SGC Oxford - Postdoctoral Scientist in Structural Biology

Applications are invited for a highly motivated Postdoctoral Scientist in Structural Biology to work within the Structural Genomic Consortium (SGC).

You will join an international, NIH-funded project (Open-AD) in developing a series of new therapeutic hypotheses centred around a prioritized set of novel targets in Alzheimer’s disease. Open-AD will develop a suite of target enabling tools including crystal structures, assays and chemical probes, and openly disseminate all data, methods and reagents to any interested academic and/or commercial investigator to accelerate validation of novel drug targets and to seed new drug discovery efforts.

You will manage, develop, establish, and pursue appropriate analytical protocols and techniques to support research. In particular, develop methods for expression and purification of the target proteins, structural analysis by crystallography, Cryo-EM and other methods, biochemical activity assays, and identification of ligands by screening and structure-guided approaches.

You will have a PhD (or close to completion) in Structural Biology or equivalent experience. You will have proven experience in protein biochemistry and crystallography or EM with an ability to plan and perform experiments independently. You will have demonstrable ability to organise and prioritize work efficiently whilst delivering results to the required standard and to an agreed schedule, with excellent communication skills in order to communicate effectively within a group, nationally and internationally with a wide range of people (at a variety of levels of technical knowledge).

The position is fixed-term for 2 years in the first instance and is funded by NIH.

Only applications received before 12.00 midday, on Monday, 16 March 2020 can be considered. Please quote reference 145359 on all correspondence.