Wyatt Yue is a structural biologist trained from both academic and industrial background, with experience in studying diverse biology including membrane transport, chromatin modification, and human metabolism. Having obtained a BA at University of Oxford and a PhD in crystallography at Birkbeck College University of London, he pursued postdoctoral training at the Institute of Cancer Research with Laurence Pearl FRS, followed by a stint as scientist at the fragment-based drug discovery company Sareum Ltd. In 2008 he joined the SGC first as team leader of high throughput structure determination in Udo Oppermann’s group, and later In 2011 established the ‘Metabolism & Organelle Biogenesis’ (MOB) group.
The MOB group combines structural, biochemical, and chemical biology approaches to study the functions and structure-activity relationships of diverse metabolic protein families in the human genome, with emphasis on understanding the molecular basis of inherited metabolic disorders and potentials of small molecule therapeutics. Research activities in the group include the heterologous expression, chromatography purification, biophysical characterization and crystal structure determination of human metabolic enzymes of medical interest. Our mission statement: We study the roles proteins play in human metabolism and organelle biogenesis We identify the underlying protein defects in inherited metabolic disorders We collaborate with clinicians, pharmaceutical partners and patient groups to develop small molecule therapies