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Susanne Müller-Knapp studied Human Biology in Marburg Germany followed by a PhD in molecular biology at the Karolinska Institute in Stockholm, Sweden (1997). She then had more than 6 years of postdoctoral training in the area of inflammation and gene regulation at the Karolinska Institute and at the DIBIT San Raffaele Scientific Institute in Milan, Italy.
In 2004 Susanne joined the Structural Genomics Consortium, SGC, in Oxford. The SGC is an international public private partnership that currently comprises 8 international pharmaceutical companies and a large network of academic and industrial collaborators. Susanne worked at the SGC first as External Research Manager and then Scientific Coordinator. She has been the Project Manager of the Epigenetic Probe Project, which generates tool compounds with defined specificity and selectivity for epigenetic targets and the cell based assay group at the SGC in Oxford testing the cellular activity of the in vitro characterised tool compounds. In her role as Chief Operating Officer at the SGC Frankfurt Susanne is now coordinating several probe programs including the global SGC kinase chemical probe program and the donated probe program, which makes probes available from the pharmaceutical partners of the SGC. She is also Director of Operations of the Chemical Probes Portal, an online platform, providing e recommendations for the right choice and use of chemical probes https://www.chemicalprobes.org/.
The Cellular assay group establishes cellular model systems to establish the efficacy of the developed inhibitors and then further uses them to increase the knowledge of the biological function of the targeted proteins as well as validate their role in disease as a target for pharmacological intervention.
Cell Chem Biol. 2023 . doi: 10.1016/j.chembiol.2023.09.003
PMID: 37797617
ACS Chem Biol. 2023 . doi: 10.1021/acschembio.2c00877
PMID: 36944371
Oncotarget. 2020 11(5):535-549. doi: 10.18632/oncotarget.27462
PMID: 32082487
Nat Commun. 2019 10(1):1915. doi: 10.1038/s41467-019-09672-2
PMID: 31015424
Elife. 2018 7:. doi: 10.7554/eLife.34311
PMID: 29676732
Nat Commun. 2017 8:14773. doi: 10.1038/ncomms14773
PMID: 28382930
Epigenetics Chromatin. 2017 10:9. doi: 10.1186/s13072-017-0116-6
PMID: 28265301
Oncogene. 2016 35:4423-4436. doi: 10.1038/onc.2015.513
PMID: 26804164
Sci Adv. 2015 1(10):e1500723. doi: 10.1126/sciadv.1500723
PMID: 26702435
Epigenetics Chromatin. 2014 7:14. doi: 10.1186/1756-8935-7-14
PMID: 25097667
2024
Nat Protoc. 18.04.2024 . doi: 10.1038/s41596-024-00979-z
PMID: 38637703
J Med Chem. 29.02.2024 . doi: 10.1021/acs.jmedchem.3c02217
PMID: 38422480
Adv Sci (Weinh). 13.02.2024 e2307237. doi: 10.1002/advs.202307237
PMID: 38350720
2023
ACS Chem Biol. 21.03.2023 . doi: 10.1021/acschembio.2c00877
PMID: 36944371
2022
STAR Protoc. 16.12.2022 3(4):101791. doi: 10.1016/j.xpro.2022.101791
PMID: 36317177
RSC Med Chem. 14.12.2022 13(12):1438. doi: 10.1039/d2md90036j
PMID: 36561071
J Med Chem. 14.12.2022 . doi: 10.1021/acs.jmedchem.2c01705
PMID: 36516476
Int J Mol Sci. 27.11.2022 23(23):. doi: 10.3390/ijms232314834
PMID: 36499165
Nucleic Acids Res. 21.10.2022 . doi: 10.1093/nar/gkac909
PMID: 36268860
Int J Mol Sci. 07.10.2022 23(19):. doi: 10.3390/ijms231911911
PMID: 36233212
Chembiochem. 29.09.2022 e202200373. doi: 10.1002/cbic.202200373
PMID: 36173930
J Med Chem. 22.09.2022 . doi: 10.1021/acs.jmedchem.2c01106
PMID: 36136092
Chem Soc Rev. 25.08.2022 . doi: 10.1039/d2cs00478j
PMID: 36004812
Biochem Pharmacol. 27.07.2022 204:115191. doi: 10.1016/j.bcp.2022.115191
PMID: 35907497
Front Cell Dev Biol. 21.06.2022 10:886537. doi: 10.3389/fcell.2022.886537
PMID: 35721509
J Med Chem. 24.05.2022 . doi: 10.1021/acs.jmedchem.2c00173
PMID: 35608370
Molecules. 21.02.2022 27(4):. doi: 10.3390/molecules27041439
PMID: 35209227
RSC Med Chem. 27.01.2022 13(1):13-21. doi: 10.1039/d1md00228g
PMID: 35211674
2021
Drug Discov Today. 30.10.2021 . doi: 10.1016/j.drudis.2021.10.021
PMID: 34728376
J Med Chem. 20.09.2021 . doi: 10.1021/acs.jmedchem.1c00845
PMID: 34543009
J Med Chem. 10.09.2021 . doi: 10.1021/acs.jmedchem.1c00868
PMID: 34506142
Biochem J. 30.06.2021 . doi: 10.1042/BCJ20210257
PMID: 34190988
FASEB J. 28.05.2021 35(6):e21656. doi: 10.1096/fj.202100037R
PMID: 34042211
Cell Chem Biol. 21.01.2021 . doi: 10.1016/j.chembiol.2021.01.003
PMID: 33497606
Cell Chem Biol. 11.01.2021 . doi: 10.1016/j.chembiol.2020.12.013
PMID: 33484635
Int J Mol Sci. 08.01.2021 22(2):. doi: 10.3390/ijms22020566
PMID: 33429995
2020
Front Oncol. 17.11.2020 10:591843. doi: 10.3389/fonc.2020.591843
PMID: 33194754
SLAS Discov. 27.05.2020 2472555220923979. doi: 10.1177/2472555220923979
PMID: 32458721
Oncogene. 04.05.2020 . doi: 10.1038/s41388-020-1301-9
PMID: 32366905
Annual Review of Biochemistry. 24.03.2020 89:557-581. doi: 10.1146/annurev-biochem-011420-092302
PMID: 32208767
ACS Chem. Biol.. 16.03.2020 . doi: 10.1021/acschembio.0c00076
PMID: 32176847
Oncotarget. 04.02.2020 11(5):535-549. doi: 10.18632/oncotarget.27462
PMID: 32082487
Nat Commun. 21.01.2020 11(1):419. doi: 10.1038/s41467-020-14299-9
PMID: 31964889
Endocr. Relat. Cancer. 01.01.2020 . doi: 10.1530/ERC-19-0448
PMID: 31935194
2019
Sci Rep. 22.11.2019 9(1):17363. doi: 10.1038/s41598-019-53915-7
PMID: 31758045
Nat Commun. 23.04.2019 10(1):1915. doi: 10.1038/s41467-019-09672-2
PMID: 31015424
J. Med. Chem.. 15.02.2019 . doi: 10.1021/acs.jmedchem.8b01213
PMID: 30768268
Cell Rep. 02.01.2019 26(1):79-93.e8. doi: 10.1016/j.celrep.2018.12.023
PMID: 30605688
2018
ChemMedChem. 20.08.2018 13(16):1629-1633. doi: 10.1002/cmdc.201800398
PMID: 29928781
J. Med. Chem.. 31.05.2018 . doi: 10.1021/acs.jmedchem.8b00571
PMID: 29852068
Elife. 20.04.2018 7:. doi: 10.7554/eLife.34311
PMID: 29676732
2017
Cell Chem Biol. 13.11.2017 . doi: 10.1016/j.chembiol.2017.10.010
PMID: 29174542
Angew. Chem. Int. Ed. Engl.. 04.10.2017 . doi: 10.1002/anie.201706788
PMID: 28976073
ACS Chem. Biol.. 29.08.2017 . doi: 10.1021/acschembio.7b00481
PMID: 28849908
PLoS ONE. 03.08.2017 12(8):e0181585. doi: 10.1371/journal.pone.0181585
PMID: 28767711
J. Med. Chem.. 17.07.2017 . doi: 10.1021/acs.jmedchem.7b00611
PMID: 28714688
Methods Mol. Biol.. 05.05.2017 1586:337-344. doi: 10.1007/978-1-4939-6887-9_22
PMID: 28470616
J. Med. Chem.. 12.04.2017 . doi: 10.1021/acs.jmedchem.7b00306
PMID: 28402630
Nat Commun. 06.04.2017 8:14773. doi: 10.1038/ncomms14773
PMID: 28382930
Epigenetics Chromatin. 08.03.2017 10:9. doi: 10.1186/s13072-017-0116-6
PMID: 28265301
Cell Chem Biol. 27.02.2017 . doi: 10.1016/j.chembiol.2017.02.006
PMID: 28262558
Epigenetics. 12.01.2017 0. doi: 10.1080/15592294.2017.1279371
PMID: 28080202
J. Med. Chem.. 09.01.2017 . doi: 10.1021/acs.jmedchem.6b01583
PMID: 28068087
2016
Sci Adv. 21.10.2016 2(10):e1600760. doi: 10.1126/sciadv.1600760
PMID: 27757418
J. Med. Chem.. 27.09.2016 . doi: 10.1021/acs.jmedchem.6b00774
PMID: 27673482
J. Med. Chem.. 12.09.2016 . doi: 10.1021/acs.jmedchem.6b00355
PMID: 27617704
Protein Eng. Des. Sel.. 01.09.2016 . doi: 10.1093/protein/gzw042
PMID: 27590051
Oncotarget. 01.06.2016 . doi: 10.18632/oncotarget.9766
PMID: 27259267
ACS Chem. Biol.. 24.05.2016 . doi: 10.1021/acschembio.6b00286
PMID: 27219844
Nat. Chem. Biol.. 09.05.2016 . doi: 10.1038/nchembio.2080
PMID: 27159579
J. Med. Chem.. 27.04.2016 . doi: 10.1021/acs.jmedchem.5b01997
PMID: 27119626
J. Med. Chem.. 26.04.2016 . doi: 10.1021/acs.jmedchem.6b00012
PMID: 27115555
J. Med. Chem.. 25.02.2016 . doi: 10.1021/acs.jmedchem.5b01865
PMID: 26914985
Biomed Opt Express. 01.02.2016 7(2):422-41. doi: 10.1364/BOE.7.000422
PMID: 26977352
J. Med. Chem.. 07.01.2016 . doi: 10.1021/acs.jmedchem.5b01635
PMID: 26741168
J. Med. Chem.. 05.01.2016 . doi: 10.1021/acs.jmedchem.5b01719
PMID: 26731131
2015
Sci Adv. 13.11.2015 1(10):e1500723. doi: 10.1126/sciadv.1500723
PMID: 26702435
Cancer Res.. 09.11.2015 . doi: 10.1158/0008-5472.CAN-15-0236
PMID: 26552700
Nat. Biotechnol.. 26.10.2015 . doi: 10.1038/nbt.3374
PMID: 26501955
Nat. Chem. Biol.. 20.10.2015 11(11):818-21. doi: 10.1038/nchembio.1938
PMID: 26485069
Proc. Natl. Acad. Sci. U.S.A.. 10.08.2015 . doi: 10.1073/pnas.1501956112
PMID: 26261308
Nat. Chem. Biol.. 21.07.2015 11(8):536-41. doi: 10.1038/nchembio.1867
PMID: 26196764
J. Med. Chem.. 14.05.2015 . doi: 10.1021/acs.jmedchem.5b00458
PMID: 25974391
Angew. Chem. Int. Ed. Engl.. 13.04.2015 . doi: 10.1002/anie.201501394
PMID: 25864491
J. Med. Chem.. 23.03.2015 . doi: 10.1021/acs.jmedchem.5b00209
PMID: 25799074
J. Med. Chem.. 26.02.2015 . doi: 10.1021/jm501963e
PMID: 25719566
2014
Nat. Chem. Biol.. 18.07.2014 10(8):692. doi:
PMID: 25036311
Epigenetics Chromatin. 13.07.2014 7:14. doi: 10.1186/1756-8935-7-14
PMID: 25097667
J. Am. Chem. Soc.. 02.07.2014 136(26):9308-19. doi: 10.1021/ja412434f
PMID: 24946055
Angew. Chem. Int. Ed. Engl.. 12.05.2014 . doi: 10.1002/anie.201402750
PMID: 24821300
Nat. Chem. Biol.. 02.03.2014 10(4):305-12. doi: 10.1038/nchembio.1471
PMID: 24584101
Biochem. J.. 17.01.2014 . doi: 10.1042/BJ20131399
PMID: 24438162
2013
J. Med. Chem.. 08.12.2013 . doi: 10.1021/jm401568s
PMID: 24313754
Proc. Natl. Acad. Sci. U.S.A.. 18.11.2013 . doi: 10.1073/pnas.1310658110
PMID: 24248379
Chem Sci. 01.08.2013 4(8):3110-3117. doi: 10.1039/C3SC51122G
PMID: 26682036
Cancer Res.. 01.06.2013 73(11):3336-3346. doi: 10.1158/0008-5472.CAN-12-3292
PMID: 23576556
Clin. Cancer Res.. 26.03.2013 . doi: 10.1158/1078-0432.CCR-12-3066
PMID: 23403638
2012
J. Med. Chem.. 26.07.2012 55(14):6639-43. doi: 10.1021/jm300677j
PMID: 22724510
N Biotechnol. 15.06.2012 29(5):515-25. doi: 10.1016/j.nbt.2011.10.007
PMID: 22027370
Cell. 30.03.2012 149(1):214-31. doi: 10.1016/j.cell.2012.02.013
PMID: 22464331
2011
Expert Rev Mol Med. 22.09.2011 13:e29. doi: 10.1017/S1462399411001992
PMID: 21933453
J. Inherit. Metab. Dis.. 29.03.2011 34(3):671-6. doi: 10.1007/s10545-011-9294-8
PMID: 21445611
2010
Expert Opin Drug Discov. 15.07.2010 5(9):867-81. doi: 10.1517/17460441.2010.504203
PMID: 22823261
. 8 July 2010 :-. doi: US-2010172896-A1
PMID:
Nat. Chem. Biol.. 16.02.2010 6(3):166-169. doi: 10.1038/nchembio.297
PMID: 20154661
2009
Curr. Opin. Struct. Biol.. 18.11.2009 19(6):643-9. doi: 10.1016/j.sbi.2009.10.001
PMID: 19926274
Cell. 23.01.2009 136(2):352-63. doi: 10.1016/j.cell.2008.11.038
PMID: 19167335
2007
Proc. Natl. Acad. Sci. U.S.A.. 18.12.2007 104(51):20523-8. doi: 10.1073/pnas.0708800104
PMID: 18077363
Structure. 17.10.2007 15(10):1215-26. doi: 10.1016/j.str.2007.08.011
PMID: 17937911
J. Struct. Funct. Genomics. 12.10.2007 8(2-3):107-19. doi: 10.1007/s10969-007-9027-2
PMID: 17932789