Potent, selective and cell-permeable inhibitors of protein function ("chemical probes") are valued reagents in both fundamental and applied biological research, and they are essential for the early stages of drug discovery by allowing preclinical target validation in both academic and industrial laboratories.
SGC chemical probes meet the following criteria:
Every SGC probe is accompanied by a web resource containing relevant information
SGC chemical probes are open-access reagents that are meant to be used by the biomedical research community with no restrictions on use. To acquire a sample, follow the links on the webpage of your desired chemical probe. You can sort the table by clicking the column headers.
The SGC also shares cell-active broad spectrum inhibitors of a specific epigenetic target family. These are the pan-bromodomain inhibitor, bromosporine, and the pan-demethylase inhibitor, IOX-1.