(R)-9s |
ADRA1D |
GPCR |
Antagonist |
Yes |
(S)-9s |
|
|
(R)-ZINC-3573 |
MRGPRX2 |
GPCR |
Agonist |
No |
(S)-ZINC-3573 |
|
|
8RK64 |
UCHL1 |
Ubiquitin C‐terminal hydrolase |
Inhibitor |
Yes |
JYQ88 |
|
|
A-079 |
TRPA1 |
TRP channels |
Antagonist |
Yes |
A-226 |
|
|
A-1155463 |
BCL2L1 |
Bcl-2 family |
Inhibitor |
Yes |
A-1107969 |
|
|
A-1211212 |
BCL2 |
Bcl-2 family |
Inhibitor |
Yes |
A-1210227 |
|
|
A-1596586 |
CFTR |
ATP-Binding Cassette (ABC) |
Corrector |
Yes |
A-1596584 |
|
|
A-192621 |
EDNRB |
Endothelin receptor |
Antagonist |
Yes |
A-1806262 |
|
|
A-446 |
GLS |
Aminohydrolase |
Inhibitor |
Yes |
A-426 |
|
|
A-485 |
EP300, CREBBP |
HAT |
Inhibitor |
Yes |
A-486 |
|
|
ABT-100 |
FNTB |
Transferase |
Inhibitor |
Yes |
A-108 |
|
|
ABT-546 |
EDNRA |
Endothelin receptor |
Antagonist |
Yes |
A-545 |
|
|
ABT-724 |
DRD4 |
GPCR |
Agonist |
Yes |
A-769 |
|
|
BAY 1753011 |
AVPR1A, AVPR2 |
GPCR |
Antagonist |
Yes |
BAY-2297 |
|
|
BAY 1816032 |
BUB1 |
Kinase |
Inhibitor |
Yes |
BAY-283 |
|
|
BAY-069 |
BCAT1, BCAT2 |
Amino acid transaminase |
Inhibitor |
Yes |
BAY-771 |
|
|
BAY-091 |
PIP4K2A |
Kinase |
Inhibitor |
Yes |
BAY-0361 |
|
|
BAY-179 |
Complex I |
Complex of 42 peptides |
Inhibitor |
Yes |
BAY-070 |
|
|
BAY-1797 |
P2X4 |
P2RX4 |
Inhibitor |
Yes |
BAY-207 |
|
|
BAY-277 |
METAP2 |
Aminopeptidase |
Degrader |
Yes |
BAY-8805 |
|
|
BAY-293 |
SOS1 |
GEF |
Inhibitor |
No |
BAY-294 |
|
|
BAY-3153 |
CCR1 |
GPCR |
Antagonist |
Yes |
BAY-173 |
|
|
BAY-3827 |
PRKAA1, RPS6KA1 |
Kinase |
Inhibitor |
No |
BAY-974 |
|
|
BAY-386 |
F2R |
GPCR |
Antagonist |
Yes |
BAY-448 |
|
|
BAY-390 |
TRPA1 |
Ion channel |
Inhibitor |
Yes |
BAY-9897 |
|
|
BAY-474 |
MET |
Kinase |
Inhibitor |
Yes |
BAY-827 |
|
|
BAY-549 |
ROCK1, ROCK2 |
Kinase |
Inhibitor |
Yes |
BAY-4900 |
|
|
BAY-6096 |
ADRA2B |
GPCR |
Antagonist |
Yes |
BAY-726 |
|
|
BAY-6672 |
PTGFR |
GPCR |
Antagonist |
Yes |
BAY-403 |
|
|
BAY-678 |
ELANE |
Serine Protease |
Inhibitor |
Yes |
BAY-677 |
|
|
BAY-707 |
NUDT1 |
Nudix |
Inhibitor |
Yes |
BAY-604 |
|
|
BAY-7081 |
PDE9A |
Phoshodiesterase |
Inhibitor |
Yes |
BAY-7424 |
|
|
BAY-7598 |
MMP12 |
Protease |
Inhibitor |
Yes |
BAY-694 |
|
|
BAY-784 |
GNRHR |
GPCR |
Antagonist |
Yes |
BAY-786 |
|
|
BAY-826 |
TIE1, TEK, DDR1, DDR2 |
Kinase |
Inhibitor |
Yes |
BAY-309 |
|
|
BAY-876 |
SLC2A1 |
Solute carrier |
Inhibitor |
Yes |
BAY-588 |
|
|
BAY-885 |
MAPK7 |
MAPK (Mitogen-Activated Protein Kinases) |
Inhibitor |
No |
BAY-693 |
|
|
BAY-899 |
LHCGR |
Glycoprotein hormone GPCR |
Allosteric antagonist |
Yes |
BAY-897 |
|
|
BAY-985 |
TBK1, IKBKE |
Kinase |
Inhibitor |
Yes |
BAY-440 |
|
|
BAY1125976 |
AKT1/2 |
Kinase |
Allosteric inhibitor |
Yes |
BAY-940 |
|
|
BI 207127 |
HCV NS5B |
RNA polymerase |
Inhibitor |
Yes |
BI-7656 |
|
|
BI 605906 |
IKBKB |
Kinase |
Inhibitor |
Yes |
BI-5026 |
|
|
BI 639667 |
CCR1 |
Chemokines |
Antagonist |
Yes |
BI-9307 |
|
|
BI 653048 |
NR3C1 |
Nuclear hormone receptors |
Agonist |
Yes |
BI-3047 |
|
|
BI 665915 |
ALOX5AP |
Other |
Inhibitor |
Yes |
BI-0153 |
|
|
BI 99179 |
FASN |
Synthase |
Inhibitor |
No |
BI 99990 |
|
|
BI-1230 |
HCV NS3 |
Serine Protease |
Inhibitor |
Yes |
BI-1675 |
|
|
BI-1935 |
EPHX2 |
Hydrolase |
Inhibitor |
Yes |
BI-2049 |
|
|
BI-1942 |
CMA1 |
Serine protease |
Inhibitor |
No |
|
|
|
BI-1950 |
ITGAL |
Integrin family |
Inhibitor |
Yes |
BI-9446 |
|
|
BI-2081 |
FFAR1 |
GPCR |
Agonist |
Yes |
BI-0340 |
|
|
BI-2540 |
HIV NNRT |
Reverse transcriptase |
Inhibitor |
Yes |
BI-2439 |
|
|
BI-2545 |
ENPP2 |
Phosphodiesterase 2 |
Inhibitor |
Yes |
BI-3017 |
|
|
BI-3231 |
HSD17B13 |
17β-hydroxysteroid dehydrogenases |
Inhibitor |
Yes |
BI-0955 |
|
|
BI-3802 |
BCL6 |
transcription factor |
Degrader |
No |
BI-5273 |
|
|
BI-3812 |
BCL6 |
transcription factor |
Inhibitor |
No |
BI-5273 |
|
|
BI-4394 |
MMP13 |
Matrix metalloproteinases |
Inhibitor |
Yes |
BI-4395 |
|
|
BI-5524 |
ELANE |
Chymotrypsin |
Inhibitor |
Yes |
BI-5525 |
|
|
BI-8668 |
Epithelial sodium channel (ENaC) |
Sodium channels |
Inhibitor |
Yes |
BI-0337 |
|
|
BI-9627 |
SLC9A1 |
Solute carrier |
Antagonist |
Yes |
BI-0054 |
|
|
BIBO3304 |
NPY1R |
GPCR |
Antagonist |
Yes |
BIBO3457 |
|
|
Borussertib |
AKT1, AKT2 |
Kinase |
Covalent-allosteric inhibitor |
Yes |
RL2578 |
|
|
BTZO-1 |
MIF |
MIF |
Activator |
No |
BTZO-4 |
|
|
CCT369260 |
BCL6 |
Transcription factor |
Degrader |
Yes |
CCT393732 |
|
|
CRTH2 antagonist |
PTGDR2 |
GPCR |
Antagonist |
Yes |
CRTH2 negative control |
|
|
ERKi |
MAPK3, MAPK1 |
Kinase |
Inhibitor |
Yes |
ERKi-NC |
|
|
FHT-2344 |
SMARCA2, SMARCA4 |
SWI/SNF |
Inhibitor |
Yes |
FHT-5908 |
|
|
FS-694 |
MAPK14 |
Kinase |
Inhibitor (Type 1.5 binding mode) |
No |
FM-743 |
|
|
GNE-2256 |
IRAK4 |
Kinase |
Inhibitor |
Yes |
GNE-6689 |
|
|
GSK046 |
BRD2, BRD3, BRD4, BRDT |
BET (BD2) |
Inhibitor |
Yes |
|
|
|
GSK620 |
BRD2, BRD3, BRD4, BRDT |
BET (BD2) |
Inhibitor |
Yes |
|
|
|
GSK778 |
BRD2, BRD3, BRD4, BRDT |
BET (BD1) |
Inhibitor |
Yes |
|
|
|
GSK789 |
BRD2, BRD3, BRD4, BRDT |
BET (BD1) |
Inhibitor |
No |
GSK791 |
|
|
GSK973 |
BRD2, BRD3, BRD4, BRDT |
BET (BD2) |
Inhibitor |
Yes |
GSK943 |
|
|
GSM1 |
Gamma secretase complex |
Protease |
Modulator |
Yes |
GSM-NC |
|
|
IPP/CNRS-A017 |
DHODH |
Dihydroorotate dehydrogenase |
Inhibitor |
No |
IPP/CNRS-A019 |
|
|
JNJ-39758979 |
HRH4 |
GPCR |
Orthosteric antagonist |
Yes |
JNJ-39668551 |
|
|
JNJ-42226314 |
MGLL |
Serine hydrolase |
competitive, Non-covalent, Reversible inhibitor |
Yes |
JNJ-8034 |
|
|
JNJ-42396302 |
PDE10A |
Phosphodiesterase |
Inhibitor |
Yes |
JNJ-40573663 |
|
|
JNJ-4355 |
MCL1 |
BCL2 protein family |
Inhibitor |
Yes |
JNJ-78732576 |
|
|
JNJ-54119936 |
RORC |
Nuclear hormone receptor |
Inverse agonist |
Yes |
JNJ-53721590 |
|
|
JNJ-6204 |
CSNK1D/CSNK1E |
Kinase |
Inhibitor |
Yes |
JNJ-0293 |
|
|
JNJ-65355394 |
OGA |
Hydrolase |
Inhibitor |
Yes |
JNJ-73924149 |
|
|
JNJ-9350 |
SMOX |
Oxidase |
Inhibitor |
Yes |
JNJ-4545 |
|
|
JP3000 |
RXRA, RXRB, RXRG |
Nuclear receptors |
Agonist |
No |
JP3001 |
|
|
KISS1-305 |
KISS1R |
GPCR |
Agonist |
Yes |
KISS1-543 |
|
|
MLi-2 |
LRRK2 |
Kinase |
Inhibitor |
Yes |
MLi-2-NC |
|
|
MRK-560 |
Gamma secretase complex |
Protease |
Inhibitor |
Yes |
GSI-NC |
|
|
MRL-650 |
CNR1 |
GPCR |
Inverse agonist |
Yes |
MRL-CB1-NC |
|
|
MRL-SYKi |
SYK |
Kinase |
Inhibitor |
Yes |
MRL-SYKi-NC |
|
|
MSC-4381 |
SLC16A3 |
Monocarboxylate transporter |
Inhibitor |
Yes |
MSC-0516 |
|
|
MSD-CYP11B2 |
CYP11B2 |
Cytochrome P450 Family 11 |
Inhibitor |
Yes |
MSD-CYP11B2 Negative control |
|
|
MSD-M1PAM |
CHRM1 |
GPCR |
Positive allosteric modulator |
Yes |
MSD-M1PAM-NC |
|
|
NVS-MALT1 |
MALT1 |
Protease (Paracaspase) |
Allosteric inhibitor |
Yes |
NVS-MALT1-C |
|
|
Ogerin |
GPR68 |
GPCR |
Positive allosteric modulator |
Yes |
ZINC32547799 |
|
|
PF-04418948 |
PTGER2 |
GPCR |
Antagonist |
Yes |
PF-04475866 |
|
|
PF-04457845 |
FAAH |
Hydrolase |
Inhibitor |
Yes |
PF-04875474 |
|
|
PF-05105679 |
TRPM8 |
Ion channel |
Antagonist |
Yes |
PF-05257137 |
|
|
PFI-653 |
VNN1 |
Hydrolase |
Inhibitor |
Yes |
PFI-653-N |
|
|
PPTN |
P2RY14 |
GPCR |
Antagonist |
Yes |
PPTN-NC |
|
|
SAFit2 |
FKBP5 |
Isomerase |
Inhibitor |
Yes |
ddSAFit2 |
|
|
SGK3-PROTAC1 |
SGK3 |
|
Degrader |
No |
cisSGK3-PROTAC1 |
|
|
Skepinone-L |
MAPK14 |
Kinase |
Inhibitor (Type 1 binding mode) |
Yes |
FM-743 |
|
|
SR-302 |
DDR1, DDR2, MAPK11, MAPK14 |
Kinase |
Inhibitor |
No |
SR-301 |
|
|
SR-318 |
MAPK14 |
Kinase |
Inhibitor (Type 2 binding mode) |
No |
SR-321 |
|
|
T-26c |
MMP13 |
Peptidase |
Inhibitor |
Yes |
T-26f |
|
|
T3-CLK |
CLK1, CLK2, CLK3, CLK4 |
Kinase |
Inhibitor |
No |
T3-CLK-N |
|
|
THPP-1 |
PDE10A |
Phosphodiesterase |
Inhibitor |
Yes |
THPP-1-NC |
|
|
TP-004 |
METAP2 |
Peptidase |
Inhibitor |
Yes |
TPn-004 |
|
|
TP-008 |
ACVR1B, TGFBR1 |
Kinase |
Inhibitor |
No |
Al11 |
|
|
TP-020 |
MGAT2 |
Transferase |
Inhibitor |
Yes |
TP-020n |
|
|
TP-021 |
BCL6 |
Transcription factor |
Inhibitor |
Yes |
TP-021n |
|
|
TP-024 |
GPR52 |
GPCR |
Agonist |
Yes |
TP-024n |
|
|
TP-030-1 |
RIPK1 |
Kinase |
Inhibitor |
Yes |
TP-030n |
|
|
TP-030-2 |
RIPK1 |
Kinase |
Inhibitor |
Yes |
TP-030n |
|
|
TP-040 |
OGA |
Hydrolase |
Inhibitor |
Yes |
TP-040n |
|
|
TP-050 |
GRIN2A |
|
Positive allosteric modulator |
Yes |
TP-050n |
|
|
TP-051 |
FFAR1 |
GPCR |
Agonist |
Yes |
TP-051n |
|
|
TP-060 |
UGCG |
Glucosyltransferase |
Allosteric inhibitor |
Yes |
TP-060n |
|
|
UCSF924 |
DRD4 |
GPCR |
Agonist |
Yes |
UCSF924NC |
|
|
VZ185 |
BRD7, BRD9 |
Bromodomain-containing protein family |
Degrader |
No |
cisVZ185 |
|
|
WEB2086 |
PTAFR |
GPCR |
Inhibitor |
Yes |
WEB2387 |
|
|
WM-1119 |
KAT6A, KAT6B |
Histone acetyltransferase |
Inhibitor |
Yes |
WM-2474 |
|
|