S Roham
Sandra Röhm

Principal Investigator

Frankfurt

Sandra Röhm studied Biomedicinal Chemistry at the Johannes Gutenberg University and at the Max Planck Institute for Polymer Research in Mainz. For her scientific achievements in the field of Chemistry, she was awarded with the Adolf Todt prize from the University of Mainz. In 2015 she joined Professor Stefan Knapp‘s group and the Structural Genomics Consortium in Frankfurt. During her Ph.D. studies, she successfully developed chemical probes targeting the mitogen activated protein kinase p38 and the discoidin domain receptor kinase. In 2020 she continued as a postdoc and worked on kinase inhibitors for Parkinson's disease. As leader of WP2 in the EUbOPEN Consortium, she is coordinating the effort to generate a chemogenomic compound library. Together with her team, her current research interests focus on the design of covalent and allosteric inhibitors with structural novelties.

Publicatons SRohm

Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe.
Röhm S, Berger BT, Schröder M, Chatterjee D, Mathea S, Joerger AC, Pinkas DM, Bufton JC, Tjaden A, Kovooru L, Kudolo M, Pohl C, Bullock AN, Müller S, Laufer S, Knapp S
J Med Chem. 2021 . doi: 10.1021/acs.jmedchem.1c00868
PMID: 34506142

Selective targeting of the αC and DFG-out pocket in p38 MAPK.
Röhm S, Schröder M, Dwyer JE, Widdowson CS, Chaikuad A, Berger BT, Joerger AC, Krämer A, Harbig J, Dauch D, Kudolo M, Laufer S, Bagley MC, Knapp S
Eur J Med Chem. 2020 208:112721. doi: 10.1016/j.ejmech.2020.112721
PMID: 33035818

A fast iterative synthetic approach towards the identification of novel highly selective p38 MAP kinase inhibitors.
Röhm S, Berger BT, Schröder M, Chaikuad A, Winkel R, Hekking KFW, Benningshof JJC, Mueller G, Tesch R, Kudolo M, Forster M, Laufer SA, Knapp S
J. Med. Chem.. 2019 . doi: 10.1021/acs.jmedchem.9b01227
PMID: 31702918

2023

Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum.
Tredup C, Ndreshkjana B, Schneider NS, Tjaden A, Kemas AM, Youhanna S, Lauschke VM, Berger BT, Krämer A, Berger LM, Röhm S, Knapp S, Farin HF, Müller S
ACS Chem Biol. 21.03.2023 . doi: 10.1021/acschembio.2c00877
PMID: 36944371

2022

A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins.
Schwalm MP, Berger LM, Meuter MN, Vasta JD, Corona CR, Röhm S, Berger BT, Farges F, Beinert SM, Preuss F, Morasch V, Rogov VV, Mathea S, Saxena K, Robers MB, Müller S, Knapp S
Front Cell Dev Biol. 21.06.2022 10:886537. doi: 10.3389/fcell.2022.886537
PMID: 35721509

2021

Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe.
Röhm S, Berger BT, Schröder M, Chatterjee D, Mathea S, Joerger AC, Pinkas DM, Bufton JC, Tjaden A, Kovooru L, Kudolo M, Pohl C, Bullock AN, Müller S, Laufer S, Knapp S
J Med Chem. 10.09.2021 . doi: 10.1021/acs.jmedchem.1c00868
PMID: 34506142

2020

Selective targeting of the αC and DFG-out pocket in p38 MAPK.
Röhm S, Schröder M, Dwyer JE, Widdowson CS, Chaikuad A, Berger BT, Joerger AC, Krämer A, Harbig J, Dauch D, Kudolo M, Laufer S, Bagley MC, Knapp S
Eur J Med Chem. 20.08.2020 208:112721. doi: 10.1016/j.ejmech.2020.112721
PMID: 33035818

Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate.
Schuhmacher MK, Beldar S, Khella MS, Bröhm A, Ludwig J, Tempel W, Weirich S, Min J, Jeltsch A
Commun Biol. 16.09.2020 3(1):511. doi: 10.1038/s42003-020-01223-6
PMID: 32939018

2019

A fast iterative synthetic approach towards the identification of novel highly selective p38 MAP kinase inhibitors.
Röhm S, Berger BT, Schröder M, Chaikuad A, Winkel R, Hekking KFW, Benningshof JJC, Mueller G, Tesch R, Kudolo M, Forster M, Laufer SA, Knapp S
J. Med. Chem.. 08.11.2019 . doi: 10.1021/acs.jmedchem.9b01227
PMID: 31702918

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