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Human TULP1 in complex with IP3

PDB Code 3C5N Target Class Phosphoinosotide dependent signalling Target TULP1 Alias RP14, TUBL1, TULP1 Disease Area/Function neurobiology Date Deposited Jan 31 2008 Authors R.D.BUSAM, L.LEHTIO, C.H.ARROWSMITH, R.COLLINS, L.G.DAHLGREN, A.EDWARDS, S.FLODIN, A.FLORES, S.GRASLUND, M.HAMMARSTROM, M.D.HERMAN, A.JOHANSSON, I.JOHANSSON, A.KALLAS, T.KARLBERG, T.KOTENYOVA, M.MOCHE, M.E.NILSSON, P.NORDLUND, T.NYMAN, C.PERSSON, J.SAGEMARK, L.SVENSSON, A.G.THORSELL, L.TRESAUGUES, S.VAN DEN BERG, M.WELIN, J.WEIGELT, H.BERGLUND, B.M.HALLBERG Related Structure 2FIM

About this structure

Monogenic murine obesity models are of value for pinpointing genetic causes for obesity. One murine obesity model is ‘tubby’ where the phenotype is characterized by increased body-weight at three to six months of age. Once the weight gain is induced it rapidly progresses and results in doubling of weight compared to controls. The phenotype is caused by an autosomal recessive mutation. Genetic approaches aimed at understanding the molecular basis for the tubby mouse phenotype revealed a family of four genes: the founding member TUB and three Tubby-like proteins (TULP1-3) that share significant sequence homology in a 260 residues long C-terminal domain. The C-terminal domain of TUB has been found to anchor in the membrane by binding to phosphatidylinositol-(4,5)-bisphosphate (PIP2). Upon cleavage of PIP2 by phospholipase C, a nuclear localization signal in the N-terminal part of TUB mediates transport into the nucleus. In the nucleus, TUB may regulate the transcription of one or several so far unknown genes.

This structure of TULP1 in complex with IP3 is a follow-up structure of 2FIM.