Epigenetics involves the regulation of genomic functions, including gene expression. Epigenetic modifications are partly inherited, but unlike the genome itself, are cell specific, plastic, and responsive to environmental influences. There are two main mechanisms, which work in concert:
Click the individual readers, writers and erasers for more information on each.
DNA methylation and histone modifications (acetylation, methylation, phosphorylation, etc.) and the SGC’s interest is mainly in histone modifications. A number of different domain types interact with histone tails to read, write or erase protein side chain modifications. The SGC develops chemical probes to study the roles the various domains play in genomic functions.
Epigenetics project with the involvement of:
Explore data and information published by the scientific community on chromatin biology mapped onto phylogenetic trees.
Explore structural mechanisms underlying recognition of histone tails by the readers, writers and erasers of epigenetic marks.
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol. 2013 Mar;9(3):184-91
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 2012 Aug 16;488(7411):404-8
Histone recognition and large-scale structural analysis of the human bromodomain family. Cell. 2012 Mar 30;149(1):214-31.
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol. 2011 Jul 10;7(8):566-74
Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73