Pubmed idTitleAuthorsVolume:PagesJournalDOIPublication Date
33438817Large-scale survey and database of high affinity ligands for peptide recognition modules.Teyra J, Kelil A, Jain S, Helmy M, Jajodia R, Hooda Y, Gu J, D'Cruz AA, Nicholson SE, Min J, Sudol M, Kim PM, Bader GD, Sidhu SS16(12):e9310Mol Syst Biol10.15252/msb.2019931014.01.2021
33398170Molecular basis for ubiquitin ligase CRL2FEM1C-mediated recognition of C-degron.Yan X, Wang X, Li Y, Zhou M, Li Y, Song L, Mi W, Min J, Dong CNat Chem Biol10.1038/s41589-020-00703-404.01.2021
33313896Identification of lysine isobutyrylation as a new histone modification mark.Zhu Z, Han Z, Halabelian L, Yang X, Ding J, Zhang N, Ngo L, Song J, Zeng H, He M, Zhao Y, Arrowsmith CH, Luo M, Bartlett MG, Zheng YGNucleic Acids Res10.1093/nar/gkaa117611.12.2020
33046718Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regionsSieberts SK, Perumal TM, Carrasquillo MM, Allen M, Reddy JS, Hoffman GE, Dang KK, Calley J, Ebert PJ, Eddy J, Wang X, Greenwood AK, Mostafavi S, Akbarian S, Bendl J, Breen MS, Brennand K, Brown L, Browne A, Buxbaum JD, Charney A, Chess A, Couto L, Crawford G, Devillers O, Devlin B, Dobbyn A, Domenici E, Filosi M, Flatow E, Francoeur N, Fullard J, Gil SE, Girdhar K, Gulyás-Kovács A, Gur R, Hahn CG, Haroutunian V, Hauberg ME, Huckins L, Jacobov R, Jiang Y, Johnson JS, Kassim B, Kim Y, Klei L, Kramer R, Lauria M, Lehner T, Lewis DA, Lipska BK, Montgomery K, Park R, Rosenbluh C, Roussos P, Ruderfer DM, Senthil G, Shah HR, Sloofman L, Song L, Stahl E, Sullivan P, Visintainer R, Wang J, Wang YC, Wiseman J, Xia E, Zhang W, Zharovsky E, Addis L, Addo SN, Airey DC, Arnold M, Bennett DA, Bi Y, Biber K, Blach C, Bradhsaw E, Brennan P, Canet-Aviles R, Cao S, Cavalla A, Chae Y, Chen WW, Cheng J, Collier DA, Dage JL, Dammer EB, Davis JW, Davis J, Drake D, Duong D, Eastwood BJ, Ehrlich M, Ellingson B, Engelmann BW, Esmaeelinieh S, Felsky D, Funk C, Gaiteri C7:-Scientific Data10.1038/s41597-020-00642-801.12.2020
Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixturesBaker LM, Aimon A, Murray JB, Surgenor AE, Matassova N, Roughley SD, Collins PM, Krojer T, von Delft F, Hubbard RE3:-Communications Chemistry10.1038/s42004-020-00367-001.12.2020
33214684Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivityPinto-Fernandez A, SALIO M, PARTRIDGE T, Chen J, Vere G, Greenwood H, Olie CS, DAMIANOU A, SCOTT HC, Pegg J, Chiarenza A, Diaz-Saez L, SMITH P, GONZALEZ-LOPEZ C, Patel B, Jones N, Hammonds T, HUBER K, MUSCHEL R, BORROW P, CERUNDOLO V, KESSLER BBritish Journal of Cancer10.1038/s41416-020-01167-y20.11.2020
33215738Decreased blood vessel density and endothelial cell subset dynamics during ageing of the endocrine systemChen J, Lippo L, Labella R, Tan SL, Marsden BD, Dustin ML, Ramasamy SK, Kusumbe AP:e105242-EMBO Journal10.15252/embj.202010524220.11.2020
33090784Epigenetics 2.0: Special Issue on Epigenetics-Call for Papers.Conway SJ, Arimondo P, Arrowsmith C, Jin J, Luo C, Meanwell N, Young W, Georg G, Wang S63(21):12129-12130J Med Chem10.1021/acs.jmedchem.0c0174812.11.2020
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashionKidd SL, Fowler E, Reinhardt T, Compton T, Mateu N, Newman H, Bellini D, Talon R, McLoughlin J, Krojer T, Aimon A, Bradley A, Fairhead M, Brear P, Díaz-Sáez L, McAuley K, Sore HF, Madin A, O'Donovan DH, Huber KVM, Hyvönen M, Von Delft F, Dowson CG, Spring DR11:10792-10801Chemical Science10.1039/d0sc01232g20.10.2020
33036015A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models.Mielnik CA, Sugamori KS, Finlay DB, Thorpe HHA, Schapira M, Sivananthan N, Li CK, Lam VM, Harrington S, Abdelrahman MH, Trembleau LA, McIntyre Burnham W, Khokhar JY, Salahpour A, Ramsey AJ, Glass M, Greig IR, Ross RANeuropsychopharmacology10.1038/s41386-020-00876-508.10.2020
33028632Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.Vilema-Enríquez G, Quinlan R, Kilfeather P, Mazzone R, Saqlain S, Del Molino Del Barrio I, Donato A, Corda G, Li F, Vedadi M, Németh AH, Brennan PE, Wade-Martins RJ Biol Chem10.1074/jbc.RA120.01553307.10.2020
33028810Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main proteaseDouangamath A, Fearon D, Gehrtz P, Krojer T, Lukacik P, Owen CD, Resnick E, Strain-Damerell C, Aimon A, Ábrányi-Balogh P, Brandão-Neto J, Carbery A, Davison G, Dias A, Downes TD, Dunnett L, Fairhead M, Firth JD, Jones SP, Keeley A, Keserü GM, Klein HF, Martin MP, Noble MEM, O’Brien P, Powell A, Reddi RN, Skyner R, Snee M, Waring MJ, Wild C, London N, von Delft F, Walsh MA11:5047-Nature Communications10.1038/s41467-020-18709-w06.10.2020
33094717SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020Lumley SF, Eyre DW, McNaughton AL, Howarth A, Hoosdally S, Hatch SB, Kavanagh J, Chau KK, Downs LO, Cox S, Dunn L, Justice A, Wareing S, Dingle K, Rudkin J, Auckland K, Fyfe A, Bolton J, Paton R, Mentzer AJ, Jeffery K, Andersson MI, James T, Peto TEA, Marsden BD, Screaton G, Cornall RJ, Klenerman P, Ebner D, Stuart DI, Crook DW, Stoesser N, Kennedy SH, Thompson C, Gupta S, Matthews PC25:-Eurosurveillance10.2807/1560-7917.es.2020.25.41.200172130.09.2020
32979318Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparisonAinsworth M, Andersson M, Auckland K, Baillie JK, Barnes E, Beer S, Beveridge A, Bibi S, Blackwell L, Borak M, Bown A, Brooks T, Burgess-Brown NA, Camara S, Catton M, Chau KK, Christott T, Clutterbuck E, Coker J, Cornall RJ, Cox S, Crawford-Jones D, Crook DW, D'Arcangelo S, Dejnirattsai W, Dequaire JMM, Dimitriadis S, Dingle KE, Doherty G, Dold C, Dong T, Dunachie SJ, Ebner D, Emmenegger M, Espinosa A, Eyre DW, Fairhead R, Fassih S, Feehily C, Felle S, Fernandez-Cid A, Fernandez Mendoza M, Foord TH, Fordwoh T, Fox McKee D, Frater J, Gallardo Sanchez V, Gent N, Georgiou D, Groves CJ, Hallis B, Hammond PM, Hatch SB, Harvala HJ, Hill J, Hoosdally SJ, Horsington B, Howarth A, James T, Jeffery K, Jones E, Justice A, Karpe F, Kavanagh J, Kim DS, Kirton R, Klenerman P, Knight JC, Koukouflis L, Kwok A, Leuschner U, Levin R, Linder A, Lockett T, Lumley SF, Marinou S, Marsden BD, Martinez J, Martins Ferreira L, Mason L, Matthews PC, Mentzer AJ, Mobbs A, Mongkolsapaya J, Morrow J, Mukhopadhyay SMM, Neville MJ, Oakley S, Oliveira M, Otter A, Paddon K, Pascoe J, Peng Y, Perez E, Perumal PK, Peto TEA, Pickford H, Ploeg RJ, Pollard AJ, Richardson A, Ritter TG, Roberts DJ, Rodger G, Rollier CS, Rowe C, Rudkin JK, Screaton G, Semple MG, Sienkiewicz A, Silva-Reyes L, Skelly DT, Sobrino Diaz A, Stafford L, Stockdale L, Stoesser N, Street T, Stuart DI, Sweed A, Taylor A, Thraves H, Tsang HP, Verheul MK, Vipond R, Walker TM, Wareing S, Warren Y, Wells C, Wilson C, Withycombe K, Young RKThe Lancet Infectious Diseases10.1016/s1473-3099(20)30634-422.09.2020
32939018Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate.Schuhmacher MK, Beldar S, Khella MS, Bröhm A, Ludwig J, Tempel W, Weirich S, Min J, Jeltsch A3(1):511Commun Biol10.1038/s42003-020-01223-616.09.2020
32917713LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium.Zwiggelaar RT, Lindholm HT, Fosslie M, Terndrup Pedersen M, Ohta Y, Díez-Sánchez A, Martín-Alonso M, Ostrop J, Matano M, Parmar N, Kvaløy E, Spanjers RR, Nazmi K, Rye M, Drabløs F, Arrowsmith C, Arne Dahl J, Jensen KB, Sato T, Oudhoff MJ6(37):Sci Adv10.1126/sciadv.abc036713.09.2020
32914973What Are the Odds of Finding a COVID-19 Drug from a Lab Repurposing Screen?Edwards AJ Chem Inf Model10.1021/acs.jcim.0c0086111.09.2020
32881878Ten simple rules for open human health research.Bafeta A, Bobe J, Clucas J, Gonsalves PP, Gruson-Daniel C, Hudson KL, Klein A, Krishnakumar A, McCollister-Slipp A, Lindner AB, Misevic D, Naslund JA, Nebeker C, Nikolaidis A, Pasquetto I, Sanchez G, Schapira M, Scheininger T, Schoeller F, Sólon Heinsfeld A, Taddei F16(9):e1007846PLoS Comput. Biol.10.1371/journal.pcbi.100784604.09.2020
32869745Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19.Dong C, Nakagawa R, Oyama K, Yamamoto Y, Zhang W, Dong A, Li Y, Yoshimura Y, Kamiya H, Nakayama JI, Ueda J, Min J9:Elife10.7554/eLife.5867501.09.2020
32877430TargetDB: A target information aggregation tool and tractability predictorDe Cesco S, Davis JB, Brennan PE15:e0232644-e0232644PLOS ONE10.1371/journal.pone.023264401.09.2020
32855205Inhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell DeathCottone L, Cribbs AP, Khandelwal G, Wells G, Ligammari L, Philpott M, Tumber A, Lombard P, Hookway ES, Szommer T, Johansson C, Brennan PE, Pillay N, Jenner RG, Oppermann U, Flanagan AM80:4540-4551Cancer Research10.1158/0008-5472.can-20-138726.08.2020
32826891GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer.Wu Q, Ba-Alawi W, Deblois G, Cruickshank J, Duan S, Lima-Fernandes E, Haight J, Tonekaboni SAM, Fortier AM, Kuasne H, McKee TD, Mahmoud H, Kushida M, Cameron S, Dogan-Artun N, Chen W, Nie Y, Zhang LX, Vellanki RN, Zhou S, Prinos P, Wouters BG, Dirks PB, Done SJ, Park M, Cescon DW, Haibe-Kains B, Lupien M, Arrowsmith CH11(1):4205Nat Commun10.1038/s41467-020-18020-821.08.2020
32820721Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational studyEyre DW, Lumley SF, O'Donnell D, Campbell M, Sims E, Lawson E, Warren F, James T, Cox S, Howarth A, Doherty G, Hatch SB, Kavanagh J, Chau KK, Fowler PW, Swann J, Volk D, Yang-Turner F, Stoesser N, Matthews PC, Dudareva M, Davies T, Shaw RH, Peto L, Downs LO, Vogt A, Amini A, Young BC, Drennan PG, Mentzer AJ, Skelly DT, Karpe F, Neville MJ, Andersson M, Brent AJ, Jones N, Martins Ferreira L, Christott T, Marsden BD, Hoosdally S, Cornall R, Crook DW, Stuart DI, Screaton G, Watson AJR, Taylor A, Chetwynd A, Grassam-Rowe A, Mighiu AS, Livingstone A, Killen A, Rigler C, Harries C, East C, Lee C, Mason CJB, Holland C, Thompson C, Hennesey C, Savva C, Kim DS, Harris EWA, McGivern EJ, Qian E, Rothwell E, Back F, Kelly G, Watson G, Howgego G, Chase H, Danbury H, Laurenson-Schafer H, Ward HL, Hendron H, Vorley IC, Tol I, Gunnell J, Ward JLF, Drake J, Wilson JD, Morton J, Dequaire J, O'Byrne K, Motohashi K, Harper K, Ravi K, Millar LJ, Peck LJ, Oliver M, English MR, Kumarendran M, Wedlich M, Ambler O, Deal OT, Sweeney O, Cowie P, Naudé RTW, Young R, Freer R, Scott S, Sussmes S, Peters S, Pattenden S, Waite S, Johnson SA, Kourdov S, Santos-Paulo S, Dimitrov S, Kerneis S, Ahmed-Firani T, King TB, Ritter TG, Foord TH, De Toledo Z, Christie T, Gergely B, Axten D, Simons E-J, Nevard H, Philips J, Szczurkowska J, Patel K, Smit K, Warren L, Morgan L, Smith L, Robles M, McKnight M, Luciw M, Gates M, Sande N, Turford R, Ray R, Rughani S, Mitchell T, Bellinger T, Wharton V, Justice A, Jesuthasan G, Wareing S, Huda Mohamad Fadzillah N, Cann K, Kirton R, Sutton C, Salvagno C, DAmato G, Pill G, Butcher L, Rylance-Knight L, Tabirao M, Moroney R, Wright S, Peto TEA, Holthof B, O'Donnell A-M, Ebner D, Conlon CP, Jeffery K, Walker TM9:1-37eLife10.7554/elife.6067520.08.2020
32812371Deliberately Losing Control of C−H Activation Processes in the Design of Small-Molecule-Fragment Arrays Targeting Peroxisomal MetabolismKhan Tareque R, Hassell-Hart S, Krojer T, Bradley A, Velupillai S, Talon R, Fairhead M, Day IJ, Bala K, Felix R, Kemmitt PD, Brennan P, von Delft F, Díaz Sáez L, Huber K, Spencer JChemMedChem10.1002/cmdc.20200054317.08.2020
32787076DFG-1 Residue Controls Inhibitor Binding Mode and Affinity, Providing a Basis for Rational Design of Kinase Inhibitor SelectivitySchröder M, Bullock AN, Fedorov O, Bracher F, Chaikuad A, Knapp S63:10224-10234Journal of Medicinal Chemistry10.1021/acs.jmedchem.0c0089811.08.2020
32787083Leveraging an Open Science Drug Discovery Model to Develop CNS Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma.Smil D, Wong JF, Williams E, Adamson R, Howarth A, McLeod D, Mamai A, Kim S, Wilson B, Kiyota T, Aman A, Owen J, Poda G, Horiuchi K, Kuznetsova E, Ma H, Hamblin JN, Cramp S, Roberts O, Edwards AM, Uehling D, Al-Awar R, Bullock AN, O'Meara J, Isaac MJ. Med. Chem.10.1021/acs.jmedchem.0c0119911.08.2020
32766792LOTUS domain is a novel class of G-rich and G-quadruplex RNA binding domain.Ding D, Wei C, Dong K, Liu J, Stanton A, Xu C, Min J, Hu J, Chen CNucleic Acids Res.10.1093/nar/gkaa65207.08.2020
32701288Dataset Augmentation Allows Deep Learning-Based Virtual Screening To Better Generalize To Unseen Target Classes, And Highlight Important Binding Interactions.Scantlebury J, Brown N, von Delft F, Deane CM60:3722-3730Journal of chemical information and modeling10.1021/acs.jcim.0c0026322.07.2020
32689795Selective Peptidomimetic Inhibitors of NTMT1/2: Rational design, synthesis, characterization, and crystallographic studies.Mackie BD, Chen D, Dong G, Dong C, Parker H, Tooley C, Noinaj N, Min J, Huang RJ. Med. Chem.10.1021/acs.jmedchem.0c0068920.07.2020
32609811Alternative splicing and allosteric regulation modulate the chromatin binding of UHRF1.Tauber M, Kreuz S, Lemak A, Mandal P, Yerkesh Z, Veluchamy A, Al-Gashgari B, Aljahani A, Cortés-Medina LV, Azhibek D, Fan L, Ong MS, Duan S, Houliston S, Arrowsmith CH, Fischle WNucleic Acids Res.10.1093/nar/gkaa52001.07.2020
32605369Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogs.Chen D, Dong C, Dong G, Srinivasan K, Min J, Noinaj N, Huang RJ. Med. Chem.10.1021/acs.jmedchem.0c0077001.07.2020
32555379Crowdsourcing drug discovery for pandemicsChodera J, Lee AA, London N, von Delft F12:581-Nature Chemistry10.1038/s41557-020-0496-230.06.2020
32467316STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancersvan der Lelij P, Newman JA, Lieb S, Jude J, Katis V, Hoffmann T, Hinterndorfer M, Bader G, Kraut N, Pearson MA, Peters JM, Zuber J, Gileadi O, Petronczki M3:-Life science alliance10.26508/lsa.20200072530.06.2020
Hepatitis B virus resistance to tenofovir: fact or fiction? A systematic literature review and structural analysis of drug resistance mechanismsMokaya J, McNaughton AL, Bester PA, Goedhals D, Barnes E, Marsden BD, Matthews PC5:151-151Wellcome Open Research10.12688/wellcomeopenres.15992.128.06.2020
32605268Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-7.Gütschow M, Eynde JJV, Jampilek J, Kang C, Mangoni AA, Fossa P, Karaman R, Trabocchi A, Scott PJH, Reynisson J, Rapposelli S, Galdiero S, Winum JY, Brullo C, Prokai-Tatrai K, Sharma AK, Schapira M, Azuma YT, Cerchia L, Spetea M, Torri G, Collina S, Geronikaki A, García-Sosa AT, Vasconcelos MH, Sousa ME, Kosalec I, Tuccinardi T, Duarte IF, Salvador JAR, Bertinaria M, Pellecchia M, Amato J, Rastelli G, Gomes PAC, Guedes RC, Sabatier JM, Estévez-Braun A, Pagano B, Mangani S, Ragno R, Kokotos G, Brindisi M, González FV, Borges F, Miloso M, Rautio J, Muñoz-Torrero D25(13):Molecules10.3390/molecules2513296828.06.2020
32574548Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12Chen Z, Wasney GA, Picaud S, Filippakopoulos P, Vedadi M, D'Angiolella V, Bullock AN10(6):200041Open Biol10.1098/rsob.20004124.06.2020
32574548Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12.Chen Z, Wasney GA, Picaud S, Filippakopoulos P, Vedadi M, D'Angiolella V, Bullock AN10(6):200041Open Biol10.1098/rsob.20004124.06.2020
32546577Epigenetic switch-induced viral mimicry evasion in chemotherapy resistant breast cancer.Deblois G, Madani Tonekaboni SA, Grillo G, Martinez C, Kao YI, Tai F, Ettayebi I, Fortier AM, Savage P, Fedor AN, Liu X, Guilhamon P, Lima-Fernandes E, Murison A, Kuasne H, Ba-Alawi W, Cescon DW, Arrowsmith CH, De Carvalho DD, Haibe-Kains B, Locasale JW, Park M, Lupien MCancer Discov10.1158/2159-8290.CD-19-149316.06.2020
32531202Tuning transcription factor availability through acetylation-mediated genomic redistributionGODING C79:472-487.e10Molecular Cell10.1016/j.molcel.2020.05.02510.06.2020
32513738Recognition of nonproline N-terminal residues by the Pro/N-degron pathway.Dong C, Chen SJ, Melnykov A, Weirich S, Sun K, Jeltsch A, Varshavsky A, Min JProc. Natl. Acad. Sci. U.S.A.10.1073/pnas.200708511708.06.2020
32499479Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop regulating substrate binding and product releaseBailey HJ, Bezerra GA, Marcero JR, Padhi S, Foster WR, Rembeza E, Roy A, Bishop DF, Desnick RJ, Bulusu G, Dailey HA, Yue WW11:2813-Nature Communications10.1038/s41467-020-16586-x03.06.2020
32488087Quantifying CDK inhibitor selectivity in live cellsWells CI, Vasta JD, Corona CR, Wilkinson J, Zimprich CA, Ingold MR, Pickett JE, Drewry DH, Pugh KM, Schwinn MK, Hwang B, Zegzouti H, Huber KVM, Cong M, Meisenheimer PL, Willson TM, Robers MB11:2743-Nature Communications10.1038/s41467-020-16559-001.06.2020
32590358Preclinical drug studies in MEN1-related neuroendocrine neoplasms (MEN1-NENs)Grozinsky-Glasberg S, Lines KE, Avniel-Polak S, Bountra C, Thakker RV27:R345-R355Endocrine-related cancer10.1530/ERC-20-012731.05.2020
32470319Structural Basis for the Binding Selectivity of Human CDY Chromodomains.Dong C, Liu Y, Lyu TJ, Beldar S, Lamb KN, Tempel W, Li Y, Li Z, James LI, Qin S, Wang Y, Min JCell Chem Biol10.1016/j.chembiol.2020.05.00726.05.2020
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main proteaseKROJER T, Douangamath A, Fearon D, Gehrtz P, Lukacik P, Owen CD, Resnick E, Strain-Damerell C, Aimon A, Ábrányi-Balogh P, Brandaõ-Neto J, Carbery A, Davison G, Dias A, Downes TD, Dunnett L, FAIRHEAD M, Firth JD, Jones P, Keely A, Keserü GM, Klein HF, Martin MP, Noble MEM, O’Brien P, Powell A, Reddi R, Skyner R, Snee M, Waring MJ, Wild C, London N, VON DELFT F, Walsh MEbiorxiv10.1101/2020.05.27.11811726.05.2020
32445698Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.Michealraj KA, Kumar SA, Kim LJY, Cavalli FMG, Przelicki D, Wojcik JB, Delaidelli A, Bajic A, Saulnier O, MacLeod G, Vellanki RN, Vladoiu MC, Guilhamon P, Ong W, Lee JJY, Jiang Y, Holgado BL, Rasnitsyn A, Malik AA, Tsai R, Richman CM, Juraschka K, Haapasalo J, Wang EY, De Antonellis P, Suzuki H, Farooq H, Balin P, Kharas K, Van Ommeren R, Sirbu O, Rastan A, Krumholtz SL, Ly M, Ahmadi M, Deblois G, Srikanthan D, Luu B, Loukides J, Wu X, Garzia L, Ramaswamy V, Kanshin E, Sánchez-Osuna M, El-Hamamy I, Coutinho FJ, Prinos P, Singh S, Donovan LK, Daniels C, Schramek D, Tyers M, Weiss S, Stein LD, Lupien M, Wouters BG, Garcia BA, Arrowsmith CH, Sorensen PH, Angers S, Jabado N, Dirks PB, Mack SC, Agnihotri S, Rich JN, Taylor MDCell10.1016/j.cell.2020.04.04720.05.2020
32505849Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffoldSuebsuwong C, Dai B, Pinkas DM, Duddupudi AL, Li L, Bufton JC, Schlicher L, Gyrd-Hansen M, Hu M, Bullock AN, Degterev A, Cuny GD200:112417-European Journal of Medicinal Chemistry10.1016/j.ejmech.2020.11241714.05.2020
32409666Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response.Szewczyk MM, Ishikawa Y, Organ S, Sakai N, Li F, Halabelian L, Ackloo S, Couzens AL, Eram M, Dilworth D, Fukushi H, Harding R, Dela Seña CC, Sugo T, Hayashi K, McLeod D, Zepeda C, Aman A, Sánchez-Osuna M, Bonneil E, Takagi S, Al-Awar R, Tyers M, Richard S, Takizawa M, Gingras AC, Arrowsmith CH, Vedadi M, Brown PJ, Nara H, Barsyte-Lovejoy D11(1):2396Nat Commun10.1038/s41467-020-16271-z14.05.2020
32369358Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma.Ensan D, Smil D, Zepeda-Velázquez CA, Panagopoulos D, Wong JF, Williams EP, Adamson R, Bullock AN, Kiyota T, Aman A, Roberts OG, Edwards AM, O'Meara JA, Isaac MB, Al-Awar RJ. Med. Chem.10.1021/acs.jmedchem.0c0039505.05.2020
32367723Discovery of a First-in-class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor.Shen Y, Li F, Szewczyk MM, Halabelian L, Park KS, Chau I, Dong A, Zeng H, Chen H, Meng F, Barsyte-Lovejoy D, Arrowsmith CH, Brown P, Liu J, Vedadi M, Jin JJ. Med. Chem.10.1021/acs.jmedchem.0c0040605.05.2020
32499642A lower X-gate in TASK channels traps inhibitors within the vestibuleRODSTROM K, Kiper A, Zhang W, Rinne S, PIKE A, Goldstein M, Conrad L, Delbeck M, Hahn M, Meier H, Platzk M, Quigley A, Speedman D, SHRESTHA L, Mukhopadhyay S, BURGESS-BROWN N, TUCKER S, Mueller T, Decher N, CARPENTER E582:443-447Nature10.1038/s41586-020-2250-828.04.2020
32297856Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment.Criqui M, Qamra A, Chu TW, Sharma M, Tsao J, Henry DA, Barsyte-Lovejoy D, Arrowsmith CH, Winegarden N, Lupien M, Harrington L9:Elife10.7554/eLife.4733316.04.2020
Targeting der kleinen GTPasen über ihre regulatorischen ProteineGray JL, Delft F, Brennan PE132:6402-6428Angewandte Chemie10.1002/ange.20190058515.04.2020
32085971Development of 2-(4-pyridyl)-benzimidazoles as PKN2 chemical tools to probe cancerScott F, Fala AM, Pennicott LE, Reuillon TD, Massirer KB, Elkins JM, Ward SE30:127040-Bioorganic and Medicinal Chemistry Letters10.1016/j.bmcl.2020.12704014.04.2020
32265506The RESOLUTE consortium: unlocking SLC transporters for drug discovery.Superti-Furga G, Lackner D, Wiedmer T, Ingles-Prieto A, Barbosa B, Girardi E, Goldmann U, Gürtl B, Klavins K, Klimek C, Lindinger S, Liñeiro-Retes E, Müller AC, Onstein S, Redinger G, Reil D, Sedlyarov V, Wolf G, Crawford M, Everley R, Hepworth D, Liu S, Noell S, Piotrowski M, Stanton R, Zhang H, Corallino S, Faedo A, Insidioso M, Maresca G, Redaelli L, Sassone F, Scarabottolo L, Stucchi M, Tarroni P, Tremolada S, Batoulis H, Becker A, Bender E, Chang YN, Ehrmann A, Müller-Fahrnow A, Pütter V, Zindel D, Hamilton B, Lenter M, Santacruz D, Viollet C, Whitehurst C, Johnsson K, Leippe P, Baumgarten B, Chang L, Ibig Y, Pfeifer M, Reinhardt J, Schönbett J, Selzer P, Seuwen K, Bettembourg C, Biton B, Czech J, de Foucauld H, Didier M, Licher T, Mikol V, Pommereau A, Puech F, Yaligara V, Edwards A, Bongers BJ, Heitman LH, IJzerman AP, Sijben HJ, van Westen GJP, Grixti J, Kell DB, Mughal F, Swainston N, Wright-Muelas M, Bohstedt T, Burgess-Brown N, Carpenter L, Dürr K, Hansen J, Scacioc A, Banci G, Colas C, Digles D, Ecker G, Füzi B, Gamsjäger V, Grandits M, Martini R, Troger F, Altermatt P, Doucerain C, Dürrenberger F, Manolova V, Steck AL, Sundström H, Wilhelm M, Steppan CMNat Rev Drug Discov10.1038/d41573-020-00056-607.04.2020
32207937Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug DesignCurran PR, Radoux CJ, Smilova MD, Sykes RA, Higueruelo AP, Bradley AR, Marsden BD, Spring DR, Blundell TL, Leach AR, Pitt WR, Cole JC60:1911-1916Journal of chemical information and modeling10.1021/acs.jcim.9b0099601.04.2020
32209463Structural Basis for EPC1-Mediated Recruitment of MBTD1 into the NuA4/TIP60 Acetyltransferase Complex.Zhang H, Devoucoux M, Song X, Li L, Ayaz G, Cheng H, Tempel W, Dong C, Loppnau P, Côté J, Min J30(12):3996-4002.e4Cell Rep10.1016/j.celrep.2020.03.00324.03.2020
32208767Quantifying Target Occupancy of Small Molecules within Living CellsRobers MB, Friedman-Ohana R, Huber KVM, Huber KVM, Kilpatrick L, Kilpatrick L, Vasta JD, Berger BT, Chaudhry C, Hill S, Hill S, Müller S, Müller S, Knapp S, Knapp S, Knapp S, Knapp S, Wood KV, Wood KV89:557-581Annual Review of Biochemistry10.1146/annurev-biochem-011420-09230224.03.2020
32176847A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5Hanke T, Wong JF, Berger B-T, Abdi I, Berger LM, Tesch R, Tredup C, Bullock AN, Müller S, Knapp S15:862-870ACS Chemical Biology10.1021/acschembio.0c0007620.03.2020
32292539Importance of Quantifying Drug-Target Engagement in CellsStefaniak J, Huber KVM11:403-406ACS Medicinal Chemistry Letters10.1021/acsmedchemlett.9b0057006.03.2020
32142668Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric GliomasFortin J, Tian R, Zarrabi I, Hill G, Williams E, Sanchez-Duffhues G, Thorikay M, Ramachandran P, Siddaway R, Wong JF, Wu A, Apuzzo LN, Haight J, You-Ten A, Snow BE, Wakeham A, Goldhamer DJ, Schramek D, Bullock AN, Dijke PT, Hawkins C, Mak TW37:308-323.e12Cancer Cell10.1016/j.ccell.2020.02.00205.03.2020
31701538Crystal structure of the catalytic D2 domain of the AAA+ ATPase p97 reveals a putative helical split-washer-type mechanism for substrate unfoldingStach L, Morgan RM, Makhlouf L, Douangamath A, von Delft F, Zhang X, Freemont PS594:933-943FEBS Letters10.1002/1873-3468.1366701.03.2020
31935194Effects of epigenetic pathway inhibitors on corticotroph tumour AtT20 cellsLINES K, FILIPPAKOPOULOS P, STEVENSON M, Lockstone H, WRIGHT B, BUCK D, BOUNTRA C, THAKKER RV27:163-174Endocrine-Related Cancer10.1530/ERC-19-044801.03.2020
Re-evaluating the mechanism of action of α,β-unsaturated carbonyl DUB inhibitors b-AP15 and VLX1570: a paradigmatic example of unspecific protein crosslinking with Michael acceptor motif-containing drugsWARD JA, PINTO FERNANDEZ A, Cornelissen L, BONHAM S, DIAZ SAEZ L, Riant O, HUBER KVM, KESSLER BM, Feron O, Tate EW63:3756-3762Journal of Medicinal Chemistry10.1021/acs.jmedchem.0c0014428.02.2020
32084498Structure-based view of the druggable genome.Wang J, Yazdani S, Han A, Schapira MDrug Discov. Today10.1016/j.drudis.2020.02.00619.02.2020
32061125MichelaNglo: sculpting protein views on web pages without codingFerla MP, Pagnamenta AT, Damerell D, Taylor JC, Marsden BD36:3268-3270Bioinformatics10.1093/bioinformatics/btaa10415.02.2020
31885874Human MettL3-MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro.Woodcock CB, Yu D, Hajian T, Li J, Huang Y, Dai N, Corrêa IR, Wu T, Vedadi M, Zhang X, Cheng X5:63Cell Discov10.1038/s41421-019-0136-431.12.2019
31848333Discovery of a chemical probe for PRDM9.Allali-Hassani A, Szewczyk MM, Ivanochko D, Organ SL, Bok J, Ho JSY, Gay FPH, Li F, Blazer L, Eram MS, Halabelian L, Dilworth D, Luciani GM, Lima-Fernandes E, Wu Q, Loppnau P, Palmer N, Talib SZA, Brown PJ, Schapira M, Kaldis P, O'Hagan RC, Guccione E, Barsyte-Lovejoy D, Arrowsmith CH, Sanders JM, Kattar SD, Bennett DJ, Nicholson B, Vedadi M10(1):5759Nat Commun10.1038/s41467-019-13652-x17.12.2019
Synthesis and Biological Investigation of (+)-JD1, an Organometallic BET Bromodomain InhibitorHassell-Hart S, Runcie A, Krojer T, Doyle J, Lineham E, Ocasio CA, Neto BAD, Fedorov O, Marsh G, Maple H, Felix R, Banks R, Ciulli A, Picaud S, Filippakopoulos P, Von Delft F, Brennan P, Stewart HJS, Chevassut TJ, Walker M, Austin C, Morley S, Spencer JOrganometallics10.1021/acs.organomet.9b0075017.12.2019
31817960Methyltransferase Inhibitors: Competing with, or Exploiting the Bound Cofactor.Ferreira de Freitas R, Ivanochko D, Schapira M24(24):Molecules10.3390/molecules2424449208.12.2019
31797984Structural consequences of BMPR2 kinase domain mutations causing pulmonary arterial hypertensionBULLOCK A, Chaikuad A, Thangaratnarajah C, VON DELFT F9:18351-Scientific Reports10.1038/s41598-019-54830-704.12.2019
31809836Chemical Probes for Protein Arginine Methyltransferases.Ming Li AS, Li F, Eram MS, Bolotokova A, Dela Seña CC, Vedadi MMethods10.1016/j.ymeth.2019.11.01703.12.2019
31806353Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2 (PC2)WANG Q, COREY RA, Hedger G, Aryal P, GRIEBEN M, NASRALLAH C, Baronina A, PIKE A, Shi J, CARPENTER EP, SANSOM MSP28:169-184.e5Structure10.1016/j.str.2019.11.00502.12.2019
31781029Synthetic Peptides as Therapeutic Agents: Lessons Learned From Evolutionary Ancient Peptides and Their Transit Across Blood-Brain Barriers.Lovejoy DA, Hogg DW, Dodsworth TL, Jurado FR, Read CC, D'Aquila AL, Barsyte-Lovejoy D10:730Front Endocrinol (Lausanne)10.3389/fendo.2019.0073030.11.2019
31857843Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1Ni X, Heidenreich D, Christott T, Bennett J, Moustakim M, Brennan PE, Fedorov O, Knapp S, Chaikuad A10:1661-1666ACS Medicinal Chemistry Letters10.1021/acsmedchemlett.9b0046025.11.2019
31775019Janus kinase inhibition for autoinflammation in patients with DNASE2 deficiencyHong Y, Capitani M, Murphy C, Pandey S, Cavounidis A, Takeshita H, Nanthapisal S, Yasuda T, Bader-Meunier B, McCreary D, Omoyinmi E, Rao A, Booth C, Gilmour K, Sebire N, Shah N, Klein N, Bullock AN, Eleftheriou D, Uhlig HH, Brogan P145:701-705.e8Journal of Allergy and Clinical Immunology10.1016/j.jaci.2019.11.02024.11.2019
31806351HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells.Shukla V, Halabelian L, Balagere S, Samaniego-Castruita D, Feldman DE, Arrowsmith CH, Rao A, Aravind LMol. Cell10.1016/j.molcel.2019.10.03115.11.2019
31712618Binding and structural analyses of potent inhibitors of the human Ca<sup>2+</sup>/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitorsProfeta GS, Dos Reis CV, Santiago ADS, Godoi PHC, Fala AM, Wells CI, Sartori R, Salmazo APT, Ramos PZ, Massirer KB, Elkins JM, Drewry DH, Gileadi O, Couñago RM9:16452-Scientific reports10.1038/s41598-019-52795-111.11.2019
31726225Emerging tools to investigate bromodomain functionsKougnassoukou Tchara PE, Filippakopoulos P, Lambert JPMethods10.1016/j.ymeth.2019.11.00311.11.2019
31698822Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK)Asquith CRM, Bennett JM, Su L, Laitinen T, Elkins JM, Pickett JE, Wells CI, Li Z, Willson TM, Zuercher WJ24:-Molecules (Basel, Switzerland)10.3390/molecules2422401606.11.2019
31686052Multiple direct interactions of TBP with the MYC oncoprotein.Wei Y, Resetca D, Li Z, Johansson-Åkhe I, Ahlner A, Helander S, Wallenhammar A, Morad V, Raught B, Wallner B, Kokubo T, Tong Y, Penn LZ, Sunnerhagen MNat. Struct. Mol. Biol.10.1038/s41594-019-0321-z04.11.2019
31676788Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signallingeyres R, clarke R, FARNIE G10:5016-Nature Communications10.1038/s41467-019-12807-001.11.2019
31675459Design and Analysis of the 4-Anilinoquin(az)oline Kinase Inhibition Profiles of GAK/SLK/STK10 Using Quantitative Structure-Activity RelationshipsAsquith CRM, Laitinen T, Bennett JM, Wells CI, Elkins JM, Zuercher WJ, Tizzard GJ, Poso A15:26-49ChemMedChem10.1002/cmdc.20190052101.11.2019
31666732Targeted protein degradation: expanding the toolbox.Schapira M, Calabrese MF, Bullock AN, Crews CMNat Rev Drug Discov10.1038/s41573-019-0047-y30.10.2019
31666732Targeted protein degradation: expanding the toolboxSchapira M, Calabrese MF, Bullock AN, Crews CM18:949-963Nature Reviews Drug Discovery10.1038/s41573-019-0047-y30.10.2019
31663737Discovery of small molecule antagonists of the USP5 zinc finger ubiquitin-binding domain.Mann MK, Franzoni I, de Freitas RF, Tempel W, Houliston S, Smith L, Vedadi M, Arrowsmith CH, Harding RJ, Schapira MJ. Med. Chem.10.1021/acs.jmedchem.9b0098830.10.2019
SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2KWells C, Couñago RM, Limas JC, Almeida TL, Cook JG, Drewry DH, Elkins JM, Gileadi O, Kapadia NR, Lorente-Macias A, Pickett JE, Riemen A, Ruela-De-Sousa RR, Willson TM, Zhang C, Zuercher WJ, Zutshi R, Axtman ADACS Medicinal Chemistry Letters10.1021/acsmedchemlett.9b0039929.10.2019
31657716A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion.Cai XC, Zhang T, Kim EJ, Jiang M, Wang K, Wang J, Chen S, Zhang N, Wu H, Li F, Dela Seña CC, Zeng H, Vivcharuk V, Niu X, Zheng W, Lee JP, Chen Y, Barsyte D, Szewczyk M, Hajian T, Ibáñez G, Dong A, Dombrovski L, Zhang Z, Deng H, Min J, Arrowsmith CH, Mazutis L, Shi L, Vedadi M, Brown PJ, Xiang J, Qin LX, Xu W, Luo M8:Elife10.7554/eLife.4711028.10.2019
Re-Evaluating the Mechanism of Action of α,β-Unsaturated Carbonyl DUB Inhibitors B-AP15 and VLX1570: A Paradigmatic Example of Unspecific Protein Crosslinking with Michael Acceptor Motif-Containing DrugsWARD J, Pinto-Fernandez A, Cornelissen L, BONHAM S, DIAZ SAEZ L, Riant O, HUBER K, KESSLER B, Feron O, Tate EChemRxiv24.10.2019
31612854Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72.Laflamme C, McKeever PM, Kumar R, Schwartz J, Kolahdouzan M, Chen CX, You Z, Benaliouad F, Gileadi O, McBride HM, Durcan TM, Edwards AM, Healy LM, Robertson J, McPherson PS8:Elife10.7554/eLife.4836315.10.2019
31626811Structural basis for the recognition of non-methylated DNA by the CXXC domain.Liu K, Min JJ. Mol. Biol.10.1016/j.jmb.2019.09.02515.10.2019
31652302Lessons from LIMK1 enzymology and their impact on inhibitor designSalah E, Chatterjee D, Beltrami A, Tumber A, Preuss F, Canning P, Chaikuad A, Knaus P, Knapp S, Bullock AN, Mathea S476:3197-3209Biochemical Journal10.1042/bcj2019051713.10.2019
31768489Development of macrocycle kinase inhibitors for ALK2 using Fibrodysplasia ossificans progressiva-derived endothelial cellsBULLOCK A, WILLIAMS E, KERR G3:e10230-JBMR Plus10.1002/jbm4.1023006.10.2019
31582844Targeting non-bromodomain chromatin readers.Arrowsmith CH, Schapira M26(10):863-869Nat. Struct. Mol. Biol.10.1038/s41594-019-0290-205.10.2019
SuCOS is Better than RMSD for Evaluating Fragment Elaboration and Docking PosesLeung S, Bodkin M, von Delft F, Brennan P, Morris GChemRxiv10.26434/chemrxiv.8100203.v104.10.2019
31580259Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformationYu X, Plotnikova O, Bonin PD, Subashi TA, McLellan TJ, Dumlao D, Che Y, Dong YY, Carpenter EP, West GM, Qiu X, Culp JS, Han S8:-eLife10.7554/eLife.4812002.10.2019
31460764Modular Synthesis of Di- and Trisubstituted Imidazoles from Ketones and Aldehydes: A Route to Kinase Inhibitors.de Toledo I, Grigolo TA, Bennett JM, Elkins JM, Pilli RAJ Org Chem10.1021/acs.joc.9b0184430.09.2019
Structural consequences of BMPR2 kinase domain mutations causing pulmonary arterial hypertensionChaikuad A, Thangaratnarajah C, von Delft F, Bullock ANBiorxiv10.1101/78675629.09.2019
31559307SETD7 at the heart of chromatin factor interplay.Barsyte-Lovejoy D6:20Stem Cell Investig10.21037/sci.2019.06.0129.09.2019
31550156A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function.Fagan V, Johansson C, Gileadi C, Monteiro O, Dunford JE, Nibhani R, Philpott M, Malzahn J, Wells G, Farham R, Cribbs A, Halidi N, Li F, Chau I, Greschik H, Velupillai S, Allali-Hassani A, Bennett JM, Christott T, Giroud C, Lewis AM, Huber KVM, Athanasou N, Bountra C, Jung M, Schüle R, Vedadi M, Arrowsmith CH, Xiong Y, Jin J, Fedorov O, Farnie G, Brennan PE, Oppermann UCTJ. Med. Chem.10.1021/acs.jmedchem.9b0056224.09.2019
31551357Fostering open collaboration in drug development for paediatric brain tumoursBULLOCK A, WILLIAMS E, WONG JF, Brown EJ47:1471-1479Biochemical Society Transactions10.1042/bst2019031523.09.2019
31550156A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin FunctionFagan V, Johansson C, Gileadi C, Monteiro O, Dunford JE, Nibhani R, Philpott M, Malzahn J, Wells G, Farham R, Cribbs A, Halidi N, Li F, Chau I, Greschik H, Velupillai S, Allali-Hassani A, Bennett JM, Christott T, Giroud C, Lewis AM, Huber KVM, Athanasou N, Bountra C, Jung M, Schüle R, Vedadi M, Arrowsmith CH, Xiong Y, Jin J, Fedorov O, Farnie G, Brennan PE, Oppermann UCT62:9008-9025Journal of Medicinal Chemistry10.1021/acs.jmedchem.9b0056223.09.2019
31587830Regulation of DGKε Activity and Substrate Acyl Chain Specificity by Negatively Charged Phospholipids.Bozelli JC, Yune J, Hou YH, Chatha P, Fernandes A, Cao Z, Tong Y, Epand RMBiophys. J.10.1016/j.bpj.2019.09.00816.09.2019
31620147The C-Terminal Domains SnRK2 Box and ABA Box Have a Role in Sugarcane SnRK2s Auto-Activation and ActivityRighetto GL, Sriranganadane D, Halabelian L, Chiodi CG, Elkins JM, Massirer KB, Gileadi O, Menossi M, Couñago RM10:1105-Frontiers in Plant Science10.3389/fpls.2019.0110516.09.2019
31531195Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2Serafim RAM, De Souza Gama FH, Dutra LA, Dos Reis CV, Vasconcelos SNS, Da Silva Santiago A, Takarada JE, Di Pillo F, Azevedo H, Mascarello A, Elkins JM, Massirer KB, Gileadi O, Guimarães CRW, Couñago RM10:1266-1271ACS Medicinal Chemistry Letters10.1021/acsmedchemlett.9b0008212.09.2019
Strategies to improve scFvs as crystallization chaperones suggested by analysis of a complex with the human PHD-bromodomain SP140Fairhead M, Preger C, Wigren E, Strain-Damerell C, Ossipova E, Ye M, Makola M, Burgess-Brown NA, Persson H, von Delft F, Gräslund S10.1101/76737612.09.2019
A Chemical Probe Targeting AAK1 and BMP2KWells C, Counago R, Limas J, Almeida T, Cook J, Drewry D, Elkins J, Gileadi O, Kapadia N, Lorente-Macías Á, Pickett J, Riemen A, R. Ruela-de-Sousa R, Willson T, Zhang C, Zuercher W, Zutshi R, Axtman A10.26434/chemrxiv.9756785.v103.09.2019
31279627Structural basis for recruitment of DAPK1 to the KLHL20 E3 ligaseBULLOCK A, CHEN Z, PICAUD S, FILIPPAKOPOULOS P, D'ANGIOLELLA V27:1395-1404.e4Structure10.1016/j.str.2019.06.00503.09.2019
31504794LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA.Izumikawa K, Ishikawa H, Yoshikawa H, Fujiyama S, Watanabe A, Aburatani H, Tachikawa H, Hayano T, Miura Y, Isobe T, Simpson RJ, Li L, Min J, Takahashi NNucleic Acids Res.10.1093/nar/gkz74702.09.2019
31477691The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16KBushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP10:3956-Nature Communications10.1038/s41467-019-11753-101.09.2019
31158747C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4)inhibitors, compound profiling in cell-based target engagement assaysLe Bihan YV, Lanigan RM, Atrash B, McLaughlin MG, Velupillai S, Malcolm AG, England KS, Ruda GF, Mok NY, Tumber A, Tomlin K, Saville H, Shehu E, McAndrew C, Carmichael LA, Bennett JM, Jeganathan F, Eve P, Donovan A, Hayes A, Wood F, Raynaud FI, Fedorov O, Brennan PE, Burke R, van Montfort RLM, Rossanese OW, Blagg J, Bavetsias V177:316-337European Journal of Medicinal Chemistry10.1016/j.ejmech.2019.05.04101.09.2019
31467193Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug targetAlam MM, Sanchez-Azqueta A, Janha O, Flannery EL, Mahindra A, Mapesa K, Char AB, Sriranganadane D, Brancucci NMB, Antonova-Koch Y, Crouch K, Simwela NV, Millar SB, Akinwale J, Mitcheson D, Solyakov L, Dudek K, Jones C, Zapatero C, Doerig C, Nwakanma DC, Vázquez MJ, Colmenarejo G, Lafuente-Monasterio MJ, Leon ML, Godoi PHC, Elkins JM, Waters AP, Jamieson AG, Álvaro EF, Ranford-Cartwright LC, Marti M, Winzeler EA, Gamo FJ, Tobin AB365:884-+Science10.1126/science.aau168230.08.2019
31462754The natural history of infantile mitochondrial DNA depletion syndrome due to RRM2B deficiencyKeshavan N, Abdenur J, Anderson G, Assouline Z, Barcia G, Bouhikbar L, Chakrapani A, Cleary M, Cohen MC, Feillet F, Fratter C, Hauser N, Jacques T, Lam A, McCullagh H, Phadke R, Rötig A, Sharrard M, Simon M, Smith C, Sommerville EW, Taylor RW, Yue WW, Rahman SGenetics in Medicine10.1038/s41436-019-0613-z29.08.2019
31448096Open laboratory notebooks: good for science, good for society, good for scientists.Schapira M, Harding RJ8:87F1000Res10.12688/f1000research.17710.127.08.2019
31442339Target highlights in CASP13: experimental target structures through the eyes of their authors.Lepore R, Kryshtafovych A, Alahuhta M, Arora Veraszto H, Bomble YJ, Bufton JC, Bullock AN, Caba C, Cao H, Davies OR, Desfosses A, Dunne M, Fidelis K, Goulding CW, Gurusaran M, Gutsche I, Harding CJ, Hartmann MD, Hayes CS, Joachimiak A, Leiman PG, Loppnau P, Lovering AL, Lunin VV, Michalska K, Mir-Sanchis I, Mitra A, Moult J, Phillips GN, Pinkas DM, Rice PA, Tong Y, Topf M, Walton JD, Schwede TProteins10.1002/prot.2580523.08.2019
31386708Evaluation of linker length effects on a BET bromodomain probeTraquete R, Henderson E, Picaud S, Cal PMSD, Sieglitz F, Rodrigues T, Oliveira R, Filippakopoulos P, Bernardes GJL55:10128-10131Chemical Communications10.1039/c9cc05054j20.08.2019
31415173Selective, small molecule co-factor binding site inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax (SET) domain containing lysine methyltransferase.Taylor AP, Szewczyk MM, Kennedy S, Trush VV, Wu H, Zeng H, Dong A, de Freitas RF, Tatlock JH, Kumpf RA, Wythes M, Casimiro-Garcia A, Denny RA, Parikh MD, Li F, Barsyte-Lovejoy D, Schapira M, Vedadi M, Brown P, Arrowsmith CH, Owen DRJ. Med. Chem.10.1021/acs.jmedchem.9b0011215.08.2019
31408619Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.Fong JY, Pignata L, Goy PA, Kawabata KC, Lee SC, Koh CM, Musiani D, Massignani E, Kotini AG, Penson A, Wun CM, Shen Y, Schwarz M, Low DH, Rialdi A, Ki M, Wollmann H, Mzoughi S, Gay F, Thompson C, Hart T, Barbash O, Luciani GM, Szewczyk MM, Wouters BJ, Delwel R, Papapetrou EP, Barsyte-Lovejoy D, Arrowsmith CH, Minden MD, Jin J, Melnick A, Bonaldi T, Abdel-Wahab O, Guccione E36(2):194-209.e9Cancer Cell10.1016/j.ccell.2019.07.00312.08.2019
31400120The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions.Kaustov L, Lemak A, Wu H, Faini M, Fan L, Fang X, Zeng H, Duan S, Allali-Hassani A, Li F, Wei Y, Vedadi M, Aebersold R, Wang Y, Houliston S, Arrowsmith CHNucleic Acids Res.10.1093/nar/gkz69710.08.2019
31204252A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of UbiquitinLim M, Newman JA, Williams HL, Masino L, Aitkenhead H, Gravard AE, Gileadi O, Svejstrup JQ27:1316-1325.e6Structure10.1016/j.str.2019.05.00306.08.2019
313101252-Amino-2,3-dihydro-1H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer EfficacyZhu D, Huang H, Pinkas DM, Luo J, Ganguly D, Fox AE, Arner E, Xiang Q, Tu Z-C, Bullock AN, Brekken RA, Ding K, Lu X62:7431-7444Journal of Medicinal Chemistry10.1021/acs.jmedchem.9b0036502.08.2019
31176694Regulation of influenza A virus mRNA splicing by CLK1Artarini A, Meyer M, Shin YJ, Huber K, Hilz N, Bracher F, Eros D, Orfi L, Keri G, Goedert S, Neuenschwander M, von Kries J, Domovich-Eisenberg Y, Dekel N, Szabadkai I, Lebendiker M, Horváth Z, Danieli T, Livnah O, Moncorgé O, Frise R, Barclay W, Meyer TF, Karlas A168:187-196Antiviral Research10.1016/j.antiviral.2019.06.00301.08.2019
31356990Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain.Lei M, Tempel W, Chen S, Liu K, Min J194409Biochim Biophys Acta Gene Regul Mech10.1016/j.bbagrm.2019.19440926.07.2019
31320618Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENPAbdul Azeez KR, Chatterjee S, Yu C, Golub TR, Sobott F, Elkins JM10:3166-Nature Communications10.1038/s41467-019-11085-018.07.2019
31327677Identification and characterization of the first fragment hits for SETDB1 Tudor domain.Mader P, Mendoza-Sanchez R, Iqbal A, Dong A, Dobrovetsky E, Corless VB, Liew SK, Houliston SR, De Freitas RF, Smil D, Sena CCD, Kennedy S, Diaz DB, Wu H, Dombrovski L, Allali-Hassani A, Min J, Schapira M, Vedadi M, Brown PJ, Santhakumar V, Yudin AK, Arrowsmith CHBioorg. Med. Chem.10.1016/j.bmc.2019.07.02012.07.2019
31287992A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor.Sin-Chan P, Mumal I, Suwal T, Ho B, Fan X, Singh I, Du Y, Lu M, Patel N, Torchia J, Popovski D, Fouladi M, Guilhamon P, Hansford JR, Leary S, Hoffman LM, Mulcahy Levy JM, Lassaletta A, Solano-Paez P, Rivas E, Reddy A, Gillespie GY, Gupta N, Van Meter TE, Nakamura H, Wong TT, Ra YS, Kim SK, Massimi L, Grundy RG, Fangusaro J, Johnston D, Chan J, Lafay-Cousin L, Hwang EI, Wang Y, Catchpoole D, Michaud J, Ellezam B, Ramanujachar R, Lindsay H, Taylor MD, Hawkins CE, Bouffet E, Jabado N, Singh SK, Kleinman CL, Barsyte-Lovejoy D, Li XN, Dirks PB, Lin CY, Mack SC, Rich JN, Huang A36(1):51-67.e7Cancer Cell10.1016/j.ccell.2019.06.00208.07.2019
31285596Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.Böttcher J, Dilworth D, Reiser U, Neumüller RA, Schleicher M, Petronczki M, Zeeb M, Mischerikow N, Allali-Hassani A, Szewczyk MM, Li F, Kennedy S, Vedadi M, Barsyte-Lovejoy D, Brown PJ, Huber KVM, Rogers CM, Wells CI, Fedorov O, Rumpel K, Zoephel A, Mayer M, Wunberg T, Böse D, Zahn S, Arnhof H, Berger H, Reiser C, Hörmann A, Krammer T, Corcokovic M, Sharps B, Winkler S, Häring D, Cockcroft XL, Fuchs JE, Müllauer B, Weiss-Puxbaum A, Gerstberger T, Boehmelt G, Vakoc CR, Arrowsmith CH, Pearson M, McConnell DBNat. Chem. Biol.10.1038/s41589-019-0310-x08.07.2019
31295578Peptide Hydrogels of Fully-Defined Composition & Mechanics for Probing Cell-Cell & Cell-Matrix Interactions In VitroAshworth J, Thompsona J, Jamesa J, Slatera C, Pijuan-Galitoa S, Lis-Slimaka K, Holleyc R, Mead K, Thompsone A, Arkille K, Tassierif M, Wrightg A, FARNIE G, merry CMatrix Biology10.1016/j.matbio.2019.06.00908.07.2019
31288074Lesson from a Fab-enabled co-crystallization study of TDRD2 and PIWIL1.Chen S, Zhang W, Min J, Liu KMethods10.1016/j.ymeth.2019.07.00206.07.2019
31278990Target 2035: probing the human proteome.Carter AJ, Kraemer O, Zwick M, Mueller-Fahrnow A, Arrowsmith CH, Edwards AMDrug Discov. Today10.1016/j.drudis.2019.06.02003.07.2019
31267458High-throughput site-directed mutagenesisStrain-Damerell C, Burgess-Brown NA2025:281-296Methods Mol Biol10.1007/978-1-4939-9624-7_1303.07.2019
31260300Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1).Xiong Y, Greschik H, Johansson C, Seifert L, Bacher J, Park KS, Babault N, Martini ML, Fagan V, Li F, Chau I, Christott T, Dilworth D, Barsyte-Lovejoy D, Vedadi M, Arrowsmith CH, Brennan PE, Fedorov O, Jung M, Farnie G, Liu J, Oppermann UCT, Schüle R, Jin JJ. Med. Chem.10.1021/acs.jmedchem.9b0052201.07.2019
31104332Increased EZH2 expression in prostate cancer is associated with metastatic recurrence following external beam radiotherapyWu X, Scott H, Carlsson SV, Sjoberg DD, Cerundolo L, Lilja H, Prevo R, Rieunier G, Macaulay V, Higgins GS, Verrill CL, Lamb AD, Cunliffe VT, Bountra C, Hamdy FC, Bryant RJ79:1079-1089The Prostate10.1002/pros.2381701.07.2019
31250316Streamlining the production of proteins for structural biologyOwens RJ, Gileadi O11:533-534Biophysical Reviews10.1007/s12551-019-00565-827.06.2019
31239348Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.El Bakkouri M, Kouidmi I, Wernimont AK, Amani M, Hutchinson A, Loppnau P, Kim JJ, Flueck C, Walker JR, Seitova A, Senisterra G, Kakihara Y, Kim C, Blackman MJ, Calmettes C, Baker DA, Hui RProc. Natl. Acad. Sci. U.S.A.10.1073/pnas.190555811625.06.2019
31235913Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition.Halabelian L, Ravichandran M, Li Y, Zeng H, Rao A, Aravind L, Arrowsmith CHNat. Struct. Mol. Biol.10.1038/s41594-019-0246-624.06.2019
31136173Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral ActivityVerdonck S, Pu SY, Sorrell FJ, Elkins JM, Froeyen M, Gao LJ, Prugar LI, Dorosky DE, Brannan JM, Barouch-Bentov R, Knapp S, Dye JM, Herdewijn P, Einav S, De Jonghe S62:5810-5831Journal of Medicinal Chemistry10.1021/acs.jmedchem.9b0013612.06.2019
31177572Expanding the genetic and phenotypic spectrum of branched-chain amino acid transferase 2 deficiencyKnerr I, Colombo R, Urquhart J, Morais A, Merinero B, Oyarzabal A, Pérez B, Jones SA, Perveen R, Preece MA, Rogers Y, Treacy EP, Mayne P, Zampino G, MacKinnon S, Wassmer E, Yue WW, Robinson I, Rodríguez-Pombo P, Olpin SE, Banka S42:809-817Journal of Inherited Metabolic Disease10.1002/jimd.1213508.06.2019
31175292Structural and functional consequences of the STAT5BN642H driver mutation.de Araujo ED, Erdogan F, Neubauer HA, Meneksedag-Erol D, Manaswiyoungkul P, Eram MS, Seo HS, Qadree AK, Israelian J, Orlova A, Suske T, Pham HTT, Boersma A, Tangermann S, Kenner L, Rülicke T, Dong A, Ravichandran M, Brown PJ, Audette GF, Rauscher S, Dhe-Paganon S, Moriggl R, Gunning PT10(1):2517Nat Commun10.1038/s41467-019-10422-707.06.2019
31060360Rapid Covalent-Probe Discovery by Electrophile-Fragment ScreeningResnick E, Bradley A, Gan J, Douangamath A, Krojer T, Sethi R, Geurink PP, Aimon A, Amitai G, Bellini D, Bennett J, Fairhead M, Fedorov O, Gabizon R, Gan J, Guo J, Plotnikov A, Reznik N, Ruda GF, Díaz-Sáez L, Straub VM, Szommer T, Velupillai S, Zaidman D, Zhang Y, Coker AR, Dowson CG, Barr HM, Wang C, Huber KVM, Brennan PE, Ovaa H, von Delft F, London N141:8951-8968Journal of the American Chemical Society10.1021/jacs.9b0282205.06.2019
30682498Genetic, structural, and functional analysis of pathogenic variations causing methylmalonyl-CoA epimerase deficiencyHeuberger K, Bailey HJ, Burda P, Chaikuad A, Krysztofinska E, Suormala T, Bürer C, Lutz S, Fowler B, Froese DS, Yue WW, Baumgartner MR1865:1265-1272Biochimica et Biophysica Acta - Molecular Basis of Disease10.1016/j.bbadis.2019.01.02101.06.2019
3112371215-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism.Abis G, Charles RL, Kopec J, Yue WW, Atkinson RA, Bui TTT, Lynham S, Popova S, Sun Y-B, Fraternali F, Eaton P, Conte MR2:188-188Communications biology10.1038/s42003-019-0426-217.05.2019
31101807Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanismFox NG, Yu X, Feng X, Bailey HJ, Martelli A, Nabhan JF, Strain-Damerell C, Bulawa C, Yue WW, Han S10:2210-Nature Communications10.1038/s41467-019-09989-y17.05.2019
31081496The dynamic conformational landscape of the protein methyltransferase SETD8.Chen S, Wiewiora RP, Meng F, Babault N, Ma A, Yu W, Qian K, Hu H, Zou H, Wang J, Fan S, Blum G, Pittella-Silva F, Beauchamp KA, Tempel W, Jiang H, Chen K, Skene RJ, Zheng YG, Brown PJ, Jin J, Luo C, Chodera JD, Luo M8:Elife10.7554/eLife.4540313.05.2019
31026091Construction of a Shape‐Diverse Fragment Set: Design, Synthesis and Screen against Aurora‐A KinaseZhang R, McIntyre PJ, Collins PM, Foley DJ, Arter C, von Delft F, Bayliss R, Warriner S, Nelson A25:6831-6839Chemistry – A European Journal10.1002/chem.20190081510.05.2019
30998845Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain.Huang L, Li H, Li L, Niu L, Seupel R, Wu C, Cheng W, Chen C, Ding B, Brennan PE, Yang S62:4526-4542Journal of medicinal chemistry10.1021/acs.jmedchem.9b0009609.05.2019
31098401ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine gliomaCarvalho D, Taylor KR, Olaciregui NG, Molinari V, Clarke M, Mackay A, Ruddle R, Henley A, Valenti M, Hayes A, Brandon ADH, Eccles SA, Raynaud F, Boudhar A, Monje M, Popov S, Moore AS, Mora J, Cruz O, Vinci M, Brennan PE, Bullock AN, Carcaboso AM, Jones C2:156-Communications Biology10.1038/s42003-019-0420-809.05.2019
31046474Structure and function of eTudor domain containing TDRD proteins.Gan B, Chen S, Liu H, Min J, Liu K1-14Crit. Rev. Biochem. Mol. Biol.10.1080/10409238.2019.160319903.05.2019
30663059Identification of a novel biomarker for pyridoxine-dependent epilepsy: Implications for newborn screeningWempe MF, Kumar A, Kumar V, Choi YJ, Swanson MA, Friederich MW, Hyland K, Yue WW, Van Hove JLK, Coughlin CR42:565-574Journal of Inherited Metabolic Disease10.1002/jimd.1205901.05.2019
31030650Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mappingThomas SE, Collins P, James RH, Mendes V, Charoensutthivarakul S, Radoux C, Abell C, Coyne AG, Floto RA, von Delft F, Blundell TL377:20180422-20180422Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences10.1098/rsta.2018.042229.04.2019
30991936Crystal structure of human RIOK2 bound to a specific inhibitorWang J, Varin T, Vieth M, Elkins JM9:190037-Open Biology10.1098/rsob.19003726.04.2019
31054975Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins.Ali I, Ruiz DG, Ni Z, Johnson JR, Zhang H, Li PC, Khalid MM, Conrad RJ, Guo X, Min J, Greenblatt J, Jacobson M, Krogan NJ, Ott MMol. Cell10.1016/j.molcel.2019.04.00826.04.2019
31024026Discovery of selective activators of PRC2 mutant EED-I363M.Suh JL, Barnash KD, Abramyan TM, Li F, The J, Engelberg IA, Vedadi M, Brown PJ, Kireev DB, Arrowsmith CH, James LI, Frye SV9(1):6524Sci Rep10.1038/s41598-019-43005-z25.04.2019
31015424A chemical toolbox for the study of bromodomains and epigenetic signaling.Wu Q, Heidenreich D, Zhou S, Ackloo S, Krämer A, Nakka K, Lima-Fernandes E, Deblois G, Duan S, Vellanki RN, Li F, Vedadi M, Dilworth J, Lupien M, Brennan PE, Arrowsmith CH, Müller S, Fedorov O, Filippakopoulos P, Knapp S10(1):1915Nat Commun10.1038/s41467-019-09672-223.04.2019
30980593Structural analyses reveal that MBD3 is a methylated-CG binder.Liu K, Lei M, Wu Z, Gan B, Cheng H, Li Y, Min JFEBS J.10.1111/febs.1485013.04.2019
30976796Structural insights into the modulatory role of the accessory protein WYL1 in the Type VI-D CRISPR-Cas system.Zhang H, Dong C, Li L, Wasney GA, Min JNucleic Acids Res.10.1093/nar/gkz26912.04.2019
30973712Chromokinesins NOD and KID Use Distinct ATPase Mechanisms and Microtubule Interactions to Perform a Similar Function.Walker BC, Tempel W, Zhu H, Park HW, Cochran JCBiochemistry10.1021/acs.biochem.9b0001111.04.2019
30996803Identification of the 2-Benzoxazol-2-yl-phenol Scaffold as New Hit for JMJD3 Inhibition.Giordano, A; Forte, G; Terracciano, S; Russo, A; Sala, M; Scala, MC; Johansson, C; Oppermann, U; Riccio, R; Bruno, I; Di Micco, S; 10:601-605ACS Medicinal Chemistry Letters10.1021/acsmedchemlett.8b0058901.4.2019
30970244A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric ComplexMarabelli C, Marrocco B, Pilotto S, Chittori S, Picaud S, Marchese S, Ciossani G, Forneris F, Filippakopoulos P, Schoehn G, Rhodes D, Subramaniam S, Mattevi A27:387-399.e7Cell Reports10.1016/j.celrep.2019.03.06109.04.2019
30962579Development and preclinical validation of a novel covalent ubiquitin receptor Rpn13 degrader in multiple myelomaSong Y, Park PMC, Wu L, Ray A, Picaud S, Li D, Wimalasena VK, Du T, Filippakopoulos P, Anderson KC, Qi J, Chauhan DLeukemia10.1038/s41375-019-0467-z08.04.2019
30962627Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming.Ebrahimi, A; Sevinç, K; Gürhan Sevinç, G; Cribbs, AP; Philpott, M; Uyulur, F; Morova, T; Dunford, JE; Göklemez, S; Arı, Ş; Oppermann, U; Önder, TT; :-Nature Chemical Biology10.1038/s41589-019-0264-z8.4.2019
30984471A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratasePfeiffer M, Johansson C, Krojer T, Kavanagh KL, Oppermann U, Nidetzky B9:2962-2968ACS Catalysis10.1021/acscatal.9b0006405.04.2019
30858169Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in cisSorrell FJ, Kilian LM, Elkins JM476:1037-1051Biochemical Journal10.1042/BCJ2018086704.04.2019
30940287Simultaneous Detection of 13 Allergens in Thermally Processed Food Using Targeted LC-MS/MS Approach.Ogura, T; Clifford, R; Oppermann, U; :-Journal of AOAC INTERNATIONAL10.5740/jaoacint.19-00602.4.2019
30853107Role of protein structure in variant annotation: structural insight of mutations causing 6-pyruvoyl-tetrahydropterin synthase deficiencyMuniz JRC, Szeto NW-S, Frise R, Lee WH, Wang X-S, Thöny B, Himmelreich N, Blau N, Hsiao K-J, Liu T-T, Gileadi O, Oppermann U, Von Delft F, Yue WW, Tang NL-S51:274-280Pathology10.1016/j.pathol.2018.11.01101.04.2019
30926792Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells.Lima-Fernandes E, Murison A, da Silva Medina T, Wang Y, Ma A, Leung C, Luciani GM, Haynes J, Pollett A, Zeller C, Duan S, Kreso A, Barsyte-Lovejoy D, Wouters BG, Jin J, Carvalho DD, Lupien M, Arrowsmith CH, O'Brien CA10(1):1436Nat Commun10.1038/s41467-019-09309-429.03.2019
30914461Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X.Paudel P, Zhang Q, Leung C, Greenberg HC, Guo Y, Chern YH, Dong A, Li Y, Vedadi M, Zhuang Z, Tong YProc. Natl. Acad. Sci. U.S.A.10.1073/pnas.181502711626.03.2019
30894683AKT drives SOX2 overexpression and cancer cell stemness in esophageal cancer by protecting SOX2 from UBR5-mediated degradation.Wang Z, Kang L, Zhang H, Huang Y, Fang L, Li M, Brown PJ, Arrowsmith CH, Li J, Wong JOncogene10.1038/s41388-019-0790-x20.03.2019
30869179Targeting the Small GTPase Superfamily through their Regulatory Proteins.Gray, JL; von Delft, F; Brennan, P; :-Angewandte Chemie International Edition10.1002/anie.20190058514.3.2019
30867043Divergent roles of prostacyclin and PGE2 in human tendinopathy.Bergqvist, F; Carr, AJ; Wheway, K; Watkins, B; Oppermann, U; Jakobsson, P-J; Dakin, SG; 21:74-Arthritis Research10.1186/s13075-019-1855-513.3.2019
30885509Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder.Roberts, NA; Hilton, EN; Lopes, FM; Singh, S; Randles, MJ; Gardiner, NJ; Chopra, K; Coletta, R; Bajwa, Z; Hall, RJ; Yue, WW; Schaefer, F; Weber, S; Henriksson, R; Stuart, HM; Hedman, H; Newman, WG; Woolf, AS; :-Kidney International10.1016/j.kint.2018.11.0408.3.2019
30842263Design and characterization of mutant and wild-type huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems.Harding RJ, Loppnau P, Ackloo S, Lemak A, Hutchinson A, Hunt B, Holehouse AS, Ho JC, Fan L, Toledo-Sherman L, Seitova A, Arrowsmith CHJ. Biol. Chem.10.1074/jbc.RA118.00720406.03.2019
30838376Organizational innovation for developing new medicines that target aging and age-related conditions.Ford, GA; Lord, JM; Ferguson, MA; Bountra, C; Le Couteur, DG; :-Journals of Gerontology, Series A10.1093/gerona/glz0626.3.2019
Presence of Amine Oxidase 3 and its Role in Peritoneal Endometriosis Lesions.De Leo, B; Thezenas, ML; Zondervan, KT; Becker, CM; Zollner, TM; Laux-Biehlmann, A; Kessler, BM; Oppermann, U; 26:130A-130AReproductive Sciences01.3.2019
Alternative Angiogenesis Mechanisms in Uterine Fibroids Related to Heavy Menstrual Bleeding.Subramaniam, KS; Tapmeier, TT; Wang, C-Y; O'Brien, D; Philpott, M; Manek, S; Lindenthal, B; Obendorf, M; de Leo, B; Hess-Stumpp, H; Zollner, TM; Macaulay, V; Kessler, B; Zondervan, KT; Oppermann, U; Harris, A; Becker, CM; 26:226A-227AReproductive Sciences01.3.2019
30768268SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK).Asquith, CRM; Berger, B-T; Wan, J; Bennett, JM; Capuzzi, SJ; Crona, DJ; Drewry, DH; East, MP; Elkins, JM; Fedorov, O; Godoi, PH; Hunter, DM; Knapp, S; Müller, S; Torrice, CD; Wells, CI; Earp, HS; Willson, TM; Zuercher, WJ; 62:2830-2836Journal of Medicinal Chemistry10.1021/acs.jmedchem.8b0121301.3.2019
30792303A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels.Schewe, M; Sun, H; Mert, Ü; Mackenzie, A; Pike, ACW; Schulz, F; Constantin, C; Vowinkel, KS; Conrad, LJ; Kiper, AK; Gonzalez, W; Musinszki, M; Tegtmeier, M; Pryde, DC; Belabed, H; Nazare, M; de Groot, BL; Decher, N; Fakler, B; Carpenter, EP; Tucker, SJ; Baukrowitz, T; 363:875-880Science10.1126/science.aav056901.2.2019
30785395Structural insights into SETD3-mediated histidine methylation on β-actin.Guo Q, Liao S, Kwiatkowski S, Tomaka W, Yu H, Wu G, Tu X, Min J, Drozak J, Xu C8:Elife10.7554/eLife.4367620.02.2019
30774623Teneurin C-Terminal Associated Peptide (TCAP)-1 and Latrophilin Interaction in HEK293 Cells: Evidence for Modulation of Intercellular Adhesion.Husić M, Barsyte-Lovejoy D, Lovejoy DA10:22Front Endocrinol (Lausanne)10.3389/fendo.2019.0002219.02.2019
Understanding Protein-Lipid Interactions of TRP Channels of the Polycystin Family, through MD Simulations and Structural StudiesWang, Q; Hedger, G; Aryal, P; Grieben, M; Pike, ACW; Shi, J; Carpenter, EP; Sansom, MSP; 116:534A-535ABiophysical Journal10.1016/j.bpj.2018.11.287715.2.2019
30755416Response to: 'Potential roles for tenascin in (very) early diagnosis and treatment of rheumatoid arthritis' by Cutolo et al.Aungier, S; Cartwright, AJ; Schwenzer, A; Marshall, J; Dyson, MR; Slavny, P; Parthiban, K; Karatt-Vellatt, A; Sahbudin, I; Culbert, E; Hextall, P; Clanchy, FI; Williams, R; Marsden, BD; Raza, K; Filer, A; Buckley, CD; McCafferty, J; Midwood, KS; :-Annals of the Rheumatic Diseases10.1136/annrheumdis-2019-21510812.2.2019
30769091AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells.Nikolaou, N; Gathercole, LL; Kirkwood, L; Dunford, JE; Hughes, BA; Gilligan, LC; Oppermann, U; Penning, TM; Arlt, W; Hodson, L; Tomlinson, JW; 189:218-227Journal of Steroid Biochemistry and Molecular Biology10.1016/j.jsbmb.2019.02.00212.2.2019
30740661Microglial inflammation and phagocytosis in Alzheimer's disease: potential therapeutic targets.Nizami S, Hall-Roberts H, Warrier S, Cowley SA, Di Daniel E.Br J Pharmacolhttps://doi.org/10.1111/bph.1461810/02/2019
30705971Ideation and implementation of an open science drug discovery business model - M4K Pharma.Morgan MR, Roberts OG, Edwards AM3:154Wellcome Open Res10.12688/wellcomeopenres.14947.102.02.2019
30476623A novel high-content imaging-based technique for measuring binding of Dickkopf-1 to low-density lipoprotein receptor-related protein 6.Priestley RS, Cheung J, Murphy EJ, Ehebauer MT, Davis JB, Di Daniel E.95:47-55J Pharmacol Toxicol Methodshttps://doi.org/10.1016/j.vascn.2018.11.00302/02/2019
30552174Targeting early changes in the synovial microenvironment: a new class of immunomodulatory therapy?Aungier, SR; Cartwright, AJ; Schwenzer, A; Marshall, JL; Dyson, MR; Slavny, P; Parthiban, K; Karatt-Vellatt, A; Sahbudin, I; Culbert, E; Hextall, P; Clanchy, FI; Williams, R; Marsden, BD; Raza, K; Filer, A; Buckley, CD; McCafferty, J; Midwood, KS; 78:186-191Annals of the Rheumatic Diseases10.1136/annrheumdis-2018-21429401.2.2019
30679438Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.Whitesell L, Robbins N, Huang DS, McLellan CA, Shekhar-Guturja T, LeBlanc EV, Nation CS, Hui R, Hutchinson A, Collins C, Chatterjee S, Trilles R, Xie JL, Krysan DJ, Lindquist S, Porco JA, Tatu U, Brown LE, Pizarro J, Cowen LE10(1):402Nat Commun10.1038/s41467-018-08248-w24.01.2019
30665874Alterations on growth and cell organization of Giardia intestinalis trophozoites after treatment with KH-TFMDI, a novel class III histone deacetylase inhibitor.Gadelha, APR; Bravim, B; Vidal, J; Reignault, LC; Cosme, B; Huber, K; Bracher, F; de Souza, W; 309:130-142International Journal of Medical Microbiology10.1016/j.ijmm.2019.01.00201.3.2019
308816094'-Phosphopantetheine and long acyl chain-dependent interactions are integral to human mitochondrial acyl carrier protein function.Majmudar, JD; Feng, X; Fox, NG; Nabhan, JF; Towle, T; Ma, T; Gooch, R; Bulawa, C; Yue, WW; Martelli, A; 10:209-220MedChemComm10.1039/c8md00489g01.2.2019
30604749Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.Liu Y, Qin S, Chen TY, Lei M, Dhar SS, Ho JC, Dong A, Loppnau P, Li Y, Lee MG, Min J10(1):36Nat Commun10.1038/s41467-018-07906-303.01.2019
30604761A chemical biology toolbox to study protein methyltransferases and epigenetic signaling.Scheer S, Ackloo S, Medina TS, Schapira M, Li F, Ward JA, Lewis AM, Northrop JP, Richardson PL, Kaniskan HÜ, Shen Y, Liu J, Smil D, McLeod D, Zepeda-Velazquez CA, Luo M, Jin J, Barsyte-Lovejoy D, Huber KVM, De Carvalho DD, Vedadi M, Zaph C, Brown PJ, Arrowsmith CH10(1):19Nat Commun10.1038/s41467-018-07905-403.01.2019
30601939UbiHub: a data hub for the explorers of ubiquitination pathways.Liu L, Damerell DR, Koukouflis L, Tong Y, Marsden BD, Schapira MBioinformatics10.1093/bioinformatics/bty106702.01.2019
30589164An Activity-Based Probe Targeting Non-Catalytic, Highly Conserved Amino Acid Residues within Bromodomains.D'Ascenzio, M; Pugh, KM; Konietzny, R; Berridge, G; Tallant, C; Hashem, S; Monteiro, O; Thomas, JR; Schirle, M; Knapp, S; Marsden, B; Fedorov, O; Bountra, C; Kessler, BM; Brennan, PE; 58:1007-1012Angewandte Chemie International Edition10.1002/anie.20180782501.1.2019
Managing, mining and visualizing open-access structural and chemical biology dataMARSDEN B.:-01.01.2019
30554943Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.Lambert, J-P; Picaud, S; Fujisawa, T; Hou, H; Savitsky, P; Uusküla-Reimand, L; Gupta, GD; Abdouni, H; Lin, Z-Y; Tucholska, M; Knight, JDR; Gonzalez-Badillo, B; St-Denis, N; Newman, JA; Stucki, M; Pelletier, L; Bandeira, N; Wilson, MD; Filippakopoulos, P; Gingras, A-C; 73:621-638.e17Molecular Cell10.1016/j.molcel.2018.11.00601.2.2019
30431220Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.Vazquez-Rodriguez, S; Wright, M; Rogers, CM; Cribbs, AP; Velupillai, S; Philpott, M; Lee, H; Dunford, JE; Huber, KVM; Robers, MB; Vasta, JD; Thezenas, M-L; Bonham, S; Kessler, B; Bennett, J; Fedorov, O; Raynaud, F; Donovan, A; Blagg, J; Bavetsias, V; Oppermann, U; Bountra, C; Kawamura, A; Brennan, PE; 58:515-519Angewandte Chemie International Edition10.1002/anie.20181017901.1.2019
30427558Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding.Thinnes, CC; Lohans, CT; Abboud, MI; Yeh, T-L; Tumber, A; Nowak, RP; Attwood, M; Cockman, ME; Oppermann, U; Loenarz, C; Schofield, CJ; 25:2019-2024Chemistry - A European Journal10.1002/chem.20180479001.2.2019
30389497Oxidation resistance 1 regulates post-translational modifications of peroxiredoxin 2 in the cerebellum.Svistunova, DM; Simon, JN; Rembeza, E; Crabtree, M; Yue, WW; Oliver, PL; Finelli, MJ; 130:151-162Free Radical Biology and Medicine10.1016/j.freeradbiomed.2018.10.44701.1.2019
30359161Discovery of a Selective Inhibitor for the YEATS Domains of ENL/AF9.Christott, T; Bennett, J; Coxon, C; Monteiro, O; Giroud, C; Beke, V; Felce, SL; Gamble, V; Gileadi, C; Poda, G; Al-Awar, R; Farnie, G; Fedorov, O; 24:133-141Slas Discovery10.1177/247255521880990401.2.2019
29982288SATurn: a modular bioinformatics framework for the design of robust maintainable web-based and standalone applications.Damerell, DR; Strain-Damerell, C; Garsot, S; Joyce, SP; Barrett, P; Marsden, BD; 35:349-351Bioinformatics10.1093/bioinformatics/bty54901.1.2019
30605688WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop.Agajanian, MJ; Walker, MP; Axtman, AD; Ruela-de-Sousa, RR; Serafin, DS; Rabinowitz, AD; Graham, DM; Ryan, MB; Tamir, T; Nakamichi, Y; Gammons, MV; Bennett, JM; Couñago, RM; Drewry, DH; Elkins, JM; Gileadi, C; Gileadi, O; Godoi, PH; Kapadia, N; Müller, S; Santiago, AS; Sorrell, FJ; Wells, CI; Fedorov, O; Willson, TM; Zuercher, WJ; Major, MB; 26:79-93.e8Cell Reports10.1016/j.celrep.2018.12.02301.1.2019
30517884Guiding COMPASS: Dpy-30 Positions SET1/MLL Epigenetic Signaling.Dilworth D, Arrowsmith CH26(12):1567-1570Structure10.1016/j.str.2018.11.01004.12.2018
30477550Arginine does not rescue p.Q188R mutation deleterious effect in classic galactosemia.Haskovic, M; Derks, B; van der Ploeg, L; Trommelen, J; Nyakayiru, J; van Loon, LJC; Mackinnon, S; Yue, WW; Peake, RWA; Zha, L; Demirbas, D; Qi, W; Huang, X; Berry, GT; Achten, J; Bierau, J; Rubio-Gozalbo, ME; Coelho, AI; 13:212-Orphanet Journal of Rare Diseases10.1186/s13023-018-0954-826.11.2018
30407816Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL).Heidenreich, D; Moustakim, M; Schmidt, J; Merk, D; Brennan, PE; Fedorov, O; Chaikuad, A; Knapp, S; 61:10929-10934Journal of Medicinal Chemistry10.1021/acs.jmedchem.8b0145701.12.2018
30471255Allosteric Modulation of Binding Specificity by Alternative Packing of Protein Cores.Ben-David M, Huang H, Sun MGF, Corbi-Verge C, Petsalaki E, Liu K, Gfeller D, Garg P, Tempel W, Sochirca I, Shifman JM, Davidson A, Min J, Kim PM, Sidhu SSJ. Mol. Biol.10.1016/j.jmb.2018.11.01821.11.2018
30462309Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.Ivanochko D, Halabelian L, Henderson E, Savitsky P, Jain H, Marcon E, Duan S, Hutchinson A, Seitova A, Barsyte-Lovejoy D, Filippakopoulos P, Greenblatt J, Lima-Fernandes E, Arrowsmith CHNucleic Acids Res.10.1093/nar/gky119220.11.2018
30462309Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.Ivanochko, D; Halabelian, L; Henderson, E; Savitsky, P; Jain, H; Marcon, E; Duan, S; Hutchinson, A; Seitova, A; Barsyte-Lovejoy, D; Filippakopoulos, P; Greenblatt, J; Lima-Fernandes, E; Arrowsmith, CH; :-Nucleic Acids Research10.1093/nar/gky119220.11.2018
30417120An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2.Dong C, Dong G, Li L, Zhu L, Tempel W, Liu Y, Huang R, Min J1:183Commun Biol10.1038/s42003-018-0196-213.11.2018
30388443Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design.Dong, YY; Wang, H; Pike, ACW; Cochrane, SA; Hamedzadeh, S; Wyszyński, FJ; Bushell, SR; Royer, SF; Widdick, DA; Sajid, A; Boshoff, HI; Park, Y; Lucas, R; Liu, W-M; Lee, SS; Machida, T; Minall, L; Mehmood, S; Belaya, K; Liu, W-W; Chu, A; Shrestha, L; Mukhopadhyay, SMM; Strain-Damerell, C; Chalk, R; Burgess-Brown, NA; Bibb, MJ; Barry Iii, CE; Robinson, CV; Beeson, D; Davis, BG; Carpenter, EP; 175:1045-1058.e16Cell10.1016/j.cell.2018.10.03701.11.2018
30415952MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.Kalkat M, Resetca D, Lourenco C, Chan PK, Wei Y, Shiah YJ, Vitkin N, Tong Y, Sunnerhagen M, Done SJ, Boutros PC, Raught B, Penn LZMol. Cell10.1016/j.molcel.2018.09.03130.10.2018
30374165Identification of a cellularly active SIRT6 allosteric activator.Huang Z, Zhao J, Deng W, Chen Y, Shang J, Song K, Zhang L, Wang C, Lu S, Yang X, He B, Min J, Hu H, Tan M, Xu J, Zhang Q, Zhong J, Sun X, Mao Z, Lin H, Xiao M, Chin YE, Jiang H, Xu Y, Chen G, Zhang JNat. Chem. Biol.10.1038/s41589-018-0150-029.10.2018
30356213Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis.Bilyard, MK; Bailey, HJ; Raich, L; Gafitescu, MA; Machida, T; Iglésias-Fernández, J; Lee, SS; Spicer, CD; Rovira, C; Yue, WW; Davis, BG; 563:235-240Nature10.1038/s41586-018-0644-701.11.2018
30352278Characterization of inv(3) cell line OCI-AML-20 with stroma dependent CD34 expression.Luciani GM, Xie L, Dilworth D, Tierens A, Moskovitz Y, Murison A, Szewczyk MM, Mitchell A, Lupien M, Shlush L, Dick JE, Arrowsmith CH, Barsyte-Lovejoy D, Minden MDExp. Hematol.10.1016/j.exphem.2018.10.00620.10.2018
30318155Arginine methylation of FOXP3 is crucial for the suppressive function of regulatory T cells.Kagoya Y, Saijo H, Matsunaga Y, Guo T, Saso K, Anczurowski M, Wang CH, Sugata K, Murata K, Butler MO, Arrowsmith CH, Hirano NJ. Autoimmun.10.1016/j.jaut.2018.09.01111.10.2018
30300580MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis.Tu WB, Shiah YJ, Lourenco C, Mullen PJ, Dingar D, Redel C, Tamachi A, Ba-Alawi W, Aman A, Al-Awar R, Cescon DW, Haibe-Kains B, Arrowsmith CH, Raught B, Boutros PC, Penn LZ34(4):579-595.e8Cancer Cell10.1016/j.ccell.2018.09.00108.10.2018
30288907Discovery of an MLLT1/3 YEATS Domain Chemical Probe.Moustakim, M; Christott, T; Monteiro, OP; Bennett, J; Giroud, C; Ward, J; Rogers, CM; Smith, P; Panagakou, I; Díaz-Sáez, L; Felce, SL; Gamble, V; Gileadi, C; Halidi, N; Heidenreich, D; Chaikuad, A; Knapp, S; Huber, KVM; Farnie, G; Heer, J; Manevski, N; Poda, G; Al-Awar, R; Dixon, DJ; Brennan, PE; Fedorov, O; 57:16302-16307Angewandte Chemie International Edition10.1002/anie.20181061701.12.2018
30287839Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific InhibitorsSantiago, ADS; Couñago, R; Zonzini Ramos, P; Godoi, PHC; Massirer, KB; Gileadi, O; Elkins, J; :-Scientific Reports10.1101/2927974.10.2018
The structural basis for forkhead box family specificity revealed by the crystal structure of human FOXN1 in complex with DNANewman, J; Aitkenhead, H; Gavard, A; Rota, I; Handel, A; Hollander, G; Gileadi, O; :-10.1101/42801126.9.2018
30216042Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors.Stefaniak, J; Lewis, AM; Conole, D; Galan, SRG; Bataille, CJR; Wynne, GM; Castaldi, MP; Lundbäck, T; Russell, AJ; Huber, KVM; 13:2849-2854ACS Chemical Biology10.1021/acschembio.8b0066501.10.2018
Design, Synthesis and Characterization of Covalent KDM5 InhibitorsVazquez-Rodriguez, S; Wright, M; Rogers, C; Cribbs, A; Velupillai, S; Philpott, M; Lee, H; Dunford, J; Huber, K; Robers, M; Vasta, J; Thezenas, M-L; Bonham, S; Kessler, B; Bennett, J; Fedorov, O; Raynaud, F; Donovan, A; Blagg, J; Bavetsias, V; Oppermann, U; Kawamura, A; Brennan, P; :-10.26434/chemrxiv.707259211.9.2018
30185673Guaiacol as a drug candidate for treating adult polyglucosan body disease.Kakhlon, O; Ferreira, I; Solmesky, LJ; Khazanov, N; Lossos, A; Alvarez, R; Yetil, D; Pampou, S; Weil, M; Senderowitz, H; Escriba, P; Yue, WW; Akman, HO; 3:-JCI insight10.1172/jci.insight.996946.9.2018
30257209Nut Directs p300-Dependent, Genome-Wide H4 Hyperacetylation in Male Germ Cells.Shiota, H; Barral, S; Buchou, T; Tan, M; Couté, Y; Charbonnier, G; Reynoird, N; Boussouar, F; Gérard, M; Zhu, M; Bargier, L; Puthier, D; Chuffart, F; Bourova-Flin, E; Picaud, S; Filippakopoulos, P; Goudarzi, A; Ibrahim, Z; Panne, D; Rousseaux, S; Zhao, Y; Khochbin, S; 24:3477-3487.e6Cell Reports10.1016/j.celrep.2018.08.06901.9.2018
30026309Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling.Hrdinka, M; Schlicher, L; Dai, B; Pinkas, DM; Bufton, JC; Picaud, S; Ward, JA; Rogers, C; Suebsuwong, C; Nikhar, S; Cuny, GD; Huber, KV; Filippakopoulos, P; Bullock, AN; Degterev, A; Gyrd-Hansen, M; 37:-EMBO Journal10.15252/embj.20189937201.9.2018
30102854Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains.Wang, J; Erazo, T; Ferguson, FM; Buckley, DL; Gomez, N; Muñoz-Guardiola, P; Diéguez-Martínez, N; Deng, X; Hao, M; Massefski, W; Fedorov, O; Offei-Addo, NK; Park, PM; Dai, L; DiBona, A; Becht, K; Kim, ND; McKeown, MR; Roberts, JM; Zhang, J; Sim, T; Alessi, DR; Bradner, JE; Lizcano, JM; Blacklow, SC; Qi, J; Xu, X; Gray, NS; 13:2438-2448ACS Chemical Biology10.1021/acschembio.7b0063801.9.2018
30150413BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export.Ngeow, KC; Friedrichsen, HJ; Li, L; Zeng, Z; Andrews, S; Volpon, L; Brunsdon, H; Berridge, G; Picaud, S; Fischer, R; Lisle, R; Knapp, S; Filippakopoulos, P; Knowles, H; Steingrímsson, E; Borden, KLB; Patton, EE; Goding, CR; 115:E8668-E8677Proceedings of the National Academy of Sciences10.1073/pnas.181049811501.9.2018
30143613The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates.Jakobsson ME, Małecki JM, Halabelian L, Nilges BS, Pinto R, Kudithipudi S, Munk S, Davydova E, Zuhairi FR, Arrowsmith CH, Jeltsch A, Leidel SA, Olsen JV, Falnes PØ9(1):3411Nat Commun10.1038/s41467-018-05646-y24.08.2018
30135511Architecture of the native major royal jelly protein 1 oligomer.Tian W, Li M, Guo H, Peng W, Xue X, Hu Y, Liu Y, Zhao Y, Fang X, Wang K, Li X, Tong Y, Conlon MA, Wu W, Ren F, Chen Z9(1):3373Nat Commun10.1038/s41467-018-05619-122.08.2018
Development of 8-pyridopyrimidinone-based covalent inhibitors of KDM5BWright, M; Vazquez-Rodriguez, S; Brennan, P; Kawamura, A; 256:-ACS National Meeting Book of Abstracts19.8.2018
Development of a YEATS-domain chemical probeMoustakim, M; Monteiro, O; Bennett, J; Giroud, C; Christott, T; Saez, L; Panagakou, I; Felce, L; Gamble, V; Huber, K; Farnie, G; Heer, J; Dixon, D; Brennan, P; Federov, O; 256:-ACS National Meeting Book of Abstracts19.8.2018
Development of KDM5 covalent inhibitors as chemical probesVazquez-Rodriguez, S; Wright, M; Brennan, P; 256:-ACS National Meeting Book of Abstracts19.8.2018
30085668Novel Quinazolinone Inhibitors of ALK2 Flip between Alternate Binding Modes: Structure-Activity Relationship, Structural Characterization, Kinase Profiling, and Cellular Proof of Concept.Hudson, L; Mui, J; Vázquez, S; Carvalho, DM; Williams, E; Jones, C; Bullock, AN; Hoelder, S; 61:7261-7272Journal of Medicinal Chemistry10.1021/acs.jmedchem.8b007827.8.2018
30075624Design, Synthesis, and Biological Evaluation of 3-(Imidazo[1,2- a]pyrazin-3-ylethynyl)-4-isopropyl- N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a Dual Inhibitor of Discoidin Domain Receptors 1 and 2.Wang, Z; Zhang, Y; Pinkas, DM; Fox, AE; Luo, J; Huang, H; Cui, S; Xiang, Q; Xu, T; Xun, Q; Zhu, D; Tu, Z; Ren, X; Brekken, RA; Bullock, AN; Liang, G; Ding, K; Lu, X; 61:7977-7990Journal of Medicinal Chemistry10.1021/acs.jmedchem.8b0104501.9.2018
IDENTIFICATION OF SMALL MOLECULES TARGETING THE IL-17 INFLAMMATORY PATHWAY BY LABEL-FREE ASSAYSAlvarez-Coiradas, E; Munteanu, CR; Gomez-Tourino, I; Diaz-Saez, L; Huber, K; Garcia, MIL; Dominguez, E; 123:43-43Basic and Clinical Pharmacology and Toxicology01.8.2018
30050428The Combination of Human Urinary Kallidinogenase and Mild Hypothermia Protects Adult Rats Against Hypoxic-Ischemic Encephalopathy-Induced Injury by Promoting Angiogenesis and Regeneration.Gao X, Xie H, Zhu S, Yu B, Xian Y, Ouyang Q, Ji Y, Yang X, Wen C, Wang P, Tong Y, Wang Q10:196Front Aging Neurosci10.3389/fnagi.2018.0019628.07.2018
SGC-GAK-1: a chemical probe for cyclin G associated kinase (GAK)Asquith, C; Berger, B-T; Wan, J; Bennett, J; East, M; Elkins, J; Fedorov, O; Godoi, P; Hunter, D; Knapp, S; Mueller, S; Wells, C; Earp, S; Willson, T; Zuercher, W; :-10.1101/37677225.7.2018
30031876Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity.Fox, NG; Martelli, A; Nabhan, JF; Janz, J; Borkowska, O; Bulawa, C; Yue, WW; 152:211-218Biochimie10.1016/j.biochi.2018.07.01201.9.2018
30034588LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity.Bonday ZQ, Cortez GS, Grogan MJ, Antonysamy S, Weichert K, Bocchinfuso WP, Li F, Kennedy S, Li B, Mader MM, Arrowsmith CH, Brown PJ, Eram MS, Szewczyk MM, Barsyte-Lovejoy D, Vedadi M, Guccione E, Campbell RM9(7):612-617ACS Med Chem Lett10.1021/acsmedchemlett.8b0001412.07.2018
29992949A TFEB nuclear export signal integrates amino acid supply and glucose availability.Li, L; Friedrichsen, HJ; Andrews, S; Picaud, S; Volpon, L; Ngeow, K; Berridge, G; Fischer, R; Borden, KLB; Filippakopoulos, P; Goding, CR; 9:2685-Nature Communications10.1038/s41467-018-04849-711.7.2018
29983350Anti-Tumour Necrosis Factor Therapy for Dupuytren's Disease: A Randomised Dose Response Proof of Concept Phase 2a Clinical Trial.Nanchahal, J; Ball, C; Davidson, D; Williams, L; Sones, W; McCann, FE; Cabrita, M; Swettenham, J; Cahoon, NJ; Copsey, B; Anne Francis, E; Taylor, PC; Black, J; Barber, VS; Dutton, S; Feldmann, M; Lamb, SE; 33:282-288EBioMedicine10.1016/j.ebiom.2018.06.0226.7.2018
29932332Bench-Stable Transfer Reagent Facilitates the Generation of Trifluoromethyl-sulfonimidamides.Wright, M; Martínez-Lamenca, C; Leenaerts, JE; Brennan, PE; Trabanco, AA; Oehlrich, D; 83:9510-9516Journal of Organic Chemistry10.1021/acs.joc.8b0124401.8.2018
29764755Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases.Bhushan, B; Erdmann, A; Zhang, Y; Belle, R; Johannson, C; Oppermann, U; Hopkinson, RJ; Schofield, CJ; Kawamura, A; 26:2984-2991Bioorganic and Medicinal Chemistry10.1016/j.bmc.2018.03.03001.7.2018
29567296Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2.Moustakim, M; Riedel, K; Schuller, M; Gehring, AP; Monteiro, OP; Martin, SP; Fedorov, O; Heer, J; Dixon, DJ; Elkins, JM; Knapp, S; Bracher, F; Brennan, PE; 26:2965-2972Bioorganic and Medicinal Chemistry10.1016/j.bmc.2018.03.02001.7.2018
29959229Identification of Rpl29 as a major substrate of the lysine methyltransferase Set7/9.Hamidi T, Singh AK, Veland N, Vemulapalli V, Chen J, Hardikar S, Bao J, Fry CJ, Yang V, Lee KA, Guo A, Arrowsmith CH, Bedford MT, Chen TJ. Biol. Chem.10.1074/jbc.RA118.00289029.06.2018
29921600Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities.Casey AE, Sinha A, Singhania R, Livingstone J, Waterhouse P, Tharmapalan P, Cruickshank J, Shehata M, Drysdale E, Fang H, Kim H, Isserlin R, Bailey S, Medina T, Deblois G, Shiah YJ, Barsyte-Lovejoy D, Hofer S, Bader G, Lupien M, Arrowsmith C, Knapp S, De Carvalho D, Berman H, Boutros PC, Kislinger T, Khokha RJ. Cell Biol.10.1083/jcb.20180404219.06.2018
29891918Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition.Froese, DS; Kopec, J; Rembeza, E; Bezerra, GA; Oberholzer, AE; Suormala, T; Lutz, S; Chalk, R; Borkowska, O; Baumgartner, MR; Yue, WW; 9:2261-Nature Communications10.1038/s41467-018-04735-211.6.2018
29880640Structural insight into the human mitochondrial tRNA purine N1-methyltransferase and ribonuclease P complexes.Oerum, S; Roovers, M; Rambo, RP; Kopec, J; Bailey, HJ; Fitzpatrick, F; Newman, JA; Newman, WG; Amberger, A; Zschocke, J; Droogmans, L; Oppermann, U; Yue, WW; 293:12862-12876Journal of Biological Chemistry10.1074/jbc.RA117.00128601.8.2018
29877794An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tetheringKeedy, DA; Hill, ZB; Biel, JT; Kang, E; Rettenmaier, TJ; Brandao-Neto, J; Pearce, NM; von Delft, F; Wells, JA; Fraser, JS; 7:-eLife10.7554/eLife.36307.0017.6.2018
29856130A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition.Favalli N, Biendl S, Hartmann M, Piazzi J, Sladojevich F, Gräslund S, Brown PJ, Näreoja K, Schüler H, Scheuermann J, Franzini R, Neri DChemMedChem10.1002/cmdc.20180019301.06.2018
TNF RECEPTOR 2 PLAYS AN IMMUNOREGULATORY AND ANTI-INFLAMMATORY ROLE IN ARTHRITISTseng, W-Y; Huang, I-S; Clanchy, F; Mcnamee, K; Mccann, F; Williams, RO; 77:250-251Annals of the Rheumatic Diseases10.1136/annrheumdis-2018-eular.605101.6.2018
29847297What Is the BET on Solid Tumors?Filippakopoulos, P;:JCO2018788695-JCO2018788695Journal of Clinical Oncology10.1200/jco.2018.78.869530.5.2018
29794150ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability.Spear, ED; Hsu, E-T; Nie, L; Carpenter, EP; Hrycyna, CA; Michaelis, S; 11:-Disease Models and Mechanisms10.1242/dmm.03367013.7.2018
29789297The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms.Fulcher, LJ; Bozatzi, P; Tachie-Menson, T; Wu, KZL; Cummins, TD; Bufton, JC; Pinkas, DM; Dunbar, K; Shrestha, S; Wood, NT; Weidlich, S; Macartney, TJ; Varghese, J; Gourlay, R; Campbell, DG; Dingwell, KS; Smith, JC; Bullock, AN; Sapkota, GP; 11:-Science Signaling10.1126/scisignal.aao234122.5.2018
29767973Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.Yang, S-M; Martinez, NJ; Yasgar, A; Danchik, C; Johansson, C; Wang, Y; Baljinnyam, B; Wang, AQ; Xu, X; Shah, P; Cheff, D; Wang, XS; Roth, J; Lal-Nag, M; Dunford, JE; Oppermann, U; Vasiliou, V; Simeonov, A; Jadhav, A; Maloney, DJ; 61:4883-4903Journal of Medicinal Chemistry10.1021/acs.jmedchem.8b0027001.6.2018
29765028DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models.Kagoya Y, Nakatsugawa M, Saso K, Guo T, Anczurowski M, Wang CH, Butler MO, Arrowsmith CH, Hirano N9(1):1915Nat Commun10.1038/s41467-018-04262-015.05.2018
29776834BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability.Jennings, LE; Schiedel, M; Hewings, DS; Picaud, S; Laurin, CMC; Bruno, PA; Bluck, JP; Scorah, AR; See, L; Reynolds, JK; Moroglu, M; Mistry, IN; Hicks, A; Guzanov, P; Clayton, J; Evans, CNG; Stazi, G; Biggin, PC; Mapp, AK; Hammond, EM; Humphreys, PG; Filippakopoulos, P; Conway, SJ; 26:2937-2957Bioorganic and Medicinal Chemistry10.1016/j.bmc.2018.05.00301.7.2018
29741882Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors.Ferreira de Freitas R, Harding RJ, Franzoni I, Ravichandran M, Mann MK, Ouyang H, Lautens M, Santhakumar V, Arrowsmith CH, Schapira MJ. Med. Chem.10.1021/acs.jmedchem.8b0025809.05.2018
29723265Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype.Walter, A; Chaikuad, A; Helmer, R; Loaëc, N; Preu, L; Ott, I; Knapp, S; Meijer, L; Kunick, C; 13:e0196761-e0196761PLoS ONE10.1371/journal.pone.01967613.5.2018
29712860The C-terminal extension landscape of naturally presented HLA-I ligands.Guillaume, P; Picaud, S; Baumgaertner, P; Montandon, N; Schmidt, J; Speiser, DE; Coukos, G; Bassani-Sternberg, M; Filippakopoulos, P; Gfeller, D; 115:5083-5088Proceedings of the National Academy of Sciences10.1073/pnas.171727711501.5.2018
29578648Identifying Small-Molecule Binding Sites for Epigenetic Proteins at Domain-Domain Interfaces.Bowkett, D; Talon, R; Tallant, C; Schofield, C; von Delft, F; Knapp, S; Bruton, G; Brennan, PE; 13:1051-1057ChemMedChem10.1002/cmdc.20180003001.5.2018
29712883Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.Horsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, Cader MZ, Carare RO, Davis JB, Duncombe J, Farr TD, Fowler JH, Goense J, Granata A, Hall CN, Hainsworth AH, Harvey A, Hawkes CA, Joutel A, Kalaria RN, Kehoe PG, Lawrence CB, Lockhart A, Love S, Macleod MR, Macrae IM, Markus HS, McCabe C, McColl BW, Meakin PJ, Miller A, Nedergaard M, O'Sullivan M, Quinn TJ, Rajani R, Saksida LM, Smith C, Smith KJ, Touyz RM, Trueman RC, Wang T, Williams A, Williams SCR, Work LM.132(8):851-868Clin Sci (Lond).https://doi.org/10.1042/CS2017162030/04/2018
29676732Donated chemical probes for open science.Müller S, Ackloo S, Arrowsmith CH, Bauser M, Baryza JL, Blagg J, Böttcher J, Bountra C, Brown PJ, Bunnage ME, Carter AJ, Damerell D, Dötsch V, Drewry DH, Edwards AM, Edwards J, Elkins JM, Fischer C, Frye SV, Gollner A, Grimshaw CE, IJzerman A, Hanke T, Hartung IV, Hitchcock S, Howe T, Hughes TV, Laufer S, Li VM, Liras S, Marsden BD, Matsui H, Mathias J, O'Hagan RC, Owen DR, Pande V, Rauh D, Rosenberg SH, Roth BL, Schneider NS, Scholten C, Singh Saikatendu K, Simeonov A, Takizawa M, Tse C, Thompson PR, Treiber DK, Viana AY, Wells CI, Willson TM, Zuercher WJ, Knapp S, Mueller-Fahrnow A7:Elife10.7554/eLife.3431120.04.2018
29642013Discovery of Ubiquitin Deamidases in the Pathogenic Arsenal of Legionella pneumophila.Valleau D, Quaile AT, Cui H, Xu X, Evdokimova E, Chang C, Cuff ME, Urbanus ML, Houliston S, Arrowsmith CH, Ensminger AW, Savchenko A23(2):568-583Cell Rep10.1016/j.celrep.2018.03.06010.04.2018
29632410Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway.Dong C, Zhang H, Li L, Tempel W, Loppnau P, Min JNat. Chem. Biol.10.1038/s41589-018-0036-109.04.2018
29719619TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma.Nakayama K, Szewczyk MM, Dela Sena C, Wu H, Dong A, Zeng H, Li F, de Freitas RF, Eram MS, Schapira M, Baba Y, Kunitomo M, Cary DR, Tawada M, Ohashi A, Imaeda Y, Saikatendu KS, Grimshaw CE, Vedadi M, Arrowsmith CH, Barsyte-Lovejoy D, Kiba A, Tomita D, Brown PJ9(26):18480-18493Oncotarget10.18632/oncotarget.2488306.04.2018
29633446A novel INS mutation in a family with MODY: variable insulin secretion and putative mechanisms.Johnson, SR; McGown, I; Oppermann, U; Conwell, LS; Harris, M; Duncan, EL; :-Pediatric Diabetes10.1111/pedi.126796.4.2018
29633584Virtual fragment screening identification of a novel Quinoline-5,8-dicarboxylic acid derivative as selective JMJD3 inhibitor.Giordano, A; Del Gaudio, F; Johansson, C; Riccio, R; Oppermann, U; Di Micco, S; :-ChemMedChem10.1002/cmdc.2018001986.4.2018
29863194Large-scale analysis of water stability in bromodomain binding pockets with grand canonical Monte Carlo.Aldeghi, M; Ross, GA; Bodkin, MJ; Essex, JW; Knapp, S; Biggin, PC; 1:-Commun Chem10.1038/s42004-018-0019-x01.4.2018
29617648A Pseudo-Kinase Double Act.Preuß, F; Mathea, S; Knapp, S; 26:527-528Structure10.1016/j.str.2018.03.00801.4.2018
Epigenetic Compound Screening Reveals New Therapeutic Targets for ChordomaCottone, L; Hookway, ES; Wells, G; Ligammari, L; Lombard, P; Oppermann, U; Flanagan, AM; 245:S18-S18Journal of Pathology01.4.2018
BROMODOMAIN INHIBITORS ARE POTENT EPIGENETIC REGULATORS OF CATABOLIC GENE EXPRESSION IN HUMAN OSTEOARTHRITIC CHONDROCYTESde Andres, MC; Madhusudan, N; Bountra, C; Oppermann, U; Oreffo, RO; 26:S154-S154Osteoarthritis and Cartilage01.4.2018
Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific InhibitorsSantiago, ADS; Couñago, R; Zonzini Ramos, P; Godoi, PHC; Massirer, KB; Gileadi, O; Elkins, J; :-10.1101/29279731.3.2018
29601130Halogen-Aromatic π Interactions Modulate Inhibitor Residence Times.Heroven, C; Georgi, V; Ganotra, GK; Brennan, P; Wolfreys, F; Wade, RC; Fernández-Montalván, AE; Chaikuad, A; Knapp, S; 57:7220-7224Angewandte Chemie International Edition10.1002/anie.20180166601.6.2018
29567833Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.Liu K, Xu C, Lei M, Yang A, Loppnau P, Hughes TR, Min JJ. Biol. Chem.10.1074/jbc.RA118.00178522.03.2018
29563185Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis.Zhang H, Zhou B, Qin S, Xu J, Harding R, Tempel W, Nayak V, Li Y, Loppnau P, Dou Y, Min JGenes Dev.10.1101/gad.311639.11821.03.2018
29558110Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID Subunit 1.Suh, JL; Watts, B; Stuckey, JI; Norris-Drouin, JL; Cholensky, SH; Dickson, BM; An, Y; Mathea, S; Salah, E; Knapp, S; Khan, A; Adams, AT; Strahl, BD; Sagum, CA; Bedford, MT; James, LI; Kireev, DB; Frye, SV; 57:2140-2149Biochemistry10.1021/acs.biochem.8b0015001.4.2018
Diamond, XChem and CCP-CompMedChem: Creating user-focused tools and workflows for structure-based drug designBradley, A; Skyner, R; von Delft, F; 255:-ACS National Meeting Book of Abstracts18.3.2018
29545596New opportunities for kinase drug repurposing and target discovery.Knapp, S;118:936-937British Journal of Cancer10.1038/s41416-018-0045-616.3.2018
29551750Effects of FKBP12 and type II BMP receptors on signal transduction by ALK2 activating mutations associated with genetic disorders.Machiya, A; Tsukamoto, S; Ohte, S; Kuratani, M; Fujimoto, M; Kumagai, K; Osawa, K; Suda, N; Bullock, AN; Katagiri, T; :-BONE10.1016/j.bone.2018.03.01515.3.2018
29523821p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage.Borisova ME, Voigt A, Tollenaere MAX, Sahu SK, Juretschke T, Kreim N, Mailand N, Choudhary C, Bekker-Jensen S, Akutsu M, Wagner SA, Beli P.9(1):1017Nat Commun10.1038/s41467-018-03417-309.03.2018
29485874Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design.Rahm, F; Viklund, J; Trésaugues, L; Ellermann, M; Giese, A; Ericsson, U; Forsblom, R; Ginman, T; Günther, J; Hallberg, K; Lindström, J; Persson, LB; Silvander, C; Talagas, A; Díaz-Sáez, L; Fedorov, O; Huber, KVM; Panagakou, I; Siejka, P; Gorjánácz, M; Bauser, M; Andersson, M; 61:2533-2551Journal of Medicinal Chemistry10.1021/acs.jmedchem.7b018847.3.2018
29562800Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain.Senisterra G, Zhu HY, Luo X, Zhang H, Xun G, Lu C, Xiao W, Hajian T, Loppnau P, Chau I, Li F, Allali-Hassani A, Atadja P, Oyang C, Li E, Brown PJ, Arrowsmith CH, Zhao K, Yu Z, Vedadi M2472555218766278SLAS Discov10.1177/247255521876627801.03.2018
Oxidative Stress in Endometriosis Induces IL-8 Release Directly via 4-HNE.Elger, BJ; Mueller, J; Morton, KJ; Kessler, B; Becker, CM; Steers, G; Thezenas, ML; Zondervan, KT; Zollner, TM; Oppermann, U; 25:219A-219AReproductive Sciences01.3.2018
Quantitative Characterization by Mass Cytometry Reveals a Complex Immune Environment and Activation Pattern in the Peritoneal Fluid of Endometriosis PatientsGuo, M; Bafligil, C; Tapmeier, TT; Hubbard, C; Dale, M; Manek, S; Shang, C; Obendorf, M; Sacher, F; Fischer, OM; Hess-Stumpp, H; Zollner, T; Kennedy, S; Becker, CM; Zondervan, KT; Soderstrom, K; Oppermann, U; 25:147A-147AReproductive Sciences01.3.2018
Proteomic and Transcriptomic Analysis of Oxidative Stress, Lipid Peroxidation and Iron Uptake Signatures in Endometriotic Lesions.Elger, B; Thezenas, ML; Becker, CM; Zondervan, KT; Morton, KJ; Zollner, TM; Kessler, BM; Oppermann, U; 25:289A-290AReproductive Sciences01.3.2018
29494751Structural and histone binding studies of the chromo barrel domain of TIP60.Zhang Y, Lei M, Yang X, Feng Y, Yang Y, Loppnau P, Li Y, Yang Y, Min J, Liu YFEBS Lett.10.1002/1873-3468.1302101.03.2018
29483652Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63.Tuppi, M; Kehrloesser, S; Coutandin, DW; Rossi, V; Luh, LM; Strubel, A; Hötte, K; Hoffmeister, M; Schäfer, B; De Oliveira, T; Greten, F; Stelzer, EHK; Knapp, S; De Felici, M; Behrends, C; Klinger, FG; Dötsch, V; 25:261-269Nature Structural and Molecular Biology10.1038/s41594-018-0035-726.2.2018
29655609Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases.Zhang, D; Markoulides, MS; Stepanovs, D; Rydzik, AM; El-Hussein, A; Bon, C; Kamps, JJAG; Umland, K-D; Collins, PM; Cahill, ST; Wang, DY; von Delft, F; Brem, J; McDonough, MA; Schofield, CJ; 26:2928-2936Bioorganic and Medicinal Chemistry10.1016/j.bmc.2018.02.04301.7.2018
29436819Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry.Vu H, Pedro L, Mak T, McCormick B, Rowley J, Liu M, Di Capua A, Williams-Noonan B, Pham NB, Pouwer RH, Nguyen B, Andrews KT, Skinner-Adams T, Kim J, Hol WGJ, Hui R, Crowther GJ, Van Voorhis WC, Quinn RJACS Infect Dis10.1021/acsinfecdis.7b0019713.02.2018
29449935Pleomorphic liposarcoma of bone: a rare primary malignant bone tumour.Tiemeier, GL; Brown, JM; Pratap, SE; McCarthy, C; Kastrenopoulou, A; Bradley, K; Wilson, S; Orosz, Z; Gibbons, CLMH; Oppermann, U; Athanasou, NA; 8:2-Clinical Sarcoma Research10.1186/s13569-018-0089-701.1.2018
A PIP2 Binding Site on a Human TRP Channel: Simulation Studies of PKD2Wang, Q; Hedger, G; Aryal, P; Shi, J; Carpenter, EP; Sansom, MSP; 114:397A-397ABiophysical Journal2.2.2018
29396402Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation.Zheng, Y; Sethi, R; Mangala, LS; Taylor, C; Goldsmith, J; Wang, M; Masuda, K; Karaminejadranjbar, M; Mannion, D; Miranda, F; Herrero-Gonzalez, S; Hellner, K; Chen, F; Alsaadi, A; Albukhari, A; Fotso, DC; Yau, C; Jiang, D; Pradeep, S; Rodriguez-Aguayo, C; Lopez-Berestein, G; Knapp, S; Gray, NS; Campo, L; Myers, KA; Dhar, S; Ferguson, D; Bast, RC; Sood, AK; von Delft, F; Ahmed, AA; 9:476-Nature Communications10.1038/s41467-017-02811-72.2.2018
29409752Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors.Suebsuwong, C; Pinkas, DM; Ray, SS; Bufton, JC; Dai, B; Bullock, AN; Degterev, A; Cuny, GD; 28:577-583Bioorganic and Medicinal Chemistry Letters10.1016/j.bmcl.2018.01.04401.2.2018
29533241Where is crystallography going?Grimes, JM; Hall, DR; Ashton, AW; Evans, G; Owen, RL; Wagner, A; McAuley, KE; von Delft, F; Orville, AM; Sorensen, T; Walsh, MA; Ginn, HM; Stuart, DI; 74:152-166Acta Crystallographica. Section d, Structural Biology10.1107/S205979831701670901.2.2018
29533233CCP4i2: the new graphical user interface to the CCP4 program suite.Potterton, L; Agirre, J; Ballard, C; Cowtan, K; Dodson, E; Evans, PR; Jenkins, HT; Keegan, R; Krissinel, E; Stevenson, K; Lebedev, A; McNicholas, SJ; Nicholls, RA; Noble, M; Pannu, NS; Roth, C; Sheldrick, G; Skubak, P; Turkenburg, J; Uski, V; von Delft, F; Waterman, D; Wilson, K; Winn, M; Wojdyr, M; 74:68-84Acta Crystallographica. Section d, Structural Biology10.1107/S205979831701603501.2.2018
29564125Therapeutics discovery: From bench to first in-human trials.Al-Hujaily, EM; Khatlani, T; Alehaideb, Z; Ali, R; Almuzaini, B; Alrfaei, BM; Iqbal, J; Islam, I; Malik, S; Marwani, BA; Massadeh, S; Nehdi, A; Alsomaie, B; Debasi, B; Bushnak, I; Noibi, S; Hussain, S; Wajid, WA; Armand, J-P; Gul, S; Oyarzabal, J; Rais, R; Bountra, C; Alaskar, A; Knawy, BA; Boudjelal, M; 8:275-282Biomedical Reports10.3892/br.2018.105201.3.2018
29373579An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells.Schrade, K; Tröger, J; Eldahshan, A; Zühlke, K; Abdul Azeez, KR; Elkins, JM; Neuenschwander, M; Oder, A; Elkewedi, M; Jaksch, S; Andrae, K; Li, J; Fernandes, J; Müller, PM; Grunwald, S; Marino, SF; Vukićević, T; Eichhorst, J; Wiesner, B; Weber, M; Kapiloff, M; Rocks, O; Daumke, O; Wieland, T; Knapp, S; von Kries, JP; Klussmann, E; 13:e0191423-PLoS ONE10.1371/journal.pone.019142326.1.2018
29320176Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT).Babault N, Allali-Hassani A, Li F, Fan J, Yue A, Ju K, Liu F, Vedadi M, Liu J, Jin JJ. Med. Chem.10.1021/acs.jmedchem.7b0142210.01.2018
29321206Revealing the Protein Propionylation Activity of the Histone Acetyltransferase Males absent on the first (MOF).Han Z, Wu H, Kim S, Yang X, Li Q, Huang H, Cai H, Bartlett MG, Dong A, Zeng H, Brown PJ, Yang X, Arrowsmith CH, Zhao Y, Zheng YGJ. Biol. Chem.10.1074/jbc.RA117.00052910.01.2018
29300400Mild, calcium catalysed Beckmann rearrangements.Kiely-Collins, HJ; Sechi, I; Brennan, PE; McLaughlin, MG; 54:654-657Chemical Communications10.1039/c7cc09491d01.1.2018
29301935Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells.Cribbs, A; Hookway, ES; Wells, G; Lindow, M; Obad, S; Oerum, H; Prinjha, RK; Athanasou, N; Sowman, A; Philpott, M; Penn, H; Soderstrom, K; Feldmann, M; Oppermann, U; 293:2422-2437Journal of Biological Chemistry10.1074/jbc.ra117.00069801.2.2018
30202513Periostin expression in neoplastic and non-neoplastic diseases of bone and joint.Brown, JM; Mantoku, A; Sabokbar, A; Oppermann, U; Hassan, AB; Kudo, A; Athanasou, N; 8:18-Clinical Sarcoma Research10.1186/s13569-018-0105-y01.1.2018
Prostacyclin: a potential novel therapeutic target to treat tendon pain and inflammationBergqvist, F; Carr, AJ; Wheway, K; Watkins, B; Oppermann, U; Jakobsson, P; Dakin, SG; 47:17-18Scandinavian Journal of Rheumatology01.01.2018
29191367Heterotypic Ubiquitin Chains: Seeing is Believing.Stolz A, Dikic I.28(1):1-3Trends Cell Biol10.1016/j.tcb.2017.11.00501.01.2018
30390801Achieving a Good Crystal System for Crystallographic X-Ray Fragment Screening.Collins, PM; Douangamath, A; Talon, R; Dias, A; Brandao-Neto, J; Krojer, T; von Delft, F; 610:251-264Methods in Enzymology10.1016/bs.mie.2018.09.02701.1.2018
TNFR signalling and its clinical implicationsTseng, W-Y; Huang, Y-S; Lin, H-H; Luo, S-F; McCann, F; McNamee, K; Clanchy, F; Williams, R; 101:19-25Cytokine10.1016/j.cyto.2016.08.02701.1.2018
30390803Target Identification Using Chemical Probes.Moustakim, M; Felce, SL; Zaarour, N; Farnie, G; McCann, FE; Brennan, PE; 610:27-58Methods in Enzymology10.1016/bs.mie.2018.09.01301.1.2018
29291391Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment.Bulbrook, D; Brazier, H; Mahajan, P; Kliszczak, M; Fedorov, O; Marchese, FP; Aubareda, A; Chalk, R; Picaud, S; Strain-Damerell, C; Filippakopoulos, P; Gileadi, O; Clark, AR; Yue, WW; Burgess-Brown, NA; Dean, JLE; 430:722-736Journal of Molecular Biology10.1016/j.jmb.2017.12.01801.3.2018
29256564Correction: Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety.Sansook, S; Ocasio, CA; Day, IJ; Tizzard, GJ; Coles, SJ; Fedorov, O; Bennett, JM; Elkins, JM; Spencer, J; 16:336-Organic and Biomolecular Chemistry10.1039/c7ob90195j01.1.2018
29237730An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein.Delbart, F; Brams, M; Gruss, F; Noppen, S; Peigneur, S; Boland, S; Chaltin, P; Brandao-Neto, J; von Delft, F; Touw, WG; Joosten, RP; Liekens, S; Tytgat, J; Ulens, C; 293:2534-2545Journal of Biological Chemistry10.1074/jbc.M117.81531601.2.2018
29187380Nbeal2 interacts with Dock7, Sec16a, and Vac14.Mayer, L; Jasztal, M; Pardo, M; Aguera de Haro, S; Collins, J; Bariana, TK; Smethurst, PA; Grassi, L; Petersen, R; Nurden, P; Favier, R; Yu, L; Meacham, S; Astle, WJ; Choudhary, J; Yue, WW; Ouwehand, WH; Guerrero, JA; 131:1000-1011Blood10.1182/blood-2017-08-80035901.3.2018
29174542Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement.Vasta, JD; Corona, CR; Wilkinson, J; Zimprich, CA; Hartnett, JR; Ingold, MR; Zimmerman, K; Machleidt, T; Kirkland, TA; Huwiler, KG; Ohana, RF; Slater, M; Otto, P; Cong, M; Wells, CI; Berger, B-T; Hanke, T; Glas, C; Ding, K; Drewry, DH; Huber, KVM; Willson, TM; Knapp, S; Müller, S; Meisenheimer, PL; Fan, F; Wood, KV; Robers, MB; 25:206-214.e11Cell Chemical Biology10.1016/j.chembiol.2017.10.01001.2.2018
29072804Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase.Asquith, CRM; Laitinen, T; Bennett, JM; Godoi, PH; East, MP; Tizzard, GJ; Graves, LM; Johnson, GL; Dornsife, RE; Wells, CI; Elkins, JM; Willson, TM; Zuercher, WJ; 13:48-66ChemMedChem10.1002/cmdc.20170066301.1.2018
28994500The Cysteinome of Protein Kinases as a Target in Drug Development.Chaikuad, A; Koch, P; Laufer, SA; Knapp, S; 57:4372-4385Angewandte Chemie International Edition10.1002/anie.20170787501.4.2018
28918311Structural basis for the potent and selective binding of LDN-212854 to the BMP receptor kinase ALK2.Williams, E; Bullock, AN; 109:251-258BONE10.1016/j.bone.2017.09.00401.4.2018
28936339Utility of VS38c in the diagnostic and prognostic assessment of osteosarcoma and other bone tumours/tumour-like lesions.Hookway, ES; Orosz, Z; Uchihara, Y; Grigoriadis, A; Hassan, AB; Oppermann, U; Athanasou, NA; 7:17-Clinical Sarcoma Research10.1186/s13569-017-0083-501.1.2017
TGM2 Is Highly Expressed and Active in Endometriosis Where It Mediates Pro-Fibrotic and Pro-Inflammatory Effects.Estrada, FM; Obendorf, M; Mesch, S; Fischer, OM; Bafligil, C; Guo, M; Becker, C; Zondervan, K; Shang, C; Kennedy, S; Gordon, S; Zollner, TM; Oppermann, U; 24:141A-142AReproductive Sciences01.3.2017
29276034DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.Xu C, Liu K, Lei M, Yang A, Li Y, Hughes TR, Min JStructure10.1016/j.str.2017.11.02216.12.2017
29244490Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3).Kaniskan HÜ, Eram MS, Zhao K, Szewczyk MM, Yang X, Schmidt K, Luo X, Xiao S, Dai M, He F, Zang I, Lin Y, Li F, Dobrovetsky E, Smil D, Min SJ, Lin-Jones J, Schapira M, Atadja P, Li E, Barsyte-Lovejoy D, Arrowsmith CH, Brown PJ, Liu F, Yu Z, Vedadi M, Jin JJ. Med. Chem.10.1021/acs.jmedchem.7b0167415.12.2017
29234025H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.Jurkowska RZ, Qin S, Kungulovski G, Tempel W, Liu Y, Bashtrykov P, Stiefelmaier J, Jurkowski TP, Kudithipudi S, Weirich S, Tamas R, Wu H, Dombrovski L, Loppnau P, Reinhardt R, Min J, Jeltsch A8(1):2057Nat Commun10.1038/s41467-017-02259-912.12.2017
Targeting IL-1 beta-Wnt signalling to prevent breast cancer colonisation in the bone microenvironmentEyre, R; Alferez, D; Santiago-Gomez, A; Spence, K; McConnell, J; Simoes, B; Hart, C; Lefley, D; Tulotta, C; Gurney, A; Howell, S; Brown, M; Sims, A; Farnie, G; Ottewell, P; Clarke, R; 34:493-493Clinical and Experimental Metastasis01.12.2017
29262329PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression.Chiang, K; Zielinska, AE; Shaaban, AM; Sanchez-Bailon, MP; Jarrold, J; Clarke, TL; Zhang, J; Francis, A; Jones, LJ; Smith, S; Barbash, O; Guccione, E; Farnie, G; Smalley, MJ; Davies, CC; 21:3498-3513Cell Reports10.1016/j.celrep.2017.11.09601.12.2017
29186216Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition.Belle, R; Al Temimi, AHK; Kumar, K; Pieters, BJGE; Tumber, A; Dunford, JE; Johansson, C; Oppermann, U; Brown, T; Schofield, CJ; Hopkinson, RJ; Paton, RS; Kawamura, A; Mecinović, J; 53:13264-13267Chemical Communications10.1039/c7cc08028j01.12.2017
29094929Structural Basis for the Serratia marcescens Lipase Secretion System: Crystal Structures of the Membrane Fusion Protein and Nucleotide-Binding Domain.Murata D, Okano H, Angkawidjaja C, Akutsu M, Tanaka SI, Kitahara K, Yoshizawa T, Matsumura H, Kado Y, Mizohata E, Inoue T, Sano S, Koga Y, Kanaya S, Takano K.56(47):6281-6291Biochemistry10.1021/acs.biochem.7b0098528.11.2017
29167426Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival.Segatto, M; Fittipaldi, R; Pin, F; Sartori, R; Dae Ko, K; Zare, H; Fenizia, C; Zanchettin, G; Pierobon, ES; Hatakeyama, S; Sperti, C; Merigliano, S; Sandri, M; Filippakopoulos, P; Costelli, P; Sartorelli, V; Caretti, G; 8:1707-1707Nature Communications10.1038/s41467-017-01645-722.11.2017
29043777Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action.Fernández-Montalván, AE; Berger, M; Kuropka, B; Koo, SJ; Badock, V; Weiske, J; Puetter, V; Holton, SJ; Stöckigt, D; Ter Laak, A; Centrella, PA; Clark, MA; Dumelin, CE; Sigel, EA; Soutter, HH; Troast, DM; Zhang, Y; Cuozzo, JW; Keefe, AD; Roche, D; Rodeschini, V; Chaikuad, A; Díaz-Sáez, L; Bennett, JM; Fedorov, O; Huber, KVM; Hübner, J; Weinmann, H; Hartung, IV; Gorjánácz, M; 12:2730-2736ACS Chemical Biology10.1021/acschembio.7b0070801.11.2017
29150600Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers.Zuliani-Alvarez, L; Marzeda, AM; Deligne, C; Schwenzer, A; McCann, FE; Marsden, BD; Piccinini, AM; Midwood, KS; 8:1595-Nature Communications10.1038/s41467-017-01718-717.11.2017
29142305Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors.Dahlin JL, Nelson KM, Strasser JM, Barsyte-Lovejoy D, Szewczyk MM, Organ S, Cuellar M, Singh G, Shrimp JH, Nguyen N, Meier JL, Arrowsmith CH, Brown PJ, Baell JB, Walters MA8(1):1527Nat Commun10.1038/s41467-017-01657-315.11.2017
29118143Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2.Zhang H, Liu K, Izumi N, Huang H, Ding D, Ni Z, Sidhu SS, Chen C, Tomari Y, Min JProc. Natl. Acad. Sci. U.S.A.10.1073/pnas.171148611408.11.2017
29118096The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery.Bradley, AR; Echalier, A; Fairhead, M; Strain-Damerell, C; Brennan, P; Bullock, AN; Burgess-Brown, NA; Carpenter, EP; Gileadi, O; Marsden, BD; Lee, WH; Yue, W; Bountra, C; von Delft, F; 61:495-503Essays in Biochemistry10.1042/EBC201700518.11.2017
Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7Gerken, PA; Wolstenhulme, JR; Tumber, A; Hatch, SB; Zhang, Y; Müller, S; Chandler, SA; Mair, B; Li, F; Nijman, SMB; Konietzny, R; Szommer, T; Yapp, C; Fedorov, O; Benesch, JLP; Vedadi, M; Kessler, BM; Kawamura, A; Brennan, PE; Smith, MD; 129:15761-15765Angewandte Chemie International Edition10.1002/ange.2017067884.12.2017
29108111Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile.Hanson, AL; Cuddihy, T; Haynes, K; Loo, D; Morton, CJ; Oppermann, U; Leo, P; Thomas, GP; Lê Cao, K-A; Kenna, TJ; Brown, MA; 70:255-265Arthritis and Rheumatology10.1002/art.403696.11.2017
29170024Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.Shadrick, WR; Slavish, PJ; Chai, SC; Waddell, B; Connelly, M; Low, JA; Tallant, C; Young, BM; Bharatham, N; Knapp, S; Boyd, VA; Morfouace, M; Roussel, MF; Chen, T; Lee, RE; Kiplin Guy, R; Shelat, AA; Potter, PM; 26:25-36Bioorganic and Medicinal Chemistry10.1016/j.bmc.2017.10.0424.11.2017
29101300Pharmacoproteomic characterisation of human colon and rectal cancer.Frejno, M; Zenezini Chiozzi, R; Wilhelm, M; Koch, H; Zheng, R; Klaeger, S; Ruprecht, B; Meng, C; Kramer, K; Jarzab, A; Heinzlmeir, S; Johnstone, E; Domingo, E; Kerr, D; Jesinghaus, M; Slotta-Huspenina, J; Weichert, W; Knapp, S; Feller, SM; Kuster, B; 13:951-Molecular Systems Biology10.15252/msb.201777013.11.2017
28991428Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14.Schuller, M; Riedel, K; Gibbs-Seymour, I; Uth, K; Sieg, C; Gehring, AP; Ahel, I; Bracher, F; Kessler, BM; Elkins, JM; Knapp, S; 12:2866-2874ACS Chemical Biology10.1021/acschembio.7b0044501.11.2017
28757617Nilotinib-induced vasculopathy: identification of vascular endothelial cells as a primary target site.Hadzijusufovic, E; Albrecht-Schgoer, K; Huber, K; Hoermann, G; Grebien, F; Eisenwort, G; Schgoer, W; Herndlhofer, S; Kaun, C; Theurl, M; Sperr, WR; Rix, U; Sadovnik, I; Jilma, B; Schernthaner, GH; Wojta, J; Wolf, D; Superti-Furga, G; Kirchmair, R; Valent, P; 31:2388-2397Leukemia10.1038/leu.2017.24501.11.2017
28752568IDUA mutational profile and genotype-phenotype relationships in UK patients with Mucopolysaccharidosis Type I.Ghosh, A; Mercer, J; Mackinnon, S; Yue, WW; Church, H; Beesley, CE; Broomfield, A; Jones, SA; Tylee, K; 38:1555-1568Human Mutation10.1002/humu.2330101.11.2017
28963344Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.Pinkas, DM; Sanvitale, CE; Bufton, JC; Sorrell, FJ; Solcan, N; Chalk, R; Doutch, J; Bullock, AN; 474:3747-3761Biochemical Journal10.1042/BCJ2017052701.11.2017
29074623Conformational dynamics of the TTD-PHD histone reader module of UHRF1 reveals multiple histone binding states, allosteric regulation and druggability.Houliston RS, Lemak A, Iqbal A, Ivanochko D, Duan S, Kaustov L, Ong MS, Fan L, Senisterra G, Brown PJ, Wang YX, Arrowsmith CHJ. Biol. Chem.10.1074/jbc.M117.79970026.10.2017
28984325Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety.Sansook, S; Ocasio, CA; Day, IJ; Tizzard, GJ; Coles, SJ; Fedorov, O; Bennett, JM; Elkins, JM; Spencer, J; 15:8655-8660Organic and Biomolecular Chemistry10.1039/c7ob02289a01.10.2017
29045126Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.McIntyre, PJ; Collins, PM; Vrzal, L; Birchall, K; Arnold, LH; Mpamhanga, C; Coombs, PJ; Burgess, SG; Richards, MW; Winter, A; Veverka, V; Delft, FV; Merritt, A; Bayliss, R; 12:2906-2914ACS Chemical Biology10.1021/acschembio.7b0053701.11.2017
29026209WD40 repeat domain proteins: a novel target class?Schapira M, Tyers M, Torrent M, Arrowsmith CHNat Rev Drug Discov10.1038/nrd.2017.17913.10.2017
29019676Small molecule antagonists of the interaction between the histone deacetylase 6 zinc-finger domain and ubiquitin.Harding RJ, Ferreira de Freitas R, Collins PM, Franzoni I, Ravichandran M, Ouyang H, Juarez-Ornelas KA, Lautens M, Schapira M, von Delft F, Santhakumar V, Arrowsmith CHJ. Med. Chem.10.1021/acs.jmedchem.7b0093311.10.2017
29017057A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer.Mello SS, Valente LJ, Raj N, Seoane JA, Flowers BM, McClendon J, Bieging-Rolett KT, Lee J, Ivanochko D, Kozak MM, Chang DT, Longacre TA, Koong AC, Arrowsmith CH, Kim SK, Vogel H, Wood LD, Hruban RH, Curtis C, Attardi LD32(4):460-473.e6Cancer Cell10.1016/j.ccell.2017.09.00709.10.2017
28983993Synthesis and Demonstration of the Biological Relevance of sp3 -rich Scaffolds Distantly Related to Natural Product Frameworks.Foley, DJ; Craven, PGE; Collins, PM; Doveston, RG; Aimon, A; Talon, R; Churcher, I; von Delft, F; Marsden, SP; Nelson, A; 23:15227-15232Chemistry - A European Journal10.1002/chem.2017041696.10.2017
28976073Discovery of a highly selective cell-active inhibitor of KDM2/7.Gerken P, Wolstenhulme J, Tumber A, Hatch S, Zhang Y, Müller S, Chandler S, Mair B, Li F, Nijman S, Konietzny R, Szommer T, Yapp C, Fedorov O, Benesch J, Vedadi M, Kessler B, Kawamura A, Brennan P, Smith MDAngew. Chem. Int. Ed. Engl.10.1002/anie.20170678804.10.2017
28976073Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7.Gerken, PA; Wolstenhulme, JR; Tumber, A; Hatch, SB; Zhang, Y; Müller, S; Chandler, SA; Mair, B; Li, F; Nijman, SMB; Konietzny, R; Szommer, T; Yapp, C; Fedorov, O; Benesch, JLP; Vedadi, M; Kessler, BM; Kawamura, A; Brennan, PE; Smith, MD; 56:15555-15559Angewandte Chemie International Edition10.1002/anie.20170678801.12.2017
29308120A systematic analysis of atomic protein-ligand interactions in the PDB.Ferreira de Freitas R, Schapira M8(10):1970-1981Medchemcomm10.1039/c7md00381a01.10.2017
28923939Asymmetric mechanosensitivity in a eukaryotic ion channel.Clausen, MV; Jarerattanachat, V; Carpenter, EP; Sansom, MSP; Tucker, SJ; 114:E8343-E8351Proceedings of the National Academy of Sciences10.1073/pnas.170899011401.10.2017
28899999Correction for Bagarova et al., "Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation".Bagarova, J; Vonner, AJ; Armstrong, KA; Börgermann, J; Lai, CSC; Deng, DY; Beppu, H; Alfano, I; Filippakopoulos, P; Morrell, NW; Bullock, AN; Knaus, P; Mishina, Y; Yu, PB; 37:-Molecular and Cellular Biology10.1128/mcb.00284-1701.10.2017
28956604Disease Association and Druggability of WD40 Repeat Proteins.Song R, Wang ZD, Schapira MJ. Proteome Res.10.1021/acs.jproteome.7b0045128.09.2017
28962858Crystal structure of the WD40 domain of human PRPF19.Zhang Y, Li Y, Liang X, Zhu Z, Sun H, He H, Min J, Liao S, Liu YBiochem. Biophys. Res. Commun.10.1016/j.bbrc.2017.09.14526.09.2017
28933846Inhibition of calcium dependent protein kinase 1 (CDPK1) by pyrazolopyrimidine analogs decreases establishment and reoccurrence of central nervous system disease by Toxoplasma gondii.Rutaganira FU, Barks J, Dhason MS, Wang Q, Lopez MS, Long S, Radke JB, Jones NG, Maddirala AR, Janetka JW, El Bakkouri M, Hui R, Shokat KM, Sibley LDJ. Med. Chem.10.1021/acs.jmedchem.7b0119221.09.2017
28887458Increased 15-PGDH expression leads to dysregulated resolution responses in stromal cells from patients with chronic tendinopathy.Dakin, SG; Ly, L; Colas, RA; Oppermann, U; Wheway, K; Watkins, B; Dalli, J; Carr, AJ; 7:11009-Scientific Reports10.1038/s41598-017-11188-y8.9.2017
28886345RAC1 Missense Mutations in Developmental Disorders with Diverse Phenotypes.Reijnders, MRF; Ansor, NM; Kousi, M; Yue, WW; Tan, PL; Clarkson, K; Clayton-Smith, J; Corning, K; Jones, JR; Lam, WWK; Mancini, GMS; Marcelis, C; Mohammed, S; Pfundt, R; Roifman, M; Cohn, R; Chitayat, D; Deciphering Developmental Disorders Study, ; Millard, TH; Katsanis, N; Brunner, HG; Banka, S; 101:466-477American Journal of Human Genetics10.1016/j.ajhg.2017.08.00701.9.2017
28888424Novel patient missense mutations in the HSD17B10 gene affect dehydrogenase and mitochondrial tRNA modification functions of the encoded protein.Oerum, S; Roovers, M; Leichsenring, M; Acquaviva-Bourdain, C; Beermann, F; Gemperle-Britschgi, C; Fouilhoux, A; Korwitz-Reichelt, A; Bailey, HJ; Droogmans, L; Oppermann, U; Sass, JO; Yue, WW; 1863:3294-3302BBA - Molecular Basis of Disease10.1016/j.bbadis.2017.09.00201.12.2017
28874661A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.Baker DA, Stewart LB, Large JM, Bowyer PW, Ansell KH, Jiménez-Díaz MB, El Bakkouri M, Birchall K, Dechering KJ, Bouloc NS, Coombs PJ, Whalley D, Harding DJ, Smiljanic-Hurley E, Wheldon MC, Walker EM, Dessens JT, Lafuente MJ, Sanz LM, Gamo FJ, Ferrer SB, Hui R, Bousema T, Angulo-Barturén I, Merritt AT, Croft SL, Gutteridge WE, Kettleborough CA, Osborne SA8(1):430Nat Commun10.1038/s41467-017-00572-x05.09.2017
28864533First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor.Moody JD, Levy S, Mathieu J, Xing Y, Kim W, Dong C, Tempel W, Robitaille AM, Dang LT, Ferreccio A, Detraux D, Sidhu S, Zhu L, Carter L, Xu C, Valensisi C, Wang Y, Hawkins RD, Min J, Moon RT, Orkin SH, Baker D, Ruohola-Baker HProc. Natl. Acad. Sci. U.S.A.10.1073/pnas.170690711401.09.2017
28827282A novel image-based high-throughput screening assay discovers therapeutic candidates for adult polyglucosan body disease.Solmesky, LJ; Khazanov, N; Senderowitz, H; Wang, P; Minassian, BA; Ferreira, IM; Yue, WW; Lossos, A; Weil, M; Kakhlon, O; 474:3403-3420Biochemical Journal10.1042/BCJ2017046928.9.2017
28827149Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates.Tarhonskaya, H; Nowak, RP; Johansson, C; Szykowska, A; Tumber, A; Hancock, RL; Lang, P; Flashman, E; Oppermann, U; Schofield, CJ; Kawamura, A; 429:2895-2906Journal of Molecular Biology10.1016/j.jmb.2017.08.00701.9.2017
28786670Statistical Analysis on the Performance of Molecular Mechanics Poisson-Boltzmann Surface Area versus Absolute Binding Free Energy Calculations: Bromodomains as a Case Study.Aldeghi, M; Bodkin, MJ; Knapp, S; Biggin, PC; 57:2203-2221Journal of Chemical Information and Modeling10.1021/acs.jcim.7b0034701.9.2017
Regulation of Two-pore Domain K plus Channels by Natural Effectors and Pharmacological AgentsSchewe, M; Schulz, F; Mert, U; Sun, H; Belabed, H; Musinszki, M; Koehler, T; Tegtmeier, M; Nazare, M; Carpenter, EP; Tucker, SJ; Baukrowitz, T; :-Acta Physiologica01.9.2017
28854171Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy.Lan X, Jörg DJ, Cavalli FMG, Richards LM, Nguyen LV, Vanner RJ, Guilhamon P, Lee L, Kushida MM, Pellacani D, Park NI, Coutinho FJ, Whetstone H, Selvadurai HJ, Che C, Luu B, Carles A, Moksa M, Rastegar N, Head R, Dolma S, Prinos P, Cusimano MD, Das S, Bernstein M, Arrowsmith CH, Mungall AJ, Moore RA, Ma Y, Gallo M, Lupien M, Pugh TJ, Taylor MD, Hirst M, Eaves CJ, Simons BD, Dirks PBNature10.1038/nature2366630.08.2017
28855339Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing.Zhang Z, Jones AE, Wu W, Kim J, Kang Y, Bi X, Gu Y, Popov IK, Renfrow MB, Vassylyeva MN, Vassylyev DG, Giles KE, Chen D, Kumar A, Fan Y, Tong Y, Liu CF, An W, Chang C, Luo J, Chow LT, Wang HProc. Natl. Acad. Sci. U.S.A.10.1073/pnas.171115811430.08.2017
28851831TFG facilitates outer coat disassembly on COPII transport carriers to promote tethering and fusion with ER-Golgi intermediate compartments.Hanna MG, Block S, Frankel EB, Hou F, Johnson A, Yuan L, Knight G, Moresco JJ, Yates JR, Ashton R, Schekman R, Tong Y, Audhya AProc. Natl. Acad. Sci. U.S.A.10.1073/pnas.170912011429.08.2017
28849908Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation.Meier, JC; Tallant, C; Fedorov, O; Witwicka, H; Hwang, S-Y; van Stiphout, RG; Lambert, J-P; Rogers, C; Yapp, C; Gerstenberger, BS; Fedele, V; Savitsky, P; Heidenreich, D; Daniels, DL; Owen, DR; Fish, PV; Igoe, NM; Bayle, ED; Haendler, B; Oppermann, UCT; Buffa, F; Brennan, PE; Müller, S; Gingras, AC; Odgren, PR; Birnbaum, MJ; Knapp, S; 12:2619-2630ACS Chemical Biology10.1021/acschembio.7b0048101.10.2017
28890361Comprehensive Analysis of the Human SH3 Domain Family Reveals a Wide Variety of Non-canonical Specificities.Teyra J, Huang H, Jain S, Guan X, Dong A, Liu Y, Tempel W, Min J, Tong Y, Kim PM, Bader GD, Sidhu SSStructure10.1016/j.str.2017.07.01728.08.2017
28841214Tudor-domain protein PHF20L1 reads lysine methylated retinoblastoma tumour suppressor protein.Carr, SM; Munro, S; Sagum, CA; Fedorov, O; Bedford, MT; La Thangue, NB; 24:2139-2149Cell Death and Differentiation10.1038/cdd.2017.13501.12.2017
2876252819 F NMR isotropic chemical shift for efficient screening of fluorinated fragments which are racemates and/or display multiple conformers.Dalvit, C; Knapp, S; 55:1091-1095Magnetic Resonance in Chemistry10.1002/mrc.464001.12.2017
28806989Maximising value from a United Kingdom Biomedical Research Centre: study protocol.Greenhalgh, T; Ovseiko, PV; Fahy, N; Shaw, S; Kerr, P; Rushforth, AD; Channon, KM; Kiparoglou, V; Partnerships for Health, Wealth and Innovation cross-cutting theme of the National Institute for Health Research Biomedical Research Centre, Oxford, ; 15:70-Health Research Policy and Systems10.1186/s12961-017-0237-114.8.2017
28818446Characterization of a highly selective inhibitor of the Aurora kinases.Ferguson, FM; Doctor, ZM; Chaikuad, A; Sim, T; Kim, ND; Knapp, S; Gray, NS; 27:4405-4408Bioorganic and Medicinal Chemistry Letters10.1016/j.bmcl.2017.08.01610.8.2017
28714688Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins.Igoe, N; Bayle, ED; Tallant, C; Fedorov, O; Meier, JC; Savitsky, P; Rogers, C; Morias, Y; Scholze, S; Boyd, H; Cunoosamy, D; Andrews, DM; Cheasty, A; Brennan, PE; Müller, S; Knapp, S; Fish, PV; 60:6998-7011Journal of Medicinal Chemistry10.1021/acs.jmedchem.7b0061110.8.2017
28790404Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.Couñago, RM; Allerston, CK; Savitsky, P; Azevedo, H; Godoi, PH; Wells, CI; Mascarello, A; de Souza Gama, FH; Massirer, KB; Zuercher, WJ; Guimarães, CRW; Gileadi, O; 7:7501-Scientific Reports10.1038/s41598-017-07755-y8.8.2017
28767711Progress towards a public chemogenomic set for protein kinases and a call for contributions.Drewry, DH; Wells, CI; Andrews, DM; Angell, R; Al-Ali, H; Axtman, AD; Capuzzi, SJ; Elkins, JM; Ettmayer, P; Frederiksen, M; Gileadi, O; Gray, N; Hooper, A; Knapp, S; Laufer, S; Luecking, U; Michaelides, M; Müller, S; Muratov, E; Denny, RA; Saikatendu, KS; Treiber, DK; Zuercher, WJ; Willson, TM; 12:e0181585-PLoS ONE10.1371/journal.pone.018158501.1.2017
28655748Structural and functional analysis of the GABARAP interaction motif (GIM).Rogov VV, Stolz A, Ravichandran AC, Rios-Szwed DO, Suzuki H, Kniss A, Löhr F, Wakatsuki S, Dötsch V, Dikic I, Dobson RC, McEwan DG.18(8):1382-1396EMBO Rep10.15252/embr.20164358701.08.2017
28837155ZOMES: the intriguing interplay of PCI complexes and the ubiquitin in protein homeostasis.Alpi, AF; Echalier, A; 8:e3021-Cell Death and Disease10.1038/cddis.2017.41324.8.2017
28798097Suramin Inhibits Osteoarthritic Cartilage Degradation by Increasing Extracellular Levels of Chondroprotective Tissue Inhibitor of Metalloproteinases 3.Chanalaris, A; Doherty, C; Marsden, BD; Bambridge, G; Wren, SP; Nagase, H; Troeberg, L; 92:459-468Molecular Pharmacology10.1124/mol.117.10939701.10.2017
28733670BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis.Roberts, TC; Etxaniz, U; Dall'Agnese, A; Wu, S-Y; Chiang, C-M; Brennan, PE; Wood, MJA; Puri, PL; 7:6153-Scientific Reports10.1038/s41598-017-06483-721.7.2017
28706065Global analysis of protein folding using massively parallel design, synthesis, and testing.Rocklin GJ, Chidyausiku TM, Goreshnik I, Ford A, Houliston S, Lemak A, Carter L, Ravichandran R, Mulligan VK, Chevalier A, Arrowsmith CH, Baker D357(6347):168-175Science10.1126/science.aan069314.07.2017
28710492NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin.Melo-Hanchuk, TD; Slepicka, PF; Meirelles, GV; Basei, FL; Lovato, DV; Granato, DC; Pauletti, BA; Domingues, RR; Leme, AFP; Pelegrini, AL; Lenz, G; Knapp, S; Elkins, JM; Kobarg, J; 7:5445-Scientific Reports10.1038/s41598-017-05325-w14.7.2017
28712938ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells.Park NI, Guilhamon P, Desai K, McAdam RF, Langille E, O'Connor M, Lan X, Whetstone H, Coutinho FJ, Vanner RJ, Ling E, Prinos P, Lee L, Selvadurai H, Atwal G, Kushida M, Clarke ID, Voisin V, Cusimano MD, Bernstein M, Das S, Bader G, Arrowsmith CH, Angers S, Huang X, Lupien M, Dirks PBCell Stem Cell10.1016/j.stem.2017.06.00411.07.2017
28685254KH-TFMDI, a novel sirtuin inhibitor, alters the cytoskeleton and mitochondrial metabolism promoting cell death in Leishmania amazonensis.Verçoza, BRF; Godinho, JLP; de Macedo-Silva, ST; Huber, K; Bracher, F; de Souza, W; Rodrigues, JCF; 22:1169-1188Apoptosis10.1007/s10495-017-1397-801.9.2017
28648608Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly.Chaikuad, A; Filippakopoulos, P; Marcsisin, SR; Picaud, S; Schröder, M; Sekine, S; Ichijo, H; Engen, JR; Takeda, K; Knapp, S; 25:1089-1099.e3Structure10.1016/j.str.2017.05.02001.7.2017
Chaetocin sensitizes GBM cells to TRAIL and BH3 mimetics induced apoptosisOzyerli, E; Yesil, ZK; Oppermann, U; Onder, TB; 77:-Cancer Research10.1158/1538-7445.AM2017-587301.7.2017
28665395Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer.Wang, B-D; Ceniccola, K; Hwang, S; Andrawis, R; Horvath, A; Freedman, JA; Olender, J; Knapp, S; Ching, T; Garmire, L; Patel, V; Garcia-Blanco, MA; Patierno, SR; Lee, NH; 8:15921-15921Nature Communications10.1038/ncomms1592130.6.2017
28661476Ubiquitin-dependent regulation of Cdc42 by XIAP.Murali A, Shin J, Yurugi H, Krishnan A, Akutsu M, Carpy A, Macek B, Rajalingam K.8(6):e2900Cell Death Dis10.1038/cddis.2017.30529.06.2017
28662962Structure-activity relationship studies of G9a-like protein (GLP) inhibitors.Xiong Y, Li F, Babault N, Wu H, Dong A, Zeng H, Chen X, Arrowsmith CH, Brown PJ, Liu J, Vedadi M, Jin JBioorg. Med. Chem.10.1016/j.bmc.2017.06.02119.06.2017
28624569Readers, writers and erasers of N(6)-methylated adenosine modification.Wu B, Li L, Huang Y, Ma J, Min J47:67-76Curr. Opin. Struct. Biol.10.1016/j.sbi.2017.05.01115.06.2017
28596528Lapatinib potentiates cytotoxicity of  YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter.Radic-Sarikas, B; Halasz, M; Huber, KVM; Winter, GE; Tsafou, KP; Papamarkou, T; Brunak, S; Kolch, W; Superti-Furga, G; 7:3091-Scientific Reports10.1038/s41598-017-03129-68.6.2017
28591577Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer.Urbanucci, A; Barfeld, SJ; Kytölä, V; Itkonen, HM; Coleman, IM; Vodák, D; Sjöblom, L; Sheng, X; Tolonen, T; Minner, S; Burdelski, C; Kivinummi, KK; Kohvakka, A; Kregel, S; Takhar, M; Alshalalfa, M; Davicioni, E; Erho, N; Lloyd, P; Karnes, RJ; Ross, AE; Schaeffer, EM; Vander Griend, DJ; Knapp, S; Corey, E; Feng, FY; Nelson, PS; Saatcioglu, F; Knudsen, KE; Tammela, TLJ; Sauter, G; Schlomm, T; Nykter, M; Visakorpi, T; Mills, IG; 19:2045-2059Cell Reports10.1016/j.celrep.2017.05.04901.6.2017
28587923Generation and validation of intracellular ubiquitin variant inhibitors for USP7 and USP10.Zhang W, Sartori MA, Makhnevych T, Federowicz KE, Dong X, Liu L, Nim S, Dong A, Yang J, Li Y, Haddad D, Ernst A, Heerding D, Tong Y, Moffat J, Sidhu SSJ. Mol. Biol.10.1016/j.jmb.2017.05.02503.06.2017
28437395Global survey of the immunomodulatory potential of common drugs.Vladimer, GI; Snijder, B; Krall, N; Bigenzahn, JW; Huber, KVM; Lardeau, C-H; Sanjiv, K; Ringler, A; Berglund, UW; Sabler, M; de la Fuente, OL; Knöbl, P; Kubicek, S; Helleday, T; Jäger, U; Superti-Furga, G; 13:681-690Nature Chemical Biology10.1038/nchembio.236001.6.2017
28614707Linker Histone H1.2 Directs Genome-wide Chromatin Association of the Retinoblastoma Tumor Suppressor Protein and Facilitates Its Function.Munro, S; Hookway, ES; Floderer, M; Carr, SM; Konietzny, R; Kessler, BM; Oppermann, U; La Thangue, NB; 19:2193-2201Cell Reports10.1016/j.celrep.2017.05.05301.6.2017
Di-iodotyrosinated peptide imaging of cartilage (DIPIC)Fowkes, MM; Borges, PDN; Brennan, PE; Vincent, TL; Lim, NH; 98:A7-A7International Journal of Experimental Pathology01.6.2017
28373298MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway.Couzens, AL; Xiong, S; Knight, JDR; Mao, DY; Guettler, S; Picaud, S; Kurinov, I; Filippakopoulos, P; Sicheri, F; Gingras, AC; 16:1098-1110Molecular and Cellular Proteomics10.1074/mcp.m116.06549001.6.2017
28566431A trust approach for sharing research reagents.Edwards A, Morgan M, Al Chawaf A, Andrusiak K, Charney R, Cynader Z, ElDessouki A, Lee Y, Moeser A, Stern S, Zuercher WJ9(392):Sci Transl Med10.1126/scitranslmed.aai905531.05.2017
28603531Structural Characterization of Maize SIRK1 Kinase Domain Reveals an Unusual Architecture of the Activation Segment.Aquino, B; Couñago, RM; Verza, N; Ferreira, LM; Massirer, KB; Gileadi, O; Arruda, P; 8:852-852Frontiers in Plant Science10.3389/fpls.2017.0085226.5.2017
28526749The origin and evolution of human glutaminases and their atypical C-terminal ankyrin repeats.Pascoal, CC; Islam, Z; Adamoski, D; Ferreira, IM; Righetto, RD; Bettini, J; Portugal, RV; Yue, WW; Gonzalez, A; Dias, SMG; Ambrosio, ALB; :-Journal of Biological Chemistry10.1074/jbc.M117.78729119.5.2017
28504695Epigenetic pathway inhibitors represent potential drugs for treating pancreatic and bronchial neuroendocrine tumors.Lines, KE; Stevenson, M; Filippakopoulos, P; Müller, S; Lockstone, HE; Wright, B; Grozinsky-Glasberg, S; Grossman, AB; Knapp, S; Buck, D; Bountra, C; Thakker, RV; 6:e332-Oncogenesis10.1038/oncsis.2017.3015.5.2017
28497574Protein destabilization and loss of protein-protein interaction are fundamental mechanisms in cblA-type methylmalonic aciduria.Plessl, T; Bürer, C; Lutz, S; Yue, WW; Baumgartner, MR; Froese, DS; :-Human Mutation10.1002/humu.2325112.5.2017
28375629Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain.Denny, RA; Flick, AC; Coe, J; Langille, J; Basak, A; Liu, S; Stock, I; Sahasrabudhe, P; Bonin, P; Hay, DA; Brennan, PE; Pletcher, M; Jones, LH; Chekler, ELP; 60:5349-5363Journal of Medicinal Chemistry10.1021/acs.jmedchem.6b0183901.7.2017
28485044A Specific and Covalent JNK-1 Ligand Selected from an Encoded Self-Assembling Chemical Library.Zimmermann, G; Rieder, U; Bajic, D; Vanetti, S; Chaikuad, A; Knapp, S; Scheuermann, J; Mattarella, M; Neri, D; 23:8152-8155Chemistry - A European Journal10.1002/chem.20170164401.6.2017
28465421Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome.Kashima, R; Redmond, PL; Ghatpande, P; Roy, S; Kornberg, TB; Hanke, T; Knapp, S; Lagna, G; Hata, A; 10:-Science Signaling10.1126/scisignal.aai81332.5.2017
29308121Histone lysine methyltransferase structure activity relationships that allow for segregation of G9a inhibition and anti-Plasmodium activity.Sundriyal S, Chen PB, Lubin AS, Lueg GA, Li F, White AJP, Malmquist NA, Vedadi M, Scherf A, Fuchter MJ8(5):1069-1092Medchemcomm10.1039/c7md00052a01.05.2017
28267269Oxalyl Boronates Enable Modular Synthesis of Bioactive Imidazoles.Lee, CF; Holownia, A; Bennett, JM; Elkins, JM; St Denis, JD; Adachi, S; Yudin, AK; 56:6264-6267Angewandte Chemie International Edition10.1002/anie.20161100601.5.2017
28436492A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.Pearce, NM; Krojer, T; Bradley, AR; Collins, P; Nowak, RP; Talon, R; Marsden, BD; Kelm, S; Shi, J; Deane, CM; von Delft, F; 8:15123-Nature Communications10.1038/ncomms1512324.4.2017
28406400The RNF168 paralog RNF169 defines a new class of ubiquitylated-histone reader involved in the response to DNA damage.Kitevski-LeBlanc J, Fradet-Turcotte A, Kukic P, Wilson MD, Portella G, Yuwen T, Panier S, Duan S, Canny MD, van Ingen H, Arrowsmith CH, Rubinstein JL, Vendruscolo M, Durocher D, Kay LE6:Elife10.7554/eLife.2387213.04.2017
28402630Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains.Bouché, L; Christ, CD; Siegel, S; Fernández-Montalván, AE; Holton, SJ; Fedorov, O; Ter Laak, A; Sugawara, T; Stöckigt, D; Tallant, C; Bennett, J; Monteiro, O; Díaz-Sáez, L; Siejka, P; Meier, J; Pütter, V; Weiske, J; Müller, S; Huber, KVM; Hartung, IV; Haendler, B; 60:4002-4022Journal of Medicinal Chemistry10.1021/acs.jmedchem.7b0030601.5.2017
28382930Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.Kawamura, A; Münzel, M; Kojima, T; Yapp, C; Bhushan, B; Goto, Y; Tumber, A; Katoh, T; King, ONF; Passioura, T; Walport, LJ; Hatch, SB; Madden, S; Müller, S; Brennan, PE; Chowdhury, R; Hopkinson, RJ; Suga, H; Schofield, CJ; 8:14773-Nature Communications10.1038/ncomms147736.4.2017
28383693Molecular basis for the methylation specificity of ATXR5 for histone H3.Bergamin E, Sarvan S, Malette J, Eram MS, Yeung S, Mongeon V, Joshi M, Brunzelle JS, Michaels SD, Blais A, Vedadi M, Couture JFNucleic Acids Res.10.1093/nar/gkx22405.04.2017
Virtual fragment screening and linking discovers Jumonji histone demethylase inhibitorsKorczynska, M; Le, D; Siklos, M; Younger, N; Gregori-Puigjane, E; Tumber, A; Krojer, T; Velupillai, S; Gileadi, C; Nowak, R; Iwasa, E; Pollock, S; Torres, IO; Oppermann, U; Shoichet, B; Fujimori, D; 253:-ACS National Meeting Book of Abstracts2.4.2017
Development of a potent and selective bromodomain chemical probeMoustakim, M; Brennan, P; Dixon, D; 253:-ACS National Meeting Book of Abstracts2.4.2017
DEVELOPMENT OF QUANTITATIVE IN VIVO IMAGING OF ARTICULAR CARTILAGE DEGRADATION IN MURINE OSTEOARTHRITISBorges, PDN; Fowkes, MM; Brennan, PE; Vincent, TL; Lim, NH; 25:S33-S34Osteoarthritis and Cartilage01.4.2017
28100692Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.Newman, JA; Aitkenhead, H; Savitsky, P; Gileadi, O; 45:4231-4243Nucleic Acids Research10.1093/nar/gkw136201.4.2017
28345007Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites.Pearce, NM; Bradley, AR; Krojer, T; Marsden, BD; Deane, CM; von Delft, F; 4:032104-Structural Dynamics10.1063/1.497417601.5.2017
28392258Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.Aryal, P; Jarerattanachat, V; Clausen, MV; Schewe, M; McClenaghan, C; Argent, L; Conrad, LJ; Dong, YY; Pike, ACW; Carpenter, EP; Baukrowitz, T; Sansom, MSP; Tucker, SJ; 25:708-718.e2Structure10.1016/j.str.2017.03.00601.5.2017
28369529Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation.Gao Y, Zhang Q, Lang Y, Liu Y, Dong X, Chen Z, Tian W, Tang J, Wu W, Tong Y, Chen ZJ Mol Cell Biol10.1093/jmcb/mjx01020.03.2017
28306378Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1.Santamaria, S; Fedorov, O; McCafferty, J; Murphy, G; Dudhia, J; Nagase, H; Yamamoto, K; :0-0mAbs10.1080/19420862.2017.130434117.3.2017
28337325Tetrahydroisoquinoline-7-carboxamide Derivatives as New Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors.Wang, Z; Zhang, Y; Bartual, SG; Luo, J; Xu, T; Du, W; Xun, Q; Tu, Z; Brekken, RA; Ren, X; Bullock, AN; Liang, G; Lu, X; Ding, K; 8:327-332ACS Medicinal Chemistry Letters10.1021/acsmedchemlett.6b0049701.3.2017
28291760Gentle, fast and effective crystal soaking by acoustic dispensing.Collins, PM; Ng, JT; Talon, R; Nekrosiute, K; Krojer, T; Douangamath, A; Brandao-Neto, J; Wright, N; Pearce, NM; von Delft, F; 73:246-255Acta Crystallographica. Section d, Structural Biology10.1107/S205979831700331X6.3.2017
28291761Proper modelling of ligand binding requires an ensemble of bound and unbound states.Pearce, NM; Krojer, T; von Delft, F; 73:256-266Acta Crystallographica. Section d, Structural Biology10.1107/S20597983170034126.3.2017
28255880Antibody Validation by Immunoprecipitation Followed by Mass Spectrometry Analysis.Persson H, Preger C, Marcon E, Lengqvist J, Gräslund S1575:175-187Methods Mol. Biol.10.1007/978-1-4939-6857-2_1004.03.2017
28262558Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.Tumber, A; Nuzzi, A; Hookway, ES; Hatch, SB; Velupillai, S; Johansson, C; Kawamura, A; Savitsky, P; Yapp, C; Szykowska, A; Wu, N; Bountra, C; Strain-Damerell, C; Burgess-Brown, NA; Ruda, GF; Fedorov, O; Munro, S; England, KS; Nowak, RP; Schofield, CJ; La Thangue, NB; Pawlyn, C; Davies, F; Morgan, G; Athanasou, N; Müller, S; Oppermann, U; Brennan, PE; 24:371-380Cell Chemical Biology10.1016/j.chembiol.2017.02.0062.3.2017
IDENTIFICATION OF CHROMATIN MODIFYING MECHANISMS IN INFLAMMATORY MACROPHAGES IN RHEUMATOID ARTHRITISRooke, K; Mander, P; Kruidenier, L; Martinez, F; Al-Mossawi, H; Bowness, P; Swales, C; Prinjha, R; Oppermann, U; 76:A38-A38Annals of the Rheumatic Diseases10.1136/annrheumdis-2016-211049.2001.3.2017
28291762The XChemExplorer graphical workflow tool for routine or large-scale protein-ligand structure determination.Krojer, T; Talon, R; Pearce, N; Collins, P; Douangamath, A; Brandao-Neto, J; Dias, A; Marsden, B; von Delft, F; 73:267-278Acta Crystallographica. Section d, Structural Biology10.1107/S205979831602023401.3.2017
28265301Assessing histone demethylase inhibitors in cells: lessons learned.Hatch, SB; Yapp, C; Montenegro, RC; Savitsky, P; Gamble, V; Tumber, A; Ruda, GF; Bavetsias, V; Fedorov, O; Atrash, B; Raynaud, F; Lanigan, R; Carmichael, L; Tomlin, K; Burke, R; Westaway, SM; Brown, JA; Prinjha, RK; Martinez, ED; Oppermann, U; Schofield, CJ; Bountra, C; Kawamura, A; Blagg, J; Brennan, PE; Rossanese, O; Müller, S; 10:9-Epigenetics and Chromatin10.1186/s13072-017-0116-601.1.2017
27810991Selective silencing of α-globin by the histone demethylase inhibitor IOX1: a potentially new pathway for treatment of β-thalassemia.Mettananda, S; Fisher, CA; Sloane-Stanley, JA; Taylor, S; Oppermann, U; Gibbons, RJ; Higgs, DR; 102:e80-e84Haematologica10.3324/haematol.2016.15565501.3.2017
28291763WONKA and OOMMPPAA: analysis of protein-ligand interaction data to direct structure-based drug design.Deane, CM; Wall, ID; Green, DVS; Marsden, BD; Bradley, AR; 73:279-285Acta Crystallographica. Section d, Structural Biology10.1107/S205979831600952901.3.2017
28341403Thiazolidine derivatives as potent and selective inhibitors of the PIM kinase family.Bataille, CJR; Brennan, MB; Byrne, S; Davies, SG; Durbin, M; Fedorov, O; Huber, KVM; Jones, AM; Knapp, S; Liu, G; Nadali, A; Quevedo, CE; Russell, AJ; Walker, RG; Westwood, R; Wynne, GM; 25:2657-2665Bioorganic and Medicinal Chemistry10.1016/j.bmc.2017.02.05601.5.2017
28223359Peptide recognition by HP1 chromoshadow domains revisited: plasticity in the pseudosymmetric histone binding site of human HP1.Liu Y, Qin S, Lei M, Tempel W, Zhang Y, Loppnau P, Li Y, Min JJ. Biol. Chem.10.1074/jbc.M116.76837421.02.2017
28028054Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins.Stolz A, Putyrski M, Kutle I, Huber J, Wang C, Major V, Sidhu SS, Youle RJ, Rogov VV, Dötsch V, Ernst A, Dikic I.36(4):549-564EMBO J10.15252/embj.20169506315.02.2017
28199324Establishing a reliable framework for harnessing the creative power of the scientific crowd.Carter, AJ; Donner, A; Lee, WH; Bountra, C; 15:e2001387-PLoS Biology10.1371/journal.pbio.200138715.2.2017
28165227Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2.Barnash KD, The J, Norris-Drouin JL, Cholensky SH, Worley BM, Li F, Stuckey JI, Brown PJ, Vedadi M, Arrowsmith CH, Frye SV, James LIACS Comb Sci10.1021/acscombsci.6b0017406.02.2017
28160335Targeting human SET1/MLL family of proteins.Vedadi M, Blazer L, Eram MS, Barsyte-Lovejoy D, Arrowsmith CH, Hajian TProtein Sci.10.1002/pro.312904.02.2017
Conformational Plasticity of the MAGE-A3 Protein as a Therapeutic Strategy in Multiple MyelomaOsman, R; Cho, HJ; Gileadi, O; 112:340A-340ABiophysical Journal10.1016/j.bpj.2016.11.18403.2.2017
Structural and Functional Response of a Mechanosensitive K2P K+ Channel to Asymmetric Membrane TensionJarerattanachat, V; Clausen, MV; Aryal, P; Carpenter, EP; Sansom, MSP; Tucker, SJ; :-Biophysical Journal3.2.2017
26970254Expanding the genotypic spectrum of Perrault syndrome.Demain, LAM; Urquhart, JE; O'Sullivan, J; Williams, SG; Bhaskar, SS; Jenkinson, EM; Lourenco, CM; Heiberg, A; Pearce, SH; Shalev, SA; Yue, WW; Mackinnon, S; Munro, KJ; Newbury-Ecob, R; Becker, K; Kim, MJ; O' Keefe, RT; Newman, WG; 91:302-312Clinical Genetics10.1111/cge.1277601.2.2017
27991905Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).Grieben, M; Pike, ACW; Shintre, CA; Venturi, E; El-Ajouz, S; Tessitore, A; Shrestha, L; Mukhopadhyay, S; Mahajan, P; Chalk, R; Burgess-Brown, NA; Sitsapesan, R; Huiskonen, JT; Carpenter, EP; 24:114-122Nature Structural and Molecular Biology10.1038/nsmb.334301.2.2017
28057719Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16.Dixon-Clarke, SE; Shehata, SN; Krojer, T; Sharpe, TD; von Delft, F; Sakamoto, K; Bullock, AN; 474:699-713Biochemical Journal10.1042/BCJ2016094120.2.2017
28135237The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.He Y, Selvaraju S, Curtin ML, Jakob CG, Zhu H, Comess KM, Shaw B, The J, Lima-Fernandes E, Szewczyk MM, Cheng D, Klinge KL, Li HQ, Pliushchev M, Algire MA, Maag D, Guo J, Dietrich J, Panchal SC, Petros AM, Sweis RF, Torrent M, Bigelow LJ, Senisterra G, Li F, Kennedy S, Wu Q, Osterling DJ, Lindley DJ, Gao W, Galasinski S, Barsyte-Lovejoy D, Vedadi M, Buchanan FG, Arrowsmith CH, Chiang GG, Sun C, Pappano WNNat. Chem. Biol.10.1038/nchembio.230630.01.2017
28135068Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.Batson, J; Toop, HD; Redondo, C; Babaei-Jadidi, R; Chaikuad, A; Wearmouth, SF; Gibbons, B; Allen, C; Tallant, C; Zhang, J; Du, C; Hancox, JC; Hawtrey, T; Da Rocha, J; Griffith, R; Knapp, S; Bates, DO; Morris, JC; 12:825-832ACS Chemical Biology10.1021/acschembio.6b0104830.1.2017
28135087Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.Xiong Y, Li F, Babault N, Dong A, Zeng H, Wu H, Chen X, Arrowsmith CH, Brown PJ, Liu J, Vedadi M, Jin JJ. Med. Chem.10.1021/acs.jmedchem.6b0164530.01.2017
28039837Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines.Hylsová, M; Carbain, B; Fanfrlík, J; Musilová, L; Haldar, S; Köprülüoğlu, C; Ajani, H; Brahmkshatriya, PS; Jorda, R; Kryštof, V; Hobza, P; Echalier, A; Paruch, K; Lepšík, M; 126:1118-1128European Journal of Medicinal Chemistry10.1016/j.ejmech.2016.12.02327.1.2017
28162900Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor.Osman KT, Ye J, Shi Z, Toker C, Lovato D, Jumani RS, Zuercher W, Huston CD, Edwards AM, Lautens M, Santhakumar V, Hui RBioorg. Med. Chem.10.1016/j.bmc.2017.01.03624.01.2017
28114273The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.Bromberg KD, Mitchell TR, Upadhyay AK, Jakob CG, Jhala MA, Comess KM, Lasko LM, Li C, Tuzon CT, Dai Y, Li F, Eram MS, Nuber A, Soni NB, Manaves V, Algire MA, Sweis RF, Torrent M, Schotta G, Sun C, Michaelides MR, Shoemaker AR, Arrowsmith CH, Brown PJ, Santhakumar V, Martin A, Rice JC, Chiang GG, Vedadi M, Barsyte-Lovejoy D, Pappano WNNat. Chem. Biol.10.1038/nchembio.228223.01.2017
28103226Target engagement: Shining a light.Huber, KVM;13:133-134Nature Chemical Biology10.1038/nchembio.229501.1.2017
28092368Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2.Wilkes, M; Madej, MG; Kreuter, L; Rhinow, D; Heinz, V; De Sanctis, S; Ruppel, S; Richter, RM; Joos, F; Grieben, M; Pike, ACW; Huiskonen, JT; Carpenter, EP; Kühlbrandt, W; Witzgall, R; Ziegler, C; 24:123-130Nature Structural and Molecular Biology10.1038/nsmb.335701.2.2017
28080202Chemical Probes Targeting Epigenetic Proteins: Applications Beyond Oncology.Ackloo S, Brown PJ, Müller S0Epigenetics10.1080/15592294.2017.127937112.01.2017
28073004Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma.Veschi V, Liu Z, Voss TC, Ozbun L, Gryder B, Yan C, Hu Y, Ma A, Jin J, Mazur SJ, Lam N, Souza BK, Giannini G, Hager GL, Arrowsmith CH, Khan J, Appella E, Thiele CJ31(1):50-63Cancer Cell10.1016/j.ccell.2016.12.00209.01.2017
28068087Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies.Igoe, N; Bayle, ED; Fedorov, O; Tallant, C; Savitsky, P; Rogers, C; Owen, DR; Deb, G; Somervaille, TCP; Andrews, DM; Jones, N; Cheasty, A; Ryder, H; Brennan, PE; Müller, S; Knapp, S; Fish, PV; 60:668-680Journal of Medicinal Chemistry10.1021/acs.jmedchem.6b015839.1.2017
28053347Functions of bromodomain-containing proteins and their roles in homeostasis and cancer.Fujisawa, T; Filippakopoulos, P; 18:246-262Nature Reviews Molecular Cell Biology10.1038/nrm.2016.14301.4.2017
CHAPTER 3: Targeting Catalytic and Non-Catalytic Functions of Protein KinasesMüller, S; Knapp, S; 2017-January:40-64RSC Drug Discovery Series10.1039/9781782629276-000401.1.2017
28470595Recombinant Protein Expression in E. coli : A Historical Perspective.Gileadi, O;1586:3-10Methods in Molecular Biology10.1007/978-1-4939-6887-9_101.1.2017
28470596N- and C-Terminal Truncations to Enhance Protein Solubility and Crystallization: Predicting Protein Domain Boundaries with Bioinformatics Tools.Cooper, CDO; Marsden, BD; 1586:11-31Methods in Molecular Biology10.1007/978-1-4939-6887-9_201.1.2017
Bromodomains control amyloid-like aggregation of aberrantly acetylated proteins.Olzscha, H; Fedorov, O; Kessler, BM; Knapp, S; La Thangue, NB; 28:-Molecular Biology of the Cell01.01.2017
28062706Combinatorial Drug Screening Identifies Ewing Sarcoma-specific Sensitivities.Radic-Sarikas, B; Tsafou, KP; Emdal, KB; Papamarkou, T; Huber, KVM; Mutz, C; Toretsky, JA; Bennett, KL; Olsen, JV; Brunak, S; Kovar, H; Superti-Furga, G; 16:88-101Molecular Cancer Therapeutics10.1158/1535-7163.mct-16-023501.1.2017
28009512Predictions of Ligand Selectivity from Absolute Binding Free Energy Calculations.Aldeghi, M; Heifetz, A; Bodkin, MJ; Knapp, S; Biggin, PC; 139:946-957Journal of the American Chemical Society10.1021/jacs.6b114679.1.2017
27989401CBP/p300 Bromodomains Regulate Amyloid-like Protein Aggregation upon Aberrant Lysine Acetylation.Olzscha, H; Fedorov, O; Kessler, BM; Knapp, S; La Thangue, NB; 24:9-23Cell Chemical Biology10.1016/j.chembiol.2016.11.00901.1.2017
27916275Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity.Li, J; Casteels, T; Frogne, T; Ingvorsen, C; Honoré, C; Courtney, M; Huber, KVM; Schmitner, N; Kimmel, RA; Romanov, RA; Sturtzel, C; Lardeau, C-H; Klughammer, J; Farlik, M; Sdelci, S; Vieira, A; Avolio, F; Briand, F; Baburin, I; Májek, P; Pauler, FM; Penz, T; Stukalov, A; Gridling, M; Parapatics, K; Barbieux, C; Berishvili, E; Spittler, A; Colinge, J; Bennett, KL; Hering, S; Sulpice, T; Bock, C; Distel, M; Harkany, T; Meyer, D; Superti-Furga, G; Collombat, P; Hecksher-Sørensen, J; Kubicek, S; 168:86-100.e15Cell10.1016/j.cell.2016.11.01001.1.2017
27678457The MAPK Pathway Regulates Intrinsic Resistance to BET Inhibitors in Colorectal Cancer.Ma, Y; Wang, L; Neitzel, LR; Loganathan, SN; Tang, N; Qin, L; Crispi, EE; Guo, Y; Knapp, S; Beauchamp, RD; Lee, E; Wang, J; 23:2027-2037Clinical Cancer Research10.1158/1078-0432.CCR-16-045301.4.2017
27651452BRD4 localization to lineage-specific enhancers is associated with a distinct transcription factor repertoire.Najafova, Z; Tirado-Magallanes, R; Subramaniam, M; Hossan, T; Schmidt, G; Nagarajan, S; Baumgart, SJ; Mishra, VK; Bedi, U; Hesse, E; Knapp, S; Hawse, JR; Johnsen, SA; 45:127-141Nucleic Acids Research10.1093/nar/gkw82601.1.2017
27292261The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer.da Motta, LL; Ledaki, I; Purshouse, K; Haider, S; De Bastiani, MA; Baban, D; Morotti, M; Steers, G; Wigfield, S; Bridges, E; Li, J-L; Knapp, S; Ebner, D; Klamt, F; Harris, AL; McIntyre, A; 36:122-132Oncogene10.1038/onc.2016.18401.1.2017
27028588The first international workshop on the epigenetics of osteoarthritis.Meulenbelt, IM; Bhutani, N; den Hollander, W; Gay, S; Oppermann, U; Reynard, LN; Skelton, AJ; Young, DA; Beier, F; Loughlin, J; 58:37-48Connective Tissue Research10.3109/03008207.2016.116840901.1.2017
28034915Early-life antibiotic treatment enhances the pathogenicity of CD4+ T cells during intestinal inflammation.Scheer S, Medina TS, Murison A, Taves MD, Antignano F, Chenery A, Soma KK, Perona-Wright G, Lupien M, Arrowsmith CH, De Carvalho DD, Zaph CJ. Leukoc. Biol.10.1189/jlb.3MA0716-334RR29.12.2016
28060271Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures.Morrison, E; Wai, P; Leonidou, A; Bland, P; Khalique, S; Farnie, G; Daley, F; Peck, B; Natrajan, R; :-Journal of Visualized Experiments10.3791/5473826.12.2016
28000414Identification of CLK1 Inhibitors by a Fragment-linking Based Virtual Screening.Walter, A; Chaikuad, A; Loaëc, N; Preu, L; Knapp, S; Meijer, L; Kunick, C; Koch, O; 36:-Molecular Informatics10.1002/minf.20160012321.12.2016
27980063BRD4 promotes p63 and GRHL3 expression downstream of FOXO in mammary epithelial cells.Nagarajan, S; Bedi, U; Budida, A; Hamdan, FH; Mishra, VK; Najafova, Z; Xie, W; Alawi, M; Indenbirken, D; Knapp, S; Chiang, C-M; Grundhoff, A; Kari, V; Scheel, CH; Wegwitz, F; Johnsen, SA; 45:3130-3145Nucleic Acids Research10.1093/nar/gkw127615.12.2016
27966810Discovery of a PCAF Bromodomain Chemical Probe.Moustakim M, Clark PG, Trulli L, Fuentes de Arriba AL, Ehebauer MT, Chaikuad A, Murphy EJ, Mendez-Johnson J, Daniels D, Hou CD, Lin YH, Walker JR, Hui R, Yang H, Dorrell L, Rogers CM, Monteiro OP, Fedorov O, Huber KV, Knapp S, Heer J, Dixon DJ, Brennan PEAngew. Chem. Int. Ed. Engl.10.1002/anie.20161081614.12.2016
27960086Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.Torchia J, Golbourn B, Feng S, Ho KC, Sin-Chan P, Vasiljevic A, Norman JD, Guilhamon P, Garzia L, Agamez NR, Lu M, Chan TS, Picard D, de Antonellis P, Khuong-Quang DA, Planello AC, Zeller C, Barsyte-Lovejoy D, Lafay-Cousin L, Letourneau L, Bourgey M, Yu M, Gendoo DM, Dzamba M, Barszczyk M, Medina T, Riemenschneider AN, Morrissy AS, Ra YS, Ramaswamy V, Remke M, Dunham CP, Yip S, Ng HK, Lu JQ, Mehta V, Albrecht S, Pimentel J, Chan JA, Somers GR, Faria CC, Roque L, Fouladi M, Hoffman LM, Moore AS, Wang Y, Choi SA, Hansford JR, Catchpoole D, Birks DK, Foreman NK, Strother D, Klekner A, Bognár L, Garami M, Hauser P, Hortobágyi T, Wilson B, Hukin J, Carret AS, Van Meter TE, Hwang EI, Gajjar A, Chiou SH, Nakamura H, Toledano H, Fried I, Fults D, Wataya T, Fryer C, Eisenstat DD, Scheinemann K, Fleming AJ, Johnston DL, Michaud J, Zelcer S, Hammond R, Afzal S, Ramsay DA, Sirachainan N, Hongeng S, Larbcharoensub N, Grundy RG, Lulla RR, Fangusaro JR, Druker H, Bartels U, Grant R, Malkin D, McGlade CJ, Nicolaides T, Tihan T, Phillips J, Majewski J, Montpetit A, Bourque G, Bader GD, Reddy AT, Gillespie GY, Warmuth-Metz M, Rutkowski S, Tabori U, Lupien M, Brudno M, Schüller U, Pietsch T, Judkins AR, Hawkins CE, Bouffet E, Kim SK, Dirks PB, Taylor MD, Erdreich-Epstein A, Arrowsmith CH, De Carvalho DD, Rutka JT, Jabado N, Huang A30(6):891-908Cancer Cell10.1016/j.ccell.2016.11.00312.12.2016
27934875Functional and structural characterization of a novel putative cysteine protease cell wall-modifying multi-domain enzyme selected from a microbial metagenome.Faheem, M; Martins-de-Sa, D; Vidal, JFD; Álvares, ACM; Brandão-Neto, J; Bird, LE; Tully, MD; von Delft, F; Souto, BM; Quirino, BF; Freitas, SM; Barbosa, JARG; 6:38031-Scientific Reports10.1038/srep380319.12.2016
27994746Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8.Judge RA, Zhu H, Upadhyay AK, Bodelle PM, Hutchins CW, Torrent M, Marin VL, Yu W, Vedadi M, Li F, Brown PJ, Pappano WN, Sun C, Petros AM7(12):1102-1106ACS Med Chem Lett10.1021/acsmedchemlett.6b0030308.12.2016
27926874Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin.Savitsky P, Krojer T, Fujisawa T, Lambert JP, Picaud S, Wang CY, Shanle EK, Krajewski K, Friedrichsen H, Kanapin A, Goding C, Schapira M, Samsonova A, Strahl BD, Gingras AC, Filippakopoulos P17(10):2724-2737Cell Rep10.1016/j.celrep.2016.11.01406.12.2016
27798618Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions.Martins, R; Maier, J; Gorki, A-D; Huber, KVM; Sharif, O; Starkl, P; Saluzzo, S; Quattrone, F; Gawish, R; Lakovits, K; Aichinger, MC; Radic-Sarikas, B; Lardeau, C-H; Hladik, A; Korosec, A; Brown, M; Vaahtomeri, K; Duggan, M; Kerjaschki, D; Esterbauer, H; Colinge, J; Eisenbarth, SC; Decker, T; Bennett, KL; Kubicek, S; Sixt, M; Superti-Furga, G; Knapp, S; 17:1361-1372Nature Immunology10.1038/ni.359001.12.2016
Examining the role of chromatin modifying enzymes in medulloblastoma by utilizing a chemical libraryLokumcu, T; Senbabaoglu, F; Oppermann, U; Bagci-Onder, T; 69:S49-S49European Journal of Cancer10.1016/S0959-8049(16)32730-701.12.2016
27874871Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24.Mehmood, S; Marcoux, J; Gault, J; Quigley, A; Michaelis, S; Young, SG; Carpenter, EP; Robinson, CV; 8:1152-1158Nature Chemistry10.1038/nchem.259101.12.2016
27680982Patient-derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis.Eyre, R; Alférez, DG; Spence, K; Kamal, M; Shaw, FL; Simões, BM; Santiago-Gómez, A; Sarmiento-Castro, A; Bramley, M; Absar, M; Saad, Z; Chatterjee, S; Kirwan, C; Gandhi, A; Armstrong, AC; Wardley, AM; O'Brien, CS; Farnie, G; Howell, SJ; Clarke, RB; 21:99-109Journal of Mammary Gland Biology and Neoplasia10.1007/s10911-016-9361-801.12.2016
Patient-derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to MetastasisEyre, R; Alférez, DG; Spence, K; Kamal, M; Shaw, FL; Simões, BM; Santiago-Gómez, A; Sarmiento-Castro, A; Bramley, M; Absar, M; Saad, Z; Chatterjee, S; Kirwan, C; Gandhi, A; Armstrong, AC; Wardley, AM; O'Brien, CS; Farnie, G; Howell, SJ; Clarke, RB; 21:99-109Journal of Mammary Gland Biology and Neoplasia1.12.2016
27482375Dendritic and mast cell involvement in the inflammatory response to primary malignant bone tumours.Inagaki, Y; Hookway, E; Williams, KA; Hassan, AB; Oppermann, U; Tanaka, Y; Soilleux, E; Athanasou, NA; 6:13-Clinical Sarcoma Research10.1186/s13569-016-0053-301.1.2016
Herpes simplex virus specific T cell response in a cohort with primary genital infection correlates inversely with frequency of subsequent recurrences. Sexually transmitted infections 2016Franzen-Röhl E, Schepis D, Atterfelt F, Franck K, Wikström A, Liljeqvist JÅ, Bergström T, Aurelius E, Kärre K, Berg L, Gaines H.BMJ Journals10.1136/sextrans-2016-05281130.11.2016
27766861An Unusual Binding Model of the Methyl 9-Anilinothiazolo[5,4-f] quinazoline-2-carbimidates (EHT 1610 and EHT 5372) Confers High Selectivity for Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases.Chaikuad, A; Diharce, J; Schröder, M; Foucourt, A; Leblond, B; Casagrande, A-S; Désiré, L; Bonnet, P; Knapp, S; Besson, T; 59:10315-10321Journal of Medicinal Chemistry10.1021/acs.jmedchem.6b010832.11.2016
27871366Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair.Vaz, B; Popovic, M; Newman, JA; Fielden, J; Aitkenhead, H; Halder, S; Singh, AN; Vendrell, I; Fischer, R; Torrecilla, I; Drobnitzky, N; Freire, R; Amor, DJ; Lockhart, PJ; Kessler, BM; McKenna, GW; Gileadi, O; Ramadan, K; 64:704-719Molecular Cell10.1016/j.molcel.2016.09.03201.11.2016
27840070Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket.Forster, M; Chaikuad, A; Bauer, SM; Holstein, J; Robers, MB; Corona, CR; Gehringer, M; Pfaffenrot, E; Ghoreschi, K; Knapp, S; Laufer, SA; 23:1335-1340Cell Chemical Biology10.1016/j.chembiol.2016.10.00810.11.2016
27815673Erratum to: Patient-Derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis.Eyre, R; Alférez, DG; Spence, K; Kamal, M; Shaw, FL; Simões, BM; Santiago-Gómez, A; Sarmiento-Castro, A; Bramley, M; Absar, M; Saad, Z; Chatterjee, S; Kirwan, C; Gandhi, A; Armstrong, AC; Wardley, AM; O'Brien, CS; Farnie, G; Howell, SJ; Clarke, RB; 21:111-Journal of Mammary Gland Biology and Neoplasia10.1007/s10911-016-9364-501.12.2016
27810991Selective silencing of alpha-globin by the histone demethylase inhibitor IOX1: A potentially new pathway for treatment of beta-thalassemia.Mettananda S, Fisher CA, Sloane-Stanley JA, Taylor S, Oppermann U, Gibbons RJ, Higgs DR. Haematologicahttps://dx.doi.org/10.3324/haematol.2016.15565503/11/2016
27804297Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.Butler KV, Ma A, Yu W, Li F, Tempel W, Babault N, Pittella-Silva F, Shao J, Wang J, Luo M, Vedadi M, Brown PJ, Arrowsmith CH, Jin JJ. Med. Chem.10.1021/acs.jmedchem.6b0124402.11.2016
ASSESSING THE FUNCTION OF CHROMATIN MODIFYING ENZYMES IN MEDULLOBLASTOMALokumcu, T; Senbabaoglu, F; Oppermann, U; Bagci-Onder, T; 18:153-153Neuro-Oncology01.11.2016
27881600Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly.Xu C, Ishikawa H, Izumikawa K, Li L, He H, Nobe Y, Yamauchi Y, Shahjee HM, Wu XH, Yu YT, Isobe T, Takahashi N, Min J30(21):2376-2390Genes Dev.10.1101/gad.288340.11601.11.2016
PRECLINICAL EFFICACY OF ALK2 INHIBITORS IN ACVR1 MUTANT DIPGCarvalho, D; Taylor, K; Olaciregui, NG; Valenti, M; Ruddle, R; Henley, A; Hayes, A; Brandon, ADH; MacKay, A; Molinari, V; Vinci, M; Popov, S; Brennan, P; Moore, A; Hudson, L; Hoelder, S; Bullock, A; Raynaud, F; Eccles, S; Carcaboso, AM; Jones, C; 18:154-154Neuro-Oncology01.11.2016
27846394Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP.Lu, M; Breyssens, H; Salter, V; Zhong, S; Hu, Y; Baer, C; Ratnayaka, I; Sullivan, A; Brown, NR; Endicott, J; Knapp, S; Kessler, BM; Middleton, MR; Siebold, C; Jones, EY; Sviderskaya, EV; Cebon, J; John, T; Caballero, OL; Goding, CR; Lu, X; 30:822-823Cancer Cell10.1016/j.ccell.2016.09.01901.11.2016
27798837Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.Nakazawa Hewitt S, Dranow DM, Horst BG, Abendroth JA, Forte B, Hallyburton I, Jansen C, Baragana B, Choi R, Rivas KL, Hulverson MA, Dumais M, Edwards TE, Lorimer DD, Fairlamb AH, Gray DW, Read KD, Lehane AM, Kirk K, Myler PJ, Wernimont A, Walpole CS, Stacy R, Barrett LK, Gilbert IH, Van Voorhis WCACS Infect Dis10.1021/acsinfecdis.6b0007831.10.2016
27787844Characterizing Plexin GTPase Interactions Using Gel Filtration, Surface Plasmon Resonance Spectrometry, and Isothermal Titration Calorimetry.Muller-Greven J, Kim S, Hota PK, Tong Y, Borthakur S, Buck M1493:89-105Methods Mol. Biol.10.1007/978-1-4939-6448-2_628.10.2016
27771863Solution NMR structure of the HLTF HIRAN domain: a conserved module in SWI2/SNF2 DNA damage tolerance proteins.Korzhnev DM, Neculai D, Dhe-Paganon S, Arrowsmith CH, Bezsonova IJ. Biomol. NMR10.1007/s10858-016-0070-922.10.2016
27776223The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear.Zhang Q, Wang Z, Hou F, Harding R, Huang X, Dong A, Walker JR, Tong YBiochim. Biophys. Acta10.1016/j.bbagen.2016.10.01921.10.2016
27732584Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.Mevissen TET, Kulathu Y, Mulder MPC, Geurink PP, Maslen SL, Gersch M, Elliott PR, Burke JE, van Tol BDM, Akutsu M, Oualid FE, Kawasaki M, Freund SMV, Ovaa H, Komander D.538(7625):402-405Nature10.1038/nature1983620.10.2016
27716744Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization.Gebel, J; Luh, LM; Coutandin, D; Osterburg, C; Löhr, F; Schäfer, B; Frombach, A-S; Sumyk, M; Buchner, L; Krojer, T; Salah, E; Mathea, S; Güntert, P; Knapp, S; Dötsch, V; 23:1930-1940Cell Death and Differentiation10.1038/cdd.2016.8301.12.2016
27322439A standardized clinical evaluation of phenotypic diversity in diabetic polyneuropathy.Scholz J, Rathmell JP, David WS, Chad DA, Broderick AC, Perros SG, Shin NS, Wells JL, Davis JB, DiMaggio CJ, Wang S, Tate SN.157(10):2297-2308Painhttps://doi.org/10.1097/j.pain.000000000000064801/10/2016
27757418Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.Picaud, S; Leonards, K; Lambert, J-P; Dovey, O; Wells, C; Fedorov, O; Monteiro, O; Fujisawa, T; Wang, C-Y; Lingard, H; Tallant, C; Nikbin, N; Guetzoyan, L; Ingham, R; Ley, SV; Brennan, P; Muller, S; Samsonova, A; Gingras, A-C; Schwaller, J; Vassiliou, G; Knapp, S; Filippakopoulos, P; 2:e1600760-Science Advances10.1126/sciadv.160076012.10.2016
27520485Epigenetic blockade of neoplastic transformation by bromodomain and extra-terminal (BET) domain protein inhibitor JQ-1.Zhang, C; Su, Z-Y; Wang, L; Shu, L; Yang, Y; Guo, Y; Pung, D; Bountra, C; Kong, A-N; 117:35-45Biochemical Pharmacology10.1016/j.bcp.2016.08.00901.10.2016
27617704Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis.Myrianthopoulos, V; Gaboriaud-Kolar, N; Tallant, C; Hall, M-L; Grigoriou, S; Brownlee, PM; Fedorov, O; Rogers, C; Heidenreich, D; Wanior, M; Drosos, N; Mexia, N; Savitsky, P; Bagratuni, T; Kastritis, E; Terpos, E; Filippakopoulos, P; Müller, S; Skaltsounis, A-L; Downs, JA; Knapp, S; Mikros, E; 59:8787-8803Journal of Medicinal Chemistry10.1021/acs.jmedchem.6b0035501.10.2016
27673482Development of Selective CBP/P300 Benzoxazepine Bromodomain Inhibitors.Popp, TA; Tallant, C; Rogers, C; Fedorov, O; Brennan, PE; Müller, S; Knapp, S; Bracher, F; 59:8889-8912Journal of Medicinal Chemistry10.1021/acs.jmedchem.6b0077401.10.2016
27994766Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening.Navratilova, I; Aristotelous, T; Picaud, S; Chaikuad, A; Knapp, S; Filappakopoulos, P; Hopkins, AL; 7:1213-1218ACS Medicinal Chemistry Letters10.1021/acsmedchemlett.6b0015420.9.2016
27624942The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway.Carbonneau, M; M Gagné, L; Lalonde, M-E; Germain, M-A; Motorina, A; Guiot, M-C; Secco, B; Vincent, EE; Tumber, A; Hulea, L; Bergeman, J; Oppermann, U; Jones, RG; Laplante, M; Topisirovic, I; Petrecca, K; Huot, M-É; Mallette, FA; 7:12700-Nature Communications10.1038/ncomms1270014.9.2016
27759386Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product.Hughes SJ, Barnard L, Mottaghi K, Tempel W, Antoshchenko T, Hong BS, Allali-Hassani A, Smil D, Vedadi M, Strauss E, Park HW2(9):627-641ACS Infect Dis10.1021/acsinfecdis.6b0009009.09.2016
27595565Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1.Harrison JS, Cornett EM, Goldfarb D, DaRosa PA, Li ZM, Yan F, Dickson BM, Guo AH, Cantu DV, Kaustov L, Brown PJ, Arrowsmith CH, Erie DA, Major MB, Klevit RE, Krajewski K, Kuhlman B, Strahl BD, Rothbart SB5:Elife10.7554/eLife.1710107.09.2016
29170712Chemical probes and inhibitors of bromodomains outside the BET family.Moustakim, M; Clark, PGK; Hay, DA; Dixon, DJ; Brennan, PE; 7:2246-2264MedChemComm10.1039/c6md00373g01.12.2016
29170712Chemical probes and inhibitors of bromodomains outside the BET family.Moustakim, M; Clark, PGK; Hay, DA; Dixon, DJ; Brennan, PE; 7:2246-2264MedChemComm10.1039/c6md00373g01.12.2016
27604308Advantages and pitfalls of an extended gene panel for investigating complex neurometabolic phenotypes.Reid, ES; Papandreou, A; Drury, S; Boustred, C; Yue, WW; Wedatilake, Y; Beesley, C; Jacques, TS; Anderson, G; Abulhoul, L; Broomfield, A; Cleary, M; Grunewald, S; Varadkar, SM; Lench, N; Rahman, S; Gissen, P; Clayton, PT; Mills, PB; 139:2844-2854Brain10.1093/brain/aww22101.11.2016
27595404A proposal for validation of antibodies.Uhlen M, Bandrowski A, Carr S, Edwards A, Ellenberg J, Lundberg E, Rimm DL, Rodriguez H, Hiltke T, Snyder M, Yamamoto TNat. Methods10.1038/nmeth.399505.09.2016
A Multi-Crystal Method for Extracting Obscured Signal from Crystallographic Electron DensityPearce, N; Bradley, AR; Collins, P; Krojer, T; Nowak, R; Talon, R; Marsden, B; Kelm, S; Shi, J; Deane, C; von Delft, F; :-10.1101/0734115.9.2016
27584694Discovery of a Potent, Selective and Cell-active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6.Shen Y, Szewczyk MM, Eram MS, Smil D, Kaniskan HÜ, de Freitas RF, Senisterra G, Li F, Schapira M, Brown PJ, Arrowsmith CH, Barsyte-Lovejoy D, Liu J, Vedadi M, Jin JJ. Med. Chem.10.1021/acs.jmedchem.6b0103301.09.2016
27581605A Suite of Biochemical Assays for Screening RNA Methyltransferase BCDIN3D.Blazer LL, Li F, Kennedy S, Zheng YG, Arrowsmith CH, Vedadi MJ Biomol Screen10.1177/108705711666627631.08.2016
27571479Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors.Zhang, T; Kwiatkowski, N; Olson, CM; Dixon-Clarke, SE; Abraham, BJ; Greifenberg, AK; Ficarro, SB; Elkins, JM; Liang, Y; Hannett, NM; Manz, T; Hao, M; Bartkowiak, B; Greenleaf, AL; Marto, JA; Geyer, M; Bullock, AN; Young, RA; Gray, NS; 12:876-884Nature Chemical Biology10.1038/nchembio.216601.10.2016
27569753Chemical Inhibition of Protein Methyltransferases.Schapira MCell Chem Biol10.1016/j.chembiol.2016.07.01424.08.2016
27549117Structural Basis of Intracellular TGF-β Signaling: Receptors and Smads.Chaikuad, A; Bullock, AN; 8:-Cold Spring Harbor perspectives in biology10.1101/cshperspect.a02211101.11.2016
Enantioselective synthesis of a chemical probe for KDM2aGerken, P; Smith, M; Brennan, P; 252:-ACS National Meeting Book of Abstracts20.8.2016
27538024Structural biology: HDAC6 finally crystal clear.Liu Y, Li L, Min J12(9):660-1Nat. Chem. Biol.10.1038/nchembio.215818.08.2016
27532898Integration of Known DNA, RNA and Protein Biomarkers Provides Prediction of Anti-TNF Response in Rheumatoid Arthritis: Results from the COMBINE StudyFolkersen L, Brynedal B, Diaz-Gallo LM, Ramskold D, Shchetynsky K, Westerlind H, Sundstrom Y, Schepis D, Hensvold A, Vivar N, Eloranta ML, Ronnblom L, Brunak S, Malmstrom V, Catrina A, Moerch UGW, Klareskog L, Padyukov L, Berg L. 322-328Mol Med.10.2119/molmed.2016.0007815 Aug 2016
27519597A germline mutation of CDKN2A and a novel RPLP1-C19MC fusion detected in a rare melanotic neuroectodermal tumor of infancy: a case report.Barnes, DJ; Hookway, E; Athanasou, N; Kashima, T; Oppermann, U; Hughes, S; Swan, D; Lueerssen, D; Anson, J; Hassan, AB; 16:629-BMC Cancer10.1186/s12885-016-2669-312.8.2016
27512948Three-dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model.Maguire, SL; Peck, B; Wai, PT; Campbell, J; Barker, H; Gulati, A; Daley, F; Vyse, S; Huang, P; Lord, CJ; Farnie, G; Brennan, K; Natrajan, R; 240:315-328Journal of Pathology10.1002/path.477801.11.2016
27594912Accelerating target discovery using pre-competitive open science-patients need faster innovation more than anyone else.Low, E; Bountra, C; Lee, WH; 10:ed57-ecancermedicalscience10.3332/ecancer.2016.ed5701.1.2016
27480107Structural basis of arginine asymmetrical dimethylation by PRMT6.Wu H, Zheng W, Eram MS, Vhuiyan M, Dong A, Zeng H, He H, Brown P, Frankel A, Vedadi M, Luo M, Min JBiochem. J.10.1042/BCJ2016053701.08.2016
Natural killer (NK) cells and gamma delta T cells differentially modulate Th17-driven disease in ankylosing spondylitisWythe, S; Griseri, T; Freidin, A; Demetriou, P; Samson, S; Mccann, F; Horwood, N; 46:67-67European Journal of Immunology01.8.2016
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27478041Salt-Inducible Kinase 2 Couples Ovarian Cancer Cell Metabolism with Survival at the Adipocyte-Rich Metastatic Niche.Miranda, F; Mannion, D; Liu, S; Zheng, Y; Mangala, LS; Redondo, C; Herrero-Gonzalez, S; Xu, R; Taylor, C; Chedom, DF; Karaminejadranjbar, M; Albukhari, A; Jiang, D; Pradeep, S; Rodriguez-Aguayo, C; Lopez-Berestein, G; Salah, E; Abdul Azeez, KR; Elkins, JM; Campo, L; Myers, KA; Klotz, D; Bivona, S; Dhar, S; Bast, RC; Saya, H; Choi, HG; Gray, NS; Fischer, R; Kessler, BM; Yau, C; Sood, AK; Motohara, T; Knapp, S; Ahmed, AA; 30:273-289Cancer Cell10.1016/j.ccell.2016.06.02001.8.2016
Selective modulation of Natural Killer (NK) cell phenotypes through chromatin modifying mechanismsCribbs, A; Feldmann, M; Soderstrom, K; Oppermann, U; 46:68-69European Journal of Immunology01.8.2016
27468126Structure-Activity Relationship Studies for Enhancer of Zeste Homologue 2 (EZH2) and Enhancer of Zeste Homologue 1 (EZH1) Inhibitors.Yang X, Li F, Konze KD, Meslamani J, Ma A, Brown PJ, Zhou MM, Arrowsmith CH, Kaniskan HÜ, Vedadi M, Jin JJ. Med. Chem.10.1021/acs.jmedchem.6b0085528.07.2016
27485386New small molecule inhibitors of histone methyl transferase DOT1L with a nitrile as a non-traditional replacement for heavy halogen atoms.Spurr SS, Bayle ED, Yu W, Li F, Tempel W, Vedadi M, Schapira M, Fish PVBioorg. Med. Chem. Lett.10.1016/j.bmcl.2016.07.04121.07.2016
27403962Effect of BET Missense Mutations on Bromodomain Function, Inhibitor Binding and Stability.Lori, L; Pasquo, A; Lori, C; Petrosino, M; Chiaraluce, R; Tallant, C; Knapp, S; Consalvi, V; 11:e0159180-PLoS ONE10.1371/journal.pone.015918001.1.2016
27402533High resolution crystal structure of DPF3b in complex with an acetylated histone peptide.Li W, Zhao A, Tempel W, Loppnau P, Liu YJ. Struct. Biol.10.1016/j.jsb.2016.07.00108.07.2016
27390919Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening.Ferreira de Freitas R, Eram MS, Smil D, Szewczyk MM, Kennedy S, Brown PJ, Santhakumar V, Barsyte-Lovejoy D, Arrowsmith CH, Vedadi M, Schapira MJ. Med. Chem.10.1021/acs.jmedchem.6b0066808.07.2016
27388528H3K27me3 demethylases regulate in vitro chondrogenesis and chondrocyte activity in osteoarthritis.Yapp, C; Carr, AJ; Price, A; Oppermann, U; Snelling, SJB; 18:158-Arthritis Research10.1186/s13075-016-1053-77.7.2016
27213690CIS is a potent checkpoint in NK cell-mediated tumor immunity.Delconte, RB; Kolesnik, TB; Dagley, LF; Rautela, J; Shi, W; Putz, EM; Putz, EM; Stannard, K; Zhang, J-G; Teh, C; Firth, M; Ushiki, T; Andoniou, CE; Degli-Esposti, MA; Sharp, PP; Sanvitale, CE; Infusini, G; Liau, NPD; Linossi, EM; Burns, CJ; Carotta, S; Gray, DHD; Seillet, C; Hutchinson, DS; Belz, GT; Webb, AI; Alexander, WS; Li, SS; Bullock, AN; Babon, JJ; Smyth, MJ; Nicholson, SE; Huntington, ND; 17:816-824Nature Immunology10.1038/ni.347001.7.2016
27159579Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk.Sdelci, S; Lardeau, C-H; Tallant, C; Klepsch, F; Klaiber, B; Bennett, J; Rathert, P; Schuster, M; Penz, T; Fedorov, O; Superti-Furga, G; Bock, C; Zuber, J; Huber, KVM; Knapp, S; Müller, S; Kubicek, S; 12:504-510Nature Chemical Biology10.1038/nchembio.208001.7.2016
27325775Cardiac myosin light chain is phosphorylated by Ca2+/calmodulin-dependent and -independent kinase activities.Chang, AN; Mahajan, P; Knapp, S; Barton, H; Sweeney, HL; Kamm, KE; Stull, JT; 113:E3824-E3833Proceedings of the National Academy of Sciences01.7.2016
27367338Exploring the role of water in molecular recognition: predicting protein ligandability using a combinatorial search of surface hydration sites.Vukovic, S; Brennan, PE; Huggins, DJ; 28:344007-Journal of Physics: Condensed Matter10.1088/0953-8984/28/34/34400701.9.2016
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27259267BET inhibition as a new strategy for the treatment of gastric cancer.Montenegro, RC; Clark, PGK; Howarth, A; Wan, X; Ceroni, A; Siejka, P; Nunez-Alonso, GA; Monteiro, O; Rogers, C; Gamble, V; Burbano, R; Brennan, PE; Tallant, C; Ebner, D; Fedorov, O; O'Neill, E; Knapp, S; Dixon, D; Müller, S; 7:43997-44012Oncotarget10.18632/oncotarget.976601.7.2016
27240455From structural biology to designing therapy for inborn errors of metabolism.Yue, WW;39:489-498Journal of Inherited Metabolic Disease10.1007/s10545-016-9923-301.7.2016
27325560Mycolactone-mediated neurite degeneration and functional effects in cultured human and rat DRG neurons: Mechanisms underlying hypoalgesia in Buruli ulcer.Anand, U; Sinisi, M; Fox, M; MacQuillan, A; Quick, T; Korchev, Y; Bountra, C; McCarthy, T; Anand, P; 12:-Molecular Pain10.1177/174480691665414401.1.2016
27318562Methyltransferase inhibitors for modulation of the epigenome and beyond.Schapira M, Arrowsmith CH33:81-87Curr Opin Chem Biol10.1016/j.cbpa.2016.05.03016.06.2016
27288029Structure and function of histone methylation-binding proteins in plants.Liu Y, Min J473(12):1663-80Biochem. J.10.1042/BCJ2016012315.06.2016
27302065Mammalian Glucose Transporter Activity Is Dependent upon Anionic and Conical Phospholipids.Hresko, RC; Kraft, TE; Quigley, A; Carpenter, EP; Hruz, PW; 291:17271-17282Journal of Biological Chemistry10.1074/jbc.M116.73016801.8.2016
27294782Functional interdependence of BRD4 and DOT1L in MLL leukemia.Gilan O, Lam EY, Becher I, Lugo D, Cannizzaro E, Joberty G, Ward A, Wiese M, Fong CY, Ftouni S, Tyler D, Stanley K, MacPherson L, Weng CF, Chan YC, Ghisi M, Smil D, Carpenter C, Brown P, Garton N, Blewitt ME, Bannister AJ, Kouzarides T, Huntly BJ, Johnstone RW, Drewes G, Dawson SJ, Arrowsmith CH, Grandi P, Prinjha RK, Dawson MANat. Struct. Mol. Biol.10.1038/nsmb.324913.06.2016
27292644SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis.Elkouris M, Kontaki H, Stavropoulos A, Antonoglou A, Nikolaou KC, Samiotaki M, Szantai E, Saviolaki D, Brown PJ, Sideras P, Panayotou G, Talianidis ICell Rep10.1016/j.celrep.2016.05.05108.06.2016
27255711Structural Basis of the Recruitment of Ubiquitin-Specific Protease USP15 by Spliceosome Recycling Factor SART3.Zhang Q, Harding R, Hou F, Dong A, Walker JR, Bteich J, Tong YJ. Biol. Chem.10.1074/jbc.M116.74078702.06.2016
27219676Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors.Wang, Z; Bian, H; Bartual, SG; Du, W; Luo, J; Zhao, H; Zhang, S; Mo, C; Zhou, Y; Xu, Y; Tu, Z; Ren, X; Lu, X; Brekken, RA; Yao, L; Bullock, AN; Su, J; Ding, K; 59:5911-5916Journal of Medicinal Chemistry10.1021/acs.jmedchem.6b001403.6.2016
27241700Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.McClenaghan, C; Schewe, M; Aryal, P; Carpenter, EP; Baukrowitz, T; Tucker, SJ; 147:497-505Journal of General Physiology10.1085/jgp.20161160101.6.2016
Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritisMontgomery, AB; Kopec, J; Shrestha, L; Thezenas, M-L; Burgess-Brown, NA; Fischer, R; Yue, WW; Venables, PJ; 75:1255-1261Annals of the Rheumatic Diseases10.1136/annrheumdis-2015-20765601.6.2016
PRECLINICAL EFFICACY OF ALK2 INHIBITORS IN ACVR1 MUTANT DIPGCarvalho, D; Taylor, K; Olaciregui, NG; Valenti, M; Ruddle, R; Henley, A; Hayes, A; De Haven Brandon, A; Hallsworth, A; Mackay, A; Molinari, V; Vinci, M; Popov, S; Boudhar, A; Brennan, P; Moore, A; Hudson, L; Hoelder, S; Bullock, A; Raynaud, F; Eccles, S; Carcaboso, AM; Jones, C; 18:63-63Neuro-Oncology01.6.2016
26999302Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib.Mathea, S; Abdul Azeez, KR; Salah, E; Tallant, C; Wolfreys, F; Konietzny, R; Fischer, R; Lou, HJ; Brennan, PE; Schnapp, G; Pautsch, A; Kessler, BM; Turk, BE; Knapp, S; 11:1595-1602ACS Chemical Biology10.1021/acschembio.6b0004301.6.2016
27223324PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3.Chung HR, Xu C, Fuchs A, Mund A, Lange M, Staege H, Schubert T, Bian C, Dunkel I, Eberharter A, Regnard C, Klinker H, Meierhofer D, Cozzuto L, Winterpacht A, DiCroce L, Min J, Will H, Kinkley S5:Elife10.7554/eLife.1060725.05.2016
27219844Protein-Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery.Milhas, S; Raux, B; Betzi, S; Derviaux, C; Roche, P; Restouin, A; Basse, M-J; Rebuffet, E; Lugari, A; Badol, M; Kashyap, R; Lissitzky, J-C; Eydoux, C; Hamon, V; Gourdel, M-E; Combes, S; Zimmermann, P; Aurrand-Lions, M; Roux, T; Rogers, C; Müller, S; Knapp, S; Trinquet, E; Collette, Y; Guillemot, J-C; Morelli, X; 11:2140-2148ACS Chemical Biology10.1021/acschembio.6b0028601.8.2016
27214403Structural analysis of human KDM5B guides histone demethylase inhibitor developmentJohansson, C; Velupillai, S; Tumber, A; Szykowska, A; Hookway, ES; Nowak, RP; Strain-Damerell, C; Gileadi, C; Philpott, M; Burgess-Brown, N; Wu, N; Kopec, J; Nuzzi, A; Steuber, H; Egner, U; Badock, V; Munro, S; LaThangue, NB; Westaway, S; Brown, J; Athanasou, N; Prinjha, R; Brennan, PE; Oppermann, U; 12:539-545Nature Chemical Biology10.1038/nchembio.208701.7.2016
27167397Perspective: Science is still too closed.Edwards A533:S70Nature10.1038/533S70a12.05.2016
27163177An Integrative Proteomic Approach Identifies Novel Cellular SMYD2 Substrates.Ahmed H, Duan S, Arrowsmith CH, Barsyte-Lovejoy D, Schapira MJ. Proteome Res.10.1021/acs.jproteome.6b0022010.05.2016
27149119Global Profiling of Acetyltransferase Feedback Regulation.Montgomery DC, Garlick J, Kulkarni RA, Kennedy S, Allali-Hassani A, Kuo YM, Andrews AJ, Wu H, Vedadi M, Meier JLJ. Am. Chem. Soc.10.1021/jacs.6b0303605.05.2016
Regulatory barriers to the advancement of precision medicinePettitt, D; Smith, J; Meadows, N; Arshad, Z; Schuh, A; DiGiusto, D; Bountra, C; Holländer, G; Barker, R; Brindley, D; 1:319-329Expert Review of Precision Medicine and Drug Development10.1080/23808993.2016.11765263.5.2016
27119626Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex.Sutherell, CL; Tallant, C; Monteiro, OP; Yapp, C; Fuchs, JE; Fedorov, O; Siejka, P; Müller, S; Knapp, S; Brenton, JD; Brennan, PE; Ley, SV; 59:5095-5101Journal of Medicinal Chemistry10.1021/acs.jmedchem.5b0199711.5.2016
27139824Co-crystal structures of the protein kinase haspin with bisubstrate inhibitors.Lavogina, D; Kestav, K; Chaikuad, A; Heroven, C; Knapp, S; Uri, A; 72:339-345Acta Crystallographica Section F: Structural Biology Communications10.1107/S2053230X1600461101.5.2016
27121860Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo.Lee, SY; Brem, J; Pettinati, I; Claridge, TDW; Gileadi, O; Schofield, CJ; McHugh, PJ; 52:6727-6730Chemical Communications10.1039/c6cc00529b01.5.2016
26933036Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca2+ Signalling.Sidik SM, Hortua Triana MA, Paul AS, El Bakkouri M, Hackett CG, Tran F, Westwood NJ, Hui R, Zuercher WJ, Duraisingh MT, Moreno SN, Lourido SJ. Biol. Chem.10.1074/jbc.M115.70354629.04.2016
27129774PR Domain-Containing Protein 7 (PRDM7) is a Histone 3 Lysine 4 Trimethyltransferase.Blazer LL, Lima-Fernandes E, Gibson E, Eram MS, Loppnau P, Arrowsmith CH, Schapira M, Vedadi MJ. Biol. Chem.10.1074/jbc.M116.72147229.04.2016
27115555Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit.Gerstenberger, BS; Trzupek, JD; Tallant, C; Fedorov, O; Filippakopoulos, P; Brennan, PE; Fedele, V; Martin, S; Picaud, S; Rogers, C; Parikh, M; Taylor, A; Samas, B; O'Mahony, A; Berg, E; Pallares, G; Torrey, AD; Treiber, DK; Samardjiev, IJ; Nasipak, BT; Padilla-Benavides, T; Wu, Q; Imbalzano, AN; Nickerson, JA; Bunnage, ME; Müller, S; Knapp, S; Owen, DR; 59:4800-4811Journal of Medicinal Chemistry10.1021/acs.jmedchem.6b000123.5.2016
26929408Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation.Habisov S, Huber J, Ichimura Y, Akutsu M, Rogova N, Loehr F, McEwan DG, Johansen T, Dikic I, Doetsch V, Komatsu M, Rogov VV, Kirkin V.291(17):9025-41J Biol Chem10.1074/jbc.M116.71547422.04.2016
27075367Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2.Eggert E, Hillig RC, Köhr S, Stöckigt D, Weiske J, Barak N, Mowat J, Brumby T, Christ CD, Ter Laak A, Lang T, Fernández-Montalván AE, Badock V, Weinmann H, Hartung IV, Barsyte-Lovejoy D, Szewczyk M, Kennedy S, Li F, Vedadi M, Brown PJ, Santhakumar V, Arrowsmith CH, Stellfeld T, Stresemann CJ. Med. Chem.10.1021/acs.jmedchem.5b0189013.04.2016
27035970Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria.Richter B, Sliter DA, Herhaus L, Stolz A, Wang C, Beli P, Zaffagnini G, Wild P, Martens S, Wagner SA, Youle RJ, Dikic I.113(15):4039-44Proc Natl Acad Sci U S A10.1073/pnas.152392611312.04.2016
27049649Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain.Patel, D; Kopec, J; Fitzpatrick, F; McCorvie, TJ; Yue, WW; 6:23748-Scientific Reports10.1038/srep237486.4.2016
27050687Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop.Adams PD, Aertgeerts K, Bauer C, Bell JA, Berman HM, Bhat TN, Blaney JM, Bolton E, Bricogne G, Brown D, Burley SK, Case DA, Clark KL, Darden T, Emsley P, Feher VA, Feng Z, Groom CR, Harris SF, Hendle J, Holder T, Joachimiak A, Kleywegt GJ, Krojer T, Marcotrigiano J, Mark AE, Markley JL, Miller M, Minor W, Montelione GT, Murshudov G, Nakagawa A, Nakamura H, Nicholls A, Nicklaus M, Nolte RT, Padyana AK, Peishoff CE, Pieniazek S, Read RJ, Shao C, Sheriff S, Smart O, Soisson S, Spurlino J, Stouch T, Svobodova R, Tempel W, Terwilliger TC, Tronrud D, Velankar S, Ward SC, Warren GL, Westbrook JD, Williams P, Yang H, Young J24(4):502-8Structure10.1016/j.str.2016.02.01705.04.2016
27128181Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure.Esvan, YJ; Zeinyeh, W; Boibessot, T; Nauton, L; Théry, V; Knapp, S; Chaikuad, A; Loaëc, N; Meijer, L; Anizon, F; Giraud, F; Moreau, P; 118:170-177European Journal of Medicinal Chemistry5.4.2016
27046831SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling.Oudhoff MJ, Braam MJ, Freeman SA, Wong D, Rattray DG, Wang J, Antignano F, Snyder K, Refaeli I, Hughes MR, McNagny KM, Gold MR, Arrowsmith CH, Sato T, Rossi FM, Tatlock JH, Owen DR, Brown PJ, Zaph C37(1):47-57Dev. Cell10.1016/j.devcel.2016.03.00204.04.2016
27161699PO-11 - Thrombin and cancer stem-like cells: in vitro support for breast cancer anticoagulation.Castle, J; Farnie, G; Kirwan, CC; :-Thrombosis Research8.4.2016
27021569Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level.Coutandin, D; Osterburg, C; Srivastav, RK; Sumyk, M; Kehrloesser, S; Gebel, J; Tuppi, M; Hannewald, J; Schäfer, B; Salah, E; Mathea, S; Müller-Kuller, U; Doutch, J; Grez, M; Knapp, S; Dötsch, V; 5:-eLife10.7554/eLife.1390914.3.2016
27005423Molecular basis of classic galactosemia from the structure of human galactose 1-phosphate uridylyltransferase.McCorvie, TJ; Kopec, J; Pey, AL; Fitzpatrick, F; Patel, D; Chalk, R; Shrestha, L; Yue, WW; 25:2234-2244Human Molecular Genetics10.1093/hmg/ddw09101.6.2016
26983524Reproducibility: Team up with industry.Edwards A531(7594):299-301Nature10.1038/531299a17.03.2016
26983878Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells.Tögel, L; Nightingale, R; Chueh, AC; Jayachandran, A; Tran, H; Phesse, T; Wu, R; Sieber, OM; Arango, D; Dhillon, AS; Dawson, MA; Diez-Dacal, B; Gahman, TC; Filippakopoulos, P; Shiau, AK; Mariadason, JM; 15:1217-1226Molecular Cancer Therapeutics10.1158/1535-7163.mct-15-072401.6.2016
Design and utilisation of a poised fragment library in the search for inhibitors of PHIP(2), an atypical bromodomainCox, O; Spencer, J; Brennan, P; 251:-ACS National Meeting Book of Abstracts13.3.2016
27379343Identification of small molecule inhibitors that block the Toxoplasma gondii rhoptry kinase ROP18.Simpson C, Jones NG, Hull-Ryde EA, Kireev D, Stashko M, Tang K, Janetka J, Wildman SA, Zuercher WJ, Schapira M, Hui R, Janzen W, Sibley LD2(3):194-206ACS Infect Dis10.1021/acsinfecdis.5b0010211.03.2016
26914985Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor.Martin, LJ; Koegl, M; Bader, G; Cockcroft, X-L; Fedorov, O; Fiegen, D; Gerstberger, T; Hofmann, MH; Hohmann, AF; Kessler, D; Knapp, S; Knesl, P; Kornigg, S; Müller, S; Nar, H; Rogers, C; Rumpel, K; Schaaf, O; Steurer, S; Tallant, C; Vakoc, CR; Zeeb, M; Zoephel, A; Pearson, M; Boehmelt, G; McConnell, D; 59:4462-4475Journal of Medicinal Chemistry10.1021/acs.jmedchem.5b0186501.5.2016
26958703Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1).Getlik M, Smil D, Zepeda-Velázquez C, Bolshan Y, Poda G, Wu H, Dong A, Kuznetsova E, Marcellus R, Senisterra G, Dombrovski L, Hajian T, Kiyota T, Schapira M, Arrowsmith CH, Brown PJ, Vedadi M, Al-Awar RJ. Med. Chem.10.1021/acs.jmedchem.5b0163009.03.2016
26934697Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds.Crowther GJ, Hillesland HK, Keyloun KR, Reid MC, Lafuente-Monasterio MJ, Ghidelli-Disse S, Leonard SE, He P, Jones JC, Krahn MM, Mo JS, Dasari KS, Fox AM, Boesche M, El Bakkouri M, Rivas KL, Leroy D, Hui R, Drewes G, Maly DJ, Van Voorhis WC, Ojo KK11(3):e0149996PLoS ONE10.1371/journal.pone.014999602.03.2016
26949039System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.Zhang W, Wu KP, Sartori MA, Kamadurai HB, Ordureau A, Jiang C, Mercredi PY, Murchie R, Hu J, Persaud A, Mukherjee M, Li N, Doye A, Walker JR, Sheng Y, Hao Z, Li Y, Brown KR, Lemichez E, Chen J, Tong Y, Harper JW, Moffat J, Rotin D, Schulman BA, Sidhu SSMol. Cell10.1016/j.molcel.2016.02.00502.03.2016
26933034Family-wide characterization of histone binding abilities of human CW domain containing proteins.Liu Y, Tempel W, Zhang Q, Liang X, Loppnau P, Qin S, Min JJ. Biol. Chem.10.1074/jbc.M116.71897301.03.2016
29910922A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain.Cox, OB; Krojer, T; Collins, P; Monteiro, O; Talon, R; Bradley, A; Fedorov, O; Amin, J; Marsden, BD; Spencer, J; von Delft, F; Brennan, PE; 7:2322-2330Chemical Science10.1039/c5sc03115j01.3.2016
27769361Development of chemical probes for the bromodomains of BRD7 and BRD9.Clark, PGK; Dixon, DJ; Brennan, PE; 19:73-80Drug Discovery Today: Technologies10.1016/j.ddtec.2016.05.00201.3.2016
26906419Ubiquitin chain diversity at a glance.Akutsu M, Dikic I, Bremm A.129(5):875-80J Cell Sci10.1242/jcs.18395401.03.2016
Characterization of NK Cells in Endometriosis Associated Pain.Soderstrom, K; Southcombe, J; Malzahn, J; Putsep, L; Oppermann, U; Shang, C; Becker, C; Zondervan, K; Martin-Fischer, O; Zollner, TM; Granne, I; Sacher, F; 23:161A-161AReproductive Sciences01.3.2016
26960118An overview of heavy-atom derivatization of protein crystals.Pike, ACW; Garman, EF; Krojer, T; von Delft, F; Carpenter, EP; 72:303-318Acta Crystallographica. Section d, Structural Biology10.1107/S205979831600040101.3.2016
26929412Structural Basis for Substrate Preference of SMYD3, A SET Domain-containing Protein Lysine Methyltransferase.Fu W, Liu N, Qiao Q, Wang M, Min J, Zhu B, Xu RM, Yang NJ. Biol. Chem.10.1074/jbc.M115.70983229.02.2016
26919541Structural basis for a novel interaction between TXNIP and Vav2.Liu S, Wu X, Zong M, Tempel W, Loppnau P, Liu YFEBS Lett.10.1002/1873-3468.1211025.02.2016
26896083Sclerostin expression in bone tumours and tumour-like lesions.Inagaki, Y; Hookway, ES; Kashima, TG; Munemoto, M; Tanaka, Y; Hassan, AB; Oppermann, U; Athanasou, NA; 69:470-478Histopathology10.1111/his.1295320.2.2016
26893353Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform.Wagner, T; Greschik, H; Burgahn, T; Schmidtkunz, K; Schott, A-K; McMillan, J; Baranauskienė, L; Xiong, Y; Fedorov, O; Jin, J; Oppermann, U; Matulis, D; Schüle, R; Jung, M; 44:e88-Nucleic Acids Research10.1093/nar/gkw08901.5.2016
Predicting Ligand Selectivity Across Bromodomain FamiliesAldeghi, M; Heifetz, A; Bodkin, MJ; Knapp, S; Biggin, PC; 110:545A-545ABiophysical Journal10.1016/j.bpj.2015.11.291516.2.2016
27423858Chemical Biology Approaches for Characterization of Epigenetic Regulators.Barsyte-Lovejoy D, Szewczyk MM, Prinos P, Lima-Fernandes E, Ackloo S, Arrowsmith CH574:79-103Meth. Enzymol.10.1016/bs.mie.2016.01.01116.02.2016
Conformational Plasticity of the MAGE-A3 Protein as a Therapeutic Strategy in Multiple MyelomaOsman, R; Cho, HJ; Mei, AH; Newman, JA; Gileadi, O; 110:535A-535ABiophysical Journal10.1016/j.bpj.2015.11.286216.2.2016
26878383Apollo-NADP(+): a spectrally tunable family of genetically encoded sensors for NADP(.)Cameron WD, Bui CV, Hutchinson A, Loppnau P, Gräslund S, Rocheleau JVNat. Methods10.1038/nmeth.376415.02.2016
26989780Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response.Ghari, F; Quirke, A-M; Munro, S; Kawalkowska, J; Picaud, S; McGouran, J; Subramanian, V; Muth, A; Williams, R; Kessler, B; Thompson, PR; Fillipakopoulos, P; Knapp, S; Knapp, S; Venables, PJ; La Thangue, NB; 2:e1501257-Science Advances10.1126/sciadv.15012575.2.2016
26710088Recent Progress in Histone Demethylase Inhibitors.McAllister, TE; England, KS; Hopkinson, RJ; Brennan, PE; Kawamura, A; Schofield, CJ; 59:1308-1329Journal of Medicinal Chemistry10.1021/acs.jmedchem.5b017582.2.2016
26894670Lessons from ten years of crystallization experiments at the SGC.Ng, JT; Dekker, C; Reardon, P; von Delft, F; 72:224-235Acta Crystallographica. Section d, Structural Biology10.1107/S205979831502468701.2.2016
First insights into the action of the carbazole derivative C81 and the role of its primary target BMP2K in the activated vascular endotheliumBischoff, I; Dai, B; Stroedke, B; Knapp, S; Bracher, F; Fuerst, R; 389:S6-S6Naunyn-Schmiedeberg's Archives of Pharmacology01.2.2016
FORMATION OF NOVEL CITRULLINATED PEPTIDES BY PORPHYROMONASGINGIVALIS PAD ENZYME: IMPLICATIONS FOR AUTOIMMUNITY IN RHEUMATOID ARTHRITISMontgomery, AB; Kopec, J; Shrestha, L; Schewenzer, A; Correia, RE; Fischer, R; Burgess-Brown, N; Yue, WW; Venables, PJ; 75:A33-A33Annals of the Rheumatic Diseases10.1136/annrheumdis-2016-209124.8001.2.2016
26910052Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding.Newman, JA; Cooper, CDO; Roos, AK; Aitkenhead, H; Oppermann, UCT; Cho, HJ; Osman, R; Gileadi, O; 11:e0148762-PLoS ONE10.1371/journal.pone.014876201.1.2016
26853940Family-wide Structural Analysis of Human Numb-Associated Protein Kinases.Sorrell, FJ; Szklarz, M; Abdul Azeez, KR; Elkins, JM; Knapp, S; 24:401-411Structure10.1016/j.str.2015.12.01501.3.2016
26826708Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease.Levy, S; Allerston, CK; Liveanu, V; Habib, MR; Gileadi, O; Schuster, G; 44:1813-1832Nucleic Acids Research10.1093/nar/gkw05001.2.2016
26824386Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor.Ferreira de Freitas R, Eram MS, Szewczyk MM, Steuber H, Smil D, Wu H, Li F, Senisterra G, Dong A, Brown PJ, Hitchcock M, Moosmayer D, Stegmann CM, Egner U, Arrowsmith C, Barsyte-Lovejoy D, Vedadi M, Schapira MJ. Med. Chem.10.1021/acs.jmedchem.5b0177229.01.2016
26821065Deciphering the true antiproliferative target of an MK2 activation inhibitor in glioblastoma.Brennan, PE;7:e2069-Cell Death and Disease10.1038/cddis.2015.38428.1.2016
26804164Epigenomic regulation of oncogenesis by chromatin remodeling.Kumar, R; Li, D-Q; Müller, S; Knapp, S; 35:4423-4436Oncogene10.1038/onc.2015.51301.8.2016
26807715A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1.Stuckey JI, Dickson BM, Cheng N, Liu Y, Norris JL, Cholensky SH, Tempel W, Qin S, Huber KG, Sagum C, Black K, Li F, Huang XP, Roth BL, Baughman BM, Senisterra G, Pattenden SG, Vedadi M, Brown PJ, Bedford MT, Min J, Arrowsmith CH, James LI, Frye SVNat. Chem. Biol.10.1038/nchembio.200725.01.2016
26807646EXD2 promotes homologous recombination by facilitating DNA end resection.Broderick, R; Nieminuszczy, J; Baddock, HT; Deshpande, R; Gileadi, O; Paull, TT; McHugh, PJ; Niedzwiedz, W; 18:271-280Nature Cell Biology10.1038/ncb330301.3.2016
26933743The Intersection of Structural and Chemical Biology - An Essential Synergy.Zuercher, WJ; Elkins, JM; Knapp, S; 23:173-182Cell Chemical Biology10.1016/j.chembiol.2015.12.00501.1.2016
26791045Open Access Could Transform Drug Discovery: A Case Study of JQ1.Arshad, Z; Smith, J; Roberts, M; Lee, WH; Davies, B; Bure, K; Hollander, GA; Dopson, S; Bountra, C; Brindley, D; 11:321-332Expert Opinion on Drug Discovery10.1517/17460441.2016.114458701.1.2016
26798447Accurate calculation of the absolute free energy of binding for drug molecules.Aldeghi, M; Heifetz, A; Bodkin, MJ; Knapp, S; Biggin, PC; 7:207-218Chemical Science10.1039/c5sc02678d01.1.2016
26731131Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain.Chaikuad, A; Lang, S; Brennan, PE; Temperini, C; Fedorov, O; Hollander, J; Nachane, R; Abell, C; Müller, S; Siegal, G; Knapp, S; 59:1648-1653Journal of Medicinal Chemistry10.1021/acs.jmedchem.5b0171901.2.2016
267411688-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.Bavetsias, V; Lanigan, RM; Ruda, GF; Atrash, B; McLaughlin, MG; Tumber, A; Mok, NY; Le Bihan, Y-V; Dempster, S; Boxall, KJ; Jeganathan, F; Hatch, SB; Savitsky, P; Velupillai, S; Krojer, T; England, KS; Sejberg, J; Thai, C; Donovan, A; Pal, A; Scozzafava, G; Bennett, JM; Kawamura, A; Johansson, C; Szykowska, A; Gileadi, C; Burgess-Brown, NA; von Delft, F; Oppermann, U; Walters, Z; Shipley, J; Raynaud, FI; Westaway, SM; Prinjha, RK; Fedorov, O; Burke, R; Schofield, CJ; Westwood, IM; Bountra, C; Müller, S; van Montfort, RLM; Brennan, PE; Blagg, J; 59:1388-1409Journal of Medicinal Chemistry10.1021/acs.jmedchem.5b0163501.2.2016
26584204Dye-sensitised semiconductors modified with molecular catalysts for light-driven H2 production.Willkomm, J; Orchard, KL; Reynal, A; Pastor, E; Durrant, JR; Reisner, E; 45:9-23Chemical Society Reviews10.1039/c5cs00733j01.1.2016
26755663Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target.Agarwal P, Alzrigat M, Párraga AA, Enroth S, Singh U, Ungerstedt J, Österborg A, Brown PJ, Ma A, Jin J, Nilsson K, Öberg F, Kalushkova A, Jernberg-Wiklund HOncotarget10.18632/oncotarget.684307.01.2016
8‐Substituted Pyrido[3,4‐d]pyrimidin-4(3H)‐one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase InhibitorsBavetsias, V; Lanigan, R; Ruda, G; Oppermann, U; :-10.1021/acs.jmedchem.5b016357.1.2016
26735842Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins.Raux, B; Voitovich, Y; Derviaux, C; Lugari, A; Rebuffet, E; Milhas, S; Priet, S; Roux, T; Trinquet, E; Guillemot, J-C; Knapp, S; Brunel, J-M; Fedorov, AY; Collette, Y; Roche, P; Betzi, S; Combes, S; Morelli, X; 59:1634-1641Journal of Medicinal Chemistry10.1021/acs.jmedchem.5b0170801.2.2016
Novel p38 alpha MAP kinase inhibitors identified from yoctoReactor DNA-encoded small molecule libraryPetersen, LK; Blakskjaer, P; Chaikuad, A; Christensen, AB; Dietvorst, J; Holmkvist, J; Knapp, S; Korinek, M; Larsen, LK; Pedersen, AE; Roehm, S; Slok, FA; Hansen, NJV; 7:1332-1339MedChemComm10.1039/c6md00241b01.01.2016
26700051Profiling of Small Molecules by Chemical Proteomics.Huber, KVM; Superti-Furga, G; 1394:211-218Methods in Molecular Biology10.1007/978-1-4939-3341-9_1501.1.2016
26803640Investigating the Role of Toll-Like Receptors in Models of Arthritis.Piccinini, AM; Williams, L; McCann, FE; Midwood, KS; 1390:351-381Methods in Molecular Biology10.1007/978-1-4939-3335-8_2201.1.2016
26716911Use of Methylmalonyl-CoA Epimerase in Enhancing Crotonase Stereoselectivity.Hamed, RB; Gomez-Castellanos, JR; Sean Froese, D; Krysztofinska, E; Yue, WW; Schofield, CJ; 17:471-473ChemBioChem10.1002/cbic.20150064401.3.2016
26699912Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors.Korczynska, M; Le, DD; Younger, N; Gregori-Puigjané, E; Tumber, A; Krojer, T; Velupillai, S; Gileadi, C; Nowak, RP; Iwasa, E; Pollock, SB; Ortiz Torres, I; Oppermann, U; Shoichet, BK; Fujimori, DG; 59:1580-1598Journal of Medicinal Chemistry10.1021/acs.jmedchem.5b0152701.2.2016
26748598Role of reverse phenotyping in interpretation of next generation sequencing data and a review of INPP5E related disorders.de Goede, C; Yue, WW; Yan, G; Ariyaratnam, S; Chandler, KE; Downes, L; Khan, N; Mohan, M; Lowe, M; Banka, S; 20:286-295European Journal of Paediatric Neurology10.1016/j.ejpn.2015.11.01201.3.2016
26552403Emerging Target Families: Intractable Targets.K, S; n, ; a, ; p, ; p, ; 232:43-58Handbook of Experimental Pharmacology10.1007/164_2015_2801.1.2016
26501955Comprehensive characterization of the Published Kinase Inhibitor Set.Elkins, JM; Fedele, V; Szklarz, M; Abdul Azeez, KR; Salah, E; Mikolajczyk, J; Romanov, S; Sepetov, N; Huang, X-P; Roth, BL; Al Haj Zen, A; Fourches, D; Muratov, E; Tropsha, A; Morris, J; Teicher, BA; Kunkel, M; Polley, E; Lackey, KE; Atkinson, FL; Overington, JP; Bamborough, P; Müller, S; Price, DJ; Willson, TM; Drewry, DH; Knapp, S; Zuercher, WJ; 34:95-103Nature Biotechnology10.1038/nbt.337401.1.2016
26482303Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers.Brem, J; van Berkel, SS; Zollman, D; Lee, SY; Gileadi, O; McHugh, PJ; Walsh, TR; McDonough, MA; Schofield, CJ; 60:142-150Antimicrobial Agents and Chemotherapy10.1128/AAC.01335-1501.1.2016
26459632Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells.Morozumi, Y; Boussouar, F; Tan, M; Chaikuad, A; Jamshidikia, M; Colak, G; He, H; Nie, L; Petosa, C; de Dieuleveult, M; Curtet, S; Vitte, A-L; Rabatel, C; Debernardi, A; Cosset, F-L; Verhoeyen, E; Emadali, A; Schweifer, N; Gianni, D; Gut, M; Guardiola, P; Rousseaux, S; Gérard, M; Knapp, S; Zhao, Y; Khochbin, S; 8:349-362Journal of Molecular Cell Biology10.1093/jmcb/mjv06001.8.2016
26348019Mutations in Known Monogenic High Bone Mass Loci Only Explain a Small Proportion of High Bone Mass Cases.Gregson, CL; Wheeler, L; Hardcastle, SA; Appleton, LH; Addison, KA; Brugmans, M; Clark, GR; Ward, KA; Paggiosi, M; Stone, M; Thomas, J; Agarwal, R; Poole, KES; McCloskey, E; Fraser, WD; Williams, E; Bullock, AN; Davey Smith, G; Brown, MA; Tobias, JH; Duncan, EL; 31:640-649Journal of Bone and Mineral Research10.1002/jbmr.270601.3.2016
26209657Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis.Montgomery, AB; Kopec, J; Shrestha, L; Thezenas, M-L; Burgess-Brown, NA; Fischer, R; Yue, WW; Venables, PJ; 75:1255-1261Annals of the Rheumatic Diseases10.1136/annrheumdis-2015-20765601.6.2016
25974391Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF.Bennett, J; Fedorov, O; Tallant, C; Monteiro, O; Meier, J; Gamble, V; Savitsky, P; Nunez-Alonso, GA; Haendler, B; Rogers, C; Brennan, PE; Müller, S; Knapp, S; 59:1642-1647Journal of Medicinal Chemistry10.1021/acs.jmedchem.5b0045801.2.2016
25799074Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.Chen, P; Chaikuad, A; Bamborough, P; Bantscheff, M; Bountra, C; Chung, C-W; Fedorov, O; Grandi, P; Jung, D; Lesniak, R; Lindon, M; Müller, S; Philpott, M; Prinjha, R; Rogers, C; Selenski, C; Tallant, C; Werner, T; Willson, TM; Knapp, S; Drewry, DH; 59:1410-1424Journal of Medicinal Chemistry10.1021/acs.jmedchem.5b0020901.2.2016
Identification of small molecule inhibitors that block the Toxoplasma gondii rhoptry kinase ROP18Simpson C, Jones N, Hull-Ryde E, Kireev D, Stashko M, Tang K, Janetka J, Wildman S, Zuercher W, Schapira M, Hui R, Janzen W, Sibley LD.2(3):194-206ACS Infect. Dis.10.1021/acsinfecdis.5b0010228.12.2015
26701100A Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5.Li F, Kennedy S, Hajian T, Gibson E, Seitova A, Xu C, Arrowsmith CH, Vedadi MJ Biomol Screen10.1177/108705711562326423.12.2015
26700805SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination.Yanling Zhao D, Gish G, Braunschweig U, Li Y, Ni Z, Schmitges FW, Zhong G, Liu K, Li W, Moffat J, Vedadi M, Min J, Pawson TJ, Blencowe BJ, Greenblatt JFNature10.1038/nature1646923.12.2015
26483544Structural Insights into the MMACHC-MMADHC Protein Complex Involved in Vitamin B12 Trafficking.Froese, DS; Kopec, J; Fitzpatrick, F; Schuller, M; McCorvie, TJ; Chalk, R; Plessl, T; Fettelschoss, V; Fowler, B; Baumgartner, MR; Yue, WW; 290:29167-29177Journal of Biological Chemistry10.1074/jbc.M115.68326801.12.2015
26552700Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy.Picaud, S; Fedorov, O; Thanasopoulou, A; Leonards, K; Jones, K; Meier, J; Olzscha, H; Monteiro, O; Martin, S; Philpott, M; Tumber, A; Filippakopoulos, P; Yapp, C; Wells, C; Che, KH; Bannister, A; Robson, S; Kumar, U; Parr, N; Lee, K; Lugo, D; Jeffrey, P; Taylor, S; Vecellio, ML; Bountra, C; Brennan, PE; O'Mahony, A; Velichko, S; Müller, S; Hay, D; Daniels, DL; Urh, M; La Thangue, NB; Kouzarides, T; Prinjha, R; Schwaller, J; Knapp, S; 75:5106-5119Cancer Research10.1158/0008-5472.CAN-15-023601.12.2015
Decision-support tools for monoclonal antibody and cell therapy bioprocessing: Current landscape and development opportunitiesRekhi, R; Smith, JA; Arshad, Z; Roberts, M; Bountra, C; Bingham, I; Bure, K; Brindley, DA; 13:-BioProcess international1.12.2015
26636256Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.Newman, JA; Cooper, CDO; Aitkenhead, H; Gileadi, O; 23:2319-2330Structure10.1016/j.str.2015.10.01401.12.2015
26603348Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies.Davydov R, Strushkevich N, Smil D, Yantsevich A, Gilep A, Usanov S, Hoffman BMBiochemistry10.1021/acs.biochem.5b0090325.11.2015
26626085MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin.Gallo M, Coutinho FJ, Vanner RJ, Gayden T, Mack SC, Murison A, Remke M, Li R, Takayama N, Desai K, Lee L, Lan X, Park NI, Barsyte-Lovejoy D, Smil D, Sturm D, Kushida MM, Head R, Cusimano MD, Bernstein M, Clarke ID, Dick JE, Pfister SM, Rich JN, Arrowsmith CH, Taylor MD, Jabado N, Bazett-Jones DP, Lupien M, Dirks PBCancer Cell10.1016/j.ccell.2015.10.00525.11.2015
26598975A Potent, Selective and Cell-active Inhibitor of Human Type I Protein Arginine Methyltransferases.Eram MS, Shen Y, Szewczyk M, Wu H, Senisterra G, Li F, Butler KV, Kaniskan HÜ, Speed BA, Dela Seña C, Dong A, Zeng H, Schapira M, Brown PJ, Arrowsmith CH, Barsyte-Lovejoy D, Liu J, Vedadi M, Jin JACS Chem. Biol.10.1021/acschembio.5b0083924.11.2015
26597175Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding.Dixon-Clarke, SE; Elkins, JM; Cheng, S-WG; Morin, GB; Bullock, AN; 5:17122-Scientific Reports10.1038/srep1712224.11.2015
26578293Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins.Kamps JJ, Huang J, Poater J, Xu C, Pieters BJ, Dong A, Min J, Sherman W, Beuming T, Matthias Bickelhaupt F, Li H, Mecinović J6:8911Nat Commun10.1038/ncomms991119.11.2015
26582912The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities.Allerston, CK; Lee, SY; Newman, JA; Schofield, CJ; McHugh, PJ; Gileadi, O; 43:11047-11060Nucleic Acids Research10.1093/nar/gkv125601.12.2015
Regulation of signaling interactomes in cancerLambert, J-P; Zhou, Y; Couzens, A; Tsou, C-C; Picaud, S; Ivosev, G; Tate, S; Nesvizhskii, A; Filippakopoulos, P; Gingras, A-C; 75:-Cancer Research10.1158/1538-7445.COMPSYSBIO-IA1915.11.2015
26566070Structural Chemistry of Human RNA Methyltransferases.Schapira MACS Chem. Biol.10.1021/acschembio.5b0078113.11.2015
26541578Design of a fluorescent ligand targeting the S-adenosylmethionine binding site of the histone methyltransferase MLL1.Luan Y, Blazer LL, Hu H, Hajian T, Zhang J, Wu H, Houliston S, Arrowsmith CH, Vedadi M, Zheng YGOrg. Biomol. Chem.10.1039/c5ob01794g06.11.2015
PIM kinase-responsive microsecond-lifetime photoluminescent probes based on selenium-containing heteroaromatic tricycleEkambaram, R; Manoharan, GB; Enkvist, E; Ligi, K; Knapp, S; Uri, A; 5:96750-96757RSC Advances10.1039/c5ra20777k01.01.2015
26543161Structural basis for substrate recognition by the human N-terminal methyltransferase 1.Dong C, Mao Y, Tempel W, Qin S, Li L, Loppnau P, Huang R, Min JGenes Dev.10.1101/gad.270611.11505.11.2015
26527736Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP.Liu Y, Lau J, Li W, Tempel W, Li L, Dong A, Narula A, Qin S, Min JBiochem. J.10.1042/BJ2015083002.11.2015
26702435Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.Fedorov, O; Castex, J; Tallant, C; Owen, DR; Martin, S; Aldeghi, M; Monteiro, O; Filippakopoulos, P; Picaud, S; Trzupek, JD; Gerstenberger, BS; Bountra, C; Willmann, D; Wells, C; Philpott, M; Rogers, C; Biggin, PC; Brennan, PE; Bunnage, ME; Schüle, R; Günther, T; Knapp, S; Knapp, S; Müller, S; 1:e1500723-Science Advances10.1126/sciadv.150072313.11.2015
The promise and peril of chemical probes (vol 11, pg 536, 2015)Arrowsmith, CH; Audia, JE; Austin, C; Baell, J; Bennett, J; Blagg, J; Bountra, C; Brennan, PE; Brown, PJ; Bunnage, ME; Buser-Doepner, C; Campbell, RM; Carter, AJ; Cohen, P; Copeland, RA; Cravatt, B; Dahlin, JL; Dhanak, D; Edwards, AM; Frederiksen, M; Frye, SV; Gray, N; Grimshaw, CE; Hepworth, D; Howe, T; Huber, KVM; Jin, J; Knapp, S; Kotz, JD; Kruger, RG; Lowe, D; Mader, MM; Marsden, B; Mueller-Fahrnow, A; Mueller, S; O'Hagan, RC; Overington, JP; Owen, DR; Rosenberg, SH; Ross, R; Roth, B; Schapira, M; Schreiber, SL; Shoichet, B; Sundstroem, M; Superti-Furga, G; Taunton, J; Toledo-Sherman, L; Walpole, C; Walters, MA; Willson, TM; Workman, P; Young, RN; Zuercher, WJ; 11:887-887Nature Chemical Biology10.1038/nchembio.193101.11.2015
26485069The ins and outs of selective kinase inhibitor development.Müller, S; Chaikuad, A; Gray, NS; Knapp, S; 11:818-821Nature Chemical Biology10.1038/nchembio.193801.11.2015
Inflammation activation and resolution in human tendon disease.Dakin, SG; Martinez, FO; Yapp, C; Wells, G; Oppermann, U; Dean, BJ; Smith, RDJ; Wheway, K; Watkins, B; Roche, L; Carr, AJ; 7:-Science Translational Medicine10.1126/scitranslmed.aac4269.28.10.2015
26489670New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.Zhang Q, Fan L, Hou F, Dong A, Wang YX, Tong Y5:15660Sci Rep10.1038/srep1566023.10.2015
26351135Overcoming ABCG2-mediated drug resistance with imidazo-[1,2-b]-pyridazine-based Pim1 kinase inhibitors.Darby, RAJ; Unsworth, A; Knapp, S; Kerr, ID; Callaghan, R; 76:853-864Cancer Chemotherapy and Pharmacology10.1007/s00280-015-2858-901.10.2015
26485080Corrigendum: The promise and peril of chemical probes.Arrowsmith, CH; Audia, JE; Austin, C; Baell, J; Bennett, J; Blagg, J; Bountra, C; Brennan, PE; Brown, PJ; Bunnage, ME; Buser-Doepner, C; Campbell, RM; Carter, AJ; Cohen, P; Copeland, RA; Cravatt, B; Dahlin, JL; Dhanak, D; Edwards, AM; Frederiksen, M; Frye, SV; Gray, N; Grimshaw, CE; Hepworth, D; Howe, T; Huber, KVM; Jin, J; Knapp, S; Kotz, JD; Kruger, RG; Lowe, D; Mader, MM; Marsden, B; Mueller-Fahrnow, A; Müller, S; O'Hagan, RC; Overington, JP; Owen, DR; Rosenberg, SH; Ross, R; Roth, B; Schapira, M; Schreiber, SL; Shoichet, B; Sundström, M; Superti-Furga, G; Taunton, J; Toledo-Sherman, L; Walpole, C; Walters, MA; Willson, TM; Workman, P; Young, RN; Zuercher, WJ; 11:887-Nature Chemical Biology10.1038/nchembio1115-887c01.11.2015
26472895STRUCTURAL BIOLOGY. Chromatin complex, crystal clear.Schapira M350(6258):278-9Science10.1126/science.aad520316.10.2015
26471359WDR5 supports an N-Myc transcriptional complex that drives a pro-tumorigenic gene expression signature in neuroblastoma.Sun Y, Bell JL, Carter DR, Gherardi S, Poulos RC, Milazzo G, Wong JW, Al-Awar R, Tee AE, Liu PY, Liu B, Atmadibrata B, Wong M, Trahair T, Zhao Q, Shohet JM, Haupt Y, Schulte JH, Brown PJ, Arrowsmith CH, Vedadi M, MacKenzie KL, Huttelmaier S, Perini G, Marshall GM, Braithwaite A, Liu TCancer Res.10.1158/0008-5472.CAN-15-042315.10.2015
26472031Targeting RIPK1,2,3 to combat inflammation.Bullock, AN; Degterev, A; 6:34057-34058Oncotarget10.18632/oncotarget.610601.10.2015
26421710High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant.Farnie, G; Sotgia, F; Lisanti, MP; 6:30472-30486Oncotarget10.18632/oncotarget.540101.10.2015
26437402Streamlining the Pipeline for Generation of Recombinant Affinity Reagents by Integrating the Affinity Maturation Step.Huang R, Gorman KT, Vinci CR, Dobrovetsky E, Gräslund S, Kay BK16(10):23587-603Int J Mol Sci10.3390/ijms16102358706.10.2015
26437229Optimizing Production of Antigens and Fabs in the Context of Generating Recombinant Antibodies to Human Proteins.Zhong N, Loppnau P, Seitova A, Ravichandran M, Fenner M, Jain H, Bhattacharya A, Hutchinson A, Paduch M, Lu V, Olszewski M, Kossiakoff AA, Dowdell E, Koide A, Koide S, Huang H, Nadeem V, Sidhu SS, Greenblatt JF, Marcon E, Arrowsmith CH, Edwards AM, Gräslund S10(10):e0139695PLoS ONE10.1371/journal.pone.013969505.10.2015
26425149Towards an understanding of the role of DNA methylation in rheumatoid arthritis: therapeutic and diagnostic implications.Cribbs A,Feldmann M,Oppermann U. Therapeutic advances in musculoskeletal diseasehttp://dx.doi.org/10.1177/1759720X15598307 01/10/2015
26431026TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export.Stadel D, Millarte V, Tillmann KD, Huber J, Tamin-Yecheskel BC, Akutsu M, Demishtein A, Ben-Zeev B, Anikster Y, Perez F, Dötsch V, Elazar Z, Rogov V, Farhan H, Behrends C.60(1):89-104Mol Cell10.1016/j.molcel.2015.09.01001.10.2015
26425149Towards an understanding of the role of DNA methylation in rheumatoid arthritis: therapeutic and diagnostic implications.Cribbs, A; Feldmann, M; Oppermann, U; 7:206-219Therapeutic Advances in Musculoskeletal Disease10.1177/1759720X1559830701.10.2015
26345662Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases.Thinnes, CC; Tumber, A; Yapp, C; Scozzafava, G; Yeh, T; Chan, MC; Tran, TA; Hsu, K; Tarhonskaya, H; Walport, LJ; Wilkins, SE; Martinez, ED; Müller, S; Pugh, CW; Ratcliffe, PJ; Brennan, PE; Kawamura, A; Schofield, CJ; 51:15458-15461Chemical Communications10.1039/c5cc06095h01.10.2015
26517908Structures and functions of mitochondrial ABC transporters.Schaedler, TA; Faust, B; Shintre, CA; Carpenter, EP; Srinivasan, V; van Veen, HW; Balk, J; 43:943-951Biochemical Society Transactions10.1042/bst2015011801.10.2015
26511510Inflammation activation and resolution in human tendon disease.Dakin, SG; Martinez, FO; Yapp, C; Wells, G; Oppermann, U; Dean, BJF; Smith, RDJ; Wheway, K; Watkins, B; Roche, L; Carr, AJ; 7:311ra173-Science Translational Medicine10.1126/scitranslmed.aac426901.10.2015
26397018Open access chemical probes for epigenetic targets.Brown PJ, Müller SFuture Med Chem10.4155/fmc.15.12723.09.2015
26389571Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling.Huber, KVM; Olek, KM; Müller, AC; Tan, CSH; Bennett, KL; Colinge, J; Superti-Furga, G; 12:1055-1057Nature Methods10.1038/nmeth.359001.11.2015
26391640Crystal structure of human nuclear pore complex component NUP43.Xu C, Li Z, He H, Wernimont A, Li Y, Loppnau P, Min JFEBS Lett.10.1016/j.febslet.2015.09.00819.09.2015
26387008WONKA: objective novel complex analysis for ensembles of protein-ligand structures.Bradley, AR; Wall, ID; von Delft, F; Green, DVS; Deane, CM; Marsden, BD; 29:963-973Journal of Computer-Aided Molecular Design10.1007/s10822-015-9866-z01.10.2015
26379026Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.Grebien, F; Vedadi, M; Getlik, M; Giambruno, R; Grover, A; Avellino, R; Skucha, A; Vittori, S; Kuznetsova, E; Smil, D; Barsyte-Lovejoy, D; Li, F; Poda, G; Schapira, M; Wu, H; Dong, A; Senisterra, G; Stukalov, A; Huber, KVM; Schönegger, A; Marcellus, R; Bilban, M; Bock, C; Brown, PJ; Zuber, J; Bennett, KL; Al-Awar, R; Delwel, R; Nerlov, C; Arrowsmith, CH; Superti-Furga, G; 11:815-Nature Chemical Biology10.1038/nchembio1015-815b01.10.2015
26331536Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth.Zhu J, Sammons MA, Donahue G, Dou Z, Vedadi M, Getlik M, Barsyte-Lovejoy D, Al-awar R, Katona BW, Shilatifard A, Huang J, Hua X, Arrowsmith CH, Berger SL525(7568):206-11Nature10.1038/nature1525110.09.2015
CSB interacts with SNM1A and promotes DNA interstrand crosslink processingIyama, T; Lee, SY; Berquist, BR; Gileadi, O; Bohr, VA; Seidman, MM; McHugh, PJ; Wilson, DM; 43:247-258Nucleic Acids Research10.1093/nar/gku12791.9.2015
26397018Open access chemical probes for epigenetic targets.Brown, PJ; Müller, S; 7:1901-1917Future Medicinal Chemistry10.4155/fmc.15.12701.1.2015
26318451Structural basis for the discriminative recognition of N6-methyladenosine RNA by the human YT521-B homology domain family of proteins.Xu C, Liu K, Ahmed H, Loppnau P, Schapira M, Min JJ. Biol. Chem.10.1074/jbc.M115.68038928.08.2015
26318908The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.Tsoumpra, MK; Muniz, JR; Barnett, BL; Kwaasi, AA; Pilka, ES; Kavanagh, KL; Evdokimov, A; Walter, RL; Von Delft, F; Ebetino, FH; Oppermann, U; Russell, RGG; Dunford, JE; 81:478-486BONE10.1016/j.bone.2015.08.02001.12.2015
26320211Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation.Colak, G; Pougovkina, O; Dai, L; Tan, M; Te Brinke, H; Huang, H; Cheng, Z; Park, J; Wan, X; Liu, X; Yue, WW; Wanders, RJA; Locasale, JW; Lombard, DB; de Boer, VCJ; Zhao, Y; 14:3056-3071Molecular and Cellular Proteomics10.1074/mcp.M115.04885001.11.2015
26320862Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors.Canning, P; Ruan, Q; Schwerd, T; Hrdinka, M; Maki, JL; Saleh, D; Suebsuwong, C; Ray, S; Brennan, PE; Cuny, GD; Uhlig, HH; Gyrd-Hansen, M; Degterev, A; Bullock, AN; 22:1174-1184Cell Chemistry Biology10.1016/j.chembiol.2015.07.01701.9.2015
26300989Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells.Curry E, Green I, Chapman-Rothe N, Shamsaei E, Kandil S, Cherblanc FL, Payne L, Bell E, Ganesh T, Srimongkolpithak N, Caron J, Li F, Uren AG, Snyder JP, Vedadi M, Fuchter MJ, Brown R7(1):84Clin Epigenetics10.1186/s13148-015-0118-921.08.2015
26056718Rational Polypharmacology: Systematically Identifying and Engaging Multiple Drug Targets To Promote 10(8):1939-51ACS Chem Biol.10.1021/acschembio.5b0028908.21.2015
26296892Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).Rouka, E; Simister, PC; Janning, M; Kumbrink, J; Konstantinou, T; Muniz, JRC; Joshi, D; O'Reilly, N; Volkmer, R; Ritter, B; Knapp, S; von Delft, F; Kirsch, KH; Feller, SM; 290:25275-25292Journal of Biological Chemistry10.1074/jbc.M115.63720701.10.2015
26290498A High Through-put Platform for Recombinant Antibodies to Folded Proteins.Hornsby M, Paduch M, Miersch S, Sääf A, Matsuguchi T, Lee B, Wypisniak K, Doak A, King D, Usatyuk S, Perry K, Lu V, Thomas W, Luke J, Goodman J, Hoey RJ, Lai D, Griffin C, Li Z, Vizeacoumar FJ, Dong D, Campbell E, Anderson S, Zhong N, Gräslund S, Koide S, Moffat J, Sidhu S, Kossiakoff A, Wells JMol. Cell Proteomics10.1074/mcp.O115.05220919.08.2015
27600229SPOTing Acetyl-Lysine Dependent Interactions.Picaud, S; Filippakopoulos, P; 4:370-388Microarrays10.3390/microarrays403037001.1.2015
26261308CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.Hammitzsch, A; Tallant, C; Fedorov, O; O'Mahony, A; Brennan, PE; Hay, DA; Martinez, FO; Al-Mossawi, MH; de Wit, J; Vecellio, M; Wells, C; Wordsworth, P; Müller, S; Knapp, S; Bowness, P; 112:10768-10773Proceedings of the National Academy of Sciences10.1073/pnas.150195611210.8.2015
26249686Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome.Wu H, Zeng H, Lam R, Tempel W, Kerr ID, Min J71(Pt 8):981-5Acta Crystallogr F Struct Biol Commun10.1107/S2053230X1501018301.08.2015
The salt inducible kinase 2 (SIK2) links lipid metabolism to survival of ovarian cancer metastasisMiranda, F; Liu, S; Herrero-Gonzalez, S; Mannion, D; Knapp, S; Ahmed, AA; 75:-Cancer Research10.1158/1538-7445.AM2015-41111.8.2015
2629124121(st) Century Cures Act: An Act of Cure or Diagnosis?Brindley, DA; Arshad, Z; Luo, D; Dopson, S; Hollander, G; Frost, S; Bountra, C; Smith, JA; 18:295-298Rejuvenation Research10.1089/rej.2015.175701.8.2015
26249344Defined PEG smears as an alternative approach to enhance the search for crystallization conditions and crystal-quality improvement in reduced screens.Chaikuad, A; Knapp, S; von Delft, F; 71:1627-1639Acta Crystallographica Section D: Biological Crystallography10.1107/S139900471500796801.8.2015
26232220A Call for Systematic Research on Solute Carriers.César-Razquin A, Snijder B, Frappier-Brinton T, Isserlin R, Gyimesi G, Bai X, Reithmeier RA, Hepworth D, Hediger MA, Edwards AM, Superti-Furga G162(3):478-87Cell10.1016/j.cell.2015.07.02230.07.2015
26212199BET Inhibition Upregulates SIRT1 and Alleviates Inflammatory Responses.Kokkola, T; Suuronen, T; Pesonen, M; Filippakopoulos, P; Salminen, A; Jarho, EM; Lahtela-Kakkonen, M; 16:1997-2001ChemBioChem: a European journal of chemical biology10.1002/cbic.20150027201.9.2015
26207746Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1).Yang, S-M; Yasgar, A; Miller, B; Lal-Nag, M; Brimacombe, K; Hu, X; Sun, H; Wang, A; Xu, X; Nguyen, K; Oppermann, U; Ferrer, M; Vasiliou, V; Simeonov, A; Jadhav, A; Maloney, DJ; 58:5967-5978Journal of Medicinal Chemistry10.1021/acs.jmedchem.5b0057713.8.2015
26320174A core of kinase-regulated interactomes defines the neoplastic MDSC lineage.Gato-Cañas, M; Martinez de Morentin, X; Blanco-Luquin, I; Fernandez-Irigoyen, J; Zudaire, I; Liechtenstein, T; Arasanz, H; Lozano, T; Casares, N; Chaikuad, A; Knapp, S; Guerrero-Setas, D; Escors, D; Kochan, G; Santamaría, E; 6:27160-27175Oncotarget10.18632/oncotarget.474601.9.2015
26196765Probing the epigenome.Huston A, Arrowsmith CH, Knapp S, Schapira M11(8):542-5Nat. Chem. Biol.10.1038/nchembio.187121.07.2015
26196764The promise and peril of chemical probes.Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Roth B, Ross R, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ11(8):536-41Nat. Chem. Biol.10.1038/nchembio.186721.07.2015
26199317Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design.Froese, DS; Michaeli, A; McCorvie, TJ; Krojer, T; Sasi, M; Melaev, E; Goldblum, A; Zatsepin, M; Lossos, A; Álvarez, R; Escribá, PV; Minassian, BA; von Delft, F; Kakhlon, O; Yue, WW; 24:5667-5676Human Molecular Genetics10.1093/hmg/ddv28001.10.2015
26167872Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.Grebien F, Vedadi M, Getlik M, Giambruno R, Grover A, Avellino R, Skucha A, Vittori S, Kuznetsova E, Smil D, Barsyte-Lovejoy D, Li F, Poda G, Schapira M, Wu H, Dong A, Senisterra G, Stukalov A, Huber KV, Schönegger A, Marcellus R, Bilban M, Bock C, Brown PJ, Zuber J, Bennett KL, Al-Awar R, Delwel R, Nerlov C, Arrowsmith CH, Superti-Furga GNat. Chem. Biol.10.1038/nchembio.185913.07.2015
26028650Transactivation Function-2 of Estrogen Receptor α Contains Transactivation Function-1 Regulating ElementArao, Y.; Coons L.A.; Zuercher W.J.; Korach K.S.290(28):17611-27J. Biol. Chem.10.1074/jbc.M115.63865007.10.2015
26158339Type II Inhibitors Targeting CDK2.Alexander, LT; Möbitz, H; Drueckes, P; Savitsky, P; Fedorov, O; Elkins, JM; Deane, CM; Cowan-Jacob, SW; Knapp, S; 10:2116-2125ACS Chemical Biology10.1021/acschembio.5b0039801.9.2015
26002073Designing selective inhibitors for calcium-dependent protein kinases in apicomplexans.Hui R, El Bakkouri M, Sibley LDTrends Pharmacol. Sci.10.1016/j.tips.2015.04.01105.07.2015
26145250Beating the odds: BETs in disease.Wang, C-Y; Filippakopoulos, P; 40:468-479Trends in Biochemical Sciences10.1016/j.tibs.2015.06.00201.8.2015
Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomainsHay, DA; Rogers, CM; Fedorov, O; Tallant, C; Martin, S; Monteiro, OP; Mueller, S; Knapp, S; Schofield, CJ; Brennan, PE; 6:1381-1386MedChemComm10.1039/c5md00152h01.01.2015
26687144Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation.Riemersma, M; Froese, DS; van Tol, W; Engelke, UF; Kopec, J; van Scherpenzeel, M; Ashikov, A; Krojer, T; von Delft, F; Tessari, M; Buczkowska, A; Swiezewska, E; Jae, LT; Brummelkamp, TR; Manya, H; Endo, T; van Bokhoven, H; Yue, WW; Lefeber, DJ; 22:1643-1652Cell Chemistry Biology10.1016/j.chembiol.2015.10.01410.12.2015
26133662Mutations in GMPPB cause congenital myasthenic syndrome and bridge myasthenic disorders with dystroglycanopathies.Belaya, K; Rodríguez Cruz, PM; Liu, WW; Maxwell, S; McGowan, S; Farrugia, ME; Petty, R; Walls, TJ; Sedghi, M; Basiri, K; Yue, WW; Sarkozy, A; Bertoli, M; Pitt, M; Kennett, R; Schaefer, A; Bushby, K; Parton, M; Lochmüller, H; Palace, J; Muntoni, F; Beeson, D; 138:2493-2504Brain10.1093/brain/awv18501.9.2015
26121405Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation.Marcon E, Jain H, Bhattacharya A, Guo H, Phanse S, Pu S, Byram G, Collins BC, Dowdell E, Fenner M, Guo X, Hutchinson A, Kennedy JJ, Krastins B, Larsen B, Lin ZY, Lopez MF, Loppnau P, Miersch S, Nguyen T, Olsen JB, Paduch M, Ravichandran M, Seitova A, Vadali G, Vogelsang MS, Whiteaker JR, Zhong G, Zhong N, Zhao L, Aebersold R, Arrowsmith CH, Emili A, Frappier L, Gingras AC, Gstaiger M, Paulovich AG, Koide S, Kossiakoff AA, Sidhu SS, Wodak SJ, Gräslund S, Greenblatt JF, Edwards AMNat. Methods10.1038/nmeth.347229.06.2015
26121039Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate.Trésaugues L, Lundbäck T, Welin M, Flodin S, Nyman T, Silvander C, Gräslund S, Nordlund P10(6):e0131507PLoS ONE10.1371/journal.pone.013150729.06.2015
26111701Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies.Anand, U; Yiangou, Y; Sinisi, M; Fox, M; MacQuillan, A; Quick, T; Korchev, YE; Bountra, C; McCarthy, T; Anand, P; 11:38-Molecular Pain10.1186/s12990-015-0038-x26.6.2015
25517376Food for thought.11:1-Nature Chemical Biology10.1038/nchembio.173001.1.2015
26112892Biochemical characterization of FIKK8-a unique protein kinase from the malaria parasite Plasmodium falciparum and other apicomplexans.Osman K, Lou HJ, Qiu W, Brand V, Edwards AM, Turk BE, Hui RMol. Biochem. Parasitol.10.1016/j.molbiopara.2015.06.00222.06.2015
26040720Regulation of endoplasmic reticulum turnover by selective autophagy.Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, Mauthe M, Katona I, Qualmann B, Weis J, Reggiori F, Kurth I, Hübner CA, Dikic I.522(7556):354-8Nature10.1038/nature1449818.06.2015
26040720Regulation of endoplasmic reticulum turnover by selective autophagy.Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A1, Nietzsche S, Koch N, Mauthe M3, Katona I, Qualmann B, Weis J, Reggiori F, Kurth I, Hübner CA, Dikic I.522(7556):354-8.Nature10.1038/nature1449818.06.2015
26081982Carnosine metabolism in diabetes is altered by reactive metabolites.Peters, V; Lanthaler, B; Amberger, A; Fleming, T; Forsberg, E; Hecker, M; Wagner, AH; Yue, WW; Hoffmann, GF; Nawroth, P; Zschocke, J; Schmitt, CP; 47:2367-2376Amino Acids10.1007/s00726-015-2024-z01.11.2015
26101576Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2.Sweis RF, Wang Z, Algire M, Arrowsmith CH, Brown PJ, Chiang GG, Guo J, Jakob CG, Kennedy S, Li F, Maag D, Shaw B, Soni NB, Vedadi M, Pappano WN6(6):695-700ACS Med Chem Lett10.1021/acsmedchemlett.5b0012411.06.2015
26061013Tankyrase 1 Inhibitors with Drug-like Properties Identified by Screening a DNA-Encoded Chemical Library.Samain F, Ekblad T, Mikutis G, Zhong N, Zimmermann M, Nauer A, Bajic D, Decurtins W, Scheuermann J, Brown PJ, Hall J, Gräslund S, Schüler H, Neri D, Franzini RMJ. Med. Chem.10.1021/acs.jmedchem.5b0043210.06.2015
26058458Pim Kinase Inhibitors Evaluated with a Single-Molecule Engineered Nanopore Sensor.Harrington, L; Alexander, LT; Knapp, S; Bayley, H; 54:8154-8159Angewandte Chemie International Edition10.1002/anie.20150314101.7.2015
26053025ATP Binding and Hydrolysis Properties of ABCB10 and Their Regulation by Glutathione.Qiu, W; Liesa, M; Carpenter, EP; Shirihai, OS; 10:e0129772-PLoS ONE10.1371/journal.pone.012977201.1.2015
26057936Structural basis of Keap1 interactions with Nrf2.Canning, P; Sorrell, FJ; Bullock, AN; 88:101-107Free Radical Biology and Medicine10.1016/j.freeradbiomed.2015.05.03401.11.2015
Development of SRPK1 inhibitors as novel anti-angiogenic therapeutics for exudative age-related macular degeneration (AMD)Batson, J; Troop, H; Rowlinson, J; Allen, C; Babaei-Jadidi, R; Zhang, J; Wearmouth, S; Knapp, S; Morris, J; Bates, D; 56:-Investigative Ophthalmology & Visual Science01.6.2015
26002201Kinetic characterization of human histone H3 lysine 36 methyltransferases, ASH1L and SETD2.Eram MS, Kuznetsova E, Li F, Lima-Fernandes E, Kennedy S, Chau I, Arrowsmith CH, Schapira M, Vedadi MBiochim. Biophys. Acta10.1016/j.bbagen.2015.05.01319.05.2015
27346896LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor.Clark, PGK; Vieira, LCC; Tallant, C; Fedorov, O; Singleton, DC; Rogers, CM; Monteiro, OP; Bennett, JM; Baronio, R; Müller, S; Daniels, DL; Méndez, J; Knapp, S; Brennan, PE; Dixon, DJ; 127:6315-6319Angewandte Chemie International Edition10.1002/ange.20150139401.5.2015
25974248Structural diversity of the epigenetics pocketome.Cabaye A, Nguyen KT, Liu L, Pande V, Schapira MProteins10.1002/prot.2483013.05.2015
25772490Identification of Covalent Bromodomain Binders through DNA Display of Small Molecules.Daguer, J-P; Zambaldo, C; Abegg, D; Barluenga, S; Tallant, C; Müller, S; Adibekian, A; Winssinger, N; 54:6057-6061Angewandte Chemie International Edition10.1002/anie.20141227601.5.2015
25941255IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production.Blazek, K; Eames, HL; Weiss, M; Byrne, AJ; Perocheau, D; Pease, JE; Doyle, S; McCann, F; Williams, RO; Udalova, IA; 212:845-853Journal of Experimental Medicine10.1084/jem.2014099501.6.2015
25996294A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis.Fauster, A; Rebsamen, M; Huber, KVM; Bigenzahn, JW; Stukalov, A; Lardeau, C-H; Scorzoni, S; Bruckner, M; Gridling, M; Parapatics, K; Colinge, J; Bennett, KL; Kubicek, S; Krautwald, S; Linkermann, A; Superti-Furga, G; 6:e1767-Cell Death and Disease10.1038/cddis.2015.13021.5.2015
25856009Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromdomain Containing Protein 9 InhibitionTheodoulou, N.H.; Bamborough, P.; Bannister, A.J.; Becher, I.; Bit, R.A.; Che, K.H.; Chung, C-W.; Dittmann, A.; Drewes, G.; Drewry, D.H.; Gordon, L.; Grandi, P.; Leveridge, M.; Lindon, M.; Michon, A-M.; Molnar, J.; Robson, S.C.; Tomkinson, N.C.O.; Kouzarides, T.; Prinjha, R.K.; Humphreys, P.G. J. Med. Chem.10.1021/acs.jmedchem.5b0025604.30.2015
25901030Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.Newman, JA; Savitsky, P; Allerston, CK; Bizard, AH; Özer, Ö; Sarlós, K; Liu, Y; Pardon, E; Steyaert, J; Hickson, ID; Gileadi, O; 43:5221-5235Nucleic Acids Research10.1093/nar/gkv37301.5.2015
25945703Solution-state NMR structure of the putative morphogene protein BolA (PFE0790c) from Plasmodium falciparum.Buchko GW, Yee A, Semesi A, Myler PJ, Arrowsmith CH, Hui R71(Pt 5):514-21Acta Crystallogr F Struct Biol Commun10.1107/S2053230X1402799X18.04.2015
25864491LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor.Clark, PG; Vieira, LC; Tallant, C; Fedorov, O; Singleton, DC; Rogers, CM; Monteiro, OP; Bennett, JM; Baronio, R; Müller, S; Daniels, DL; Méndez, J; Knapp, S; Brennan, PE; Dixon, DJ; 54:6217-6221Angewandte Chemie International Edition01.5.2015
25866208Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: DETERMINANTS OF DNA BINDING AND REDOX REGULATION BY DISULFIDE BOND FORMATION.Cooper, CDO; Newman, JA; Aitkenhead, H; Allerston, CK; Gileadi, O; 290:13692-13709Journal of Biological Chemistry10.1074/jbc.M115.64673701.5.2015
25893041Discovery of a Dual PRMT5-PRMT7 Inhibitor.Smil D, Eram MS, Li F, Kennedy S, Szewczyk MM, Brown PJ, Barsyte-Lovejoy D, Arrowsmith CH, Vedadi M, Schapira M6(4):408-12ACS Med Chem Lett10.1021/ml500467h09.04.2015
25861861Perspective on computational and structural aspects of kinase discovery from IPK2014.Martin, E; Knapp, S; Engh, RA; Moebitz, H; Varin, T; Roux, B; Meiler, J; Berdini, V; Baumann, A; Vieth, M; 1854:1595-1604BBA - Biochimica et Biophysica Acta10.1016/j.bbapap.2015.03.01401.10.2015
25857453Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation.Liu K, Liu Y, Lau JL, Min JPharmacol. Ther.10.1016/j.pharmthera.2015.04.00106.04.2015
25847873Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design.Mohanty S, Kennedy EJ, Herberg FW, Hui R, Taylor SS, Langsley G, Kannan NBiochim. Biophys. Acta10.1016/j.bbapap.2015.03.01203.04.2015
25393219Nanog requires BRD4 to maintain murine embryonic stem cell pluripotency and is suppressed by bromodomain inhibitor JQ1 together with Lefty1.Horne, GA; Stewart, HJS; Dickson, J; Knapp, S; Ramsahoye, B; Chevassut, T; 24:879-891Stem Cells and Development10.1089/scd.2014.030201.4.2015
29308157Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action.Babak, MV; Meier, SM; Huber, KVM; Reynisson, J; Legin, AA; Jakupec, MA; Roller, A; Stukalov, A; Gridling, M; Bennett, KL; Colinge, J; Berger, W; Dyson, PJ; Superti-Furga, G; Keppler, BK; Hartinger, CG; 6:2449-2456Chemical Science10.1039/c4sc03905j01.4.2015
25825497LLY-507, a Cell-Active, Potent and Selective Inhibitor of Protein Lysine Methyltransferase SMYD2.Nguyen H, Allali-Hassani A, Antonysamy S, Chang S, Chen LH, Curtis C, Emtage S, Fan L, Gheyi T, Li F, Liu S, Martin JR, Mendel D, Olsen JB, Pelletier L, Shatseva T, Wu S, Zhang FF, Arrowsmith CH, Brown PJ, Campbell RM, Garcia BA, Barsyte-Lovejoy D, Mader M, Vedadi MJ. Biol. Chem.10.1074/jbc.M114.62686130.03.2015
25822739Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents.Kovackova, S; Chang, L; Bekerman, E; Neveu, G; Barouch-Bentov, R; Chaikuad, A; Heroven, C; Šála, M; De Jonghe, S; Knapp, S; Einav, S; Herdewijn, P; 58:3393-3410Journal of Medicinal Chemistry10.1021/jm501759m9.4.2015
25561175SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.Rebsamen, M; Pochini, L; Stasyk, T; de Araújo, MEG; Galluccio, M; Kandasamy, RK; Snijder, B; Fauster, A; Rudashevskaya, EL; Bruckner, M; Scorzoni, S; Filipek, PA; Huber, KVM; Bigenzahn, JW; Heinz, LX; Kraft, C; Bennett, KL; Indiveri, C; Huber, LA; Superti-Furga, G; 519:477-481Nature10.1038/nature1410701.3.2015
25831490Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structures.Pike, ACW; Gomathinayagam, S; Swuec, P; Berti, M; Zhang, Y; Schnecke, C; Marino, F; von Delft, F; Renault, L; Costa, A; Gileadi, O; Vindigni, A; 112:4286-4291Proceedings of the National Academy of Sciences10.1073/pnas.141759411201.4.2015
25684205CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.Genau HM, Huber J, Baschieri F, Akutsu M, Dötsch V, Farhan H, Rogov V, Behrends C.57(6):995-1010Mol Cell10.1016/j.molcel.2014.12.04019.03.2015
26387946Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.Simões, BM; O'Brien, CS; Eyre, R; Silva, A; Yu, L; Sarmiento-Castro, A; Alférez, DG; Spence, K; Santiago-Gómez, A; Chemi, F; Acar, A; Gandhi, A; Howell, A; Brennan, K; Rydén, L; Catalano, S; Andó, S; Gee, J; Ucar, A; Sims, AH; Marangoni, E; Farnie, G; Landberg, G; Howell, SJ; Clarke, RB; 12:1968-1977Cell Reports10.1016/j.celrep.2015.08.05017.9.2015
25766236K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.Dong, YY; Pike, ACW; Mackenzie, A; McClenaghan, C; Aryal, P; Dong, L; Quigley, A; Grieben, M; Goubin, S; Mukhopadhyay, S; Ruda, GF; Clausen, MV; Cao, L; Brennan, PE; Burgess-Brown, NA; Sansom, MSP; Tucker, SJ; Carpenter, EP; 347:1256-1259Science10.1126/science.126151201.3.2015
25740547New compound sets identified from high throughput screening against three kinetoplastid parasites: an open resourceena, I.; Pilar Manzano, M.; Cantizani, J.; Kessler, A.; Alonso-Padilla, J.; Bardera, A.I.; Alvarez, E.; Colmenarejo, G.; Cotillo, I.; Roquero, I.; de Dios-Anton, F.; Barroso, V.; Rodriquez, A.; Gray, D.W.; Navarro, M.; Kumar, V.; Sherstnev, A.; Drewry, D.H.; Brown, J.R.; Fiandor, J.M.; Martin, Julio J. 5:8771Sci. Rep.10.1038/srep0877103.05.2015
2573026210-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A.Falke, H; Chaikuad, A; Becker, A; Loaëc, N; Lozach, O; Abu Jhaisha, S; Becker, W; Jones, PG; Preu, L; Baumann, K; Knapp, S; Meijer, L; Kunick, C; 58:3131-3143Journal of Medicinal Chemistry10.1021/jm501994d01.4.2015
25708309Building a roadmap for developing combination therapies for Alzheimer's disease.Perry, D; Sperling, R; Katz, R; Berry, D; Dilts, D; Hanna, D; Salloway, S; Trojanowski, JQ; Bountra, C; Krams, M; Luthman, J; Potkin, S; Gribkoff, V; Temple, R; Wang, Y; Carrillo, MC; Stephenson, D; Snyder, H; Liu, E; Ware, T; McKew, J; Fields, FO; Bain, LJ; Bens, C; 15:327-333Expert Review of Neurotherapeutics10.1586/14737175.2015.99655101.3.2015
Status of the crystallography beamlines at Diamond Light SourceAllan, DR; Collins, SP; Evans, G; Hall, D; McAuley, K; Owen, RL; Sorensen, T; Tang, CC; von Delft, F; Wagner, A; Wilhelm, H; 130:-European Physical Journal Plus10.1140/epjp/i2015-15056-x31.3.2015
25728001A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3).Kaniskan HÜ, Szewczyk MM, Yu Z, Eram MS, Yang X, Schmidt K, Luo X, Dai M, He F, Zang I, Lin Y, Kennedy S, Li F, Dobrovetsky E, Dong A, Smil D, Min SJ, Landon M, Lin-Jones J, Huang XP, Roth BL, Schapira M, Atadja P, Barsyte-Lovejoy D, Arrowsmith CH, Brown PJ, Zhao K, Jin J, Vedadi MAngew. Chem. Int. Ed. Engl.10.1002/anie.20141215427.02.2015
25719566Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B.Drouin, L; McGrath, S; Vidler, LR; Chaikuad, A; Monteiro, O; Tallant, C; Philpott, M; Rogers, C; Fedorov, O; Liu, M; Akhtar, W; Hayes, A; Raynaud, F; Müller, S; Knapp, S; Hoelder, S; 58:2553-2559Journal of Medicinal Chemistry10.1021/jm501963e01.3.2015
25752541Ankyrin Repeats of ANKRA2 Recognize a PxLPxL Motif on the 3M Syndrome Protein CCDC8.Nie J, Xu C, Jin J, Aka JA, Tempel W, Nguyen V, You L, Weist R, Min J, Pawson T, Yang XJStructure10.1016/j.str.2015.02.00126.02.2015
257035239H-purine scaffold reveals induced-fit pocket plasticity of the BRD9 bromodomain.Picaud, S; Strocchia, M; Terracciano, S; Lauro, G; Mendez, J; Daniels, DL; Riccio, R; Bifulco, G; Bruno, I; Filippakopoulos, P; 58:2718-2736Journal of Medicinal Chemistry10.1021/jm501893k5.3.2015
25722227Preclinical target validation using patient-derived cells.Edwards AM, Arrowsmith CH, Bountra C, Bunnage ME, Feldmann M, Knight JC, Patel DD, Prinos P, Taylor MD, Sundström M, Barker P, Barsyte D, Bengtson MH, Bell C, Bowness P, Boycott KM, Buser-Doepner C, Carpenter CL, Carr AJ, Clark K, Das AM, Dhanak D, Dirks P, Ellis J, Fantin VR, Flores C, Fon EA, Frail DE, Gileadi O, O'Hagan RC, Howe T, Isaac JT, Jabado N, Jakobsson PJ, Klareskog L, Knapp S, Lee WH, Lima-Fernandes E, Lundberg IE, Marshall J, Massirer KB, MacKenzie AE, Maruyama T, Mueller-Fahrnow A, Muthuswamy S, Nanchahal J, O'Brien C, Oppermann U, Ostermann N, Petrecca K, Pollock BG, Poupon V, Prinjha RK, Rosenberg SH, Rouleau G, Skingle M, Slutsky AS, Smith GA, Verhelle D, Widmer H, Young LT14(3):149-50Nat Rev Drug Discov10.1038/nrd456520.02.2015
26073602MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes.Stansfeld, PJ; Goose, JE; Caffrey, M; Carpenter, EP; Parker, JL; Newstead, S; Sansom, MS; 23:1350-1361Structure10.1016/j.str.2015.05.00601.7.2015
25670864Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2.Newman, JA; Cooper, CDO; Aitkenhead, H; Gileadi, O; 290:8539-8549Journal of Biological Chemistry10.1074/jbc.M114.61927001.3.2015
25650139Identification of Structure-Activity Relationships from Screening a Structurally Compact DNA-Encoded Chemical Library.Franzini RM, Ekblad T, Zhong N, Wichert M, Decurtins W, Nauer A, Zimmermann M, Samain F, Scheuermann J, Brown PJ, Hall J, Gräslund S, Schüler H, Neri DAngew. Chem. Int. Ed. Engl.10.1002/anie.20141073603.02.2015
25187396Focal adhesion kinase and Wnt signaling regulate human ductal carcinoma in situ stem cell activity and response to radiotherapy.Williams, KE; Bundred, NJ; Landberg, G; Clarke, RB; Farnie, G; 33:327-341STEM CELLS10.1002/stem.184301.2.2015
25630512Dentine matrix protein 1 (DMP-1) is a marker of bone formation and mineralisation in soft tissue tumours.Inagaki, Y; Kashima, TG; Hookway, ES; Tanaka, Y; Hassan, AB; Oppermann, U; Athanasou, NA; 466:445-452Virchows Archiv: an international journal of pathology10.1007/s00428-014-1706-301.4.2015
Absolute Binding Free Energy Calculations of Bromodomain InhibitorsAldeghi, M; Knapp, S; Heifetz, A; Barker, JJ; Bodkin, MJ; Law, RJ; Biggin, PC; 108:357A-357ABiophysical Journal10.1016/j.bpj.2014.11.195427.1.2015
25619643Human prostaglandin reductase 1 (PGR1): Substrate specificity, inhibitor analysis and site-directed mutagenesis.Mesa, J; Alsina, C; Oppermann, U; Parés, X; Farrés, J; Porté, S; 234:105-113Chemico-Biological Interactions10.1016/j.cbi.2015.01.0215.6.2015
25604857Clinical Utility Gene Card for: Fibrodysplasia ossificans progressiva.Bravenboer, N; Micha, D; Triffit, JT; Bullock, AN; Ravazollo, R; Bocciardi, R; di Rocco, M; Netelenbos, JC; Ten Dijke, P; Sánchez-Duffhues, G; Kaplan, FS; Shore, EM; Pignolo, RJ; Seemann, P; Ventura, F; Beaujat, G; Eekhoff, EMW; Pals, G; 23:-European Journal of Human Genetics10.1038/ejhg.2014.27401.10.2015
Perspective on computational and structural aspects of kinase discovery from IPK2014Martin, E; Knapp, S; Engh, RA; Moebitz, H; Varin, T; Roux, B; Meiler, J; Berdini, V; Baumann, A; Vieth, M; 1854:1595-1604BBA - Proteins and Proteomics10.1016/j.bbapap.2015.03.0141.10.2015
25595038Bisubstrate inhibitor approach for targeting mitotic kinase Haspin.Kestav, K; Lavogina, D; Raidaru, G; Chaikuad, A; Knapp, S; Uri, A; 26:225-234Bioconjugate Chemistry10.1021/bc500464r01.2.2015
25238254Identification and structure-function analysis of subfamily selective G protein-coupled receptor kinase inhibitors.Homan, KT; Larimore, KM; Elkins, JM; Szklarz, M; Knapp, S; Tesmer, JJG; 10:310-319ACS Chemical Biology10.1021/cb500632301.1.2015
25590533Identification of a Fragment-like Small Molecule Ligand for the Methyl-lysine Binding Protein, 53BP1.Perfetti MT, Baughman BM, Dickson BM, Mu Y, Cui G, Mader P, Dong A, Norris JL, Rothbart SB, Strahl BD, Brown PJ, Janzen WP, Arrowsmith CH, Mer G, McBride KM, James LI, Frye SVACS Chem. Biol.10.1021/cb500956g15.01.2015
25500191PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection.McEwan DG, Richter B, Claudi B, Wigge C, Wild P, Farhan H, McGourty K, Coxon FP, Franz-Wachtel M, Perdu B, Akutsu M, Habermann A, Kirchof A, Helfrich MH, Odgren PR, Van Hul W, Frangakis AS, Rajalingam K, Macek B, Holden DW, Bumann D, Dikic I.17(1):58-71Cell Host Microbe10.1016/j.chom.2014.11.01114.01.2015
25564516Lysine Demethylase KDM4A Associates with Translation Machinery and Regulates Protein Synthesis.Van Rechem C, Black JC, Boukhali M, Aryee MJ, Graslund S, Haas W, Benes CH, Whetstine JRCancer Discov10.1158/2159-8290.CD-14-132606.01.2015
25557927A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis.Kerr, G; Sheldon, H; Chaikuad, A; Alfano, I; von Delft, F; Bullock, AN; Harris, AL; 18:209-217Angiogenesis10.1007/s10456-014-9457-y01.4.2015
25554733Structure-activity relationship studies of SETD8 inhibitors.Ma A, Yu W, Xiong Y, Butler KV, Brown PJ, Jin J5(12):1892-1898Medchemcomm10.1039/C4MD00317A03.01.2015
25382253Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1.Wilbek, TS; Skovgaard, T; Sorrell, FJ; Knapp, S; Berthelsen, J; Strømgaard, K; 16:59-63ChemBioChem10.1002/cbic.20140251201.1.2015
Synthesis of Highly Water-Soluble Adamantyl Phosphoinositide DerivativesGregory, M; Yin, M-X; McConville, MJ; Williams, E; Bullock, AN; Conway, SJ; Burgess, AW; Catimel, B; Holmes, AB; 68:543-548Australian Journal of Chemistry10.1071/CH1454301.01.2015
25502203Application of in situ diffraction in high-throughput structure determination platforms.Aller, P; Sanchez-Weatherby, J; Foadi, J; Winter, G; Lobley, CMC; Axford, D; Ashton, AW; Bellini, D; Brandao-Neto, J; Culurgioni, S; Douangamath, A; Duman, R; Evans, G; Fisher, S; Flaig, R; Hall, DR; Lukacik, P; Mazzorana, M; McAuley, KE; Mykhaylyk, V; Owen, RL; Paterson, NG; Romano, P; Sandy, J; Sorensen, T; von Delft, F; Wagner, A; Warren, A; Williams, M; Stuart, DI; Walsh, MA; 1261:233-253Methods in Molecular Biology10.1007/978-1-4939-2230-7_1301.1.2015
Genome-wide profiling of molecular recognition of histone PTMsFilippakopoulos, P; Knapp, S; :173-18410.1007/978-3-319-18102-8_81.1.2015
The global cancer genomics consortium’s symposium: New era of molecular medicine and epigenetic cancer medicine - Cross section of genomics and epigeneticsToi, M; Pillai, MR; Gupta, S; Badwe, R; Carmo-Fonseca, M; Costa, L; Chow, LWC; Knapp, S; Kumar, R; 6:1-8Genes and Cancer1.1.2015
25533489Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC.Tallant, C; Valentini, E; Fedorov, O; Overvoorde, L; Ferguson, FM; Filippakopoulos, P; Svergun, DI; Knapp, S; Ciulli, A; 23:80-92Structure10.1016/j.str.2014.10.01701.1.2015
25526675Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships.Bhatia, C; Oerum, S; Bray, J; Kavanagh, KL; Shafqat, N; Yue, W; Oppermann, U; 234:114-125Chemico-Biological Interactions10.1016/j.cbi.2014.12.0135.6.2015
25505141CSB interacts with SNM1A and promotes DNA interstrand crosslink processing.Iyama, T; Lee, SY; Berquist, BR; Gileadi, O; Bohr, VA; Seidman, MM; McHugh, PJ; Wilson, DM; 43:247-258Nucleic Acids Research10.1093/nar/gku127901.1.2015
25433853The role of calcium and nicotinic acid adenine dinucleotide phosphate (NAADP) in human osteoclast formation and resorption.Cheng, X; Hookway, ES; Kashima, T; Oppermann, U; Galione, A; Athanasou, NA; 96:73-79Calcified Tissue International10.1007/s00223-014-9939-301.1.2015
25368322Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation.Horbelt, D; Boergermann, JH; Chaikuad, A; Alfano, I; Williams, E; Lukonin, I; Timmel, T; Bullock, AN; Knaus, P; 290:3390-3404Journal of Biological Chemistry10.1074/jbc.M114.60439701.2.2015
24939588Linking genotypes database with locus-specific database and genotype-phenotype correlation in phenylketonuria.Wettstein, S; Underhaug, J; Perez, B; Marsden, BD; Yue, WW; Martinez, A; Blau, N; 23:302-309European Journal of Human Genetics10.1038/ejhg.2014.11401.3.2015
24442880Leri's pleonosteosis, a congenital rheumatic disease, results from microduplication at 8q22.1 encompassing GDF6 and SDC2 and provides insight into systemic sclerosis pathogenesis.Banka, S; Cain, SA; Carim, S; Daly, SB; Urquhart, JE; Erdem, G; Harris, J; Bottomley, M; Donnai, D; Kerr, B; Kingston, H; Superti-Furga, A; Unger, S; Ennis, H; Worthington, J; Herrick, AL; Merry, CLR; Yue, WW; Kielty, CM; Newman, WG; 74:1249-1256Annals of the Rheumatic Diseases10.1136/annrheumdis-2013-20430901.6.2015
25632347Function through bio-inspired, synthesis-informed design: step-economical syntheses of designed kinase inhibitorsWender, P. A.; Axtman, A. D.; Golden, J. E.; Kee, J.-M.; Sirois, L. E.; Quiroz, R. V.; Stevens, M. C.1166-1171Chem. Front. 12.29.2014
25530082Recombinant renewable polyclonal antibodies.Ferrara F, D'Angelo S, Gaiotto T, Naranjo L, Tian H, Gräslund S, Dobrovetsky E, Hraber P, Lund-Johansen F, Saragozza S, Sblattero D, Kiss C, Bradbury ARMAbs10.4161/19420862.2015.98904720.12.2014
26693001Structural biology and chemistry of protein arginine methyltransferases.Schapira M, Ferreira de Freitas R5(12):1779-1788Medchemcomm10.1039/c4md00269e19.12.2014
25750706Identification of 2,4-diamino-6,7-dimethoxyquinoline derivatives as G9a inhibitors†Electronic supplementary information (ESI) available. See DOI: 10.1039/c4md00274a.Srimongkolpithak N, Sundriyal S, Li F, Vedadi M, Fuchter MJ5(12):1821-1828Medchemcomm10.1039/c4md00274a19.12.2014
25516793Crystal Structure of Sphingosine Kinase 1 with PF-543.Wang, J; Knapp, S; Pyne, NJ; Pyne, S; Elkins, JM; 5:1329-1333ACS Medicinal Chemistry Letters10.1021/ml500407401.12.2014
25485837BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence.Gu L, Frommel SC, Oakes CC, Simon R, Grupp K, Gerig CY, Bär D, Robinson MD, Baer C, Weiss M, Gu Z, Schapira M, Kuner R, Sültmann H, Provenzano M, Yaspo ML, Brors B, Korbel J, Schlomm T, Sauter G, Eils R, Plass C, Santoro RNat. Genet.10.1038/ng.316508.12.2014
Further Evaluation of Pro-Atherogenic and Anti-Angiogenic Effects of Nilotinib in Mice and in Patients with Ph-Chromosome plus CMLHadzijusufovic, E; Albrecht-Schgoer, K; Huber, K; Grebien, F; Eisenwort, G; Schgoer, W; Kaun, C; Herndlhofer, S; Theurl, M; Cerny-Reiterer, S; Hoermann, G; Sperr, WR; Rix, U; Sadovnik, I; Jilma, B; Schernthaner, GH; Wojta, J; Wolf, D; Superti-Furga, G; Kirchmair, R; Valent, P; 124:-Blood6.12.2014
Targeting Aberrant Self-Renewal of Leukemic Cells with a Novel CBP/p300 Bromodomain InhibitorThanasopoulou, A; Dumrese, K; Picaud, S; Fedorov, O; Knapp, S; Schwaller, J; 124:-Blood6.12.2014
25484917A global assessment of cancer genomic alterations in epigenetic mechanisms.Shah MA, Denton EL, Arrowsmith CH, Lupien M, Schapira M7(1):29Epigenetics Chromatin10.1186/1756-8935-7-2904.12.2014
Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomainChaikuad, A; Petros, AM; Fedorov, O; Xu, J; Knapp, S; 5:1843-1848MedChemComm10.1039/c4md00237g01.01.2014
Copper is required for oncogenic BRAF signaling and tumorigenesisBrady, D; Crowe, M; Turski, M; Hobbs, A; Yao, X; Chaikuad, A; Knapp, S; Xiao, K; Campbell, S; Thiele, D; Counter, C; 12:-Molecular Cancer Research10.1158/1557-3125.RASONC14-IA0901.12.2014
25186459The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex.Abdul Azeez, KR; Knapp, S; Fernandes, JMP; Klussmann, E; Elkins, JM; 464:231-239Biochemical Journal10.1042/BJ2014060601.12.2014
26682034Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.England, KS; Tumber, A; Krojer, T; Scozzafava, G; Ng, SS; Daniel, M; Szykowska, A; Che, K; von Delft, F; Burgess-Brown, NA; Kawamura, A; Schofield, CJ; Brennan, PE; 5:1879-1886MedChemComm10.1039/C4MD00291A01.12.2014
Natural killer (NK) cells and gamma delta T-cells differentially modulate Th17-driven disease in ankylosing spondylitisWythe, SE; Griseri, T; Demetriou, P; Freidin, A; Feldmann, M; McCann, FE; Horwood, N; 143:162-162Immunology01.12.2014
25395428Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia.Xu B, On DM, Ma A, Parton T, Konze KD, Pattenden SG, Allison DF, Cai L, Rockowitz S, Liu S, Liu Y, Li F, Vedadi M, Frye SV, Garcia BA, Zheng D, Jin J, Wang GGBlood10.1182/blood-2014-06-58108213.11.2014
25426115The Humoral Immune Response to HCV: Understanding is Key to Vaccine Development.Cashman, SB; Marsden, BD; Dustin, LB; 5:550-Frontiers in Immunology10.3389/fimmu.2014.0055001.1.2014
25514179PINK1-PARKIN interplay: down to ubiquitin phosphorylation.Stolz A, Dikic I.56(3):341-2Mol Cell10.1016/j.molcel.2014.10.02206.11.2014
25418155Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures.Chatterjee, S; Zagelbaum, J; Savitsky, P; Sturzenegger, A; Huttner, D; Janscak, P; Hickson, ID; Gileadi, O; Rothenberg, E; 5:5556-Nature Communications10.1038/ncomms655624.11.2014
25485134Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation.Dong C, Zhang H, Xu C, Arrowsmith CH, Min J1(Pt 6):540-549IUCrJ10.1107/S205225251402092201.11.2014
25535791Purification and interaction analyses of two human lysosomal vitamin B12 transporters: LMBD1 and ABCD4.Deme, JC; Hancock, MA; Xia, X; Shintre, CA; Plesa, M; Kim, JC; Carpenter, EP; Rosenblatt, DS; Coulton, JW; 31:250-261Molecular Membrane Biology10.3109/09687688.2014.99099801.11.2014
25343681X-ray Structure of a Hg2+ Complex of Mercuric Reductase (MerA) and QM/MM Study of Hg2+ Transfer between the C-terminal and Buried Catalytic Site Cysteine Pairs.Lian P, Guo HB, Riccardi D, Dong A, Parks JM, Xu Q, Pai EF, Miller SM, Wei DQ, Smith JC, Guo HBiochemistry10.1021/bi500608u24.10.2014
25336647Inter-domain communication of human cystathionine β-synthase: structural basis of S-adenosyl-L-methionine activation.McCorvie, TJ; Kopec, J; Hyung, S-J; Fitzpatrick, F; Feng, X; Termine, D; Strain-Damerell, C; Vollmar, M; Fleming, J; Janz, JM; Bulawa, C; Yue, WW; 289:36018-36030Journal of Biological Chemistry10.1074/jbc.M114.61078201.12.2014
Selective Targeting of Protein Interactions Mediated by BET BromodomainsMüller, S; Lingard, H; Knapp, S; 9783527336111:295-30810.1002/9783527687503.ch206.10.2014
Nilotinib exerts proatherogenic and growth-inhibitory effects on endothelial cells: a potential mechanism underlying drug-related vasculopathy in Ph plus CMLHadzijusufovic, E; Albrecht-Schgoer, K; Huber, K; Grebien, F; Eisenwort, G; Schgoer, W; Ghanim, V; Sadovnik, I; Kaun, C; Herndlhofer, S; Theurl, M; Cerny-Reiterer, S; Hoermann, G; Jilma, B; Sperr, WR; Rix, U; Wojta, J; Wolf, D; Superti-Furga, G; Kirchmair, R; Valent, P; 37:300-300Oncology Research and Treatment01.10.2014
Dual kinase/bromodomain inhibitors for rationally designed polypharmacologyQuinn, ER; Ciceri, P; Mueller-Knapp, S; O'Mahony, A; Fedorov, O; Filippakopoulos, P; Hunt, JP; Lasater, EA; Pallares, G; Picaud, S; Wells, C; Wodicka, LM; Shah, NP; Knapp, S; Treiber, DK; 74:-Cancer Research10.1158/1538-7445.AM2014-53871.10.2014
25195011A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics.Chaikuad, A; Tacconi, EMC; Zimmer, J; Liang, Y; Gray, NS; Tarsounas, M; Knapp, S; 10:853-860Nature Chemical Biology10.1038/nchembio.162901.10.2014
25286854Using textons to rank crystallization droplets by the likely presence of crystals.Ng, JT; Dekker, C; Kroemer, M; Osborne, M; von Delft, F; 70:2702-2718Acta Crystallographica Section D: Biological Crystallography10.1107/S139900471401758101.10.2014
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25277115Structure and function of the nucleosome-binding PWWP domain.Qin S, Min JTrends Biochem. Sci.10.1016/j.tibs.2014.09.00129.09.2014
25244105OOMMPPAA: a tool to aid directed synthesis by the combined analysis of activity and structural data.Bradley, AR; Wall, ID; Green, DVS; Deane, CM; Marsden, BD; 54:2636-2646Journal of Chemical Information and Modeling10.1021/ci500245d9.10.2014
25242552Structural basis for selective binding of m(6)A RNA by the YTHDC1 YTH domain.Xu C, Wang X, Liu K, Roundtree IA, Tempel W, Li Y, Lu Z, He C, Min JNat. Chem. Biol.10.1038/nchembio.165421.09.2014
25030770Comparison of the substrate selectivity and biochemical properties of human and bacterial gamma-butyrobetaine hydroxylase.Rydzik AM,Leung IK,Kochan GT,Loik ND,Henry L,McDonough MA,Claridge TD,Schofield CJ. 12(33):6354-6358Organic & biomolecular chemistryhttp://dx.doi.org/10.1039/c4ob01167h 07/09/2014
25188378Inhibition of the SR protein-phosphorylating CLK kinases of Plasmodium falciparum impairs blood stage replication and malaria transmission.Kern, S; Agarwal, S; Huber, K; Gehring, AP; Strödke, B; Wirth, CC; Brügl, T; Abodo, LO; Dandekar, T; Doerig, C; Fischer, R; Tobin, AB; Alam, MM; Bracher, F; Pradel, G; 9:e105732-PLoS ONE10.1371/journal.pone.010573201.1.2014
24614495Preliminary evidence that early reduction in p11 levels in natural killer cells and monocytes predicts the likelihood of antidepressant response to chronic citalopramSvenningsson P, Berg L, Matthews D, Ionescu DF, Richards EM, Niciu MJ, Malinger A, Toups M, Manji H, Trivedi MH, Zarate CA, Greengard P. 19(9):962-4Mol Psychiatry10.1038/mp.2014.13Sep 2014
25064833The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity.Winter, GE; Radic, B; Mayor-Ruiz, C; Blomen, VA; Trefzer, C; Kandasamy, RK; Huber, KVM; Gridling, M; Chen, D; Klampfl, T; Kralovics, R; Kubicek, S; Fernandez-Capetillo, O; Brummelkamp, TR; Superti-Furga, G; 10:768-773Nature Chemical Biology10.1038/nchembio.159001.9.2014
Reconfiguring drug discovery through innovative partnershipsGrundy, R; James, L; Bountra, C; Harrison, T; 15:70-74Ddw Drug Discovery World1.1.2014
X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanismChen, L; Durr, KL; Gouaux, E; 345:1021-1026Science10.1126/science.125840929.8.2014
25176127Sulfated glycosaminoglycans control the extracellular trafficking and the activity of the metalloprotease inhibitor TIMP-3.Troeberg, L; Lazenbatt, C; Anower-E-Khuda, MF; Freeman, C; Federov, O; Habuchi, H; Habuchi, O; Kimata, K; Nagase, H; 21:1300-1309Chemistry and Biology01.10.2014
25144743Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer.Birol, M; Enchev, RI; Padilla, A; Stengel, F; Aebersold, R; Betzi, S; Yang, Y; Hoh, F; Peter, M; Dumas, C; Echalier, A; 9:e105688-PLoS ONE10.1371/journal.pone.010568801.1.2014
25136132(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.Barsyte-Lovejoy D, Li F, Oudhoff MJ, Tatlock JH, Dong A, Zeng H, Wu H, Freeman SA, Schapira M, Senisterra GA, Kuznetsova E, Marcellus R, Allali-Hassani A, Kennedy S, Lambert JP, Couzens AL, Aman A, Gingras AC, Al-Awar R, Fish PV, Gerstenberger BS, Roberts L, Benn CL, Grimley RL, Braam MJ, Rossi FM, Sudol M, Brown PJ, Bunnage ME, Owen DR, Zaph C, Vedadi M, Arrowsmith CHProc. Natl. Acad. Sci. U.S.A.10.1073/pnas.140735811118.08.2014
25136070ACVR1 mutations in DIPG: lessons learned from FOP.Taylor, KR; Vinci, M; Bullock, AN; Jones, C; 74:4565-4570Cancer Research10.1158/0008-5472.CAN-14-129801.9.2014
25122640Lost but making progress--Where will new analgesic drugs come from?Borsook, D; Hargreaves, R; Bountra, C; Porreca, F; 6:249sr3-Science Translational Medicine10.1126/scitranslmed.300832001.8.2014
Optimizing in vivo probes for the BET bromodomainsJennings, LE; Hewings, DS; Humphreys, PG; Brennan, PE; Conway, SJ; 248:-ACS National Meeting Book of Abstracts10.8.2014
25113945Recently targeted kinases and their inhibitors-the path to clinical trials.Knapp, S; Sundström, M; 17:58-63Current Opinion in Pharmacology10.1016/j.coph.2014.07.0159.8.2014
25101911Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants.Mohedas, AH; Wang, Y; Sanvitale, CE; Canning, P; Choi, S; Xing, X; Bullock, AN; Cuny, GD; Yu, PB; 57:7900-7915Journal of Medicinal Chemistry10.1021/jm501177w01.10.2014
25109876Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states.Dürr, KL; Chen, L; Stein, RA; De Zorzi, R; Folea, IM; Walz, T; Mchaourab, HS; Gouaux, E; 158:778-792Cell10.1016/j.cell.2014.07.0237.8.2014
25090614Synergistic effects of ethanol and isopentenyl pyrophosphate on expansion of γδ T cells in synovial fluid from patients with arthritisLaurent AJ, Bindslev N, Johansson B, Berg L. 9(8):e103683PLoS One10.1371/journal.pone.010368304.08.2014
24673109Balance between activating NKG2D, DNAM-1, NKp44 and NKp46 and inhibitory CD94/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts.Nielsen N, Pascal V, Fasth AER, Sundstrom Y, Galsgaard ED, Ahern D, Andersen M, Baslund B, Bartels EM, Bliddal H, Feldmann M, Malmstrom V, Berg L, Spee P, Soderstrom K. 142(4):581-9Immunology.10.1111/imm.1227101.08.2014
24704859Building and exploring an integrated human kinase network: global organization and medical entry points.Colinge, J; César-Razquin, A; Huber, K; Breitwieser, FP; Májek, P; Superti-Furga, G; 107:113-127Journal of Proteomics10.1016/j.jprot.2014.03.02801.7.2014
25049398Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor.Carr, SM; Munro, S; Zalmas, L-P; Fedorov, O; Johansson, C; Krojer, T; Sagum, CA; Bedford, MT; Oppermann, U; La Thangue, NB; 111:11341-11346Proceedings of the National Academy of Sciences10.1073/pnas.140373711101.8.2014
24804581Evaluating the promiscuous nature of tyrosine kinase inhibitors assessed in A431 epidermoid carcinoma cells by both chemical- and phosphoproteomics.Giansanti, P; Preisinger, C; Huber, KVM; Gridling, M; Superti-Furga, G; Bennett, KL; Heck, AJR; 9:1490-1498ACS Chemical Biology10.1021/cb500116c01.7.2014
25036311Corrigendum: Dual kinase-bromodomain inhibitors for rationally designed polypharmacology.Ciceri, P; Müller, S; O'Mahony, A; Fedorov, O; Filippakopoulos, P; Hunt, JP; Lasater, EA; Pallares, G; Picaud, S; Wells, C; Martin, S; Wodicka, LM; Shah, NP; Treiber, DK; Knapp, S; 10:692-Nature Chemical Biology10.1038/nchembio0814-692d01.7.2014
25032507Discovery of a Selective, Substrate-competitive Inhibitor of the Lysine Methyltransferase SETD8.Ma A, Yu W, Li F, Bleich RM, Herold JM, Butler KV, Norris JL, Korboukh V, Tripathy A, Janzen WP, Arrowsmith CH, Frye SV, Vedadi M, Brown PJ, Jin JJ. Med. Chem.10.1021/jm500871s17.07.2014
25042802A Methylation-Phosphorylation Switch Determines Sox2 Stability and Function in ESC Maintenance or Differentiation.Fang L, Zhang L, Wei W, Jin X, Wang P, Tong Y, Li J, Du JX, Wong JMol. Cell10.1016/j.molcel.2014.06.01816.07.2014
25097667Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching.Philpott, M; Rogers, CM; Yapp, C; Wells, C; Lambert, J-P; Strain-Damerell, C; Burgess-Brown, NA; Gingras, A-C; Knapp, S; Müller, S; 7:14-Epigenetics and Chromatin10.1186/1756-8935-7-1401.1.2014
24981860Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.Marcon E, Ni Z, Pu S, Turinsky AL, Trimble SS, Olsen JB, Silverman-Gavrila R, Silverman-Gavrila L, Phanse S, Guo H, Zhong G, Guo X, Young P, Bailey S, Roudeva D, Zhao D, Hewel J, Li J, Gräslund S, Paduch M, Kossiakoff AA, Lupien M, Emili A, Wodak SJ, Greenblatt J8(1):297-310Cell Rep10.1016/j.celrep.2014.05.05010.07.2014
25017071Bromodomain protein BRD4 is required for estrogen receptor-dependent enhancer activation and gene transcription.Nagarajan, S; Hossan, T; Alawi, M; Najafova, Z; Indenbirken, D; Bedi, U; Taipaleenmäki, H; Ben-Batalla, I; Scheller, M; Loges, S; Knapp, S; Hesse, E; Chiang, C-M; Grundhoff, A; Johnsen, SA; 8:460-469Cell Reports10.1016/j.celrep.2014.06.01610.7.2014
25010373A scintillation proximity assay for histone demethylases.Yu W, Eram MS, Hajian T, Szykowska A, Burgess-Brown N, Vedadi M, Brown PJAnal. Biochem.10.1016/j.ab.2014.06.02308.07.2014
24997600RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.Ni Z, Xu C, Guo X, Hunter GO, Kuznetsova OV, Tempel W, Marcon E, Zhong G, Guo H, Kuo WH, Li J, Young P, Olsen JB, Wan C, Loppnau P, El Bakkouri M, Senisterra GA, He H, Huang H, Sidhu SS, Emili A, Murphy S, Mosley AL, Arrowsmith CH, Min J, Greenblatt JFNat. Struct. Mol. Biol.10.1038/nsmb.285306.07.2014
25458521Expanding the clinical and molecular spectrum of thiamine pyrophosphokinase deficiency: a treatable neurological disorder caused by TPK1 mutations.Banka, S; de Goede, C; Yue, WW; Morris, AAM; von Bremen, B; Chandler, KE; Feichtinger, RG; Hart, C; Khan, N; Lunzer, V; Mataković, L; Marquardt, T; Makowski, C; Prokisch, H; Debus, O; Nosaka, K; Sonwalkar, H; Zimmermann, FA; Sperl, W; Mayr, JA; 113:301-306Molecular Genetics and Metabolism10.1016/j.ymgme.2014.09.01001.12.2014
24798337Human UTY(KDM6C) is a male-specific N-methyl lysyl demethylase.Walport LJ,Hopkinson RJ,Vollmar M,Madden SK,Gileadi C,Oppermann U,Schofield CJ,Johansson C. 289(26):18302-18313The Journal of biological chemistryhttp://dx.doi.org/10.1074/jbc.M114.555052 27/06/2014
24878222Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors.Storer, RI; Brennan, PE; Brown, AD; Bungay, PJ; Conlon, KM; Corbett, MS; DePianta, RP; Fish, PV; Heifetz, A; Ho, DKH; Jessiman, AS; McMurray, G; de Oliveira, CAF; Roberts, LR; Root, JA; Shanmugasundaram, V; Shapiro, MJ; Skerten, M; Westbrook, D; Wheeler, S; Whitlock, GA; Wright, J; 57:5258-5269Journal of Medicinal Chemistry10.1021/jm500329217.6.2014
24965881Selective tumor necrosis factor receptor I blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor II in collagen-induced arthritis.McCann, FE; Perocheau, DP; Ruspi, G; Blazek, K; Davies, ML; Feldmann, M; Dean, JLE; Stoop, AA; Williams, RO; 66:2728-2738Arthritis and Rheumatology10.1002/art.3875501.10.2014
24730530Exploration of type II binding mode: A privileged approach for kinase inhibitor focused drug discovery?Zhao, Z; Wu, H; Wang, L; Liu, Y; Knapp, S; Liu, Q; Gray, NS; 9:1230-1241ACS Chemical Biology10.1021/cb500129t01.6.2014
24669831An inhibitor's-eye view of the ATP-binding site of CDKs in different regulatory states.Echalier, A; Hole, AJ; Lolli, G; Endicott, JA; Noble, MEM; 9:1251-1256ACS Chemical Biology10.1021/cb500135f01.6.2014
24946055Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains.Hay, DA; Fedorov, O; Martin, S; Singleton, DC; Tallant, C; Wells, C; Picaud, S; Philpott, M; Monteiro, OP; Rogers, CM; Conway, SJ; Rooney, TPC; Tumber, A; Yapp, C; Filippakopoulos, P; Bunnage, ME; Müller, S; Knapp, S; Schofield, CJ; Brennan, PE; 136:9308-9319Journal of the American Chemical Society10.1021/ja412434f01.7.2014
24927729STRUCTURAL CHARACTERIZATION OF HUMAN CHOLESTEROL 7α-HYDROXYLASE.Tempel W, Grabovec I, MacKenzie F, Dichenko YV, Usanov SA, Gilep AA, Park HW, Strushkevich NJ. Lipid Res.10.1194/jlr.M05076513.06.2014
24915177A comparison of protein kinases inhibitor screening methods using both enzymatic activity and binding affinity determination.Rudolf, AF; Skovgaard, T; Knapp, S; Jensen, LJ; Berthelsen, J; 9:e98800-PLoS ONE10.1371/journal.pone.009880001.1.2014
24875736Cargo recognition and trafficking in selective autophagy.Stolz A, Ernst A, Dikic I.16(6):495-501Nat Cell Biol10.1038/ncb297901.06.2014
24814345Ribosomal oxygenases are structurally conserved from prokaryotes to humans.Chowdhury, R; Sekirnik, R; Brissett, NC; Krojer, T; Ho, C-H; Ng, SS; Clifton, IJ; Ge, W; Kershaw, NJ; Fox, GC; Muniz, JRC; Vollmar, M; Phillips, C; Pilka, ES; Kavanagh, KL; von Delft, F; Oppermann, U; McDonough, MA; Doherty, AJ; Schofield, CJ; 510:422-426Nature10.1038/nature1326319.6.2014
25078130What is the future of bromodomains in targeted drug development?F, O; e, ; d, ; o, ; r, ; o, ; v, ; 6:1101-1103Future Medicinal Chemistry10.4155/fmc.14.6401.6.2014
CHROMATIN MODIFYING MECHANISMS IN MACROPHAGES DIFFER BETWEEN HEALTHY CONTROLS AND PATIENTS WIH RHEUMATOID ARTHRITISRooke, K; Kruidenier, L; Che, H; Mander, P; Swales, C; Prinjha, R; Oppermann, U; 73:823-824Annals of the Rheumatic Diseases10.1136/annrheumdis-2014-eular.421801.6.2014
24555901Structure and function of MPN (Mpr1/Pad1 N-terminal) domain-containing proteins.Birol, M; Echalier, A; 15:504-517Current Protein and Peptide Science10.2174/138920371566614022109510901.1.2014
24853335Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1.Qin S, Liu Y, Tempel W, Eram MS, Bian C, Liu K, Senisterra G, Crombet L, Vedadi M, Min J5:3952Nat Commun10.1038/ncomms495224.05.2014
24821300A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation-π interaction.Rooney, TPC; Filippakopoulos, P; Fedorov, O; Picaud, S; Cortopassi, WA; Hay, DA; Martin, S; Tumber, A; Rogers, CM; Philpott, M; Wang, M; Thompson, AL; Heightman, TD; Pryde, DC; Cook, A; Paton, RS; Müller, S; Knapp, S; Brennan, PE; Conway, SJ; 53:6126-6130Angewandte Chemie International Edition10.1002/anie.20140275001.6.2014
24814345Ribosomal oxygenases are structurally conserved from prokaryotes to humans.Chowdhury, R; Sekirnik, R; Brissett, NC; Krojer, T; Ho, CH; Ng, SS; Clifton, IJ; Ge, W; Kershaw, NJ; Fox, GC; Muniz, JR; Vollmar, M; Phillips, C; Pilka, ES; Kavanagh, KL; von Delft, F; Oppermann, U; McDonough, MA; Doherty, AJ; Schofield, CJ; 510:422-426Nature10.1038/nature1326319.6.2014
24726327Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling.Schaeffer V, Akutsu M, Olma MH, Gomes LC, Kawasaki M, Dikic I.54(3):349-61Mol Cell10.1016/j.molcel.2014.03.01608.05.2014
24813610A Chromatin-Dependent Role of the Fragile X Mental Retardation Protein FMRP in the DNA Damage Response.Alpatov R, Lesch BJ, Nakamoto-Kinoshita M, Blanco A, Chen S, Stützer A, Armache KJ, Simon MD, Xu C, Ali M, Murn J, Prisic S, Kutateladze TG, Vakoc CR, Min J, Kingston RE, Fischle W, Warren ST, Page DC, Shi Y157(4):869-81Cell10.1016/j.cell.2014.03.04008.05.2014
24704254Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases.Trésaugues L, Silvander C, Flodin S, Welin M, Nyman T, Gräslund S, Hammarström M, Berglund H, Nordlund P22(5):744-55Structure10.1016/j.str.2014.01.01306.05.2014
24798337Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase.Walport, LJ; Hopkinson, RJ; Vollmar, M; Madden, SK; Gileadi, C; Oppermann, U; Schofield, CJ; Johansson, C; 289:18302-18313Journal of Biological Chemistry10.1074/jbc.M114.55505201.6.2014
Recurrent activating ACVR1 mutations in diffuse intrinsic pontine gliomaTaylor, KR; Mackay, A; Truffaux, N; Butterfield, YS; Morozova, O; Philippe, C; Castel, D; Grasso, CS; Vinci, M; Carvalho, D; Carcaboso, AM; de Torres, C; Cruz, O; Mora, J; Entz-Werle, N; Ingram, WJ; Monje, M; Hargrave, D; Bullock, AN; Puget, S; Yip, S; Jones, C; Grill, J; 46:457-461Nature Genetics10.1038/ng.292501.5.2014
24670415Inhibition of NAD+-dependent histone deacetylases (sirtuins) causes growth arrest and activates both apoptosis and autophagy in the pathogenic protozoan Trypanosoma cruzi.Veiga-Santos, P; Reignault, LC; Huber, K; Bracher, F; De Souza, W; De Carvalho, TMU; 141:814-825Parasitology10.1017/s003118201300170401.5.2014
24778178Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single stranded m6A RNA demethylation.Xu C, Liu K, Tempel W, Demetriades M, Aik W, Schofield CJ, Min JJ. Biol. Chem.10.1074/jbc.M114.55035028.04.2014
24751816Targeting bromodomains: epigenetic readers of lysine acetylation.Filippakopoulos, P; Knapp, S; 13:337-356Nature Reviews Drug Discovery10.1038/nrd428601.5.2014
24768818Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors.Canning, P; Tan, L; Chu, K; Lee, SW; Gray, NS; Bullock, AN; 426:2457-2470Journal of Molecular Biology10.1016/j.jmb.2014.04.01401.6.2014
24732914Modulation of the chromatin phosphoproteome by the Haspin protein kinase.Maiolica, A; de Medina-Redondo, M; Schoof, EM; Chaikuad, A; Villa, F; Gatti, M; Jeganathan, S; Lou, HJ; Novy, K; Hauri, S; Toprak, UH; Herzog, F; Meraldi, P; Penengo, L; Turk, BE; Knapp, S; Linding, R; Aebersold, R; 13:1724-1740Molecular and Cellular Proteomics10.1074/mcp.M113.03481901.7.2014
24717435Copper is required for oncogenic BRAF signalling and tumorigenesis.Brady, DC; Crowe, MS; Turski, ML; Hobbs, GA; Yao, X; Chaikuad, A; Knapp, S; Xiao, K; Campbell, SL; Thiele, DJ; Counter, CM; 509:492-496Nature10.1038/nature1318001.5.2014
24697329Enzymatic and structural characterization of rTSγ provides insights into the function of rTSβ.Wichelecki, DJ; Froese, DS; Kopec, J; Muniz, JRC; Yue, WW; Gerlt, JA; 53:2732-2738Biochemistry10.1021/bi500349e15.4.2014
24704322Epigenetic targets and drug discovery: Part 1: Histone methylation.Liu Y, Liu K, Qin S, Xu C, Min JPharmacol. Ther.10.1016/j.pharmthera.2014.03.00702.04.2014
24695225Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.Huber, KVM; Salah, E; Radic, B; Gridling, M; Elkins, JM; Stukalov, A; Jemth, A-S; Göktürk, C; Sanjiv, K; Strömberg, K; Pham, T; Berglund, UW; Colinge, J; Bennett, KL; Loizou, JI; Helleday, T; Knapp, S; Superti-Furga, G; 508:222-227Nature10.1038/nature131942.4.2014
24619026Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinases.Ekambaram, R; Enkvist, E; Manoharan, GB; Ugandi, M; Kasari, M; Viht, K; Knapp, S; Issinger, O-G; Uri, A; 50:4096-4098Chemical Communications10.1039/c3cc49198f01.4.2014
24649957Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases.Cowan-Jacob, SW; Jahnke, W; Knapp, S; 6:541-561Future Medicinal Chemistry10.4155/fmc.13.21601.4.2014
EPIGENETIC MODIFYING COMPOUNDS ALTER ACTIVITY OF PRIMARY HUMAN ARTICULAR CHONDROCYTES AND MESENCHYMAL STEM CELLS UNDERGOING CHONDROGENESISSnelling, S; Kramm, A; Yapp, C; Carr, A; Oppermann, U; 22:S141-S141Osteoarthritis and Cartilage10.1016/j.joca.2014.02.26001.4.2014
Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatographyGuetzoyan, L; Ingham, RJ; Nikbin, N; Rossignol, J; Wolling, M; Baumert, M; Burgess-Brown, NA; Strain-Damerell, CM; Shrestha, L; Brennan, PE; Fedorov, O; Knapp, S; Ley, SV; 5:540-546MedChemComm10.1039/c4md00007b01.4.2014
24497639Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1.Jung, M; Philpott, M; Müller, S; Schulze, J; Badock, V; Eberspächer, U; Moosmayer, D; Bader, B; Schmees, N; Fernández-Montalván, A; Haendler, B; 289:9304-9319Journal of Biological Chemistry10.1074/jbc.M113.52301901.3.2014
24648452Protein ISGylation delays but does not overcome coronavirus proliferation in a model of fulminant hepatitis.Ma XZ, Bartczak A, Zhang J, He W, Shalev I, Smil D, Chen L, Phillips J, Feld JJ, Selzner N, Levy G, McGilvray IJ. Virol.10.1128/JVI.03801-1319.03.2014
24641320Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation.Schumacher, F-R; Sorrell, FJ; Alessi, DR; Bullock, AN; Kurz, T; 460:237-246Biochemical Journal10.1042/BJ2014015301.6.2014
24634223Trimethylation of Histone H3 Lysine 36 by Human Methyltransferase PRDM9.Eram MS, Bustos SP, Lima-Fernandes E, Siarheyeva A, Senisterra G, Hajian T, Chau I, Duan S, Wu H, Dombrovski L, Schapira M, Arrowsmith CH, Vedadi MJ. Biol. Chem.10.1074/jbc.M113.52318314.03.2014
24616105Crystal Structures of Human RNA Demethylase Alkbh5 Reveal Basis for Substrate Recognition.Feng C, Liu Y, Wang G, Deng Z, Zhang Q, Wu W, Tong Y, Cheng C, Chen ZJ. Biol. Chem.10.1074/jbc.M113.54616810.03.2014
24590706Structural genomics of human proteins.Osman KT, Edwards A1140:27-34Methods Mol. Biol.10.1007/978-1-4939-0354-2_205.03.2014
24590718Salvage or recovery of failed targets by in situ proteolysis.Tong Y, Dong A, Xu X, Wernimont A1140:179-88Methods Mol. Biol.10.1007/978-1-4939-0354-2_1405.03.2014
24595546A Basic Post-SET Extension of NSDs Is Essential for Nucleosome Binding In Vitro.Allali-Hassani A, Kuznetsova E, Hajian T, Wu H, Dombrovski L, Li Y, Gräslund S, Arrowsmith CH, Schapira M, Vedadi MJ Biomol Screen10.1177/108705711452585404.03.2014
24584101Dual kinase-bromodomain inhibitors for rationally designed polypharmacology.Ciceri, P; Müller, S; O'Mahony, A; Fedorov, O; Filippakopoulos, P; Hunt, JP; Lasater, EA; Pallares, G; Picaud, S; Wells, C; Martin, S; Wodicka, LM; Shah, NP; Treiber, DK; Knapp, S; 10:305-312Nature Chemical Biology10.1038/nchembio.147101.4.2014
Discovery of BET bromodomain inhibitors and their role in target validationMueller, S; Knapp, S; 5:288-296MedChemComm10.1039/c3md00291h01.3.2014
25125334Functional characterization and categorization of missense mutations that cause methylmalonyl-CoA mutase (MUT) deficiency.Forny, P; Froese, DS; Suormala, T; Yue, WW; Baumgartner, MR; 35:1449-1458Human Mutation10.1002/humu.2263301.12.2014
A new way to interrogate PTPsVan Ameijde, J; Overvoorde, J; Knapp, S; Den Hertog, J; Ruijtenbeek, R; Liskamp, RM; 12:105-106ASSAY and Drug Development Technologies10.1089/adt.2014.1202.lr1.3.2014
24549042Mutation or knock-down of 17β-hydroxysteroid dehydrogenase type 10 cause loss of MRPP1 and impaired processing of mitochondrial heavy strand transcripts.Deutschmann, AJ; Amberger, A; Zavadil, C; Steinbeisser, H; Mayr, JA; Feichtinger, RG; Oerum, S; Yue, WW; Zschocke, J; 23:3618-3628Human Molecular Genetics10.1093/hmg/ddu0721.7.2014
24583601A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity.Ablett, MP; O'Brien, CS; Sims, AH; Farnie, G; Clarke, RB; 5:599-612Oncotarget10.18632/oncotarget.116901.2.2014
24527812Correction to Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor.Kim, HG; Tan, L; Weisberg, EL; Liu, F; Canning, P; Choi, HG; Ezell, S; Zhao, Z; Wu, H; Wang, J; Mandinova, A; Bullock, AN; Liu, Q; Lee, SW; Gray, NS; 9:840-ACS Chemical Biology10.1021/cb500094921.3.2014
24900801Discovery and development of potent and selective inhibitors of histone methyltransferase g9a.Sweis RF, Pliushchev M, Brown PJ, Guo J, Li F, Maag D, Petros AM, Soni NB, Tse C, Vedadi M, Michaelides MR, Chiang GG, Pappano WN5(2):205-9ACS Med Chem Lett10.1021/ml400496h13.02.2014
24507377EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial.Rice, ASC; Dworkin, RH; McCarthy, TD; Anand, P; Bountra, C; McCloud, PI; Hill, J; Cutter, G; Kitson, G; Desem, N; Raff, M; EMA401-003 study group, ; 383:1637-1647Lancet10.1016/S0140-6736(13)62337-510.5.2014
24450636Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development.Gileadi, O;42:108-113Biochemical Society Transactions10.1042/BST2013022801.2.2014
24450640Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition.Cooper, CDO; Newman, JA; Gileadi, O; 42:130-138Biochemical Society Transactions10.1042/BST2013022701.2.2014
24335142Tumor microenvironment-associated modifications of alternative splicingBrosseau, J-P, Lucier, J-F, Nwilati, H, Thibault, P, Garneau, D, Durand, M, Couture, S, Lapointe, E, Prinos, P, Klinck, R, Perreault, J-P, Chabot, B, Abou-Elela, S.20(2):189-201RNA10.1261/rna.04216802.2014
24247151Lapatinib inhibits stem/progenitor proliferation in preclinical in vitro models of ductal carcinoma in situ (DCIS).Farnie, G; Johnson, RL; Williams, KE; Clarke, RB; Bundred, NJ; 13:418-425Cell Cycle10.4161/cc.2720101.1.2014
24579949The roles of Jumonji-type oxygenases in human disease.Johansson, C; Tumber, A; Che, K; Cain, P; Nowak, R; Gileadi, C; Oppermann, U; 6:89-120Epigenomics10.2217/epi.13.7901.2.2014
24450635New strategies to inhibit KEAP1 and the Cul3-based E3 ubiquitin ligases.Canning, P; Bullock, AN; 42:103-107Biochemical Society Transactions10.1042/BST2013021501.2.2014
24470271Structural characterization of a new N-substituted pantothenamide bound to pantothenate kinases from Klebsiella pneumonia and Staphylococcus aureus.Hughes SJ, Antoshchenko T, Kim KP, Smil D, Park HWProteins10.1002/prot.2452428.01.2014
24466405The structure-activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface.Camerino MA, Zhong N, Dong A, Dickson BM, James LI, Baughman BM, Norris JL, Kireev DB, Janzen WP, Arrowsmith CH, Frye SV4(11):1501-1507Medchemcomm10.1039/C3MD00197K28.01.2014
Electrostatically Enhanced Association of a Pim Kinase Substrate Revealed by Stochastic DetectionHarrington, L; Cheley, S; Alexander, LT; Knapp, S; Bayley, H; 106:18A-18ABiophysical Journal10.1016/j.bpj.2013.11.15328.1.2014
24469824OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis.Gwyer Findlay, E; Danks, L; Madden, J; Cavanagh, MM; McNamee, K; McCann, F; Snelgrove, RJ; Shaw, S; Feldmann, M; Taylor, PC; Horwood, NJ; Hussell, T; 111:2289-2294Proceedings of the National Academy of Sciences10.1073/pnas.132107111101.2.2014
24459181The structural basis of PI3K cancer mutations: from mechanism to therapy.Liu, S; Knapp, S; Ahmed, AA; 74:641-646Cancer Research10.1158/0008-5472.CAN-13-23191.2.2014
24359314Diverse levels of sequence selectivity and catalytic efficiency of protein-tyrosine phosphatasesSelner, NG; Luechapanichkul, R; Chen, X; Neel, BG; Zhang, ZY; Knapp, S; Bell, CE; Pei, D; 53:397-412Biochemistry10.1021/bi401223r21.1.2014
24443078A Chemical Tool for In Vitro and In Vivo Precipitation of Lysine Methyltransferase G9a.Konze KD, Pattenden SG, Liu F, Barsyte-Lovejoy D, Li F, Simon JM, Davis IJ, Vedadi M, Jin JChemMedChem10.1002/cmdc.20130045017.01.2014
24438162Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies.Chaikuad, A; Keates, T; Vincke, C; Kaufholz, M; Zenn, M; Zimmermann, B; Gutiérrez, C; Zhang, R-G; Hatzos-Skintges, C; Joachimiak, A; Muyldermans, S; Herberg, FW; Knapp, S; Müller, S; 459:59-69Biochemical Journal10.1042/BJ2013139901.4.2014
Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9aSweis RF, Pliushchev M, Brown PJ, Guo J, Li F, Maag D, Petros AM, Soni NB, Tse C, Vedadi M, Michaelides MR, Chiang GG, PappanoWNACS Med. Chem. Lett04.01.2014
24203324Medium-throughput production of recombinant human proteins: ligation-independent cloning.Strain-Damerell, C; Mahajan, P; Gileadi, O; Burgess-Brown, NA; 1091:55-72Methods in Molecular Biology10.1007/978-1-62703-691-7_401.01.2014
24203326Medium-throughput production of recombinant human proteins: protein production in insect cells.Mahajan, P; Strain-Damerell, C; Gileadi, O; Burgess-Brown, NA; 1091:95-121Methods in Molecular Biology10.1007/978-1-62703-691-7_601.01.2014
BROMODOMAIN INHIBITORS REDUCE TH17-TYPE RESPONSES IN SPONDYLOARTHRITIS IN VITROHammitzsch, A; de Wit, J; Ridley, A; Al-Mossawi, MH; Knapp, S; Bowness, P; 32:810-810Clinical and Experimental Rheumatology01.01.2014
The global cancer genomics consortium’s third annual symposium: From oncogenomics to cancer careCosta, L; Casimiro, S; Gupta, S; Knapp, S; Pillai, MR; Toi, M; Badwe, R; Carmo-Fonseca, M; Kumar, R; 5:64-70Genes and Cancer1.1.2014
24590728Case study--structural genomics and human protein kinases.E, J; l, M; k, ; i, ; n, ; s, ; 1140:325-336Methods in Molecular Biology10.1007/978-1-4939-0354-2_2401.01.2014
24283969Seeding collaborations to advance kinase science with the GSK Published Kinase Inhibitor Set (PKIS)Drewry DH, Willson TM, Zuercher WJ.14(3):340-2Curr Top Med Chem2014
24378531TNFR2 increases the sensitivity of ligand-induced activation of the p38 MAPK and NF-κB pathways and signals TRAF2 protein degradation in macrophages.Ruspi, G; Schmidt, EM; McCann, F; Feldmann, M; Williams, RO; Stoop, AA; Dean, JLE; 26:683-690Cellular Signalling10.1016/j.cellsig.2013.12.00901.4.2014
24374310Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity.Chen, C; Ha, BH; Thévenin, AF; Lou, HJ; Zhang, R; Yip, KY; Peterson, JR; Gerstein, M; Kim, PM; Filippakopoulos, P; Knapp, S; Boggon, TJ; Turk, BE; 53:140-147Molecular Cell10.1016/j.molcel.2013.11.0139.1.2014
24313754[1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains.Fedorov, O; Lingard, H; Wells, C; Monteiro, OP; Picaud, S; Keates, T; Yapp, C; Philpott, M; Martin, SJ; Felletar, I; Marsden, BD; Filippakopoulos, P; Müller, S; Knapp, S; Brennan, PE; 57:462-476Journal of Medicinal Chemistry10.1021/jm401568s01.1.2014
243042388-Substituted O(6)-cyclohexylmethylguanine CDK2 inhibitors: using structure-based inhibitor design to optimize an alternative binding mode.Carbain, B; Paterson, DJ; Anscombe, E; Campbell, AJ; Cano, C; Echalier, A; Endicott, JA; Golding, BT; Haggerty, K; Hardcastle, IR; Jewsbury, PJ; Newell, DR; Noble, MEM; Roche, C; Wang, LZ; Griffin, RJ; 57:56-70Journal of Medicinal Chemistry10.1021/jm401555v01.1.2014
24309020A versatile spectrophotometric protein tyrosine phosphatase assay based on 3-nitrophosphotyrosine containing substrates.van Ameijde, J; Overvoorde, J; Knapp, S; den Hertog, J; Ruijtenbeek, R; Liskamp, RMJ; 448:9-13Analytical Biochemistry10.1016/j.ab.2013.11.0231.3.2014
24705252Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma.Taylor, KR; Mackay, A; Truffaux, N; Butterfield, Y; Morozova, O; Philippe, C; Castel, D; Grasso, CS; Vinci, M; Carvalho, D; Carcaboso, AM; de Torres, C; Cruz, O; Mora, J; Entz-Werle, N; Ingram, WJ; Monje, M; Hargrave, D; Bullock, AN; Puget, S; Yip, S; Jones, C; Grill, J; 46:457-461Nature Genetics10.1038/ng.292501.5.2014
23934193Pleiotropic effect of somatic mutations in the E2F subunit DP-1 gene in human cancer.Munro, S; Oppermann, U; La Thangue, NB; 33:3594-3603Oncogene10.1038/onc.2013.3163.7.2014
22610134The role of protein structural analysis in the next generation sequencing era.Yue, WW; Froese, DS; Brennan, PE; 336:67-98Topics in Current Chemistry10.1007/128_2012_32601.01.2014
24367611Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations.Wu H, Zeng H, Dong A, Li F, He H, Senisterra G, Seitova A, Duan S, Brown PJ, Vedadi M, Arrowsmith CH, Schapira M8(12):e83737PLoS ONE10.1371/journal.pone.008373719.12.2013
24319001ChromoHub V2: Cancer Genomics.Shah MA, Denton EL, Liu L, Schapira MBioinformatics10.1093/bioinformatics/btt71006.12.2013
24162852Neculai D, Schwake M, Ravichandran M, Zunke F, Collins RF, Peters J, Neculai M, Plumb J, Loppnau P, Pizarro JC, Seitova A, Trimble WS, Saftig P, Grinstein S, Dhe-Paganon S.Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36.504(7478):172-176Nature10.1038/nature1268405.12.2013
24304323Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain.Ferguson, FM; Fedorov, O; Chaikuad, A; Philpott, M; Muniz, JRC; Felletar, I; von Delft, F; Heightman, T; Knapp, S; Abell, C; Ciulli, A; 56:10183-10187Journal of Medicinal Chemistry10.1021/jm401582c13.12.2013
24239623Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-onesDeng, X; Elkins, JM; Zhang, J; Yang, Q; Erazo, T; Gomez, N; Choi, HG; Wang, J; Dzamko, N; Lee, JD; Sim, T; Kim, N; Alessi, DR; Lizcano, JM; Knapp, S; Gray, NS; 70:758-767European Journal of Medicinal Chemistry10.1016/j.ejmech.2013.10.0521.1.2013
23906694Fragment-based hit identification: thinking in 3DMorley, AD; Pugliese, A; Birchall, K; Bower, J; Brennan, P; Brown, N; Chapman, T; Drysdale, M; Gilbert, IH; Hoelder, S; Jordan, A; Ley, SV; Merritt, A; Miller, D; Swarbrick, ME; Wyatt, PG; 18:1221-1227Drug Discovery Today10.1016/j.drudis.2013.07.01101.12.2013
24396869Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2.Wu H, Siarheyeva A, Zeng H, Lam R, Dong A, Wu XH, Li Y, Schapira M, Vedadi M, Min J587(23):3859-68FEBS Lett.10.1016/j.febslet.2013.10.02029.11.2013
Structural insights into functional overlapping and differentiation among myosin V motorsNascimento, AFZ; Trindade, DM; Tonoli, CCC; De Giuseppe, PO; Assis, LHP; Honorato, RV; Deoliveira, PSL; Mahajan, P; Burgess-Brown, NA; Von Delft, F; Larson, RE; Murakami, MT; 288:34131-34145Journal of Biological Chemistry10.1074/jbc.M113.50720222.11.2013
24248379RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain.Picaud, S; Wells, C; Felletar, I; Brotherton, D; Martin, S; Savitsky, P; Diez-Dacal, B; Philpott, M; Bountra, C; Lingard, H; Fedorov, O; Müller, S; Brennan, PE; Knapp, S; Filippakopoulos, P; 110:19754-19759Proceedings of the National Academy of Sciences10.1073/pnas.131065811001.12.2013
24115519Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactionsSchäfer, G; Milic̈, J; Eldahshan, A; Götz, F; Zühlke, K; Schillinger, C; Kreuchwig, A; Elkins, JM; Abdulazeez, KR; Oder, A; Moutty, MC; Masada, N; Beerbaum, M; Schlegel, B; Niquet, S; Schmieder, P; Krause, G; Vonkries, JP; Cooper, DMF; Knapp, S; Rademann, J; Rosenthal, W; Klussmann, E; 52:12187-12191Angewandte Chemie International Edition10.1002/anie.20130468611.11.2013
24203325Medium-Throughput Production of Recombinant Human Proteins: Protein Production in E. coli.Burgess-Brown NA, Mahajan P, Strain-Damerell C, Gileadi O, Gräslund S1091:73-94Methods Mol. Biol.10.1007/978-1-62703-691-7_510.11.2013
24285704Maintenance of muscle myosin levels in adult C. elegans requires both the double bromodomain protein BET-1 and sumoylation.Fisher, K; Gee, F; Wang, S; Xue, F; Knapp, S; Philpott, M; Wells, C; Rodriguez, M; Snoek, LB; Kammenga, J; Poulin, GB; 2:1354-1363Biology Open10.1242/bio.2013600715.12.2013
24195502Mutant prolactin receptor and familial hyperprolactinemiaNewey, PJ; Gorvin, CM; :-New England Journal of Medicine10.1056/NEJMoa13075576.11.2013
24194548Stochastic detection of Pim protein kinases reveals electrostatically enhanced association of a peptide substrate.Harrington, L; Cheley, S; Alexander, LT; Knapp, S; Bayley, H; 110:E4417-E4426Proceedings of the National Academy of Sciences10.1073/pnas.131273911019.11.2013
Structural genomics and drug discovery for chromatin-related protein complexes involved in histone tail recognitionFilippakopoulos, P; Knapp, S; :211-22510.1007/978-1-4614-7931-4_111.11.2013
Real-Time Monitoring of the Dephosphorylating Activity of Protein Tyrosine Phosphatases Using Microarrays with 3-Nitrophosphotyrosine Substratesvan Ameijde, J; Overvoorde, J; Knapp, S; den Hertog, J; Ruijtenbeek, R; Liskamp, RMJ; 78:1349-1357ChemPlusChem10.1002/cplu.20130029901.11.2013
Working together to identify new epigenetic targets for cancerBountra, C;12:-Molecular Cancer Therapeutics10.1158/1535-7163.TARG-13-PL03-0101.11.2013
24210219Biochemical and Structural Studies of Conserved Maf Proteins Revealed Nucleotide Pyrophosphatases with a Preference for Modified Nucleotides.Tchigvintsev A, Tchigvintsev D, Flick R, Popovic A, Dong A, Xu X, Brown G, Lu W, Wu H, Cui H, Dombrowski L, Joo JC, Beloglazova N, Min J, Savchenko A, Caudy AA, Rabinowitz JD, Murzin AG, Yakunin AFChem. Biol.10.1016/j.chembiol.2013.09.01122.10.2013
24147171Exploring the Trypanosoma brucei Hsp83 Potential as a Target for Structure Guided Drug Design.Pizarro JC, Hills T, Senisterra G, Wernimont AK, Mackenzie C, Norcross NR, Ferguson MA, Wyatt PG, Gilbert IH, Hui R7(10):e2492PLoS Negl Trop Dis10.1371/journal.pntd.000249217.10.2013
24127276Small-molecule modulators for epigenetics targets.Knapp, S; Weinmann, H; 8:1885-1891ChemMedChem10.1002/cmdc.20130034401.11.2013
24113749Identification of Novel Functionally Selective Kappa Opioid Receptor Scaffolds.White KL, Scopton AP, Rives ML, Bikbulatov RV, Polepally PR, Brown PJ, Kenakin T, Javitch JA, Zjawiony JK, Roth BLMol. Pharmacol.10.1124/mol.113.08964910.10.2013
24102134Discovery of an in vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP.Liu F, Barsyte-Lovejoy D, Li F, Xiong Y, Korboukh VK, Huang X, Allali-Hassani A, Janzen WP, Roth BL, Frye SV, Arrowsmith CH, Brown PJ, Vedadi M, Jin JJ. Med. Chem.10.1021/jm401480r08.10.2013
24090311Discovery of novel small-molecule inhibitors of BRD4 using structure-based virtual screening.Vidler, LR; Filippakopoulos, P; Fedorov, O; Picaud, S; Martin, S; Tomsett, M; Woodward, H; Brown, N; Knapp, S; Hoelder, S; 56:8073-8088Journal of Medicinal Chemistry10.1021/jm40113023.10.2013
24095733Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of PRDM9.Wu H, Mathioudakis N, Diagouraga B, Dong A, Dombrovski L, Baudat F, Cusack S, de Massy B, Kadlec JCell Rep10.1016/j.celrep.2013.08.03502.10.2013
Nuclear Receptor 4A2 Is Differentially Expressed In Animal Models Of RA During Inflammation and ResolutionEverett, J; McCann, FE; Palfreeman, AC; Shaw, AT; Gravallese, EM; Mix, KS; 65:S542-S542Arthritis and Rheumatism01.10.2013
24012121Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicaseRosenthal, AS; Dexheimer, TS; Jadhav, A; Simeonov, A; Maloney, DJ; Gileadi, O; Nguyen, GH; Hickson, ID; Chu, WK; :-Bioorganic and Medicinal Chemistry Letters10.1016/j.bmcl.2013.08.02501.01.2013
Identification of chromatin modifying mechanisms in human primary macrophages in an inflammatory modelRooke, K; Kruidenier, L; Che, K; Mander, P; Swales, C; Prinjha, R; Oppermann, U; 94:A17-A17International Journal of Experimental Pathology01.10.2013
Epigenetic modifying compounds alter activity of primary human articular chondrocytes and mesenchymal stem cells undergoing chondrogenesisSnelling, SJB; Kramm, A; Cain, P; Yapp, C; Carr, AJ; Oppermann, U; 94:A16-A16International Journal of Experimental Pathology01.10.2013
An epigenetic screen identifies bromodomain-containing protein 4 (BRD4) as a critical component for osteoblast differentiationKramm, A; Kubicek, S; Dunford, JE; Oppermann, U; 94:A18-A18International Journal of Experimental Pathology01.10.2013
Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1De Nicola, GF; Martin, ED; Chaikuad, A; Bassi, R; Clark, J; Martino, L; Verma, S; Sicard, P; Tata, R; Atkinson, RA; Knapp, S; Conte, MR; Marber, MS; 20:1182-1192Nature Structural and Molecular Biology10.1038/nsmb.26681.10.2013
24082136Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation.Islam K, Chen Y, Wu H, Bothwell IR, Blum GJ, Zeng H, Dong A, Zheng W, Min J, Deng H, Luo MProc. Natl. Acad. Sci. U.S.A.10.1073/pnas.121636511030.09.2013
24011590Functional proteomics defines the molecular switch underlying FGF receptor trafficking and cellular outputsFrancavilla C, Rigbolt KT, Emdal KB, Carraro G, Vernet E, Bekker-Jensen DB, Streicher W, Wikström M, Sundström M, Bellusci S, Cavallaro U, Blagoev B, Olsen JV.51(6):707-22Mol Cell.10.1016/j.molcel.2013.08.00226.09.2013
24076217Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1.Zheng, S; Moehlenbrink, J; Lu, Y-C; Zalmas, L-P; Sagum, CA; Carr, S; McGouran, JF; Alexander, L; Fedorov, O; Munro, S; Kessler, B; Bedford, MT; Yu, Q; La Thangue, NB; 52:37-51Molecular Cell10.1016/j.molcel.2013.08.03901.10.2013
23988329Previously unknown role for the ubiquitin ligase Ubr1 in endoplasmic reticulum-associated protein degradation.Stolz A, Besser S, Hottmann H, Wolf DH.110(38):15271-6Proc Natl Acad Sci U S A10.1073/pnas.130492811017.09.2013
23887803Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD.Gammons, MV; Fedorov, O; Ivison, D; Du, C; Clark, T; Hopkins, C; Hagiwara, M; Dick, AD; Cox, R; Harper, SJ; Hancox, JC; Knapp, S; Bates, DO; 54:6052-6062Investigative Ophthalmology & Visual Science10.1167/iovs.13-124225.9.2013
24041156Recent advances reveal IL-8 signaling as a potential key to targeting breast cancer stem cells.Singh, JK; Simões, BM; Howell, SJ; Farnie, G; Clarke, RB; 15:210-Breast Cancer Research10.1186/bcr343601.1.2013
3D Structure and Physiological Regulation of PAKsK, S; n, ; a, ; p, ; p, ; :137-14810.1016/B978-0-12-407198-8.00008-427.8.2013
23990909Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.Linossi, EM; Chandrashekaran, IR; Kolesnik, TB; Murphy, JM; Webb, AI; Willson, TA; Kedzierski, L; Bullock, AN; Babon, JJ; Norton, RS; Nicola, NA; Nicholson, SE; 8:e70536-PLoS ONE10.1371/journal.pone.007053601.01.2013
266820365-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocationHopkinson, RJ; Tumber, A; Yapp, C; Chowdhury, R; Aik, WS; Che, KH; Li, XS; Kristensen, JBL; King, ONF; Chan, MC; Yeoh, KK; Choi, H; Walport, LJ; Thinnes, CC; Bush, JT; Lejeune, C; Rydzik, AM; Rose, NR; Bagg, EA; McDonough, MA; Krojer, TJ; Yue, WW; Ng, SS; Olsen, L; Brennan, PE; Oppermann, U; Müller, S; Klose, RJ; Ratcliffe, PJ; Schofield, CJ; Kawamura, A; 4:3110-3117Chemical Science10.1039/c3sc51122g1.7.2013
23918227Testis specific gene expression drives disease progression and Rituximab resistance in lymphoma.K, S; n, ; a, ; p, ; p, ; 5:1149-1150EMBO Molecular Medicine10.1002/emmm.20130301801.8.2013
ELUCIDATING THE MOLECULAR MECHANISM OF ACTION OF CANCER DRUGS IN THE SECOND DECADE OF THE NEW MILLENNIUMSuperti-Furga, G; Winter, G; Bigenzahn, J; Radic, B; Colinge, J; Bennett, K; Kubicek, S; Zuber, J; Brummelkamp, T; Huber, K; 41:S9-S9Experimental Hematology10.1016/j.exphem.2013.05.03501.8.2013
23902751Experimental characterization of the human non-sequence-specific nucleic acid interactome.Dürnberger, G; Bürckstümmer, T; Huber, K; Giambruno, R; Doerks, T; Karayel, E; Burkard, TR; Kaupe, I; Müller, AC; Schönegger, A; Ecker, GF; Lohninger, H; Bork, P; Bennett, KL; Superti-Furga, G; Colinge, J; 14:R81-Genome Biology10.1186/gb-2013-14-7-r8101.1.2013
23899692Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor.Kim, H-G; Tan, L; Weisberg, EL; Liu, F; Canning, P; Choi, HG; Ezell, SA; Wu, H; Zhao, Z; Wang, J; Mandinova, A; Griffin, JD; Bullock, AN; Liu, Q; Lee, SW; Gray, NS; 8:2145-2150ACS Chemical Biology10.1021/cb400430t18.10.2013
23887803Topical anti-angiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative-AMD.Gammons MV, Federov O, Ivison D, Du C, Clark TL, Hopkins C, Hagiwara M, Dick AD, Cox RJ, Harper SJ, Hancox JC, Knapp S, Bates DOInvest. Ophthalmol. Vis. Sci.10.1167/iovs.13-1242225.07.2013
23850191Control of the Hippo Pathway by Set7-Dependent Methylation of Yap.Oudhoff MJ, Freeman SA, Couzens AL, Antignano F, Kuznetsova E, Min PH, Northrop JP, Lehnertz B, Barsyte-Lovejoy D, Vedadi M, Arrowsmith CH, Nishina H, Gold MR, Rossi FM, Gingras AC, Zaph CDev. Cell10.1016/j.devcel.2013.05.02509.07.2013
23823798Ionic strength-dependent conformations of a ubiquitin-like small archaeal modifier protein (SAMP2) from Haloferax volcanii.Liao S, Zhang W, Fan K, Ye K, Zhang X, Zhang J, Xu C, Tu X3:2136Sci Rep10.1038/srep0213605.07.2013
23827681OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.Mevissen TE, Hospenthal MK, Geurink PP, Elliott PR, Akutsu M, Arnaudo N, Ekkebus R, Kulathu Y, Wauer T, El Oualid F, Freund SM, Ovaa H, Komander D.154(1):169-84Cell10.1016/j.cell.2013.05.04603.07.2013
23505445Profile of the GSK published kinase inhibitor set across ATP-dependent and –independent luciferases: implications for reporter-gene assaysDranchak, P.; MacArthur, R.; Guha, R.; Zuercher, W.J.; Drewry, D.H.; Auld, D.S.; Inglese, J. 8(3):e57888PLoS One10.1371/journal.pone.00578882013
23793157Squeezing the most from every crystal: the fine details of data collection.Krojer, T; Pike, ACW; von Delft, F; 69:1303-1313Acta Crystallographica Section D: Biological Crystallography10.1107/S090744491301328001.7.2013
23872705BET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemiaDa Costa, D; Agathanggelou, A; Perry, T; Weston, V; Petermann, E; Zlatanou, A; Oldreive, C; Wei, W; Stewart, G; Longman, J; Smith, E; Kearns, P; Knapp, S; Stankovic, T; 3:-Blood Cancer Journal10.1038/bcj.2013.241.7.2013
23604472Regulation of pro-angiogenic tissue factor expression in hypoxia-induced human lung cancer cells.Eisenreich, A; Zakrzewicz, A; Huber, K; Thierbach, H; Pepke, W; Goldin-Lang, P; Schultheiss, H-P; Pries, A; Rauch, U; 30:462-470Oncology Reports10.3892/or.2013.241301.7.2013
23814490Functional role and therapeutic potential of the pim-1 kinase in colon carcinoma.Weirauch, U; Beckmann, N; Thomas, M; Grünweller, A; Huber, K; Bracher, F; Hartmann, RK; Aigner, A; 15:783-794Neoplasia10.1593/neo.1317201.7.2013
23816837Substrate Specificity and Oligomerization of Human GMP Synthetase.Welin M, Lehtiö L, Johansson A, Flodin S, Nyman T, Trésaugues L, Hammarström M, Gräslund S, Nordlund PJ. Mol. Biol.10.1016/j.jmb.2013.06.03228.06.2013
23806657Molecular architecture of the ankyrin SOCS box family of Cul5-dependent E3 ubiquitin ligases.Muniz, JRC; Guo, K; Kershaw, NJ; Ayinampudi, V; von Delft, F; Babon, JJ; Bullock, AN; 425:3166-3177Journal of Molecular Biology10.1016/j.jmb.2013.06.0159.9.2013
23791943Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations.Froese, DS; Forouhar, F; Tran, TH; Vollmar, M; Kim, YS; Lew, S; Neely, H; Seetharaman, J; Shen, Y; Xiao, R; Acton, TB; Everett, JK; Cannone, G; Puranik, S; Savitsky, P; Krojer, T; Pilka, ES; Kiyani, W; Lee, WH; Marsden, BD; von Delft, F; Allerston, CK; Spagnolo, L; Gileadi, O; Montelione, GT; Oppermann, U; Yue, WW; Tong, L; 21:1182-1192Structure10.1016/j.str.2013.05.0012.7.2013
23752590Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation.Rothbart SB, Dickson BM, Ong MS, Krajewski K, Houliston S, Kireev DB, Arrowsmith CH, Strahl BD.27(11):1288-98Genes Dev.10.1101/gad.220467.11306.2013
23716676Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.Shintre CA, Pike AC, Li Q, Kim JI, Barr AJ, Goubin S, Shrestha L, Yang J, Berridge G, Ross J, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, Marsden BD, von Delft F, Bullock AN, Gileadi O, Burgess-Brown NA, Carpenter EP110(24):9710-5Proc. Natl. Acad. Sci. U.S.A.10.1073/pnas.121704211011.06.2013
23755147Effect of Single Amino Acid Substitution Observed in Cancer on Pim-1 Kinase Thermodynamic Stability and StructureLori, C; Lantella, A; Pasquo, A; Alexander, LT; Knapp, S; Chiaraluce, R; Consalvi, V; 8:-PLoS ONE10.1371/journal.pone.00648245.6.2013
23616352Selective Bisubstrate Inhibitors with Sub-nanomolar Affinity for Protein Kinase Pim-1Ekambaram, R; Enkvist, E; Vaasa, A; Kasari, M; Raidaru, G; Knapp, S; Uri, A; 8:909-913ChemMedChem10.1002/cmdc.2013000421.6.2013
23572558Constitutively active ALK2 receptor mutants require type II receptor cooperation.Bagarova, J; Vonner, AJ; Armstrong, KA; Börgermann, J; Lai, CSC; Deng, DY; Beppu, H; Alfano, I; Filippakopoulos, P; Morrell, NW; Bullock, AN; Knaus, P; Mishina, Y; Yu, PB; 33:2413-2424Molecular and Cellular Biology10.1128/MCB.01595-1201.6.2013
23725560Quantitative analysis of histone demethylase probes using fluorescence polarization.Xu, W; Podoll, JD; Dong, X; Tumber, A; Oppermann, U; Wang, X; 56:5198-5202Journal of Medicinal Chemistry10.1021/jm301862827.6.2013
23716552Homozygous mutations in a predicted endonuclease are a novel cause of congenital dyserythropoietic anemia type I.Babbs, C; Roberts, NA; Sanchez-Pulido, L; McGowan, SJ; Ahmed, MR; Brown, JM; Sabry, MA; WGS500 Consortium, ; Bentley, DR; McVean, GA; Donnelly, P; Gileadi, O; Ponting, CP; Higgs, DR; Buckle, VJ; 98:1383-1387Haematologica10.3324/haematol.2013.08949001.9.2013
23656407X-ray crystal structure of ERK5 (MAPK7) in complex with a specific inhibitor.Elkins, JM; Wang, J; Deng, X; Pattison, MJ; Arthur, JSC; Erazo, T; Gomez, N; Lizcano, JM; Gray, NS; Knapp, S; 56:4413-4421Journal of Medicinal Chemistry10.1021/jm400083713.6.2013
23623661Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP.Lu, M; Breyssens, H; Salter, V; Zhong, S; Hu, Y; Baer, C; Ratnayaka, I; Sullivan, A; Brown, NR; Endicott, J; Knapp, S; Kessler, BM; Middleton, MR; Siebold, C; Jones, EY; Sviderskaya, EV; Cebon, J; John, T; Caballero, OL; Goding, CR; Lu, X; 23:618-633Cancer Cell10.1016/j.ccr.2013.03.01313.5.2013
23665168Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition.Soundararajan, M; Roos, AK; Savitsky, P; Filippakopoulos, P; Kettenbach, AN; Olsen, JV; Gerber, SA; Eswaran, J; Knapp, S; Elkins, JM; 21:986-996Structure10.1016/j.str.2013.03.0124.6.2013
23434839An essential role for the ATG8 ortholog LC3C in antibacterial autophagy.von Muhlinen N, Akutsu M, Ravenhill BJ, Foeglein Á, Bloor S, Rutherford TJ, Freund SM, Komander D, Randow F.9(5):784-6Autophagy10.4161/auto.2369801.05.2013
23646137A new class of small molecule inhibitor of BMP signaling.Sanvitale, CE; Kerr, G; Chaikuad, A; Ramel, M-C; Mohedas, AH; Reichert, S; Wang, Y; Triffitt, JT; Cuny, GD; Yu, PB; Hill, CS; Bullock, AN; 8:e62721-PLoS ONE10.1371/journal.pone.006272101.01.2013
23614352An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1.Konze KD, Ma A, Li F, Barsyte-Lovejoy D, Parton T, Macnevin CJ, Liu F, Gao C, Huang XP, Kuznetsova E, Rougie M, Jiang A, Pattenden SG, Norris JL, James LI, Roth BL, Brown PJ, Frye SV, Arrowsmith CH, Hahn KM, Wang GG, Vedadi M, Jin JACS Chem. Biol.10.1021/cb400133j24.04.2013
23576556PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains.Picaud, S; Da Costa, D; Thanasopoulou, A; Filippakopoulos, P; Fish, PV; Philpott, M; Fedorov, O; Brennan, P; Bunnage, ME; Owen, DR; Bradner, JE; Taniere, P; O'Sullivan, B; Müller, S; Schwaller, J; Stankovic, T; Knapp, S; 73:3336-3346Cancer Research10.1158/0008-5472.CAN-12-329201.6.2013
23559304Dentine matrix protein 1 (DMP-1) is a marker of bone-forming tumours.Kashima, TG; Dongre, A; Oppermann, U; Athanasou, NA; 462:583-591Virchows Archiv10.1007/s00428-013-1399-z01.5.2013
23566317Why is epigenetics important in understanding the pathogenesis of inflammatory musculoskeletal diseases?Oppermann, U;15:209-Arthritis Research10.1186/ar41863.4.2013
23547776Development of an ALK2-biased BMP type I receptor kinase inhibitor.Mohedas, AH; Xing, X; Armstrong, KA; Bullock, AN; Cuny, GD; Yu, PB; 8:1291-1302ACS Chemical Biology10.1021/cb300655w01.01.2013
23433670Bromo-deaza-SAH: A potent and selective DOT1L inhibitor.Yu W, Smil D, Li F, Tempel W, Fedorov O, Nguyen KT, Bolshan Y, Al-Awar R, Knapp S, Arrowsmith CH, Vedadi M, Brown PJ, Schapira M21(7):1787-94Bioorg. Med. Chem.10.1016/j.bmc.2013.01.04901.04.2013
EPIGENETIC MODIFYING COMPOUNDS AFFECT THE ACTIVITY OF PRIMARY HUMAN ARTICULAR CHONDROCYTES AND MESENCHYMAL STEM CELLS UNDERGOING CHONDROGENESISSnelling, S; Kramm, A; Cain, P; Yapp, C; Carr, A; Price, A; Oppermann, U; 21:S131-S131Osteoarthritis and Cartilage10.1016/j.joca.2013.02.27701.4.2013
Inhibition of BET Bromodomain Targets Genetically Diverse GlioblastomaCheng, Z; Gong, Y; Ma, Y; Lu, K; Lu, X; Pierce, LA; Thompson, RC; Muller, S; Knapp, S; Wang, J; 19:1748-1759Clinical Cancer Research10.1158/1078-0432.CCR-12-30661.4.2013
23549483Construction of human activity-based phosphorylation networksNewman, RH; Hu, J; Rho, HS; Xie, Z; Woodard, C; Neiswinger, J; Cooper, C; Shirley, M; Clark, HM; Hu, S; Hwang, W; Seop Jeong, J; Wu, G; Lin, J; Gao, X; Ni, Q; Goel, R; Xia, S; Ji, H; Dalby, KN; Birnbaum, MJ; Cole, PA; Knapp, S; Ryazanov, AG; Zack, DJ; Blackshaw, S; Pawson, T; Gingras, AC; Desiderio, S; Pandey, A; Turk, BE; Zhang, J; Zhu, H; Qian, J; 9:-Molecular Systems Biology10.1038/msb.2013.121.1.2013
23553820Crystal structures of Klebsiella pneumoniae pantothenate kinase in complex with N-substituted pantothenamides.Li B, Tempel W, Smil D, Bolshan Y, Schapira M, Park HWProteins10.1002/prot.2429030.03.2013
The structural basis of ZMPSTE24-dependent laminopathiesQuigley, A; Dong, YY; Pike, ACW; Dong, L; Shrestha, L; Berridge, G; Stansfeld, PJ; Sansom, MSP; Edwards, AM; Bountra, C; Von Delft, F; Bullock, AN; Burgess-Brown, NA; Carpenter, EP; 340:1604-1607Science10.1126/science.123151329.3.2013
23539603The structural basis of ZMPSTE24-dependent laminopathies.Quigley A, Dong YY, Pike AC, Dong L, Shrestha L, Berridge G, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, von Delft F, Bullock AN, Burgess-Brown NA, Carpenter EP339(6127):1604-7Science10.1126/science.123151329.03.2013
23569359New developments in the management of psoriasis and psoriatic arthritis: a focus on apremilast.Palfreeman, AC; McNamee, KE; McCann, FE; 7:201-210Drug Design, Development and Therapy10.2147/DDDT.S3271301.01.2013
23517011Optimization of 3,5-dimethylisoxazole derivatives as potent BET bromodomain ligands.Hewings DS, Fedorov O, Filippakopoulos P, Martin S, Picaud S, Tumber A, Wells C, Olcina MM, Freeman K, Gill A, Ritchie AJ, Sheppard DW, Russell AJ, Hammond EM, Knapp S, Brennan PE, Conway SJJ. Med. Chem.10.1021/jm301588r21.03.2013
23517011Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands.Hewings, DS; Fedorov, O; Filippakopoulos, P; Martin, S; Picaud, S; Tumber, A; Wells, C; Olcina, MM; Freeman, K; Gill, A; Ritchie, AJ; Sheppard, DW; Russell, AJ; Hammond, EM; Knapp, S; Brennan, PE; Conway, SJ; 56:3217-3227Journal of Medicinal Chemistry10.1021/jm301588r5.4.2013
24900672Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction.Bolshan Y, Getlik M, Kuznetsova E, Wasney GA, Hajian T, Poda G, Nguyen KT, Wu H, Dombrovski L, Dong A, Senisterra G, Schapira M, Arrowsmith CH, Brown PJ, Al-Awar R, Vedadi M, Smil D4(3):353-7ACS Med Chem Lett10.1021/ml300467n14.03.2013
23500148Systems approaches to genomic and epigenetic inter-regulation of peptide hormones in stress and reproduction.Lovejoy DA, Barsyte-Lovejoy DProg. Biophys. Mol. Biol.10.1016/j.pbiomolbio.2013.02.00214.03.2013
23445220Exploiting an Allosteric Binding Site of PRMT3 Yields Potent and Selective Inhibitors.Liu F, Li F, Ma A, Dobrovetsky E, Dong A, Gao C, Korboukh I, Liu J, Smil D, Brown PJ, Frye SV, Arrowsmith CH, Schapira M, Vedadi M, Jin J56(5):2110-24J. Med. Chem.10.1021/jm301833214.03.2013
23505436Crystal Structures of the Catalytic Domain of Human Soluble Guanylate CyclaseAllerston, CK; von Delft, F; Gileadi, O; 8:-PLoS ONE10.1371/journal.pone.00576447.3.2013
The Global Cancer Genomics Consortium's Second Annual Symposium: Genomics Medicine in Cancer ResearchKumar, R; Horvath, A; Mazumder, R; Toi, M; Sato, F; Pillai, MR; Costa, L; Carmo-Fonseca, M; Knapp, S; Dutt, A; Gupta, S; Badwe, R; 4:196-200Genes and Cancer10.1177/19476019134845821.3.2013
23410263Strategy to Target the Substrate Binding site of SET Domain Protein Methyltransferases.Nguyen KT, Li F, Poda G, Smil D, Vedadi M, Schapira MJ Chem Inf Model10.1021/ci300596x01.03.2013
23425511Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits.Shafqat, N; Muniz, JRC; Pilka, ES; Papagrigoriou, E; von Delft, F; Oppermann, U; Yue, WW; 452:27-36Biochemical Journal10.1042/BJ2012158015.5.2013
23420214A structural mapping of mutations causing succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency.Shafqat, N; Kavanagh, KL; Sass, JO; Christensen, E; Fukao, T; Lee, WH; Oppermann, U; Yue, WW; 36:983-987Journal of Inherited Metabolic Disease10.1007/s10545-013-9589-z01.11.2013
23457626Combined inhibition of ErbB1/2 and Notch receptors effectively targets breast ductal carcinoma in situ (DCIS) stem/progenitor cell activity regardless of ErbB2 status.Farnie, G; Willan, PM; Clarke, RB; Bundred, NJ; 8:e56840-PLoS ONE10.1371/journal.pone.005684001.1.2013
23149820Targeting CXCR1/2 significantly reduces breast cancer stem cell activity and increases the efficacy of inhibiting HER2 via HER2-dependent and -independent mechanisms.Singh, JK; Farnie, G; Bundred, NJ; Simões, BM; Shergill, A; Landberg, G; Howell, SJ; Clarke, RB; 19:643-656Clinical Cancer Research10.1158/1078-0432.CCR-12-106301.2.2013
23349464Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.Canning, P; Cooper, CDO; Krojer, T; Murray, JW; Pike, ACW; Chaikuad, A; Keates, T; Thangaratnarajah, C; Hojzan, V; Ayinampudi, V; Marsden, BD; Gileadi, O; Knapp, S; von Delft, F; Bullock, AN; 288:7803-7814Journal of Biological Chemistry10.1074/jbc.M112.43799615.3.2013
23352139A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.Nguyen, GH; Dexheimer, TS; Rosenthal, AS; Chu, WK; Singh, DK; Mosedale, G; Bachrati, CZ; Schultz, L; Sakurai, M; Savitsky, P; Abu, M; McHugh, PJ; Bohr, VA; Harris, CC; Jadhav, A; Gileadi, O; Maloney, DJ; Simeonov, A; Hickson, ID; 20:55-62Cell Chemistry Biology10.1016/j.chembiol.2012.10.01624.1.2013
23288897Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1.Echalier, A; Pan, Y; Birol, M; Tavernier, N; Pintard, L; Hoh, F; Ebel, C; Galophe, N; Claret, FX; Dumas, C; 110:1273-1278Proceedings of the National Academy of Sciences10.1073/pnas.12093451103.1.2013
23326635Solution structure of the Big domain from Streptococcus pneumoniae reveals a novel Ca2+-binding module.Wang T, Zhang J, Zhang X, Xu C, Tu X3:1079Sci Rep10.1038/srep0107916.01.2013
23336033Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases.Myrianthopoulos, V; Kritsanida, M; Gaboriaud-Kolar, N; Magiatis, P; Ferandin, Y; Durieu, E; Lozach, O; Cappel, D; Soundararajan, M; Filippakopoulos, P; Sherman, W; Knapp, S; Meijer, L; Mikros, E; Skaltsounis, A-L; 4:22-26ACS Medicinal Chemistry Letters10.1021/ml300207a10.1.2013
23313374LRIG2 mutations cause urofacial syndrome.Stuart, HM; Roberts, NA; Burgu, B; Daly, SB; Urquhart, JE; Bhaskar, S; Dickerson, JE; Mermerkaya, M; Silay, MS; Lewis, MA; Olondriz, MBO; Gener, B; Beetz, C; Varga, RE; Gülpınar, O; Süer, E; Soygür, T; Ozçakar, ZB; Yalçınkaya, F; Kavaz, A; Bulum, B; Gücük, A; Yue, WW; Erdogan, F; Berry, A; Hanley, NA; McKenzie, EA; Hilton, EN; Woolf, AS; Newman, WG; 92:259-264American Journal of Human Genetics10.1016/j.ajhg.2012.12.0027.2.2013
23292653Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain.James LI, Barsyte-Lovejoy D, Zhong N, Krichevsky L, Korboukh VK, Herold JM, Macnevin CJ, Norris JL, Sagum CA, Tempel W, Marcon E, Guo H, Gao C, Huang XP, Duan S, Emili A, Greenblatt JF, Kireev DB, Jin J, Janzen WP, Brown PJ, Bedford MT, Arrowsmith CH, Frye SVNat. Chem. Biol.10.1038/nchembio.115706.01.2013
23287719A Strategy for Modulation of Enzymes in the Ubiquitin System.Ernst A, Avvakumov G, Tong J, Fan Y, Zhao Y, Alberts P, Persaud A, Walker JR, Neculai AM, Neculai D, Vorobyov A, Garg P, Beatty L, Chan PK, Juang YC, Landry MC, Yeh C, Zeqiraj E, Karamboulas K, Allali-Hassani A, Vedadi M, Tyers M, Moffat J, Sicheri F, Pelletier L, Durocher D, Raught B, Rotin D, Yang J, Moran MF, Dhe-Paganon S, Sidhu SSScience10.1126/science.123016103.01.2013
26682033The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains.Hay, D; Fedorov, O; Filippakopoulos, P; Martin, S; Philpott, M; Picaud, S; Hewings, DS; Uttakar, S; Heightman, TD; Conway, SJ; Knapp, S; Brennan, PE; 4:140-144MedChemComm10.1039/C2MD20189E01.1.2013
24048253MBNL1 and RBFOX2 cooperate to establish a splicing programme involved in pluripotent stem cell differentiationVenables, JP, Lapasset, L, Gadea, G, Fort, P, Klinck, R, Irimia, M, Vignal, E, Thibault, P, Prinos, P, Chabot, B, Abou Elela, S, Roux, P, Lemaitre, J-M, Tazi, J.4:2480Nat Commun10.1038/ncomms34802013
23234552Plasmodium kinases as targets for new-generation antimalarialsLucet, I.S.; Tobin, A.; Drewry, D.; Wilks, A.F.; Doerig, C.2295-310Future Med. Chem.10.4155/fmc.12.1832013
24222354Cancer-Associated Perturbations in Alternative Pre-messenger RNA SplicingShkreta L, Bell B, Revil T, Venables JP, Prinos P, Elela SA, Chabot B. 158:41-94Cancer Treat Res10.1007/978-3-642-31659-3_32013
RBFOX2 enforces the mesenchymal splicing signature in normal and cancer tissuesVenables, J, Brosseau, J-P, Gadea, G, Klinck, R, Prinos, P, Beaulieu, JF, Thibault, P, Tremblay, K, Rousset, F, Tazi, J, Abou Elela, S and Chabot, B. 33(2):396-405Mol Cell Biol2013
25278768Stimulation of Hepatic Apolipoprotein A-I Production by Novel Thieno-Triazolodiazepines: Roles of the Classical Benzodiazepine Receptor, PAF Receptor, and Bromodomain Binding.Kempen, HJ; Bellus, D; Fedorov, O; Nicklisch, S; Filippakopoulos, P; Picaud, S; Knapp, S; 6:47-54Lipid Insights10.4137/Lpi.s1325801.1.2013
22989411Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.Senisterra G, Wu H, Allali-Hassani A, Wasney GA, Barsyte-Lovejoy D, Dombrovski L, Dong A, Nguyen KT, Smil D, Bolshan Y, Hajian T, He H, Seitova A, Chau I, Li F, Poda G, Couture JF, Brown PJ, Al-Awar R, Schapira M, Arrowsmith CH, Vedadi M449(1):151-9Biochem. J.10.1042/BJ2012128001.01.2013
23296203Structural insights into the activation of MST3 by MO25Mehellou, Y; Alessi, DR; Macartney, TJ; Szklarz, M; Knapp, S; Elkins, JM; :-Biochemical and Biophysical Research Communications01.01.2013
23255326Angiotensin II type 2 receptor (AT2 R) localization and antagonist-mediated inhibition of capsaicin responses and neurite outgrowth in human and rat sensory neurons.Anand, U; Facer, P; Yiangou, Y; Sinisi, M; Fox, M; McCarthy, T; Bountra, C; Korchev, YE; Anand, P; 17:1012-1026European Journal of Pain10.1002/j.1532-2149.2012.00269.x01.8.2013
23178455Structural plasticity of histones H3-H4 facilitates their allosteric exchange between RbAp48 and ASF1.Zhang, W; Tyl, M; Ward, R; Sobott, F; Maman, J; Murthy, AS; Watson, AA; Fedorov, O; Bowman, A; Owen-Hughes, T; El Mkami, H; Murzina, NV; Norman, DG; Laue, ED; 20:29-35Nature Structural and Molecular Biology10.1038/nsmb.244601.1.2013
23277358(R)-β-lysine modified elongation factor P functions in translation elongation.Bullwinkle TJ, Zou SB, Rajkovic A, Hersch SJ, Elgamal S, Robinson N, Smil D, Bolshan Y, Navarre WW, Ibba MJ. Biol. Chem.10.1074/jbc.M112.43887931.12.2012
23285239Crystal Structure of the Human SUV39H1 Chromodomain and Its Recognition of Histone H3K9me2/3.Wang T, Xu C, Liu Y, Fan K, Li Z, Sun X, Ouyang H, Zhang X, Zhang J, Li Y, Mackenzie F, Min J, Tu X7(12):e52977PLoS ONE10.1371/journal.pone.005297728.12.2012
23272941Nahuoic Acid A Produced by a Streptomyces sp. Isolated From a Marine Sediment Is a Selective SAM-Competitive Inhibitor of the Histone Methyltransferase SETD8.Williams DE, Dalisay DS, Li F, Amphlett J, Maneerat W, Chavez MA, Wang YA, Matainaho T, Yu W, Brown PJ, Arrowsmith CH, Vedadi M, Andersen RJOrg. Lett.10.1021/ol303416k28.12.2012
23250418Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.Yu W, Chory EJ, Wernimont AK, Tempel W, Scopton A, Federation A, Marineau JJ, Qi J, Barsyte-Lovejoy D, Yi J, Marcellus R, Iacob RE, Engen JR, Griffin C, Aman A, Wienholds E, Li F, Pineda J, Estiu G, Shatseva T, Hajian T, Al-Awar R, Dick JE, Vedadi M, Brown PJ, Arrowsmith CH, Bradner JE, Schapira M3:1288Nat Commun10.1038/ncomms230418.12.2012
23238671A public-private partnership to unlock the untargeted kinome.Knapp S, Arruda P, Blagg J, Burley S, Drewry DH, Edwards A, Fabbro D, Gillespie P, Gray NS, Kuster B, Lackey KE, Mazzafera P, Tomkinson NC, Willson TM, Workman P, Zuercher WJ9(1):3-6Nat. Chem. Biol.10.1038/nchembio.111315.12.2012
23228662Tudor domains of the PRC2 components PHF1 and PHF19 selectively bind to histone H3K36me3.Qin S, Guo Y, Xu C, Bian C, Fu M, Gong S, Min JBiochem. Biophys. Res. Commun.10.1016/j.bbrc.2012.11.11607.12.2012
23217707Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development.Xu Y, Xu C, Kato A, Tempel W, Abreu JG, Bian C, Hu Y, Hu D, Zhao B, Cerovina T, Diao J, Wu F, He HH, Cui Q, Clark E, Ma C, Barbara A, Veenstra GJ, Xu G, Kaiser UB, Liu XS, Sugrue SP, He X, Min J, Kato Y, Shi YG151(6):1200-13Cell10.1016/j.cell.2012.11.01407.12.2012
23219464CDR-H3 Diversity Is Not Required for Antigen Recognition by Synthetic Antibodies.Persson H, Ye W, Wernimont A, Adams JJ, Koide A, Koide S, Lam R, Sidhu SSJ. Mol. Biol.10.1016/j.jmb.2012.11.03703.12.2012
Erratum: Click JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitors (MedChemComm (2012) 3 DOI: 10.1039/C1MD00203A)Spencer, J; Amin, J; Boddiboyena, R; Packham, G; Cavell, BE; Syed Alwi, SS; Paranal, RM; Heightman, TD; Wang, M; Marsden, B; Coxhead, P; Guille, M; Tizzard, GJ; Coles, SJ; Bradner, JE; 3:1562-MedChemComm10.1039/c2md90049a1.12.2012
23086925Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cellsZhang, W; Prakash, C; Sum, C; Gong, Y; Li, Y; Kwok, JJT; Thiessen, N; Pettersson, S; Jones, SJM; Knapp, S; Yang, H; Chin, KC; 287:43137-43155Journal of Biological Chemistry10.1074/jbc.M112.41304714.12.2012
22992735Certhrax Toxin, an Anthrax-related ADP-ribosyltransferase from Bacillus cereus.Visschedyk D, Rochon A, Tempel W, Dimov S, Park HW, Merrill AR287(49):41089-102J. Biol. Chem.10.1074/jbc.M112.41280930.11.2012
23201574Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1.Achour M, Mousli M, Alhosin M, Ibrahim A, Peluso J, Muller CD, Schini-Kerth VB, Hamiche A, Dhe-Paganon S, Bronner CBiochem. Biophys. Res. Commun.10.1016/j.bbrc.2012.11.08728.11.2012
23192353Structural insights into the inactive subunit of the apicoplast-localized caseinolytic protease complex of Plasmodium falciparum.El Bakkouri M, Rathore S, Calmettes C, Wernimont AK, Liu K, Sinha D, Asad M, Jung P, Hui R, Mohmmed A, Houry WAJ. Biol. Chem.10.1074/jbc.M112.41656028.11.2012
Alternative splicing as a generator of functional diversity in cancerPrinos, P, Klinck, R, Pereault, JP, Elela, SA, Chabot, B. Vol. 1, 4, Med Sci11.15.2012
23022382LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy.von Muhlinen N, Akutsu M, Ravenhill BJ, Foeglein Á, Bloor S, Rutherford TJ, Freund SM, Komander D, Randow F.48(3):329-42Mol Cell10.1016/j.molcel.2012.08.02409.11.2012
22954662Histone recognition by human malignant brain tumor domains.Nady N, Krichevsky L, Zhong N, Duan S, Tempel W, Amaya MF, Ravichandran M, Arrowsmith CH423(5):702-18J. Mol. Biol.10.1016/j.jmb.2012.08.02209.11.2012
Mutations in multidomain protein MEGF8 identify a carpenter syndrome subtype associated with defective lateralizationTwigg, SRF; Lloyd, D; Jenkins, D; Elçioglu, NE; Cooper, CDO; Al-Sannaa, N; Annagür, A; Gillessen-Kaesbach, G; Hüning, I; Knight, SJL; Goodship, JA; Keavney, BD; Beales, PL; Gileadi, O; McGowan, SJ; Wilkie, AOM; 91:897-905American Journal of Human Genetics10.1016/j.ajhg.2012.08.0272.11.2012
A Small Molecule Inhibitor of the BLM Helicase That Modulates Chromosome Stability in Human CellsDexheimer, TS; Nguyen, GH; Rosenthal, AS; Bohr, VA; Harris, CC; Jadhav, A; Gileadi, O; Maloney, DJ; Simeonov, A; Hickson, ID; 48:85-85European Journal of Cancer10.1016/S0959-8049(12)72074-901.11.2012
23043551Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2.Zheng W, Ibáñez G, Wu H, Blum G, Zeng H, Dong A, Li F, Hajian T, Allali-Hassani A, Amaya MF, Siarheyeva A, Yu W, Brown PJ, Schapira M, Vedadi M, Min J, Luo M134(43):18004-14J. Am. Chem. Soc.10.1021/ja307060p31.10.2012
23095041Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit.Fish, PV; Filippakopoulos, P; Bish, G; Brennan, PE; Bunnage, ME; Cook, AS; Federov, O; Gerstenberger, BS; Jones, H; Knapp, S; Marsden, B; Nocka, K; Owen, DR; Philpott, M; Picaud, S; Primiano, MJ; Ralph, MJ; Sciammetta, N; Trzupek, JD; 55:9831-9837Journal of Medicinal Chemistry10.1021/jm30105158.11.2012
23093316Epigenetic chemical probes.Müller, S; Brown, PJ; 92:689-693Clinical Pharmacology and Therapeutics10.1038/clpt.2012.15401.12.2012
23071153A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora BDe Antoni, A; Maffini, S; Knapp, S; Musacchio, A; Santaguida, S; 199:269-284Journal of Cell Biology10.1083/jcb.20120511915.10.2012
23063620Mutations in multidomain protein MEGF8 identify a Carpenter syndrome subtype associated with defective lateralization.Twigg, SRF; Lloyd, D; Jenkins, D; Elçioglu, NE; Cooper, CDO; Al-Sannaa, N; Annagür, A; Gillessen-Kaesbach, G; Hüning, I; Knight, SJL; Goodship, JA; Keavney, BD; Beales, PL; Gileadi, O; McGowan, SJ; Wilkie, AOM; 91:897-905American Journal of Human Genetics10.1016/j.ajhg.2012.08.0272.11.2012
23042581Crystal structure of human multiple copies in T-cell lymphoma-1 oncoprotein.Tempel W, Dimov S, Tong Y, Park HW, Hong BSProteins10.1002/prot.2419808.10.2012
23035246Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis.Lu, D; Silhan, J; MacDonald, JT; Carpenter, EP; Jensen, K; Tang, CM; Baldwin, GS; Freemont, PS; 109:16852-16857Proceedings of the National Academy of Sciences10.1073/pnas.120656310916.10.2012
22935698Combined inhibition of Wee1 and Hsp90 activates intrinsic apoptosis in cancer cellsIwai, A.; Bourboulia, D.; Mollapour, M.; Jensen-Taubman, S.; Lee, S.; Donnelly, A. C.; Yoshida, S.; Miyajima, N.; Tsutsumi, S.; Smith, A. K.; Sun, D.; Wu, X.; Blagg, B. S.; Trepel, J. B.; Stetler-Stevenson, W. G.; Neckers, L. 3649-55Cell Cycle10.01.2012
23403638INHIBITION OF BET BROMODOMAIN TARGETS GENETICALLY DIVERSE GLIOBLASTOMACheng, Z; Gong, Y; Ma, Y; Ller-Knapp, SM; Knapp, S; Wang, J; 14:28-28Clinical Cancer Research01.10.2012
22954068A model for abnormal activity recognition and alert generation system for elderly care by hidden conditional random fields using R-transform and generalized discriminant analysis features.Khan, ZA; Sohn, W; 18:641-647Telemedicine and e-Health10.1089/tmj.2011.026801.10.2012
23022729Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation.Rothbart SB, Krajewski K, Nady N, Tempel W, Xue S, Badeaux AI, Barsyte-Lovejoy D, Martinez JY, Bedford MT, Fuchs SM, Arrowsmith CH, Strahl BD19(11):1155-60Nat. Struct. Mol. Biol.10.1038/nsmb.239130.09.2012
23026563C-terminal processing of the teneurin proteins: Independent actions of a teneurin C-terminal associated peptide in hippocampal cells.Chand D, Casatti CA, de Lannoy L, Song L, Kollara A, Barsyte-Lovejoy D, Brown TJ, Lovejoy DA52:38-50Mol. Cell. Neurosci.10.1016/j.mcn.2012.09.00628.09.2012
22924434Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions.Hewings, DS; Rooney, TPC; Jennings, LE; Hay, DA; Schofield, CJ; Brennan, PE; Knapp, S; Conway, SJ; 55:9393-9413Journal of Medicinal Chemistry10.1021/jm300915b26.11.2012
22998443Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.Tahtouh, T; Elkins, JM; Filippakopoulos, P; Soundararajan, M; Burgy, G; Durieu, E; Cochet, C; Schmid, RS; Lo, DC; Delhommel, F; Oberholzer, AE; Pearl, LH; Carreaux, F; Bazureau, J-P; Knapp, S; Meijer, L; 55:9312-9330Journal of Medicinal Chemistry10.1021/jm301034u8.11.2012
22920039Crystal structure of human aurora B in complex with INCENP and VX-680.Elkins, JM; Santaguida, S; Musacchio, A; Knapp, S; 55:7841-7848Journal of Medicinal Chemistry10.1021/jm300895413.9.2012
22977237Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva.Chaikuad, A; Alfano, I; Kerr, G; Sanvitale, CE; Boergermann, JH; Triffitt, JT; von Delft, F; Knapp, S; Knaus, P; Bullock, AN; 287:36990-36998Journal of Biological Chemistry10.1074/jbc.M112.36593226.10.2012
22913516Structural determination of the phosphorylation domain of the ryanodine receptor.Sharma P, Ishiyama N, Nair U, Li W, Dong A, Miyake T, Wilson A, Ryan T, MacLennan DH, Kislinger T, Ikura M, Dhe-Paganon S, Gramolini AO279(20):3952-64FEBS J.10.1111/j.1742-4658.2012.08755.x11.09.2012
22698694C-Terminal region of teneurin-1 co-localizes with dystroglycan and modulates cytoskeletal organization through an extracellular signal-regulated kinase-dependent stathmin- and filamin A-mediated mechanism in hippocampal cells.Chand D, Song L, deLannoy L, Barsyte-Lovejoy D, Ackloo S, Boutros PC, Evans K, Belsham DD, Lovejoy DA219:255-70Neuroscience10.1016/j.neuroscience.2012.05.06906.09.2012
ENZYMATIC CHARACTERIZATION AND THERMAL STABILITY ASSAYS ESTABLISH METHYLMALONYL-COA MUTASE MUTATIONS AS A TARGET FOR PHARMACOLOGICAL CHAPERONE SCREENINGForny, P; Froese, DS; Suormala, T; Yue, WW; Baumgartner, MR; 35:S9-S9Journal of Inherited Metabolic Disease01.9.2012
The therapeutic potential of acetyl-lysine and methyl-lysine effector domainsBrennan, P; Filippakopoulos, P; Knapp, S; 9:-Drug Discovery Today: Therapeutic Strategies10.1016/j.ddstr.2012.04.0011.1.2012
22788793Druggability analysis and structural classification of bromodomain acetyl-lysine binding sitesVidler, LR; Brown, N; Knapp, S; Hoelder, S; 55:7346-7359Journal of Medicinal Chemistry10.1021/jm300346w13.9.2012
22952628Structures of human DPP7 reveal the molecular basis of specific inhibition and the architectural diversity of proline-specific peptidases.Bezerra GA, Dobrovetsky E, Dong A, Seitova A, Crombett L, Shewchuk LM, Hassell AM, Sweitzer SM, Sweitzer TD, McDevitt PJ, Johanson KO, Kennedy-Wilson KM, Cossar D, Bochkarev A, Gruber K, Dhe-Paganon S7(8):e43019PLoS ONE10.1371/journal.pone.004301929.08.2012
22922757Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, Malstrom S, Khan TM, Kung C, Skoumbourdis AP, Veith H, Southall N, Walsh MJ, Brimacombe KR, Leister W, Lunt SY, Johnson ZR, Yen KE, Kunii K, Davidson SM, Christofk HR, Austin CP, Inglese J, Harris MH, Asara JM, Stephanopoulos G, Salituro FG, Jin S, Dang L, Auld DS, Park HW, Cantley LC, Thomas CJ, Vander Heiden MG8(10):839-47Nat. Chem. Biol.10.1038/nchembio.106026.08.2012
22921070An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.Echalier, A; Cot, E; Camasses, A; Hodimont, E; Hoh, F; Jay, P; Sheinerman, F; Krasinska, L; Fisher, D; 19:1028-1040Cell Chemistry Biology10.1016/j.chembiol.2012.06.01501.8.2012
22761334Pharmacological inhibition of LIM kinase stabilizes microtubules and inhibits neoplastic growth.Prudent, R; Vassal-Stermann, E; Nguyen, C-H; Pillet, C; Martinez, A; Prunier, C; Barette, C; Soleilhac, E; Filhol, O; Beghin, A; Valdameri, G; Honoré, S; Aci-Sèche, S; Grierson, D; Antonipillai, J; Li, R; Di Pietro, A; Dumontet, C; Braguer, D; Florent, J-C; Knapp, S; Bernard, O; Lafanechère, L; 72:4429-4439Cancer Research10.1158/0008-5472.CAN-11-33421.9.2012
22917970Structural basis for ASPP2 recognition by the tumor suppressor p73.Canning, P; von Delft, F; Bullock, AN; 423:515-527Journal of Molecular Biology10.1016/j.jmb.2012.08.0052.11.2012
Developing small molecule inhibitors of the CREBBP bromodomain-histone interactionRooney, TPC; Fedorov, O; Filippakopoulos, P; Wang, M; Philpott, M; Cook, A; Heightman, TD; Knapp, S; Pryde, D; Brennan, PE; Conway, SJ; 244:-ACS National Meeting Book of Abstracts19.8.2012
22901802Small-molecule inhibition of BRDT for male contraception.Matzuk, MM; McKeown, MR; Filippakopoulos, P; Li, Q; Ma, L; Agno, JE; Lemieux, ME; Picaud, S; Yu, RN; Qi, J; Knapp, S; Bradner, JE; 150:673-684Cell10.1016/j.cell.2012.06.04517.8.2012
22644265The Development of a High-Content Screening Binding Assay for the Smoothened ReceptorBee, W.T.; Xie, W.; Truong, M.; Will, M.; Turunen, B.; Zuercher, W.J.; McMillan, L.; Li, H.; Hornberger, K.R.; Davenport, E.A.; Ames, R.S.; Kallal, L.A. 17(7):900-11J Biomol Screen10.1177/108705711244787208.2012
22718786ChromoHub: a data hub for navigators of chromatin-mediated signalling.Liu L, Zhen XT, Denton E, Marsden BD, Schapira M28(16):2205-6Bioinformatics10.1093/bioinformatics/bts34015.08.2012
The bromodomain interaction moduleFilippakopoulos, P; Knapp, S; 586:2692-2704FEBS Letters10.1016/j.febslet.2012.04.04514.8.2012
22795084An allosteric inhibitor of protein arginine methyltransferase 3.Siarheyeva A, Senisterra G, Allali-Hassani A, Dong A, Dobrovetsky E, Wasney GA, Chau I, Marcellus R, Hajian T, Liu F, Korboukh I, Smil D, Bolshan Y, Min J, Wu H, Zeng H, Loppnau P, Poda G, Griffin C, Aman A, Brown PJ, Jin J, Al-Awar R, Arrowsmith CH, Schapira M, Vedadi M20(8):1425-35Structure10.1016/j.str.2012.06.00108.08.2012
22842901A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.Kruidenier, L; Chung, C-W; Cheng, Z; Liddle, J; Che, K; Joberty, G; Bantscheff, M; Bountra, C; Bridges, A; Diallo, H; Eberhard, D; Hutchinson, S; Jones, E; Katso, R; Leveridge, M; Mander, PK; Mosley, J; Ramirez-Molina, C; Rowland, P; Schofield, CJ; Sheppard, RJ; Smith, JE; Swales, C; Tanner, R; Thomas, P; Tumber, A; Drewes, G; Oppermann, U; Patel, DJ; Lee, K; Wilson, DM; 488:404-408Nature10.1038/nature1126216.8.2012
22628426The Global Cancer Genomics Consortium: Interfacing genomics and cancer medicineEswaran, J; Gupta, S; Dutt, A; Toi, M; Pillai, MR; Costa, L; Knapp, S; Badwe, R; Kumar, R; 72:3720-3724Cancer Research10.1158/0008-5472.CAN-12-10541.8.2012
Leucettines, a family of pharmacological inhibitors of DYRKs & CLKs kinases derived from the marine sponge Leucettamine BTahtouh, T; Fedorov, O; Lozach, O; Carreaux, F; Bazureau, JP; Meunier, J; Maurice, T; Knapp, S; Meijer, L; 78:1072-1072Planta Medica01.8.2012
Versatile selective kinase inhibitors: Chemistry and biology of indirubinsGaboriaud-Kolar, N; Magiatis, P; Brivanlou, A; Greengard, P; Knapp, S; Nam, S; Jove, R; Meijer, L; Mikros, E; Skaltsounis, AL; 78:1080-1080Planta Medica01.8.2012
22730246Development and application of a fluoride-detection-based fluorescence assay for gamma-butyrobetaine hydroxylase.Rydzik AM,Leung IK,Kochan GT,Thalhammer A,Oppermann U,Claridge TD,Schofield CJ. 13(11):1559-1563Chembiochem : a European journal of chemical biologyhttp://dx.doi.org/10.1002/cbic.201200256 23/07/2012
22810237Structure and mechanism of human UDP-xylose synthase: evidence for a promoting role of sugar ring distortion in a three-step catalytic conversion of UDP-glucuronic acid.Eixelsberger, T; Sykora, S; Egger, S; Brunsteiner, M; Kavanagh, KL; Oppermann, U; Brecker, L; Nidetzky, B; 287:31349-31358Journal of Biological Chemistry10.1074/jbc.M112.3867067.9.2012
22676716Phosphoglucomutase is absent in Trypanosoma brucei and redundantly substituted by phosphomannomutase and phospho-N-acetylglucosamine mutase.Bandini G, Mariño K, Güther ML, Wernimont AK, Kuettel S, Qiu W, Afzal S, Kelner A, Hui R, Ferguson MA85(3):513-34Mol. Microbiol.10.1111/j.1365-2958.2012.08124.x12.07.2012
22589545Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation.Campbell SJ, Edwards RA, Leung CC, Neculai D, Hodge CD, Dhe-Paganon S, Glover JN287(28):23900-10J. Biol. Chem.10.1074/jbc.M112.35965306.07.2012
22771810WITHDRAWN: Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1.Achour M, Mousli M, Alhosin M, Ibrahim A, Peluso J, Muller CD, Schini-Kerth VB, Hamiche A, Dhe-Paganon SBiochem. Biophys. Res. Commun.10.1016/j.bbrc.2012.06.13004.07.2012
22493426IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold.Dixon MJ, Gray A, Schenning M, Agacan M, Tempel W, Tong Y, Nedyalkova L, Park HW, Leslie NR, van Aalten DM, Downes CP, Batty IH287(27):22483-96J. Biol. Chem.10.1074/jbc.M112.35277329.06.2012
22724510Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.Rose, NR; Woon, ECY; Tumber, A; Walport, LJ; Chowdhury, R; Li, XS; King, ONF; Lejeune, C; Ng, SS; Krojer, T; Chan, MC; Rydzik, AM; Hopkinson, RJ; Che, KH; Daniel, M; Strain-Damerell, C; Gileadi, C; Kochan, G; Leung, IKH; Dunford, J; Yeoh, KK; Ratcliffe, PJ; Burgess-Brown, N; von Delft, F; Muller, S; Marsden, B; Brennan, PE; McDonough, MA; Oppermann, U; Klose, RJ; Schofield, CJ; Kawamura, A; 55:6639-6643Journal of Medicinal Chemistry10.1021/jm300677j26.7.2012
22730246Development and application of a fluoride-detection-based fluorescence assay for γ-butyrobetaine hydroxylase.Rydzik, AM; Leung, IKH; Kochan, GT; Thalhammer, A; Oppermann, U; Claridge, TDW; Schofield, CJ; 13:1559-1563ChemBioChem10.1002/cbic.20120025623.7.2012
22720794Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family.Chaikuad, A; Pilka, ES; De Riso, A; von Delft, F; Kavanagh, KL; Vénien-Bryan, C; Oppermann, U; Yue, WW; 12:14-BMC Structural Biology10.1186/1472-6807-12-1421.6.2012
22027370Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation.Keates T, Cooper CD, Savitsky P, Allerston CK, Phillips C, Hammarström M, Daga N, Berridge G, Mahajan P, Burgess-Brown NA, Müller S, Gräslund S, Gileadi O29(5):515-25N Biotechnol10.1016/j.nbt.2011.10.00715.06.2012
22692201Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases.Sengerová, B; Allerston, CK; Abu, M; Lee, SY; Hartley, J; Kiakos, K; Schofield, CJ; Hartley, JA; Gileadi, O; McHugh, PJ; 287:26254-26267Journal of Biological Chemistry10.1074/jbc.M112.36724327.7.2012
22615379Structural basis for substrate specificity and catalysis of human histone acetyltransferase 1.Wu H, Moshkina N, Min J, Zeng H, Joshua J, Zhou MM, Plotnikov AN109(23):8925-30Proc. Natl. Acad. Sci. U.S.A.10.1073/pnas.111411710905.06.2012
22665270A detailed mammosphere assay protocol for the quantification of breast stem cell activity.Shaw, FL; Harrison, H; Spence, K; Ablett, MP; Simões, BM; Farnie, G; Clarke, RB; 17:111-117Journal of Mammary Gland Biology and Neoplasia10.1007/s10911-012-9255-35.6.2012
Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritimaLevisson, M; Han, GW; Deller, MC; Xu, Q; Biely, P; Hendriks, S; Ten Eyck, LF; Flensburg, C; Roversi, P; Miller, MD; McMullan, D; von Delft, F; Kreusch, A; Deacon, AM; van der Oost, J; Lesley, SA; Elsliger, MA; Kengen, SWM; Wilson, IA; 80:1545-1559Proteins10.1002/prot.240411.6.2012
22649097Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock.Xu C, Jin J, Bian C, Lam R, Tian R, Weist R, You L, Nie J, Bochkarev A, Tempel W, Tan CS, Wasney GA, Vedadi M, Gish GD, Arrowsmith CH, Pawson T, Yang XJ, Min J5(226):ra39Sci Signal10.1126/scisignal.200297929.05.2012
226428653-methylcrotonyl-CoA carboxylase deficiency: clinical, biochemical, enzymatic and molecular studies in 88 individuals.Grünert, SC; Stucki, M; Morscher, RJ; Suormala, T; Bürer, C; Burda, P; Christensen, E; Ficicioglu, C; Herwig, J; Kölker, S; Möslinger, D; Pasquini, E; Santer, R; Schwab, KO; Wilcken, B; Fowler, B; Yue, WW; Baumgartner, MR; 7:31-Orphanet Journal of Rare Diseases10.1186/1750-1172-7-3129.5.2012
22642810Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function.Froese, DS; Krojer, T; Wu, X; Shrestha, R; Kiyani, W; von Delft, F; Gravel, RA; Oppermann, U; Yue, WW; 51:5083-5090Biochemistry10.1021/bi300150y26.6.2012
22662200Pan-pathway based interaction profiling of FDA-approved nucleoside and nucleobase analogs with enzymes of the human nucleotide metabolism.Egeblad L, Welin M, Flodin S, Gräslund S, Wang L, Balzarini J, Eriksson S, Nordlund P7(5):e37724PLoS ONE10.1371/journal.pone.003772425.05.2012
22589386The structure of the full-length tetrameric PKA regulatory RIIβ complex reveals the mechanism of allosteric PKA activation.Elkins, JM; Knapp, S; 5:pe21-Science Signaling10.1126/scisignal.200305315.5.2012
22575888The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4.Watson, AA; Mahajan, P; Mertens, HDT; Deery, MJ; Zhang, W; Pham, P; Du, X; Bartke, T; Zhang, W; Edlich, C; Berridge, G; Chen, Y; Burgess-Brown, NA; Kouzarides, T; Wiechens, N; Owen-Hughes, T; Svergun, DI; Gileadi, O; Laue, ED; 422:3-17Journal of Molecular Biology10.1016/j.jmb.2012.04.0317.9.2012
22411408Fold of the conserved DTC domain in Deltex proteins.Obiero J, Walker JR, Dhe-Paganon S80(5):1495-9Proteins10.1002/prot.2405401.05.2012
22633412Rapid determination of multiple linear kinase substrate motifs by mass spectrometryKettenbach, AN; Wang, T; Faherty, BK; Madden, DR; Knapp, S; Bailey-Kellogg, C; Gerber, SA; 19:608-618Cell Chemistry Biology10.1016/j.chembiol.2012.04.01125.5.2012
22389315P-cadherin is coexpressed with CD44 and CD49f and mediates stem cell properties in basal-like breast cancer.Vieira, AF; Ricardo, S; Ablett, MP; Dionísio, MR; Mendes, N; Albergaria, A; Farnie, G; Gerhard, R; Cameselle-Teijeiro, JF; Seruca, R; Schmitt, F; Schmitt, F; Clarke, RB; Paredes, J; 30:854-864STEM CELLS10.1002/stem.107501.5.2012
22525752An analysis of subdomain orientation, conformational change and disorder in relation to crystal packing of aspartic proteinases.Bailey, D; Carpenter, EP; Coker, A; Coker, S; Read, J; Jones, AT; Erskine, P; Aguilar, CF; Badasso, M; Toldo, L; Rippmann, F; Sanz-Aparicio, J; Albert, A; Blundell, TL; Roberts, NB; Wood, SP; Cooper, JB; 68:541-552Acta Crystallographica Section D: Biological Crystallography10.1107/S090744491200481701.5.2012
22539638Novel insights into the regulation of malarial calcium-dependent protein kinase 1.Ahmed A, Gaadhe K, Sharma GP, Kumar N, Neculai M, Hui R, Mohanty D, Sharma P26(8):3212-21FASEB J.10.1096/fj.12-20387725.04.2012
22493238Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III.Bezerra GA, Dobrovetsky E, Viertlmayr R, Dong A, Binter A, Abramic M, Macheroux P, Dhe-Paganon S, Gruber K109(17):6525-30Proc. Natl. Acad. Sci. U.S.A.10.1073/pnas.111800510924.04.2012
22520759Small-molecule inhibitors of the c-Fes protein-tyrosine kinase.Hellwig, S; Miduturu, CV; Kanda, S; Zhang, J; Filippakopoulos, P; Salah, E; Deng, X; Choi, HG; Zhou, W; Hur, W; Knapp, S; Gray, NS; Smithgall, TE; 19:529-540Cell Chemistry Biology10.1016/j.chembiol.2012.01.02020.4.2012
22514736Structural basis of the chromodomain of Cbx3 bound to methylated peptides from histone h1 and G9a.Ruan J, Ouyang H, Amaya MF, Ravichandran M, Loppnau P, Min J, Zang J7(4):e35376PLoS ONE10.1371/journal.pone.003537613.04.2012
22498752Epigenetic protein families: a new frontier for drug discovery.Arrowsmith CH, Bountra C, Fish PV, Lee K, Schapira M11(5):384-400Nat Rev Drug Discov10.1038/nrd367413.04.2012
22496338A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.Sheng Y, Hong JH, Doherty R, Srikumar T, Shloush J, Avvakumov GV, Walker JR, Xue S, Neculai D, Wan JW, Kim SK, Arrowsmith CH, Raught B, Dhe-Paganon S11(8):329-41Mol. Cell Proteomics10.1074/mcp.O111.01370610.04.2012
22464331Histone recognition and large-scale structural analysis of the human bromodomain family.Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Müller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S149(1):214-31Cell10.1016/j.cell.2012.02.01330.03.2012
22470497Crystal structures of the tetratricopeptide repeat domains of kinesin light chains: insight into cargo recognition mechanisms.Zhu H, Lee HY, Tong Y, Hong BS, Kim KP, Shen Y, Lim KJ, Mackenzie F, Tempel W, Park HW7(3):e33943PLoS ONE10.1371/journal.pone.003394328.03.2012
3,5-Dimethylisoxazoles inhibit the bromodomain-histone protein-protein interactionHewings, DS; Wang, M; Philpott, M; Fedorov, O; Uttarkar, S; Filippakopoulos, P; Picaud, S; Vuppusetty, C; Marsden, B; Heightman, TD; Knapp, S; Brennan, P; Conway, SJ; 243:-ACS National Meeting Book of Abstracts25.3.2012
Developing chemical probes for the BET bromodomainsHewings, DS; Wang, M; Philpott, M; Fedorov, O; Uttarkar, S; Filippakopoulos, P; Picaud, S; Vuppusetty, C; Marsden, B; Heightman, TD; Knapp, S; Brennan, P; Conway, SJ; 243:-ACS National Meeting Book of Abstracts25.3.2012
22449972Crystal structures of the Tudor domains of human PHF20 reveal novel structural variations on the Royal Family of proteins.Adams-Cioaba MA, Li Z, Tempel W, Guo Y, Bian C, Li Y, Lam R, Min J586(6):859-65FEBS Lett.10.1016/j.febslet.2012.02.01223.03.2012
22429898Crystal structures from the Plasmodium peroxiredoxins: new insights into oligomerization and product binding.Qiu W, Dong A, Pizarro JC, Botchkarsev A, Min J, Wernimont AK, Hills T, Hui R, Artz JD12:2BMC Struct. Biol.10.1186/1472-6807-12-219.03.2012
22203037Proteins Associated with the Exon Junction Complex Also Control the Alternative Splicing of Apoptotic RegulatorsMichelle L, Toutant J, Thibault P, Durand M, Garneau D, Lapointe E, Couture S, Le Hir H, Klinck R, Abou Elela S, Prinos P and Chabot B. 32(5):954-67Mol Cell Biol10.1128/MCB.06130-1103.15.2012
22392982Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity.No JH, de Macedo Dossin F, Zhang Y, Liu YL, Zhu W, Feng X, Yoo JA, Lee E, Wang K, Hui R, Freitas-Junior LH, Oldfield E109(11):4058-63Proc. Natl. Acad. Sci. U.S.A.10.1073/pnas.111821510913.03.2012
22366092Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: implications for biological assembly and inhibitor development.Pilka, ES; Kochan, G; Oppermann, U; Yue, WW; 419:485-489Biochemical and Biophysical Research Communications10.1016/j.bbrc.2012.02.03816.3.2012
22389709Structural stability of human protein tyrosine phosphatase ρ catalytic domain: Effect of point mutationsPasquo, A; Consalvi, V; Knapp, S; Alfano, I; Ardini, M; Stefanini, S; Chiaraluce, R; 7:-PLoS ONE10.1371/journal.pone.003255528.2.2012
22321395Crystal structure of inactive form of Rab3B.Zhang W, Shen Y, Jiao R, Liu Y, Deng L, Qi C418(4):841-4Biochem. Biophys. Res. Commun.10.1016/j.bbrc.2012.01.12424.02.2012
22362889The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure.Adams, CJ; Pike, ACW; Maniam, S; Sharpe, TD; Coutts, AS; Knapp, S; La Thangue, NB; Bullock, AN; 109:3778-3783Proceedings of the National Academy of Sciences10.1073/pnas.11137311096.3.2012
22363433Crystal structure of TDRD3 and methyl-arginine binding characterization of TDRD3, SMN and SPF30.Liu K, Guo Y, Liu H, Bian C, Lam R, Liu Y, Mackenzie F, Rojas LA, Reinberg D, Bedford MT, Xu RM, Min J7(2):e30375PLoS ONE10.1371/journal.pone.003037517.02.2012
22265972Crystal structures of the coil 2B fragment and the globular tail domain of human lamin B1.Ruan J, Xu C, Bian C, Lam R, Wang JP, Kania J, Min J, Zang J586(4):314-8FEBS Lett.10.1016/j.febslet.2012.01.00717.02.2012
22283393Two ZnF-UBP domains in isopeptidase T (USP5).Avvakumov GV, Walker JR, Xue S, Allali-Hassani A, Asinas A, Nair UB, Fang X, Zuo X, Wang YX, Wilkinson KD, Dhe-Paganon S51(6):1188-98Biochemistry10.1021/bi200854q14.02.2012
22178476Structural insights into the allosteric effects of 4EBP1 on the eukaryotic translation initiation factor eIF4E.Siddiqui N, Tempel W, Nedyalkova L, Volpon L, Wernimont AK, Osborne MJ, Park HW, Borden KL415(5):781-92J. Mol. Biol.10.1016/j.jmb.2011.12.00203.02.2012
22298003Crystallization and preliminary X-ray diffraction analysis of human dipeptidyl peptidase 10 (DPPY), a component of voltage-gated potassium channels.Bezerra GA, Dobrovetsky E, Seitova A, Dhe-Paganon S, Gruber K68(Pt 2):214-7Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.10.1107/S174430911105523001.02.2012
22442216On the need for an international effort to capture, share and use crystallization screening dataNewman, J; Bolton, EE; Müller-Dieckmann, J; Fazio, VJ; Gallagher, DT; Lovell, D; Luft, JR; Peat, TS; Ratcliffe, D; Sayle, RA; Snell, EH; Taylor, K; Vallotton, P; Velanker, S; von Delft, F; 68:253-258Acta Crystallographica Section F: Structural Biology and Crystallization Communications10.1107/S174430911200261801.2.2012
22411095Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima.Levisson, M; Han, GW; Deller, MC; Xu, Q; Biely, P; Hendriks, S; Ten Eyck, LF; Flensburg, C; Roversi, P; Miller, MD; McMullan, D; von Delft, F; Kreusch, A; Deacon, AM; van der Oost, J; Lesley, SA; Elsliger, M-A; Kengen, SWM; Wilson, IA; 80:1545-1559Proteins10.1002/prot.2404101.6.2012
22069321Protein aggregates are recruited to aggresome by histone deacetylase 6 via unanchored ubiquitin C termini.Ouyang H, Ali YO, Ravichandran M, Dong A, Qiu W, MacKenzie F, Dhe-Paganon S, Arrowsmith CH, Zhai RG287(4):2317-27J. Biol. Chem.10.1074/jbc.M111.27373020.01.2012
22241642Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases.Woon, ECY; Tumber, A; Kawamura, A; Hillringhaus, L; Ge, W; Rose, NR; Ma, JHY; Chan, MC; Walport, LJ; Che, KH; Ng, SS; Marsden, BD; Oppermann, U; McDonough, MA; Schofield, CJ; 51:1631-1634Angewandte Chemie International Edition10.1002/anie.20110783313.2.2012
22722314PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphomaBrault, L; Menter, T; Obermann, EC; Knapp, S; Thommen, S; Schwaller, J; Tzankov, A; :-British Journal of Cancer01.01.2012
Target/s Identification Approaches – Experimental Biological ApproachesHuber, K; Superti-Furga, G; Winter, GE; :94-11010.1039/9781849734912-0009401.01.2012
The therapeutic potential of acetyl-lysine and methyl-lysine effector domainsBrennan, P; Filippakopoulos, P; Knapp, S; :-Drug Discovery Today: Therapeutic Strategies01.01.2012
Click JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitorsSpencer, J; Amin, J; Boddiboyena, R; Packham, G; Cavell, BE; Syed Alwi, SS; Paranal, RM; Heightman, TD; Wang, M; Marsden, B; Coxhead, P; Guille, M; Tizzard, GJ; Coles, SJ; Bradner., JE; 3:61-64MedChemComm10.1039/c1md00203a1.1.2012
21945179The Cdc48 machine in endoplasmic reticulum associated protein degradation.Wolf DH, Stolz A.1823(1):117-24Biochim Biophys Acta10.1016/j.bbamcr.2011.09.00201.01.2012
22918538Fragment screening of cyclin G-associated kinase by weak affinity chromatographyMeiby, E; Knapp, S; Elkins, JM; Ohlson, S; :1-9Analytical and Bioanalytical Chemistry01.01.2012
22350908Use of CPY and its derivatives to study protein quality control in various cell compartments.Stolz A, Wolf DH.832:489-504Methods Mol Biol10.1007/978-1-61779-474-2_3501.01.2012
21960218Kinase inhibitor selectivity profiling using differential scanning fluorimetry.Fedorov, O; Niesen, FH; Knapp, S; 795:109-118Methods in Molecular Biology10.1007/978-1-61779-337-0_701.1.2012
22147708Structural and functional insights into the DNA replication factor Cdc45 reveal an evolutionary relationship to the DHH family of phosphoesterases.Krastanova, I; Sannino, V; Amenitsch, H; Gileadi, O; Pisani, FM; Onesti, S; 287:4121-4128Journal of Biological Chemistry10.1074/jbc.M111.2853953.2.2012
221364337,8-dichloro-1-oxo-β-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes.Huber, K; Brault, L; Fedorov, O; Gasser, C; Filippakopoulos, P; Bullock, AN; Fabbro, D; Trappe, J; Schwaller, J; Knapp, S; Bracher, F; 55:403-413Journal of Medicinal Chemistry10.1021/jm201286z3.1.2012
22123821Structural and kinetic evidence that catalytic reaction of human UDP-glucose 6-dehydrogenase involves covalent thiohemiacetal and thioester enzyme intermediates.Egger, S; Chaikuad, A; Klimacek, M; Kavanagh, KL; Oppermann, U; Nidetzky, B; 287:2119-2129Journal of Biological Chemistry10.1074/jbc.M111.31301513.1.2012
22137933Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family.Filippakopoulos, P; Picaud, S; Fedorov, O; Keller, M; Wrobel, M; Morgenstern, O; Bracher, F; Knapp, S; 20:1878-1886Bioorganic and Medicinal Chemistry10.1016/j.bmc.2011.10.08001.3.2012
21985771Analysis of conditions affecting auto-phosphorylation of human kinases during expression in bacteria.Shrestha, A; Hamilton, G; O'Neill, E; Knapp, S; Elkins, JM; 81:136-143Protein Expression and Purification10.1016/j.pep.2011.09.01201.1.2012
22146969Druggability of methyl-lysine binding sitesSantiago C,Nguyen K,Schapira M25 (12):1171-8J Comput Aided Mol Des.10.1007/s10822-011-9505-212.25.2011
21924824A novel C-terminal HSP90 inhibitor KU135 induces apoptosis and cell cycle arrest in melanoma cellsamadi, A. K.; Zhang, X.; Mukerji, R.; Donnelly, A. C.; Blagg, B. S.; Cohen, M. S.158-67Cancer Lett10.1016/j.canlet.2011.07.03112.22.2011
22160680Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.Chaikuad, A; Froese, DS; Berridge, G; von Delft, F; Oppermann, U; Yue, WW; 108:21028-21033Proceedings of the National Academy of Sciences10.1073/pnas.111392110827.12.2011
22157957An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains.Licchesi JD, Mieszczanek J, Mevissen TE, Rutherford TJ, Akutsu M, Virdee S, El Oualid F, Chin JW, Ovaa H, Bienz M, Komander D.19(1):62-71Nat Struct Mol Biol10.1038/nsmb.216911.12.2011
22146969Druggability of methyl-lysine binding sites.Santiago C, Nguyen K, Schapira M25(12):1171-8J. Comput. Aided Mol. Des.10.1007/s10822-011-9505-207.12.2011
Visualisation and efficient communication in structure-based lead discoveryMarsden, BD; Abagyan, R; Lee, WH; :176-18910.2174/9781608051427111010101761.12.2011
Directed differentiation of human induced pluripotent stem cells into chondrocytesHala, S; Yapp, C; Kramm, A; Carpenter, L; Watt, S; Carr, A; Dunford, J; Oppermann, U; Tirlapur, U; 92:A21-A22International Journal of Experimental Pathology01.12.2011
21902868The interplay between Leishmania promastigotes and human Natural Killer cells in vitro leads to direct lysis of Leishmania by NK cells and modulation of NK cell activity by Leishmania promastigotesLieke T, Nylen S, Eidsmo L, Schmetz C, Berg L, Akuffo H. 138(14):1898-909Parasitology10.1017/S0031182011001363Dec. 2011
22180821Recombinant protein quality evaluation: proposal for a minimal information standard.Buckle AM, Bate MA, Androulakis S, Cinquanta M, Basquin J, Bonneau F, Chatterjee DK, Cittaro D, Gräslund S, Gruszka A, Page R, Suppmann S, Wheeler JX, Agostini D, Taussig M, Taylor CF, Bottomley SP, Villaverde A, de Marco A5(2):195-7Stand Genomic Sci10.4056/sigs.183451130.11.2011
Inhibition of BRD4 Bromodomains Is a Potent Novel Strategy to Target Apoptosis Resistance in Paediatric ALLDa Costa, D; Weston, VJ; Wei, W; Agathanggelou, A; Petermann, E; Knapp, S; Kearns, PR; Stankovic, T; 118:37-37Blood18.11.2011
22042850Estrogen Related Receptor-α is a Metabolic Regulator of Effector T cell Activation and Differentiation. Michalek, R.D.; Gerriets, V.A.; Nichols, A.; Inoue, M.; Kazmin, D.; Chang, C-Y.; Dwyer, M.; Nelson, E.; Pollizzi, K.; Ilkayeva, O.; Giguere, V.; Zuercher, W.J.; Powell, J.; Shinohare, M.; McDonnell, D.P.; Rathmell, J.C. 108(45):18348-53Proc Natl Acad Sci U S A10.1073/pnas.110885610811.08.2011
22066913Thermal denaturation assays in chemical biology.Senisterra G, Chau I, Vedadi M10(2):128-36Assay Drug Dev Technol10.1089/adt.2011.039008.11.2011
22039910Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cellsEskew, J. D.; Sadikot, T.; Morales, P.; Duren, A.; Dunwiddie, I.; Swink, M.; Zhang, X.; Hembruff, S.; Donnelly, A.; Rajewski, R. A.; Blagg, B. S.; Manjarrez, J. R.; Matts, R. L.; Holzbeierlein, J. M.; Vielhauer, G. A.11:468.BMC Cancer 10.1186/1471-2407-11-46810.30.2011
21971548Mnl2, a novel component of the ER associated protein degradation pathway.Martinez Benitez E, Stolz A, Becher A, Wolf DH.414(3):528-32Biochem Biophys Res Commun10.1016/j.bbrc.2011.09.10028.10.2011
22020785Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction.Kryshtafovych A, Moult J, Bartual SG, Bazan JF, Berman H, Casteel DE, Christodoulou E, Everett JK, Hausmann J, Heidebrecht T, Hills T, Hui R, Hunt JF, Seetharaman J, Joachimiak A, Kennedy MA, Kim C, Lingel A, Michalska K, Montelione GT, Otero JM, Perrakis A, Pizarro JC, van Raaij MJ, Ramelot TA, Rousseau F, Tong L, Wernimont AK, Young J, Schwede T79 Suppl 10:6-20Proteins10.1002/prot.2319621.10.2011
22014575The Metabolic Regulator ERRalpha, a Downstream Target of HER2/IGF1, as a Therapeutic Target in Breast Cancer.Chang, C-Y.; Kazmin, D.; Jasper, J.S.; Kunder, R.; Zuercher, W.J.; McDonnell, D.P. 20(4):500-10Cancer Cell10.18.2011
22022377Structural basis for specific binding of human MPP8 chromodomain to histone H3 methylated at lysine 9.Li J, Li Z, Ruan J, Xu C, Tong Y, Pan PW, Tempel W, Crombet L, Min J, Zang J6(10):e25104PLoS ONE10.1371/journal.pone.002510412.10.2011
21972038Fluorescence-based methods for screening writers and readers of histone methyl marks.Allali-Hassani A, Wasney GA, Siarheyeva A, Hajian T, Arrowsmith CH, Vedadi M17(1):71-84J Biomol Screen10.1177/108705711142225604.10.2011
21871892Yos9, a control protein for misfolded glycosylated and non-glycosylated proteins in ERAD.Benitez EM, Stolz A, Wolf DH.585(19):3015-9FEBS Lett10.1016/j.febslet.2011.08.02103.10.2011
21605681A centrifugation-free high-throughput protein purification system using in-line microfluidization.Alenkin D, Yermekbayeva L, Mujib S, Vesterberg A, Newman E, Yamazaki K, Cossar D, Dhe-Paganon S79(2):204-9Protein Expr. Purif.10.1016/j.pep.2011.05.00601.10.2011
21741246Cdc48: a power machine in protein degradation.Stolz A, Hilt W, Buchberger A, Wolf DH.36(10):515-23Trends Biochem Sci10.1016/j.tibs.2011.06.00101.10.2011
21958370Cell Function and Antibodies Mediating ADCC in HIV-1-Infected Viremic and Controller PatientsJohansson SE, Rollman E, Chung AW, Center RJ, Hejdeman B, Stratov I, Hinkula J, Wahren B, Karre K, Kent SJ, Berg L. NK 24(5):359-68Viral Immunol10.1089/vim.2011.0025Oct. 2011
Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery.Philpott, M; Yang, J; Tumber, T; Fedorov, O; Uttarkar, S; Filippakopoulos, P; Picaud, S; Keates, T; Felletar, I; Ciulli, A; Knapp, S; Heightman, TD; 7:2899-2908Molecular BioSystems10.1039/c1mb05099k01.10.2011
21962082The Cryptosporidium parvum kinome.Artz JD, Wernimont AK, Allali-Hassani A, Zhao Y, Amani M, Lin YH, Senisterra G, Wasney GA, Fedorov O, King O, Roos A, Lunin VV, Qiu W, Finerty P, Hutchinson A, Chau I, von Delft F, MacKenzie F, Lew J, Kozieradzki I, Vedadi M, Schapira M, Zhang C, Shokat K, Heightman T, Hui R12:478BMC Genomics10.1186/1471-2164-12-47830.09.2011
21947926Zn-binding AZUL domain of human ubiquitin protein ligase Ube3A.Lemak A, Yee A, Bezsonova I, Dhe-Paganon S, Arrowsmith CH51(1-2):185-90J. Biomol. NMR10.1007/s10858-011-9552-y27.09.2011
21966355Oligomeric structure of the MALT1 tandem Ig-like domains.Qiu L, Dhe-Paganon S6(9):e23220PLoS ONE10.1371/journal.pone.002322023.09.2011
21888896Crystal structure of the Cys2His2-type zinc finger domain of human DPF2.Zhang W, Xu C, Bian C, Tempel W, Crombet L, MacKenzie F, Min J, Liu Z, Qi C413(1):58-61Biochem. Biophys. Res. Commun.10.1016/j.bbrc.2011.08.04316.09.2011
21914792Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.Hillringhaus, L; Yue, WW; Rose, NR; Ng, SS; Gileadi, C; Loenarz, C; Bello, SH; Bray, JE; Schofield, CJ; Oppermann, U; 286:41616-41625Journal of Biological Chemistry10.1074/jbc.M111.2836892.12.2011
21933453Bromodomains as therapeutic targets.Muller, S; Filippakopoulos, P; Knapp, S; 13:e29-Expert Reviews in Molecular Medicine10.1017/S146239941100199213.9.2011
21780790Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines.Liu F, Barsyte-Lovejoy D, Allali-Hassani A, He Y, Herold JM, Chen X, Yates CM, Frye SV, Brown PJ, Huang J, Vedadi M, Arrowsmith CH, Jin J54(17):6139-50J. Med. Chem.10.1021/jm200903z08.09.2011
21879452Structural biology of human metal-dependent histone deacetylases.Schapira M206:225-40Handb Exp Pharmacol10.1007/978-3-642-21631-2_1001.09.2011
21896658Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair.Wang, AT; Sengerová, B; Cattell, E; Inagawa, T; Hartley, JM; Kiakos, K; Burgess-Brown, NA; Swift, LP; Enzlin, JH; Schofield, CJ; Gileadi, O; Hartley, JA; McHugh, PJ; 25:1859-1870Genes and Development10.1101/gad.156992111.9.2011
21618462Blockade of NKG2D ameliorates disease in mice with collagen-induced arthritis: a potential pathogenic role in chronic inflammatory arthritis.Andersson, AK; Sumariwalla, PF; McCann, FE; Amjadi, P; Chang, C; McNamee, K; Tornehave, D; Haase, C; Agersø, H; Stennicke, VW; Ahern, D; Ursø, B; Trowsdale, J; Feldmann, M; Brennan, FM; 63:2617-2629Arthritis and Rheumatism10.1002/art.3046001.9.2011
Human SNM1a and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repairWang, AT; Sengerová, B; Cattell, E; Inagawa, T; Hartley, JM; Kiakos, K; Burgess-Brown, NA; Swift, LP; Enzlin, JH; Schofield, CJ; Gileadi, O; Hartley, JA; McHugh, PJ; 25:1859-1870Genes and Development10.1101/gad.156992111.9.2011
21699246Normalizing molecular docking rankings using virtually generated decoys.Wallach I, Jaitly N, Nguyen K, Schapira M, Lilien R51(8):1817-30J Chem Inf Model10.1021/ci200175h22.08.2011
21966348Structural Chemistry of Human SET Domain Protein Methyltransferases.Schapira M5(Suppl 1):85-94Curr Chem Genomics10.2174/187539730100501008522.08.2011
218510573,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands.Hewings, DS; Wang, M; Philpott, M; Fedorov, O; Uttarkar, S; Filippakopoulos, P; Picaud, S; Vuppusetty, C; Marsden, B; Knapp, S; Conway, SJ; Heightman, TD; 54:6761-6770Journal of Medicinal Chemistry10.1021/jm200640v01.10.2011
21853016Characterization of 14-3-3 proteins from Cryptosporidium parvum.Brokx SJ, Wernimont AK, Dong A, Wasney GA, Lin YH, Lew J, Vedadi M, Lee WH, Hui R6(8):e14827PLoS ONE10.1371/journal.pone.001482711.08.2011
21804994Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery.Philpott, M; Yang, J; Tumber, T; Fedorov, O; Uttarkar, S; Filippakopoulos, P; Picaud, S; Keates, T; Felletar, I; Ciulli, A; Knapp, S; Heightman, TD; 7:2899-2908Molecular BioSystems10.1039/c1mb05099k01.10.2011
21802008High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.Miduturu, CV; Deng, X; Kwiatkowski, N; Yang, W; Brault, L; Filippakopoulos, P; Chung, E; Yang, Q; Schwaller, J; Knapp, S; King, RW; Lee, J-D; Herrgard, S; Zarrinkar, P; Gray, NS; 18:868-879Cell Chemistry Biology10.1016/j.chembiol.2011.05.01029.7.2011
21566081Ligand-dependent regulation of the activity of the orphan nuclear receptor, Small Heterodimer Partner (SHP), in the repression of the hepatic bile acid biosynthetic CYP7A1 and CYP8B1 genes.Mol Endocrinol.10.1210/me.2011-003307.25.2011
21610070Structural basis of Rnd1 binding to plexin Rho GTPase binding domains (RBDs).Wang H, Hota PK, Tong Y, Li B, Shen L, Nedyalkova L, Borthakur S, Kim S, Tempel W, Buck M, Park HW286(29):26093-106J. Biol. Chem.10.1074/jbc.M110.19705322.07.2011
21685874Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation.Bian C, Xu C, Ruan J, Lee KK, Burke TL, Tempel W, Barsyte D, Li J, Wu M, Zhou BO, Fleharty BE, Paulson A, Allali-Hassani A, Zhou JQ, Mer G, Grant PA, Workman JL, Zang J, Min J30(14):2829-42EMBO J.10.1038/emboj.2011.19320.07.2011
21743462A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.Vedadi M, Barsyte-Lovejoy D, Liu F, Rival-Gervier S, Allali-Hassani A, Labrie V, Wigle TJ, Dimaggio PA, Wasney GA, Siarheyeva A, Dong A, Tempel W, Wang SC, Chen X, Chau I, Mangano TJ, Huang XP, Simpson CD, Pattenden SG, Norris JL, Kireev DB, Tripathy A, Edwards A, Roth BL, Janzen WP, Garcia BA, Petronis A, Ellis J, Brown PJ, Frye SV, Arrowsmith CH, Jin J7(8):566-74Nat. Chem. Biol.10.1038/nchembio.59910.07.2011
21743469Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.Evans, DM; Spencer, CCA; Pointon, JJ; Su, Z; Harvey, D; Kochan, G; Oppermann, U; Dilthey, A; Pirinen, M; Stone, MA; Appleton, L; Moutsianas, L; Leslie, S; Wordsworth, T; Kenna, TJ; Karaderi, T; Thomas, GP; Ward, MM; Weisman, MH; Farrar, C; Bradbury, LA; Danoy, P; Inman, RD; Maksymowych, W; Gladman, D; Rahman, P; Spondyloarthritis Research Consortium of Canada (SPARCC), ; Morgan, A; Marzo-Ortega, H; Bowness, P; Gaffney, K; Gaston, JSH; Smith, M; Bruges-Armas, J; Couto, A-R; Sorrentino, R; Paladini, F; Ferreira, MA; Xu, H; Liu, Y; Jiang, L; Lopez-Larrea, C; Díaz-Peña, R; López-Vázquez, A; Zayats, T; Band, G; Bellenguez, C; Blackburn, H; Blackwell, JM; Bramon, E; Bumpstead, SJ; Casas, JP; Corvin, A; Craddock, N; Deloukas, P; Dronov, S; Duncanson, A; Edkins, S; Freeman, C; Gillman, M; Gray, E; Gwilliam, R; Hammond, N; Hunt, SE; Jankowski, J; Jayakumar, A; Langford, C; Liddle, J; Markus, HS; Mathew, CG; McCann, OT; McCarthy, MI; Palmer, CNA; Peltonen, L; Plomin, R; Potter, SC; Rautanen, A; Ravindrarajah, R; Ricketts, M; Samani, N; Sawcer, SJ; Strange, A; Trembath, RC; Viswanathan, AC; Waller, M; Weston, P; Whittaker, P; Widaa, S; Wood, NW; McVean, G; Reveille, JD; Wordsworth, BP; Brown, MA; Donnelly, P; Australo-Anglo-American Spondyloarthritis Consortium (TASC), ; Wellcome Trust Case Control Consortium 2 (WTCCC2), ; 43:761-767Nature Genetics10.1038/ng.87310.7.2011
21489993Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein.Nady N, Lemak A, Walker JR, Avvakumov GV, Kareta MS, Achour M, Xue S, Duan S, Allali-Hassani A, Zuo X, Wang YX, Bronner C, Chédin F, Arrowsmith CH, Dhe-Paganon S286(27):24300-11J. Biol. Chem.10.1074/jbc.M111.23410408.07.2011
21732481PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming.Zhang Z, Jones A, Sun CW, Li C, Chang CW, Joo HY, Dai Q, Mysliwiec MR, Wu LC, Guo Y, Yang W, Liu K, Pawlik KM, Erdjument-Bromage H, Tempst P, Lee Y, Min J, Townes TM, Wang H29(2):229-40Stem Cells10.1002/stem.57807.07.2011
21941108Composition, recruitment and regulation of the PRC2 complex.Nayak V, Xu C, Min J2(4):277-82Nucleus10.4161/nucl.2.4.1626601.07.2011
22187664RNAi-mediated knockdown of α-enolase increases the sensitivity of tumor cells to antitubulin chemotherapeuticsGeorges E, Bonneau AM, Prinos P2(4):303-8Int J Biochem Mol Biol2011
21968505Mutation of cysteine 21 inhibits nucleophosmin/B23 oligomerization and chaperone activityPrinos P, Lacoste MC, Wong J, Bonneau AM, Georges, E. 2(1): 24-30Int J Biochem Mol Biol2011
21683433An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, Cox S, Xu S, Lopez-Girona A, Mercurio F, Wrana J, Durocher D, Meloche S, Webb DR, Tyers M, Sicheri F145(7):1075-87Cell10.1016/j.cell.2011.05.03924.06.2011
21615147Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.Debdab, M; Carreaux, F; Renault, S; Soundararajan, M; Fedorov, O; Filippakopoulos, P; Lozach, O; Babault, L; Tahtouh, T; Baratte, B; Ogawa, Y; Hagiwara, M; Eisenreich, A; Rauch, U; Knapp, S; Meijer, L; Bazureau, J-P; 54:4172-4186Journal of Medicinal Chemistry10.1021/jm200274d01.6.2011
21697527Leveraging crowdsourcing to facilitate the discovery of new medicines.Norman TC, Bountra C, Edwards AM, Yamamoto KR, Friend SH3(88):88mr1Sci Transl Med10.1126/scitranslmed.300267822.06.2011
21636783Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system.Strushkevich N, MacKenzie F, Cherkesova T, Grabovec I, Usanov S, Park HW108(25):10139-43Proc. Natl. Acad. Sci. U.S.A.10.1073/pnas.101944110821.06.2011
21720545Structural and histone binding ability characterizations of human PWWP domains.Wu H, Zeng H, Lam R, Tempel W, Amaya MF, Xu C, Dombrovski L, Qiu W, Wang Y, Min J6(6):e18919PLoS ONE10.1371/journal.pone.001891920.06.2011
21552259SYK alternative splicing regulates mitosis and cancer cell survivalPrinos P, Garneau D, Lucier JF, Gendron D, Couture S, Boivin M, Brosseau JP, Lapointe E, Thibault P, Durand M, Tremblay K, Gervais-Bird J, Nwilati H, Klinck R, Chabot B, Perreault JP, Wellinger RJ, Elela SA.18(6):673-9Nat Struct Mol Biol10.1038/nsmb.204006.18.2011
21306906After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders.Huber, K; Superti-Furga, G; 19:3616-3624Bioorganic and Medicinal Chemistry10.1016/j.bmc.2011.01.01801.6.2011
21689687Characterization of a new phosphatase from Plasmodium.Hills T, Srivastava A, Ayi K, Wernimont AK, Kain K, Waters AP, Hui R, Pizarro JC179(2):69-79Mol. Biochem. Parasitol.10.1016/j.molbiopara.2011.06.00113.06.2011
21553822Engineering an antibiotic to fight cancer: Optimization of the novobiocin scaffold to produce anti-proliferative agentsZhao, H; Donnelly, A. C.; Kusuma, B. R.; Brandt, G. E. L.; Brown, D.; Rajewski, R. A.; Vielhauer, G.; Holzbeierlein, J.; Blagg, B. S. J. 3839-3853Med. Chem.10.1021/jm200148p06.09.2011
22019129Accumulation and activation of natural killer cells in local intraperitoneal HIV-1/MuLV infection results in early control of virus infected cellsJohansson SE, Brauner H, Hinkula J, Wahren B, Berg L, Johansson MH. 272(1):71-8Cell Immunol10.1016/j.cellimm.2011.09.0052011
21340633High-throughput structural biology of metabolic enzymes and its impact on human diseases.Yue, WW; Oppermann, U; 34:575-581Journal of Inherited Metabolic Disease10.1007/s10545-011-9296-601.6.2011
21585201A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases.Luo, X; Liu, Y; Kubicek, S; Myllyharju, J; Tumber, A; Ng, S; Che, KH; Podoll, J; Heightman, TD; Oppermann, U; Schreiber, SL; Wang, X; 133:9451-9456Journal of the American Chemical Society10.1021/ja201597b22.6.2011
21572409A roadmap to generate renewable protein binders to the human proteome.Colwill K, Gräslund S8(7):551-8Nat. Methods10.1038/nmeth.160715.05.2011
New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights (September, pg 3175, 2010)Lopez-Ramos, M; Prudent, R; Moucadel, V; Sautel, CF; Barette, C; Lafanechere, L; Mouawad, L; Grierson, D; Schmidt, F; Florent, J-C; Filippakopoulos, P; Bullock, AN; Knapp, S; Reiser, J-B; Cochet, C; 25:1775-1775FASEB Journal10.1096/fj.09-143743err01.5.2011
21195614Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: Design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinenceAndrews, MD; Fish, PV; Blagg, J; Brabham, TK; Brennan, PE; Bridgeland, A; Brown, AD; Bungay, PJ; Conlon, KM; Edmunds, NJ; af Forselles, K; Gibbons, CP; Green, MP; Hanton, G; Holbrook, M; Jessiman, AS; McIntosh, K; McMurray, G; Nichols, CL; Root, JA; Storer, RI; Sutton, MR; Ward, RV; Westbrook, D; Whitlock, GA; 21:2715-2720Bioorganic and Medicinal Chemistry Letters10.1016/j.bmcl.2010.11.12001.5.2011
21525647Assessment of radiation damage behaviour in a large collection of empirically optimized datasets highlights the importance of unmeasured complicating effects.Krojer, T; von Delft, F; 18:387-397Journal of Synchrotron Radiation10.1107/S090904951100823501.5.2011
21389349The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1.Syeda F, Fagan RL, Wean M, Avvakumov GV, Walker JR, Xue S, Dhe-Paganon S, Brenner C286(17):15344-51J. Biol. Chem.10.1074/jbc.M110.20988229.04.2011
21531872Characterization, localization, essentiality, and high-resolution crystal structure of glucosamine 6-phosphate N-acetyltransferase from Trypanosoma brucei.Mariño K, Güther ML, Wernimont AK, Qiu W, Hui R, Ferguson MA10(7):985-97Eukaryotic Cell10.1128/EC.05025-1129.04.2011
21362626Structure and biochemical functions of SIRT6.Pan PW, Feldman JL, Devries MK, Dong A, Edwards AM, Denu JM286(16):14575-87J. Biol. Chem.10.1074/jbc.M111.21899022.04.2011
21530488Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase.Zhang, Z; Kochan, GT; Ng, SS; Kavanagh, KL; Oppermann, U; Schofield, CJ; McDonough, MA; 408:553-558Biochemical and Biophysical Research Communications10.1016/j.bbrc.2011.04.05920.5.2011
21509537Interactive JIMD articles using the iSee concept: turning a new page on structural biology dataLee, WH; Yue, WW; Raush, E; Totrov, M; Abagyan, R; Oppermann, U; Marsden, BD; :1-3Journal of Inherited Metabolic Disease10.1007/s10545-011-9334-421.4.2011
21508329Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming.Kochan, G; Krojer, T; Harvey, D; Fischer, R; Chen, L; Vollmar, M; von Delft, F; Kavanagh, KL; Brown, MA; Bowness, P; Wordsworth, P; Kessler, BM; Oppermann, U; 108:7745-7750Proceedings of the National Academy of Sciences10.1073/pnas.110126210810.5.2011
21502315Structure and mechanism of human UDP-glucose 6-dehydrogenase.Egger, S; Chaikuad, A; Kavanagh, KL; Oppermann, U; Nidetzky, B; 286:23877-23887Journal of Biological Chemistry10.1074/jbc.M111.2346828.7.2011
BET bromodomain inhibitors for cancer therapyQi, J; Filippakopoulos, P; McKeown, M; Shaw, KL; Smith, WB; French, CA; Kung, AL; Knapp, S; Bradner, JE; 71:-Cancer Research10.1158/1538-7445.AM2011-231815.4.2011
21417280Small-molecule ligands of methyl-lysine binding proteins.Herold JM, Wigle TJ, Norris JL, Lam R, Korboukh VK, Gao C, Ingerman LA, Kireev DB, Senisterra G, Vedadi M, Tripathy A, Brown PJ, Arrowsmith CH, Jin J, Janzen WP, Frye SV54(7):2504-11J. Med. Chem.10.1021/jm200045v14.04.2011
21497677The relationship between the chemistry and biological activity of the bisphosphonates.Ebetino, FH; Hogan, A-ML; Sun, S; Tsoumpra, MK; Duan, X; Triffitt, JT; Kwaasi, AA; Dunford, JE; Barnett, BL; Oppermann, U; Lundy, MW; Boyde, A; Kashemirov, BA; McKenna, CE; Russell, RGG; 49:20-33BONE10.1016/j.bone.2011.03.77401.7.2011
21468892Structure and function of WD40 domain proteins.Xu C, Min J2(3):202-14Protein Cell10.1007/s13238-011-1018-106.04.2011
21399617Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21.Ye Y, Akutsu M, Reyes-Turcu F, Enchev RI, Wilkinson KD, Komander D.12(4):350-7EMBO Rep10.1038/embor.2011.1701.04.2011
21325490Increased Cell-Mediated Immune Responses in Patients with Recurrent Herpes Simplex Virus Type 2 MeningitisFranzen-Rohl E, Schepis D, Lagrelius M, Franck K, Jones P, Liljeqvist JA, Bergstrom T, Aurelius E, Karre K, Berg L, Gaines H. 18(4):655-60Clin Vaccine Immunol10.1128/CVI.00333-1001.04.2011
21761332Breast cancer stem cells and their role in resistance to endocrine therapy.O'Brien, CS; Farnie, G; Howell, SJ; Clarke, RB; 2:91-103Hormones and Cancer10.1007/s12672-011-0066-601.4.2011
21446733Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitorsFeng, L; Geisselbrecht, Y; Blanck, S; Wilbuer, A; Atilla-Gokcumen, GE; Filippakopoulos, P; Kräling, K; Celik, MA; Harms, K; Maksimoska, J; Marmorstein, R; Frenking, G; Knapp, S; Essen, LO; Meggers, E; 133:5976-5986Journal of the American Chemical Society10.1021/ja111299620.4.2011
21451121The precompetitive space: time to move the yardsticks.Norman T, Edwards A, Bountra C, Friend S3(76):76cm10Sci Transl Med10.1126/scitranslmed.300239930.03.2011
21445611Structural basis of fumarate hydratase deficiency.Picaud, S; Kavanagh, KL; Yue, WW; Lee, WH; Muller-Knapp, S; Gileadi, O; Sacchettini, J; Oppermann, U; 34:671-676Journal of Inherited Metabolic Disease10.1007/s10545-011-9294-801.6.2011
21366357Structural chemistry of the histone methyltransferases cofactor binding site.Campagna-Slater V, Mok MW, Nguyen KT, Feher M, Najmanovich R, Schapira M51(3):612-23J Chem Inf Model10.1021/ci100479z28.03.2011
21417343Crystal structures of ABL-related gene (ABL2) in complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class.Salah, E; Ugochukwu, E; Barr, AJ; von Delft, F; Knapp, S; Elkins, JM; 54:2359-2367Journal of Medicinal Chemistry10.1021/jm101506n14.4.2011
21407193The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain.Xu C, Bian C, Lam R, Dong A, Min J2:227Nat Commun10.1038/ncomms123717.03.2011
21397192Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53.Liao JC, Lam R, Brazda V, Duan S, Ravichandran M, Ma J, Xiao T, Tempel W, Zuo X, Wang YX, Chirgadze NY, Arrowsmith CH19(3):418-29Structure10.1016/j.str.2010.12.01509.03.2011
20942778Fetal and adult multipotent mesenchymal stromal cells are killed by different pathwaysGotherstrom C, Lundqvist A, Duprez IR, Childs R, Berg L, le Blanc K. 13(3):269-78Cytotherapy10.3109/14653249.2010.523077March 2011
21190999Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.Yap DB, Chu J, Berg T, Schapira M, Cheng SW, Moradian A, Morin RD, Mungall AJ, Meissner B, Boyle M, Marquez VE, Marra MA, Gascoyne RD, Humphries RK, Arrowsmith CH, Morin GB, Aparicio SA117(8):2451-9Blood10.1182/blood-2010-11-32120824.02.2011
21326229Structural basis for the recognition and cleavage of histone H3 by cathepsin L.Adams-Cioaba MA, Krupa JC, Xu C, Mort JS, Min J2:197Nat Commun10.1038/ncomms120418.02.2011
21084285Structural and functional comparison of the RING domains of two p53 E3 ligases, Mdm2 and Pirh2.Shloush J, Vlassov JE, Engson I, Duan S, Saridakis V, Dhe-Paganon S, Raught B, Sheng Y, Arrowsmith CH286(6):4796-808J. Biol. Chem.10.1074/jbc.M110.15766911.02.2011
21308845A secretory system for bacterial production of high-profile protein targets.Kotzsch A, Vernet E, Hammarström M, Berthelsen J, Weigelt J, Gräslund S, Sundström M20(3):597-609Protein Sci.10.1002/pro.59311.02.2011
21307913Too many roads not taken.Edwards AM, Isserlin R, Bader GD, Frye SV, Willson TM, Yu FH470(7333):163-5Nature10.1038/470163a10.02.2011
A tandem asymmetric synthesis approach for the efficient preparation of enantiomerically pure 9-(hydroxyethyl) anthraceneBall, JC; Brennan, P; Elsunaki, TM; Jaunet, A; Jones, S; 22:253-255Tetrahedron: Asymmetry10.1016/j.tetasy.2011.01.01910.2.2011
21266548Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains.Akutsu M, Ye Y, Virdee S, Chin JW, Komander D.108(6):2228-33Proc Natl Acad Sci U S A10.1073/pnas.101528710808.02.2011
21084289Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites.Artz JD, Wernimont AK, Dunford JE, Schapira M, Dong A, Zhao Y, Lew J, Russell RG, Ebetino FH, Oppermann U, Hui R286(5):3315-22J. Biol. Chem.10.1074/jbc.M109.02723504.02.2011
21335238DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramerDeutsch, GB; Zielonka, EM; Coutandin, D; Weber, TA; Schäfer, B; Hannewald, J; Luh, LM; Durst, FG; Ibrahim, M; Hoffmann, J; Niesen, FH; Sentürk, A; Kunkel, H; Brutschy, B; Schleiff, E; Knapp, S; Acker-Palmer, A; Grez, M; McKeon, F; Dötsch, V; 144:566-576Cell10.1016/j.cell.2011.01.01318.2.2011
A general and mild two-step procedure for the synthesis of aryl and heteroaryl sulfonamides from the corresponding iodidesHo, DKH; Chan, L; Hooper, A; Brennan, PE; 52:820 - 823-820 - 823Tetrahedron Letters10.1016/j.tetlet.2010.12.05001.01.2011
21969122DNA methyl transferase 1: regulatory mechanisms and implications in health and disease.Dhe-Paganon S, Syeda F, Park L2(1):58-66Int J Biochem Mol Biol30.01.2011
21276940Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing.Fedorov, O; Huber, K; Eisenreich, A; Filippakopoulos, P; King, O; Bullock, AN; Szklarczyk, D; Jensen, LJ; Fabbro, D; Trappe, J; Rauch, U; Bracher, F; Knapp, S; 18:67-76Cell Chemistry Biology10.1016/j.chembiol.2010.11.00901.1.2011
21269272Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDS.Chaikuad, A; Shafqat, N; Al-Mokhtar, R; Cameron, G; Clarke, AR; Brady, RL; Oppermann, U; Frayne, J; Yue, WW; 435:401-409Biochemical Journal10.1042/BJ2010144215.4.2011
21257746Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases.Chen, D; Vollmar, M; Rossi, MN; Phillips, C; Kraehenbuehl, R; Slade, D; Mehrotra, PV; von Delft, F; Crosthwaite, SK; Gileadi, O; Denu, JM; Ahel, I; 286:13261-13271Journal of Biological Chemistry10.1074/jbc.M110.20677115.4.2011
21225415Animal models of epigenetic regulation in neuropsychiatric disorders.Bountra, C; Oppermann, U; Heightman, TD; 7:281-322Current topics in behavioral neurosciences10.1007/7854_2010_10401.01.2011
21047797Recognition and specificity determinants of the human cbx chromodomains.Kaustov L, Ouyang H, Amaya M, Lemak A, Nady N, Duan S, Wasney GA, Li Z, Vedadi M, Schapira M, Min J, Arrowsmith CH286(1):521-9J. Biol. Chem.10.1074/jbc.M110.19141107.01.2011
DELINEATING THE MITOCHONDRIAL VITAMIN B12 PATHWAY THROUGH STRUCTURAL AND INTERACTION STUDIESFroese, DS; Kochan, G; Muniz, JRC; Chaikuad, A; Wu, X; Gileadi, C; Ugochukwu, E; Krysztofinska, E; Gravel, RA; Oppermann, U; Yue, WW; 34:S119-S119Journal of Inherited Metabolic Disease01.01.2011
INTERACTIVE 3D VISUALISATIONS OF PROTEIN STRUCTURES TO AID THE STUDY OF INBORN ERRORS OF METABOLISMLee, WH; Raush, E; Totrov, M; Abagyan, R; Marsden, BD; Oppermann, U; Yue, WW; 34:S240-S240Journal of Inherited Metabolic Disease01.01.2011
21129982A systematic protocol for the characterization of Hsp90 modulatorsMatts, R. L.; Brandt, G. E.; Lu, Y.; Dixit, A.; Mollapour, M.; Wang, S.; Donnelly, A. C.; Neckers, L.; Verkhivker, G.; Blagg, B. S.684-92Med. Chem. Lett. 10.1016/j.bmc.2010.10.02901.01.2011
21131908Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2.Newstead, S; Drew, D; Cameron, AD; Postis, VLG; Xia, X; Fowler, PW; Ingram, JC; Carpenter, EP; Sansom, MSP; McPherson, MJ; Baldwin, SA; Iwata, S; 30:417-426EMBO Journal10.1038/emboj.2010.30919.1.2011
21119616Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein.Carr, SM; Munro, S; Kessler, B; Oppermann, U; La Thangue, NB; 30:317-327EMBO Journal10.1038/emboj.2010.31119.1.2011
21093405High-performance liquid chromatography separation and intact mass analysis of detergent-solubilized integral membrane proteins.Berridge, G; Chalk, R; D'Avanzo, N; Dong, L; Doyle, D; Kim, J-I; Xia, X; Burgess-Brown, N; Deriso, A; Carpenter, EP; Gileadi, O; 410:272-280Analytical Biochemistry10.1016/j.ab.2010.11.00815.3.2011
21059676A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation.Lucic, B; Zhang, Y; King, O; Mendoza-Maldonado, R; Berti, M; Niesen, FH; Burgess-Brown, NA; Pike, ACW; Cooper, CDO; Gileadi, O; Vindigni, A; 39:1703-1717Nucleic Acids Research10.1093/nar/gkq103101.3.2011
21029046The crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activity.Johansson, C; Roos, AK; Montano, SJ; Sengupta, R; Filippakopoulos, P; Guo, K; von Delft, F; Holmgren, A; Oppermann, U; Kavanagh, KL; 433:303-311Biochemical Journal10.1042/BJ2010128615.1.2011
21044902A novel ACVR1 mutation in the glycine/serine-rich domain found in the most benign case of a fibrodysplasia ossificans progressiva variant reported to date.Gregson, CL; Hollingworth, P; Williams, M; Petrie, KA; Bullock, AN; Brown, MA; Tobias, JH; Triffitt, JT; 48:654-658BONE10.1016/j.bone.2010.10.1641.3.2011
21030588Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase.Zadjali, F; Pike, ACW; Vesterlund, M; Sun, J; Wu, C; Li, SSC; Rönnstrand, L; Knapp, S; Bullock, AN; Flores-Morales, A; 286:480-490Journal of Biological Chemistry10.1074/jbc.M110.1735267.1.2011
20835842Kinetic and structural evidence of the alkenal/one reductase specificity of human ζ-crystallin.Porté, S; Moeini, A; Reche, I; Shafqat, N; Oppermann, U; Farrés, J; Parés, X; 68:1065-1077Cellular and Molecular Life Sciences10.1007/s00018-010-0508-201.3.2011
21168767Structural and mechanistic studies on gamma-butyrobetaine hydroxylase.Leung IK,Krojer TJ,Kochan GT,Henry L,von Delft F,Claridge TD,Oppermann U,McDonough MA,Schofield CJ. 17(12):1316-1324Chemistry & biologyhttp://dx.doi.org/10.1016/j.chembiol.2010.09.016 22/12/2010
21168767Structural and mechanistic studies on γ-butyrobetaine hydroxylase.Leung, IKH; Krojer, TJ; Kochan, GT; Henry, L; von Delft, F; Claridge, TDW; Oppermann, U; McDonough, MA; Schofield, CJ; 17:1316-1324Cell Chemistry Biology10.1016/j.chembiol.2010.09.01622.12.2010
21147463Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence.Fentress SJ, Behnke MS, Dunay IR, Mashayekhi M, Rommereim LM, Fox BA, Bzik DJ, Taylor GA, Turk BE, Lichti CF, Townsend RR, Qiu W, Hui R, Beatty WL, Sibley LD8(6):484-95Cell Host Microbe10.1016/j.chom.2010.11.00516.12.2010
Deceleration of theE1P-E2P Transition and Ion Transport by Mutation of Potentially Salt Bridge-forming Residues Lys-791 and Glu-820 in Gastric H+/K+-ATPaseDürr, KL; Seuffert, I; Friedrich, T; 285:39366-39379Journal of Biological Chemistry10.1074/jbc.m110.13347010.12.2010
21135177Newly discovered and characterized antivirulence compounds inhibit bacterial mono-ADP-ribosyltransferase toxins.Turgeon Z, Jørgensen R, Visschedyk D, Edwards PR, Legree S, McGregor C, Fieldhouse RJ, Mangroo D, Schapira M, Merrill AR55(3):983-91Antimicrob. Agents Chemother.10.1128/AAC.01164-1006.12.2010
21287613Structures of parasitic CDPK domains point to a common mechanism of activation.Wernimont AK, Amani M, Qiu W, Pizarro JC, Artz JD, Lin YH, Lew J, Hutchinson A, Hui R79(3):803-20Proteins10.1002/prot.2291903.12.2010
20887733The Clp chaperones and proteases of the human malaria parasite Plasmodium falciparum.El Bakkouri M, Pow A, Mulichak A, Cheung KL, Artz JD, Amani M, Fell S, de Koning-Ward TF, Goodman CD, McFadden GI, Ortega J, Hui R, Houry WA404(3):456-77J. Mol. Biol.10.1016/j.jmb.2010.09.05103.12.2010
20876572Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation.Froese, DS; Kochan, G; Muniz, JRC; Wu, X; Gileadi, C; Ugochukwu, E; Krysztofinska, E; Gravel, RA; Oppermann, U; Yue, WW; 285:38204-38213Journal of Biological Chemistry10.1074/jbc.M110.1777173.12.2010
21057110Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.Tong Y, Tempel W, Wang H, Yamada K, Shen L, Senisterra GA, MacKenzie F, Chishti AH, Park HW107(47):20346-51Proc. Natl. Acad. Sci. U.S.A.10.1073/pnas.100900810723.11.2010
The PIM Kinase Inhibitor K00135 Sensitizes Primary Acute Lymphoblastic Leukaemia (ALL) Cells to DNA-Damaging AgentsDa Costa, D; Weston, VJ; Knapp, S; Taylor, AMR; Kearns, PR; Stankovic, T; 116:1328-1328Blood19.11.2010
Whole Kinome Profiling In Pediatric Acute LeukemiaGombert, M; Krell, PFI; Linka, RM; Knapp, S; Borkhardt, A; 116:453-453Blood19.11.2010
Whole Kinome Profiling In Pediatric Acute LeukemiaKrell, PFI; Linka, RM; Knapp, S; Borkhardt, A; 116:453-453Blood19.11.2010
High-performance liquid chromatography separation and intact mass analysis of detergent-solubilized integral membrane proteinsBerridge, G; Chalk, R; Burgess-Brown, NA; Carpenter, EP; Gileadi, O; :-Analytical Biochemistry10.1016/j.ab.2010.11.00817.11.2010
21045140Breast cancer stem cells: something out of notching?Harrison, H; Farnie, G; Brennan, KR; Clarke, RB; 70:8973-8976Cancer Research10.1158/0008-5472.can-10-15592.11.2010
20826778Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity.Ko S, Kang GB, Song SM, Lee JG, Shin DY, Yun JH, Sheng Y, Cheong C, Jeon YH, Jung YK, Arrowsmith CH, Avvakumov GV, Dhe-Paganon S, Yoo YJ, Eom SH, Lee W285(46):36070-80J. Biol. Chem.10.1074/jbc.M110.14521912.11.2010
20974918Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2).Xu C, Bian C, Yang W, Galka M, Ouyang H, Chen C, Qiu W, Liu H, Jones AE, MacKenzie F, Pan P, Li SS, Wang H, Min J107(45):19266-71Proc. Natl. Acad. Sci. U.S.A.10.1073/pnas.100893710709.11.2010
21072205Regulation and cytoprotective role of hexokinase III.Wyatt E, Wu R, Rabeh W, Park HW, Ghanefar M, Ardehali H5(11):e13823PLoS ONE10.1371/journal.pone.001382303.11.2010
21072162Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2.Adams-Cioaba MA, Guo Y, Bian C, Amaya MF, Lam R, Wasney GA, Vedadi M, Xu C, Min J5(11):e13559PLoS ONE10.1371/journal.pone.001355902.11.2010
20455075Biodegradation of bisphenol A and its halogenated analogues by Cunninghamella elegans ATCC36112.Keum YS, Lee HR, Park HW, Kim JH21(6):989-97Biodegradation10.1007/s10532-010-9358-801.11.2010
A Versatile Synthesis of 3-Substituted 4-Cyano-1,2,3,4-tetrahydro-1-oxo-beta-carbolinesHuber, K; Kast, O; Bracher, F; :3849-3854SYNTHESIS10.1055/s-0030-125828201.11.2010
20937909Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain.Liu K, Chen C, Guo Y, Lam R, Bian C, Xu C, Zhao DY, Jin J, MacKenzie F, Pawson T, Min J107(43):18398-403Proc. Natl. Acad. Sci. U.S.A.10.1073/pnas.101310610726.10.2010
20739309Structural genomics of histone tail recognition.Wang M, Mok MW, Harper H, Lee WH, Min J, Knapp S, Oppermann U, Marsden B, Schapira M26(20):2629-30Bioinformatics10.1093/bioinformatics/btq49115.10.2010
20804180A Rapid Three-Component MgI2 Mediated Synthesis of 3,3-Pyrrolidinyl SpirooxindolesHelan, V.; Mills, A.; Drewry, D.; Grant, D. 6693-5J Org Chem.10.1021/jo101077g10.01.2010
20579315Dfm1 forms distinct complexes with Cdc48 and the ER ubiquitin ligases and is required for ERAD.Stolz A, Schweizer RS, Schäfer A, Wolf DH.11(10):1363-9Traffic10.1111/j.1600-0854.2010.01093.x01.10.2010
20731674Characterization of long-term mixed donor-donor chimerism after double cord blood transplantationGertow J, Berglund S, Okas M, Uzunel M, Berg L, Karre K, Mattsson J, Uhlin M162(1):146-5Clin Exp Immunol.10.1111/j.1365-2249.2010.04212.x2010 Oct.
20863317UDP-glucose dehydrogenase: structure and function of a potential drug target.Egger, S; Chaikuad, A; Kavanagh, KL; Oppermann, U; Nidetzky, B; 38:1378-1385Biochemical Society Transactions10.1042/BST038137801.10.2010
20941364Comparative structural analysis of human DEAD-box RNA helicases.Schütz P, Karlberg T, van den Berg S, Collins R, Lehtiö L, Högbom M, Holmberg-Schiavone L, Tempel W, Park HW, Hammarström M, Moche M, Thorsell AG, Schüler H5(9):PLoS ONE10.1371/journal.pone.001279130.09.2010
20871596Selective inhibition of BET bromodomains.Filippakopoulos, P; Qi, J; Picaud, S; Shen, Y; Smith, WB; Fedorov, O; Morse, EM; Keates, T; Hickman, TT; Felletar, I; Philpott, M; Munro, S; McKeown, MR; Wang, Y; Christie, AL; West, N; Cameron, MJ; Schwartz, B; Heightman, TD; La Thangue, N; French, CA; Wiest, O; Kung, AL; Knapp, S; Bradner, JE; 468:1067-1073Nature10.1038/nature0950401.12.2010
20856875The crystal structure of Toxoplasma gondii pyruvate kinase 1.Bakszt R, Wernimont A, Allali-Hassani A, Mok MW, Hills T, Hui R, Pizarro JC5(9):e12736PLoS ONE10.1371/journal.pone.001273614.09.2010
20837706MOF and H4 K16 acetylation play important roles in DNA damage repair by modulating recruitment of DNA damage repair protein Mdc1.Li X, Corsa CA, Pan PW, Wu L, Ferguson D, Yu X, Min J, Dou Y30(22):5335-47Mol. Cell. Biol.10.1128/MCB.00350-1013.09.2010
20835842Kinetic and structural evidence of the alkenal/one reductase specificity of human zeta-crystallin.Porté S, Moeini A, Reche I, Shafqat N, Oppermann U, Farrés J, Parés X. 68(6):1065-1077Cellular and molecular life scienceshttps://doi.org/10.1007/s00018-010-0508-211/09/2010
22823261Targeting kinases for the treatment of inflammatory diseasesMüller, S; Knapp, S; 5:867-881Expert Opinion on Drug Discovery10.1517/17460441.2010.5042031.9.2010
Small-molecule bromodomain inhibitors for cancer therapyQi, J; Filippakopoulos, P; Picaud, S; Smith, W; Keates, T; Morse, E; Philpott, M; Shaw, K; Fedorov, O; West, N; Heightman, T; French, C; Knapp, S; Bradner, J; 240:-ACS National Meeting Book of Abstracts22.8.2010
20724435Identification, subcellular localization, biochemical properties, and high-resolution crystal structure of Trypanosoma brucei UDP-glucose pyrophosphorylase.Mariño K, Güther ML, Wernimont AK, Amani M, Hui R, Ferguson MA20(12):1619-30Glycobiology10.1093/glycob/cwq11519.08.2010
20614940Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.Liu F, Chen X, Allali-Hassani A, Quinn AM, Wigle TJ, Wasney GA, Dong A, Senisterra G, Chau I, Siarheyeva A, Norris JL, Kireev DB, Jadhav A, Herold JM, Janzen WP, Arrowsmith CH, Frye SV, Brown PJ, Simeonov A, Vedadi M, Jin J53(15):5844-57J. Med. Chem.10.1021/jm100478y12.08.2010
20487031Differential regulation of CaMKII inhibitor β protein expression after exposure to a novel context and during contextual fear memory formationRadwańska, K; Tudor-Jones, AA; Mizuno, K; Pereira, GS; Lucchesi, W; Alfano, I; Łach, A; Kaczmarek, L; Knapp, S; Peter Giese, K; 9:648-657Genes, Brain and Behavior10.1111/j.1601-183X.2010.00595.x1.8.2010
Cytotoxic sugar analogues of an optimized novobiocin scaffoldDonnelly, A. C.; Zhao, H.; Kusuma, B. R.; Blagg, B. S. J.165-170Chem. Comm. 07.30.2010
20659682Accessing protein methyltransferase and demethylase enzymology using microfluidic capillary electrophoresis.Wigle TJ, Provencher LM, Norris JL, Jin J, Brown PJ, Frye SV, Janzen WP17(7):695-704Chem. Biol.10.1016/j.chembiol.2010.04.01430.07.2010
20676357Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.Davis TL, Walker JR, Campagna-Slater V, Finerty PJ, Paramanathan R, Bernstein G, MacKenzie F, Tempel W, Ouyang H, Lee WH, Eisenmesser EZ, Dhe-Paganon S8(7):e1000439PLoS Biol.10.1371/journal.pbio.100043927.07.2010
20630857Quinone oxidoreductase-2-mediated prodrug cancer therapy.Middleton, MR; Knox, R; Cattell, E; Oppermann, U; Midgley, R; Ali, R; Auton, T; Agarwal, R; Anderson, D; Sarker, D; Judson, I; Osawa, T; Spanswick, VJ; Davies, S; Hartley, JA; Kerr, DJ; 2:40ra50-Science Translational Medicine10.1126/scitranslmed.300061514.7.2010
IMPACT OF ANKYLOSING SPONDYLITIS-ASSOCIATED ERAP1 VARIANTS ON ITS AMINOPEPTIDASE ACTIVITYHarvey, D; Kochan, G; Pointon, JJ; Oppermann, U; Wordsworth, BP; 28:607-607Clinical and Experimental Rheumatology01.01.2010
INVESTIGATING THE ROLE OF ENDOPLASMIC RETICULUM AMINOPEPTIDASE-1 (ERAP1) IN ANKYLOSING SPONDYLITISChen, L; Fischer, R; Harvey, D; Kollnberger, S; Wordsworth, BP; Oppermann, U; Kessler, B; Bowness, P; 28:631-631Clinical and Experimental Rheumatology01.01.2010
THE GENETICS OF ERAP1 IN ANKYLOSING SPONDYLITISWordsworth, BP; Harvey, D; Pointon, J; Oppermann, U; 28:603-603Clinical and Experimental Rheumatology01.01.2010
20368332Crystal structure of the human ubiquitin-activating enzyme 5 (UBA5) bound to ATP: mechanistic insights into a minimalistic E1 enzyme.Bacik JP, Walker JR, Ali M, Schimmer AD, Dhe-Paganon S285(26):20273-80J. Biol. Chem.10.1074/jbc.M110.10292125.06.2010
20571119Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired.Panigrahi, GB; Slean, MM; Simard, JP; Gileadi, O; Pearson, CE; 107:12593-12598Proceedings of the National Academy of Sciences10.1073/pnas.090908710713.7.2010
20505120Architecture of Eph receptor clusters.Himanen JP, Yermekbayeva L, Janes PW, Walker JR, Xu K, Atapattu L, Rajashankar KR, Mensinga A, Lackmann M, Nikolov DB, Dhe-Paganon S107(24):10860-5Proc. Natl. Acad. Sci. U.S.A.10.1073/pnas.100414810715.06.2010
20561531Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.Filippakopoulos, P; Low, A; Sharpe, TD; Uppenberg, J; Yao, S; Kuang, Z; Savitsky, P; Lewis, RS; Nicholson, SE; Norton, RS; Bullock, AN; 401:389-402Journal of Molecular Biology10.1016/j.jmb.2010.06.01720.8.2010
20413343Enhancements of screening collections to address areas of unmet medical need: an industry perspectiveDrewry, D.H.; Macarron, R.289-298Curr. Opinion in Chem Biol.10.1016/j.cbpa.2010.03.02406.14.2010
20207735Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress.Brocker, C; Lassen, N; Estey, T; Pappa, A; Cantore, M; Orlova, VV; Chavakis, T; Kavanagh, KL; Oppermann, U; Vasiliou, V; 285:18452-18463Journal of Biological Chemistry10.1074/jbc.M109.07792511.6.2010
20541610High-throughput production of human proteins for crystallization: the SGC experience.Savitsky, P; Bray, J; Cooper, CDO; Marsden, BD; Mahajan, P; Burgess-Brown, NA; Gileadi, O; 172:3-13Journal of Structural Biology10.1016/j.jsb.2010.06.00801.10.2010
20443544Structural impact of human and Escherichia coli biotin carboxyl carrier proteins on biotin attachment.Healy, S; McDonald, MK; Wu, X; Yue, WW; Kochan, G; Oppermann, U; Gravel, RA; 49:4687-4694Biochemistry10.1021/bi901612y8.6.2010
20405931Mass spectrometry following mild enzymatic digestion reveals phosphorylation of recombinant proteins in Escherichia coli through mechanisms involving direct nucleotide binding.She YM, Xu X, Yakunin AF, Dhe-Paganon S, Donald LJ, Standing KG, Lee DC, Jia Z, Cyr TD9(6):3311-8J. Proteome Res.10.1021/pr901198704.06.2010
20451379Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase.Jiang JK, Boxer MB, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ20(11):3387-93Bioorg. Med. Chem. Lett.10.1016/j.bmcl.2010.04.01501.06.2010
20219571Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.Stolz A, Wolf DH.1803(6):694-705Biochim Biophys Acta10.1016/j.bbamcr.2010.02.00501.06.2010
20145274PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers.Brault, L; Gasser, C; Bracher, F; Huber, K; Knapp, S; Schwaller, J; 95:1004-1015Haematologica10.3324/haematol.2009.01707901.6.2010
19883803Towards proteome scale antibody selections using phage display.Mersmann M, Meier D, Mersmann J, Helmsing S, Nilsson P, Gräslund S, Colwill K, Hust M, Dübel S27(2):118-28N Biotechnol10.1016/j.nbt.2009.10.00731.05.2010
20684070Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6.Mantri, M; Krojer, T; Bagg, EA; Webby, CJ; Butler, DS; Kochan, G; Kavanagh, KL; Oppermann, U; McDonough, MA; Schofield, CJ; 401:211-222Journal of Molecular Biology13.8.2010
20420387Discovery of GSK1070916, a Potent and Selective Inhibitor of Aurora B/C KinaseAdams, N.D.; Adams, J.L.; Burgess, J.L.; Chaudhari, A.M.; Copeland, R.A.; Donatelli, C.A.; Drewry, D.H.; Fisher, K.E.; Hamajima, T.; Hardwicke, MA.; Huffman, W.F.; Koretke-Brown, K.K.; Lai, Z.V.; McDonald, O.B.; Nakamura, H,; Newlander, K.A.; Oleykowski, C.A.; Parrish, C.A.; Patrick, D.R.; Plant, R.; Sarpong, M.A.; Sasake, K.; Schmidt, S.J.; Silva, D.J.; Sutton, D.; Tang, J.; Thompson, C.S.; Tummino. P.J.; Wang, J.C.; Xiang, H.; Yang, J.; Dhanak, D. 3973-4001J. Med. Chem.10.1021/jm901870q05.27.2010
20299452Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.Hong BS, Allali-Hassani A, Tempel W, Finerty PJ, Mackenzie F, Dimov S, Vedadi M, Park HW285(21):16330-40J. Biol. Chem.10.1074/jbc.M109.03902421.05.2010
20207729Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling.Wiens CJ, Tong Y, Esmail MA, Oh E, Gerdes JM, Wang J, Tempel W, Rattner JB, Katsanis N, Park HW, Leroux MR285(21):16218-30J. Biol. Chem.10.1074/jbc.M109.07095321.05.2010
20494124Superfamilies SDR and MDR: from early ancestry to present forms. Emergence of three lines, a Zn-metalloenzyme, and distinct variabilities.Jörnvall, H; Hedlund, J; Bergman, T; Oppermann, U; Persson, B; 396:125-130Biochemical and Biophysical Research Communications10.1016/j.bbrc.2010.03.09421.5.2010
20485436Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma.Lourido S, Shuman J, Zhang C, Shokat KM, Hui R, Sibley LD465(7296):359-62Nature10.1038/nature0902220.05.2010
20346956Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.Shafqat, N; Turnbull, A; Zschocke, J; Oppermann, U; Yue, WW; 398:497-506Journal of Molecular Biology10.1016/j.jmb.2010.03.03414.5.2010
20466062Biophysical characterization of recombinant proteins: a key to higher structural genomics success.Vedadi M, Arrowsmith CH, Allali-Hassani A, Senisterra G, Wasney GA172(1):107-19J. Struct. Biol.10.1016/j.jsb.2010.05.00511.05.2010
20567762A chemiluminescence-based method for identification of histone lysine methyltransferase inhibitors.Quinn AM, Allali-Hassani A, Vedadi M, Simeonov A6(5):782-8Mol Biosyst10.1039/b921912a10.05.2010
20436473Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium.Wernimont AK, Artz JD, Finerty P, Lin YH, Amani M, Allali-Hassani A, Senisterra G, Vedadi M, Tempel W, Mackenzie F, Chau I, Lourido S, Sibley LD, Hui R17(5):596-601Nat. Struct. Mol. Biol.10.1038/nsmb.179502.05.2010
20423462Classification of the short-chain dehydrogenase/reductase superfamily using hidden Markov models.Kallberg, Y; Oppermann, U; Persson, B; 277:2375-2386European Journal of Biochemistry10.1111/j.1742-4658.2010.07656.x01.5.2010
20219402Thermolability of mutant MMACHC protein in the vitamin B12-responsive cblC disorder.Froese, DS; Healy, S; McDonald, M; Kochan, G; Oppermann, U; Niesen, FH; Gravel, RA; 100:29-36Molecular Genetics and Metabolism10.1016/j.ymgme.2010.02.00501.5.2010
20383151Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.Kwiatkowski, N; Jelluma, N; Filippakopoulos, P; Soundararajan, M; Manak, MS; Kwon, M; Choi, HG; Sim, T; Deveraux, QL; Rottmann, S; Pellman, D; Shah, JV; Kops, GJPL; Knapp, S; Gray, NS; 6:359-368Nature Chemical Biology10.1038/nchembio.34501.5.2010
20435012Development of homogeneous luminescence assays for histone demethylase catalysis and binding.Kawamura, A; Tumber, A; Rose, NR; King, ONF; Daniel, M; Oppermann, U; Heightman, TD; Schofield, C; 404:86-93Analytical Biochemistry10.1016/j.ab.2010.04.0301.9.2010
20164216Generating a panel of highly specific antibodies to 20 human SH2 domains by phage displayPershad K, Pavlovic JD, Gräslund S, Nilsson P, Colwill K, Karatt-Vellatt A, Schofield DJ, Dyson MR, Pawson T, Kay BK, McCafferty J.(4):279-88Protein Eng Des Sel.10.1093/protein/gzq00304.23.2010
20400536New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights.López-Ramos, M; Prudent, R; Moucadel, V; Sautel, CF; Barette, C; Lafanechère, L; Mouawad, L; Grierson, D; Schmidt, F; Florent, J-C; Filippakopoulos, P; Bullock, AN; Knapp, S; Reiser, J-B; Cochet, C; 24:3171-3185FASEB Journal10.1096/fj.09-14374301.9.2010
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20083609Structure and function of a G-actin sequestering protein with a vital role in malaria oocyst development inside the mosquito vector.Hliscs M, Sattler JM, Tempel W, Artz JD, Dong A, Hui R, Matuschewski K, Schüler H285(15):11572-83J. Biol. Chem.10.1074/jbc.M109.05491609.04.2010
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20075161The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma.Xu GW, Ali M, Wood TE, Wong D, Maclean N, Wang X, Gronda M, Skrtic M, Li X, Hurren R, Mao X, Venkatesan M, Beheshti Zavareh R, Ketela T, Reed JC, Rose D, Moffat J, Batey RA, Dhe-Paganon S, Schimmer AD115(11):2251-9Blood10.1182/blood-2009-07-23119118.03.2010
20070948Four distinct structural domains in Clostridium difficile toxin B visualized using SAXS.Albesa-Jové, D; Bertrand, T; Carpenter, EP; Swain, GV; Lim, J; Zhang, J; Haire, LF; Vasisht, N; Braun, V; Lange, A; von Eichel-Streiber, C; Svergun, DI; Fairweather, NF; Brown, KA; 396:1260-1270Journal of Molecular Biology10.1016/j.jmb.2010.01.01212.3.2010
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20164216Generating a panel of highly specific antibodies to 20 human SH2 domains by phage display.Pershad K, Pavlovic JD, Gräslund S, Nilsson P, Colwill K, Karatt-Vellatt A, Schofield DJ, Dyson MR, Pawson T, Kay BK, McCafferty J23(4):279-88Protein Eng. Des. Sel.10.1093/protein/gzq00317.02.2010
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20017496Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.Boxer MB, Jiang JK, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ53(3):1048-55J. Med. Chem.10.1021/jm901577g11.02.2010
20030343Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins).Huber, K; Schemies, J; Uciechowska, U; Wagner, JM; Rumpf, T; Lewrick, F; Süss, R; Sippl, W; Jung, M; Bracher, F; 53:1383-1386Journal of Medicinal Chemistry10.1021/jm901055u01.2.2010
20150591Assessing the stability of membrane proteins to detect ligand binding using differential static light scattering.Senisterra GA, Ghanei H, Khutoreskaya G, Dobrovetsky E, Edwards AM, Privé GG, Vedadi M15(3):314-20J Biomol Screen10.1177/108705710935711711.02.2010
20124709A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation.Littler DR, Walker JR, Davis T, Wybenga-Groot LE, Finerty PJ, Newman E, Mackenzie F, Dhe-Paganon S66(Pt 2):143-51Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.10.1107/S174430910905254301.02.2010
Hyperpolarization-activated inward leakage currents caused by deletion or mutation of carboxy-terminal tyrosines of the Na+/K+-ATPase α subunitMeier, S; Tavraz, NN; Dürr, KL; Friedrich, T; 135:115-134Journal of General Physiology10.1085/jgp.20091030101.2.2010
19880352NK cell activation by KIR-binding antibody 1-7F9 and response to HIV-infected autologous cells in viremic and controller HIV-infected patientsJohansson SE, Hejdeman B, Hinkula J, Johansson MH, Romagne F, Wahren B, Wagtmann NR, Karre K, Berg L. 134(2):158-68Clin Immunol. 10.1016/j.clim.2009.10.00101.02.2010
20077426A non-enzymatic function of 17beta-hydroxysteroid dehydrogenase type 10 is required for mitochondrial integrity and cell survival.Rauschenberger, K; Schöler, K; Sass, JO; Sauer, S; Djuric, Z; Rumig, C; Wolf, NI; Okun, JG; Kölker, S; Schwarz, H; Fischer, C; Grziwa, B; Runz, H; Nümann, A; Shafqat, N; Kavanagh, KL; Hämmerling, G; Wanders, RJA; Shield, JPH; Wendel, U; Stern, D; Nawroth, P; Hoffmann, GF; Bartram, CR; Arnold, B; Bierhaus, A; Oppermann, U; Steinbeisser, H; Zschocke, J; 2:51-62EMBO Molecular Medicine10.1002/emmm.20090005501.2.2010
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20088513Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.Rose, NR; Woon, ECY; Kingham, GL; King, ONF; Mecinović, J; Clifton, IJ; Ng, SS; Talib-Hardy, J; Oppermann, U; McDonough, MA; Schofield, CJ; 53:1810-1818Journal of Medicinal Chemistry10.1021/jm901680b25.2.2010
20068161Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor.Harrison, H; Farnie, G; Howell, SJ; Rock, RE; Stylianou, S; Brennan, KR; Bundred, NJ; Clarke, RB; 70:709-718Cancer Research10.1158/0008-5472.CAN-09-168112.1.2010
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20084102Structural biology of human H3K9 methyltransferases.Wu H, Min J, Lunin VV, Antoshenko T, Dombrovski L, Zeng H, Allali-Hassani A, Campagna-Slater V, Vedadi M, Arrowsmith CH, Plotnikov AN, Schapira M5(1):e8570PLoS ONE10.1371/journal.pone.000857011.01.2010
20067792Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase.Yue, WW; Hozjan, V; Ge, W; Loenarz, C; Cooper, CDO; Schofield, CJ; Kavanagh, KL; Oppermann, U; McDonough, MA; 584:825-830FEBS Letters10.1016/j.febslet.2009.12.05519.2.2010
Large-scale structural analysis of protein tyrosine phosphatasesBarr, AJ; Knapp, S; 2:871-87610.1016/B978-0-12-374145-5.00107-81.12.2010
20525198Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.McCann, FE; Palfreeman, AC; Andrews, M; Perocheau, DP; Inglis, JJ; Schafer, P; Feldmann, M; Williams, RO; Brennan, FM; 12:R107-Arthritis Research10.1186/ar304101.01.2010
20668654Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.Rellos, P; Pike, ACW; Niesen, FH; Salah, E; Lee, WH; von Delft, F; Knapp, S; 8:e1000426-PLoS Biology10.1371/journal.pbio.100042627.7.2010
24260783Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity.Rai G,Kawamura A,Tumber A,Liang Y,Vogel JL,Arbuckle JH,Rose NR,Dexheimer TS,Foley TL,King ON,Quinn A,Mott BT,Schofield CJ,Oppermann U,Jadhav A,Simeonov A,Kristie TM,Maloney DJ.65Bookhttps://www.ncbi.nlm.nih.gov/books/NBK169450/01/01/2010
Differentiation therapy: targeting breast cancer stem cells to reduce resistance to radiotherapy and chemotherapy.Roy, R; Willan, PM; Clarke, R; Farnie, G; 12:O5-O5Breast Cancer Research10.1186/bcr249601.1.2010
20039431ANTI-CD3 therapy expands the numbers of CD4+ and CD8+ Treg cells and induces sustained amelioration of collagen-induced arthritis.Notley, CA; McCann, FE; Inglis, JJ; Williams, RO; 62:171-178Arthritis and Rheumatism10.1002/art.2505801.1.2010
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20094655A miniaturized screen for inhibitors of Jumonji histone demethylases.Sakurai, M; Rose, NR; Schultz, L; Quinn, AM; Jadhav, A; Ng, SS; Oppermann, U; Schofield, CJ; Simeonov, A; 6:357-364Molecular BioSystems10.1039/b912993f01.2.2010
20730082Structural comparison of human mammalian ste20-like kinases.Record, CJ; Chaikuad, A; Rellos, P; Das, S; Pike, ACW; Fedorov, O; Marsden, BD; Knapp, S; Lee, WH; 5:e11905-PLoS ONE10.1371/journal.pone.00119056.8.2010
21072165High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships.Niesen, FH; Schultz, L; Jadhav, A; Bhatia, C; Guo, K; Maloney, DJ; Pilka, ES; Wang, M; Oppermann, U; Heightman, TD; Simeonov, A; 5:e13719-PLoS ONE10.1371/journal.pone.00137192.11.2010
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21124847Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.King, ONF; Li, XS; Sakurai, M; Kawamura, A; Rose, NR; Ng, SS; Quinn, AM; Rai, G; Mott, BT; Beswick, P; Klose, RJ; Oppermann, U; Jadhav, A; Heightman, TD; Maloney, DJ; Schofield, CJ; Simeonov, A; 5:e15535-PLoS ONE10.1371/journal.pone.001553523.11.2010
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20008125Screening for inhibitors of low-affinity epigenetic peptide-protein interactions: an AlphaScreen-based assay for antagonists of methyl-lysine binding proteins.Wigle TJ, Herold JM, Senisterra GA, Vedadi M, Kireev DB, Arrowsmith CH, Frye SV, Janzen WP15(1):62-71J Biomol Screen10.1177/108705710935290211.12.2009
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19918066Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi.Chen C, Jin J, James DA, Adams-Cioaba MA, Park JG, Guo Y, Tenaglia E, Xu C, Gish G, Min J, Pawson T106(48):20336-41Proc. Natl. Acad. Sci. U.S.A.10.1073/pnas.091164010601.12.2009
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19702579A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity.Allali-Hassani A, Wasney GA, Chau I, Hong BS, Senisterra G, Loppnau P, Shi Z, Moult J, Edwards AM, Arrowsmith CH, Park HW, Schapira M, Vedadi M424(1):15-26Biochem. J.10.1042/BJ2009072315.11.2009
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19692350Investigating the genetic association between ERAP1 and ankylosing spondylitis.Harvey, D; Pointon, JJ; Evans, DM; Karaderi, T; Farrar, C; Appleton, LH; Sturrock, RD; Stone, MA; Oppermann, U; Brown, MA; Wordsworth, BP; 18:4204-4212Human Molecular Genetics10.1093/hmg/ddp3711.11.2009
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19694640Women with Pre-Eclampsia Have an Altered NKG2A and NKG2C Receptor Expression on Peripheral Blood Natural Killer CellsBachmayer N, Sohlberg E, Sundstrom Y, Hamad RR, Berg L, Bremme K, Sverremark-Ekstrom E. 62(3):147-57Am J Reprod Immuno10.1111/j.1600-0897.2009.00724.xSep. 2009
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19691130Crystallographic structure of the tetratricopeptide repeat domain of Plasmodium falciparum FKBP35 and its molecular interaction with Hsp90 C-terminal pentapeptide.Alag R, Bharatham N, Dong A, Hills T, Harikishore A, Widjaja AA, Shochat SG, Hui R, Yoon HS18(10):2115-24Protein Sci.10.1002/pro.22620.08.2009
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19678838Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases.Davis TL, Walker JR, Allali-Hassani A, Parker SA, Turk BE, Dhe-Paganon S276(16):4395-404FEBS J.10.1111/j.1742-4658.2009.07147.x01.08.2009
19553108Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors.Choi Y, Syeda F, Walker JR, Finerty PJ, Cuerrier D, Wojciechowski A, Liu Q, Dhe-Paganon S, Gray NS19(15):4467-70Bioorg. Med. Chem. Lett.10.1016/j.bmcl.2009.05.02901.08.2009
19360879Crystal structure of human carbonic anhydrase-related protein VIII reveals the basis for catalytic silencing.Picaud, SS; Muniz, JRC; Kramm, A; Pilka, ES; Kochan, G; Oppermann, U; Yue, WW; 76:507-511Proteins10.1002/prot.224111.8.2009
19520573Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors.Swarbrick, ME; Beswick, PJ; Gleave, RJ; Green, RH; Bingham, S; Bountra, C; Carter, MC; Chambers, LJ; Chessell, IP; Clayton, NM; Collins, SD; Corfield, JA; Hartley, CD; Kleanthous, S; Lambeth, PF; Lucas, FS; Mathews, N; Naylor, A; Page, LW; Payne, JJ; Pegg, NA; Price, HS; Skidmore, J; Stevens, AJ; Stocker, R; Stratton, SC; Stuart, AJ; Wiseman, JO; 19:4504-4508Bioorganic and Medicinal Chemistry Letters10.1016/j.bmcl.2009.02.0851.8.2009
19523822Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation approach.Beswick, PJ; Blackaby, AP; Bountra, C; Brown, T; Browning, K; Campbell, IB; Corfield, J; Gleave, RJ; Guntrip, SB; Hall, RM; Hindley, S; Lambeth, PF; Lucas, F; Mathews, N; Naylor, A; Player, H; Price, HS; Sidebottom, PJ; Taylor, NL; Webb, G; Wiseman, J; 19:4509-4514Bioorganic and Medicinal Chemistry Letters10.1016/j.bmcl.2009.02.0891.8.2009
E2P State Stabilization by the N-terminal Tail of the H,K-ATPase β-Subunit Is Critical for Efficient Proton Pumping underin VivoConditionsDürr, KL; Abe, K; Tavraz, NN; Friedrich, T; 284:20147-20154Journal of Biological Chemistry10.1074/jbc.m109.00576924.7.2009
19478087Structural determinants of G-protein α subunit selectivity by regulator of G-protein signaling 2 (RGS2)Kimple, AJ; Soundararajan, M; Hutsell, SQ; Roos, AK; Urban, DJ; Setola, V; Temple, BRS; Roth, BL; Knapp, S; Willard, FS; Siderovski, DP; 284:19402-19411Journal of Biological Chemistry10.1074/jbc.M109.02471117.7.2009
19585659Crystal structure of human diphosphoinositol phosphatase 1.Thorsell AG, Persson C, Gräslund S, Hammarström M, Busam RD, Hallberg BM77(1):242-6Proteins10.1002/prot.2248909.07.2009
19433323Substrate recognition and hydrolysis by a fungal xyloglucan-specific family 12 hydrolase.Powlowski J, Mahajan S, Schapira M, Master ER344(10):1175-9Carbohydr. Res.10.1016/j.carres.2009.04.02006.07.2009
19549604Structural basis for different specificities of acyltransferases associated with the human cytosolic and mitochondrial fatty acid synthases.Bunkoczi G,Misquitta S,Wu X,Lee WH,Rojkova A,Kochan G,Kavanagh KL,Oppermann U,Smith S. Chemistry & biologyhttp://dx.doi.org/10.1016/j.chembiol.2009.04.011 26/06/2009
19549604Structural basis for different specificities of acyltransferases associated with the human cytosolic and mitochondrial fatty acid synthases.Bunkoczi, G; Misquitta, S; Wu, X; Lee, WH; Rojkova, A; Kochan, G; Kavanagh, KL; Oppermann, U; Smith, S; 16:667-675Cell Chemistry Biology10.1016/j.chembiol.2009.04.01126.6.2009
19536100Open access chemical and clinical probes to support drug discovery.Edwards AM, Bountra C, Kerr DJ, Willson TM5(7):436-40Nat. Chem. Biol.10.1038/nchembio0709-43619.06.2009
19349281Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3.Porté, S; Valencia, E; Yakovtseva, EA; Borràs, E; Shafqat, N; Debreczeny, JE; Pike, ACW; Oppermann, U; Farrés, J; Fita, I; Parés, X; 284:17194-17205Journal of Biological Chemistry10.1074/jbc.M109.00180019.6.2009
19507244Crystal structures of human CDY proteins reveal a crotonase-like fold.Wu H, Min J, Antoshenko T, Plotnikov AN76(4):1054-61Proteins10.1002/prot.2247210.06.2009
19489729Large-scale structural biology of the human proteome.Edwards A78:541-68Annu. Rev. Biochem.10.1146/annurev.biochem.78.070907.10330506.06.2009
Evidence for the involvement of the threonine 201 side-chain in the interaction of nitrogen-containing bisphosphonates with farnesyl pyrophosphate synthaseKwassi, AAA; Pilka, ES; Evdokimov, A; Barnett, BL; Ebetino, FH; Russell, RGG; Kavanagh, KL; Oppermann, U; Dunford, JE; 44:S323-S323BONE10.1016/j.bone.2009.03.61101.6.2009
STUDYING THE ROLE OF PIM KINASES IN FLT3-ITD-INDUCED LEUKEMIA REVEALED PIM1 AS REGULATOR OF CXCL12/CXCR4-MEDIATED HOMING AND MIGRATIONBrault, L; Grundler, R; Gasser, C; Bullock, AN; Ehret, S; Spoo, A; Dierks, C; Biondi, A; Knapp, S; Duyster, J; Schwaller, J; 94:448-449Haematologica01.6.2009
19160016Targeting group II PAKs in cancer and metastasis.Eswaran, J; Soundararajan, M; Knapp, S; 28:209-217Cancer and Metastasis Reviews10.1007/s10555-008-9181-401.6.2009
19465561Forward genetics in Toxoplasma gondii reveals a family of rhoptry kinases that mediates pathogenesis.Sibley LD, Qiu W, Fentress S, Taylor SJ, Khan A, Hui R8(8):1085-93Eukaryotic Cell10.1128/EC.00107-0922.05.2009
19345228Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A.Kochan, G; Pilka, ES; von Delft, F; Oppermann, U; Yue, WW; 388:997-1008Journal of Molecular Biology10.1016/j.jmb.2009.03.06422.5.2009
19470714Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands.Crowther GJ, Napuli AJ, Thomas AP, Chung DJ, Kovzun KV, Leibly DJ, Castaneda LJ, Bhandari J, Damman CJ, Hui R, Hol WG, Buckner FS, Verlinde CL, Zhang Z, Fan E, van Voorhis WC14(6):700-7J Biomol Screen10.1177/108705710933574921.05.2009
19298070Crystal structure of the acid-induced arginine decarboxylase from Escherichia coli: reversible decamer assembly controls enzyme activity.Andréll, J; Hicks, MG; Palmer, T; Carpenter, EP; Iwata, S; Maher, MJ; 48:3915-3927Biochemistry10.1021/bi900075d12.5.2009
19508374Herpes Simplex Virus Infection Downmodulates NKG2D Ligand ExpressionSchepis D, D'Amato M, Studahl M, Bergstrom T, Karre K, Berg L. 69(5):429-36Scand J Immunol10.1111/j.1365-3083.2009.02241.x2009 May
19425169Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferationHuck, K; Feyen, O; Niehues, T; Rüschendorf, F; Hübner, N; Laws, HJ; Telieps, T; Knapp, S; Wacker, HH; Meindl, A; Jumaa, H; Borkhardt, A; 119:1350-1358Journal of Clinical Investigation10.1172/JCI379011.5.2009
Missense mutation in the inducible T-cell kinase (ITK) leading to immunodeficiency and fatal immune dysregulation after EBV infectionTelieps, T; Huck, K; Feyen, O; Niehues, T; Rueschendorf, F; Huebner, N; Laws, HJ; Knapp, S; Wacker, HH; Meindl, A; Jumaa, H; Borkhardt, A; 221:209-209Klinische Pädiatrie01.01.2009
19236052Specificity of Campylobacter jejuni adhesin PEB3 for phosphates and structural differences among its ligand complexes.Min T, Vedadi M, Watson DC, Wasney GA, Munger C, Cygler M, Matte A, Young NM48(14):3057-67Biochemistry10.1021/bi802195d14.04.2009
19197235Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondii.Qiu W, Wernimont A, Tang K, Taylor S, Lunin V, Schapira M, Fentress S, Hui R, Sibley LD28(7):969-79EMBO J.10.1038/emboj.2009.2408.04.2009
19352432In situ proteolysis to generate crystals for structure determination: an update.Wernimont A, Edwards A4(4):e5094PLoS ONE10.1371/journal.pone.000509407.04.2009
REFINING THE GENETIC ASSOCIATION BETWEEN ANKYLOSING SPODYLITIS AND ERAP1Harvey, D; Pointon, JJ; Farrar, C; Appleton, LA; Oppermann, U; Brown, MA; Wordsworth, BP; 48:I52-I52Rheumatology01.4.2009
19309729Structure of dystrophia myotonica protein kinase.Elkins, JM; Amos, A; Niesen, FH; Pike, ACW; Fedorov, O; Knapp, S; 18:782-791Protein Science10.1002/pro.8201.4.2009
18984029Short-term glucocorticoid treatment increases insulin secretion in islets derived from lean mice through multiple pathways and mechanisms.Hult, M; Ortsäter, H; Schuster, G; Graedler, F; Beckers, J; Adamski, J; Ploner, A; Jörnvall, H; Bergsten, P; Oppermann, U; 301:109-116Molecular and Cellular Endocrinology10.1016/j.mce.2008.09.03825.3.2009
19013211Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4.Lee, WH; Lukacik, P; Guo, K; Ugochukwu, E; Kavanagh, KL; Marsden, B; Oppermann, U; 301:199-204Molecular and Cellular Endocrinology10.1016/j.mce.2008.09.04225.3.2009
19303852Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation.Rahighi S, Ikeda F, Kawasaki M, Akutsu M, Suzuki N, Kato R, Kensche T, Uejima T, Bloor S, Komander D, Randow F, Wakatsuki S, Dikic I.136(6):1098-109Cell10.1016/j.cell.2009.03.00720.03.2009
19237555The structure of CDK4/cyclin D3 has implications for models of CDK activation.Takaki, T; Echalier, A; Brown, NR; Hunt, T; Endicott, JA; Noble, MEM; 106:4171-4176Proceedings of the National Academy of Sciences10.1073/pnas.080967410601.3.2009
19061875Analysis of the substrate-binding site of human carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.El-Hawari, Y; Favia, AD; Pilka, ES; Kisiela, M; Oppermann, U; Martin, H-J; Maser, E; 178:234-241Chemico-Biological Interactions10.1016/j.cbi.2008.11.00416.3.2009
19027726The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative.Persson, B; Kallberg, Y; Bray, JE; Bruford, E; Dellaporta, SL; Favia, AD; Duarte, RG; Jörnvall, H; Kavanagh, KL; Kedishvili, N; Kisiela, M; Maser, E; Mindnich, R; Orchard, S; Penning, TM; Thornton, JM; Adamski, J; Oppermann, U; 178:94-98Chemico-Biological Interactions10.1016/j.cbi.2008.10.04016.3.2009
19061874The human short-chain dehydrogenase/reductase (SDR) superfamily: a bioinformatics summary.Bray, JE; Marsden, BD; Oppermann, U; 178:99-109Chemico-Biological Interactions10.1016/j.cbi.2008.10.05816.3.2009
19280598Crystal structure of human eIF5A1: insight into functional similarity of human eIF5A1 and eIF5A2.Tong Y, Park I, Hong BS, Nedyalkova L, Tempel W, Park HW75(4):1040-5Proteins10.1002/prot.2237813.03.2009
19278650Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation.Bullock, AN; Das, S; Debreczeni, JE; Rellos, P; Fedorov, O; Niesen, FH; Guo, K; Papagrigoriou, E; Amos, AL; Cho, S; Turk, BE; Ghosh, G; Knapp, S; 17:352-362Structure10.1016/j.str.2008.12.02301.3.2009
19146410Discovery of indoline-based, natural-product-like compounds as probes of focal adhesion kinase signaling pathways.Poondra RR, Kumar NN, Bijian K, Prakesch M, Campagna-Slater V, Reayi A, Reddy PT, Choudhry A, Barnes ML, Leek DM, Daroszewska M, Lougheed C, Xu B, Schapira M, Alaoui-Jamali MA, Arya P11(2):303-9J Comb Chem10.1021/cc800152509.03.2009
19372756Impaired plasma membrane targeting or protein stability by certain ATP1A2 mutations identified in sporadic or familial hemiplegic migraineNeslihan N. Tavraz, Katharina L. Dürr, Jan B. Koenderink, Tobias Freilinger, Ernst Bamberg, Martin Dichgans and Thomas Friedrich1, 82-87 Channels Landes Bioscience 03.03.2009
18954305Structural basis and specificity of human otubain 1-mediated deubiquitination.Edelmann MJ, Iphöfer A, Akutsu M, Altun M, di Gleria K, Kramer HB, Fiebiger E, Dhe-Paganon S, Kessler BM418(2):379-90Biochem. J.10.1042/BJ2008131801.03.2009
19252972Resistance to endocrine therapy: are breast cancer stem cells the culprits?O'Brien, CS; Howell, SJ; Farnie, G; Clarke, RB; 14:45-54Journal of Mammary Gland Biology and Neoplasia10.1007/s10911-009-9115-y01.3.2009
Identification of a novel primary immunodeficiency syndrome leading to an XLP-like phenotype in girlsHuck, K; Feyen, O; Rueschendorf, F; Knapp, S; Borkhardt, A; 168:380-380European Journal of Pediatrics01.3.2009
19234526Structure and function of histone methylation binding proteins.Adams-Cioaba MA, Min J87(1):93-105Biochem. Cell Biol.10.1139/O08-12924.02.2009
19243223The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta.Pardee KI, Xu X, Reinking J, Schuetz A, Dong A, Liu S, Zhang R, Tiefenbach J, Lajoie G, Plotnikov AN, Botchkarev A, Krause HM, Edwards A7(2):e43PLoS Biol.10.1371/journal.pbio.100004324.02.2009
19233876Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2.Guo Y, Nady N, Qi C, Allali-Hassani A, Zhu H, Pan P, Adams-Cioaba MA, Amaya MF, Dong A, Vedadi M, Schapira M, Read RJ, Arrowsmith CH, Min J37(7):2204-10Nucleic Acids Res.10.1093/nar/gkp08620.02.2009
19089949An intact SAM-dependent methyltransferase fold is encoded by the human endothelin-converting enzyme-2 gene.Tempel W, Wu H, Dombrovsky L, Zeng H, Loppnau P, Zhu H, Plotnikov AN, Bochkarev A74(3):789-93Proteins10.1002/prot.2229915.02.2009
19201907 Herpesvirus Seropositivity in Childhood Associates with Decreased Monocyte-Induced NK Cell IFN-gamma ProductionSaghafian-Hedengren S, Sundstrom Y, Sohlberg E, Nilsson C, Linde A, Troye-Blomberg M, Berg L, Sverremark-Ekstrom E. 182(4):2511-7J Immunol10.4049/jimmunol.080169915 Feb 2009
Functional Significance of E2State Stabilization by Specific α/β-Subunit Interactions of Na,K- and H,K-ATPaseDürr, KL; Tavraz, NN; Dempski, RE; Bamberg, E; Friedrich, T; 284:3842-3854Journal of Biological Chemistry10.1074/jbc.m8081012006.2.2009
18923809Dynamic protein methylation in chromatin biology.Ng, SS; Yue, WW; Oppermann, U; Klose, RJ; 66:407-422Cellular and Molecular Life Sciences10.1007/s00018-008-8303-z01.2.2009
19215300Distinguishing between calpain heterodimerization and homodimerization.Ravulapalli R, Campbell RL, Gauthier SY, Dhe-Paganon S, Davies PL276(4):973-82FEBS J.10.1111/j.1742-4658.2008.06833.x01.02.2009
19097784Discovery of thiophene inhibitors of polo-like kinaseEmmitte, K.A.: Andrews, C.W.; Badiang, J.G.; Davis-Ward, R.G.; Dickson, H.D.; Drewry, D.H.; Emerson, H.K.; Epperly, A.H.; Hassler, D.F.; Knick, V.B.; Kuntz, K.W.; Lansing, T.J.; Linn, J.A.; Mook, R.A. Jr.; Nailor, K.E.; Salovich, J.M.; Spehar, G.M.; Cheung, M. 1018-1021Bioorg. Med. Chem. Lett.10.1016/j.bmcl.2008.11.04102.01.2009
19151156Structure of the human RECQ1 helicase reveals a putative strand-separation pin.Pike, ACW; Shrestha, B; Popuri, V; Burgess-Brown, N; Muzzolini, L; Costantini, S; Vindigni, A; Gileadi, O; 106:1039-1044Proceedings of the National Academy of Sciences10.1073/pnas.080690810627.1.2009
19167335Large-scale structural analysis of the classical human protein tyrosine phosphatome.Barr, AJ; Ugochukwu, E; Lee, WH; King, ONF; Filippakopoulos, P; Alfano, I; Savitsky, P; Burgess-Brown, NA; Müller, S; Knapp, S; 136:352-363Cell10.1016/j.cell.2008.11.03823.1.2009
19097799Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone.Zimmermann, TJ; Niesen, FH; Pilka, ES; Knapp, S; Oppermann, U; Maier, ME; 17:530-536Bioorganic and Medicinal Chemistry10.1016/j.bmc.2008.11.07615.1.2009
19141289Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding SiteScheeff, ED; Eswaran, J; Bunkoczi, G; Knapp, S; Manning, G; 17:128-138Structure10.1016/j.str.2008.10.01814.1.2009
19841676A new method for publishing three-dimensional contentRaush, E; Totrov, M; Marsden, BD; Abagyan, R; 4:-PLoS ONE10.1371/journal.pone.000739420.10.2009
18564343Increased proportion of CD56(bright) natural killer cells in active and inactive systemic lupus erythematosusSchepis D, Gunnarsson I, Eloranta ML, Lampa J, Jacobson SH, Karre K, Berg L126(1):140-6Immunology10.1111/j.1365-2567.2008.02887.x2009 Jan.
19847312SGC--structural biology and human health: a new approach to publishing structural biology results.Lee, WH; Atienza-Herrero, J; Abagyan, R; Marsden, BD; 4:e7675-PLoS ONE10.1371/journal.pone.000767520.10.2009
19394220Potent and selective α1A adrenoceptor partial agonists—Novel imidazole frameworksWhitlock, GA; Brennan, PE; Roberts, LR; Stobie, A; 19:3118 - 3121-3118 - 3121Bioorganic and Medicinal Chemistry Letters10.1016/j.bmcl.2009.03.16201.01.2009
19340315HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domainGingras, MC; Zhang, YL; Kharitidi, D; Barr, AJ; Knapp, S; Tremblay, ML; Pause, A; 4:-PLoS ONE10.1371/journal.pone.00051052.4.2009
Discovery of a novel azepine series of potent and selective 5-HT2C agonists as potential treatments for urinary incontinenceBrennan, PE; Whitlock, GA; Ho, DKH; Conlon, K; McMurray, G; 19:4999 - 5003-4999 - 5003Bioorganic and Medicinal Chemistry Letters10.1016/j.bmcl.2009.07.06301.01.2009
19330033Novel mutations in ACVR1 result in atypical features in two fibrodysplasia ossificans progressiva patients.Petrie, KA; Lee, WH; Bullock, AN; Pointon, JJ; Smith, R; Russell, RGG; Brown, MA; Wordsworth, BP; Triffitt, JT; 4:e5005-PLoS ONE10.1371/journal.pone.000500501.01.2009
Are stem-like cells responsible for resistance to therapy in breast cancer?O'Brien, CS; Farnie, G; Howell, SJ; Clarke, RB; :97-10910.1007/978-1-4020-8526-0_61.1.2009
19841674Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor.Bullock, AN; Russo, S; Amos, A; Pagano, N; Bregman, H; Debreczeni, JE; Lee, WH; von Delft, F; Meggers, E; Knapp, S; 4:e7112-PLoS ONE10.1371/journal.pone.000711220.10.2009
Erratum: Tic32, an essential component in chloroplast biogenesis (Journal of Biological Chemistry (2004) vol. 279 (34756-34762))Hörmann, F; Küchler, M; Sveshnikov, D; Oppermann, U; Li, Y; Soll, J; 284:29240-Journal of Biological Chemistry10.1074/jbc.A40281720016.10.2009
19841672Structural basis for substrate specificity in human monomeric carbonyl reductases.Pilka, ES; Niesen, FH; Lee, WH; El-Hawari, Y; Dunford, JE; Kochan, G; Wsol, V; Martin, H-J; Maser, E; Oppermann, U; 4:e7113-PLoS ONE10.1371/journal.pone.000711320.10.2009
Erratum: Extremely tight binding of a ruthenium complex to glycogen synthase kinase 3 (ChemBioChem (2008) vol. 9 (2933-2936))Atilla-Gokcumen, GE; Pagano, N; Streu, C; Maksimoska, J; Filippakopoulos, P; Knapp, S; Meggers, E; 10:198-ChemBioChem10.1002/cbic.20080048926.1.2009
19204960Total synthesis of rapamycin.Ley, SV; Tackett, MN; Maddess, ML; Anderson, JC; Brennan, PE; Cappi, MW; Heer, JP; Helgen, C; Kori, M; Kouklovsky, C; Marsden, SP; Norman, J; Osborn, DP; Palomero, MA; Pavey, JBJ; Pinel, C; Robinson, LA; Schnaubelt, J; Scott, JS; Spilling, CD; Watanabe, H; Wesson, KE; Willis, MC; 15:2874-2914Chemistry - A European Journal10.1002/chem.20080165601.01.2009
18930738A D-pathway mutation decouples the Paracoccus denitrificans cytochrome c oxidase by altering the side-chain orientation of a distant conserved glutamate.Dürr, KL; Koepke, J; Hellwig, P; Müller, H; Angerer, H; Peng, G; Olkhova, E; Richter, O-MH; Ludwig, B; Michel, H; 384:865-877Journal of Molecular Biology10.1016/j.jmb.2008.09.07401.12.2008
19035792Assessment of Chemical Coverage of Kinome Space and its Implications for Kinase Drug DiscoveryBamborough, P.; Drewry, D.; Harper, G.; Smith, G.K.; Schneider, K.7898-7914J. Med. Chem.10.1021/jm801103612.25.2008
19101474Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis.Artz JD, Dunford JE, Arrowood MJ, Dong A, Chruszcz M, Kavanagh KL, Minor W, Russell RG, Ebetino FH, Oppermann U, Hui R15(12):1296-306Chem. Biol.10.1016/j.chembiol.2008.10.01722.12.2008
19035373Extremely tight binding of a ruthenium complex to glycogen synthase kinase 3.Atilla-Gokcumen, GE; Pagano, N; Streu, C; Maksimoska, J; Filippakopoulos, P; Knapp, S; Meggers, E; 9:2933-2936ChemBioChem10.1002/cbic.20080048915.12.2008
19043414Molecular basis of Pirh2-mediated p53 ubiquitylationSheng Y, Laister RC, Lemak A, Wu B, Tai E, Duan S, Lukin J, Sunnerhagen M, Srisailam S, Karra M, Benchimol S, Arrowsmith CH15(12):1334-42Nat Struct Mol Biol.10.1038/nsmb.152112.2008
19053525Kinase-Targeted Library Design through the Application of the PharmPrint MethodologyDeanda, F.; Stewart, E.L.; Reno, M.J.; Drewry, D.H. 2395-2403J. Chem Inf. and Model.10.1021/ci800276t12.2008
19011750Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes.Kavanagh, KL; Jörnvall, H; Persson, B; Oppermann, U; 65:3895-3906Cellular and Molecular Life Sciences10.1007/s00018-008-8588-y01.12.2008
19023694Insights into outer membrane protein crystallization.Newstead, S; Hobbs, J; Jordan, D; Carpenter, EP; Iwata, S; 25:631-638Molecular Membrane Biology10.1080/0968768080252657401.12.2008
18942826Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.Rose, NR; Ng, SS; Mecinović, J; Liénard, BMR; Bello, SH; Sun, Z; McDonough, MA; Oppermann, U; Schofield, CJ; 51:7053-7056Journal of Medicinal Chemistry10.1021/jm800936s27.11.2008
Dissecting Proto-Oncogenic PIM Serine/Threonine Kinases in FLT3-ITD-Induced Leukemogenesis: PIM1 Regulates CXCL12/CXCR4-Mediated Homing and MigrationGasser, C; Grundler, R; Brault, L; Bullock, A; Dechow, T; Nawijn, M; Woetzel, S; Ehret, S; Berridge, G; Spoo, A; Dierks, C; Biondi, A; Knapp, S; Duyster, J; Schwaller, J; 112:1299-1299Blood16.11.2008
Diverse Functional Consequences of Mutations in the Na+/K+-ATPase α2-Subunit Causing Familial Hemiplegic Migraine Type 2Tavraz, NN; Friedrich, T; Dürr, KL; Koenderink, JB; Bamberg, E; Freilinger, T; Dichgans, M; 283:31097-31106Journal of Biological Chemistry10.1074/jbc.m8027712007.11.2008
19028587Structural insights into the inhibited states of the Mer receptor tyrosine kinase.Huang X, Finerty P, Walker JR, Butler-Cole C, Vedadi M, Schapira M, Parker SA, Turk BE, Thompson DA, Dhe-Paganon S165(2):88-96J. Struct. Biol.10.1016/j.jsb.2008.10.00305.11.2008
18835181Building skeletally diverse architectures on the Indoline Scaffold: the discovery of a chemical probe of focal adhesion kinase signaling networks.Prakesch M, Bijian K, Campagna-Slater V, Quevillon S, Joseph R, Wei CQ, Sesmilo E, Reayi A, Poondra RR, Barnes ML, Leek DM, Xu B, Lougheed C, Schapira M, Alaoui-Jamali M, Arya P16(21):9596-602Bioorg. Med. Chem.10.1016/j.bmc.2008.09.02501.11.2008
18927357Structure and molecular mechanism of a nucleobase-cation-symport-1 family transporter.Weyand, S; Shimamura, T; Yajima, S; Suzuki, S; Mirza, O; Krusong, K; Carpenter, EP; Rutherford, NG; Hadden, JM; O'Reilly, J; Ma, P; Saidijam, M; Patching, SG; Hope, RJ; Norbertczak, HT; Roach, PCJ; Iwata, S; Henderson, PJF; Cameron, AD; 322:709-713Science10.1126/science.116444031.10.2008
18936235Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells.Notley, CA; Inglis, JJ; Alzabin, S; McCann, FE; McNamee, KE; Williams, RO; 205:2491-2497Journal of Experimental Medicine10.1084/jem.2007270720.10.2008
18601654Structural and kinetic differences between human and Aspergillus fumigatus D-glucosamine-6-phosphate N-acetyltransferase.Hurtado-Guerrero R, Raimi OG, Min J, Zeng H, Vallius L, Shepherd S, Ibrahim AF, Wu H, Plotnikov AN, van Aalten DM415(2):217-23Biochem. J.10.1042/BJ2008100015.10.2008
18772889Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1.Avvakumov GV, Walker JR, Xue S, Li Y, Duan S, Bronner C, Arrowsmith CH, Dhe-Paganon S455(7214):822-5Nature10.1038/nature0727309.10.2008
18574471CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases.Bettayeb, K; Oumata, N; Echalier, A; Ferandin, Y; Endicott, JA; Galons, H; Meijer, L; 27:5797-5807Oncogene10.1038/onc.2008.19101.10.2008
18825127A pilot project to generate affinity reagents to human proteins.Uhlen M, Gräslund S, Sundström M5(10):854-5Nat. Methods10.1038/nmeth1008-85401.10.2008
18674618Overcoming the challenges of membrane protein crystallography.Carpenter, EP; Beis, K; Cameron, AD; Iwata, S; 18:581-586Current Opinion in Structural Biology10.1016/j.sbi.2008.07.00101.10.2008
18692962Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons.Anand, U; Otto, WR; Sanchez-Herrera, D; Facer, P; Yiangou, Y; Korchev, Y; Birch, R; Benham, C; Bountra, C; Chessell, IP; Anand, P; 138:667-680PAIN10.1016/j.pain.2008.06.00715.9.2008
18702514Structure of human pancreatic lipase-related protein 2 with the lid in an open conformation.Eydoux C, Spinelli S, Davis TL, Walker JR, Seitova A, Dhe-Paganon S, De Caro A, Cambillau C, Carrière F47(36):9553-64Biochemistry10.1021/bi800557609.09.2008
18775312Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation.Filippakopoulos, P; Kofler, M; Hantschel, O; Gish, GD; Grebien, F; Salah, E; Neudecker, P; Kay, LE; Turk, BE; Superti-Furga, G; Pawson, T; Knapp, S; 134:793-803Cell10.1016/j.cell.2008.07.0475.9.2008
18767156The crystal structure of human cleavage and polyadenylation specific factor-5 reveals a dimeric Nudix protein with a conserved catalytic site.Trésaugues L, Stenmark P, Schüler H, Flodin S, Welin M, Nyman T, Hammarström M, Moche M, Gräslund S, Nordlund P73(4):1047-52Proteins10.1002/prot.2219804.09.2008
18765831Linear Motif Atlas for Phosphorylation-Dependent SignalingMiller, ML; Jensen, LJ; Diella, F; Jorgensen, C; Tinti, M; Li, L; Hsiung, M; Parker, SA; Bordeaux, J; Sicheritz-Ponten, T; Olhovsky, M; Pasculescu, A; Alexander, J; Knapp, S; Blom, N; Bork, P; Li, S; Cesareni, G; Pawson, T; Turk, BE; Yaffe, MB; Brunak, S; Linding, R; 1:-Science Signaling10.1126/scisignal.11594332.9.2008
18790752N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine.Bettayeb, K; Sallam, H; Ferandin, Y; Popowycz, F; Fournet, G; Hassan, M; Echalier, A; Bernard, P; Endicott, J; Joseph, B; Meijer, L; 7:2713-2724Molecular Cancer Therapeutics10.1158/1535-7163.mct-08-008001.9.2008
The Role of Active Site Threonine 201 in the Inhibition of Farnesyl Pyrophosphate Synthase by Nitrogen Containing BisphosphonatesDunford, JE; Pilka, E; Kwaasi, A; Evdokimov, A; Barnett, BL; Oppermann, U; Ebetino, FH; Russell, RGG; Kavanagh, KL; 23:S122-S122Journal of Bone and Mineral Research01.9.2008
CARB 4-Elucidating the mechanism of human UDP-glucose dehydrogenase using kinetic, mutational and structural studiesEgger, S; Guo, K; Kavanagh, KL; Oppermann, U; Klimacek, M; Nidetzky, B; 236:-ACS National Meeting Book of Abstracts17.8.2008
18599315Volunteer studies in pain research--opportunities and challenges to replace animal experiments: the report and recommendations of a Focus on Alternatives workshop.Langley, CK; Aziz, Q; Bountra, C; Gordon, N; Hawkins, P; Jones, A; Langley, G; Nurmikko, T; Tracey, I; 42:467-473NeuroImage10.1016/j.neuroimage.2008.05.03015.8.2008
18713141Leishmania surface protein gp63 binds directly to human natural killer cells and inhibits proliferationLieke T, Nylen S, Eidsmo L, McMaster WR, Mohammadi AM, Khamesipour A, Berg L, Akuffo H. 153(2):221-30Clin Exp Immunol.10.1111/j.1365-2249.2008.03687.x2008 Aug.
18639460UnPAKing the class differences among p21-activated kinases.Eswaran, J; Soundararajan, M; Kumar, R; Knapp, S; 33:394-403Trends in Biochemical Sciences10.1016/j.tibs.2008.06.00201.8.2008
18414789Cytosine arabinoside affects the heat and capsaicin receptor TRPV1 localisation and sensitivity in human sensory neurons.Anand, U; Otto, WR; Bountra, C; Chessell, I; Sinisi, M; Birch, R; Anand, P; 89:1-7Journal of Neuro-Oncology10.1007/s11060-008-9585-601.8.2008
18635947FKBP family proteins: immunophilins with versatile biological functions.Kang CB, Hong Y, Dhe-Paganon S, Yoon HS16(4):318-25Neurosignals10.1159/00012304118.07.2008
18618707The structure of the PP2A regulatory subunit B56 gamma: the remaining piece of the PP2A jigsaw puzzle.Magnusdottir A, Stenmark P, Flodin S, Nyman T, Kotenyova T, Gräslund S, Ogg D, Nordlund P74(1):212-21Proteins10.1002/prot.2215012.07.2008
18566585The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.Baumli, S; Lolli, G; Lowe, ED; Troiani, S; Rusconi, L; Bullock, AN; Debreczeni, JE; Knapp, S; Johnson, LN; 27:1907-1918EMBO Journal10.1038/emboj.2008.1219.7.2008
18393397RhoB can adopt a Mg2+ free conformation prior to GEF binding.Soundararajan, M; Turnbull, A; Fedorov, O; Johansson, C; Doyle, DA; 72:498-505Proteins10.1002/prot.2201701.7.2008
18511070Structural analysis of CYP2R1 in complex with vitamin D3.Strushkevich N, Usanov SA, Plotnikov AN, Jones G, Park HW380(1):95-106J. Mol. Biol.10.1016/j.jmb.2008.03.06527.06.2008
18542887High throughput crystallography at SGC Toronto: an overview.Bochkarev A, Tempel W426:515-21Methods Mol. Biol.10.1007/978-1-60327-058-8_3411.06.2008
18367445Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism.Wu H, Min J, Zeng H, McCloskey DE, Ikeguchi Y, Loppnau P, Michael AJ, Pegg AE, Plotnikov AN283(23):16135-46J. Biol. Chem.10.1074/jbc.M71032320006.06.2008
18455736Thioredoxin A active-site mutants form mixed disulfide dimers that resemble enzyme-substrate reaction intermediates.Kouwen, TRHM; Andréll, J; Schrijver, R; Dubois, J-YF; Maher, MJ; Iwata, S; Carpenter, EP; van Dijl, JM; 379:520-534Journal of Molecular Biology10.1016/j.jmb.2008.03.0776.6.2008
18538573A SPOT on the chromatin landscape? Histone peptide arrays as a tool for epigenetic research.Nady N, Min J, Kareta MS, Chédin F, Arrowsmith CH33(7):305-13Trends Biochem. Sci.10.1016/j.tibs.2008.04.01404.06.2008
18547520Autoregulation by the juxtamembrane region of the human ephrin receptor tyrosine kinase A3 (EphA3).Davis TL, Walker JR, Loppnau P, Butler-Cole C, Allali-Hassani A, Dhe-Paganon S16(6):873-84Structure10.1016/j.str.2008.03.00801.06.2008
18364358Structural and biophysical characterization of human myo-inositol oxygenase.Thorsell AG, Persson C, Voevodskaya N, Busam RD, Hammarström M, Gräslund S, Gräslund A, Hallberg BM283(22):15209-16J. Biol. Chem.10.1074/jbc.M80034820030.05.2008
18397323The crystal structure of human WD40 repeat-containing peptidylprolyl isomerase (PPWD1).Davis TL, Walker JR, Ouyang H, MacKenzie F, Butler-Cole C, Newman EM, Eisenmesser EZ, Dhe-Paganon S275(9):2283-95FEBS J.10.1111/j.1742-4658.2008.06381.x01.05.2008
18289875Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study.Burgess-Brown, NA; Sharma, S; Sobott, F; Loenarz, C; Oppermann, U; Gileadi, O; 59:94-102Protein Expression and Purification10.1016/j.pep.2008.01.00801.5.2008
18448703Application of high-throughput isothermal denaturation to assess protein stability and screen for ligands.Senisterra GA, Soo Hong B, Park HW, Vedadi M13(5):337-42J Biomol Screen10.1177/108705710831782530.04.2008
18434541Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.Soundararajan, M; Willard, FS; Kimple, AJ; Turnbull, AP; Ball, LJ; Schoch, GA; Gileadi, C; Fedorov, OY; Dowler, EF; Higman, VA; Hutsell, SQ; Sundström, M; Doyle, DA; Siderovski, DP; 105:6457-6462Proceedings of the National Academy of Sciences10.1073/pnas.080150810523.4.2008
18285338Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.Schuetz A, Min J, Allali-Hassani A, Schapira M, Shuen M, Loppnau P, Mazitschek R, Kwiatkowski NP, Lewis TA, Maglathin RL, McLean TH, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH283(17):11355-63J. Biol. Chem.10.1074/jbc.M70736220025.04.2008
18412263Crystal structure of the methyltransferase domain of human TARBP1.Wu H, Min J, Zeng H, Plotnikov AN72(1):519-25Proteins10.1002/prot.2206517.04.2008
18327899Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.Dunford, JE; Kwaasi, AA; Rogers, MJ; Barnett, BL; Ebetino, FH; Russell, RGG; Oppermann, U; Kavanagh, KL; 51:2187-2195Journal of Medicinal Chemistry10.1021/jm701573310.4.2008
Characterization of Na,K-ATPase and H,K-ATPase Enzymes with Glycosylation-Deficient β-Subunit Variants by Voltage-Clamp Fluorometry inXenopusOocytes†Dürr, KL; Tavraz, NN; Zimmermann, D; Bamberg, E; Friedrich, T; 47:4288-4297Biochemistry10.1021/bi800092k01.4.2008
17897851The effects of ibuprofen and the neurokinin-1 receptor antagonist GR205171A on Fos expression in the ferret trigeminal nucleus following tooth pulp stimulation.Worsley, MA; Clayton, NM; Bountra, C; Boissonade, FM; 12:385-394European Journal of Pain10.1016/j.ejpain.2007.07.01001.4.2008
Crystal structures of the acyl transferases involved in the human cytosolic and mitochondrial fatty acid synthaseMisquitta, SA; Bunkoczi, G; Wu, X; Kavanagh, KL; Hozjan, V; Oppermann, U; Smith, S; 22:-FASEB Journal01.4.2008
18036338Role of short-chain hydroxyacyl CoA dehydrogenases in SCHAD deficiency.Filling, C; Keller, B; Hirschberg, D; Marschall, H-U; Jörnvall, H; Bennett, MJ; Oppermann, U; 368:6-11Biochemical and Biophysical Research Communications10.1016/j.bbrc.2007.10.18828.3.2008
18282486Structural genomics and drug discovery: all in the family.Weigelt J, McBroom-Cerajewski LD, Schapira M, Zhao Y, Arrowsmith CH, Arrowmsmith CH12(1):32-9Curr Opin Chem Biol10.1016/j.cbpa.2008.01.04507.03.2008
Characterization of the human carbonyl reductase 3 (CBR3) by site-directed mutagenesisEl-Hawari, Y; Pilka, E; Martin, H-J; Oppermann, U; Maser, E; 377:67-67Naunyn-Schmiedeberg's Archives of Pharmacology01.3.2008
Structure activity relationships of nitrogen containing bisphosphonates which induce conformational changes in farnesyl pyrophosphate synthaseDunford, JE; Kwaasi, AA; Kavanagh, KL; Rogers, MJ; Oppermann, U; Barnett, BB; Ebetino, FH; Graham, R; Russell, G; 42:S71-S71BONE10.1016/j.bone.2007.12.12901.3.2008
The interaction of sidechain nitrogen with active site threonine is not essential for inhibition of farnesyl pyrophosphate synthase by nitrogen containing bisphosphonatesDunford, JE; Pilka, E; Kwaasi, AA; Evdokimov, A; Barnett, BL; Oppermann, U; Ebetino, FH; Graham, R; Russell, G; Kavanagh, KL; 42:S70-S71BONE10.1016/j.bone.2007.12.12801.3.2008
18232649Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin complex.Echalier, A; Bettayeb, K; Ferandin, Y; Lozach, O; Clément, M; Valette, A; Liger, F; Marquet, B; Morris, JC; Endicott, JA; Joseph, B; Meijer, L; 51:737-751Journal of Medicinal Chemistry10.1021/jm700940h01.2.2008
18239682Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites.Pike, ACW; Rellos, P; Niesen, FH; Turnbull, A; Oliver, AW; Parker, SA; Turk, BE; Pearl, LH; Knapp, S; 27:704-714EMBO Journal10.1038/emboj.2008.820.2.2008
18217775Redox-linked structural changes associated with the formation of a catalytically competent form of the diheme cytochrome c peroxidase from Pseudomonas aeruginosa.Echalier, A; Brittain, T; Wright, J; Boycheva, S; Mortuza, GB; Fülöp, V; Watmough, NJ; 47:1947-1956Biochemistry10.1021/bi702064f01.2.2008
18250626Bermuda Principles meet structural biology.Edwards A15(2):116Nat. Struct. Mol. Biol.10.1038/nsmb0208-11606.02.2008
18267130Doing more than just the structure-structural genomics in kinase drug discovery.Marsden, BD; Knapp, S; 12:40-45Current Opinion in Chemical Biology10.1016/j.cbpa.2008.01.04201.2.2008
17627773Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus-1 infectionTitanji K, Sammicheli S, De Milito A, Mantegani P, Fortis C, Berg L, Karre K, Travi G, Tassandin C, Lopalco L, Rethi B, Tambussi G, Chiodi F. 123(2):164-70Immunolog10.1111/j.1365-2567.2007.02657.x2008 Feb.
18275814Structures of P. falciparum protein kinase 7 identify an activation motif and leads for inhibitor design.Merckx, A; Echalier, A; Langford, K; Sicard, A; Langsley, G; Joore, J; Doerig, C; Noble, M; Endicott, J; 16:228-238Structure10.1016/j.str.2007.11.01401.2.2008
18282129Ligand supplementation as a method to increase soluble heterologous protein production.Hozjan, V; Guo, K; Wu, X; Oppermann, U; 5:137-143Expert Review of Proteomics10.1586/14789450.5.1.13701.2.2008
18235434Protein production and purification.Gräslund S, Nordlund P, Weigelt J, Hallberg BM, Bray J, Gileadi O, Knapp S, Oppermann U, Arrowsmith C, Hui R, Ming J, dhe-Paganon S, Park HW, Savchenko A, Yee A, Edwards A, Vincentelli R, Cambillau C, Kim R, Kim SH, Rao Z, Shi Y, Terwilliger TC, Kim CY, Hung LW, Waldo GS, Peleg Y, Albeck S, Unger T, Dym O, Prilusky J, Sussman JL, Stevens RC, Lesley SA, Wilson IA, Joachimiak A, Collart F, Dementieva I, Donnelly MI, Eschenfeldt WH, Kim Y, Stols L, Wu R, Zhou M, Burley SK, Emtage JS, Sauder JM, Thompson D, Bain K, Luz J, Gheyi T, Zhang F, Atwell S, Almo SC, Bonanno JB, Fiser A, Swaminathan S, Studier FW, Chance MR, Sali A, Acton TB, Xiao R, Zhao L, Ma LC, Hunt JF, Tong L, Cunningham K, Inouye M, Anderson S, Janjua H, Shastry R, Ho CK, Wang D, Wang H, Jiang M, Montelione GT, Stuart DI, Owens RJ, Daenke S, Schütz A, Heinemann U, Yokoyama S, Büssow K, Gunsalus KC5(2):135-46Nat. Methods10.1038/nmeth.f.20201.02.2008
18056714Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants.Taylor PL, Blakely KM, de Leon GP, Walker JR, McArthur F, Evdokimova E, Zhang K, Valvano MA, Wright GD, Junop MS283(5):2835-45J. Biol. Chem.10.1074/jbc.M70616320001.02.2008
18186464First crystallographic models of human TBC domains in the context of a family-wide structural analysis.Tempel W, Tong Y, Dimov S, Bochkarev A, Park H71(1):497-502Proteins10.1002/prot.2188512.01.2008
18062662SALMON: solvent accessibility, ligand binding, and mapping of ligand orientation by NMR spectroscopy.Ludwig C,Michiels PJ,Wu X,Kavanagh KL,Pilka E,Jansson A,Oppermann U,Gunther UL. 51(1):1-3Journal of medicinal chemistryhttp://dx.doi.org/10.1021/jm701020f 10/01/2008
18062662SALMON: solvent accessibility, ligand binding, and mapping of ligand orientation by NMR spectroscopy.Ludwig, C; Michiels, PJA; Wu, X; Kavanagh, KL; Pilka, E; Jansson, A; Oppermann, U; Günther, UL; 51:1-3Journal of Medicinal Chemistry10.1021/jm701020f10.1.2008
Baculovirus expression vector system: An emerging host for high-throughput eukaryotic protein expressionShrestha, B; Smee, C; Gileadi, O; 439:269-289Methods in Molecular Biology10.1007/978-1-59745-188-8_191.1.2008
Primary ductal carcinoma in situ mammosphere formation: importance of the epidermal growth factor and Notch receptor signalling pathways.Farnie, G; Spence, K; Brennan, K; Bundred, NJ; Clarke, RB; 10:P94-P94Breast Cancer Research10.1186/bcr197801.1.2008
18370110Baculovirus expression vector system: an emerging host for high-throughput eukaryotic protein expression.Shrestha, B; Smee, C; Gileadi, O; 439:269-289Methods in Molecular Biology10.1007/978-1-59745-188-8_1901.01.2008
18542867High throughput production of recombinant human proteins for crystallography.Gileadi, O; Burgess-Brown, NA; Colebrook, SM; Berridge, G; Savitsky, P; Smee, CEA; Loppnau, P; Johansson, C; Salah, E; Pantic, NH; 426:221-246Methods in Molecular Biology10.1007/978-1-60327-058-8_1401.01.2008
Interaction of the active site threonine 201 sidechain with the nitrogen of nttrogen-containing bisphosphonates is not essential for slow tight inhibition to farnesyl pyrophosphate synthaseDunford, JE; Pilka, E; Kwaasi, AA; Evdokimov, A; Barnett, BL; Oppermann, U; Ebetino, FH; Russell, RG; Kavanagh, KL; 82:S223-S223Calcified Tissue International01.01.2008
Novel approaches to the therapy of rheumatoid arthritis based on an understanding of disease mechanismsMcCann, FE; Williams, RO; 8:275-284Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry10.2174/1871522087857483591.9.2008
18425743Similar biological activities of two isostructural ruthenium and osmium complexes.Maksimoska, J; Williams, DS; Atilla-Gokcumen, GE; Smalley, KSM; Carroll, PJ; Webster, RD; Filippakopoulos, P; Knapp, S; Herlyn, M; Meggers, E; 14:4816-4822Chemistry - A European Journal10.1002/chem.20080029401.01.2008
18184589Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecture.Eswaran, J; Bernad, A; Ligos, JM; Guinea, B; Debreczeni, JE; Sobott, F; Parker, SA; Najmanovich, R; Turk, BE; Knapp, S; 16:115-124Structure10.1016/j.str.2007.10.02601.1.2008
18571501Thermal unfolding of the archaeal DNA and RNA binding protein Ssh10.Wu, X; Oppermann, M; Berndt, KD; Bergman, T; Jörnvall, H; Knapp, S; Oppermann, U; 373:482-487Biochemical and Biophysical Research Communications10.1016/j.bbrc.2008.06.0305.9.2008
18388943Protocol for the induction of arthritis in C57BL/6 mice.Inglis, JJ; Simelyte, E; McCann, FE; Criado, G; Williams, RO; 3:612-618Nature Protocols10.1038/nprot.2008.1901.1.2008
18631752Perspectives of Alzheimer's disease treatments.Davis, JB; Bountra, C; Richardson, J; 89:273-290Handbook of Clinical Neurology10.1016/S0072-9752(07)01226-201.01.2008
18681966Prolactin receptor antagonism reduces the clonogenic capacity of breast cancer cells and potentiates doxorubicin and paclitaxel cytotoxicity.Howell, SJ; Anderson, E; Hunter, T; Farnie, G; Clarke, RB; 10:R68-Breast Cancer Research10.1186/bcr212901.1.2008
19029627Are stem-like cells responsible for resistance to therapy in breast cancer?O'Brien, CS; Farnie, G; Howell, SJ; Clarke, RB; 29:83-89Breast Disease01.1.2008
17916560Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain.Tong Y, Chugha P, Hota PK, Alviani RS, Li M, Tempel W, Shen L, Park HW, Buck M282(51):37215-24J. Biol. Chem.10.1074/jbc.M70380020021.12.2007
18077363A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.Fedorov, O; Marsden, B; Pogacic, V; Rellos, P; Müller, S; Bullock, AN; Schwaller, J; Sundström, M; Knapp, S; 104:20523-20528Proceedings of the National Academy of Sciences10.1073/pnas.070880010411.12.2007
18078381Evaluation of micro-parallel liquid chromatography as a method for HTS-coupled actives verification.Simeonov, A; Yasgar, A; Klumpp, C; Zheng, W; Shafqat, N; Oppermann, U; Austin, CP; Inglese, J; 5:815-824ASSAY and Drug Development Technologies10.1089/adt.2007.09701.12.2007
17982461In situ proteolysis for protein crystallization and structure determination.Dong A, Xu X, Edwards AM; Midwest Center for Structural Genomics; Structural Genomics Consortium, Chang C, Chruszcz M, Cuff M, Cymborowski M, Di Leo R, Egorova O, Evdokimova E, Filippova E, Gu J, Guthrie J, Ignatchenko A, Joachimiak A, Klostermann N, Kim Y, Korniyenko Y, Minor W, Que Q, Savchenko A, Skarina T, Tan K, Yakunin A, Yee A, Yim V, Zhang R, Zheng H, Akutsu M, Arrowsmith C, Avvakumov GV, Bochkarev A, Dahlgren LG, Dhe-Paganon S, Dimov S, Dombrovski L, Finerty P Jr, Flodin S, Flores A, Gräslund S, Hammerström M, Herman MD, Hong BS, Hui R, Johansson I, Liu Y, Nilsson M, Nedyalkova L, Nordlund P, Nyman T, Min J, Ouyang H, Park HW, Qi C, Rabeh W, Shen L, Shen Y, Sukumard D, Tempel W, Tong Y, Tresagues L, Vedadi M, Walker JR, Weigelt J, Welin M, Wu H, Xiao T, Zeng H, Zhu H.4(12):1019-21Nat Methods01.12.2007
18171622The use of systematic N- and C-terminal deletions to promote production and structural studies of recombinant proteins.Gräslund S, Sagemark J, Berglund H, Dahlgren LG, Flores A, Hammarström M, Johansson I, Kotenyova T, Nilsson M, Nordlund P, Weigelt J58(2):210-21Protein Expr. Purif.10.1016/j.pep.2007.11.00822.11.2007
18026117L3MBTL1 recognition of mono- and dimethylated histones.Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH14(12):1229-30Nat. Struct. Mol. Biol.10.1038/nsmb134018.11.2007
17996702Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture.Hassler, M; Singh, S; Yue, WW; Luczynski, M; Lakbir, R; Sanchez-Sanchez, F; Bader, T; Pearl, LH; Mittnacht, S; 28:371-385Molecular Cell10.1016/j.molcel.2007.08.0239.11.2007
17928139Voltage-gated ion channel Nav1.7 innervation in patients with idiopathic rectal hypersensitivity and paroxysmal extreme pain disorder (familial rectal pain).Yiangou, Y; Facer, P; Chessell, IP; Bountra, C; Chan, C; Fertleman, C; Smith, V; Anand, P; 427:77-82Neuroscience Letters10.1016/j.neulet.2007.09.0275.11.2007
17982461In situ proteolysis for protein crystallization and structure determination.Dong A, Xu X, Edwards AM, Chang C, Chruszcz M, Cuff M, Cymborowski M, Di Leo R, Egorova O, Evdokimova E, Filippova E, Gu J, Guthrie J, Ignatchenko A, Joachimiak A, Klostermann N, Kim Y, Korniyenko Y, Minor W, Que Q, Savchenko A, Skarina T, Tan K, Yakunin A, Yee A, Yim V, Zhang R, Zheng H, Akutsu M, Arrowsmith C, Avvakumov GV, Bochkarev A, Dahlgren LG, Dhe-Paganon S, Dimov S, Dombrovski L, Finerty P, Flodin S, Flores A, Gräslund S, Hammerström M, Herman MD, Hong BS, Hui R, Johansson I, Liu Y, Nilsson M, Nedyalkova L, Nordlund P, Nyman T, Min J, Ouyang H, Park HW, Qi C, Rabeh W, Shen L, Shen Y, Sukumard D, Tempel W, Tong Y, Tresagues L, Vedadi M, Walker JR, Weigelt J, Welin M, Wu H, Xiao T, Zeng H, Zhu H4(12):1019-21Nat. Methods10.1038/nmeth111804.11.2007
18056045Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy.Russell, RGG; Xia, Z; Dunford, JE; Oppermann, U; Kwaasi, A; Hulley, PA; Kavanagh, KL; Triffitt, JT; Lundy, MW; Phipps, RJ; Barnett, BL; Coxon, FP; Rogers, MJ; Watts, NB; Ebetino, FH; 1117:209-257Annals of the New York Academy of Sciences10.1196/annals.1402.08901.11.2007
18022563Mechanism and substrate recognition of human holo ACP synthase.Bunkoczi, G; Pasta, S; Joshi, A; Wu, X; Kavanagh, KL; Smith, S; Oppermann, U; 14:1243-1253Cell Chemistry Biology10.1016/j.chembiol.2007.10.01301.11.2007
17997974Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation.Bullock, AN; Rodriguez, MC; Debreczeni, JE; Songyang, Z; Knapp, S; 15:1493-1504Structure10.1016/j.str.2007.09.01601.11.2007
17951720Structure determination of the motor domain of yeast kinesin kar3 by x-ray crystallography.Park HW392:199-211Methods Mol. Biol.10.1007/978-1-59745-490-2_1424.10.2007
17882261Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase.Yue, WW; Hassler, M; Roe, SM; Thompson-Vale, V; Pearl, LH; 26:4402-4412EMBO Journal10.1038/sj.emboj.760185617.10.2007
17822713Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO.Dufe VT, Qiu W, Müller IB, Hui R, Walter RD, Al-Karadaghi S373(1):167-77J. Mol. Biol.10.1016/j.jmb.2007.07.05312.10.2007
17656365Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases.Wu H, Dombrovsky L, Tempel W, Martin F, Loppnau P, Goodfellow GH, Grant DM, Plotnikov AN282(41):30189-97J. Biol. Chem.10.1074/jbc.M70413820012.10.2007
17914902Nicotinamide riboside kinase structures reveal new pathways to NAD+.Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C5(10):e263PLoS Biol.10.1371/journal.pbio.005026302.10.2007
17521371Activating and inhibitory receptors on synovial fluid natural killer cells of arthritis patients: role of CD94/NKG2A in control of cytokine secretionde Matos CT, Berg L, Michaelsson J, Fellander-Tsai L, Karre K, Soderstrom K. 122(2):291-301Immunology10.1111/j.1365-2567.2007.02638.x2007 Oct.
Cytotoxic hybrids between the aromatic alkaloids bauerine C and rutaecarpineHuber, K; Bracher, F; 62:1313-1316Zeitschrift fur Naturforschung B01.10.2007
17937911Structural and functional characterization of the human protein kinase ASK1.Bunkoczi, G; Salah, E; Filippakopoulos, P; Fedorov, O; Müller, S; Sobott, F; Parker, SA; Zhang, H; Min, W; Turk, BE; Knapp, S; 15:1215-1226Structure10.1016/j.str.2007.08.01101.10.2007
17631502Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.Hong BS, Senisterra G, Rabeh WM, Vedadi M, Leonardi R, Zhang YM, Rock CO, Jackowski S, Park HW282(38):27984-93J. Biol. Chem.10.1074/jbc.M70191520021.09.2007
17853878The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability.Niesen FH, Berglund H, Vedadi M2(9):2212-21Nat Protoc10.1038/nprot.2007.32115.09.2007
17635811The expression of human natural killer cell receptors in early lifeSundstrom Y, Nilsson C, Lilja G, Karre K, Troye-Blomberg M, Berg L. 66(2-3):335-44Scand J Immunol.10.1111/j.1365-3083.2007.01980.xAug-Sep 2007
17605758Membranous structures transfer cell surface proteins across NK cell immune synapses.Williams, GS; Collinson, LM; Brzostek, J; Eissmann, P; Almeida, CR; McCann, FE; Burshtyn, D; Davis, DM; 8:1190-1204Traffic10.1111/j.1600-0854.2007.00603.x01.9.2007
17932789The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins.Gileadi, O; Knapp, S; Lee, WH; Marsden, BD; Müller, S; Niesen, FH; Kavanagh, KL; Ball, LJ; von Delft, F; Doyle, DA; Oppermann, UCT; Sundström, M; 8:107-119Journal of Structural and Functional Genomics10.1007/s10969-007-9027-201.9.2007
17804748Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases.Bettayeb, K; Tirado, OM; Marionneau-Lambot, S; Ferandin, Y; Lozach, O; Morris, JC; Mateo-Lozano, S; Drueckes, P; Schächtele, C; Kubbutat, MHG; Liger, F; Marquet, B; Joseph, B; Echalier, A; Endicott, JA; Notario, V; Meijer, L; 67:8325-8334Cancer Research10.1158/0008-5472.can-07-182601.9.2007
17582772Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score.Yilmaz, Z; Renton, T; Yiangou, Y; Zakrzewska, J; Chessell, IP; Bountra, C; Anand, P; 14:864-871Journal of Clinical Neuroscience10.1016/j.jocn.2006.09.00201.9.2007
19636837Backbone and sidechain 1H, 13C and 15N resonance assignments of the RGS domain from human RGS14.Dowler, EF; Diehl, A; Schmieder, P; Brockmann, C; Elkins, J; Soundararajan, M; Oschkinat, H; Ball, LJ; 1:95-97Biomolecular NMR Assignments10.1007/s12104-007-9029-97.7.2007
17627826Activation segment exchange: a common mechanism of kinase autophosphorylation?Oliver, AW; Knapp, S; Pearl, LH; 32:351-356Trends in Biochemical Sciences10.1016/j.tibs.2007.06.0041.8.2007
17585781Structure and mechanism of spermidine synthases.Wu H, Min J, Ikeguchi Y, Zeng H, Dong A, Loppnau P, Pegg AE, Plotnikov AN46(28):8331-9Biochemistry10.1021/bi602498k17.07.2007
17638903Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity.Pogacic, V; Bullock, AN; Fedorov, O; Filippakopoulos, P; Gasser, C; Biondi, A; Meyer-Monard, S; Knapp, S; Schwaller, J; 67:6916-6924Cancer Research10.1158/0008-5472.can-07-032001.7.2007
17589501Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.Ng, SS; Kavanagh, KL; McDonough, MA; Butler, D; Pilka, ES; Lienard, BMR; Bray, JE; Savitsky, P; Gileadi, O; von Delft, F; Rose, NR; Offer, J; Scheinost, JC; Borowski, T; Sundstrom, M; Schofield, CJ; Oppermann, U; 448:87-91Nature10.1038/nature059715.7.2007
17620727Crystallization and preliminary X-ray analysis of phage Mu activator protein C in a complex with promoter DNA.Shanmuganatham KK, Ravichandran M, Howe MM, Park HW63(Pt 7):620-3Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.10.1107/S174430910702528601.07.2007
17410582Crystal structure of a binary complex between human GCN5 histone acetyltransferase domain and acetyl coenzyme A.Schuetz A, Bernstein G, Dong A, Antoshenko T, Wu H, Loppnau P, Bochkarev A, Plotnikov AN68(1):403-7Proteins10.1002/prot.2140701.07.2007
Nitrogen-containing bisphosphonates and prediction of their clinical potencies: Dissociation of target enzyme- and hydroxyapatite-binding affinitiesXia, Z; Dunford, J; Lawson, MA; Triffitt, JT; Kavanagh, K; Oppermann, U; Barnett, BL; Ebetino, FH; Russell, RGG; 22:1125-1125Journal of Bone and Mineral Research01.7.2007
17405878Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition.Walldén K, Stenmark P, Nyman T, Flodin S, Gräslund S, Loppnau P, Bianchi V, Nordlund P282(24):17828-36J. Biol. Chem.10.1074/jbc.M70091720015.06.2007
17491595Atomic resolution insight into host cell recognition by Toxoplasma gondii.Blumenschein, TMA; Friedrich, N; Childs, RA; Saouros, S; Carpenter, EP; Campanero-Rhodes, MA; Simpson, P; Chai, W; Koutroukides, T; Blackman, MJ; Feizi, T; Soldati-Favre, D; Matthews, S; 26:2808-2820EMBO Journal10.1038/sj.emboj.76017046.6.2007
17426033Glyoxylate and pyruvate are antagonistic effectors of the Escherichia coli IclR transcriptional regulator.Lorca GL, Ezersky A, Lunin VV, Walker JR, Altamentova S, Evdokimova E, Vedadi M, Bochkarev A, Savchenko A282(22):16476-91J. Biol. Chem.10.1074/jbc.M61083820001.06.2007
17447011Protein-protein interaction site mapping using NMR-detected mutational scanningBaminger, B; Ludwiczek, ML; Kontaxis, G; Knapp, S; Konrat, R; 38:133-137Journal of Biomolecular NMR10.1007/s10858-007-9154-x1.6.2007
Breast cancer stem cells: Potential therapeutic targetsHowell, SJ; Farnie, G; Clarke, RB; 4:51-53Advances in Breast Cancer -London-1.6.2007
17873349Mammary stem cells and breast cancer--role of Notch signalling.Farnie, G; Clarke, RB; 3:169-175Stem Cell Reviews and Reports10.1007/s12015-007-0023-501.6.2007
Predicting pharmacological potencies of nitrogen-containing bisphosphonates; novel methods dissociate enzyme- and hydroxyapatite-binding affinitiesXia, Z; Dunford, J; Lawson, MA; Triffitt, JT; Kavanagh, K; Oppermann, U; Roze, C; Kashemirov, B; McKenna, CE; Ebetino, FH; Russell, RG; 40:S301-S302BONE01.6.2007
17392278Specificity profiling of Pak kinases allows identification of novel phosphorylation sitesRennefahrt, UEE; Deacon, SW; Parker, SA; Devarajan, K; Beeser, A; Chernoff, J; Knapp, S; Turk, BE; Peterson, JR; 282:15667-15678Journal of Biological Chemistry10.1074/jbc.M70025320025.5.2007
17429992Hexagonal close packing of nonionic surfactant micelles in water.Zeng X, Liu Y, Impéror-Clerc M111(19):5174-9J Phys Chem B10.1021/jp068795517.05.2007
17368478Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms.Rosettani, P; Knapp, S; Vismara, M-G; Rusconi, L; Cameron, AD; 368:691-705Journal of Molecular Biology10.1016/j.jmb.2007.02.0194.5.2007
17339318Interaction of hydroxylated collagen IV with the von-Hippel-Lindau tumor suppressor.Masson, N; Grosfeld A, ; Kessler B, ; Ratcliffe PJ, ; 282:13264-13269Journal of Biological Chemistry10.1074/jbc.M6116482004.5.2007
17442943Inhibitory receptor signals suppress ligation-induced recruitment of NKG2D to GM1-rich membrane domains at the human NK cell immune synapse.Endt, J; McCann, FE; Almeida, CR; Urlaub, D; Leung, R; Pende, D; Davis, DM; Watzl, C; 178:5606-5611Journal of Immunology10.4049/jimmunol.178.9.560601.5.2007
17467572Insights for the development of specific kinase inhibitors by targeted structural genomics.Fedorov, O; Sundström, M; Marsden, B; Knapp, S; 12:365-372Drug Discovery Today10.1016/j.drudis.2007.03.00601.5.2007
17397141Interactions of isopenicillin N synthase with cyclopropyl-containing substrate analogues reveal new mechanistic insight.Howard-Jones, AR; Elkins, JM; Clifton, IJ; Roach, PL; Adlington, RM; Baldwin, JE; Rutledge, PJ; 46:4755-4762Biochemistry10.1021/bi062314q24.4.2007
17440163Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways.Farnie, G; Clarke, RB; Spence, K; Pinnock, N; Brennan, K; Anderson, NG; Bundred, NJ; 99:616-627JNCI: Journal of the National Cancer Institute10.1093/jnci/djk13301.4.2007
17425406Structural and chemical profiling of the human cytosolic sulfotransferases.Allali-Hassani A, Pan PW, Dombrovski L, Najmanovich R, Tempel W, Dong A, Loppnau P, Martin F, Thornton J, Thonton J, Edwards AM, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH5(5):e97PLoS Biol.10.1371/journal.pbio.005009712.04.2007
17243178Structural basis of allele variation of human thiopurine-S-methyltransferase.Wu H, Horton JR, Battaile K, Allali-Hassani A, Martin F, Zeng H, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Cheng X67(1):198-208Proteins10.1002/prot.2127201.04.2007
16690336Changes in dorsal root ganglion CGRP expression in a chronic inflammatory model of the rat knee joint: differential modulation by rofecoxib and paracetamol.Staton, PC; Wilson, AW; Bountra, C; Chessell, IP; Day, NC; 11:283-289European Journal of Pain10.1016/j.ejpain.2006.03.00601.4.2007
Clinical and experimental pain processing in rheumatoid arthritis patients treated with anti-TNFWartolowska, K; Schweinhardt, P; Wordsworth, P; Chizh, BA; Bountra, C; Chessell, I; Tracey, I; 46:I6-I7Rheumatology01.4.2007
17384233Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.Elkins, JM; Papagrigoriou, E; Berridge, G; Yang, X; Phillips, C; Gileadi, C; Savitsky, P; Doyle, DA; 16:683-694Protein Science01.4.2007
17355872Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin.Schuetz A, Min J, Antoshenko T, Wang CL, Allali-Hassani A, Dong A, Loppnau P, Vedadi M, Bochkarev A, Sternglanz R, Plotnikov AN15(3):377-89Structure10.1016/j.str.2007.02.00216.03.2007
17339436The activating NKG2D ligand MHC class I-related chain A transfers from target cells to NK cells in a manner that allows functional consequences.McCann, FE; Eissmann, P; Onfelt, B; Leung, R; Davis, DM; 178:3418-3426Journal of Immunology10.4049/jimmunol.178.6.341801.3.2007
17339449Increased expression of leukocyte Ig-like receptor-1 and activating role of UL18 in the response to cytomegalovirus infectionWagner CS, Riise GC, Bergstrom T, Karre K, Carbone E, Berg L. 178(6):3536-43J Immunol.10.4049/jimmunol.178.6.35362007 Mar 15
17067289Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity.Lukacik, P; Keller, B; Bunkoczi, G; Kavanagh, KL; Lee, WH; Adamski, J; Oppermann, U; 402:419-427Biochemical Journal10.1042/BJ2006131915.3.2007
17290979A potent, covalent inhibitor of orotidine 5'-monophosphate decarboxylase with antimalarial activity.Bello AM, Poduch E, Fujihashi M, Amani M, Li Y, Crandall I, Hui R, Lee PI, Kain KC, Pai EF, Kotra LP50(5):915-21J. Med. Chem.10.1021/jm060827p08.03.2007
17318183AP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesis.Carpenter, EP; Corbett, A; Thomson, H; Adacha, J; Jensen, K; Bergeron, J; Kasampalidis, I; Exley, R; Winterbotham, M; Tang, C; Baldwin, GS; Freemont, P; 26:1363-1372EMBO Journal10.1038/sj.emboj.76015937.3.2007
17197699Structure and regulation of the human Nek2 centrosomal kinase.Rellos, P; Ivins, FJ; Baxter, JE; Pike, A; Nott, TJ; Parkinson, D-M; Das, S; Howell, S; Fedorov, O; Shen, QY; Fry, AM; Knapp, S; Smerdon, SJ; 282:6833-6842Journal of Biological Chemistry10.1074/jbc.m60972120001.3.2007
Structural genomics and drug discovery: Case studies on human metabolic enzymesOppermann, U; Kavanagh, KL; Guo, K; Ng, S; Shafqat, N; Danford, J; Rojkova, A; Pilka, E; Hozjan, V; Kochan, G; Wu, X; Lukacik, P; 375:69-69Naunyn-Schmiedeberg's Archives of Pharmacology01.3.2007
An NMR-based metabolic profiling study of inflammatory pain using the rat FCA modelConnor, SC; Gray, RA; Hodson, MP; Clayton, NM; Haselden, JN; Chessell, IP; Bountra, C; 3:29-39Metabolomics10.1007/s11306-006-0039-x1.3.2007
17298439Biochemical characterization of TASSELSEED 2, an essential plant short-chain dehydrogenase/reductase with broad spectrum activities.Wu, X; Knapp, S; Stamp, A; Stammers, DK; Jörnvall, H; Dellaporta, SL; Oppermann, U; 274:1172-1182European Journal of Biochemistry10.1111/j.1742-4658.2007.05642.x01.3.2007
17157313The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition.Davis TL, Walker JR, Finerty PJ, Mackenzie F, Newman EM, Dhe-Paganon S366(1):216-29J. Mol. Biol.10.1016/j.jmb.2006.11.03709.02.2007
17285134Cyclooxygenase-2 inhibition: effects on tumour growth, cell cycling and lymphangiogenesis in a xenograft model of breast cancer.Barnes, NLP; Warnberg, F; Farnie, G; White, D; Jiang, W; Anderson, E; Bundred, NJ; 96:575-582British Journal of Cancer10.1038/sj.bjc.66035936.2.2007
17138556Crystal structure of human inosine triphosphatase. Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T.Stenmark P, Kursula P, Flodin S, Gräslund S, Landry R, Nordlund P, Schüler H282(5):3182-7J. Biol. Chem.10.1074/jbc.M60983820002.02.2007
17121859Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria.Johansson, C; Kavanagh, KL; Gileadi, O; Oppermann, U; 282:3077-3082Journal of Biological Chemistry10.1074/jbc.M6081792002.2.2007
17234335SDR-type human hydroxysteroid dehydrogenases involved in steroid hormone activation.Wu, X; Lukacik, P; Kavanagh, KL; Oppermann, U; 265-266:71-76Molecular and Cellular Endocrinology10.1016/j.mce.2006.12.00601.2.2007
17305715The effect of inflammation on Fos expression in the ferret trigeminal nucleus.Worsley, MA; Davies, SL; Clayton, NM; Bountra, C; Loescher, AR; Robinson, PP; Boissonade, FM; 115:40-47European Journal of Oral Sciences10.1111/j.1600-0722.2007.00411.x01.2.2007
17292838Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs.Eswaran, J; Lee, WH; Debreczeni, JE; Filippakopoulos, P; Turnbull, A; Fedorov, O; Deacon, SW; Peterson, JR; Knapp, S; 15:201-213Structure10.1016/j.str.2007.01.00101.2.2007
17037982The centaurin gamma-1 GTPase-like domain functions as an NTPase.Soundararajan, M; Yang, X; Elkins, JM; Sobott, F; Doyle, DA; 401:679-688Biochemical Journal10.1042/BJ200605551.2.2007
Total Synthesis of RapamycinMaddess, ML; Tackett, MN; Watanabe, H; Brennan, PE; Spilling, CD; Scott, JS; Osborn, DP; Ley, SV; 46:591-597Angewandte Chemie International Edition10.1002/anie.20060405315.1.2007
17237076Analysis of binding site similarity, small-molecule similarity and experimental binding profiles in the human cytosolic sulfotransferase family.Najmanovich RJ, Allali-Hassani A, Morris RJ, Dombrovsky L, Pan PW, Vedadi M, Plotnikov AN, Edwards A, Arrowsmith C, Thornton JM23(2):e104-9Bioinformatics10.1093/bioinformatics/btl29215.01.2007
16887195Localized and non-contact mechanical stimulation of dorsal root ganglion sensory neurons using scanning ion conductance microscopy.Sánchez, D; Anand, U; Gorelik, J; Benham, CD; Bountra, C; Lab, M; Klenerman, D; Birch, R; Anand, P; Korchev, Y; 159:26-34Journal of Neuroscience Methods10.1016/j.jneumeth.2006.06.01815.1.2007
Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cellsVogler, M; Dürr, K; Jovanovic, M; Debatin, K-M; Fulda, S; 26:248-257Oncogene10.1038/sj.onc.120977601.1.2007
17009925Carbonyl reductases: the complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology.O, U; p, ; p, ; e, ; r, ; m, ; a, ; n, ; n, ; 47:293-322Annual Review of Pharmacology and Toxicology10.1146/annurev.pharmtox.47.120505.10531601.01.2007
Erratum: Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity (Biochemical Journal (2007) 402, (419-427))Lukacik, P; Keller, B; Bunkoczi, G; Kavanagh, KL; Lee, WH; Adamski, J; Oppermann, U; 403:615-Biochemical Journal1.5.2007
Kinetic analysis of conformational changes in farnesyl pyrophosphate synthase induced by nitrogen containing bisphosphonatesDunford, JE; Kavanagh, KL; Rogers, MJ; Oppermann, U; Ebetin, FH; Russell, G; 80:S41-S42Calcified Tissue International01.01.2007
17521436Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy.Facer, P; Casula, MA; Smith, GD; Benham, CD; Chessell, IP; Bountra, C; Sinisi, M; Birch, R; Anand, P; 7:11-BMC Neurology10.1186/1471-2377-7-1123.5.2007
17584164High-level bacterial expression and purification of apicomplexan micronemal proteins for structural studies.Saouros, S; Blumenschein, TMA; Sawmynaden, K; Marchant, J; Koutroukides, T; Liu, B; Simpson, P; Carpenter, EP; Matthews, SJ; 14:411-415Protein and Peptide Letters01.01.2007
17683543Use of the novel Contact Heat Evoked Potential Stimulator (CHEPS) for the assessment of small fibre neuropathy: correlations with skin flare responses and intra-epidermal nerve fibre counts.Atherton, DD; Facer, P; Roberts, KM; Misra, VP; Chizh, BA; Bountra, C; Anand, P; 7:21-BMC Neurology10.1186/1471-2377-7-213.8.2007
The cell-binding region of Toxoplasma gondii micronemal protein 1 presents a novel foldBlumenschein, TMA; Carpenter, EP; Saciuros, S; Friedrich, N; Koutroukides, T; Soldati, D; Matthews, S; :43A-43ABiophysical Journal01.1.2007
17180548Resonance assignment of the RGS domain of human RGS10.Fedorov, OY; Higman, VA; Schmieder, P; Leidert, M; Diehl, A; Elkins, J; Soundararajan, M; Oschkinat, H; Ball, LJ; 38:191-Journal of Biomolecular NMR10.1007/s10858-006-9111-001.6.2007
18376450Molecular replacementMurshudov, G; Von Delft, F; Ballard, C; 64:-Acta Crystallographica Section D: Biological Crystallography10.1107/S09074449070587144.12.2007
16935945Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice.Sitia, G; Iannacone, M; Müller, S; Bianchi, ME; Guidotti, LG; 81:100-107Journal of Leukocyte Biology10.1189/jlb.030617301.1.2007
17035239Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8).Avvakumov GV, Walker JR, Xue S, Finerty PJ, Mackenzie F, Newman EM, Dhe-Paganon S281(49):38061-70J. Biol. Chem.10.1074/jbc.M60670420008.12.2006
16964532NMR assignment of human RGS18.Higman, VA; Leidert, M; Diehl, A; Elkins, J; Soundararajan, M; Oschkinat, H; Ball, LJ; 36 Suppl 1:72-Journal of Biomolecular NMR10.1007/s10858-006-9061-601.1.2006
17085597Structural basis for protein-protein interactions in the 14-3-3 protein family.Yang, X; Lee, WH; Sobott, F; Papagrigoriou, E; Robinson, CV; Grossmann, JG; Sundström, M; Doyle, DA; Elkins, JM; 103:17237-17242Proceedings of the National Academy of Sciences10.1073/pnas.060577910314.11.2006
17125854Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.Vedadi M, Lew J, Artz J, Amani M, Zhao Y, Dong A, Wasney GA, Gao M, Hills T, Brokx S, Qiu W, Sharma S, Diassiti A, Alam Z, Melone M, Mulichak A, Wernimont A, Bray J, Loppnau P, Plotnikova O, Newberry K, Sundararajan E, Houston S, Walker J, Tempel W, Bochkarev A, Kozieradzki I, Edwards A, Arrowsmith C, Roos D, Kain K, Hui R151(1):100-10Mol. Biochem. Parasitol.10.1016/j.molbiopara.2006.10.01113.11.2006
17092916Screening for ligands using a generic and high-throughput light-scattering-based assay.Senisterra GA, Markin E, Yamazaki K, Hui R, Vedadi M, Awrey DE11(8):940-8J Biomol Screen10.1177/108705710629469907.11.2006
16973127Structure of human protein kinase C eta (PKCeta) C2 domain and identification of phosphorylation sites.Littler DR, Walker JR, She YM, Finerty PJ, Newman EM, Dhe-Paganon S349(4):1182-9Biochem. Biophys. Res. Commun.10.1016/j.bbrc.2006.08.16003.11.2006
16908020Changes in sodium channel expression following trigeminal nerve injury.Davies, SL; Loescher, AR; Clayton, NM; Bountra, C; Robinson, PP; Boissonade, FM; 202:207-216Experimental Neurology10.1016/j.expneurol.2006.05.03501.11.2006
17035505Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination.Vedadi M, Niesen FH, Allali-Hassani A, Fedorov OY, Finerty PJ, Wasney GA, Yeung R, Arrowsmith C, Ball LJ, Berglund H, Hui R, Marsden BD, Nordlund P, Sundstrom M, Weigelt J, Edwards AM103(43):15835-40Proc. Natl. Acad. Sci. U.S.A.10.1073/pnas.060522410324.10.2006
17034127Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold.Hardcastle, IR; Ahmed, SU; Atkins, H; Farnie, G; Golding, BT; Griffin, RJ; Guyenne, S; Hutton, C; Källblad, P; Kemp, SJ; Kitching, MS; Newell, DR; Norbedo, S; Northen, JS; Reid, RJ; Saravanan, K; Willems, HMG; Lunec, J; 49:6209-6221Journal of Medicinal Chemistry10.1021/jm060119401.10.2006
16919785MAPK-specific tyrosine phosphatases: new targets for drug discovery?Barr, AJ; Knapp, S; 27:525-530Trends in Pharmacological Sciences10.1016/j.tips.2006.08.00501.10.2006
16986120Pharmacological FMRI in the development of new analgesic compounds.Schweinhardt, P; Bountra, C; Tracey, I; 19:702-711NMR in Biomedicine10.1002/nbm.107601.10.2006
16946699Structural basis for molecular recognition and presentation of histone H3 by WDR5.Schuetz A, Allali-Hassani A, Martín F, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Arrowsmith CH, Min J25(18):4245-52EMBO J.10.1038/sj.emboj.760131620.09.2006
17017977Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases?Oppermann U.6(3):259-269Endocrine, metabolic & immune disorders drug targetshttp://www.eurekaselect.com/77053/article01/09/2006
16929107Development of an automated large-scale protein-crystallization and monitoring system for high-throughput protein-structure analyses.Hiraki M, Kato R, Nagai M, Satoh T, Hirano S, Ihara K, Kudo N, Nagae M, Kobayashi M, Inoue M, Uejima T, Oda S, Chavas LM, Akutsu M, Yamada Y, Kawasaki M, Matsugaki N, Igarashi N, Suzuki M, Wakatsuki S.62(Pt 9):1058-65Acta Crystallogr D Biol Crystallogr10.1107/S090744490602382101.09.2006
16804942Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP).Dombrovski L, Dong A, Bochkarev A, Plotnikov AN64(4):1091-4Proteins10.1002/prot.2104801.09.2006
Analysis of the kinetic mechanism of inhibition of Farnesyl Pyrophosphate Synthase by nitrogen containing bisphosphonates.Dunford, JE; Kavanagh, K; Oppermann, U; Ebetino, EH; Russell, RGG; Rogers, MJ; 21:S396-S397Journal of Bone and Mineral Research01.9.2006
17017977Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases?O, U; p, ; p, ; e, ; r, ; m, ; a, ; n, ; n, ; 6:259-269Endocrine, Metabolic and Immune Disorders - Drug Targets01.9.2006
Direct observation of RuvAB-catalyzed branch migration of single Holliday junctions (vol 101, pg 11605, 2004)Amit, R; Gileadi, O; Stavans, J; 103:12654-12654Proceedings of the National Academy of Sciences15.8.2006
16698791The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding.Kavanagh, KL; Dunford, JE; Bunkoczi, G; Russell, RGG; Oppermann, U; 281:22004-22012Journal of Biological Chemistry10.1074/jbc.M6026032004.8.2006
16199187An animal model of chronic inflammatory pain: pharmacological and temporal differentiation from acute models.Wilson, AW; Medhurst, SJ; Dixon, CI; Bontoft, NC; Winyard, LA; Brackenborough, KT; De Alba, J; Clarke, CJ; Gunthorpe, MJ; Hicks, GA; Bountra, C; McQueen, DS; Chessell, IP; 10:537-549European Journal of Pain10.1016/j.ejpain.2005.08.00301.8.2006
16679031An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients.Schweinhardt, P; Glynn, C; Brooks, J; McQuay, H; Jack, T; Chessell, I; Bountra, C; Tracey, I; 32:256-265NeuroImage10.1016/j.neuroimage.2006.03.0241.8.2006
Normal NK cell development in absence of Aire.Lundgren EK, Rosmaraki E, Berg L, Hoglund P, Winqvist O176; S280-S280Journal of Immunology2006
NK cells in autoimmune diseaseJohansson S, Hall H, Berg L, Hoglund P. 298; 259-77Immunobiology of Natural Killer Cell Receptors2006
16534812Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution.Barr, AJ; Debreczeni, JE; Eswaran, J; Knapp, S; 63:1132-1136Proteins10.1002/prot.209581.6.2006
16672235The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1.Eswaran, J; Debreczeni, JE; Longman, E; Barr, AJ; Knapp, S; 15:1500-1505Protein Science10.1110/ps.06212870601.6.2006
16675548Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase.Bullock AN, Debreczeni JE, Edwards AM, Sundström M, Knapp S103(20):7637-42Proc. Natl. Acad. Sci. U.S.A.10.1073/pnas.060163810316.05.2006
16684881The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.Kavanagh, KL; Guo, K; Dunford, JE; Wu, X; Knapp, S; Ebetino, FH; Rogers, MJ; Russell, RGG; Oppermann, U; 103:7829-7834Proceedings of the National Academy of Sciences10.1073/pnas.060164310316.5.2006
16481104The effect of neurotrophic factors on morphology, TRPV1 expression and capsaicin responses of cultured human DRG sensory neurons.Anand, U; Otto, WR; Casula, MA; Day, NC; Davis, JB; Bountra, C; Birch, R; Anand, P; 399:51-56Neuroscience Letters10.1016/j.neulet.2006.01.04615.5.2006
16669651Searching for cyclin-dependent kinase inhibitors using a new variant of the cope elimination.Griffin, RJ; Henderson, A; Curtin, NJ; Echalier, A; Endicott, JA; Hardcastle, IR; Newell, DR; Noble, MEM; Wang, L-Z; Golding, BT; 128:6012-6013Journal of the American Chemical Society10.1021/ja060595j01.5.2006
16441242Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.Eswaran, J; von Kries, JP; Marsden, B; Longman, E; Debreczeni, JE; Ugochukwu, E; Turnbull, A; Lee, WH; Knapp, S; Barr, AJ; 395:483-491Biochemical Journal10.1042/BJ200519311.5.2006
16461395Gas phase characterization of the noncovalent quaternary structure of cholera toxin and the cholera toxin B subunit pentamerWilliams, JP; Smith, DC; Green, BN; Marsden, BD; Jennings, KR; Roberts, LM; Scrivens, JH; 90:3246-3254Biophysical Journal10.1529/biophysj.105.0764551.1.2006
16685466Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue.Shafqat, N; Shafqat, J; Eissner, G; Marschall, H-U; Tryggvason, K; Eriksson, U; Gabrielli, F; Lardy, H; Jörnvall, H; Oppermann, U; 63:1205-1213Cellular and Molecular Life Sciences10.1007/s00018-006-6013-y01.5.2006
16380372Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase.Guo, K; Lukacik, P; Papagrigoriou, E; Meier, M; Lee, WH; Adamski, J; Oppermann, U; 281:10291-10297Journal of Biological Chemistry10.1074/jbc.M51134620014.4.2006
16434100Structure and mechanism in the bacterial dihaem cytochrome c peroxidases.Pettigrew, GW; Echalier, A; Pauleta, SR; 100:551-567Journal of Inorganic Biochemistry10.1016/j.jinorgbio.2005.12.00801.4.2006
16431016Active site variability of type 1 11beta-hydroxysteroid dehydrogenase revealed by selective inhibitors and cross-species comparisons.Hult, M; Shafqat, N; Elleby, B; Mitschke, D; Svensson, S; Forsgren, M; Barf, T; Vallgårda, J; Abrahmsen, L; Oppermann, U; 248:26-33Molecular and Cellular Endocrinology10.1016/j.mce.2005.11.04327.3.2006
16414178Structure and function of human 17beta-hydroxysteroid dehydrogenases.Lukacik, P; Kavanagh, KL; Oppermann, U; 248:61-71Molecular and Cellular Endocrinology10.1016/j.mce.2005.12.00727.3.2006
16474402Molecular recognition of p53 and MDM2 by USP7/HAUSPSheng Y, Saridakis V, Sarkari F, Duan S, Wu T, Arrowsmith CH, Frappier L.13(3):285-91Nat Struct Mol Biol.03.2006
Crystal structures and molecular interactions of risedronate and zoledronate with human farnesyl diphosphate synthaseKavanagh, KL; Guo, K; Wu, X; Knapp, S; Ebetino, FH; Dunford, JE; Rogers, MJ; Russell, RGG; Oppermann, U; 38:53-53BONE10.1016/j.bone.2005.12.05001.3.2006
Human farnesyl diphosphate synthase crystal structures with active and inactive bisphosphonatesEvdokimov, A; Pokross, M; Barnett, BL; Kavanagh, K; Oppermann, U; Russell, RGG; McKenna, CE; Ebetino, FH; 38:S49-S49BONE10.1016/j.bone.2005.12.04101.3.2006
Investigations into the kinetic mechanism of inhibition of farnesyl diphosphate synthase by nitrogen containing bisphosphonatesDunford, JE; Kavanagh, K; Oppermann, U; Ebetino, FH; Russell, RGG; Rogers, MJ; 38:S47-S48BONE10.1016/j.bone.2005.12.03701.3.2006
Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthaseEbetino, FH; Kashemirov, B; McKenna, CE; Evdokimov, A; Pokross, M; Barnett, BL; Dunford, J; Kavanagh, K; Rogers, MJ; Lundy, MW; Oppermann, U; Russell, RGG; 38:S49-S50BONE10.1016/j.bone.2005.12.04201.3.2006
16381041Ruthenium half-sandwich complexes bound to protein kinase Pim-1.Debreczeni, JE; Bullock, AN; Atilla, GE; Williams, DS; Bregman, H; Knapp, S; Meggers, E; 45:1580-1585Angewandte Chemie International Edition10.1002/anie.20050346827.2.2006
16306042A comparative study of uracil-DNA glycosylases from human and herpes simplex virus type 1.Krusong, K; Carpenter, EP; Bellamy, SRW; Savva, R; Baldwin, GS; 281:4983-4992Journal of Biological Chemistry10.1074/jbc.M50913720024.2.2006
16406633Disseminating structural genomics data to the public: from a data dump to an animated storyAbagyan, R; Lee, WH; Raush, E; Budagyan, L; Totrov, M; Sundstrom, M; Marsden, BD; 31:76-78Trends in Biochemical Sciences10.1016/j.tibs.2005.12.00601.2.2006
Nogo-A and Nogo-66 receptor in multiple sclerosis and amyotrophic lateral sclerosis spinal cord and injured human peripheral nervesDurrenberger, P; Facer, P; Casula, MA; Prinjha, R; Moore, S; Woodhams, P; Bountra, C; Ravid, R; Birch, R; Anand, P; 77:130-130Journal of Neurology, Neurosurgery and Psychiatry01.1.2006
16407070Activation and catalysis of the di-heme cytochrome c peroxidase from Paracoccus pantotrophus.Echalier, A; Goodhew, CF; Pettigrew, GW; Fülöp, V; 14:107-117Structure10.1016/j.str.2005.09.01101.1.2006
SDR goes SGC: A structural genomics initiativeOppermann, U; Kavanagh, K; Guo, KD; Ng, S; Lukacik, P; Wu, XQ; Dubinina, E; Shafqat, N; Bray, J; Marsden, B; Sharma, S; Vedadi, M; von Delft, F; Sundstrom, M; 12:235-24101.01.2006
Erratum: Direct observation of RuvAB-catalyzed branch migration of single Holliday junctions (Proceedings of the National Academy of Sciences of the United States of America (August 10, 2004) 101, 32 (11605-11616): 10.1073/pnas.0404332101)Amit, R; Gileadi, O; Stavans, J; 103:12654-Proceedings of the National Academy of Sciences10.1073/pnas.060512210315.8.2006
High-throughput structural characterisation of therapeutic protein targetsMarsden, BD; Sundstrom, M; Knapp, S; 1:123-136Expert Opinion on Drug Discovery10.1517/17460441.1.2.1231.7.2006
Brain fMRI in clinical pharmacological studiesTracey, I; Schweinhardt, P; Bountra, C; :221-2361.1.2006
17939300Breast stem cells and cancer.Farnie, G; Clarke, RB; :141-15301.1.2006
16512913COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord.Yiangou, Y; Facer, P; Durrenberger, P; Chessell, IP; Naylor, A; Bountra, C; Banati, RR; Anand, P; 6:12-BMC Neurology10.1186/1471-2377-6-122.3.2006
16519806Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations.Mukerji, G; Yiangou, Y; Corcoran, SL; Selmer, IS; Smith, GD; Benham, CD; Bountra, C; Agarwal, SK; Anand, P; 6:6-BMC Urology10.1186/1471-2490-6-66.3.2006
16568448Inhibition of protein-protein interactions: The discovery of druglike β-catenin inhibitors by combining virtual and biophysical screeningTrosset, JY; Dalvit, C; Knapp, S; Fasolini, M; Veronesi, M; Mantegani, S; Gianellini, LM; Catana, C; Sundström, M; Stouten, PFW; Moll, JK; 64:60-67Proteins10.1002/prot.209551.7.2006
17192176Pain during ice water test distinguishes clinical bladder hypersensitivity from overactivity disorders.Mukerji, G; Waters, J; Chessell, IP; Bountra, C; Agarwal, SK; Anand, P; 6:31-BMC Urology10.1186/1471-2490-6-3127.12.2006
16227208Structure and substrate specificity of the Pim-1 kinase.Bullock, AN; Debreczeni, J; Amos, AL; Knapp, S; Turk, BE; 280:41675-41682Journal of Biological Chemistry10.1074/jbc.M51071120016.12.2005
16186124Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease.McDonough, MA; Kavanagh, KL; Butler, D; Searls, T; Oppermann, U; Schofield, CJ; 280:41101-41110Journal of Biological Chemistry10.1074/jbc.M5075282009.12.2005
16302800Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase.Bullock, AN; Debreczeni, JE; Fedorov, OY; Nelson, A; Marsden, BD; Knapp, S; 48:7604-7614Journal of Medicinal Chemistry10.1021/jm050485801.12.2005
16281059Structure of a central stalk subunit F of prokaryotic V-type ATPase/synthase from Thermus thermophilus.Makyio, H; Iino, R; Ikeda, C; Imamura, H; Tamakoshi, M; Iwata, M; Stock, D; Bernal, RA; Carpenter, EP; Yoshida, M; Yokoyama, K; Iwata, S; 24:3974-3983EMBO Journal10.1038/sj.emboj.760085916.11.2005
Enzymology and Molecular Biology of Carbonyl MetabolismMarsden, B; Oppermann, U; Kavanagh, K; Guo, K; Ng, S; Lukacik, P; Wu, X; Dubinia, E; Shafqat, N; Bray, J; Sharma, S; Vedadi, M; 12:-11.11.2005
16118064NK cells: elusive players in autoimmunityJohansson S, Berg L, Hall H, Hoglund P. 26(11):613-8Trends Immunol10.1016/j.it.2005.08.008Nov. 2005
16166556Exogenous high-mobility group box 1 protein induces myocardial regeneration after infarction via enhanced cardiac C-kit+ cell proliferation and differentiation.Limana, F; Germani, A; Zacheo, A; Kajstura, J; Di Carlo, A; Borsellino, G; Leoni, O; Palumbo, R; Battistini, L; Rastaldo, R; Müller, S; Pompilio, G; Anversa, P; Bianchi, ME; Capogrossi, MC; 97:e73-e83Circulation Research10.1161/01.RES.0000186276.06104.0414.10.2005
16199040Structural basis for recognition of ubiquitinated cargo by Tom1-GAT domain.Akutsu M, Kawasaki M, Katoh Y, Shiba T, Yamaguchi Y, Kato R, Kato K, Nakayama K, Wakatsuki S.579(24):5385-91FEBS Lett10.1016/j.febslet.2005.08.07610.10.2005
16143108Identification of an intestinal heme transporter.Shayeghi, M; Latunde-Dada, GO; Oakhill, JS; Laftah, AH; Takeuchi, K; Halliday, N; Khan, Y; Warley, A; McCann, FE; Hider, RC; Frazer, DM; Anderson, GJ; Vulpe, CD; Simpson, RJ; McKie, AT; 122:789-801Cell10.1016/j.cell.2005.06.02501.9.2005
Human farnesyl diphosphate synthase (FDFS): Crystal structure and molecular interactions with Nnitrogen-containing bisphosphonates.Kavanagh, K; Guo, K; Wu, X; Knapp, S; Ebetino, FH; Dunford, JE; Rogers, MJ; Russell, RGG; Oppermann, U; 20:S95-S96Journal of Bone and Mineral Research01.9.2005
16001984Sodium channel Nav1.8 immunoreactivity in painful human dental pulp.Renton, T; Yiangou, Y; Plumpton, C; Tate, S; Bountra, C; Anand, P; 5:5-BMC Oral Health10.1186/1472-6831-5-57.7.2005
15840912Two-wavelength MAD phasing and radiation damage: a case study.González, A; von Delft, F; Liddington, RC; Bakolitsa, C; 12:285-291Journal of Synchrotron Radiation10.1107/S090904950500324901.5.2005
15777864Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain.Chessell, IP; Hatcher, JP; Bountra, C; Michel, AD; Hughes, JP; Green, P; Egerton, J; Murfin, M; Richardson, J; Peck, WL; Grahames, CBA; Casula, MA; Yiangou, Y; Birch, R; Anand, P; Buell, GN; 114:386-396PAIN10.1016/j.pain.2005.01.00201.4.2005
15755319Increased capsaicin receptor TRPV1 in skin nerve fibres and related vanilloid receptors TRPV3 and TRPV4 in keratinocytes in human breast pain.Gopinath, P; Wan, E; Holdcroft, A; Facer, P; Davis, JB; Smith, GD; Bountra, C; Anand, P; 5:2-BMC Women's Health10.1186/1472-6874-5-28.3.2005
The structural genomics consortium: High-output structure determinationGileadi, O; Colebrook, S; Burgess, N; Berridge, G; Haroniti, A; Shrestha, B; Smee, C; Sundstrom, M; 19:A315-A315FASEB Journal4.3.2005
15572651The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] is effective in animal models of neuropathic pain and central sensitization.Bingham, S; Beswick, PJ; Bountra, C; Brown, T; Campbell, IB; Chessell, IP; Clayton, N; Collins, SD; Davey, PT; Goodland, H; Gray, N; Haslam, C; Hatcher, JP; Hunter, AJ; Lucas, F; Murkitt, G; Naylor, A; Pickup, E; Sargent, B; Summerfield, SG; Stevens, A; Stratton, SC; Wiseman, J; 312:1161-1169Journal of Pharmacology and Experimental Therapeutics10.1124/jpet.104.07526701.3.2005
15713419Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction.Hardcastle, IR; Ahmed, SU; Atkins, H; Calvert, AH; Curtin, NJ; Farnie, G; Golding, BT; Griffin, RJ; Guyenne, S; Hutton, C; Källblad, P; Kemp, SJ; Kitching, MS; Newell, DR; Norbedo, S; Northen, JS; Reid, RJ; Saravanan, K; Willems, HMG; Lunec, J; 15:1515-1520Bioorganic and Medicinal Chemistry Letters10.1016/j.bmcl.2004.12.06101.3.2005
15657930Crystal structure of an alanine-glyoxylate aminotransferase from Anabaena sp. at 1.70 A resolution reveals a noncovalently linked PLP cofactor.Han, GW; Schwarzenbacher, R; Page, R; Jaroszewski, L; Abdubek, P; Ambing, E; Biorac, T; Canaves, JM; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Godzik, A; Grittini, C; Grzechnik, SK; Hale, J; Hampton, E; Haugen, J; Hornsby, M; Klock, HE; Koesema, E; Kreusch, A; Kuhn, P; Lesley, SA; Levin, I; McMullan, D; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Nigoghossian, E; Ouyang, J; Paulsen, J; Quijano, K; Reyes, R; Sims, E; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; von Delft, F; Wang, X; West, B; White, A; Wolf, G; Xu, Q; Zagnitko, O; Hodgson, KO; Wooley, J; Wilson, IA; 58:971-975Proteins10.1002/prot.203601.3.2005
15651027Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 2.80 A resolution reveals a new fold.Xu, Q; Schwarzenbacher, R; McMullan, D; Abdubek, P; Ambing, E; Biorac, T; Canaves, JM; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Hornsby, M; Jaroszewski, L; Klock, HE; Koesema, E; Kreusch, A; Kuhn, P; Lesley, SA; Levin, I; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Reyes, R; Robb, A; Sims, E; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; von Delft, F; Wang, X; West, B; White, A; Wolf, G; Zagnitko, O; Hodgson, KO; Wooley, J; Wilson, IA; 58:976-981Proteins10.1002/prot.203641.3.2005
15697201Crystal structure and solution NMR dynamics of a D (type II) peroxiredoxin glutaredoxin and thioredoxin dependent: a new insight into the peroxiredoxin oligomerism.Echalier, A; Trivelli, X; Corbier, C; Rouhier, N; Walker, O; Tsan, P; Jacquot, J-P; Aubry, A; Krimm, I; Lancelin, J-M; 44:1755-1767Biochemistry10.1021/bi048226s01.2.2005
15624212Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 A resolution.Arndt, JW; Schwarzenbacher, R; Page, R; Abdubek, P; Ambing, E; Biorac, T; Canaves, JM; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Godzik, A; Grittini, C; Grzechnik, SK; Hale, J; Hampton, E; Han, GW; Haugen, J; Hornsby, M; Klock, HE; Koesema, E; Kreusch, A; Kuhn, P; Jaroszewski, L; Lesley, SA; Levin, I; McMullan, D; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Nigoghossian, E; Ouyang, J; Peti, WS; Quijano, K; Reyes, R; Sims, E; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; von Delft, F; Wang, X; West, B; White, A; Wolf, G; Xu, Q; Zagnitko, O; Hodgson, KO; Wooley, J; Wilson, IA; 58:755-758Proteins10.1002/prot.2033615.2.2005
15542590The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions.Ogg, D; Elleby, B; Norström, C; Stefansson, K; Abrahmsén, L; Oppermann, U; Svensson, S; 280:3789-3794Journal of Biological Chemistry10.1074/jbc.M4124632004.2.2005
Erratum.Wang, H; McCann, FE; Gordan, JD; Wu, X; Moon, E-Y; Raab, M; Malik, TH; Davis, DM; Rudd, CE; 201:659-659Journal of Experimental Medicine10.1084/jem.20040780020805c01.2.2005
15352873X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster.Elkins, JM; Kershaw, NJ; Schofield, CJ; 385:565-573Biochemical Journal10.1042/BJ2004081415.1.2005
16245927Regulation of the wild-type and Y1235D mutant met kinase activationCristiani, C; Rusconi, L; Perego, R; Schiering, N; Kalisz, HM; Knapp, S; Isacchi, A; 44:14110-14119Biochemistry10.1021/bi051242k1.11.2005
Probing the access of protons to the K pathway in the Paracoccus denitrificans cytochrome c oxidaseRichter, O-MH; Dürr, KL; Kannt, A; Ludwig, B; Scandurra, FM; Giuffrè, A; Sarti, P; Hellwig, P; 272:404-412European Journal of Biochemistry10.1111/j.1742-4658.2004.04480.x01.1.2005
An electronically tunable ultrafast laser source applied to fluorescence imaging and fluorescence lifetime imaging microscopyLanigan, PMP; Dunsby, C; McGinty, J; Elson, DS; Requejo-Isidro, J; Munro, I; Galletly, N; Treanor, B; Onfelt, B; McCann, F; Davis, DM; Neil, MAA; French, PMW; IEEE, ; :1366-1368Optics InfoBase Conference Papers01.01.2005
An electronically tunable ultrafast laser source applied to fluorescence imaging and microscopy including fluorescence lifetime imagingDunsby, C; Lanigan, PMP; McGinty, J; De Beule, PAA; Auksorius, E; Schimpf, DN; Elson, DS; Requejo-Isidro, J; Munro, I; Galletly, N; Treanor, B; Önfelt, B; McCann, F; Davis, DM; Neil, MAA; French, PMW; :-10.1109/CLEOE.2005.15683951.12.2005
An electronically tunable ultrafast laser source applied to fluorescence imaging and fluorescence lifetime imaging microscopyDunsby, C; Lanigan, PMP; McGinty, J; Elson, DS; Requejo-Isidro, J; Munro, I; Galletly, N; McCann, F; Treanor, B; Onfelt, B; Davis, DM; Neil, MAA; French, PMW; 37:3296-3303Journal of Physics D: Applied Physics10.1088/0022-3727/37/23/0117.12.2004
15572112Coupling PAF signaling to dynein regulation: Structure of LIS1 in complex with PAF-acetylhydrolaseTarricone, C; Perrina, F; Monzani, S; Massimiliano, L; Kim, MH; Derewenda, ZS; Knapp, S; Tsai, LH; Musacchio, A; 44:809-821Neuron10.1016/j.neuron.2004.11.0192.12.2004
15494152nNOS expression following inferior alveolar nerve injury in the ferret.Davies, SL; Loescher, AR; Clayton, NM; Bountra, C; Robinson, PP; Boissonade, FM; 1027:11-17Brain Research10.1016/j.brainres.2004.08.06219.11.2004
15454242Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors.Beswick, P; Bingham, S; Bountra, C; Brown, T; Browning, K; Campbell, I; Chessell, I; Clayton, N; Collins, S; Corfield, J; Guntrip, S; Haslam, C; Lambeth, P; Lucas, F; Mathews, N; Murkit, G; Naylor, A; Pegg, N; Pickup, E; Player, H; Price, H; Stevens, A; Stratton, S; Wiseman, J; 14:5445-5448Bioorganic and Medicinal Chemistry Letters10.1016/j.bmcl.2004.07.0891.11.2004
Membrane nanotubes network immune cellsDavis, DM; Onfelt, B; Nedvetzki, S; Vanherberghen, B; McCann, FE; Carlin, LM; Taner, SB; Eleme, K; Treanor, B; de Almeida, C; Williams, G; Nolte, E; Hoen, T; Yanagi, K; 15:6A-6AMolecular Biology of the Cell01.11.2004
15477347ADAP-SLP-76 binding differentially regulates supramolecular activation cluster (SMAC) formation relative to T cell-APC conjugation.Wang, H; McCann, FE; Gordan, JD; Wu, X; Raab, M; Malik, TH; Davis, DM; Rudd, CE; 200:1063-1074Journal of Experimental Medicine10.1084/jem.2004078011.10.2004
15087320SAD--a normalized structural alignment database: improving sequence-structure alignments.Marsden, B; Abagyan, R; 20:2333-2344Bioinformatics10.1093/bioinformatics/bth24401.10.2004
15458401Recognition of iron-free siderophores by TonB-dependent iron transporters.Schalk, IJ; Yue, WW; Buchanan, SK; 54:14-22Molecular Microbiology10.1111/j.1365-2958.2004.04241.x01.10.2004
15464211Allodynia in rats infected with varicella zoster virus--a small animal model for post-herpetic neuralgia.Dalziel, RG; Bingham, S; Sutton, D; Grant, D; Champion, JM; Dennis, SA; Quinn, JP; Bountra, C; Mark, MA; 46:234-242Brain Research Reviews10.1016/j.brainresrev.2004.07.00801.10.2004
Increased sodium channel Na(v)1.8 immunoreactivity in painful human dental pulpRenton, T; Yiangou, Y; Plumpton, C; Tate, S; Bountra, C; Anand, P; 59:1040-1041Anaesthesia01.10.2004
15326606Crystal structure of a tandem cystathionine-beta-synthase (CBS) domain protein (TM0935) from Thermotoga maritima at 1.87 A resolution.Miller, MD; Schwarzenbacher, R; von Delft, F; Abdubek, P; Ambing, E; Biorac, T; Brinen, LS; Canaves, JM; Cambell, J; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Eshagi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Jaroszewski, L; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; Levin, I; McMullan, D; McPhillips, TM; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Robb, A; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Wilson, IA; 57:213-217Proteins10.1002/prot.200241.10.2004
15379539The long acidic tail of high mobility group box 1 (HMGB1) protein forms an extended and flexible structure that interacts with specific residues within and between the HMG boxes.Knapp, S; Müller, S; Digilio, G; Bonaldi, T; Bianchi, ME; Musco, G; 43:11992-11997Biochemistry10.1021/bi049364k28.9.2004
15296490Control of immune responses by trafficking cell surface proteins, vesicles and lipid rafts to and from the immunological synapse.Taner, SB; Onfelt, B; Pirinen, NJ; McCann, FE; Magee, AI; Davis, DM; 5:651-661Traffic10.1111/j.1600-0854.2004.00214.x01.9.2004
15229897Crystal structure of a putative NADPH-dependent oxidoreductase (GI: 18204011) from mouse at 2.10 A resolution.Levin, I; Schwarzenbacher, R; McMullan, D; Abdubek, P; Ambing, E; Biorac, T; Cambell, J; Canaves, JM; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Jaroszewski, L; Karlak, C; Klock, HE; Koesema, E; Kreusch, A; Kuhn, P; Lesley, SA; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Reyes, R; Robb, A; Sims, E; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; von Delft, F; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Wilson, IA; 56:629-633Proteins10.1002/prot.2016315.8.2004
15229895Crystal structure of an allantoicase (YIR029W) from Saccharomyces cerevisiae at 2.4 A resolution.Xu, Q; Schwarzenbacher, R; Page, R; Sims, E; Abdubek, P; Ambing, E; Biorac, T; Brinen, LS; Cambell, J; Canaves, JM; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Jaroszewski, L; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; Levin, I; McMullan, D; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Quijano, K; Reyes, R; Rezezadeh, F; Robb, A; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; von Delft, F; Wang, X; West, B; Wolf, G; Hodgson, KO; Wooley, J; Wilson, IA; 56:619-624Proteins10.1002/prot.2016415.8.2004
15229894Crystal structure of a novel Thermotoga maritima enzyme (TM1112) from the cupin family at 1.83 A resolution.McMullan, D; Schwarzenbacher, R; Jaroszewski, L; von Delft, F; Klock, HE; Vincent, J; Quijano, K; Abdubek, P; Ambing, E; Biorac, T; Brinen, LS; Canaves, JM; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Eshaghi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Karlak, C; Koesema, E; Kreusch, A; Kuhn, P; Levin, I; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Reyes, R; Rezezadeh, F; Robb, A; Sims, E; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Lesley, SA; Wilson, IA; 56:615-618Proteins10.1002/prot.2013915.8.2004
15229893Crystal structure of a novel manganese-containing cupin (TM1459) from Thermotoga maritima at 1.65 A resolution.Jaroszewski, L; Schwarzenbacher, R; von Delft, F; McMullan, D; Brinen, LS; Canaves, JM; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Eshagi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Levin, I; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Reyes, R; Rezezadeh, F; Robb, A; Sims, E; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Wilson, IA; 56:611-614Proteins10.1002/prot.2013015.8.2004
15229892Crystal structure of an orphan protein (TM0875) from Thermotoga maritima at 2.00-A resolution reveals a new fold.Bakolitsa, C; Schwarzenbacher, R; McMullan, D; Brinen, LS; Canaves, JM; Dai, X; Deacon, AM; Elsliger, M-A; Eshagi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Jaroszewski, L; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Robb, A; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; von Delft, F; Wang, X; West, B; Wolf, G; Hodgson, KO; Wooley, J; Wilson, IA; 56:607-610Proteins10.1002/prot.2013815.8.2004
15180984Tic32, an essential component in chloroplast biogenesis.Hörmann, F; Küchler, M; Sveshnikov, D; Oppermann, U; Li, Y; Soll, J; 279:34756-34762Journal of Biological Chemistry10.1074/jbc.M40281720013.8.2004
15173166The structure and dynamics of tandem WW domains in a negative regulator of notch signaling, Suppressor of deltex.Fedoroff, OY; Townson, SA; Golovanov, AP; Baron, M; Avis, JM; 279:34991-35000Journal of Biological Chemistry10.1074/jbc.m40498720001.8.2004
15292509Direct observation of RuvAB-catalyzed branch migration of single Holliday junctions.Amit, R; Gileadi, O; Stavans, J; 101:11605-11610Proceedings of the National Academy of Sciences10.1073/pnas.040433210110.8.2004
15262229High-level production and optimization of monodispersity of 11beta-hydroxysteroid dehydrogenase type 1.Elleby, B; Svensson, S; Wu, X; Stefansson, K; Nilsson, J; Hallén, D; Oppermann, U; Abrahmsén, L; 1700:199-207BBA - Biochimica et Biophysica Acta10.1016/j.bbapap.2004.05.0032.8.2004
15272298HMGB1 is an endogenous immune adjuvant released by necrotic cells.Rovere-Querini, P; Capobianco, A; Scaffidi, P; Valentinis, B; Catalanotti, F; Giazzon, M; Dumitriu, IE; Müller, S; Iannacone, M; Traversari, C; Bianchi, ME; Manfredi, AA; 5:825-830EMBO Reports10.1038/sj.embor.740020501.8.2004
Crystal structure and biophysical characterization of human GDP-D-mannose 4, 6-dehydrataseVedadi, M; Walker, JR; Sharma, S; Houston, SA; Wasney, GA; Loppnau, P; Oppermann, U; 13:81-82Protein Science01.8.2004
15211526Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 A resolution.Levin, I; Schwarzenbacher, R; Page, R; Abdubek, P; Ambing, E; Biorac, T; Brinen, LS; Campbell, J; Canaves, JM; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Jaroszewski, L; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; McMullan, D; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Quijano, K; Reyes, R; Rezezadeh, F; Robb, A; Sims, E; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; von Delft, F; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Wilson, IA; 56:404-408Proteins10.1002/prot.200901.8.2004
From crystals to pdb: building a high throughput crystallography pipeline for strucural genomicsChiu, H; Wolf, G; West, W; van den Bedem, H; Miller, MD; Zhang, Z; Morse, A; von Delft, F; Elsliger, MA; Grzechnik, SK; 13:184-184Protein Science01.8.2004
15211524Crystal structure of a methionine aminopeptidase (TM1478) from Thermotoga maritima at 1.9 A resolution.Spraggon, G; Schwarzenbacher, R; Kreusch, A; McMullan, D; Brinen, LS; Canaves, JM; Dai, X; Deacon, AM; Elsliger, M-A; Eshagi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Jaroszewski, L; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kuhn, P; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Rezezadeh, F; Robb, A; Sims, E; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; von Delft, F; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Lesley, SA; Wilson, IA; 56:396-400Proteins10.1002/prot.200841.8.2004
15211523Crystal structure of a putative oxalate decarboxylase (TM1287) from Thermotoga maritima at 1.95 A resolution.Schwarzenbacher, R; von Delft, F; Jaroszewski, L; Abdubek, P; Ambing, E; Biorac, T; Brinen, LS; Canaves, JM; Cambell, J; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Eshagi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; Levin, I; McMullan, D; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Robb, A; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Wilson, IA; 56:392-395Proteins10.1002/prot.200161.8.2004
15211522Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 A resolution.Heine, A; Canaves, JM; von Delft, F; Brinen, LS; Dai, X; Deacon, AM; Elsliger, MA; Eshaghi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Guda, C; Jaroszewski, L; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; McMullan, D; McPhillips, TM; Miller, MA; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Robb, A; Rodrigues, K; Schwarzenbacher, R; Selby, TL; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; Wang, X; West, B; Wolf, G; Hodgson, KO; Wooley, J; Wilson, IA; 56:387-391Proteins10.1002/prot.200031.8.2004
Increase of purinergic receptor P2X(7) in injured human nerves and dorsal root gangliaCasula, MA; Chessell, IP; Bountra, C; Yiangou, Y; Birch, R; Anand, P; 75:1227-1227Journal of Neurology, Neurosurgery and Psychiatry01.8.2004
Increased cyclooxygenase-2 (Cox-2) expression by macrophages in chronic but not acute nerve injury in humans and rodentsDurrenberger, PF; Facer, P; Gray, RA; Chessell, IP; Naylor, A; Bountra, C; Banati, RB; Elliot, D; Anand, P; 75:1228-1228Journal of Neurology, Neurosurgery and Psychiatry01.8.2004
15330095Membrane protein isolation by in situ solubilization, partitioning and affinity adsorption in aqueous two-phase systems. Purification of the human type 1 11beta-hydroxysteroid dehydrogenase.Roobol-Bóza, M; Dolby, V; Doverskog, M; Barrefelt, A; Lindqvist, F; Oppermann, UC; Köhler Van Alstine, K; Tjerneld, F; 1043:217-223Journal of Chromatography A23.7.2004
15232296Expression of the sodium channel beta3 subunit in injured human sensory neurons.Casula, MA; Facer, P; Powell, AJ; Kinghorn, IJ; Plumpton, C; Tate, SN; Bountra, C; Birch, R; Anand, P; 15:1629-1632NeuroReport19.7.2004
15162497Crystal structure of a ribose-5-phosphate isomerase RpiB (TM1080) from Thermotoga maritima at 1.90 A resolution.Xu, Q; Schwarzenbacher, R; McMullan, D; von Delft, F; Brinen, LS; Canaves, JM; Dai, X; Deacon, AM; Elsliger, M-A; Eshagi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Jaroszewski, L; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; Levin, I; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Robb, A; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; Wang, X; West, B; Wolf, G; Hodgson, KO; Wooley, J; Wilson, IA; 56:171-175Proteins10.1002/prot.201291.7.2004
15162496Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 1.60 A resolution.Santelli, E; Schwarzenbacher, R; McMullan, D; Biorac, T; Brinen, LS; Canaves, JM; Cambell, J; Dai, X; Deacon, AM; Elsliger, M-A; Eshagi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Jaroszewski, L; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Rezezadeh, F; Robb, A; Sims, E; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; von Delft, F; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Wilson, IA; 56:167-170Proteins10.1002/prot.201201.7.2004
15146505Crystal structure of an Udp-n-acetylmuramate-alanine ligase MurC (TM0231) from Thermotoga maritima at 2.3 A resolution.Spraggon, G; Schwarzenbacher, R; Kreusch, A; Lee, CC; Abdubek, P; Ambing, E; Biorac, T; Brinen, LS; Canaves, JM; Cambell, J; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Eshagi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Jaroszewski, L; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kuhn, P; Levin, I; McMullan, D; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Robb, A; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; von Delft, F; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Lesley, SA; Wilson, IA; 55:1078-1081Proteins10.1002/prot.200341.6.2004
15103640Crystal structure of a type II quinolic acid phosphoribosyltransferase (TM1645) from Thermotoga maritima at 2.50 A resolution.Schwarzenbacher, R; Jaroszewski, L; von Delft, F; Abdubek, P; Ambing, E; Biorac, T; Brinen, LS; Canaves, JM; Cambell, J; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Eshagi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; Levin, I; McMullan, D; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Robb, A; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Wilson, IA; 55:768-771Proteins10.1002/prot.2002915.5.2004
15103638Crystal structure of an aspartate aminotransferase (TM1255) from Thermotoga maritima at 1.90 A resolution.Schwarzenbacher, R; Jaroszewski, L; von Delft, F; Abdubek, P; Ambing, E; Biorac, T; Brinen, LS; Canaves, JM; Cambell, J; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Eshagi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; Levin, I; McMullan, D; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Robb, A; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Wilson, IA; 55:759-763Proteins10.1002/prot.1064615.5.2004
15204979Electron microscopy of wet tissues: a case study in renal pathology.Nyska, A; Cummings, CA; Vainshtein, A; Nadler, J; Ezov, N; Grunfeld, Y; Gileadi, O; Behar, V; 32:357-363Toxicologic Pathology10.1080/0192623049043177201.5.2004
Fat cell precursors from different human fat depots are distinct: Morphological and gene expression profilesKirkland, J; Tchkonia, T; Frampton, G; Lenberg, M; Giorgadze, N; Sabban, A; Pirtskhalava, T; Cartwright, M; Gerry, N; Forse, A; Thomou, T; Gileadi, O; 28:S99-S99International Journal of Obesity01.5.2004
15048837Crystal structure of a phosphoribosylaminoimidazole mutase PurE (TM0446) from Thermotoga maritima at 1.77-A resolution.Schwarzenbacher, R; Jaroszewski, L; von Delft, F; Abdubek, P; Ambing, E; Biorac, T; Brinen, LS; Canaves, JM; Cambell, J; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Eshagi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; Levin, I; McMullan, D; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Robb, A; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Wilson, IA; 55:474-478Proteins10.1002/prot.200231.5.2004
15051759Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D.Eleme, K; Taner, SB; Onfelt, B; Collinson, LM; McCann, FE; Chalupny, NJ; Cosman, D; Hopkins, C; Magee, AI; Davis, DM; 199:1005-1010Journal of Experimental Medicine10.1084/jem.2003219401.4.2004
15039538Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner.Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H.85(Pt 4):959-69J Gen Virol10.1099/vir.0.19513-001.04.2004
29899950Non-competitive cyclic peptides for targeting enzyme–substrate complexesMcallister, TE; Yeh, T-L; Abboud, ; Leung, IKH; Hookway, ES; King, ONF; Bhushan, B; Williams, ST; Hopkinson, RJ; Muenzel, M; Loik, ND; Chowdhury, R; Oppermann, U; Claridge, TDW; Goto, Y; Suga, H; Schofield, CJ; Kawamura, A; :-Chemical Science10.1039/c8sc00286j01.01.
Measuring Cation Transport by Na,K- and H,K-ATPase in <em>Xenopus</em> Oocytes by Atomic Absorption Spectrophotometry: An Alternative to Radioisotope AssaysDürr, KL; Tavraz, NN; Spiller, S; Friedrich, T; :-Journal of Visualized Experiments10.3791/5020101.01.
Control of Gastric H,K-ATPase Activity by Cations, Voltage and Intracellular pH Analyzed by Voltage Clamp Fluorometry in Xenopus OocytesDürr, KL; Tavraz, NN; Friedrich, T; 7:e33645-e33645PLoS ONE10.1371/journal.pone.003364501.01.