Epigenetics

Epigenetics involves the regulation of genomic functions, including gene expression. Epigenetic modifications are partly inherited, but unlike the genome itself, are cell specific, plastic, and responsive to environmental influences. There are two main mechanisms, which work in concert:

 
Acetyl
 
Methyl

Click the individual readers, writers and erasers for more information on each.

 

DNA methylation and histone modifications (acetylation, methylation, phosphorylation, etc.) and the SGC’s interest is mainly in histone modifications. A number of different domain types interact with histone tails to read, write or erase protein side chain modifications. The SGC develops chemical probes to study the roles the various domains play in genomic functions.

Released: 20 Feb 2017
Released: 27 Jan 2017
Released: 20 Jan 2017

Epigenetics project with the involvement of:

Tools to explore Epigenetics

CHROMOHUB

Explore data and information published by the scientific community on chromatin biology mapped onto phylogenetic trees.

Histone Tails

Explore structural mechanisms underlying recognition of histone tails by the readers, writers and erasers of epigenetic marks.

How our probes are developed

Key Publications

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