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Contribute Your Proteins to Target 2035

Contribute Your Purified Proteins to Accelerate Open Data in Drug Discovery

Contribute Your Purified Proteins to Accelerate Open Data in Drug Discovery

The SGC and its partners are leading a transformative effort to revolutionize small molecule hit discovery, but we can’t do it alone! Expanding the diversity of screened protein targets is critical, and we are inviting community domain experts around the world to contribute. 

As part of the Target 2035 initiative, we will develop large, openly accessible datasets of high-quality protein-small molecule binding data. Using Affinity Selection Mass Spectrometry (AS-MS) and DNA-encoded chemical libraries (DEL), we will screen 2,000 human proteins over the next five years. The resulting data will be shared openly, challenging the machine learning community to predict new, diverse small molecule binders. 

And this is where you come in! By contributing your purified protein for screening at SGC, you can support this initiative while gaining access to small molecule hit information in return. This is a unique opportunity to advance your own research while supporting the creation of a comprehensive, open protein-ligand interaction dataset, driving forward ML/AI-driven drug discovery.

Fill out our Protein Intake Form

What We Need From You

To advance “hit-finding” algorithms, we need purified proteins that meet our screening criteria. While the SGC has access to more than 1,000 human proteins, community contributions will help expand the diversity of targets screened in industry standard platforms. 

We invite you to share the proteins your team has produced for hit-finding. With ~60 nmol, your protein (~2 mg for a 30 kDa protein) will be screened using AS-MS. The data generated from your protein will be combined with other datasets to create a large, publicly available resource. All data will be made available through AIRCHECK, our rapidly growing, cloud-based Artificial Intelligence-Ready CHEmiCal Knowledge base, ensuring that this valuable resource is accessible to the global scientific community. The identity of any hits will be provided to you without restriction, supporting your research and aligning with our commitment to open data and ML/AI-driven drug discovery.

Characterization Data Required

To get started, please complete our intake form for proteins you are interested in screening. If you have any questions, at proteins@thesgc.com. We look forward to receiving your submissions.

Collaboration Opportunities

While the default arrangement ensures that “hits” are returned to the donating scientist and the screening data is placed into the public domain after quality checks, we offer three optional collaboration opportunities:

  1. Benchmarking Challenge Participation: Opt-in to allow your data to be used in benchmarking challenges (e.g., CASP), with a slight delay in the public release to ensure high-quality standards.
  2. Collaboration with SGC Chemistry Teams: Opt-in to collaborate directly with SGC’s chemistry teams, contributing to the development of cutting-edge small molecule discovery methods.
  3. Industry Collaboration: Opt-in to share your research with our industry partners, opening the door to potential collaborations with leading pharmaceutical companies.

Open Data Integration

Your participation contributes directly to our open data strategy, which aims to democratize drug discovery by creating high-quality, openly accessible datasets. By sharing your protein samples, you are not just advancing your research—you are contributing to a global effort to make drug discovery faster, more efficient, and more accessible through open science.