Donated chemical probes

In this unique project, pharmaceutical companies and leading academic laboratories make their innovative high-quality chemical probes available to the research community through the SGC. These donated probes complement the probes generated by the SGC and its collaborators. All compounds accepted into the donated probes program meet the chemical probe quality criteria and have been evaluated by an internal as well as an external expert committee. Moreover, several probes are suitable for in vivo use. Control compounds are also provided and profiled. 

Brochure_Donated Chemical Probes (May 2024)

We are inviting other companies and academics to contact us and provide additional high-quality probes to the community. Please contact us at frankfurt@thesgc.org. Find more information about the donated chemical probes program.

The table below contains the entire collection of donated chemical probes. To browse the collection, find associated data, or acquire samples, select the desired chemical probe in the table below and follow the links that appear on that page. You can sort the table by clicking the column headers.

Probe Name Probe Structure Protein Family Target protein Control name Control structure Cellular usage
BI-1915 Protease CTSS BI-1920 1 µM
BI-113823 GPCR BDKRB1 BI-5832 100 nM
JNJ-54082730 Hydrolase PDE2A JNJ-54103985 1 µM
JNJ-3738 Kinase CDK7 JNJ-6240 1 µM
BAY-9835 Protease ADAMTS7, ADAMTS12 BAY-1880 100 nM
ABT-724 GPCR DRD4 A-769
ERKi Kinase MAPK3, MAPK1 ERKi-NC
BAY-7598 Protease MMP12 BAY-694
BI 99179 Synthase FASN BI 99990
BAY-474 Kinase MET BAY-827
(R)-9s GPCR ADRA1D (S)-9s
ABT-100 Transferase FNTB A-108
BTZO-1 Cytokine MIF BTZO-4
BAY-386 GPCR F2R BAY-448
BAY-707 Hydrolase NUDT1 BAY-604
A-485 Transferase EP300, CREBBP A-486
BI-9627 Solute carriers SLC9A1 BI-0054
TP-004 Protease METAP2 TPn-004
PF-05105679 Ion channel TRPM8 PF-05257137
PF-04418948 GPCR PTGER2 PF-04475866
BI-1935 Hydrolase EPHX2 BI-2049
GSM1 Protease Gamma secretase complex GSM-NC
MRK-560 Protease Gamma secretase complex GSI-NC
MRL-SYKi Kinase SYK MRL-SYKi-NC
MRL-650 GPCR CNR1 MRL-CB1-NC
CRTH2 antagonist GPCR PTGDR2 CRTH2 negative control
TP-021 Transcription factor BCL6 TP-021n
TP-020 Transferase MGAT2 TP-020n
BAY-784 GPCR GNRHR BAY-786
BAY-1797 Ion channel P2X4 BAY-207
BI-1950 Integrin ITGAL BI-9446
BI 653048 Nuclear hormone receptor NR3C1 BI-3047
BI 639667 GPCR CCR1 BI-9307
BI-2545 Phosphodiesterase ENPP2 BI-3017
BAY-885 Kinase MAPK7 BAY-693
BI-4394 Protease MMP13 BI-4395
A-079 Ion channel TRPA1 A-226
BAY-678 Protease ELANE BAY-677
BAY-876 Solute carriers SLC2A1 BAY-588
T-26c Protease MMP13 T-26f
ABT-546 GPCR EDNRA A-545
PF-04457845 Hydrolase FAAH PF-04875474
KISS1-305 GPCR KISS1R KISS1-543
A-1155463 Regulator protein BCL2L1 A-1107969
A-1211212 Regulator protein BCL2 A-1210227
IPP/CNRS-A017 Dehydrogenase DHODH IPP/CNRS-A019
MSD-M1PAM GPCR CHRM1 MSD-M1PAM-NC
A-1596586 Ion channel CFTR A-1596584
MSD-CYP11B2 Cytochrome P450 CYP11B2 MSD-CYP11B2 Negative control
THPP-1 Phosphodiesterase PDE10A THPP-1-NC
PPTN GPCR P2RY14 PPTN-NC
BAY-549 Kinase ROCK1, ROCK2 BAY-4900
TP-008 Kinase ACVR1B, TGFBR1 Al11
MLi-2 Kinase LRRK2 MLi-2-NC
UCSF924 GPCR DRD4 UCSF924NC
T3-CLK Kinase CLK1, CLK2, CLK3, CLK4 T3-CLK-N
BAY-293 Nucleotide exchange factor SOS1 BAY-294
A-192621 GPCR EDNRB A-1806262
BI-1230 Protease HCV NS3 BI-1675
TP-024 GPCR GPR52 TP-024n
BI-2540 Reverse transcriptase HIV NNRT BI-2439
BAY-390 Ion channel TRPA1 BAY-9897
BAY-069 Amino acid transaminase BCAT1, BCAT2 BAY-771
TP-030-2 Kinase RIPK1 TP-030n
TP-030-1 Kinase RIPK1 TP-030n
(R)-ZINC-3573 GPCR MRGPRX2 (S)-ZINC-3573
Ogerin GPCR GPR68 ZINC32547799
WM-1119 Transferase KAT6A, KAT6B WM-2474
SR-302 Kinase DDR1, DDR2, MAPK11, MAPK14 SR-301
NVS-MALT1 Protease MALT1 NVS-MALT1-C
BAY-3827 Kinase PRKAA1, RPS6KA1 BAY-974
FS-694 Kinase MAPK14 FM-743
Skepinone-L Kinase MAPK14 FM-743
SR-318 Kinase MAPK14 SR-321
BAY-179 Protease Complex I BAY-070 Yes
BAY-899 GPCR LHCGR BAY-897
BAY-985 Kinase TBK1, IKBKE BAY-440
Borussertib Kinase AKT1, AKT2 RL2578
BAY-091 Kinase PIP4K2A BAY-0361
MSC-4381 Monocarboxylate transporter SLC16A3 MSC-0516
PFI-653 Hydrolase VNN1 PFI-653-N
JNJ-54119936 Nuclear hormone receptor RORC JNJ-53721590
JNJ-42396302 Phosphodiesterase PDE10A JNJ-40573663
TP-040 Hydrolase OGA TP-040n
8RK64 Regulator protein UCHL1 JYQ88
A-446 Hydrolase GLS A-426
BI-1942 Protease CMA1
BI 605906 Kinase IKBKB BI-5026
GSK973 Bromodomains BRD2, BRD3, BRD4, BRDT GSK943
GSK620 Bromodomains BRD2, BRD3, BRD4, BRDT
GSK046 Bromodomains BRD2, BRD3, BRD4, BRDT
GSK789 Bromodomains BRD2, BRD3, BRD4, BRDT GSK791
GSK778 Bromodomains BRD2, BRD3, BRD4, BRDT
BAY-3153 GPCR CCR1 BAY-173
BAY-6672 GPCR PTGFR BAY-403
BI 207127 RNA polymerase HCV NS5B BI-7656
BAY 1816032 Kinase BUB1 BAY-283
JNJ-9350 Oxidase SMOX JNJ-4545
SAFit2 Isomerase FKBP5 ddSAFit2
CCT369260 Transcription factor BCL6 CCT393732
JNJ-39758979 GPCR HRH4 JNJ-39668551
JNJ-6204 Kinase CSNK1D/CSNK1E JNJ-0293
BI-2081 GPCR FFAR1 BI-0340
TP-051 GPCR FFAR1 TP-051n
TP-050 Ion channel GRIN2A TP-050n
GNE-2256 Kinase IRAK4 GNE-6689
BAY1125976 Kinase AKT1/2 BAY-940
JNJ-65355394 Hydrolase OGA JNJ-73924149
BAY 1816032 2OG BUB1 BAY-283
BI-5524 Chymotrypsin ELANE BI-5525
WEB2086 GPCR PTAFR WEB2387
BIBO3304 GPCR NPY1R BIBO3457
SGK3-PROTAC1 Kinase SGK3 cisSGK3-PROTAC1
VZ185 Bromodomain-containing protein family BRD7, BRD9 cisVZ185
BAY-277 Aminopeptidase METAP2 BAY-8805
BAY-6096 GPCR ADRA2B BAY-726
BAY 1753011 GPCR AVPR1A, AVPR2 BAY-2297
BI-8668 Sodium channels Epithelial sodium channel (ENaC) BI-0337
BI-3812 Transcription factor BCL6 BI-5273
BI-3802 Transcription factor BCL6 BI-5273
JP3000 Nuclear hormone receptor RXRA, RXRB, RXRG JP3001
TP-060 Glucosyltransferase UGCG TP-060n
JNJ-42226314 Serine hydrolase MGLL JNJ-8034
JNJ-4355 BCL2 protein family MCL1 JNJ-78732576
BAY-7081 Phoshodiesterase PDE9A BAY-7424
FHT-2344 SWI/SNF SMARCA2, SMARCA4 FHT-5908
BI-3231 17β-hydroxysteroid dehydrogenases HSD17B13 BI-0955
BAY-826 Kinase TIE1, TEK, DDR1, DDR2 BAY-309
BI-665915 Lipoxygenase ALOX5AP BI-0153