We are seeking an enthusiastic Postdoctoral Research Scientist to join our efforts in membrane protein structure determination. You will be responsible for all aspects of structural studies on membrane proteins, from construct design, protein purification, functional assays, to structure determination by single-particle cryo-EM or X-ray crystallography. You will be joining a team of highly collaborative scientists and use state-of-the-art facilities for protein production, X-ray crystallography and cryo-EM. These include the I24 microfocus beamline at Diamond Lightsource on the Harwell Oxford Campus, and cryo-EM facilities at the Oxford Particle Imaging Centre (OPIC) and the Central Oxford Structural Molecular Imaging Centre (COSMIC). These centres benefit from the recent installation of two Titan Krios microscopes with K2/energy filters, and additional screening microscopes with autoloaders (Talos Arctica and Glacios, each with Falcon III). In addition, our team is part of a Block Allocation Group to access the four Titan Krios data collection microscopes at the Electron Bio-Imaging Centre (eBIC) on Harwell Campus.
You should have a background in molecular biology, protein biochemistry or structural biology with a strong record of scientific publications. You will have/or be close to completing a PhD/DPhil, such as structural biology, membrane protein biochemistry, biophysics, molecular biology or a related field. Demonstrated expertise in protein expression, purification, functional characterisation and structure determination is essential. Prior experience with eukaryotic expression systems or large-scale production of recombinant membrane proteins for crystallisation/cryo-EM is desired.
You will be required to upload a CV and supporting statement which explains how you meet the selection criteria for the post.
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The closing date for applications is 12.00 noon on Friday 9 November 2018.
The SGC as part of the Nuffield Department of Medicine is a family friendly department: http://www.ndm.ox.ac.uk/family-friendly