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Bromodomain of Human ATAD2B (AAA domain containing 2B)

PDB Code 3LXJ Target Class Bromodomain Target KIAA1240 Alias ATAD2B, KIAA1240, MGC88424 Disease Area/Function Date Deposited Feb 25 2010 Authors Filippakopoulos, P., Keates, T., Picaud, S., Fedorov, O., Krojer, T., Vollmar, M., Muniz, J., Pike, A.C.W., Von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Bountra, C., Knapp, S.

About this structure

p> KIAA1240, now called ATAD2B belongs to the family of AAA+ proteins, which are involved in a number of cellular processes ranging from protein degradation and DNA replication to membrane fusion and the movement of microtubule motors. AAA family proteins thereby often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.The hallmark of AAA (ATPases Associated with diverse cellular Activities) proteins is a 200-250 amino-acid ATP-binding domain (Hanson and Whiteheart, 2005). ATAD2B consists of one AAA+ domains and 1 bromodomain.

ATAD2B RNA has been detected in a wide variety of tissues indicating that this protein is widely expressed. So far nothing is known about the function of ATADB2 but the presence of the bromodomain hints towards a regulatory function in gene expression (Sanchez and Zhou, 2009). Here we report the structure of the Bromo domain of KIAA1240 at 2.3 Å resolution.

References

  1. Hanson, P.I., and Whiteheart, S.W. (2005). AAA+ proteins: have engine, will work. Nat Rev Mol Cell Biol 6, 519-529. PubMed 16072036
  2. Sanchez, R., and Zhou, M.M. (2009). The role of human bromodomains in chromatin biology and gene transcription. Curr Opin Drug Discov Devel 12, 659-665. PubMed 19736624