Please contact us for any questions or request for reagents for this structure.

TULP1: Human Tubby-like protein 1, C-terminal domain

Click on the iSee icon to launch an enhanced annotation with interactive 3D representations and animated transitions. Please note that a web plugin (activeICM) is required to access this enhanced functionality. Instructions for the installation and use of the web plugin are available.

PDB Code 2FIM Target Class Phosphoinosotide dependent signalling Target TULP1 Alias RP14, TUBL1, TULP1 Disease Area/Function neurobiology Date Deposited Dec 29 2005 Authors B.M.HALLBERG, D.OGG, C.ARROWSMITH, H.BERGLUND, A.EDWARDS, M.EHN, S.FLODIN, S.GRASLUND, M.HAMMARSTROM, M.HOGBOM, L.HOLMBERG-SCHIAVONE, T.KOTENYOVA, P.KURSULA, P.NILSSON-EHLE, P.NORDLUND, T.NYMAN, J.SAGEMARK, P.STENMARK, M.SUNDSTROM, A.G.THORSELL, S.VAN DEN BERG, J.WEIGELT, C.PERSSON Related Structure 3C5N

About this structure

Monogenic murine obesity models are of value for pinpointing genetic causes for obesity. One murine obesity model is ‘tubby’ where the phenotype is characterized by increased body-weight at three to six months of age. Once the weight gain is induced it rapidly progresses and results in doubling of weight compared to controls. The phenotype is caused by an autosomal recessive mutation. Genetic approaches aimed at understanding the molecular basis for the tubby mouse phenotype revealed a family of four genes: the founding member TUB and three Tubby-like proteins (TULP1-3) that share significant sequence homology in a 260 residues long C-terminal domain. The C-terminal domain of TUB has been found to anchor in the membrane by binding to phosphatidylinositol-(4,5)-bisphosphate (PIP2). Upon cleavage of PIP2 by phospholipase C, a nuclear localization signal in the N-terminal part of TUB mediates transport into the nucleus. In the nucleus, TUB may regulate the transcription of one or several so far unknown genes.

We have also solved the structure of TULP1 in complex with IP3 (3C5N).