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A public-private partnership that supports the discovery of new medicines through open access research.
SGC-UBD1031 A probe with dual USP16-HDAC6 activity.The probe and control may be requested here. For any inquiries please contact proberequests@thesgc.org.group newOverviewSGC in collaboration with Dr Mark Lautens’ at the University of Toronto’s Department of Chemistry has developed the first chemical probe SGC-UBD1031 for the ubiquitin binding domain (UBD) of USP16. SGC-UBD1031 has equipotent affinity to HDAC6 UBD and it is recommended to be used in parallel with SGC-UBD253. SGC-UBD1031 binds potently USP16 UBD with KD = 16 nM (SPR), and in cells it inhibits the USP16-ISG15 interaction with EC50 = 1.5 micromolar (nanoBRET). SGC-UBD1031N is a closely related negative control with no activity in the nanoBRET assay up to 30 micromolar. Selectivity Profile In Vitro Potency Cell-based Assay Data