Wyatt Yue is a structural biologist with an MA (Biochemistry) at University of Oxford, and a PhD (Crystallography) at Birkbeck College, University of London. He pursued a postdoc fellowship in Institute of Cancer Research with Prof Laurence Pearl FRS, followed by a stint at the fragment-based drug discovery company Sareum Ltd. In 2008 he joined the Structural Genomics Consortium (SGC), University of Oxford as a Senior Scientist in high throughput protein structure determination. In 2012 he established his own research team ‘Metabolism & Organelle Biogenesis (MOB)’ at the SGC, using structural, biochemical, and chemical biology approaches to study diverse metabolic protein families in the human genome. He specialises in the use of protein structures and biochemistry to understand the molecular basis of human inherited diseases. He collaborates with front line clinicians and industry for the development of small molecule therapy for rare diseases.
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The Metabolism & Organelle Biogenesis (MOB) group combines structural, biochemical, and chemical biology approaches to study the functions and structure-activity relationships of diverse metabolic protein families in the human genome, with emphasis on understanding the molecular basis of inherited metabolic disorders and potentials of small molecule therapeutics. Research activities in the group include the heterologous expression, chromatography purification, biophysical characterization and crystal structure determination of human metabolic enzymes of medical interest. Current areas of focus include: multiprotein complex machines, glycogen synthesis, vitamin B12 metabolism and Leloir pathway of galactose metabolism.
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