Date Posted: 23/09/2022
Faculty/Division: Temerty Faculty of Medicine
Department: Structural Genomics Consortium
Campus: St. George (Downtown Toronto)
Supervisor: Dr. Levon Halabelian
Home to over 40 departments and institutes, the University of Toronto's Temerty Faculty of Medicine lies at the heart of the Toronto Academic Health Science Network and is a global leader in ground-breaking research and education, spanning clinical medicine, basic science, and the rehabilitation sciences sectors.
The Structural Genomics Consortium (SGC) is an international Public-Private-Partnership that supports the discovery of new medicines through open access research (www.thesgc.org). Led from Toronto, the SGC is supported by public and philanthropic funding agencies and ten pharmaceutical industry partners. The SGC-Toronto Laboratory within the Temerty Faculty of Medicine, University of Toronto is offering several Postdoctoral positions (limited term) to join SGC’s structural biology team to investigate the structure, mechanism and druggability of several disease-related human proteins using X-ray crystallography, biochemistry and biophysics. We seek to develop chemical biology tools to elucidate the structure, function and therapeutic potential of select members of human proteins including Methyltransferases, Helicases, DNA and RNA nucleases, E3-ligases and deubiquitinases, among several others. This multidisciplinary project is in collaboration with academic labs as well as pharmaceutical companies. The successful candidate will have a broad knowledge of protein biochemistry and X-ray crystallography, a passion for scientific research as applied to drug discovery and be eager to work as a team player in a fast-paced multidisciplinary environment.
- Ph.D. in biochemistry, molecular biology, structural biology, or related field, with at least one first-authored publication in an internationally recognized peer-reviewed journal.
- Strong experience with recombinant protein expression and purification is required.
- Experience in X-ray crystallography and/or cryo-EM is highly desirable.
- Experience within vitro biophysical methods for protein-protein and protein-ligand interaction studies (e.g. DSF, SPR, FP, FRET, ITC) is an asset.
- Strong communication skills, particularly the visual presentation of structural data.
- Ability to work in a team, communicate and give/receive constructive feedback.
- High attention to detail, excellent organizational and documentation skills.
- Experience in preparing manuscripts for submission to peer review publications/journals and presenting findings at meetings and conferences.
APPLICATIONS SHOULD BE SENT TO: [email@example.com] with the subject line “SGC Postdoc in Structural Biology”
The University of Toronto and its affiliated hospital research institutes comprise one of the largest and most productive centers of biomedical research in North America. Located in vibrant downtown Toronto, the University provides an outstanding opportunity for scientific research, and career development.
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