Wyatt Yue is a structural biologist with an MA (Biochemistry) from University of Oxford, and a PhD (Crystallography) from Birkbeck College, University of London. He pursued a postdoc fellowship in Institute of Cancer Research with Prof Laurence Pearl FRS, followed by a stint at the fragment-based drug discovery company Sareum Ltd. In 2008 he joined the Structural Genomics Consortium (SGC), University of Oxford as a Senior Scientist in high throughput protein structure determination. In 2012 he established his own research team ‘Metabolism & Organelle Biogenesis (MOB)’ at the SGC, and in 2015 he was conferred Associate Professorship at the Nuffield Department of Medicine.
He specializes in the use of structural, biochemical and chemical biology approaches to study diverse metabolic protein families in the human genome, with the aim of deciphering the molecular mechanism of human inherited diseases at the protein level. His team has to date deposited >130 human crystals structures in the Protein Data Bank (PDB). Through collaborations with clinicians and pharma partners, his team aims to translate basic science into design of small molecule therapeutics for rare diseases with unmet need.
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The Metabolism & Organelle Biogenesis (MOB) group combines structural, biochemical, and chemical biology approaches to study the functions and structure-activity relationships of diverse metabolic protein families in the human genome, with emphasis on understanding the molecular basis of inherited metabolic disorders and potentials of small molecule therapeutics. Research activities in the group include the heterologous expression, chromatography purification, biophysical characterization and crystal structure determination of human metabolic enzymes of medical interest. Current areas of focus include: multiprotein complex machines, glycogen synthesis, vitamin B12 metabolism and Leloir pathway of galactose metabolism.
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