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- Masoud Vedadi
Molecular Biophysics - Stefan Knapp
Epigenetics & Chemical Biology - Oleg Fedorov
Biophysics/Biochemical Screening - Panagis Filippakopoulos
Bromodomains
In the Biophysics group we focus on developing new high throughput biophysical and biochemical characterization and screening methods.
We are particularly interested in employing these methods in developing chemical probes for epigenetic targets.
By screening proteins against customized chemical libraries, we identify small molecules that inhibit / bind to these proteins that could be used in developing chemical probes for epigenetic targets in collaboration with chemistry partners and other SGC groups.
In creating and comparing chemical profiles for members of each protein family along with functional studies, we investigate structure-function relationship and identify unique inhibitors that can discriminate among members of each protein family.
Protocols
The SGC uses a great many protocols, some of which are made available below.
Small molecule Screening protocols
- click to view/download a PDF containing information from a Small Molecule Screening Workshop delivered by the SGC.