We are seeking candidates for a Research Assistant position to join the Structural Genomics Consortium. We aim to promote the discovery of new drugs by investigating genes linked to human disease.
Genetic and sequencing studies are revealing a growing number of genes with clear links to human disease. Yet, in many cases, the role of these genes, the impact of mutations, and the relevance to future therapy is unclear. The SGC aims to decipher the function of genes involved in human disease using structural, biochemical, and chemical approaches. Our central activity is purification, crystallization and structure determination by X-ray crystallography. In parallel, we develop biochemical activity assays to study the function of the proteins, and (in selected cases) drive the development of small-molecule inhibitors to test the suitability of the proteins as drug targets. The SGC is committed to an open access policy, in which all our results are published and all reagents are made available without restrictions. The Genome Integrity group (headed by Dr Opher Gileadi) has focussed on genes involved in DNA repair and its regulation, but also on various other genes (often of unknown function) implicated in human diseases.
The successful candidate will have experience in recombinant protein expression, protein biochemistry, biochemical and cellular assays, or protein crystallisation. You will purify a variety of proteins, pursue crystallisation projects, will test the quality of the proteins and crystals, perform biophysical characterisation (e.g. mass spec, ITC), and perform activity assays. After learning the core techniques, you will be expected to drive the optimisation and development of research methods, and to help in tutoring new students and members of staff in your areas of expertise. The job involves use of sophisticated equipment and extensive electronic documentation.
The closing date for applications is 12.00 noon on Monday 20 August 2018.
The SGC as part of the Nuffield Department of Medicine is a family friendly department: http://www.ndm.ox.ac.uk/family-friendly