Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction

Leucine-rich repeat kinase 2 (LRRK2) is the most commonly mutated gene in familial Parkinson’s disease (PD) and is also linked to its idiopathic form. LRRK2 is proposed to function in membrane trafficking and co-localizes with microtubules. Despite LRRK2’s fundamental importance for understanding and treating PD, there is limited structural information on it.