Publications

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Displaying 1251 - 1300 of 1338

2006

March 2006

Structure and function of human 17beta-hydroxysteroid dehydrogenases.
Lukacik, P; Kavanagh, KL; Oppermann, U;
Molecular and Cellular Endocrinology 248:61-71 . doi: 10.1016/j.mce.2005.12.007
Publication date: March 26, 2006
PMID: 16414178
Molecular recognition of p53 and MDM2 by USP7/HAUSP
Sheng Y, Saridakis V, Sarkari F, Duan S, Wu T, Arrowsmith CH, Frappier L.
Nat Struct Mol Biol. 13(3):285-91 . doi:
Publication date: March 15, 2006
PMID: 16474402
Human farnesyl diphosphate synthase crystal structures with active and inactive bisphosphonates
Evdokimov, A; Pokross, M; Barnett, BL; Kavanagh, K; Oppermann, U; Russell, RGG; McKenna, CE; Ebetino, FH;
Bone 38:S49-S49 . doi: 10.1016/j.bone.2005.12.041
Publication date: March 1, 2006
PMID:
Crystal structures and molecular interactions of risedronate and zoledronate with human farnesyl diphosphate synthase
Kavanagh, KL; Guo, K; Wu, X; Knapp, S; Ebetino, FH; Dunford, JE; Rogers, MJ; Russell, RGG; Oppermann, U;
Bone 38:53-53 . doi: 10.1016/j.bone.2005.12.050
Publication date: March 1, 2006
PMID:
Investigations into the kinetic mechanism of inhibition of farnesyl diphosphate synthase by nitrogen containing bisphosphonates
Dunford, JE; Kavanagh, K; Oppermann, U; Ebetino, FH; Russell, RGG; Rogers, MJ;
Bone 38:S47-S48 . doi: 10.1016/j.bone.2005.12.037
Publication date: March 1, 2006
PMID:
Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
Ebetino, FH; Kashemirov, B; McKenna, CE; Evdokimov, A; Pokross, M; Barnett, BL; Dunford, J; Kavanagh, K; Rogers, MJ; Lundy, MW; Oppermann, U; Russell, RGG;
Bone 38:S49-S50 . doi: 10.1016/j.bone.2005.12.042
Publication date: March 1, 2006
PMID:

February 2006

Ruthenium half-sandwich complexes bound to protein kinase Pim-1.
Debreczeni, JE; Bullock, AN; Atilla, GE; Williams, DS; Bregman, H; Knapp, S; Meggers, E;
Angewandte Chemie International Edition 45:1580-1585 . doi: 10.1002/anie.200503468
Publication date: February 27, 2006
PMID: 16381041
A comparative study of uracil-DNA glycosylases from human and herpes simplex virus type 1.
Krusong, K; Carpenter, EP; Bellamy, SR; Savva, R; Baldwin, GS;
Journal of Biological Chemistry 281:4983-4992 . doi: 10.1074/jbc.M509137200
Publication date: February 24, 2006
PMID: 16306042
Disseminating structural genomics data to the public: from a data dump to an animated story
Abagyan, R; Lee, WH; Raush, E; Budagyan, L; Totrov, M; Sundstrom, M; Marsden, BD;
Trends in Biochemical Sciences 31:76-78 . doi: 10.1016/j.tibs.2005.12.006
Publication date: February 1, 2006
PMID: 16406633

January 2006

COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord.
Yiangou, Y; Facer, P; Durrenberger, P; Chessell, IP; Naylor, A; Bountra, C; Banati, RR; Anand, P;
BMC Neurology 6:12- . doi: 10.1186/1471-2377-6-12
Publication date: January 1, 2006
PMID: 16512913
Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations.
Mukerji, G; Yiangou, Y; Corcoran, SL; Selmer, IS; Smith, GD; Benham, CD; Bountra, C; Agarwal, SK; Anand, P;
BMC Urology 6:6- . doi: 10.1186/1471-2490-6-6
Publication date: January 1, 2006
PMID: 16519806
Pain during ice water test distinguishes clinical bladder hypersensitivity from overactivity disorders.
Mukerji, G; Waters, J; Chessell, IP; Bountra, C; Agarwal, SK; Anand, P;
BMC Urology 6:31- . doi: 10.1186/1471-2490-6-31
Publication date: January 1, 2006
PMID: 17192176
Nogo-A and Nogo-66 receptor in multiple sclerosis and amyotrophic lateral sclerosis spinal cord and injured human peripheral nerves
Durrenberger, P; Facer, P; Casula, MA; Prinjha, R; Moore, S; Woodhams, P; Bountra, C; Ravid, R; Birch, R; Anand, P;
Journal of Neurology, Neurosurgery and Psychiatry 77:130-130 . doi:
Publication date: January 1, 2006
PMID:
Activation and catalysis of the di-heme cytochrome c peroxidase from Paracoccus pantotrophus.
Echalier, A; Goodhew, CF; Pettigrew, GW; Fülöp, V;
Structure 14:107-117 . doi: 10.1016/j.str.2005.09.011
Publication date: January 1, 2006
PMID: 16407070
Breast stem cells and cancer.
Farnie, G; Clarke, RB;
:141-153 . doi:
Publication date: January 1, 2006
PMID: 17939300
High-throughput structural characterisation of therapeutic protein targets
Marsden, BD; Sundstrom, M; Knapp, S;
Expert Opinion on Drug Discovery 1:123-136 . doi: 10.1517/17460441.1.2.123
Publication date: January 1, 2006
PMID:
Inhibition of protein-protein interactions: The discovery of druglike β-catenin inhibitors by combining virtual and biophysical screening
Trosset, JY; Dalvit, C; Knapp, S; Fasolini, M; Veronesi, M; Mantegani, S; Gianellini, LM; Catana, C; Sundström, M; Stouten, PFW; Moll, JK;
Proteins: Structure, Function, and Bioinformatics 64:60-67 . doi: 10.1002/prot.20955
Publication date: January 1, 2006
PMID: 16568448
SDR goes SGC: A structural genomics initiative
Oppermann, U; Kavanagh, K; Guo, KD; Ng, S; Lukacik, P; Wu, XQ; Dubinina, E; Shafqat, N; Bray, J; Marsden, B; Sharma, S; Vedadi, M; von Delft, F; Sundstrom, M;
12:235-241 . doi:
Publication date: January 1, 2006
PMID:
2005

December 2005

Structure and substrate specificity of the Pim-1 kinase.
Bullock, AN; Debreczeni, J; Amos, AL; Knapp, S; Turk, BE;
Journal of Biological Chemistry 280:41675-41682 . doi: 10.1074/jbc.M510711200
Publication date: December 16, 2005
PMID: 16227208
Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease.
McDonough, MA; Kavanagh, KL; Butler, D; Searls, T; Oppermann, U; Schofield, CJ;
Journal of Biological Chemistry 280:41101-41110 . doi: 10.1074/jbc.M507528200
Publication date: December 9, 2005
PMID: 16186124
Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase.
Bullock, AN; Debreczeni, JE; Fedorov, OY; Nelson, A; Marsden, BD; Knapp, S;
Journal of Medicinal Chemistry 48:7604-7614 . doi: 10.1021/jm0504858
Publication date: December 1, 2005
PMID: 16302800

November 2005

Structure of a central stalk subunit F of prokaryotic V-type ATPase/synthase from Thermus thermophilus.
Makyio, H; Iino, R; Ikeda, C; Imamura, H; Tamakoshi, M; Iwata, M; Stock, D; Bernal, RA; Carpenter, EP; Yoshida, M; Yokoyama, K; Iwata, S;
The EMBO Journal 24:3974-3983 . doi: 10.1038/sj.emboj.7600859
Publication date: November 16, 2005
PMID: 16281059
Enzymology and Molecular Biology of Carbonyl Metabolism
Marsden, B; Oppermann, U; Kavanagh, K; Guo, K; Ng, S; Lukacik, P; Wu, X; Dubinia, E; Shafqat, N; Bray, J; Sharma, S; Vedadi, M;
12:- . doi:
Publication date: November 11, 2005
PMID:
NK cells: elusive players in autoimmunity
Johansson S, Berg L, Hall H, Hoglund P.
Trends Immunol 26(11):613-8 . doi: 10.1016/j.it.2005.08.008
Publication date: November 1, 2005
PMID: 16118064

October 2005

Exogenous high-mobility group box 1 protein induces myocardial regeneration after infarction via enhanced cardiac C-kit+ cell proliferation and differentiation.
Limana, F; Germani, A; Zacheo, A; Kajstura, J; Di Carlo, A; Borsellino, G; Leoni, O; Palumbo, R; Battistini, L; Rastaldo, R; Müller, S; Pompilio, G; Anversa, P; Bianchi, ME; Capogrossi, MC;
Circulation Research 97:e73-e83 . doi: 10.1161/01.RES.0000186276.06104.04
Publication date: October 13, 2005
PMID: 16166556

September 2005

Identification of an intestinal heme transporter.
Shayeghi, M; Latunde-Dada, GO; Oakhill, JS; Laftah, AH; Takeuchi, K; Halliday, N; Khan, Y; Warley, A; McCann, FE; Hider, RC; Frazer, DM; Anderson, GJ; Vulpe, CD; Simpson, RJ; McKie, AT;
Cell 122:789-801 . doi: 10.1016/j.cell.2005.06.025
Publication date: September 8, 2005
PMID: 16143108

August 2005

Human farnesyl diphosphate synthase (FDFS): Crystal structure and molecular interactions with Nnitrogen-containing bisphosphonates.
Kavanagh, K; Guo, K; Wu, X; Knapp, S; Ebetino, FH; Dunford, JE; Rogers, MJ; Russell, RGG; Oppermann, U;
Journal of Bone and Mineral Research 20:S95-S96 . doi:
Publication date: August 31, 2005
PMID:

July 2005

Sodium channel Nav1.8 immunoreactivity in painful human dental pulp.
Renton, T; Yiangou, Y; Plumpton, C; Tate, S; Bountra, C; Anand, P;
BMC Oral Health 5:5- . doi: 10.1186/1472-6831-5-5
Publication date: July 6, 2005
PMID: 16001984

April 2005

Two-wavelength MAD phasing and radiation damage: a case study.
González, A; von Delft, F; Liddington, RC; Bakolitsa, C;
Journal of Synchrotron Radiation 12:285-291 . doi: 10.1107/S0909049505003249
Publication date: April 30, 2005
PMID: 15840912

March 2005

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain.
Chessell, IP; Hatcher, JP; Bountra, C; Michel, AD; Hughes, JP; Green, P; Egerton, J; Murfin, M; Richardson, J; Peck, WL; Grahames, CB; Casula, MA; Yiangou, Y; Birch, R; Anand, P; Buell, GN;
Pain 114:386-396 . doi: 10.1016/j.pain.2005.01.002
Publication date: March 31, 2005
PMID: 15777864
Increased capsaicin receptor TRPV1 in skin nerve fibres and related vanilloid receptors TRPV3 and TRPV4 in keratinocytes in human breast pain.
Gopinath, P; Wan, E; Holdcroft, A; Facer, P; Davis, JB; Smith, GD; Bountra, C; Anand, P;
BMC Women's Health 5:2- . doi: 10.1186/1472-6874-5-2
Publication date: March 8, 2005
PMID: 15755319
The structural genomics consortium: High-output structure determination
Gileadi, O; Colebrook, S; Burgess, N; Berridge, G; Haroniti, A; Shrestha, B; Smee, C; Sundstrom, M;
The FASEB Journal 19:A315-A315 . doi:
Publication date: March 4, 2005
PMID:
Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction.
Hardcastle, IR; Ahmed, SU; Atkins, H; Calvert, AH; Curtin, NJ; Farnie, G; Golding, BT; Griffin, RJ; Guyenne, S; Hutton, C; Källblad, P; Kemp, SJ; Kitching, MS; Newell, DR; Norbedo, S; Northen, JS; Reid, RJ; Saravanan, K; Willems, HM; Lunec, J;
Bioorganic and Medicinal Chemistry Letters 15:1515-1520 . doi: 10.1016/j.bmcl.2004.12.061
Publication date: March 1, 2005
PMID: 15713419
Crystal structure of an alanine-glyoxylate aminotransferase from Anabaena sp. at 1.70 A resolution reveals a noncovalently linked PLP cofactor.
Han, GW; Schwarzenbacher, R; Page, R; Jaroszewski, L; Abdubek, P; Ambing, E; Biorac, T; Canaves, JM; Chiu, HJ; Dai, X; Deacon, AM; DiDonato, M; Elsliger, MA; Godzik, A; Grittini, C; Grzechnik, SK; Hale, J; Hampton, E; Haugen, J; Hornsby, M; Klock, HE; Koesema, E; Kreusch, A; Kuhn, P; Lesley, SA; Levin, I; McMullan, D; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Nigoghossian, E; Ouyang, J; Paulsen, J; Quijano, K; Reyes, R; Sims, E; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; von Delft, F; Wang, X; West, B; White, A; Wolf, G; Xu, Q; Zagnitko, O; Hodgson, KO; Wooley, J; Wilson, IA;
Proteins: Structure, Function, and Bioinformatics 58:971-975 . doi: 10.1002/prot.20360
Publication date: March 1, 2005
PMID: 15657930
Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 2.80 A resolution reveals a new fold.
Xu, Q; Schwarzenbacher, R; McMullan, D; Abdubek, P; Ambing, E; Biorac, T; Canaves, JM; Chiu, HJ; Dai, X; Deacon, AM; DiDonato, M; Elsliger, MA; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Hornsby, M; Jaroszewski, L; Klock, HE; Koesema, E; Kreusch, A; Kuhn, P; Lesley, SA; Levin, I; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Reyes, R; Robb, A; Sims, E; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; von Delft, F; Wang, X; West, B; White, A; Wolf, G; Zagnitko, O; Hodgson, KO; Wooley, J; Wilson, IA;
Proteins: Structure, Function, and Bioinformatics 58:976-981 . doi: 10.1002/prot.20364
Publication date: March 1, 2005
PMID: 15651027
The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] is effective in animal models of neuropathic pain and central sensitization.
Bingham, S; Beswick, PJ; Bountra, C; Brown, T; Campbell, IB; Chessell, IP; Clayton, N; Collins, SD; Davey, PT; Goodland, H; Gray, N; Haslam, C; Hatcher, JP; Hunter, AJ; Lucas, F; Murkitt, G; Naylor, A; Pickup, E; Sargent, B; Summerfield, SG; Stevens, A; Stratton, SC; Wiseman, J;
Journal of Pharmacology and Experimental Therapeutics 312:1161-1169 . doi: 10.1124/jpet.104.075267
Publication date: March 1, 2005
PMID: 15572651

February 2005

Crystal structure and solution NMR dynamics of a D (type II) peroxiredoxin glutaredoxin and thioredoxin dependent: a new insight into the peroxiredoxin oligomerism.
Echalier, A; Trivelli, X; Corbier, C; Rouhier, N; Walker, O; Tsan, P; Jacquot, JP; Aubry, A; Krimm, I; Lancelin, JM;
Biochemistry 44:1755-1767 . doi: 10.1021/bi048226s
Publication date: February 15, 2005
PMID: 15697201
Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 A resolution.
Arndt, JW; Schwarzenbacher, R; Page, R; Abdubek, P; Ambing, E; Biorac, T; Canaves, JM; Chiu, HJ; Dai, X; Deacon, AM; DiDonato, M; Elsliger, MA; Godzik, A; Grittini, C; Grzechnik, SK; Hale, J; Hampton, E; Han, GW; Haugen, J; Hornsby, M; Klock, HE; Koesema, E; Kreusch, A; Kuhn, P; Jaroszewski, L; Lesley, SA; Levin, I; McMullan, D; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Nigoghossian, E; Ouyang, J; Peti, WS; Quijano, K; Reyes, R; Sims, E; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; von Delft, F; Wang, X; West, B; White, A; Wolf, G; Xu, Q; Zagnitko, O; Hodgson, KO; Wooley, J; Wilson, IA;
Proteins: Structure, Function, and Bioinformatics 58:755-758 . doi: 10.1002/prot.20336
Publication date: February 15, 2005
PMID: 15624212
The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions.
Ogg, D; Elleby, B; Norström, C; Stefansson, K; Abrahmsén, L; Oppermann, U; Svensson, S;
Journal of Biological Chemistry 280:3789-3794 . doi: 10.1074/jbc.M412463200
Publication date: February 4, 2005
PMID: 15542590

January 2005

X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster.
Elkins, JM; Kershaw, NJ; Schofield, CJ;
Biochemical Journal 385:565-573 . doi: 10.1042/BJ20040814
Publication date: January 15, 2005
PMID: 15352873
An electronically tunable ultrafast laser source applied to fluorescence imaging and fluorescence lifetime imaging microscopy
Lanigan, PMP; Dunsby, C; McGinty, J; Elson, DS; Requejo-Isidro, J; Munro, I; Galletly, N; Treanor, B; Onfelt, B; McCann, F; Davis, DM; Neil, MAA; French, PMW; IEEE, ;
Optics InfoBase Conference Papers :1366-1368 . doi:
Publication date: January 1, 2005
PMID:
Regulation of the wild-type and Y1235D mutant met kinase activation
Cristiani, C; Rusconi, L; Perego, R; Schiering, N; Kalisz, HM; Knapp, S; Isacchi, A;
Biochemistry 44:14110-14119 . doi: 10.1021/bi051242k
Publication date: January 1, 2005
PMID: 16245927
An electronically tunable ultrafast laser source applied to fluorescence imaging and microscopy including fluorescence lifetime imaging
Dunsby, C; Lanigan, PMP; McGinty, J; De Beule, PAA; Auksorius, E; Schimpf, DN; Elson, DS; Requejo-Isidro, J; Munro, I; Galletly, N; Treanor, B; Önfelt, B; McCann, F; Davis, DM; Neil, MAA; French, PMW;
:- . doi: 10.1109/CLEOE.2005.1568395
Publication date: January 1, 2005
PMID:
Probing the access of protons to the K pathway in the Paracoccus denitrificans cytochrome c oxidase
Richter, O-MH; Dürr, KL; Kannt, A; Ludwig, B; Scandurra, FM; Giuffrè, A; Sarti, P; Hellwig, P;
The Federation of European Biochemical Societies (FEBS) Journal 272:404-412 . doi: 10.1111/j.1742-4658.2004.04480.x
Publication date: January 1, 2005
PMID:
2004

December 2004

An electronically tunable ultrafast laser source applied to fluorescence imaging and fluorescence lifetime imaging microscopy
Dunsby, C; Lanigan, PMP; McGinty, J; Elson, DS; Requejo-Isidro, J; Munro, I; Galletly, N; McCann, F; Treanor, B; Onfelt, B; Davis, DM; Neil, MAA; French, PMW;
Journal of Physics D: Applied Physics 37:3296-3303 . doi: 10.1088/0022-3727/37/23/011
Publication date: December 7, 2004
PMID:
Coupling PAF signaling to dynein regulation: Structure of LIS1 in complex with PAF-acetylhydrolase
Tarricone, C; Perrina, F; Monzani, S; Massimiliano, L; Kim, MH; Derewenda, ZS; Knapp, S; Tsai, LH; Musacchio, A;
Neuron 44:809-821 . doi: 10.1016/j.neuron.2004.11.019
Publication date: December 2, 2004
PMID: 15572112

November 2004

nNOS expression following inferior alveolar nerve injury in the ferret.
Davies, SL; Loescher, AR; Clayton, NM; Bountra, C; Robinson, PP; Boissonade, FM;
Brain Research 1027:11-17 . doi: 10.1016/j.brainres.2004.08.062
Publication date: November 19, 2004
PMID: 15494152
Membrane nanotubes network immune cells
Davis, DM; Onfelt, B; Nedvetzki, S; Vanherberghen, B; McCann, FE; Carlin, LM; Taner, SB; Eleme, K; Treanor, B; de Almeida, C; Williams, G; Nolte, E; Hoen, T; Yanagi, K;
Molecular Biology of the Cell 15:6A-6A . doi:
Publication date: November 1, 2004
PMID:
Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors.
Beswick, P; Bingham, S; Bountra, C; Brown, T; Browning, K; Campbell, I; Chessell, I; Clayton, N; Collins, S; Corfield, J; Guntrip, S; Haslam, C; Lambeth, P; Lucas, F; Mathews, N; Murkit, G; Naylor, A; Pegg, N; Pickup, E; Player, H; Price, H; Stevens, A; Stratton, S; Wiseman, J;
Bioorganic and Medicinal Chemistry Letters 14:5445-5448 . doi: 10.1016/j.bmcl.2004.07.089
Publication date: November 1, 2004
PMID: 15454242

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