Our Science
The SGC is a public-private partnership to promote the development of new
medicines by carrying out basic science of relevance to drug discovery.
The core mandate of the SGC is to determine 3D structures of proteins
of
biomedical importance and proteins that represent potential drug targets.
Open Access
The SGC and its scientists are committed to making their research outputs available without restriction on use: this means they will not agree to file for patent protection on any research output, and will require the same commitment from any research collaborator.
Structure of the week
Substrate binding domain of the human Heat Shock 70kDa protein 9 (mortalin)
The mitochondrial Stress-70 protein HSPA9 (mortalin/mthsp70/Grp75/PBP74) is a member of the heat shock-70 family of chaperones (Hsp70). HSPA9 plays multiple functions ranging from stress response, intracellular trafficking, antigen processing, and control of cell proliferation, differentiation, and tumorigenesis. HSPA9 consist of two major functional domains: an N-terminal nucleotide binding domain, and a C-terminal substrate binding domain. Here, the structure of part of the substrate binding domain of HSPA9 was solved and refined to 2.8 Å resolution.
Latest PRE-RELEASE COORDINATES
Human vaccinia related kinase 1PDB ID: 3OP5 - Deposition Date: Aug 31 2010
Human Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptidePDB ID: 3OP0 - Deposition Date: Aug 31 2010
Human transketolasePDB ID: 3OOY - Deposition Date: Aug 31 2010
Human activin A receptor, type I in complex with the imidazo[1,2-b]pyridazine inhibitor K00507PDB ID: 3OOM - Deposition Date: Aug 31 2010
Publication of the week
Open-access public-private partnerships to enable drug discovery--new approaches.
IDrugs. (2010) 13(3):175-80.
The productivity of the pharmaceutical industry has been in steady decline during the past 40 years, posing a significant challenge to society because of the importance of developing drugs for the treatment of unmet medical needs. In this article we analyse how open-access collaborative partnerships can help decrease the attrition of drug development programs, where sharing of early-stage research data is expected to enable scientific discovery by engaging a broader section of the scientific community in the exploration of new findings.
SGC News + Events
PLoS Biology and MCP adopt iSee to enhance articles with interactive 3D molecular graphics
PLoS Biology and Molecular and Cellular Proteomics are now accepting and publishing articles enhanced using iSee, developed by the SGC and Molsoft (San Diego). In these enhanced papers, the reader can interactively rotate, translate, zoom and examine 3D representations that are fully integrated to the main text. Read more...
