UNIVERSITY OF TORONTO
POSITION TITLE: Postdoctoral Position – Limited Term
DEPARTMENT: Structural Genomics Consortium (SGC), Faculty of Medicine
SUPERVISOR: Dr. Levon Halabelian
The Structural Genomics Consortium (SGC) in the Faculty of Medicine, University of Toronto invites applications for the Postdoctoral position (Limited Term) to join the SGC’s structural biology team to investigate the structure, mechanism and druggability of human WD-repeat (WDR) domain containing proteins using X-ray crystallography, biochemistry and biophysics. WDRs are protein-protein interaction hubs that are often found in key regulatory complexes involved in ribosomal biogenesis, epigenetic regulation, cell cycle control and DNA repair (see Schapira et al., 2017, https://doi.org/10.1038/nrd.2017.179), (Grebien et al, 2015, https://doi.org/10.1038/nchembio.1859) and (Getlik et al., 2016, DOI: 10.1021/acs.jmedchem.5b01630).
Many WDR proteins are associated with diverse neurodegenerative diseases including Parkinson’s Disease (PD), Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD) and others. This project focuses on understanding the role of LRRK2 WDR domain in PD including disease-linked mutations and its potential for therapeutic modulation.
The successful candidate will have a broad knowledge of protein biochemistry and X-ray crystallography, a passion for scientific research as applied to drug discovery and be eager to work as a team player in a fast-paced multidisciplinary environment.
· Ph.D. in biochemistry, molecular biology, structural biology, or related field, with at least one first authored publication in an internationally recognised peer-reviewed journal.
· Strong experience with recombinant protein expression, and purification, is required.
· Experience in X-ray crystallography and/or cryo-EM is highly desirable.
· Experience with in vitro biophysical methods for protein-protein and protein-ligand interaction studies (e.g. DSF, SPR, FP, FRET and ITC) is valuable.
· Strong communication skills, particularly the visual presentation of structural data.
· Ability to work in a team, communicate, and give/receive constructive feedback and high attention to detail, excellent organizational and documentation skills.
· Experience in preparing manuscripts for submission to peer review publications/journals and presenting findings at meetings and conferences.
APPLICATIONS SHOULD BE SENT TO: email@example.com with the subject line “WDR Postdoc”. Position will remain open until filled.
About Structural Genomics Consortium The Structural Genomics Consortium (SGC) (https://www.thesgc.org/) is a global public private partnership dedicated to open science and that seeks to accelerate drug discovery by fostering collaboration among a large network of scientists in academia and industry and by making all research outputs openly available to the scientific community. The current SGC research hubs are in Canada, Germany, Sweden, the United Kingdom, and the United States.
The University of Toronto and its affiliated hospital research institutes comprise one of the largest and most productive centers of biomedical research in North America. Located in vibrant downtown Toronto, the University provides an outstanding opportunity for scientific research, and career development.
The University of Toronto is strongly committed to diversity within its community and especially welcomes applications from racialized persons / persons of colour, women, Indigenous / Aboriginal People of North America, persons with disabilities, LGBTQ persons, and others who may contribute to the further diversification of ideas.
All qualified incumbents are encouraged to apply; however, Canadians and permanent residents will be given priority.
The SGC as part of the Nuffield Department of Medicine is a family friendly department: http://www.ndm.ox.ac.uk/family-friendly