye SV, James LI
ACS Comb Sci . doi: 10.1021/acscombsci.6b00174
Publication date: February 6, 2017
PMID: 28165227
Targeting human SET1/MLL family of proteins.
Vedadi M, Blazer L, Eram MS, Barsyte-Lovejoy D, Arrowsmith CH, Hajian T
Protein Sci. . doi: 10.1002/pro.3129
Publication date: February 4, 2017
PMID: 28160335

January 2017

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.
He Y, Selvaraju S, Curtin ML, Jakob CG, Zhu H, Comess KM, Shaw B, The J, Lima-Fernandes E, Szewczyk MM, Cheng D, Klinge KL, Li HQ, Pliushchev M, Algire MA, Maag D, Guo J, Dietrich J, Panchal SC, Petros AM, Sweis RF, Torrent M, Bigelow LJ, Senisterra G, Li F, Kennedy S, Wu Q, Osterling DJ, Lindley DJ, Gao W, Galasinski S, Barsyte-Lovejoy D, Vedadi M, Buchanan FG, Arrowsmith CH, Chiang GG, Sun C, Pappano WN
Nat. Chem. Biol. . doi: 10.1038/nchembio.2306
Publication date: January 30, 2017
PMID: 28135237
Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.
Xiong Y, Li F, Babault N, Dong A, Zeng H, Wu H, Chen X, Arrowsmith CH, Brown PJ, Liu J, Vedadi M, Jin J
J. Med. Chem. . doi: 10.1021/acs.jmedchem.6b01645
Publication date: January 30, 2017
PMID: 28135087
Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor.
Osman KT, Ye J, Shi Z, Toker C, Lovato D, Jumani RS, Zuercher W, Huston CD, Edwards AM, Lautens M, Santhakumar V, Hui R
Bioorg. Med. Chem. . doi: 10.1016/j.bmc.2017.01.036
Publication date: January 24, 2017
PMID: 28162900
The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.
Bromberg KD, Mitchell TR, Upadhyay AK, Jakob CG, Jhala MA, Comess KM, Lasko LM, Li C, Tuzon CT, Dai Y, Li F, Eram MS, Nuber A, Soni NB, Manaves V, Algire MA, Sweis RF, Torrent M, Schotta G, Sun C, Michaelides MR, Shoemaker AR, Arrowsmith CH, Brown PJ, Santhakumar V, Martin A, Rice JC, Chiang GG, Vedadi M, Barsyte-Lovejoy D, Pappano WN
Nat. Chem. Biol. . doi: 10.1038/nchembio.2282
Publication date: January 23, 2017
PMID: 28114273
Target engagement: Shining a light.
Huber KV;
Nature Chemical Biology 13:133-134 . doi: 10.1038/nchembio.2295
Publication date: January 19, 2017
PMID: 28103226
Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.
Newman, JA; Aitkenhead, H; Savitsky, P; Gileadi, O;
Nucleic Acids Research :- . doi: 10.1093/nar/gkw1362
Publication date: January 18, 2017
PMID: 28100692
Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2.
Wilkes, M; Madej, MG; Kreuter, L; Rhinow, D; Heinz, V; De Sanctis, S; Ruppel, S; Richter, RM; Joos, F; Grieben, M; Pike, AC; Huiskonen, JT; Carpenter, EP; Kühlbrandt, W; Witzgall, R; Ziegler, C;
Nature Structural and Molecular Biology 24:123-130 . doi: 10.1038/nsmb.3357
Publication date: January 16, 2017
PMID: 28092368
Chemical Probes Targeting Epigenetic Proteins: Applications Beyond Oncology.
Ackloo S, Brown PJ, Müller S
Epigenetics 0 . doi: 10.1080/15592294.2017.1279371
Publication date: January 12, 2017
PMID: 28080202
Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies.
Igoe, N; Bayle, ED; Fedorov, O; Tallant, C; Savitsky, P; Rogers, C; Owen, DR; Deb, G; Somervaille, TC; Andrews, DM; Jones, N; Cheasty, A; Ryder, H; Brennan, PE; Müller, S; Knapp, S; Fish, PV;
Journal of Medicinal Chemistry 60:668-680 . doi: 10.1021/acs.jmedchem.6b01583
Publication date: January 9, 2017
PMID: 28068087
Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma.
Veschi V, Liu Z, Voss TC, Ozbun L, Gryder B, Yan C, Hu Y, Ma A, Jin J, Mazur SJ, Lam N, Souza BK, Giannini G, Hager GL, Arrowsmith CH, Khan J, Appella E, Thiele CJ
Cancer Cell 31(1):50-63 . doi: 10.1016/j.ccell.2016.12.002
Publication date: January 9, 2017
PMID: 28073004
Functions of bromodomain-containing proteins and their roles in homeostasis and cancer.
Fujisawa, T; Filippakopoulos, P;
Nature Reviews: Molecular Cell Biology :- . doi: 10.1038/nrm.2016.143
Publication date: January 5, 2017
PMID: 28053347
Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16.
Dixon-Clarke, SE; Shehata, SN; Krojer, T; Sharpe, TD; von Delft, F; Sakamoto, K; Bullock, AN;
Biochemical Journal :- . doi: 10.1042/BCJ20160941
Publication date: January 5, 2017
PMID: 28057719
Combinatorial Drug Screening Identifies Ewing Sarcoma-specific Sensitivities.
Radic-Sarikas, B; Tsafou, KP; Emdal, KB; Papamarkou, T; Huber, KV; Mutz, C; Toretsky, JA; Bennett, KL; Olsen, JV; Brunak, S; Kovar, H; Superti-Furga, G;
Molecular Cancer Therapeutics 16:88-101 . doi: 10.1158/1535-7163.MCT-16-0235
Publication date: January 1, 2017
PMID: 28062706
2016

December 2016

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).
Grieben, M; Pike, AC; Shintre, CA; Venturi, E; El-Ajouz, S; Tessitore, A; Shrestha, L; Mukhopadhyay, S; Mahajan, P; Chalk, R; Burgess-Brown, NA; Sitsapesan, R; Huiskonen, JT; Carpenter, EP;
Nature Structural and Molecular Biology 24:114-122 . doi: 10.1038/nsmb.3343
Publication date: December 19, 2016
PMID: 27991905
CBP/p300 Bromodomains Regulate Amyloid-like Protein Aggregation upon Aberrant Lysine Acetylation.
Olzscha, H; Fedorov, O; Kessler, BM; Knapp, S; La Thangue, NB;
Cell chemical biology 24:9-23 . doi: 10.1016/j.chembiol.2016.11.009
Publication date: December 10, 2016
PMID: 27989401
Early-life antibiotic treatment enhances the pathogenicity of CD4+ T cells during intestinal inflammation.
Scheer S, Medina TS, Murison A, Taves MD, Antignano F, Chenery A, Soma KK, Perona-Wright G, Lupien M, Arrowsmith CH, De Carvalho DD, Zaph C
J. Leukoc. Biol. . doi: 10.1189/jlb.3MA0716-334RR
Publication date: December 29, 2016
PMID: 28034915
Discovery of a PCAF Bromodomain Chemical Probe.
Moustakim M, Clark PG, Trulli L, Fuentes de Arriba AL, Ehebauer MT, Chaikuad A, Murphy EJ, Mendez-Johnson J, Daniels D, Hou CD, Lin YH, Walker JR, Hui R, Yang H, Dorrell L, Rogers CM, Monteiro OP, Fedorov O, Huber KV, Knapp S, Heer J, Dixon DJ, Brennan PE
Angew. Chem. Int. Ed. Engl. . doi: 10.1002/anie.201610816
Publication date: December 14, 2016
PMID: 27966810
Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.
Torchia J, Golbourn B, Feng S, Ho KC, Sin-Chan P, Vasiljevic A, Norman JD, Guilhamon P, Garzia L, Agamez NR, Lu M, Chan TS, Picard D, de Antonellis P, Khuong-Quang DA, Planello AC, Zeller C, Barsyte-Lovejoy D, Lafay-Cousin L, Letourneau L, Bourgey M, Yu M, Gendoo DM, Dzamba M, Barszczyk M, Medina T, Riemenschneider AN, Morrissy AS, Ra YS, Ramaswamy V, Remke M, Dunham CP, Yip S, Ng HK, Lu JQ, Mehta V, Albrecht S, Pimentel J, Chan JA, Somers GR, Faria CC, Roque L, Fouladi M, Hoffman LM, Moore AS, Wang Y, Choi SA, Hansford JR, Catchpoole D, Birks DK, Foreman NK, Strother D, Klekner A, Bognár L, Garami M, Hauser P, Hortobágyi T, Wilson B, Hukin J, Carret AS, Van Meter TE, Hwang EI, Gajjar A, Chiou SH, Nakamura H, Toledano H, Fried I, Fults D, Wataya T, Fryer C, Eisenstat DD, Scheinemann K, Fleming AJ, Johnston DL, Michaud J, Zelcer S, Hammond R, Afzal S, Ramsay DA, Sirachainan N, Hongeng S, Larbcharoensub N, Grundy RG, Lulla RR, Fangusaro JR, Druker H, Bartels U, Grant R, Malkin D, McGlade CJ, Nicolaides T, Tihan T, Phillips J, Majewski J, Montpetit A, Bourque G, Bader GD, Reddy AT, Gillespie GY, Warmuth-Metz M, Rutkowski S, Tabori U, Lupien M, Brudno M, Schüller U, Pietsch T, Judkins AR, Hawkins CE, Bouffet E, Kim SK, Dirks PB, Taylor MD, Erdreich-Epstein A, Arrowsmith CH, De Carvalho DD, Rutka JT, Jabado N, Huang A
Cancer Cell 30(6):891-908 . doi: 10.1016/j.ccell.2016.11.003
Publication date: December 12, 2016
PMID: 27960086
Functional and structural characterization of a novel putative cysteine protease cell wall-modifying multi-domain enzyme selected from a microbial metagenome.
Faheem, M; Martins-de-Sa, D; Vidal, JF; Álvares, AC; Brandão-Neto, J; Bird, LE; Tully, MD; von Delft, F; Souto, BM; Quirino, BF; Freitas, SM; Barbosa, JA;
Scientific Reports 6:38031- . doi: 10.1038/srep38031
Publication date: December 9, 2016
PMID: 27934875
Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8.
Judge RA, Zhu H, Upadhyay AK, Bodelle PM, Hutchins CW, Torrent M, Marin VL, Yu W, Vedadi M, Li F, Brown PJ, Pappano WN, Sun C, Petros AM
ACS Med Chem Lett 7(12):1102-1106 . doi: 10.1021/acsmedchemlett.6b00303
Publication date: December 8, 2016
PMID: 27994746
Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin.
Savitsky P, Krojer T, Fujisawa T, Lambert JP, Picaud S, Wang CY, Shanle EK, Krajewski K, Friedrichsen H, Kanapin A, Goding C, Schapira M, Samsonova A, Strahl BD, Gingras AC, Filippakopoulos P
Cell Rep 17(10):2724-2737 . doi: 10.1016/j.celrep.2016.11.014
Publication date: December 6, 2016
PMID: 27926874
Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24.
Mehmood, S; Marcoux, J; Gault, J; Quigley, A; Michaelis, S; Young, SG; Carpenter, EP; Robinson, CV;
Nature Chemistry 8:1152-1158 . doi: 10.1038/nchem.2591
Publication date: December 1, 2016
PMID: 27874871
Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions.
Martins, R; Maier, J; Gorki, AD; Huber, KV; Sharif, O; Starkl, P; Saluzzo, S; Quattrone, F; Gawish, R; Lakovits, K; Aichinger, MC; Radic-Sarikas, B; Lardeau, CH; Hladik, A; Korosec, A; Brown, M; Vaahtomeri, K; Duggan, M; Kerjaschki, D; Esterbauer, H; Colinge, J; Eisenbarth, SC; Decker, T; Bennett, KL; Kubicek, S; Sixt, M; Superti-Furga, G; Knapp, S;
Nature Immunology 17:1361-1372 . doi: 10.1038/ni.3590
Publication date: December 1, 2016
PMID: 27798618

November 2016

Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity.
Li, J; Casteels, T; Frogne, T; Ingvorsen, C; Honoré, C; Courtney, M; Huber, KV; Schmitner, N; Kimmel, RA; Romanov, RA; Sturtzel, C; Lardeau, CH; Klughammer, J; Farlik, M; Sdelci, S; Vieira, A; Avolio, F; Briand, F; Baburin, I; Májek, P; Pauler, FM; Penz, T; Stukalov, A; Gridling, M; Parapatics, K; Barbieux, C; Berishvili, E; Spittler, A; Colinge, J; Bennett, KL; Hering, S; Sulpice, T; Bock, C; Distel, M; Harkany, T; Meyer, D; Superti-Furga, G; Collombat, P; Hecksher-Sørensen, J; Kubicek, S;
Cell 168:86-100.e15 . doi: 10.1016/j.cell.2016.11.010
Publication date: November 30, 2016
PMID: 27916275
Herpes simplex virus specific T cell response in a cohort with primary genital infection correlates inversely with frequency of subsequent recurrences. Sexually transmitted infections 2016
Franzen-Röhl E, Schepis D, Atterfelt F, Franck K, Wikström A, Liljeqvist JÅ, Bergström T, Aurelius E, Kärre K, Berg L, Gaines H.
BMJ Journals . doi: 10.1136/sextrans-2016-052811
Publication date: November 30, 2016
PMID:
Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair.
Vaz, B; Popovic, M; Newman, JA; Fielden, J; Aitkenhead, H; Halder, S; Singh, AN; Vendrell, I; Fischer, R; Torrecilla, I; Drobnitzky, N; Freire, R; Amor, DJ; Lockhart, PJ; Kessler, BM; McKenna, GW; Gileadi, O; Ramadan, K;
Molecular Cell 64:704-719 . doi: 10.1016/j.molcel.2016.09.032
Publication date: November 17, 2016
PMID: 27871366
Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.
Butler KV, Ma A, Yu W, Li F, Tempel W, Babault N, Pittella-Silva F, Shao J, Wang J, Luo M, Vedadi M, Brown PJ, Arrowsmith CH, Jin J
J. Med. Chem. . doi: 10.1021/acs.jmedchem.6b01244
Publication date: November 2, 2016
PMID: 27804297
Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly.
Xu C, Ishikawa H, Izumikawa K, Li L, He H, Nobe Y, Yamauchi Y, Shahjee HM, Wu XH, Yu YT, Isobe T, Takahashi N, Min J
Genes Dev. 30(21):2376-2390 . doi: 10.1101/gad.288340.116
Publication date: November 1, 2016
PMID: 27881600

September 2016

BRD4 localization to lineage-specific enhancers is associated with a distinct transcription factor repertoire.
Najafova, Z; Tirado-Magallanes, R; Subramaniam, M; Hossan, T; Schmidt, G; Nagarajan, S; Baumgart, SJ; Mishra, VK; Bedi, U; Hesse, E; Knapp, S; Hawse, JR; Johnsen, SA;
Nucleic Acids Research 45:127-141 . doi: 10.1093/nar/gkw826
Publication date: September 18, 2016
PMID: 27651452
Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.
Picaud, S; Leonards, K; Lambert, JP; Dovey, O; Wells, C; Fedorov, O; Monteiro, O; Fujisawa, T; Wang, CY; Lingard, H; Tallant, C; Nikbin, N; Guetzoyan, L; Ingham, R; Ley, SV; Brennan, P; Muller, S; Samsonova, A; Gingras, AC; Schwaller, J; Vassiliou, G; Knapp, S; Filippakopoulos, P;
Science Advances 2:e1600760- . doi: 10.1126/sciadv.1600760
Publication date: September 30, 2016
PMID: 27757418
Epigenetic blockade of neoplastic transformation by bromodomain and extra-terminal (BET) domain protein inhibitor JQ-1.
Zhang, C; Su, ZY; Wang, L; Shu, L; Yang, Y; Guo, Y; Pung, D; Bountra, C; Kong, AN;
Biochemical Pharmacology 117:35-45 . doi:
Publication date: September 30, 2016
PMID: 27520485
Patient-derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis.
Eyre, R; Alférez, DG; Spence, K; Kamal, M; Shaw, FL; Simões, BM; Santiago-Gómez, A; Sarmiento-Castro, A; Bramley, M; Absar, M; Saad, Z; Chatterjee, S; Kirwan, C; Gandhi, A; Armstrong, AC; Wardley, AM; O'Brien, CS; Farnie, G; Howell, SJ; Clarke, RB;
Journal of Mammary Gland Biology and Neoplasia :- . doi:
Publication date: September 27, 2016
PMID: 27680982
Development of Selective CBP/P300 Benzoxazepine Bromodomain Inhibitors.
Popp, TA; Tallant, C; Rogers, C; Fedorov, O; Brennan, PE; Müller, S; Knapp, S; Bracher, F;
Journal of Medicinal Chemistry :- . doi:
Publication date: September 26, 2016
PMID: 27673482
The MAPK pathway regulates intrinsic resistance to BET inhibitors in colorectal cancer.
Ma, Y; Wang, L; Neitzel, LR; Loganathan, S; Tang, N; Qin, L; Emily, CE; Guo, Y; Knapp, S; Beauchamp, RD; Lee, E; Wang, J;
Clinical Cancer Research :- . doi:
Publication date: September 26, 2016
PMID: 27678457
Discovery and optimization of a selective ligand for the Switch/Sucrose Non-Fermenting-related bromodomains of Polybromo protein-1 by the use of virtual screening and hydration analysis.
Myrianthopoulos, V; Gaboriaud-Kolar, N; Tallant, C; Hall, ML; Grigoriou, S; Brownlee, PM; Fedorov, O; Rogers, C; Heidenreich, D; Wanior, M; Drosos, N; Mexia, N; Savitsky, P; Bagratuni, T; Kastritis, E; Terpos, E; Filippakopoulos, P; Müller, S; Skaltsounis, AL; Downs, JA; Knapp, S; Mikros, E;
Journal of Medicinal Chemistry :- . doi:
Publication date: September 11, 2016
PMID: 27617704
Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product.
Hughes SJ, Barnard L, Mottaghi K, Tempel W, Antoshchenko T, Hong BS, Allali-Hassani A, Smil D, Vedadi M, Strauss E, Park HW
ACS Infect Dis 2(9):627-641 . doi: 10.1021/acsinfecdis.6b00090
Publication date: September 9, 2016
PMID: 27759386
Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1.
Harrison JS, Cornett EM, Goldfarb D, DaRosa PA, Li ZM, Yan F, Dickson BM, Guo AH, Cantu DV, Kaustov L, Brown PJ, Arrowsmith CH, Erie DA, Major MB, Klevit RE, Krajewski K, Kuhlman B, Strahl BD, Rothbart SB
Elife 5: . doi: 10.7554/eLife.17101
Publication date: September 7, 2016
PMID: 27595565
Chemical probes and inhibitors of bromodomains outside the BET family
Moustakim, M; Clark, PGK; Hay, DA; Dixon, DJ; Brennan, PE;
MedChemComm :- . doi: 10.1039/C6MD00373G
Publication date: September 6, 2016
PMID:

October 2016

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.
Nakazawa Hewitt S, Dranow DM, Horst BG, Abendroth JA, Forte B, Hallyburton I, Jansen C, Baragana B, Choi R, Rivas KL, Hulverson MA, Dumais M, Edwards TE, Lorimer DD, Fairlamb AH, Gray DW, Read KD, Lehane AM, Kirk K, Myler PJ, Wernimont A, Walpole CS, Stacy R, Barrett LK, Gilbert IH, Van Voorhis WC
ACS Infect Dis . doi: 10.1021/acsinfecdis.6b00078
Publication date: October 31, 2016
PMID: 27798837
Characterizing Plexin GTPase Interactions Using Gel Filtration, Surface Plasmon Resonance Spectrometry, and Isothermal Titration Calorimetry.
Muller-Greven J, Kim S, Hota PK, Tong Y, Borthakur S, Buck M
Methods Mol. Biol. 1493:89-105 . doi: 10.1007/978-1-4939-6448-2_6
Publication date: October 28, 2016
PMID: 27787844
Solution NMR structure of the HLTF HIRAN domain: a conserved module in SWI2/SNF2 DNA damage tolerance proteins.
Korzhnev DM, Neculai D, Dhe-Paganon S, Arrowsmith CH, Bezsonova I
J. Biomol. NMR . doi: 10.1007/s10858-016-0070-9
Publication date: October 22, 2016
PMID: 27771863
The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear.
Zhang Q, Wang Z, Hou F, Harding R, Huang X, Dong A, Walker JR, Tong Y
Biochim. Biophys. Acta . doi: 10.1016/j.bbagen.2016.10.019
Publication date: October 21, 2016
PMID: 27776223
Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization.
Gebel, J; Luh, LM; Coutandin, D; Osterburg, C; Löhr, F; Schäfer, B; Frombach, AS; Sumyk, M; Buchner, L; Krojer, T; Salah, E; Mathea, S; Güntert, P; Knapp, S; Dötsch, V;
Cell Death and Differentiation 23:1930-1940 . doi: 10.1038/cdd.2016.83
Publication date: October 6, 2016
PMID: 27716744

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