Katharina Duerr

Group Leader

University of Oxford

Katharina studied biochemistry in Frankfurt (Germany) and graduated with honors in 2003. Following a year in cancer research at the University Childrens’ Hospital Ulm (Germany) under the mentorship of Prof Simone Fulda, she pursued her PhD studies with Prof Bamberg and Prof Friedrich at the Max-Planck-Institute of Biophysics in Frankfurt and at the Technical University of Berlin. Her PhD work focused on the ion transport of electrogenic and electroneutral P-type ATPases, investigating the functional significance of accessory b-subunits for pump activity by voltage clamp fluorometry and atomic absorption spectroscopy. After graduating summa cum laude in 2009, she joined the lab of Dr Eric Gouaux at the Vollum Institute, Oregon Health & Science University in Portland, OR (USA). In her postdoctoral research she studied ionotropic glutamate receptors using a combination of X-ray crystallography, electrophysiology and single-particle cryo-electron microscopy. In 2016, she returned to Europe to become a group leader at the SGC Oxford.

Research Areas

We determine the structures of medically relevant membrane proteins by X-ray crystallography and single particle cryo-electron microscopy, using engineered yet functional variants of human membrane proteins or of their close orthologs.

Group Members

  • Gamma Chi
  • Pengchao Guo
  • Henry Man
  • Christophe Moreau
  • Matthew Snee

Publications

Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states.
Dürr, KL; Chen, L; Stein, RA; De Zorzi, R; Folea, IM; Walz, T; Mchaourab, HS; Gouaux, E;
Cell. 2014 158:778-792. doi:
PMID: 25109876

E2P State Stabilization by the N-terminal Tail of the H,K-ATPase  -Subunit Is Critical for Efficient Proton Pumping under in Vivo Conditions
Durr, KL; Abe, K; Tavraz, NN; Friedrich, T;
Journal of Biological Chemistry. 2009 284:20147-20154. doi: 10.1074/jbc.M109.005769
PMID:

A D-pathway mutation decouples the Paracoccus denitrificans cytochrome c oxidase by altering the side-chain orientation of a distant conserved glutamate.
Dürr, KL; Koepke, J; Hellwig, P; Müller, H; Angerer, H; Peng, G; Olkhova, E; Richter, OM; Ludwig, B; Michel, H;
Journal of Molecular Biology. 2008 384:865-877. doi:
PMID: 18930738

2014

Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states.
Dürr, KL; Chen, L; Stein, RA; De Zorzi, R; Folea, IM; Walz, T; Mchaourab, HS; Gouaux, E;
Cell. 2014 158:778-792. doi:
PMID: 25109876

2013

2012

2010

2009

E2P State Stabilization by the N-terminal Tail of the H,K-ATPase  -Subunit Is Critical for Efficient Proton Pumping under in Vivo Conditions
Durr, KL; Abe, K; Tavraz, NN; Friedrich, T;
Journal of Biological Chemistry. 2009 284:20147-20154. doi: 10.1074/jbc.M109.005769
PMID:

Impaired plasma membrane targeting or protein stability by certain ATP1A2 mutations identified in sporadic or familial hemiplegic migraine
Neslihan N. Tavraz, Katharina L. Dürr, Jan B. Koenderink, Tobias Freilinger, Ernst Bamberg, Martin Dichgans and Thomas Friedrich
Channels Landes Bioscience . 2009 1, 82-87 . doi:
PMID: 19372756

Functional Significance of E2 State Stabilization by Specific  / -Subunit Interactions of Na,K- and H,K-ATPase
Durr, KL; Tavraz, NN; Dempski, RE; Bamberg, E; Friedrich, T;
Journal of Biological Chemistry. 2009 284:3842-3854. doi: 10.1074/jbc.M808101200
PMID:

2008

A D-pathway mutation decouples the Paracoccus denitrificans cytochrome c oxidase by altering the side-chain orientation of a distant conserved glutamate.
Dürr, KL; Koepke, J; Hellwig, P; Müller, H; Angerer, H; Peng, G; Olkhova, E; Richter, OM; Ludwig, B; Michel, H;
Journal of Molecular Biology. 2008 384:865-877. doi:
PMID: 18930738

Diverse Functional Consequences of Mutations in the Na+/K+-ATPase  2-Subunit Causing Familial Hemiplegic Migraine Type 2
Tavraz, NN; Friedrich, T; Durr, KL; Koenderink, JB; Bamberg, E; Freilinger, T; Dichgans, M;
Journal of Biological Chemistry. 2008 283:31097-31106. doi: 10.1074/jbc.M802771200
PMID:

2007

Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells
Vogler, M; Dürr, K; Jovanovic, M; Debatin, K-M; Fulda, S;
Oncogene. 2007 26:248-257. doi: 10.1038/sj.onc.1209776
PMID:

2005

Probing the access of protons to the K pathway in the Paracoccus denitrificans cytochrome c oxidase
Richter, O-MH; Dürr, KL; Kannt, A; Ludwig, B; Scandurra, FM; Giuffrè, A; Sarti, P; Hellwig, P;
The Federation of European Biochemical Societies (FEBS) Journal. 2005 272:404-412. doi: 10.1111/j.1742-4658.2004.04480.x
PMID:

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