Wyatt Yue

Principal Investigator / Associate Professor

University of Oxford

Twitter: @YueLabSGC

+44 (0)1865 617757

Wyatt Yue is a structural biologist with an MA (Biochemistry) from University of Oxford, and a PhD (Crystallography) from Birkbeck College, University of London. He pursued a postdoc fellowship in Institute of Cancer Research with Prof Laurence Pearl FRS, followed by a stint at the fragment-based drug discovery company Sareum Ltd. In 2008 he joined the Structural Genomics Consortium (SGC), University of Oxford as a Senior Scientist in high throughput protein structure determination. In 2012 he established his own research team ‘Metabolism & Organelle Biogenesis (MOB)’ at the SGC, and in 2015 he was conferred Associate Professorship at the Nuffield Department of Medicine.

He specializes in the use of structural, biochemical and chemical biology approaches to study diverse metabolic protein families in the human genome, with the aim of deciphering the molecular mechanism of human inherited diseases at the protein level. His team has to date deposited >200 human crystals structures in the Protein Data Bank (PDB). Through collaborations with clinicians and pharma partners, his team aims to translate basic science into design of small molecule therapeutics for rare diseases with unmet need. 

Wyatt is featured in:

Research Areas

The Metabolism & Organelle Biogenesis (MOB) group combines structural, biochemical, and chemical biology approaches to study the functions and structure-activity relationships of diverse metabolic protein families in the human genome, with emphasis on understanding the molecular basis of inherited metabolic disorders and potentials of small molecule therapeutics. Research activities in the group include the heterologous expression, chromatography purification, biophysical characterization and crystal structure determination of human metabolic enzymes of medical interest. Current areas of focus include: multiprotein complex machines, glycogen synthesis, vitamin B12 metabolism and Leloir pathway of galactose metabolism.

Our mission statement:
  • We explore how genetic defects lead to disease at the molecular level, by determining the structural and biochemical properties of enzymes and protein complexes linked to genetic errors.
  • We work closely with clinicians, pharmaceutical partners and patient groups to decipher the underlying genetic, biochemical and cellular mechanisms of these diseases.
  • Our long-term goal is to design novel small molecule therapeutic approaches focussing on two challenging concepts, namely diseases associated with loss of function, and protein-protein interactions.

See our structure gallery

Publications

Structural insight into the human mitochondrial tRNA purine N1-methyltransferase and Ribonuclease P complexes.
Oerum S, Roovers M, Rambo RP, Kopec J, Bailey HJ, Fitzpatrick F, Newman JA, Newman WG, Amberger A, Zschocke J, Droogmans L, Oppermann U, Yue WW
J. Biol. Chem.. 2018 . doi: 10.1074/jbc.RA117.001286
PMID: 29880640

Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition.
Froese DS, Kopec J, Rembeza E, Bezerra GA, Oberholzer AE, Suormala T, Lutz S, Chalk R, Borkowska O, Baumgartner MR, Yue WW
Nat Commun. 2018 9(1):2261. doi: 10.1038/s41467-018-04735-2
PMID: 29891918

The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery.
Bradley AR, Echalier A, Fairhead M, Strain-Damerell C, Brennan P, Bullock AN, Burgess-Brown NA, Carpenter EP, Gileadi O, Marsden BD, Lee WH, Yue W, Bountra C, von Delft F
Essays Biochem.. 2017 61(5):495-503. doi: 10.1042/EBC20170051
PMID: 29118096

Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis
Montgomery, AB; Kopec, J; Shrestha, L; Thezenas, M-L; Burgess-Brown, NA; Fischer, R; Yue, WW; Venables, PJ;
Annals of the Rheumatic Diseases. 2016 75:1255-1261. doi: 10.1136/annrheumdis-2015-207656
PMID:

Molecular basis of classic galactosemia from the structure of human galactose 1-phosphate uridylyltransferase.
McCorvie TJ, Kopec J, Pey AL, Fitzpatrick F, Patel D, Chalk R, Streetha L, Yue WW
Hum. Mol. Genet.. 2016 . doi: 10.1093/hmg/ddw091
PMID: 27005423

Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design.
Froese DS, Michaeli A, McCorvie TJ, Krojer T, Sasi M, Melaev E, Goldblum A, Zatsepin M, Lossos A, Álvarez R, Escribá PV, Minaissan BA, von Delft F, Kakhlon O, Yue WW
Hum. Mol. Genet.. 2015 . doi: 10.1093/hmg/ddv280
PMID: 26199317

Inter-domain communication of human cystathionine β-synthase: structural basis of S-adenosyl-L-methionine activation.
McCorvie, TJ; Kopec, J; Hyung, S-J; Fitzpatrick, F; Feng, X; Termine, D; Strain-Damerell, C; Vollmar, M; Fleming, J; Janz, JM; Bulawa, C; Yue, WW;
Journal of Biological Chemistry. 2014 289:36018-36030. doi: 10.1074/jbc.M114.610782
PMID: 25336647

Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations.
Froese DS, Forouhar F, Tran TH, Vollmar M, Kim YS, Lew S, Neely H, Seetharaman J, Shen Y, Xiao R, Acton TB, Everett JK, Cannone G, Puranik S, Savitsky P, Krojer T, Pilka ES, Kiyani W, Lee WH, Marsden BD, von Delft F, Allerston CK, Spagnolo L, Gileadi O, Montelione GT, Oppermann U, Yue WW, Tong L
Structure. 2013 . doi: 10.1016/j.str.2013.05.001
PMID: 23791943

Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.
Chaikuad A, Froese DS, Berridge G, von Delft F, Oppermann U, Yue WW
Proc. Natl. Acad. Sci. U.S.A.. 2011 108(52):21028-33. doi: 10.1073/pnas.1113921108
PMID: 22160680

Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation.
Froese DS, Kochan G, Muniz JR, Wu X, Gileadi C, Ugochukwu E, Krysztofinska E, Gravel RA, Oppermann U, Yue WW
J. Biol. Chem.. 2010 285(49):38204-13. doi: 10.1074/jbc.M110.177717
PMID: 20876572

2020

Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop regulating substrate binding and product release
Bailey HJ, Bezerra GA, Marcero JR, Padhi S, Foster WR, Rembeza E, Roy A, Bishop DF, Desnick RJ, Bulusu G, Dailey HA, Yue WW
Nature Communications. 2020 11:2813-. doi: 10.1038/s41467-020-16586-x
PMID: 32499479

2019

The natural history of infantile mitochondrial DNA depletion syndrome due to RRM2B deficiency
Keshavan N, Abdenur J, Anderson G, Assouline Z, Barcia G, Bouhikbar L, Chakrapani A, Cleary M, Cohen MC, Feillet F, Fratter C, Hauser N, Jacques T, Lam A, McCullagh H, Phadke R, Rötig A, Sharrard M, Simon M, Smith C, Sommerville EW, Taylor RW, Yue WW, Rahman S
Genetics in Medicine. 2019 . doi: 10.1038/s41436-019-0613-z
PMID: 31462754

Expanding the genetic and phenotypic spectrum of branched-chain amino acid transferase 2 deficiency
Knerr I, Colombo R, Urquhart J, Morais A, Merinero B, Oyarzabal A, Pérez B, Jones SA, Perveen R, Preece MA, Rogers Y, Treacy EP, Mayne P, Zampino G, MacKinnon S, Wassmer E, Yue WW, Robinson I, Rodríguez-Pombo P, Olpin SE, Banka S
Journal of Inherited Metabolic Disease. 2019 42:809-817. doi: 10.1002/jimd.12135
PMID: 31177572

Genetic, structural, and functional analysis of pathogenic variations causing methylmalonyl-CoA epimerase deficiency
Heuberger K, Bailey HJ, Burda P, Chaikuad A, Krysztofinska E, Suormala T, Bürer C, Lutz S, Fowler B, Froese DS, Yue WW, Baumgartner MR
Biochimica et Biophysica Acta - Molecular Basis of Disease. 2019 1865:1265-1272. doi: 10.1016/j.bbadis.2019.01.021
PMID: 30682498

15-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism.
Abis G, Charles RL, Kopec J, Yue WW, Atkinson RA, Bui TTT, Lynham S, Popova S, Sun YB, Fraternali F, Eaton P, Conte MR
Commun Biol. 2019 2:188. doi: 10.1038/s42003-019-0426-2
PMID: 31123712

Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism
Fox NG, Yu X, Feng X, Bailey HJ, Martelli A, Nabhan JF, Strain-Damerell C, Bulawa C, Yue WW, Han S
Nature Communications. 2019 10:2210-. doi: 10.1038/s41467-019-09989-y
PMID: 31101807

Identification of a novel biomarker for pyridoxine-dependent epilepsy: Implications for newborn screening
Wempe MF, Kumar A, Kumar V, Choi YJ, Swanson MA, Friederich MW, Hyland K, Yue WW, Van Hove JLK, Coughlin CR
Journal of Inherited Metabolic Disease. 2019 42:565-574. doi: 10.1002/jimd.12059
PMID: 30663059

Role of protein structure in variant annotation: structural insight of mutations causing 6-pyruvoyl-tetrahydropterin synthase deficiency
Muniz JRC, Szeto NW-S, Frise R, Lee WH, Wang X-S, Thöny B, Himmelreich N, Blau N, Hsiao K-J, Liu T-T, Gileadi O, Oppermann U, Von Delft F, Yue WW, Tang NL-S
Pathology. 2019 51:274-280. doi: 10.1016/j.pathol.2018.11.011
PMID: 30853107

Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder.
Roberts NA, Hilton EN, Lopes FM, Singh S, Randles MJ, Gardiner NJ, Chopra K, Coletta R, Bajwa Z, Hall RJ, Yue WW, Schaefer F, Weber S, Henriksson R, Stuart HM, Hedman H, Newman WG, Woolf AS
Kidney Int.. 2019 . doi: 10.1016/j.kint.2018.11.040
PMID: 30885509

4'-Phosphopantetheine and long acyl chain-dependent interactions are integral to human mitochondrial acyl carrier protein function.
Majmudar JD, Feng X, Fox NG, Nabhan JF, Towle T, Ma T, Gooch R, Bulawa C, Yue WW, Martelli A
Medchemcomm. 2019 10(2):209-220. doi: 10.1039/c8md00489g
PMID: 30881609

2018

Arginine does not rescue p.Q188R mutation deleterious effect in classic galactosemia.
Haskovic M, Derks B, van der Ploeg L, Trommelen J, Nyakayiru J, van Loon LJC, Mackinnon S, Yue WW, Peake RWA, Zha L, Demirbas D, Qi W, Huang X, Berry GT, Achten J, Bierau J, Rubio-Gozalbo ME, Coelho AI
Orphanet J Rare Dis. 2018 13(1):212. doi: 10.1186/s13023-018-0954-8
PMID: 30477550

Oxidation resistance 1 regulates post-translational modifications of peroxiredoxin 2 in the cerebellum.
Svistunova DM, Simon JN, Rembeza E, Crabtree M, Yue WW, Oliver PL, Finelli MJ
Free Radic. Biol. Med.. 2018 . doi: 10.1016/j.freeradbiomed.2018.10.447
PMID: 30389497

Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis.
Bilyard MK, Bailey HJ, Raich L, Gafitescu MA, Machida T, Iglésias-Fernández J, Lee SS, Spicer CD, Rovira C, Yue WW, Davis BG
Nature. 2018 . doi: 10.1038/s41586-018-0644-7
PMID: 30356213

Guaiacol as a drug candidate for treating adult polyglucosan body disease.
Kakhlon O, Ferreira I, Solmesky LJ, Khazanov N, Lossos A, Alvarez R, Yetil D, Pampou S, Weil M, Senderowitz H, Escriba P, Yue WW, Akman HO
JCI Insight. 2018 3(17):. doi: 10.1172/jci.insight.99694
PMID: 30185673

Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity.
Fox NG, Martelli A, Nabhan JF, Janz J, Borkowska O, Bulawa C, Yue WW
Biochimie. 2018 . doi: 10.1016/j.biochi.2018.07.012
PMID: 30031876

Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition.
Froese DS, Kopec J, Rembeza E, Bezerra GA, Oberholzer AE, Suormala T, Lutz S, Chalk R, Borkowska O, Baumgartner MR, Yue WW
Nat Commun. 2018 9(1):2261. doi: 10.1038/s41467-018-04735-2
PMID: 29891918

Structural insight into the human mitochondrial tRNA purine N1-methyltransferase and Ribonuclease P complexes.
Oerum S, Roovers M, Rambo RP, Kopec J, Bailey HJ, Fitzpatrick F, Newman JA, Newman WG, Amberger A, Zschocke J, Droogmans L, Oppermann U, Yue WW
J. Biol. Chem.. 2018 . doi: 10.1074/jbc.RA117.001286
PMID: 29880640

Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment.
Bulbrook, D; Brazier, H; Mahajan, P; Kliszczak, M; Fedorov, O; Marchese, FP; Aubareda, A; Chalk, R; Picaud, S; Strain-Damerell, C; Filippakopoulos, P; Gileadi, O; Clark, AR; Yue, WW; Burgess-Brown, NA; Dean, JLE;
Journal of Molecular Biology. 2018 430:722-736. doi: 10.1016/j.jmb.2017.12.018
PMID: 29291391

Nbeal2 interacts with Dock7, Sec16a, and Vac14.
Mayer, L; Jasztal, M; Pardo, M; Aguera de Haro, S; Collins, J; Bariana, TK; Smethurst, PA; Grassi, L; Petersen, R; Nurden, P; Favier, R; Yu, L; Meacham, S; Astle, WJ; Choudhary, J; Yue, WW; Ouwehand, WH; Guerrero, JA;
Blood. 2018 131:1000-1011. doi: 10.1182/blood-2017-08-800359
PMID: 29187380

2017

The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery.
Bradley AR, Echalier A, Fairhead M, Strain-Damerell C, Brennan P, Bullock AN, Burgess-Brown NA, Carpenter EP, Gileadi O, Marsden BD, Lee WH, Yue W, Bountra C, von Delft F
Essays Biochem.. 2017 61(5):495-503. doi: 10.1042/EBC20170051
PMID: 29118096

IDUA mutational profile and genotype-phenotype relationships in UK patients with Mucopolysaccharidosis Type I.
Ghosh, A; Mercer, J; Mackinnon, S; Yue, WW; Church, H; Beesley, CE; Broomfield, A; Jones, SA; Tylee, K;
Human Mutation. 2017 38:1555-1568. doi: 10.1002/humu.23301
PMID: 28752568

RAC1 Missense Mutations in Developmental Disorders with Diverse Phenotypes.
Reijnders MRF, Ansor NM, Kousi M, Yue WW, Tan PL, Clarkson K, Clayton-Smith J, Corning K, Jones JR, Lam WWK, Mancini GMS, Marcelis C, Mohammed S, Pfundt R, Roifman M, Cohn R, Chitayat D, Millard TH, Katsanis N, Brunner HG, Banka S
Am. J. Hum. Genet.. 2017 101(3):466-477. doi: 10.1016/j.ajhg.2017.08.007
PMID: 28886345

Novel patient missense mutations in the HSD17B10 gene affect dehydrogenase and mitochondrial tRNA modification functions of the encoded protein.
Oerum S, Roovers M, Leichsenring M, Acquaviva-Bourdain C, Beermann F, Gemperle-Britschgi C, Fouilhoux A, Korwitz-Reichelt A, Bailey HJ, Droogmans L, Oppermann U, Sass JO, Yue WW
Biochim. Biophys. Acta. 2017 . doi: 10.1016/j.bbadis.2017.09.002
PMID: 28888424

A novel image-based high-throughput screening assay discovers therapeutic candidates for adult polyglucosan body disease.
Solmesky, LJ; Khazanov, N; Senderowitz, H; Wang, P; Minassian, BA; Ferreira, IM; Yue, WW; Lossos, A; Weil, M; Kakhlon, O;
Biochemical Journal. 2017 474:3403-3420. doi: 10.1042/BCJ20170469
PMID: 28827282

The origin and evolution of human glutaminases and their atypical C-terminal ankyrin repeats.
Pascoal CC, Islam Z, Adamoski D, Ferreira IM, Righetto RD, Bettini J, Portugal RV, Yue WW, Gonzalez A, Dias SMG, Ambrosio ALB
J. Biol. Chem.. 2017 . doi: 10.1074/jbc.M117.787291
PMID: 28526749

2016

Advantages and pitfalls of an extended gene panel for investigating complex neurometabolic phenotypes.
Reid ES, Papandreou A, Drury S, Boustred C, Yue WW, Wedatilake Y, Beesley C, Jacques TS, Anderson G, Abulhoul L, Broomfield A, Cleary M, Grunewald S, Varadkar SM, Lench N, Rahman S, Gissen P, Clayton PT, Mills PB
Brain. 2016 . doi: 10.1093/brain/aww221
PMID: 27604308

Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis
Montgomery, AB; Kopec, J; Shrestha, L; Thezenas, M-L; Burgess-Brown, NA; Fischer, R; Yue, WW; Venables, PJ;
Annals of the Rheumatic Diseases. 2016 75:1255-1261. doi: 10.1136/annrheumdis-2015-207656
PMID:

Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain.
Patel D, Kopec J, Fitzpatrick F, McCorvie TJ, Yue WW
Sci Rep. 2016 6:23748. doi: 10.1038/srep23748
PMID: 27049649

Molecular basis of classic galactosemia from the structure of human galactose 1-phosphate uridylyltransferase.
McCorvie TJ, Kopec J, Pey AL, Fitzpatrick F, Patel D, Chalk R, Streetha L, Yue WW
Hum. Mol. Genet.. 2016 . doi: 10.1093/hmg/ddw091
PMID: 27005423

Expanding the Genotypic Spectrum of Perrault syndrome.
Demain LA, Urquhart JE, O'Sullivan J, Williams SG, Bhaskar SS, Jenkinson EM, Lourenco CM, Heiberg A, Pearce SH, Shalev SA, Yue WW, Mackinnon S, Munro KJ, Newbury-Ecob R, Becker K, Kim MJ, O' Keefe RT, Newman WG
Clin. Genet.. 2016 . doi: 10.1111/cge.12776
PMID: 26970254

FORMATION OF NOVEL CITRULLINATED PEPTIDES BY PORPHYROMONASGINGIVALIS PAD ENZYME: IMPLICATIONS FOR AUTOIMMUNITY IN RHEUMATOID ARTHRITIS
Montgomery, AB; Kopec, J; Shrestha, L; Schewenzer, A; Correia, RE; Fischer, R; Burgess-Brown, N; Yue, WW; Venables, PJ;
Annals of the Rheumatic Diseases. 2016 75:A33-A33. doi: 10.1136/annrheumdis-2016-209124.80
PMID:

2015

Use of Methylmalonyl-CoA epimerase in Enhancing Crotonase Stereoselectivity.
Hamed RB, Gomez-Castellanos JR, Froese DS, Krysztofinska E, Yue WW, Schofield CJ
Chembiochem. 2015 . doi: 10.1002/cbic.201500644
PMID: 26716911

Role of reverse phenotyping in interpretation of next generation sequencing data and a review of INPP5E related disorders.
de Goede C, Yue WW, Yan G, Ariyaratnam S, Chandler KE, Downes L, Khan N, Mohan M, Lowe M, Banka S
Eur. J. Paediatr. Neurol.. 2015 . doi: 10.1016/j.ejpn.2015.11.012
PMID: 26748598

Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation.
Riemersma M, Froese DS, van Tol W, Engelke UF, Kopec J, van Scherpenzeel M, Ashikov A, Krojer T, von Delft F, Tessari M, Buczkowska A, Swiezewska E, Jae LT, Brummelkamp TR, Manya H, Endo T, van Bokhoven H, Yue WW, Lefeber DJ
Chem. Biol.. 2015 22(12):1643-52. doi: 10.1016/j.chembiol.2015.10.014
PMID: 26687144

Structural insights into the MMACHC-MMADHC protein complex involved in vitamin B12 trafficking.
Froese DS, Kopec J, Fitzpatrick F, Schuller M, McCorvie TJ, Chalk R, Plessl T, Fettelschoss V, Fowler B, Baumgartner MR, Yue WW
J. Biol. Chem.. 2015 . doi: 10.1074/jbc.M115.683268
PMID: 26483544

Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation.
Colak, G; Pougovkina, O; Dai, L; Tan, M; Te Brinke, H; Huang, H; Cheng, Z; Park, J; Wan, X; Liu, X; Yue, WW; Wanders, RJA; Locasale, JW; Lombard, DB; de Boer, VCJ; Zhao, Y;
Molecular and Cellular Proteomics. 2015 14:3056-3071. doi: 10.1074/mcp.M115.048850
PMID: 26320211

Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis.
Montgomery AB, Kopec J, Shrestha L, Thezenas ML, Burgess-Brown NA, Fischer R, Yue WW, Venables PJ
Ann. Rheum. Dis.. 2015 . doi: 10.1136/annrheumdis-2015-207656
PMID: 26209657

Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design.
Froese DS, Michaeli A, McCorvie TJ, Krojer T, Sasi M, Melaev E, Goldblum A, Zatsepin M, Lossos A, Álvarez R, Escribá PV, Minaissan BA, von Delft F, Kakhlon O, Yue WW
Hum. Mol. Genet.. 2015 . doi: 10.1093/hmg/ddv280
PMID: 26199317

Mutations in GMPPB cause congenital myasthenic syndrome and bridge myasthenic disorders with dystroglycanopathies.
Belaya K, Rodríguez Cruz PM, Liu WW, Maxwell S, McGowan S, Farrugia ME, Petty R, Walls TJ, Sedghi M, Basiri K, Yue WW, Sarkozy A, Bertoli M, Pitt M, Kennett R, Schaefer A, Bushby K, Parton M, Lochmüller H, Palace J, Muntoni F, Beeson D
Brain. 2015 . doi: 10.1093/brain/awv185
PMID: 26133662

Carnosine metabolism in diabetes is altered by reactive metabolites.
Peters, V; Lanthaler, B; Amberger, A; Fleming, T; Forsberg, E; Hecker, M; Wagner, AH; Yue, WW; Hoffmann, GF; Nawroth, P; Zschocke, J; Schmitt, CP;
Amino Acids. 2015 47:2367-2376. doi: 10.1007/s00726-015-2024-z
PMID: 26081982

2014

Inter-domain communication of human cystathionine β-synthase: structural basis of S-adenosyl-L-methionine activation.
McCorvie, TJ; Kopec, J; Hyung, S-J; Fitzpatrick, F; Feng, X; Termine, D; Strain-Damerell, C; Vollmar, M; Fleming, J; Janz, JM; Bulawa, C; Yue, WW;
Journal of Biological Chemistry. 2014 289:36018-36030. doi: 10.1074/jbc.M114.610782
PMID: 25336647

Expanding the clinical and molecular spectrum of thiamine pyrophosphokinase deficiency: A treatable neurological disorder caused by TPK1 mutations.
Banka S, de Goede C, Yue WW, Morris AA, von Bremen B, Chandler KE, Feichtinger RG, Hart C, Khan N, Lunzer V, Mataković L, Marquardt T, Makowski C, Prokisch H, Debus O, Nosaka K, Sonwalkar H, Zimmermann FA, Sperl W, Mayr JA
Mol. Genet. Metab.. 2014 . doi: 10.1016/j.ymgme.2014.09.010
PMID: 25458521

Linking genotypes database with locus-specific database and genotype-phenotype correlation in phenylketonuria.
Wettstein S, Underhaug J, Perez B, Marsden BD, Yue WW, Martinez A, Blau N
Eur. J. Hum. Genet.. 2014 . doi: 10.1038/ejhg.2014.114
PMID: 24939588

Enzymatic and Structural Characterization of rTSγ Provides Insights into the Function of rTSβ.
Wichelecki DJ, Froese DS, Kopec J, Muniz JR, Yue WW, Gerlt JA
Biochemistry. 2014 53(16):2732-8. doi: 10.1021/bi500349e
PMID: 24697329

Mutation or knock-down of 17β-hydroxysteroid dehydrogenase type 10 cause loss of MRPP1 and impaired processing of mitochondrial heavy strand transcripts.
Deutschmann AJ, Amberger A, Zavadil C, Steinbeisser H, Mayr JA, Feichtinger RG, Oerum S, Yue WW, Zschocke J
Hum. Mol. Genet.. 2014 . doi: 10.1093/hmg/ddu072
PMID: 24549042

Leri's pleonosteosis, a congenital rheumatic disease, results from microduplication at 8q22.1 encompassing GDF6 and SDC2 and provides insight into systemic sclerosis pathogenesis.
Banka S, Cain SA, Carim S, Daly SB, Urquhart JE, Erdem G, Harris J, Bottomley M, Donnai D, Kerr B, Kingston H, Superti-Furga A, Unger S, Ennis H, Worthington J, Herrick AL, Merry CL, Yue WW, Kielty CM, Newman WG
Ann. Rheum. Dis.. 2014 . doi: 10.1136/annrheumdis-2013-204309
PMID: 24442880

2013

5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation
Hopkinson, RJ; Tumber, A; Yapp, C; Chowdhury, R; Aik, WS; Che, KH; Li, XS; Kristensen, JBL; King, ONF; Chan, MC; Yeoh, KK; Choi, H; Walport, LJ; Thinnes, CC; Bush, JT; Lejeune, C; Rydzik, AM; Rose, NR; Bagg, EA; McDonough, MA; Krojer, TJ; Yue, WW; Ng, SS; Olsen, L; Brennan, PE; Oppermann, U; Müller, S; Klose, RJ; Ratcliffe, PJ; Schofield, CJ; Kawamura, A;
Chemical Science. 2013 4:3110-3117. doi: 10.1039/c3sc51122g
PMID: 26682036

Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations.
Froese DS, Forouhar F, Tran TH, Vollmar M, Kim YS, Lew S, Neely H, Seetharaman J, Shen Y, Xiao R, Acton TB, Everett JK, Cannone G, Puranik S, Savitsky P, Krojer T, Pilka ES, Kiyani W, Lee WH, Marsden BD, von Delft F, Allerston CK, Spagnolo L, Gileadi O, Montelione GT, Oppermann U, Yue WW, Tong L
Structure. 2013 . doi: 10.1016/j.str.2013.05.001
PMID: 23791943

Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits.
Shafqat, N; Muniz, JRC; Pilka, ES; Papagrigoriou, E; von Delft, F; Oppermann, U; Yue, WW;
Biochemical Journal. 2013 452:27-36. doi: 10.1042/BJ20121580
PMID: 23425511

A structural mapping of mutations causing succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency.
Shafqat N, Kavanagh KL, Sass JO, Christensen E, Fukao T, Lee WH, Oppermann U, Yue WW
J. Inherit. Metab. Dis.. 2013 . doi: 10.1007/s10545-013-9589-z
PMID: 23420214

LRIG2 Mutations Cause Urofacial Syndrome.
Stuart HM, Roberts NA, Burgu B, Daly SB, Urquhart JE, Bhaskar S, Dickerson JE, Mermerkaya M, Silay MS, Lewis MA, Olondriz MB, Gener B, Beetz C, Varga RE, Gülpınar O, Süer E, Soygür T, Ozçakar ZB, Yalçınkaya F, Kavaz A, Bulum B, Gücük A, Yue WW, Erdogan F, Berry A, Hanley NA, McKenzie EA, Hilton EN, Woolf AS, Newman WG
Am. J. Hum. Genet.. 2013 . doi: 10.1016/j.ajhg.2012.12.002
PMID: 23313374

2012

ENZYMATIC CHARACTERIZATION AND THERMAL STABILITY ASSAYS ESTABLISH METHYLMALONYL-COA MUTASE MUTATIONS AS A TARGET FOR PHARMACOLOGICAL CHAPERONE SCREENING
Forny, P; Froese, DS; Suormala, T; Yue, WW; Baumgartner, MR;
Journal of Inherited Metabolic Disease. 2012 35:S9-S9. doi:
PMID:

Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function.
Froese DS, Krojer T, Wu X, Shrestha R, Kiyani W, von Delft F, Gravel RA, Oppermann U, Yue WW
Biochemistry. 2012 51(25):5083-90. doi: 10.1021/bi300150y
PMID: 22642810

Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family.
Chaikuad A, Pilka ES, De Riso A, von Delft F, Kavanagh KL, Vénien-Bryan C, Oppermann U, Yue WW
BMC Struct. Biol.. 2012 12:14. doi: 10.1186/1472-6807-12-14
PMID: 22720794

3-methylcrotonyl-CoA carboxylase deficiency: clinical, biochemical, enzymatic and molecular studies in 88 individuals.
Grünert SC, Stucki M, Morscher RJ, Suormala T, Bürer C, Burda P, Christensen E, Ficicioglu C, Herwig J, Kölker S, Möslinger D, Pasquini E, Santer R, Schwab KO, Wilcken B, Fowler B, Yue WW, Baumgartner MR
Orphanet J Rare Dis. 2012 7:31. doi: 10.1186/1750-1172-7-31
PMID: 22642865

2011

Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.
Chaikuad A, Froese DS, Berridge G, von Delft F, Oppermann U, Yue WW
Proc. Natl. Acad. Sci. U.S.A.. 2011 108(52):21028-33. doi: 10.1073/pnas.1113921108
PMID: 22160680

Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.
Hillringhaus L, Yue WW, Rose NR, Ng SS, Gileadi C, Loenarz C, Bello SH, Bray JE, Schofield CJ, Oppermann U
J. Biol. Chem.. 2011 286(48):41616-25. doi: 10.1074/jbc.M111.283689
PMID: 21914792

Interactive JIMD articles using the iSee concept: turning a new page on structural biology data
Lee, WH; Yue, WW; Raush, E; Totrov, M; Abagyan, R; Oppermann, U; Marsden, BD;
Journal of Inherited Metabolic Disease. 2011 :1-3. doi: 10.1007/s10545-011-9334-4
PMID: 21509537

Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDS.
Chaikuad A, Shafqat N, Al-Mokhtar R, Cameron G, Clarke AR, Brady RL, Oppermann U, Frayne J, Yue WW
Biochem. J.. 2011 435(2):401-9. doi: 10.1042/BJ20101442
PMID: 21269272

Structural basis of fumarate hydratase deficiency.
Picaud S, Kavanagh KL, Yue WW, Lee WH, Muller-Knapp S, Gileadi O, Sacchettini J, Oppermann U
J. Inherit. Metab. Dis.. 2011 34(3):671-6. doi: 10.1007/s10545-011-9294-8
PMID: 21445611

INTERACTIVE 3D VISUALISATIONS OF PROTEIN STRUCTURES TO AID THE STUDY OF INBORN ERRORS OF METABOLISM
Lee, WH; Raush, E; Totrov, M; Abagyan, R; Marsden, BD; Oppermann, U; Yue, WW;
Journal of Inherited Metabolic Disease. 2011 34:S240-S240. doi:
PMID:

DELINEATING THE MITOCHONDRIAL VITAMIN B12 PATHWAY THROUGH STRUCTURAL AND INTERACTION STUDIES
Froese, DS; Kochan, G; Muniz, JRC; Chaikuad, A; Wu, X; Gileadi, C; Ugochukwu, E; Krysztofinska, E; Gravel, RA; Oppermann, U; Yue, WW;
Journal of Inherited Metabolic Disease. 2011 34:S119-S119. doi:
PMID:

2010

Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation.
Froese DS, Kochan G, Muniz JR, Wu X, Gileadi C, Ugochukwu E, Krysztofinska E, Gravel RA, Oppermann U, Yue WW
J. Biol. Chem.. 2010 285(49):38204-13. doi: 10.1074/jbc.M110.177717
PMID: 20876572

Structural impact of human and Escherichia coli biotin carboxyl carrier proteins on biotin attachment.
Healy S, McDonald MK, Wu X, Yue WW, Kochan G, Oppermann U, Gravel RA
Biochemistry. 2010 49(22):4687-94. doi: 10.1021/bi901612y
PMID: 20443544

Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase.
Yue WW, Hozjan V, Ge W, Loenarz C, Cooper CD, Schofield CJ, Kavanagh KL, Oppermann U, McDonough MA
FEBS Lett.. 2010 584(4):825-30. doi: 10.1016/j.febslet.2009.12.055
PMID: 20067792

2009

Crystal structure of human carbonic anhydrase-related protein VIII reveals the basis for catalytic silencing.
Picaud SS, Muniz JR, Kramm A, Pilka ES, Kochan G, Oppermann U, Yue WW
Proteins. 2009 76(2):507-11. doi: 10.1002/prot.22411
PMID: 19360879

Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A.
Kochan G, Pilka ES, von Delft F, Oppermann U, Yue WW
J. Mol. Biol.. 2009 388(5):997-1008. doi: 10.1016/j.jmb.2009.03.064
PMID: 19345228

Dynamic protein methylation in chromatin biology.
Ng, SS; Yue, WW; Oppermann, U; Klose, RJ;
Cellular and Molecular Life Sciences. 2009 66:407-422. doi: 10.1007/s00018-008-8303-z
PMID: 18923809

2007

Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture.
Hassler, M; Singh, S; Yue, WW; Luczynski, M; Lakbir, R; Sanchez-Sanchez, F; Bader, T; Pearl, LH; Mittnacht, S;
Molecular Cell. 2007 28:371-385. doi: 10.1016/j.molcel.2007.08.023
PMID: 17996702

Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase.
Yue, WW; Hassler, M; Roe, SM; Thompson-Vale, V; Pearl, LH;
EMBO Journal. 2007 26:4402-4412. doi: 10.1038/sj.emboj.7601856
PMID: 17882261

2004

Recognition of iron-free siderophores by TonB-dependent iron transporters.
Schalk, IJ; Yue, WW; Buchanan, SK;
Molecular Microbiology. 2004 54:14-22. doi: 10.1111/j.1365-2958.2004.04241.x
PMID: 15458401

2003

Structural evidence for iron-free citrate and ferric citrate binding to the TonB-dependent outer membrane transporter FecA.
Yue, WW; Grizot, S; Buchanan, SK;
Journal of Molecular Biology. 2003 332:353-368. doi:
PMID: 12948487

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