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Epigenetics and Inflammation

Group Site: 
oxford
Group Leader: 

Udo Oppermann

Group Info

Research Areas

Epigenetic mechanisms in biology

Epigenetics describes inherited and acquired modifications of DNA, histones and proteins, which play critical roles in the regulation of gene expression, in chromosome stability, genomic imprinting, and stem cell fate. Alterations in epigenetic signaling are involved in major diseases including cancer, metabolic and neurodegenerative diseases. A dissection of the molecular mechanisms of epigenetic signaling will be facilitated by the widespread availability of small molecule chemical probes that are selective for specific components of the epigenetic machinery. Chemical probes will complement knockouts and RNAi approaches to dissect these biological networks.

In our group we focus on three areas of relevance- understanding structural and functional features of protein e.g. histone methylation and recognition, as well as applying chemical biology to two areas of biomedical importance with respect to regenerative medicine approaches, namely inflammation and stem cell biology.


Structures

To follow.

For now, feel free take a look at all the SGC's structures.

Group Members
Catrine Johansson
Carina Gileadi
Stan Ng
Michelle Daniel
Publications

2011

  1. Evans DM, Spencer CC, Pointon JJ, Su Z, Harvey D, Kochan G, Oppermann U, Dilthey A, Pirinen M, Stone MA, Appleton L, Moutsianis L, Leslie S, Wordsworth T, Kenna TJ, Karaderi T, Thomas GP, Ward MM, Weisman MH, Farrar C, Bradbury LA, Danoy P, Inman RD, Maksymowych W, Gladman D, Rahman P, Morgan A, Marzo-Ortega H, Bowness P, Gaffney K, Gaston JS, Smith M, Bruges-Armas J, Couto AR, Sorrentino R, Paladini F, Ferreira MA, Xu H, Liu Y, Jiang L, Lopez-Larrea C, Díaz-Peña R, López-Vázquez A, Zayats T, Band G, Bellenguez C, Blackburn H, Blackwell JM, Bramon E, Bumpstead SJ, Casas JP, Corvin A, Craddock N, Deloukas P, Dronov S, Duncanson A, Edkins S, Freeman C, Gillman M, Gray E, Gwilliam R, Hammond N, Hunt SE, Jankowski J, Jayakumar A, Langford C, Liddle J, Markus HS, Mathew CG, McCann OT, McCarthy MI, Palmer CN, Peltonen L, Plomin R, Potter SC, Rautanen A, Ravindrarajah R, Ricketts M, Samani N, Sawcer SJ, Strange A, Trembath RC, Viswanathan AC, Waller M, Weston P, Whittaker P, Widaa S, Wood NW, McVean G, Reveille JD, Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet. 2011 Jul 10. doi: 10.1038/ng.873. [Epub ahead of print]
  2. Zhang Z, Kochan GT, Ng SS, Kavanagh KL, Oppermann U, Schofield CJ, McDonough MA Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase. Biochem Biophys Res Commun. 2011 May 20;408(4):553-8. Epub 2011 Apr 21.
  3. Luo X, Liu Y, Kubicek S, Myllyharju J, Tumber A, Ng SS, Che K, Podoll JD, Heightman TD, Oppermann UC, Schreiber SL, Wang X A Selective Inhibitor and Probe of the Cellular Functions of Jumonji C Domain-Containing Histone Demethylases. J Am Chem Soc. 2011 May 17. [Epub ahead of print]
  4. Kochan G, Krojer T, Harvey D, Fischer R, Chen L, Vollmar M, von Delft F, Kavanagh KL, Brown MA, Bowness P, Wordsworth P, Kessler BM, Oppermann U Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming. Proc Natl Acad Sci U S A. 2011 May 10;108(19):7745-50. Epub 2011 Apr 20.
  5. Lee WH, Yue WW, Raush E, Totrov M, Abagyan R, Oppermann U, Marsden BD Interactive JIMD articles using the iSee concept: turning a new page on structural biology data. J Inherit Metab Dis. 2011 Apr 21. [Epub ahead of print]
  6. Ebetino FH, Hogan AM, Sun S, Tsoumpra MK, Duan X, Triffitt JT, Kwaasi AA, Dunford JE, Barnett BL, Oppermann U, Lundy MW, Boyde A, Kashemirov BA, McKenna CE, Russell RG The relationship between the chemistry and biological activity of the bisphosphonates. Bone. 2011 Apr 9. [Epub ahead of print]
  7. Egger S, Chaikuad A, Kavanagh KL, Oppermann U, Nidetzky B Structure and mechanism of human UDP-glucose 6-dehydrogenase. J Biol Chem. 2011 Apr 18. [Epub ahead of print]
  8. Picaud S, Kavanagh KL, Yue WW, Lee WH, Muller-Knapp S, Gileadi O, Sacchettini J, Oppermann U Structural basis of fumarate hydratase deficiency. J Inherit Metab Dis. 2011 Mar 29. [Epub ahead of print]
  9. Yue WW, Oppermann U High-throughput structural biology of metabolic enzymes and its impact on human diseases. J Inherit Metab Dis. 2011 Feb 22. [Epub ahead of print]
  10. Bountra C, Oppermann U, Heightman TD Animal Models of Epigenetic Regulation in Neuropsychiatric Disorders. Curr Top Behav Neurosci. 2011 Jan 12. [Epub ahead of print]
  11. Carr SM, Munro S, Kessler B, Oppermann U, La Thangue NB Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein. EMBO J. 2011 Jan 19;30(2):317-27. Epub 2010 Nov 30.
  12. Chaikuad A, Shafqat N, Al-Mokhtar R, Cameron G, Clarke AR, Brady L, Oppermann U, Frayne J, Yue WW Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDS. Biochem J. 2011 Jan 26. [Epub ahead of print]

2010

  1. Niesen FH, Schultz L, Jadhav A, Bhatia C, Guo K, Maloney DJ, Pilka ES, Wang M, Oppermann U, Heightman TD, Simeonov A High-Affinity Inhibitors of Human NAD-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships. PLOS ONE. 2010 Nov 2;5(11):e13719.
  2. Artz JD, Wernimont AK, Dunford JE, Schapira M, Dong A, Zhao Y, Lew J, Russell RG, Ebetino FH, Oppermann U, Hui R Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites. J BIOL CHEM. 2010 Nov 17. [Epub ahead of print]
  3. King ON, Li XS, Sakurai M, Kawamura A, Rose NR, Ng SS, Quinn AM, Rai G, Mott BT, Beswick P, Klose RJ, Oppermann U, Jadhav A, Heightman TD, Maloney DJ, Schofield CJ, Simeonov A Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. PLOS ONE. 2010 Nov 23;5(11):e15535.
  4. Johansson C, Roos AK, Montano SJ, Sengupta R, Filippakopoulos P, Guo K, von Delft F, Holmgren A, Oppermann U, Kavanagh KL The Crystal structure of human GLRX5: iron sulphur cluster coordination, tetrameric assembly and monomer activity. BIOCHEM J. 2010 Oct 29. [Epub ahead of print]
  5. Wang M, Mok MW, Harper H, Lee WH, Min J, Knapp S, Oppermann U, Marsden B, Schapira M Structural genomics of histone tail recognition. BIOINFORMATICS. 2010 Oct 15;26(20):2629-30. Epub 2010 Aug 24.
  6. Egger S, Chaikuad A, Kavanagh KL, Oppermann U, Nidetzky B UDP-glucose dehydrogenase: structure and function of a potential drug target. BIOCHEM SOC T. 2010 Oct;38(5):1378-85.
  7. Porté S, Moeini A, Reche I, Shafqat N, Oppermann U, Farrés J, Parés X Kinetic and structural evidence of the alkenal/one reductase specificity of human zeta-crystallin. CELL MOL LIFE SCI. 2010 Sep 11. [Epub ahead of print]
  8. Froese DS, Kochan G, Muniz J, Wu X, Gileadi C, Ugochukwu E, Krysztofinska E, Gravel RA, Oppermann U, Yue WW Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-coa mutase and insight into their complex formation. J BIOL CHEM. 2010 Sep 28. [Epub ahead of print]
  9. Mantri M, Krojer T, Bagg EA, Webby CJ, Butler DS, Kochan G, Kavanagh KL, Oppermann U, McDonough MA, Schofield CJ Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6. J MOL BIOL. 2010 Aug 13;401(2):211-22.
  10. Middleton MR, Knox R, Cattell E, Oppermann U, Midgley R, Ali R, Auton T, Agarwal R, Anderson D, Sarker D, Judson I, Osawa T, Spanswick VJ, Davies S, Hartley JA, Kerr DJ Quinone oxidoreductase-2-mediated prodrug cancer therapy.Sci Transl Med. 2010 Jul 14;2(40):40ra50.
  11. Kallberg Y, Oppermann U, Persson B Classification of the short-chain dehydrogenase / reductase superfamily using hidden Markov models. FEBS J. 2010 May;277(10):2375-86.
  12. Healy S, McDonald MK, Wu X, Yue WW, Kochan G, Oppermann U, Gravel RA Structural Impact of Human and Escherichia coli Biotin Carboxyl Carrier Proteins on Biotin Attachment. BIOCHEMISTRY-US. 2010 May 12. [Epub ahead of print]
  13. Jörnvall H, Hedlund J, Bergman T, Oppermann U, Persson B Superfamilies SDR and MDR: from early ancestry to present forms. Emergence of three lines, a Zn-metalloenzyme, and distinct variabilities. BIOCHEM BIOPH RES CO. 2010 May 21;396(1):125-30. Review.
  14. Kawamura A, Tumber A, Rose NR, King ON, Daniel M, Oppermann U, Heightman TD, Schofield C Development of homogeneous luminescence assays for histone demethylase catalysis and binding. ANAL BIOCHEM. 2010 Apr 29. [Epub ahead of print]
  15. Brocker C, Lassen N, Estey T, Pappa A, Cantore M, Orlova VV, Chavakis T, Kavanagh KL, Oppermann U, Vasiliou V Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress. J BIOL CHEM. 2010 Mar 5. [Epub ahead of print]
  16. Shafqat N, Turnbull A, Zschocke J, Oppermann U, Yue WW Crystal Structures of Human HMG-CoA Synthase Isoforms Provide Insights into Inherited Ketogenesis Disorders and Inhibitor Design. J MOL BIOL. 2010 Mar 25. [Epub ahead of print]
  17. Yue WW, Hozjan V, Ge W, Loenarz C, Cooper CD, Schofield CJ, Kavanagh KL, Oppermann U, McDonough MA Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase. FEBS LETT. 2010 Feb 19;584(4):825-30. Epub 2010 Jan 12.
  18. Sakurai M, Rose NR, Schultz L, Quinn AM, Jadhav A, Ng SS, Oppermann U, Schofield CJ, Simeonov A A miniaturized screen for inhibitors of Jumonji histone demethylases. MOL BIOSYST. 2010 Feb;6(2):357-64. Epub 2009 Oct 8.
  19. Rauschenberger K, Schöler K, Sass JO, Sauer S, Djuric Z, Rumig C, Wolf NI, Okun JG, Kölker S, Schwarz H, Fischer C, Grziwa B, Runz H, Nümann A, Shafqat N, Kavanagh KL, Hämmerling G, Wanders RJ, Shield JP, Wendel U, Stern D, Nawroth P, Hoffmann GF, Bartram CR, Arnold B, Bierhaus A, Oppermann U, Steinbeisser H, Zschocke J A non-enzymatic function of 17beta-hydroxysteroid dehydrogenase type 10 is required for mitochondrial integrity and cell survival.EMBO MOL MED. 2010 Feb;2(2):51-62.
  20. Rose NR, Woon EC, Kingham GL, King ON, Mecinovic J, Clifton IJ, Ng SS, Talib-Hardy J, Oppermann U, McDonough MA, Schofield CJ Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches. J MED CHEM. 2010 Feb 25;53(4):1810-8.
  21. Froese DS, Healy S, McDonald M, Kochan G, Oppermann U, Niesen FH, Gravel RA Thermolability of mutant MMACHC protein in the vitamin B12-responsive cblC disorder. MOL GENET METAB. 2010 Feb 15. [Epub ahead of print]
  22. Quinn AM, Bedford MT, Espejo A, Spannhoff A, Austin CP, Oppermann U, Simeonov A A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics. NUCLEIC ACIDS RES. 2010 Jan;38(2):e11. Epub 2009 Nov 6.

2009

  1. Pilka ES, Niesen FH, Lee WH, El-Hawari Y, Dunford JE, Kochan G, Wsol V, Martin HJ, Maser E, Oppermann U Structural basis for substrate specificity in human monomeric carbonyl reductases. PLOS ONE. 2009 Oct 20;4(10):e7113.
  2. Picaud SS, Muniz JR, Kramm A, Pilka ES, Kochan G, Oppermann U, Yue WW Crystal structure of human carbonic anhydrase-related protein VIII reveals the basis for catalytic silencing. PROTEINS. 2009 Aug 1;76(2):507-11. No abstract available.
  3. Harvey D, Pointon JJ, Evans DM, Karaderi T, Farrar C, Appleton LH, Sturrock RD, Stone MA, Oppermann U, Brown MA, Wordsworth BP Investigating the Genetic Association between ERAP1 and Ankylosing Spondylitis. HUM MOL GENET. 2009 Aug 18. [Epub ahead of print]
  4. Bunkoczi G, Misquitta S, Wu X, Lee WH, Rojkova A, Kochan G, Kavanagh KL, Oppermann U, Smith S Structural basis for different specificities of acyltransferases associated with the human cytosolic and mitochondrial fatty acid synthases. CHEM BIOL. 2009 Jun 26;16(6):667-75.
  5. Porté S, Valencia E, Yakovtseva EA, Borràs E, Shafqat N, Debreczeny JE, Pike AC, Oppermann U, Farrés J, Fita I, Parés X Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3. J BIOL CHEM. 2009 Jun 19;284(25):17194-205. Epub 2009 Apr 5.
  6. Kochan G, Pilka ES, von Delft F, Oppermann U, Yue WW Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A. J MOL BIOL. 2009 May 22;388(5):997-1008. Epub 2009 Apr 1.
  7. El-Hawari Y, Favia AD, Pilka ES, Kisiela M, Oppermann U, Martin HJ, Maser E Analysis of the substrate-binding site of human carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis. CHEM-BIOL INTERACT. 2009 Mar 16;178(1-3):234-41. Epub 2008 Nov 18.
  8. Bray JE, Marsden BD, Oppermann U The human short-chain dehydrogenase/reductase (SDR) superfamily: a bioinformatics summary. CHEM-BIOL INTERACT. 2009 Mar 16;178(1-3):99-109. Epub 2008 Nov 17.
  9. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. CHEM-BIOL INTERACT. 2009 Mar 16;178(1-3):94-8. Epub 2008 Nov 5.
  10. Hult M, Ortsäter H, Schuster G, Graedler F, Beckers J, Adamski J, Ploner A, Jörnvall H, Bergsten P, Oppermann U Short-term glucocorticoid treatment increases insulin secretion in islets derived from lean mice through multiple pathways and mechanisms. MOL CELL ENDOCRINOL. 2009 Mar 25;301(1-2):109-16. Epub 2008 Oct 15.
  11. Lee WH, Lukacik P, Guo K, Ugochukwu E, Kavanagh KL, Marsden B, Oppermann U Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4. MOL CELL ENDOCRINOL. 2009 Mar 25;301(1-2):199-204. Epub 2008 Oct 22.
  12. Ng SS, Yue WW, Oppermann U, Klose RJ Dynamic protein methylation in chromatin biology. CELL MOL LIFE SCI. 2009 Feb;66(3):407-22. Review.
  13. Zimmermann TJ, Niesen FH, Pilka ES, Knapp S, Oppermann U, Maier ME Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone. BIOORGAN MED CHEM. 2009 Jan 15;17(2):530-6. Epub 2008 Dec 6.

2008

  1. Kavanagh KL, Jörnvall H, Persson B, Oppermann U Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes.CELL MOL LIFE SCI. 2008 Dec;65(24):3895-906. Review.
  2. Artz JD, Dunford JE, Arrowood MJ, Dong A, Chruszcz M, Kavanagh KL, Minor W, Russell RG, Ebetino FH, Oppermann U, Hui R Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis. CHEM BIOL. 2008 Dec 22;15(12):1296-306.
  3. Rose NR, Ng SS, Mecinovic J, Liénard BM, Bello SH, Sun Z, McDonough MA, Oppermann U, Schofield CJ Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. J MED CHEM. 2008 Nov 27;51(22):7053-6.
  4. Wu X, Oppermann M, Berndt KD, Bergman T, Jörnvall H, Knapp S, Oppermann U Thermal unfolding of the archaeal DNA and RNA binding protein Ssh10. BIOCHEM BIOPH RES CO. 2008 Sep 5;373(4):482-7. Epub 2008 Jun 20.
  5. Burgess-Brown NA, Sharma S, Sobott F, Loenarz C, Oppermann U, Gileadi O Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study. PROTEIN EXPRES PURIF. 2008 May;59(1):94-102. Epub 2008 Jan 26.
  6. Dunford JE, Kwaasi AA, Rogers MJ, Barnett BL, Ebetino FH, Russell RG, Oppermann U, Kavanagh KL Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase. J MED CHEM. 2008 Apr 10;51(7):2187-95. Epub 2008 Mar 8.
  7. Filling C, Keller B, Hirschberg D, Marschall HU, Jörnvall H, Bennett MJ, Oppermann U Role of short-chain hydroxyacyl CoA dehydrogenases in SCHAD deficiency. BIOCHEM BIOPH RES CO. 2008 Mar 28;368(1):6-11. Epub 2007 Nov 26.
  8. Hozjan V, Guo K, Wu X, Oppermann U Ligand supplementation as a method to increase soluble heterologous protein production. EXPERT REV PROTEOMIC. 2008 Feb;5(1):137-43. Review.
  9. Gräslund S, Nordlund P, Weigelt J, Hallberg BM, Bray J, Gileadi O, Knapp S, Oppermann U, Arrowsmith C, Hui R, Ming J, dhe-Paganon S, Park HW, Savchenko A, Yee A, Edwards A, Vincentelli R, Cambillau C, Kim R, Kim SH, Rao Z, Shi Y, Terwilliger TC, Kim CY, Hung LW, Waldo GS, Peleg Y, Albeck S, Unger T, Dym O, Prilusky J, Sussman JL, Stevens RC, Lesley SA, Wilson IA, Joachimiak A, Collart F, Dementieva I, Donnelly MI, Eschenfeldt WH, Kim Y, Stols L, Wu R, Zhou M, Burley SK, Emtage JS, Sauder JM, Thompson D, Bain K, Luz J, Gheyi T, Zhang F, Atwell S, Almo SC, Bonanno JB, Fiser A, Swaminathan S, Studier FW, Chance MR, Sali A, Acton TB, Xiao R, Zhao L, Ma LC, Hunt JF, Tong L, Cunningham K, Inouye M, Anderson S, Janjua H, Shastry R, Ho CK, Wang D, Wang H, Jiang M, Montelione GT, Stuart DI, Owens RJ, Daenke S, Schütz A, Heinemann U, Yokoyama S, Büssow K, Gunsalus KC Protein production and purification. NAT METHODS. 2008 Feb;5(2):135-46. Review. Erratum in: Nat Methods. 2008 Apr;5(4):369. Hallberg, B Martin [added].
  10. Ludwig C, Michiels PJ, Wu X, Kavanagh KL, Pilka E, Jansson A, Oppermann U, Günther UL SALMON: solvent accessibility, ligand binding, and mapping of ligand orientation by NMR spectroscopy. J MED CHEM. 2008 Jan 10;51(1):1-3. Epub 2007 Dec 7.

2007

  1. Simeonov A, Yasgar A, Klumpp C, Zheng W, Shafqat N, Oppermann U, Austin CP, Inglese J Evaluation of micro-parallel liquid chromatography as a method for HTS-coupled actives verification. Assay Drug Dev Technol. 2007 Dec;5(6):815-24.
  2. Bunkoczi G, Pasta S, Joshi A, Wu X, Kavanagh KL, Smith S, Oppermann U Mechanism and substrate recognition of human holo ACP synthase. Chem Biol. 2007 Nov;14(11):1243-53.
  3. Gileadi O, Knapp S, Lee WH, Marsden BD, Müller S, Niesen FH, Kavanagh KL, Ball LJ, von Delft F, Doyle DA, Oppermann UC, Sundstrom M The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins. J Struct Funct Genomics. 2007 Sep;8(2-3):107-19. Epub 2007 Oct 12. Review.
  4. Ng SS, Kavanagh KL, McDonough MA, Butler D, Pilka ES, Lienard BM, Bray JE, Savitsky P, Gileadi O, von Delft F, Rose NR, Offer J, Scheinost JC, Borowski T, Sundstrom M, Schofield CJ, Oppermann U Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. Nature. 2007 Jul 5;448(7149):87-91. Epub 2007 Jun 24.
  5. Wu X, Knapp S, Stamp A, Stammers DK, Jörnvall H, Dellaporta SL, Oppermann U Biochemical characterization of TASSELSEED 2, an essential plant short-chain dehydrogenase/reductase with broad spectrum activities. FEBS J. 2007 Mar;274(5):1172-82.
  6. Johansson C, Kavanagh KL, Gileadi O, Oppermann U Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria. J Biol Chem. 2007 Feb 2;282(5):3077-82. Epub 2006 Nov 22.
  7. Wu X, Lukacik P, Kavanagh KL, Oppermann U SDR-type human hydroxysteroid dehydrogenases involved in steroid hormone activation. Mol Cell Endocrinol. 2007 Feb;265-266:71-6. Epub 2007 Jan 17. Review.
  8. Russell RG, Xia Z, Dunford JE, Oppermann U, Kwaasi A, Hulley PA, Kavanagh KL, Triffitt JT, Lundy MW, Phipps RJ, Barnett BL, Coxon FP, Rogers MJ, Watts NB, Ebetino FH Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy. Ann N Y Acad Sci. 1117: 209-57.
  9. Oppermann U Carbonyl reductases: the complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology. Annu Rev Pharmacol Toxicol. 2007;47:293-322. Review.

2006

  1. Oppermann U Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases? Endocr Metab Immune Disord Drug Targets. 2006 Sep;6(3):259-69. Review.
  2. Shafqat N, Shafqat J, Eissner G, Marschall HU, Tryggvason K, Eriksson U, Gabrielli F, Lardy H, Jörnvall H, Oppermann U Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue. Cell Mol Life Sci. 2006 May;63(10):1205-13.
  3. Guo K, Lukacik P, Papagrigoriou E, Meier M, Lee WH, Adamski J, Oppermann U Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase. J Biol Chem. 2006 Apr 14;281(15):10291-7. Epub 2005 Dec 27.
  4. Hult M, Shafqat N, Elleby B, Mitschke D, Svensson S, Forsgren M, Barf T, Vallgårda J, Abrahmsén L, Oppermann U Active site variability of type 1 11beta-hydroxysteroid dehydrogenase revealed by selective inhibitors and cross-species comparisons. Mol Cell Endocrinol. 2006 Mar 27;248(1-2):26-33. Epub 2006 Jan 20.
  5. Lukacik P, Kavanagh KL, Oppermann U Structure and function of human 17beta-hydroxysteroid dehydrogenases. Mol Cell Endocrinol. 2006 Mar 27;248(1-2):61-71. Epub 2006 Jan 18. Review.
  6. Kavanagh KL, Dunford JE, Bunkoczi G, Russell RG, Oppermann U The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding J Biol Chem, 2006, 281(31): 22004-12
  7. Kavanagh KL, Guo K, Dunford JE, Wu X, Knapp S, Ebetino FH, Rogers MJ, Russell RG, Oppermann U The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs PNAS, 2006, 103 (20): 7829-7834

 

Contact

udo [dot] oppermann[at]sgc [dot] ox [dot] ac [dot] uk (Prof. Udo Oppermann)

SGC
University of Oxford
Old Road Campus REsearch Building
Roosevelt Drive
Headington
Oxford
OX3 7DQ
UK

Phone: +44 1865 617585