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►Discovery of potent, selective, cell-active chemical probes for epigenetic targets using innovative methods. Identification of new templates for optimization by the use of fragment screening and focussed library design.
The goal of the Epigenetic Chemical Probes group is to identify small molecules which interact with epigenetic targets with the following properties:-
- IC50 (inhibitors) or Kd (antagonists) < 100nM.
- >30-fold selectivity over targets in different branches of the phylogenetic tree, and other target families.
- significant activity in cells < 1 mM.
- the co-crystal structure of the ligand and protein is solved to better than 2.8A resolution.
- the chemical probe is widely available to the scientific community without restrictions on use.
Group Members
Hong received her Ph.D. in biochemistry from Dalhousie University and had her postdoctoral training at University of Torontowith Dr. Lori Frappier. Hong then joined a Toronto-based biotech company as a scientist in the department of protein/antibody engineering, focused on generating recombinant antibodies for various biomarkers. In 2004, Hong joined the SGC. As the team-leader, Hong and her team have focused on solving crystal structures of human histone modification enzymes. Hong’s research interests include using structural and biochemical methods to study the molecular mechanism of epigenetic regulation of gene expression.
Group Publications
2011
J. Med. Chem.. 08.09.2011 54(17):6139-50. doi: 10.1021/jm200903z
PMID: 21780790
Nat. Chem. Biol.. 10.07.2011 7(8):566-74. doi: 10.1038/nchembio.599
PMID: 21743462
J. Med. Chem.. 14.04.2011 54(7):2504-11. doi: 10.1021/jm200045v
PMID: 21417280
2010
J. Med. Chem.. 12.08.2010 53(15):5844-57. doi: 10.1021/jm100478y
PMID: 20614940
Chem. Biol.. 30.07.2010 17(7):695-704. doi: 10.1016/j.chembiol.2010.04.014
PMID: 20659682
2009
J. Med. Chem.. 24.12.2009 52(24):7950-3. doi: 10.1021/jm901543m
PMID: 19891491