Structure Gallery

Name: Activin receptor type-IIA (ACVR2A) kinase domain in complex with a beta-carboline inhibitor
PDB Code: 4ASX
Target Class: Protein Kinase
Target: ACVR2
Disease Area: cancer
Date Deposited: 2012-05-03

Name: Human ACACA C-terminal domain
PDB Code: 4ASI
Target Class: Miscellaneous
Target: ACACA
Disease Area: cancer
Date Deposited: 2012-05-01

Name: Kelch domain of human KBTBD5
PDB Code: 4ASC
Target Class: Miscellaneous
Target: KBTBD5
Disease Area:
Date Deposited: 2012-04-30

Name: NIMA (never in mitosis gene a)-related kinase 1
PDB Code: 4APC
Target Class: Non-protein Kinase
Target: NEK1
Disease Area: cancer
Date Deposited: 2012-04-02

Name: Human KLHL11-Cul3 complex at 2.8Å resolution
PDB Code: 4AP2
Target Class: Miscellaneous
Target: XX06CUL3
Disease Area:
Date Deposited: 2012-03-30

Name: Human Molybdopterin synthase catalytic subunit
PDB Code: 4AP8
Target Class: Miscellaneous
Target: MOCS2B
Disease Area:
Date Deposited: 2012-03-30

Name: Human Serine Threonine Kinase-10 (LOK) bound to GW830263A
PDB Code: 4AOT
Target Class: Protein Kinase
Target: STK10
Disease Area: cancer, signalling
Date Deposited: 2012-03-29

Name: Trypanosoma Brucei Adenylosuccinate Lyase, Tb427tmp.160.5560, in complex with AMP
PDB Code: 4EFC
Target Class: Transferases
Target: ASL
Disease Area: parasitic disease
Date Deposited: 2012-03-29

Name: Trypanosoma brucei M17 aminopeptidase, Tb427tmp.02.4440
PDB Code: 4EFD
Target Class: Proteases
Target: LeuAP
Disease Area: parasitic disease
Date Deposited: 2012-03-29

Name: Human plexin A4, Rho-GTPase binding domain
PDB Code: 4E74
Target Class: G-Protein Regulators
Target: PLXNA4
Disease Area: cancer, signalling
Date Deposited: 2012-03-16

Name: Human plexin B2, Rho-GTPase binding domain
PDB Code: 4E71
Target Class: G-Protein Regulators
Target: PLXNB2
Disease Area: signalling
Date Deposited: 2012-03-16

Name: Human SET domain containing (lysine methyltransferase) 7 in complex with inhibitor (R)-(3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide
PDB Code: 4E47
Target Class: Transferases
Target: SETD7
Disease Area: metabolism, chromatin and epigenetics
Date Deposited: 2012-03-12

Name: F-BAR domain of human FES tyrosine kinase
PDB Code: 4DYL
Target Class: Non-protein KinaseNucleotide metabolism
Target: FES
Disease Area: cancer, signalling
Date Deposited: 2012-02-29

Name: Human ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00135
PDB Code: 4DYM
Target Class: Non-protein KinaseNucleotide metabolism
Target: ACVR1
Disease Area: cancer, signalling
Date Deposited: 2012-02-29

Name: Human Sorting Nexin 33
PDB Code: 4AKV
Target Class: Miscellaneous
Target: SNX33
Disease Area:
Date Deposited: 2012-02-29

Name: Human cyclin-dependent kinase-like 1 (CDC2-related kinase)
PDB Code: 4AGU
Target Class: Proteases
Target: CDKL1
Disease Area: signalling
Date Deposited: 2012-01-31

Name: Human chromosome 14 open reading frame 169 NO66
PDB Code: 4DIQ
Target Class: Oxidoreductases
Target: FLJ21802
Disease Area: cancer, chromatin and epigenetics, signalling
Date Deposited: 2012-01-31

Name: Human peptidyl-prolyl cis-trans isomerase
PDB Code: 4DIP
Target Class: Miscellaneous
Target: FKBP14
Disease Area:
Date Deposited: 2012-01-31

Name: Human Aurora B Kinase in complex with INCENP and VX-680
PDB Code: 4AF3
Target Class: MiscellaneousProtein Kinase
Target: XX07AURKB
Disease Area:
Date Deposited: 2012-01-16

Name: Crystal structure of human LACTB2
PDB Code: 4AD9
Target Class: Miscellaneous
Target: LACTB2
Disease Area: cancer, metabolism
Date Deposited: 2011-12-22

Name: Human ubiquitin specific peptidase 2 in complex with ubiquitin-based inhibitor
PDB Code: 3V6E
Target Class: Ubiquitylation
Target: USP2
Disease Area: cancer, signalling
Date Deposited: 2011-12-19

Name: Human regulatory factor X-associated ankyrin-containing protein, ankyrin domain, in complex with RFX5 peptide
PDB Code: 3V30
Target Class: Miscellaneous
Target: RFXANK
Disease Area: signalling
Date Deposited: 2011-12-12

Name: Human ankyrin repeat, family A (RFXANK-like) 2, in complex with Megalin L peptide
PDB Code: 3V2O
Target Class: Miscellaneous
Target: ANKRA2
Disease Area: signalling
Date Deposited: 2011-12-12

Name: Human ankyrin repeat, family A (RFXANK-like) 2, in complex with HDAC4 peptide
PDB Code: 3V31
Target Class: Miscellaneous
Target: ANKRA2
Disease Area: signalling
Date Deposited: 2011-12-12

Name: Human ankyrin repeat, family A (RFXANK-like) 2, in complex with Megalin S peptide
PDB Code: 3V2X
Target Class: Miscellaneous
Target: ANKRA2
Disease Area: signalling
Date Deposited: 2011-12-12

Name: Full length Mouse STRAP (TTC5)
PDB Code: 4ABN
Target Class: Miscellaneous
Target: TTC5MMA
Disease Area:
Date Deposited: 2011-12-09

Name: Human tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide (14-3-3gamma), in complex with HDAC4 peptide
PDB Code: 3UZD
Target Class: Miscellaneous
Target: YWHAG
Disease Area: cancer
Date Deposited: 2011-12-07

Name: Jumonji domain of human Lysine-specific demethylase 8 (KDM8) in complex with N-oxalylglycine (NOG)
PDB Code: 4AAP
Target Class: Oxidoreductases
Target: FLJ13798
Disease Area:
Date Deposited: 2011-12-05

Name: Human regulatory factor X-associated ankyrin-containing protein, ankyrin domain, in complex with HDAC4 peptide
PDB Code: 3UXG
Target Class: Miscellaneous
Target: RFXANK
Disease Area: signalling
Date Deposited: 2011-12-05

Name: Human DOT1-like, histone H3 methyltransferase, in complex with 5-iodotubercidine
PDB Code: 3UWP
Target Class: Transferases
Target: DOT1L
Disease Area: cancer, chromatin and epigenetics
Date Deposited: 2011-12-02

Name: Human l(3)mbt-like 1, MBT domain, in complex with antagonist UNC1215
PDB Code: 3UWN
Target Class: Methyl-lysine readers
Target: L3MBTL1
Disease Area: cancer, chromatin and epigenetics
Date Deposited: 2011-12-02

Name: Human P63 Tetramerization 2 domain
PDB Code: 4A9Z
Target Class: Miscellaneous
Target: TP73L
Disease Area: cancer, signalling, neurobiology
Date Deposited: 2011-11-30

Name: Catalytic domain of the heterodimeric human soluble guanylate cyclase 1
PDB Code: 3UVJ
Target Class: Nucleotide metabolismSignalling proteins
Target: XX13GUCY1A3
Disease Area:
Date Deposited: 2011-11-30

Name: Human CDKL2 kinase domain
PDB Code: 4AAA
Target Class: Protein Kinase
Target: CDKL2
Disease Area:
Date Deposited: 2011-11-30

Name: Human Mitochondrial ABC Transporter, ABCB10 (plate form)
PDB Code: 4AA3
Target Class: Membrane proteins
Target: ABCB10
Disease Area:
Date Deposited: 2011-11-30

Name: Human BRD4 in complex with a diacetylated histone 4 peptide
PDB Code: 3UVW
Target Class: Bromodomain
Target: BRD4
Disease Area: cancer, chromatin and epigenetics, signalling
Date Deposited: 2011-11-30

Name: Human BRD4 in complex with a diacetylated histone 4 peptide
PDB Code: 3UVY
Target Class: Bromodomain
Target: BRD4
Disease Area: cancer, chromatin and epigenetics, signalling
Date Deposited: 2011-11-30

Name: Bromodomain of human nucleosome-remodeling factor subunit BPTF
PDB Code: 3UV2
Target Class: Bromodomain
Target: FALZ
Disease Area:
Date Deposited: 2011-11-29

Name: Second bromodomain of human Transcription initiation factor TFIID subunit 1 (TAF1)
PDB Code: 3UV4
Target Class: Bromodomain
Target: TAF1
Disease Area: cancer, signalling
Date Deposited: 2011-11-29

Name: tandem bromodomains of human Transcription initiation factor TFIID subunit 1 (TAF1)
PDB Code: 3UV5
Target Class: Bromodomain
Target: TAF1
Disease Area: cancer, signalling
Date Deposited: 2011-11-29

Name: Bromodomain of human Transcription activator BRG1 (SMARCA4) in complex with N-Methyl-2-pyrrolidone
PDB Code: 3UVD
Target Class: Bromodomain
Target: SMARCA4
Disease Area:
Date Deposited: 2011-11-29

Name: Human l(3)mbt-like 3, 3 MBT repeats
PDB Code: 3UT1
Target Class: Methyl-lysine readers
Target: L3MBTL3
Disease Area: chromatin and epigenetics
Date Deposited: 2011-11-24

Name: Human WD repeat domain 5 in complex with methyl 3-((3-methoxy-phenyl)-formylamino)-4-(4-methyl-piperazin-1-yl)-benzoate
PDB Code: 3UR4
Target Class: Miscellaneous
Target: WDR5
Disease Area: cancer, chromatin and epigenetics
Date Deposited: 2011-11-21

Name: Plasmodium falciparum guanine monophosphate synthetase (PF10_0123), in complex with GMP
PDB Code: 3UOW
Target Class: Transferases
Target: PfGMPS
Disease Area: parasitic disease
Date Deposited: 2011-11-17

Name: Human lamin B2, C-terminal IF-tail domain
PDB Code: 2LLL
Target Class: Miscellaneous
Target: LMNB2
Disease Area: signalling
Date Deposited: 2011-11-11

Name: Human cyclin D binding myb-like transcription factor 1, N-terminal myb-like 1 domain
PDB Code: 2LLK
Target Class: Miscellaneous
Target: DMTF1
Disease Area: signalling
Date Deposited: 2011-11-10

Name: Crystal Structure of human FABP9
PDB Code: 4A60
Target Class: Lipid signalling
Target: FABP9
Disease Area:
Date Deposited: 2011-10-31

Name: Crystal structure of the N-terminal domain of human Cul4B at 2.57Å resolution
PDB Code: 4A64
Target Class: Miscellaneous
Target: CUL4B
Disease Area:
Date Deposited: 2011-10-31

Name: Human p73-ASPP2 complex at 2.6 Å resolution
PDB Code: 4A63
Target Class: Miscellaneous
Target: XX01TP73
Disease Area:
Date Deposited: 2011-10-31

Name: First bromodomain of human BRD4 in complex with Alprazolam
PDB Code: 3U5J
Target Class: Bromodomain
Target: BRD4
Disease Area: cancer, chromatin and epigenetics, signalling
Date Deposited: 2011-10-11

Name: First bromodomain of human BRD4 in complex with Midazolam
PDB Code: 3U5K
Target Class: Bromodomain
Target: BRD4
Disease Area: cancer, chromatin and epigenetics, signalling
Date Deposited: 2011-10-11

Name: First bromodomain of human BRD4 in complex with a benzo-triazepine ligand (BzT-7)
PDB Code: 3U5L
Target Class: Bromodomain
Target: BRD4
Disease Area: cancer, chromatin and epigenetics, signalling
Date Deposited: 2011-10-11

Name: Human Glycogenin-1 (GYG1) complexed with manganese and glucose or a glucal species
PDB Code: 3U2W
Target Class: Miscellaneous
Target: GYG1
Disease Area:
Date Deposited: 2011-10-04

Name: Human Glycogenin-1 (GYG1) complexed with manganese, UDP and maltotetraose
PDB Code: 3U2U
Target Class: Miscellaneous
Target: GYG1
Disease Area:
Date Deposited: 2011-10-04

Name: Human Glycogenin-1 (GYG1) complexed with manganese, UDP and 1-deoxyglucose
PDB Code: 3U2X
Target Class: Miscellaneous
Target: GYG1
Disease Area:
Date Deposited: 2011-10-04

Name: Human Glycogenin-1 (GYG1) complexed with manganese
PDB Code: 3U2T
Target Class: Miscellaneous
Target: GYG1
Disease Area:
Date Deposited: 2011-10-04

Name: Human pyruvate kinase M2 in complex with activator
PDB Code: 3U2Z
Target Class: Non-protein Kinase
Target: PKM2
Disease Area: cancer
Date Deposited: 2011-10-04

Name: Human Glycogenin-1 (GYG1) complexed with manganese, UDP and maltohexaose
PDB Code: 3U2V
Target Class: Miscellaneous
Target: GYG1
Disease Area:
Date Deposited: 2011-10-04

Name: Human mitochondrial enolase superfamily member 1
PDB Code: 4A35
Target Class: Miscellaneous
Target: ENOSF1
Disease Area:
Date Deposited: 2011-09-30

Name: BAR domain of human Amphiphysin, isoform 1
PDB Code: 4ATM
Target Class: Miscellaneous
Target: AMPH
Disease Area:
Date Deposited: 2011-09-30

Name: Human RNA polymerase-associated protein RTF1 homolog, Plus-3 domain
PDB Code: 3U1U
Target Class: Methyl-lysine readers
Target: RTF1
Disease Area: chromatin and epigenetics
Date Deposited: 2011-09-30

Name: 2nd SH3 domain from Human CD2AP in complex with a proline-rich peptide from human RIN3
PDB Code: 3U23
Target Class: Miscellaneous
Target: CD2AP
Disease Area:
Date Deposited: 2011-09-30

Name: Human ubiquitin specific peptidase 37, pleckstrin homology domain
PDB Code: 3U12
Target Class: Ubiquitylation
Target: USP37
Disease Area: signalling
Date Deposited: 2011-09-29

Name: Human vesicle amine transporter VAT-1 homolog-like protein
PDB Code: 4A27
Target Class: Oxidoreductases
Target: KIAA1576
Disease Area:
Date Deposited: 2011-09-22

Name: Human mitochondrial endo-exonuclease
PDB Code: 4A1N
Target Class: Miscellaneous
Target: ENDOGL1
Disease Area: metabolism
Date Deposited: 2011-09-16

Name: Human itchy E3 ubiquitin protein ligase homolog, HECT domain
PDB Code: 3TUG
Target Class: Ubiquitylation
Target: ITCH
Disease Area: cancer
Date Deposited: 2011-09-16

Name: Crystal Structure of the Kinase Domain of ROR2
PDB Code: 3ZZW
Target Class: Protein Kinase
Target: ROR2
Disease Area: signalling
Date Deposited: 2011-09-05

Name: Human serine threonine kinase-10 bound to bosutinib-like compound
PDB Code: 3ZZ2
Target Class: Protein Kinase
Target: STK10
Disease Area: cancer, signalling
Date Deposited: 2011-08-31

Name: Human poly-bromodomain containing protein 1, fourth bromodomain
PDB Code: 3TLP
Target Class: Bromodomain
Target: PB1
Disease Area: cancer, chromatin and epigenetics, signalling
Date Deposited: 2011-08-30

Name: Plasmodium falciparum adenylate kinase (PF10_0086), in complex with ADP and ATP
PDB Code: 3TLX
Target Class: Non-protein Kinase
Target: Pf-AK
Disease Area: parasitic disease
Date Deposited: 2011-08-30

Name: Human glutaredoxin 3, first glutaredoxin domain
PDB Code: 3ZYW
Target Class: Oxidoreductases
Target: TXNL2
Disease Area: cancer, signalling
Date Deposited: 2011-08-29

Name: Human tandem VHS and FYVE domains of Hepatocyte growth factor-regulated tyrosine kinase substrate
PDB Code: 3ZYQ
Target Class: Miscellaneous
Target: HGS
Disease Area:
Date Deposited: 2011-08-24

Name: Human FYVE domain of endofin
PDB Code: 3T7L
Target Class: Miscellaneous
Target: ZFYVE16
Disease Area:
Date Deposited: 2011-07-30

Name: Human Glycogenin-1 in complex with manganese and UDP, in a triclinic closed form
PDB Code: 3T7M
Target Class: Miscellaneous
Target: GYG1
Disease Area:
Date Deposited: 2011-07-30

Name: Human Glycogenin-1 in complex with manganese and UDP, in a monoclinic closed form
PDB Code: 3T7N
Target Class: Miscellaneous
Target: GYG1
Disease Area:
Date Deposited: 2011-07-30

Name: Human Glycogenin-1 in complex with manganese, UDP-Glucose and glucose
PDB Code: 3T7O
Target Class: Miscellaneous
Target: GYG1
Disease Area:
Date Deposited: 2011-07-30

Name: Human glyoxalase domain-containing protein 5
PDB Code: 3ZW5
Target Class: Oxidoreductases
Target: GLOD5
Disease Area:
Date Deposited: 2011-07-28

Name: Human tRNase Z, short form
PDB Code: 3ZWF
Target Class: Miscellaneous
Target: ELAC1
Disease Area: cancer
Date Deposited: 2011-07-28

Name: Human DOT1-like histone H3 methyltransferase, in complex with Bromo-deaza-SAH
PDB Code: 3SX0
Target Class: Transferases
Target: DOT1L
Disease Area: cancer, chromatin and epigenetics
Date Deposited: 2011-07-15

Name: First bromodomain of human BRD4 in complex with a dihydro-quinazolin ligand
PDB Code: 3SVF
Target Class: Bromodomain
Target: BRD4
Disease Area: cancer, chromatin and epigenetics, signalling
Date Deposited: 2011-07-12

Name: First bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand
PDB Code: 3SVG
Target Class: Bromodomain
Target: BRD4
Disease Area: cancer, chromatin and epigenetics, signalling
Date Deposited: 2011-07-12

Name: Human CREB binding protein (bromodomain) in complex with a 3,5-dimethylisoxazol ligand
PDB Code: 3SVH
Target Class: Bromodomain
Target: CREBBP
Disease Area: cancer, metabolism, chromatin and epigenetics, signalling, neurobiology
Date Deposited: 2011-07-12

Name: Human activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin
PDB Code: 3SOC
Target Class: Protein Kinase
Target: ACVR2
Disease Area: cancer
Date Deposited: 2011-06-30

Name: 3rd PDZ domain of the human Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (MAGI3)
PDB Code: 3SOE
Target Class: PDZ linkers
Target: MAGI3
Disease Area: cancer
Date Deposited: 2011-06-30

Name: BAR domain of human amphiphysin, isoform 1 .
PDB Code: 3SOG
Target Class: Miscellaneous
Target: AMPH
Disease Area:
Date Deposited: 2011-06-30

Name: Human methylmalonyl aciduria type C with homocystinuria
PDB Code: 3SOM
Target Class: Miscellaneous
Target: MMACHC
Disease Area:
Date Deposited: 2011-06-30

Name: Human ankyrin repeat, family A (RFXANK-like), 2
PDB Code: 3SO8
Target Class: Miscellaneous
Target: ANKRA2
Disease Area: signalling
Date Deposited: 2011-06-29

Name: Human HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2, N-terminal domain
PDB Code: 2LFE
Target Class: Ubiquitylation
Target: HECW2
Disease Area: cancer
Date Deposited: 2011-06-29

Name: Human Poly (ADP-ribose) polymerase family, member 14 in complex with a quinazoline inhibitor
PDB Code: 3SMI
Target Class: Poly ADP-ribose polymerase
Target: PARP14
Disease Area: cancer
Date Deposited: 2011-06-28

Name: Human Poly (ADP-ribose) polymerase family, member 14 in complex with a pyrimidine-like inhibitor
PDB Code: 3SMJ
Target Class: Poly ADP-ribose polymerase
Target: PARP14
Disease Area: cancer
Date Deposited: 2011-06-28

Name: Human cytochrome P450, family 7, subfamily A, polypeptide 1, in complex with cholest-4-en-3-one
PDB Code: 3SN5
Target Class: Miscellaneous
Target: CYP7A1
Disease Area: metabolism
Date Deposited: 2011-06-28

Name: Human pantothenate kinase 3 in complex with a pantothenate analog
PDB Code: 3SMS
Target Class: Non-protein Kinase
Target: PANK3
Disease Area: metabolism
Date Deposited: 2011-06-28

Name: Human pantothenate kinase 1 in complex with acetyl-coA (monoclinic crystal)
PDB Code: 3SMP
Target Class: Non-protein Kinase
Target: PANK1
Disease Area: metabolism
Date Deposited: 2011-06-28

Name: Human SET domain containing 3 in complex with S-adenosyl-methionine
PDB Code: 3SMT
Target Class: Transferases
Target: SETD3
Disease Area: chromatin and epigenetics
Date Deposited: 2011-06-28

Name: Human eukaryotic translation initiation factor 4E, in complex with a 4EBP1 peptide complex, without cap
PDB Code: 3SMU
Target Class: G-Protein Regulators
Target: EIF4E
Disease Area: cancer
Date Deposited: 2011-06-28

Name: Human WD repeat domain 5 in complex with 2-chloro-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide
PDB Code: 3SMR
Target Class: Miscellaneous
Target: WDR5
Disease Area: chromatin and epigenetics
Date Deposited: 2011-06-28

Name: Human protein arginine methyltransferase 3 in complex with 1-(1,2,3-benzothiadiazol-6-yl)-3-[2-(cyclohexen-1-yl)ethyl]urea
PDB Code: 3SMQ
Target Class: Transferases
Target: PRMT3
Disease Area: chromatin and epigenetics
Date Deposited: 2011-06-28

Name: Human Poly (ADP-ribose) polymerase family, member 14 in complex with 6(5H)-phenanthridinone
PDB Code: 3SE2
Target Class: Poly ADP-ribose polymerase
Target: PARP14
Disease Area: cancer
Date Deposited: 2011-06-27

Name: Human metabotropic glutamate receptor 3, extracellular ligand binding domain, in complex with antagonist LY341495
PDB Code: 3SM9
Target Class: Membrane proteins
Target: GRM3
Disease Area: neurobiology
Date Deposited: 2011-06-27

Name: Human LIMK1 kinase domain in complex with staurosporine
PDB Code: 3S95
Target Class: Phosphoinosotide dependent signalling
Target: LIMK1
Disease Area: cancer
Date Deposited: 2011-05-31