Chas Bountra

Chief Scientist

University of Oxford

Professor Chas Bountra
Structural Genomics Consortium
NDM
University of Oxford
Old Road Campus Research Building
Roosevelt Drive
Oxford OX3 7DQ

Chas is Professor of Translational Medicine in the Nuffield Department of Clinical Medicine and Associate Member of the Department of Pharmacology at the University of Oxford. He is also a Visiting Professor in Neuroscience and Mental Health at Imperial College, London. Chas is an invited expert on several government and charitable research funding bodies, and an advisor for many academic, biotech and pharma drug discovery programmes.

Prior to coming back to Oxford, Chas was Vice President and Head of Biology at GlaxoSmithKline. He was involved in the identification of more than 40 clinical candidates for many gastro-intestinal, inflammatory and neuro-psychiatric diseases. More than 20 of these molecules progressed into patient studies and more than five of these delivered successful “Proof of Concept” data and hence progressed into late stage development. He was involved in the launch and development of the first treatment for Irritable Bowel Syndrome (Alosetron) and was the first to show that neurokinin NK1 antagonists are anti-emetic in preclinical and clinical studies.

His current interests are i) using X ray structures of novel human proteins to generate small molecule inhibitors, screening in human cells to identify novel targets for drug discovery, and then developing clinical candidates for evaluation in patients, pre-competitively ii) focussing on epigenetic and genetically identified proteins, because these are likely to represent better targets for drug discovery, for many cancer, inflammatory, metabolic and neuro-psychiatric diseases iii) working with colleagues in Oxford to build major programmes in rare diseases and  in Alzheimers Disease, and creating a “BioEscalator” for the rapid translation of SGC science and iv) building stronger links with local hospitals, patient groups, regulatory agencies, private investors, CROs, biotechs and large pharma companies, to create a new, more efficient ecosystem for pioneer drug discovery.

Chas believes the SGC has become a leader in human protein structural biology and epigenetics chemical biology, and is arguably one of the most successful open innovation, public – private partnerships  in the world. Furthermore, with the many recent local developments (Target Discovery Institute, Kennedy Institute), he believes Oxford is emerging as one of the major academic drug discovery centres in Europe.

He has given over 300 invited lectures.  In 2012 he was voted one of the “top innovators in the industry”.

Publications

Reconfiguring drug discovery through innovative partnerships
Grundy, R; James, L; Bountra, C; Harrison, T;
Drug Discovery World. 2014 15:70-74. doi:
PMID:

Lost but making progress--Where will new analgesic drugs come from?
Borsook, D; Hargreaves, R; Bountra, C; Porreca, F;
Science Translational Medicine. 2014 6:249sr3-. doi:
PMID: 25122640

EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial.
Rice, AS; Dworkin, RH; McCarthy, TD; Anand, P; Bountra, C; McCloud, PI; Hill, J; Cutter, G; Kitson, G; Desem, N; Raff, M; EMA401-003 study group, ;
Lancet. 2014 383:1637-1647. doi: 10.1016/S0140-6736(13)62337-5
PMID: 24507377

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain.
Picaud, S; Wells, C; Felletar, I; Brotherton, D; Martin, S; Savitsky, P; Diez-Dacal, B; Philpott, M; Bountra, C; Lingard, H; Fedorov, O; Müller, S; Brennan, PE; Knapp, S; Filippakopoulos, P;
Proceedings of the National Academy of Sciences of USA. 2013 110:19754-19759. doi:
PMID: 24248379

Mutant prolactin receptor and familial hyperprolactinemia
N, P; e, J; w, ; e, ; y, ;
New England Journal of Medicine. 2013 :-. doi:
PMID: 24195502

Angiotensin II type 2 receptor (AT2 R) localization and antagonist-mediated inhibition of capsaicin responses and neurite outgrowth in human and rat sensory neurons.
Anand, U; Facer, P; Yiangou, Y; Sinisi, M; Fox, M; McCarthy, T; Bountra, C; Korchev, YE; Anand, P;
European Journal of Pain. 2013 17:1012-1026. doi: 10.1002/j.1532-2149.2012.00269.x
PMID: 23255326

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.
Kruidenier, L; Chung, CW; Cheng, Z; Liddle, J; Che, K; Joberty, G; Bantscheff, M; Bountra, C; Bridges, A; Diallo, H; Eberhard, D; Hutchinson, S; Jones, E; Katso, R; Leveridge, M; Mander, PK; Mosley, J; Ramirez-Molina, C; Rowland, P; Schofield, CJ; Sheppard, RJ; Smith, JE; Swales, C; Tanner, R; Thomas, P; Tumber, A; Drewes, G; Oppermann, U; Patel, DJ; Lee, K; Wilson, DM;
Nature. 2012 488:404-408. doi: 10.1038/nature11262
PMID: 22842901

Animal models of epigenetic regulation in neuropsychiatric disorders.
Bountra, C; Oppermann, U; Heightman, TD;
Current Topics in Behavioral Neurosciences. 2011 7:281-322. doi: 10.1007/7854_2010_104
PMID: 21225415

Challenges and prospects for pharmacotherapy in functional gastrointestinal disorders
Sanger, GJ; Chang, L; Bountra, C; Houghton, LA;
Therapeutic Advances in Gastroenterology. 2010 3:291-305. doi: 10.1177/1756283X10369922
PMID: 21180610

Prepublication data sharing.
Toronto International Data Release Workshop Authors, ; Birney, E; Hudson, TJ; Green, ED; Gunter, C; Eddy, S; Rogers, J; Harris, JR; Ehrlich, SD; Apweiler, R; Austin, CP; Berglund, L; Bobrow, M; Bountra, C; Brookes, AJ; Cambon-Thomsen, A; Carter, NP; Chisholm, RL; Contreras, JL; Cooke, RM; Crosby, WL; Dewar, K; Durbin, R; Dyke, SO; Ecker, JR; El Emam, K; Feuk, L; Gabriel, SB; Gallacher, J; Gelbart, WM; Granell, A; Guarner, F; Hubbard, T; Jackson, SA; Jennings, JL; Joly, Y; Jones, SM; Kaye, J; Kennedy, KL; Knoppers, BM; Kyrpides, NC; Lowrance, WW; Luo, J; MacKay, JJ; Martín-Rivera, L; McCombie, WR; McPherson, JD; Miller, L; Miller, W; Moerman, D; Mooser, V; Morton, CC; Ostell, JM; Ouellette, BF; Parkhill, J; Raina, PS; Rawlings, C; Scherer, SE; Scherer, SW; Schofield, PN; Sensen, CW; Stodden, VC; Sussman, MR; Tanaka, T; Thornton, J; Tsunoda, T; Valle, D; Vuorio, EI; Walker, NM; Wallace, S; Weinstock, G; Whitman, WB; Worley, KC; Wu, C; Wu, J; Yu, J;
Nature. 2009 461:168-170. doi: 10.1038/461168a
PMID: 19741685

Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors.
Swarbrick, ME; Beswick, PJ; Gleave, RJ; Green, RH; Bingham, S; Bountra, C; Carter, MC; Chambers, LJ; Chessell, IP; Clayton, NM; Collins, SD; Corfield, JA; Hartley, CD; Kleanthous, S; Lambeth, PF; Lucas, FS; Mathews, N; Naylor, A; Page, LW; Payne, JJ; Pegg, NA; Price, HS; Skidmore, J; Stevens, AJ; Stocker, R; Stratton, SC; Stuart, AJ; Wiseman, JO;
Bioorganic and Medicinal Chemistry Letters. 2009 19:4504-4508. doi: 10.1016/j.bmcl.2009.02.085
PMID: 19520573

Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation approach.
Beswick, PJ; Blackaby, AP; Bountra, C; Brown, T; Browning, K; Campbell, IB; Corfield, J; Gleave, RJ; Guntrip, SB; Hall, RM; Hindley, S; Lambeth, PF; Lucas, F; Mathews, N; Naylor, A; Player, H; Price, HS; Sidebottom, PJ; Taylor, NL; Webb, G; Wiseman, J;
Bioorganic and Medicinal Chemistry Letters. 2009 19:4509-4514. doi: 10.1016/j.bmcl.2009.02.089
PMID: 19523822

2016

Epigenetic blockade of neoplastic transformation by bromodomain and extra-terminal (BET) domain protein inhibitor JQ-1.
Zhang, C; Su, ZY; Wang, L; Shu, L; Yang, Y; Guo, Y; Pung, D; Bountra, C; Kong, AN;
Biochemical Pharmacology. 2016 117:35-45. doi:
PMID: 27520485

Regulatory barriers to the advancement of precision medicine
Pettitt, D; Smith, J; Meadows, N; Arshad, Z; Schuh, A; DiGiusto, D; Bountra, C; Holländer, G; Barker, R; Brindley, D;
. 2016 1:319-329. doi: 10.1080/23808993.2016.1176526
PMID:

Mycolactone-mediated neurite degeneration and functional effects in cultured human and rat DRG neurons: Mechanisms underlying hypoalgesia in Buruli ulcer.
Anand, U; Sinisi, M; Fox, M; MacQuillan, A; Quick, T; Korchev, Y; Bountra, C; McCarthy, T; Anand, P;
Molecular Pain. 2016 12:-. doi:
PMID: 27325560

Open Access Could Transform Drug Discovery: A Case Study of JQ1.
Arshad, Z; Smith, J; Roberts, M; Lee, WH; Davies, B; Bure, K; Hollander, GA; Dopson, S; Bountra, C; Brindley, D;
Expert Opinion on Drug Discovery. 2016 11:321-332. doi:
PMID: 26791045

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.
Bavetsias, V; Lanigan, RM; Ruda, GF; Atrash, B; McLaughlin, MG; Tumber, A; Mok, NY; Le Bihan, YV; Dempster, S; Boxall, KJ; Jeganathan, F; Hatch, SB; Savitsky, P; Velupillai, S; Krojer, T; England, KS; Sejberg, J; Thai, C; Donovan, A; Pal, A; Scozzafava, G; Bennett, JM; Kawamura, A; Johansson, C; Szykowska, A; Gileadi, C; Burgess-Brown, NA; von Delft, F; Oppermann, U; Walters, Z; Shipley, J; Raynaud, FI; Westaway, SM; Prinjha, RK; Fedorov, O; Burke, R; Schofield, CJ; Westwood, IM; Bountra, C; Müller, S; van Montfort, RL; Brennan, PE; Blagg, J;
Journal of Medicinal Chemistry. 2016 59:1388-1409. doi:
PMID: 26741168

Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.
Chen, P; Chaikuad, A; Bamborough, P; Bantscheff, M; Bountra, C; Chung, CW; Fedorov, O; Grandi, P; Jung, D; Lesniak, R; Lindon, M; Müller, S; Philpott, M; Prinjha, R; Rogers, C; Selenski, C; Tallant, C; Werner, T; Willson, TM; Knapp, S; Drewry, DH;
Journal of Medicinal Chemistry. 2016 59:1410-1424. doi:
PMID: 25799074

2015

Decision-support tools for monoclonal antibody and cell therapy bioprocessing: Current landscape and development opportunities
Rekhi, R; Smith, JA; Arshad, Z; Roberts, M; Bountra, C; Bingham, I; Bure, K; Brindley, DA;
BioProcess International. 2015 13:-. doi:
PMID:

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy.
Picaud, S; Fedorov, O; Thanasopoulou, A; Leonards, K; Jones, K; Meier, J; Olzscha, H; Monteiro, O; Martin, S; Philpott, M; Tumber, A; Filippakopoulos, P; Yapp, C; Wells, C; Che, KH; Bannister, A; Robson, S; Kumar, U; Parr, N; Lee, K; Lugo, D; Jeffrey, P; Taylor, S; Vecellio, ML; Bountra, C; Brennan, PE; O'Mahony, A; Velichko, S; Müller, S; Hay, D; Daniels, DL; Urh, M; La Thangue, NB; Kouzarides, T; Prinjha, R; Schwaller, J; Knapp, S;
Cancer Research. 2015 75:5106-5119. doi:
PMID: 26552700

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.
Fedorov, O; Castex, J; Tallant, C; Owen, DR; Martin, S; Aldeghi, M; Monteiro, O; Filippakopoulos, P; Picaud, S; Trzupek, JD; Gerstenberger, BS; Bountra, C; Willmann, D; Wells, C; Philpott, M; Rogers, C; Biggin, PC; Brennan, PE; Bunnage, ME; Schüle, R; Günther, T; Knapp, S; Müller, S;
Science Advances. 2015 1:e1500723-. doi:
PMID: 26702435

Corrigendum: The promise and peril of chemical probes.
Arrowsmith, CH; Audia, JE; Austin, C; Baell, J; Bennett, J; Blagg, J; Bountra, C; Brennan, PE; Brown, PJ; Bunnage, ME; Buser-Doepner, C; Campbell, RM; Carter, AJ; Cohen, P; Copeland, RA; Cravatt, B; Dahlin, JL; Dhanak, D; Edwards, AM; Frederiksen, M; Frye, SV; Gray, N; Grimshaw, CE; Hepworth, D; Howe, T; Huber, KV; Jin, J; Knapp, S; Kotz, JD; Kruger, RG; Lowe, D; Mader, MM; Marsden, B; Mueller-Fahrnow, A; Müller, S; O'Hagan, RC; Overington, JP; Owen, DR; Rosenberg, SH; Ross, R; Roth, B; Schapira, M; Schreiber, SL; Shoichet, B; Sundström, M; Superti-Furga, G; Taunton, J; Toledo-Sherman, L; Walpole, C; Walters, MA; Willson, TM; Workman, P; Young, RN; Zuercher, WJ;
Nature Chemical Biology. 2015 11:887-. doi:
PMID: 26485080

Food for thought.

Nature Chemical Biology. 2015 11:1-. doi:
PMID: 25517376

Building a roadmap for developing combination therapies for Alzheimer's disease.
Perry, D; Sperling, R; Katz, R; Berry, D; Dilts, D; Hanna, D; Salloway, S; Trojanowski, JQ; Bountra, C; Krams, M; Luthman, J; Potkin, S; Gribkoff, V; Temple, R; Wang, Y; Carrillo, MC; Stephenson, D; Snyder, H; Liu, E; Ware, T; McKew, J; Fields, FO; Bain, LJ; Bens, C;
Expert Review of Neurotherapeutics: a key contribution to decision making in the treatment of neurologic and neuropsychiatric disorders. 2015 15:327-333. doi:
PMID: 25708309

Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies.
Anand, U; Yiangou, Y; Sinisi, M; Fox, M; MacQuillan, A; Quick, T; Korchev, YE; Bountra, C; McCarthy, T; Anand, P;
Molecular Pain. 2015 11:38-. doi:
PMID: 26111701

21(st) Century Cures Act: An Act of Cure or Diagnosis?
Brindley, DA; Arshad, Z; Luo, D; Dopson, S; Hollander, G; Frost, S; Bountra, C; Smith, JA;
Rejuvenation Research. 2015 18:295-298. doi:
PMID: 26291241

2014

Kruidenier et al. reply.
Kruidenier, L; Chung, CW; Cheng, Z; Liddle, J; Che, K; Joberty, G; Bantscheff, M; Bountra, C; Bridges, A; Diallo, H; Eberhard, D; Hutchinson, S; Jones, E; Katso, R; Leveridge, M; Mander, PK; Mosley, J; Ramirez-Molina, C; Rowland, P; Schofield, CJ; Sheppard, RJ; Smith, JE; Swales, C; Tanner, R; Thomas, P; Tumber, A; Drewes, G; Oppermann, U; Patel, DJ; Lee, K; Wilson, DM;
Nature. 2014 514:E2-. doi:
PMID: 25279927

Reconfiguring drug discovery through innovative partnerships
Grundy, R; James, L; Bountra, C; Harrison, T;
Drug Discovery World. 2014 15:70-74. doi:
PMID:

Lost but making progress--Where will new analgesic drugs come from?
Borsook, D; Hargreaves, R; Bountra, C; Porreca, F;
Science Translational Medicine. 2014 6:249sr3-. doi:
PMID: 25122640

EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial.
Rice, AS; Dworkin, RH; McCarthy, TD; Anand, P; Bountra, C; McCloud, PI; Hill, J; Cutter, G; Kitson, G; Desem, N; Raff, M; EMA401-003 study group, ;
Lancet. 2014 383:1637-1647. doi: 10.1016/S0140-6736(13)62337-5
PMID: 24507377

2013

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain.
Picaud, S; Wells, C; Felletar, I; Brotherton, D; Martin, S; Savitsky, P; Diez-Dacal, B; Philpott, M; Bountra, C; Lingard, H; Fedorov, O; Müller, S; Brennan, PE; Knapp, S; Filippakopoulos, P;
Proceedings of the National Academy of Sciences of USA. 2013 110:19754-19759. doi:
PMID: 24248379

Mutant prolactin receptor and familial hyperprolactinemia
N, P; e, J; w, ; e, ; y, ;
New England Journal of Medicine. 2013 :-. doi:
PMID: 24195502

Working together to identify new epigenetic targets for cancer
B, C; o, ; u, ; n, ; t, ; r, ; a, ;
Molecular Cancer Therapeutics. 2013 12:-. doi: 10.1158/1535-7163.TARG-13-PL03-01
PMID:

The structural basis of ZMPSTE24-dependent laminopathies
Quigley, A; Dong, YY; Pike, ACW; Dong, L; Shrestha, L; Berridge, G; Stansfeld, PJ; Sansom, MSP; Edwards, AM; Bountra, C; Von Delft, F; Bullock, AN; Burgess-Brown, NA; Carpenter, EP;
Science. 2013 340:1604-1607. doi: 10.1126/science.1231513
PMID:

Angiotensin II type 2 receptor (AT2 R) localization and antagonist-mediated inhibition of capsaicin responses and neurite outgrowth in human and rat sensory neurons.
Anand, U; Facer, P; Yiangou, Y; Sinisi, M; Fox, M; McCarthy, T; Bountra, C; Korchev, YE; Anand, P;
European Journal of Pain. 2013 17:1012-1026. doi: 10.1002/j.1532-2149.2012.00269.x
PMID: 23255326

2012

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.
Kruidenier, L; Chung, CW; Cheng, Z; Liddle, J; Che, K; Joberty, G; Bantscheff, M; Bountra, C; Bridges, A; Diallo, H; Eberhard, D; Hutchinson, S; Jones, E; Katso, R; Leveridge, M; Mander, PK; Mosley, J; Ramirez-Molina, C; Rowland, P; Schofield, CJ; Sheppard, RJ; Smith, JE; Swales, C; Tanner, R; Thomas, P; Tumber, A; Drewes, G; Oppermann, U; Patel, DJ; Lee, K; Wilson, DM;
Nature. 2012 488:404-408. doi: 10.1038/nature11262
PMID: 22842901

2011

Animal models of epigenetic regulation in neuropsychiatric disorders.
Bountra, C; Oppermann, U; Heightman, TD;
Current Topics in Behavioral Neurosciences. 2011 7:281-322. doi: 10.1007/7854_2010_104
PMID: 21225415

2010

Challenges and prospects for pharmacotherapy in functional gastrointestinal disorders
Sanger, GJ; Chang, L; Bountra, C; Houghton, LA;
Therapeutic Advances in Gastroenterology. 2010 3:291-305. doi: 10.1177/1756283X10369922
PMID: 21180610

2009

Prepublication data sharing.
Toronto International Data Release Workshop Authors, ; Birney, E; Hudson, TJ; Green, ED; Gunter, C; Eddy, S; Rogers, J; Harris, JR; Ehrlich, SD; Apweiler, R; Austin, CP; Berglund, L; Bobrow, M; Bountra, C; Brookes, AJ; Cambon-Thomsen, A; Carter, NP; Chisholm, RL; Contreras, JL; Cooke, RM; Crosby, WL; Dewar, K; Durbin, R; Dyke, SO; Ecker, JR; El Emam, K; Feuk, L; Gabriel, SB; Gallacher, J; Gelbart, WM; Granell, A; Guarner, F; Hubbard, T; Jackson, SA; Jennings, JL; Joly, Y; Jones, SM; Kaye, J; Kennedy, KL; Knoppers, BM; Kyrpides, NC; Lowrance, WW; Luo, J; MacKay, JJ; Martín-Rivera, L; McCombie, WR; McPherson, JD; Miller, L; Miller, W; Moerman, D; Mooser, V; Morton, CC; Ostell, JM; Ouellette, BF; Parkhill, J; Raina, PS; Rawlings, C; Scherer, SE; Scherer, SW; Schofield, PN; Sensen, CW; Stodden, VC; Sussman, MR; Tanaka, T; Thornton, J; Tsunoda, T; Valle, D; Vuorio, EI; Walker, NM; Wallace, S; Weinstock, G; Whitman, WB; Worley, KC; Wu, C; Wu, J; Yu, J;
Nature. 2009 461:168-170. doi: 10.1038/461168a
PMID: 19741685

Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors.
Swarbrick, ME; Beswick, PJ; Gleave, RJ; Green, RH; Bingham, S; Bountra, C; Carter, MC; Chambers, LJ; Chessell, IP; Clayton, NM; Collins, SD; Corfield, JA; Hartley, CD; Kleanthous, S; Lambeth, PF; Lucas, FS; Mathews, N; Naylor, A; Page, LW; Payne, JJ; Pegg, NA; Price, HS; Skidmore, J; Stevens, AJ; Stocker, R; Stratton, SC; Stuart, AJ; Wiseman, JO;
Bioorganic and Medicinal Chemistry Letters. 2009 19:4504-4508. doi: 10.1016/j.bmcl.2009.02.085
PMID: 19520573

Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation approach.
Beswick, PJ; Blackaby, AP; Bountra, C; Brown, T; Browning, K; Campbell, IB; Corfield, J; Gleave, RJ; Guntrip, SB; Hall, RM; Hindley, S; Lambeth, PF; Lucas, F; Mathews, N; Naylor, A; Player, H; Price, HS; Sidebottom, PJ; Taylor, NL; Webb, G; Wiseman, J;
Bioorganic and Medicinal Chemistry Letters. 2009 19:4509-4514. doi: 10.1016/j.bmcl.2009.02.089
PMID: 19523822

2008

Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons.
Anand, U; Otto, WR; Sanchez-Herrera, D; Facer, P; Yiangou, Y; Korchev, Y; Birch, R; Benham, C; Bountra, C; Chessell, IP; Anand, P;
Pain. 2008 138:667-680. doi: 10.1016/j.pain.2008.06.007
PMID: 18692962

Volunteer studies in pain research--opportunities and challenges to replace animal experiments: the report and recommendations of a Focus on Alternatives workshop.
Langley, CK; Aziz, Q; Bountra, C; Gordon, N; Hawkins, P; Jones, A; Langley, G; Nurmikko, T; Tracey, I;
Neuroimage. 2008 42:467-473. doi: 10.1016/j.neuroimage.2008.05.030
PMID: 18599315

Cytosine arabinoside affects the heat and capsaicin receptor TRPV1 localisation and sensitivity in human sensory neurons.
Anand, U; Otto, WR; Bountra, C; Chessell, I; Sinisi, M; Birch, R; Anand, P;
Journal of Neuro-Oncology. 2008 89:1-7. doi: 10.1007/s11060-008-9585-6
PMID: 18414789

Perspectives of Alzheimer's disease treatments.
Davis, JB; Bountra, C; Richardson, J;
Handbook of Clinical Neurology. 2008 89:273-290. doi: 10.1016/S0072-9752(07)01226-2
PMID: 18631752

2007

Voltage-gated ion channel Nav1.7 innervation in patients with idiopathic rectal hypersensitivity and paroxysmal extreme pain disorder (familial rectal pain).
Yiangou, Y; Facer, P; Chessell, IP; Bountra, C; Chan, C; Fertleman, C; Smith, V; Anand, P;
Neuroscience Letters. 2007 427:77-82. doi: 10.1016/j.neulet.2007.09.027
PMID: 17928139

Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score.
Yilmaz, Z; Renton, T; Yiangou, Y; Zakrzewska, J; Chessell, IP; Bountra, C; Anand, P;
Journal of Clinical Neuroscience. 2007 14:864-871. doi: 10.1016/j.jocn.2006.09.002
PMID: 17582772

Clinical and experimental pain processing in rheumatoid arthritis patients treated with anti-TNF
Wartolowska, K; Schweinhardt, P; Wordsworth, P; Chizh, BA; Bountra, C; Chessell, I; Tracey, I;
Rheumatology. 2007 46:I6-I7. doi:
PMID:

An NMR-based metabolic profiling study of inflammatory pain using the rat FCA model
Connor, SC; Gray, RA; Hodson, MP; Clayton, NM; Haselden, JN; Chessell, IP; Bountra, C;
Metabolomics. 2007 3:29-39. doi: 10.1007/s11306-006-0039-x
PMID:

The effect of inflammation on Fos expression in the ferret trigeminal nucleus.
Worsley, MA; Davies, SL; Clayton, NM; Bountra, C; Loescher, AR; Robinson, PP; Boissonade, FM;
European Journal of Oral Sciences. 2007 115:40-47. doi: 10.1111/j.1600-0722.2007.00411.x
PMID: 17305715

Localized and non-contact mechanical stimulation of dorsal root ganglion sensory neurons using scanning ion conductance microscopy.
Sánchez, D; Anand, U; Gorelik, J; Benham, CD; Bountra, C; Lab, M; Klenerman, D; Birch, R; Anand, P; Korchev, Y;
Journal of Neuroscience Methods. 2007 159:26-34. doi: 10.1016/j.jneumeth.2006.06.018
PMID: 16887195

Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy.
Facer, P; Casula, MA; Smith, GD; Benham, CD; Chessell, IP; Bountra, C; Sinisi, M; Birch, R; Anand, P;
BMC Neurology. 2007 7:11-. doi: 10.1186/1471-2377-7-11
PMID: 17521436

2006

Changes in sodium channel expression following trigeminal nerve injury.
Davies, SL; Loescher, AR; Clayton, NM; Bountra, C; Robinson, PP; Boissonade, FM;
Experimental Neurology. 2006 202:207-216. doi: 10.1016/j.expneurol.2006.05.035
PMID: 16908020

Pharmacological FMRI in the development of new analgesic compounds.
Schweinhardt, P; Bountra, C; Tracey, I;
NMR in Biomedicine. 2006 19:702-711. doi: 10.1002/nbm.1076
PMID: 16986120

An animal model of chronic inflammatory pain: pharmacological and temporal differentiation from acute models.
Wilson, AW; Medhurst, SJ; Dixon, CI; Bontoft, NC; Winyard, LA; Brackenborough, KT; De Alba, J; Clarke, CJ; Gunthorpe, MJ; Hicks, GA; Bountra, C; McQueen, DS; Chessell, IP;
European Journal of Pain. 2006 10:537-549. doi: 10.1016/j.ejpain.2005.08.003
PMID: 16199187

An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients.
Schweinhardt, P; Glynn, C; Brooks, J; McQuay, H; Jack, T; Chessell, I; Bountra, C; Tracey, I;
Neuroimage. 2006 32:256-265. doi: 10.1016/j.neuroimage.2006.03.024
PMID: 16679031

The effect of neurotrophic factors on morphology, TRPV1 expression and capsaicin responses of cultured human DRG sensory neurons.
Anand, U; Otto, WR; Casula, MA; Day, NC; Davis, JB; Bountra, C; Birch, R; Anand, P;
Neuroscience Letters. 2006 399:51-56. doi: 10.1016/j.neulet.2006.01.046
PMID: 16481104

COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord.
Yiangou, Y; Facer, P; Durrenberger, P; Chessell, IP; Naylor, A; Bountra, C; Banati, RR; Anand, P;
BMC Neurology. 2006 6:12-. doi: 10.1186/1471-2377-6-12
PMID: 16512913

Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations.
Mukerji, G; Yiangou, Y; Corcoran, SL; Selmer, IS; Smith, GD; Benham, CD; Bountra, C; Agarwal, SK; Anand, P;
BMC Urology. 2006 6:6-. doi: 10.1186/1471-2490-6-6
PMID: 16519806

Pain during ice water test distinguishes clinical bladder hypersensitivity from overactivity disorders.
Mukerji, G; Waters, J; Chessell, IP; Bountra, C; Agarwal, SK; Anand, P;
BMC Urology. 2006 6:31-. doi: 10.1186/1471-2490-6-31
PMID: 17192176

Nogo-A and Nogo-66 receptor in multiple sclerosis and amyotrophic lateral sclerosis spinal cord and injured human peripheral nerves
Durrenberger, P; Facer, P; Casula, MA; Prinjha, R; Moore, S; Woodhams, P; Bountra, C; Ravid, R; Birch, R; Anand, P;
Journal of Neurology, Neurosurgery and Psychiatry. 2006 77:130-130. doi:
PMID:

2005

Sodium channel Nav1.8 immunoreactivity in painful human dental pulp.
Renton, T; Yiangou, Y; Plumpton, C; Tate, S; Bountra, C; Anand, P;
BMC Oral Health. 2005 5:5-. doi: 10.1186/1472-6831-5-5
PMID: 16001984

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain.
Chessell, IP; Hatcher, JP; Bountra, C; Michel, AD; Hughes, JP; Green, P; Egerton, J; Murfin, M; Richardson, J; Peck, WL; Grahames, CB; Casula, MA; Yiangou, Y; Birch, R; Anand, P; Buell, GN;
Pain. 2005 114:386-396. doi: 10.1016/j.pain.2005.01.002
PMID: 15777864

Increased capsaicin receptor TRPV1 in skin nerve fibres and related vanilloid receptors TRPV3 and TRPV4 in keratinocytes in human breast pain.
Gopinath, P; Wan, E; Holdcroft, A; Facer, P; Davis, JB; Smith, GD; Bountra, C; Anand, P;
BMC Women's Health. 2005 5:2-. doi: 10.1186/1472-6874-5-2
PMID: 15755319

The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] is effective in animal models of neuropathic pain and central sensitization.
Bingham, S; Beswick, PJ; Bountra, C; Brown, T; Campbell, IB; Chessell, IP; Clayton, N; Collins, SD; Davey, PT; Goodland, H; Gray, N; Haslam, C; Hatcher, JP; Hunter, AJ; Lucas, F; Murkitt, G; Naylor, A; Pickup, E; Sargent, B; Summerfield, SG; Stevens, A; Stratton, SC; Wiseman, J;
Journal of Pharmacology and Experimental Therapeutics. 2005 312:1161-1169. doi: 10.1124/jpet.104.075267
PMID: 15572651

2004

nNOS expression following inferior alveolar nerve injury in the ferret.
Davies, SL; Loescher, AR; Clayton, NM; Bountra, C; Robinson, PP; Boissonade, FM;
Brain Research. 2004 1027:11-17. doi: 10.1016/j.brainres.2004.08.062
PMID: 15494152

Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors.
Beswick, P; Bingham, S; Bountra, C; Brown, T; Browning, K; Campbell, I; Chessell, I; Clayton, N; Collins, S; Corfield, J; Guntrip, S; Haslam, C; Lambeth, P; Lucas, F; Mathews, N; Murkit, G; Naylor, A; Pegg, N; Pickup, E; Player, H; Price, H; Stevens, A; Stratton, S; Wiseman, J;
Bioorganic and Medicinal Chemistry Letters. 2004 14:5445-5448. doi: 10.1016/j.bmcl.2004.07.089
PMID: 15454242

Allodynia in rats infected with varicella zoster virus--a small animal model for post-herpetic neuralgia.
Dalziel, RG; Bingham, S; Sutton, D; Grant, D; Champion, JM; Dennis, SA; Quinn, JP; Bountra, C; Mark, MA;
Brain Research Reviews. 2004 46:234-242. doi: 10.1016/j.brainresrev.2004.07.008
PMID: 15464211

Increased sodium channel Na(v)1.8 immunoreactivity in painful human dental pulp
Renton, T; Yiangou, Y; Plumpton, C; Tate, S; Bountra, C; Anand, P;
Anaesthesia. 2004 59:1040-1041. doi:
PMID:

Increase of purinergic receptor P2X(7) in injured human nerves and dorsal root ganglia
Casula, MA; Chessell, IP; Bountra, C; Yiangou, Y; Birch, R; Anand, P;
Journal of Neurology, Neurosurgery and Psychiatry. 2004 75:1227-1227. doi:
PMID:

Increased cyclooxygenase-2 (Cox-2) expression by macrophages in chronic but not acute nerve injury in humans and rodents
Durrenberger, PF; Facer, P; Gray, RA; Chessell, IP; Naylor, A; Bountra, C; Banati, RB; Elliot, D; Anand, P;
Journal of Neurology, Neurosurgery and Psychiatry. 2004 75:1228-1228. doi:
PMID:

Expression of the sodium channel beta3 subunit in injured human sensory neurons.
Casula, MA; Facer, P; Powell, AJ; Kinghorn, IJ; Plumpton, C; Tate, SN; Bountra, C; Birch, R; Anand, P;
Neuroreport. 2004 15:1629-1632. doi:
PMID: 15232296

Cyclooxygenase-2 (Cox-2) in injured human nerve and a rat model of nerve injury.
Durrenberger, PF; Facer, P; Gray, RA; Chessell, IP; Naylor, A; Bountra, C; Banati, RB; Birch, R; Anand, P;
Journal of the Peripheral Nervous System. 2004 9:15-25. doi:
PMID: 14871450

Potent, selective adenosine A1 agonists as potential analgesics
Beswick, PJ; Bountra, C; Clayton, NM; Collins, SD; Cousins, RPC; Eldred, CD; Naylor, A; Sheehan, MJ; Spalding, DJ;
Medicinal Chemistry Research. 2004 13:88-98. doi: 10.1007/s00044-004-0013-y
PMID:

2003

Sodium channel sns1 and vr1 capsaicin receptor expression in lingual nerve.
Renton, T; Yiangou, Y; Davis, J; Plumpton, C; Tate, S; Bountra, C; Anand, P;
Journal of Dental Research. 2003 82:494-494. doi:
PMID:

The role of sodium channels in injury-induced trigeminal pain.
Davies, SL; Loescher, AR; Clayton, N; Bountra, C; Robinson, PP; Boissonade, FM;
Journal of Dental Research. 2003 82:495-495. doi:
PMID:

Neuronal nitric oxide synthase (nnos) expression following inferior alveolar nerve injury.
Davies, SL; Loescher, AR; Clayton, N; Bountra, C; Robinson, PP; Boissonade, FM;
Journal of Dental Research. 2003 82:538-538. doi:
PMID:

Sodium channel blacker 4030W92 reduces spontaneous discharge from damaged axons in the lingual nerve of ferrets.
Yates, JM; Loescher, AR; Boissonade, FM; Clayton, N; Bountra, C; Robinson, PP;
Journal of Dental Research. 2003 82:B160-B160. doi:
PMID:

The effect of the sodium channel blocker 4030W92 on fos expression the jaw-opening reflex following stimulation of normal and inflamed ferret tooth pulps.
Davies, SL; Worsley, MA; Loescher, AR; Clayton, N; Bountra, C; Robinson, PP; Boissonade, FM;
Journal of Dental Research. 2003 82:B160-B160. doi:
PMID:

The effects of inflammation and the neurokinin-1 receptor antagonist GR205171A on fos expression in the ferret trigeminal nucleus following tooth pulp stimulation.
Worsley, MA; Davies, SL; Clayton, N; Bountra, C; Boissonade, FM;
Journal of Dental Research. 2003 82:B161-B161. doi:
PMID:

Increased iNOS expression in irritable bowel syndrome (IBS) patients with stress related symptoms
O'Sullivan, M; Clayton, N; Moloney, G; Bountra, C; Crotty, P; Buckley, M; O'Connor, H; O'Morain, C;
Gastroenterology. 2003 124:A389-A389. doi: 10.1016/S0016-5085(03)81969-8
PMID:

Anti-hyperalgesic and anti-inflammatory activity of a potent and selective adenosine A1 receptor agonist 5 '-deoxy-5 '-fluoro-N-(tetrahydro-pyran-4-yl)-adenosine
Clayton, NM; Collins, SD; Pass, M; Chessell, IP; Bountra, C;
British Journal of Pharmacology. 2003 138:U14-U14. doi:
PMID:

The effect of transdermal application of a highly selective adenosine A1 receptor agonist in the carrageenan model of acute inflammatory hyperalgesia
Collins, SD; Clayton, NM; Sheehan, MJ; Spalding, D; Bountra, C;
British Journal of Pharmacology. 2003 138:U15-U15. doi:
PMID:

Decreased potassium channel IK1 and its regulator neurotrophin-3 (NT-3) in inflamed human bowel.
Arnold, SJ; Facer, P; Yiangou, Y; Chen, MX; Plumpton, C; Tate, SN; Bountra, C; Chan, CL; Williams, NS; Anand, P;
Neuroreport. 2003 14:191-195. doi: 10.1097/01.wnr.0000053759.76853.85
PMID: 12598727

Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency.
Chan, CL; Facer, P; Davis, JB; Smith, GD; Egerton, J; Bountra, C; Williams, NS; Anand, P;
Lancet. 2003 361:385-391. doi:
PMID: 12573376

2002

CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain.
Clayton, N; Marshall, FH; Bountra, C; O'Shaughnessy, CT;
Pain. 2002 96:253-260. doi:
PMID: 11972997

Calcium-activated potassium channel SK1- and IK1-like immunoreactivity in injured human sensory neurones and its regulation by neurotrophic factors.
Boettger, MK; Till, S; Chen, MX; Anand, U; Otto, WR; Plumpton, C; Trezise, DJ; Tate, SN; Bountra, C; Coward, K; Birch, R; Anand, P;
Brain: a journal of neurology. 2002 125:252-263. doi:
PMID: 11844726

Nerve fibers in lumbar spine structures and injured spinal roots express the sensory neuron-specific sodium channels SNS/PN3 and NaN/SNS2.
Bucknill, AT; Coward, K; Plumpton, C; Tate, S; Bountra, C; Birch, R; Sandison, A; Hughes, SP; Anand, P;
Spine. 2002 27:135-140. doi:
PMID: 11805657

2001

The effects of a selective Cox-2 inhibitor GR253035X in rat models of inflammatory hyperalgesia assessed using behavioural readouts and by quantitation of spinal immunochemistry
Brown, T; Clayton, N; Brazdil, R; Wiseman, J; Naylor, A; Bountra, C;
British Journal of Pharmacology. 2001 134:-. doi:
PMID:

Inhibition of colorectal distension induced c-Fos expression in the spinal cord following MK801 and GV 196771 in the anaesthetised rat.
Brazdil, R; Kozlowski, CM; Clayton, NM; Stratton, SC; Bountra, C;
British Journal of Pharmacology. 2001 134:-. doi:
PMID:

The anti-hyperalgesic effects of the high and low intrinsic efficacy Adenosine(1) receptor agonists GR79236X and GR190178X in a mouse model of inflammatory hyperalgesia
Brown, T; Clayton, N; Stratton, S; Bountra, C; Sheehan, M;
British Journal of Pharmacology. 2001 134:-. doi:
PMID:

The effect of GR190178, a selective low-efficacy adenosine A1 receptor agonist, on the treatment of neuropathic hyperalgesia in the rat.
Collins, SD; Clayton, NM; Sheehan, MJ; Bountra, C;
British Journal of Pharmacology. 2001 133:-. doi:
PMID:

The effect of the selective low-efficacy adenosine A1 agonist GR190178, in models of nociceptive, acute and established pain hypersensitivity in the rat
Clayton, NM; Brown, TA; Sargent, RS; Brazdil, R; Collins, SD; Sheehan, MJ; Bountra, C;
British Journal of Pharmacology. 2001 133:-. doi:
PMID:

Colorectal distension-evoked iNOS, nitrotyrosine and C-FOS expression in the anaesthetised rat is inhibited by the selective iNOS inhibitor GW274150
Clayton, N; Kozlowski, CM; Brazdil, R; Bountra, C;
British Journal of Pharmacology. 2001 133:U79-U79. doi:
PMID:

Activation of nuclear factor-kappa B (NF-kappa B)in diarrhoea predominant irritable bowel syndrome
O'Sullivan, MA; Clayton, N; Hurle, M; Bountra, C; Buckley, M; O'Morain, CA;
Gastroenterology. 2001 120:A641-A642. doi:
PMID:

Sodium channel and nNOS expression following inferior alveolar nerve
Davies, SL; Loescher, AR; Clayton, N; Bountra, C; Robinson, PP; Boissonade, FM;
Journal of Dental Research. 2001 80:1167-1167. doi:
PMID:

Sodium channel beta1 and beta2 subunits parallel SNS/PN3 alpha-subunit changes in injured human sensory neurons.
Coward, K; Jowett, A; Plumpton, C; Powell, A; Birch, R; Tate, S; Bountra, C; Anand, P;
Neuroreport. 2001 12:483-488. doi:
PMID: 11234750

Plasticity of TTX-sensitive sodium channels PN1 and brain III in injured human nerves.
Coward, K; Aitken, A; Powell, A; Plumpton, C; Birch, R; Tate, S; Bountra, C; Anand, P;
Neuroreport. 2001 12:495-500. doi:
PMID: 11234752

Immunolocalisation of sodium channel NaG in the intact and injured human peripheral nervous system.
Coward, K; Mosahebi, A; Plumpton, C; Facer, P; Birch, R; Tate, S; Bountra, C; Terenghi, G; Anand, P;
Journal of Anatomy. 2001 198:175-180. doi:
PMID: 11273042

Increased sodium channel SNS/PN3 immunoreactivity in a causalgic finger.
Shembalkar, PK; Till, S; Boettger, MK; Terenghi, G; Tate, S; Bountra, C; Anand, P;
European Journal of Pain. 2001 5:319-323. doi: 10.1053/eujp.2001.0251
PMID: 11558987

2000

Increased mast cells in the irritable bowel syndrome.
O'Sullivan, M; Clayton, N; Breslin, NP; Harman, I; Bountra, C; McLaren, A; O'Morain, CA;
Neurogastroenterology and Motility. 2000 12:449-457. doi:
PMID: 11012945

Hoe 140 and pseudo-irreversible antagonism in the rat vas deferens in vitro.
Asghar, AU; Wheeldon, A; Coleman, RA; Bountra, C; McQueen, DS;
European Journal of Pharmacology. 2000 398:131-138. doi:
PMID: 10856457

The effect of fentanyl, DNQX and MK-801 on dorsal horn neurones responsive to colorectal distension in the anaesthetized rat.
Kozlowski, CM; Bountra, C; Grundy, D;
Neurogastroenterology and Motility. 2000 12:239-247. doi:
PMID: 10867621

Increased iNOS and nitrotyrosine expression in irritable bowel syndrome (IBS).
O'Sullivan, MA; Clayton, N; Wong, T; Bountra, C; Buckley, MM; O'Morain, CA;
Gastroenterology. 2000 118:A702-A702. doi:
PMID:

Immunolocalization of SNS/PN3 and NaN/SNS2 sodium channels in human pain states.
Coward, K; Plumpton, C; Facer, P; Birch, R; Carlstedt, T; Tate, S; Bountra, C; Anand, P;
Pain. 2000 85:41-50. doi:
PMID: 10692601

The effect of the highly selective adenosine A1 agonist GR79236 in models of nociceptive, acute and chronic inflammatory pain
Clayton, NM; Brown, T; Brazdil, R; Collins, SD; Pass, M; Sheehan, M; Bountra, C;
British Journal of Pharmacology. 2000 129:U45-U45. doi:
PMID:

The effect of GR79236, a highly selective adenosine A1 receptor agonist, on the treatment of neuropathic pain in the rat
Collins, SD; Clayton, NM; Sheehan, MJ; Pass, M; Bountra, C;
British Journal of Pharmacology. 2000 129:-. doi:
PMID:

The effect of the potent and selective iNOS (NOS-2) inhibitor GW274150 in models of acute and establised inflammatory and neuropathic pain in the rat
Clayton, NM; Alderton, W; Angel, A; Craig, C; Dawson, J; Brown, T; Collins, SD; Russell, L; Knowles, RG; Bountra, C;
European Journal of Neuroscience. 2000 12:123-123. doi:
PMID:

The effect of GR79236, a highly selective adenosine al receptor agonist, in models of nociceptive, acute and chronic inflammatory and neuropathic pain.
Collins, SD; Clayton, NM; Brown, T; Brazdil, R; Sheehan, MJ; Pass, M; Bountra, C;
European Journal of Neuroscience. 2000 12:125-125. doi:
PMID:

Neuronal apoptosis in rat dorsal root ganglia may contribute to the development of chronic hypersensitivity after chronic constriction injury
Duffy, C; Collins, SD; Nobbs, M; Bountra, C;
European Journal of Neuroscience. 2000 12:230-230. doi:
PMID:

The effect of lamotrigine and morphine on neuropathic pain in the rat
Collins, SD; Clayton, NM; Nobbs, M; Bountra, C;
. 2000 16:281-285. doi:
PMID:

1999

The pharmacological properties of the novel selective 5-HT3 receptor antagonist, alosetron, and its effects on normal and perturbed small intestinal transit in the fasted rat.
Clayton, NM; Sargent, R; Butler, A; Gale, J; Maxwell, MP; Hunt, AA; Barrett, VJ; Cambridge, D; Bountra, C; Humphrey, PP;
Neurogastroenterology and Motility. 1999 11:207-217. doi:
PMID: 10354345

Review article: the therapeutic potential of 5-HT3 receptor antagonists in the treatment of irritable bowel syndrome.
Humphrey, PP; Bountra, C; Clayton, N; Kozlowski, K;
Alimentary Pharmacology and Therapeutics. 1999 13 Suppl 2:31-38. doi:
PMID: 10429738

Increased mucosal mast cells - Evidence of an inflammatory response in IBS?
O'Sullivan, M; Breslin, NP; Harman, I; Clayton, N; Bountra, C; McLaren, A; O'Morain, CA;
Gut. 1999 44:A132-A132. doi:
PMID:

Effect of pre-emptive NMDA antagonist treatment on long-term Fos expression and hyperalgesia in a model of chronic neuropathic pain.
Munglani, R; Hudspith, MJ; Fleming, B; Harrisson, S; Smith, G; Bountra, C; Elliot, PJ; Birch, PJ; Hunt, SP;
Brain Research. 1999 822:210-219. doi:
PMID: 10082898

Effect of post-injury NMDA antagonist treatment on long-term Fos expression and hyperalgesia in a model of chronic neuropathic pain.
Hudspith, MJ; Harrisson, S; Smith, G; Bountra, C; Elliot, PJ; Birch, PJ; Hunt, SP; Munglani, R;
Brain Research. 1999 822:220-227. doi:
PMID: 10082899

Changes in spinal cord neuropeptides in the adjuvant model of chronic inflammatory hyperalgesia in the presence and absence of the NK1 receptor antagonist GR205171
Cougnon-Aptel, N; Munglani, R; Clayton, NM; Ward, P; Bountra, C;
British Journal of Pharmacology. 1999 126:U148-U148. doi:
PMID:

1998

Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons.
Tate, S; Benn, S; Hick, C; Trezise, D; John, V; Mannion, RJ; Costigan, M; Plumpton, C; Grose, D; Gladwell, Z; Kendall, G; Dale, K; Bountra, C; Woolf, CJ;
Nature Neuroscience. 1998 1:653-655. doi: 10.1038/3652
PMID: 10196578

Increased mucosal mast cells in irritable bowel syndrome (IBS).
O'Sullivan, M; Breslin, NP; Harman, I; Clayton, N; Bountra, C; McLaren, A; O'Morain, CA;
Gastroenterology. 1998 114:A816-A816. doi:
PMID:

The effect of 4030W92, a novel sodium channel blocker, on the treatment of neuropathic pain in the rat
Collins, SD; Clayton, NM; Nobbs, M; Bountra, C;
British Journal of Pharmacology. 1998 123:-. doi:
PMID:

The effect of the novel sodium channel blocker 4030W92 in models of acute and chronic inflammatory pain in the rat
Clayton, NM; Collins, SD; Sargent, R; Brown, T; Nobbs, M; Bountra, C; Trezise, DJ;
British Journal of Pharmacology. 1998 123:-. doi:
PMID:

The novel sodium channel blocker 4030W92 inhibits carrageenan-induced cutaneous hypersensitivity in the anaesthetised rat
Evans, KS; Kozlowski, CM; Bountra, C;
British Journal of Pharmacology. 1998 123:U126-U126. doi:
PMID:

The sodium channel blocker 4030W92 inhibits spinal c-Fos expression in response to somatic and visceral noxious stimulation in the rat
Kozlowski, CM; Smith, EJ; Grundy, D; Bountra, C;
British Journal of Pharmacology. 1998 123:U126-U126. doi:
PMID:

The sodium channel blocker 4030W92 inhibits deoxycholic acid-induced sensitisation of dorsal horn neurone responses to visceral and cutaneous mechanical stimulation in the anaesthetised rat
Kozlowski, CM; Smith, EJ; Grundy, D; Bountra, C;
British Journal of Pharmacology. 1998 123:U127-U127. doi:
PMID:

1997

Behavioural and electrophysiological evidence supporting a role for group I metabotropic glutamate receptors in the mediation of nociceptive inputs to the rat spinal cord.
Young, MR; Fleetwood-Walker, SM; Dickinson, T; Blackburn-Munro, G; Sparrow, H; Birch, PJ; Bountra, C;
Brain Research. 1997 777:161-169. doi:
PMID: 9449425

The effect of ibuprofen, morphine and amitriptyline on carrageenan-induced cutaneous hypersensitivity in the anaesthetised rat
Evans, KS; Scott, CM; Bountra, C;
British Journal of Pharmacology. 1997 122:P26-P26. doi:
PMID:

Effect of the neurokinin 1 (NK1) receptor antagonist GR205171 on adjuvant-induced inflammatory pain in the rat
Clayton, NM; Ward, P; Munglani, R; Keeling, S; Bountra, C;
British Journal of Pharmacology. 1997 122:P27-P27. doi:
PMID:

The effect of deoxycholic acid on dorsal horn responses to colorectal distension and cutaneous mechanical stimulation, and the effect of MK-801, in the anaesthetised rat
Kozlowski, CM; Grundy, D; Bountra, C;
British Journal of Pharmacology. 1997 122:P30-P30. doi:
PMID:

The neurokinin 1 (NK) receptor antagonist GR205171 reduces carrageenan-evoked Fos-like immunoreactivity in the rat lumbar spinal cord
Smith, EJ; Scott, CM; Bountra, C;
British Journal of Pharmacology. 1997 122:P75-P75. doi:
PMID:

Alosetron inhibits the colorectal distension-evoked depressor response and spinal c-Fos expression in the anaesthetised rat.
Scott, CM; Grundy, D; Boissonade, F; Bountra, C;
Gastroenterology. 1997 112:A822-A822. doi:
PMID:

Sensitisation of cutaneous afferent neurotransmission to innocuous and noxious mechanical stimuli using topical prostaglandin E(2) (PGE(2))
Evans, KS; Scott, CM; Bountra, C;
British Journal of Pharmacology. 1997 120:P218-P218. doi:
PMID:

Validation of the dual channel weight averager as an instrument of the measurement of clinically relevant pain
Clayton, NM; Oakley, I; Thompson, S; Wheeldon, A; Sargent, B; Bountra, C;
British Journal of Pharmacology. 1997 120:P219-P219. doi:
PMID:

The use of locomotor activity equipment to assess analgesic and anti-inflammatory activity
Thompson, SL; Clayton, NM; Oakley, IG; Bountra, C;
British Journal of Pharmacology. 1997 120:P220-P220. doi:
PMID:

The differential effects of fentanyl on dorsal horn neurones responsive to colorectal distension within the lumbosacral cord of the anaesthetised rat
Scott, CM; Grundy, D; Bountra, C;
British Journal of Pharmacology. 1997 120:P221-P221. doi:
PMID:

1996

Neuropeptide changes persist in spinal cord despite resolving hyperalgesia in a rat model of mononeuropathy.
Munglani, R; Harrison, SM; Smith, GD; Bountra, C; Birch, PJ; Elliot, PJ; Hunt, SP;
Brain Research. 1996 743:102-108. doi:
PMID: 9017236

Effects of post-injury MK-801 on behaviour and neuropeptides in the spinal cord dorsal horn of the mononeuropathic rat
Hudspith, MJ; Harrison, S; Smith, G; Elliot, PJ; Birch, PJ; Bountra, C; Jones, JG; Hunt, SP; Munglani, R;
British Journal of Anaesthesia. 1996 77:P691-P692. doi:
PMID:

Towards understanding the aetiology and pathophysiology of the emetic reflex: novel approaches to antiemetic drugs.
Bountra, C; Gale, JD; Gardner, CJ; Jordan, CC; Kilpatrick, GJ; Twissell, DJ; Ward, P;
Oncology: international journal of cancer research and treatment. 1996 53 Suppl 1:102-109. doi:
PMID: 8692545

1995

Discovery of an orally bioavailable NK<inf>1</inf> receptor antagonist, (2S,3S)-(2-methoxy-5-tetrazol-1-ylbenzyl)(2-phenylpiperidin-3-yl)amine (GR203040), with potent antiemetic activity
Ward, P; Armour, DR; Bays, DE; Evans, B; Giblin, GMP; Heron, N; Hubbard, T; Liang, K; Middlemiss, D; Mordaunt, J; Naylor, A; Pegg, NA; Vinader, MV; Watson, SP; Bountra, C; Evans, DC;
Journal of Medicinal Chemistry. 1995 38:4985-4992. doi:
PMID: 8544174

The broad-spectrum anti-emetic activity of the novel non-peptide tachykinin NK1 receptor antagonist GR203040.
Gardner, CJ; Twissell, DJ; Dale, TJ; Gale, JD; Jordan, CC; Kilpatrick, GJ; Bountra, C; Ward, P;
British Journal of Pharmacology. 1995 116:3158-3163. doi:
PMID: 8719790

THE ROLE OF NEUROKININ AND METABOTROPIC GLUTAMATE RECEPTORS IN THERMAL AND MECHANICAL PAW WITHDRAWAL RESPONSES IN NORMAL AND CARRAGEENAN-TREATED RATS
YOUNG, M; FLEETWOODWALKER, S; BIRCH, P; BOUNTRA, C; BOWERS, J;
British Journal of Pharmacology. 1995 114:P316-P316. doi:
PMID:

EFFECT OF DIFFERENT PREEMPTIVE TREATMENTS ON LONG-TERM NEUROPEPTIDE-EXPRESSION IN THE DORSAL-ROOT GANGLIA IN A MODEL OF NEUROPATHIC PAIN
MUNGLANI, R; HARRISSON, S; SMITH, G; BOUNTRA, C; BIRCH, P; JONES, J; HUNT, S;
British Journal of Anaesthesia. 1995 74:P482-P482. doi:
PMID:

1994

ANTIEMETIC ACTIVITY OF NEUROKININ NK1 RECEPTOR ANTAGONISTS IS MEDIATED CENTRALLY IN THE FERRET
GARDNER, C; BOUNTRA, C; BUNCE, K; DALE, T; JORDAN, C; TWISSELL, D; WARD, P;
British Journal of Pharmacology. 1994 112:U46-U46. doi:
PMID:

BACTERIAL LIPOPOLYSACCHARIDE INDUCES DE-NOVO SYNTHESIS OF CYCLOOXYGENASE ACTIVITY IN FRESHLY ISOLATED HUMAN MONONUCLEAR-CELLS
GROSSMAN, C; TREVETHICK, M; WISEMAN, J; BOUNTRA, C; BIRCH, P;
British Journal of Pharmacology. 1994 112:U219-U219. doi:
PMID:

1993

The vomiting reflex and the role of 5-HT3 receptors.
Freeman, AJ; Bountra, C; Dale, TJ; Gardner, CJ; Twissell, DJ;
Anti-Cancer Drugs: international journal on anti-cancer agents. 1993 4 Suppl 2:9-15. doi:
PMID: 7511008

Anti-emetic profile of a non-peptide neurokinin NK1 receptor antagonist, CP-99,994, in ferrets.
Bountra, C; Bunce, K; Dale, T; Gardner, C; Jordan, C; Twissell, D; Ward, P;
European Journal of Pharmacology. 1993 249:R3-R4. doi:
PMID: 7506663

ACETYLCHOLINE AND CHOLECYSTOKININ INDUCED ACID EXTRUSION IN MOUSE ISOLATED PANCREATIC ACINAR-CELLS AS MEASURED BY THE MICROPHYSIOMETER
DENYER, J; THORN, P; BOUNTRA, C; JORDAN, C;
The Journal of Physiology. 1993 459:P390-P390. doi:
PMID:

1992

Influence of extracellular and intracellular pH on GABA-gated chloride conductance in crayfish muscle fibres.
Pasternack, M; Bountra, C; Voipio, J; Kaila, K;
Neuroscience. 1992 47:921-929. doi:
PMID: 1374543

1991

Effect of extracellular pH on inhibitory postsynaptic potentials in guinea pig submucous neurones
Barajas-Lopez, C; Bountra, C; North, RA;
Journal of the Autonomic Nervous System. 1991 33:158-. doi: 10.1016/0165-1838(91)90180-B
PMID:

1990

Comparison of intracellular pH transients in single ventricular myocytes and isolated ventricular muscle of guinea-pig.
Bountra, C; Powell, T; Vaughan-Jones, RD;
The Journal of Physiology. 1990 424:343-365. doi:
PMID: 2167972

1989

Effect of intracellular and extracellular pH on contraction in isolated, mammalian cardiac muscle.
Bountra, C; Vaughan-Jones, RD;
The Journal of Physiology. 1989 418:163-187. doi:
PMID: 2621616

Sodium-hydrogen exchange and its role in controlling contractility during acidosis in cardiac muscle.
Vaughan-Jones, RD; Wu, ML; Bountra, C;
Molecular and Cellular Biochemistry: an international journal for chemical biology in health and disease. 1989 89:157-162. doi:
PMID: 2554122

1988

Mechanism of rate-dependent pH changes in the sheep cardiac Purkinje fibre.
Bountra, C; Kaila, K; Vaughan-Jones, RD;
The Journal of Physiology. 1988 406:483-501. doi:
PMID: 3254421

EXTRACELLULAR PH TRANSIENTS MEASURED WITH PHENOL RED AND PH-SELECTIVE MICROELECTRODES IN ISOLATED SHEEP CARDIAC PURKINJE-FIBERS
BOUNTRA, C; HILGEMANN, D; VAUGHANJONES, R;
The Journal of Physiology. 1988 406:P125-P125. doi:
PMID:

EFFECT OF INTRACELLULAR ACIDOSIS ON CONTRACTION IN MAMMALIAN CARDIAC-MUSCLE INVITRO
BOUNTRA, C; VAUGHANJONES, R;
The Journal of Physiology. 1988 407:P118-P118. doi:
PMID:

Effect of repetitive activity upon intracellular pH, sodium and contraction in sheep cardiac Purkinje fibres.
Bountra, C; Kaila, K; Vaughan-Jones, RD;
The Journal of Physiology. 1988 398:341-360. doi:
PMID: 3392677

1987

Single-channel currents from zona-free mouse eggs.
Bountra, C; Martin, RJ;
Quarterly journal of experimental physiology (Cambridge, England). 1987 72:483-492. doi:
PMID: 2447601

COMPARISON OF MICROELECTRODE MEASUREMENT OF INTRACELLULAR PH IN CARDIAC VENTRICULAR TISSUE AND ISOLATED VENTRICULAR CELLS OF GUINEA-PIG
BOUNTRA, C; POWELL, T; VAUGHANJONES, R;
The Journal of Physiology. 1987 390:P58-P58. doi:
PMID:

Regulation of intracellular pH in sheep cardiac Purkinje fibre: interactions among Na+, H+, and Ca2+1.
Kaila, K; Vaughan-Jones, RD; Bountra, C;
Canadian Journal of Physiology and Pharmacology. 1987 65:963-969. doi:
PMID: 3621056

The effect of lanthanum, quercetin and dinitrophenol on calcium-evoked electrical responses in hamster eggs.
Georgiou, P; Bountra, C; McNiven, A; House, CR;
Quarterly journal of experimental physiology (Cambridge, England). 1987 72:227-241. doi:
PMID: 2438714

Intracellular and whole-cell recordings from zona-free hamster eggs: significance of leak impalement artifact.
Georgiou, P; Bountra, C; House, CR;
Quarterly journal of experimental physiology (Cambridge, England). 1987 72:105-118. doi:
PMID: 3562774

THE INFLUENCE OF PHI ON TWITCH TENSION IN ISOLATED GUINEA-PIG PAPILLARY-MUSCLE
BOUNTRA, C; VAUGHANJONES, R;
The Journal of Physiology. 1987 382:P109-P109. doi:
PMID:

1986

A CA-ANTAGONIST INHIBITS THE INTRACELLULAR ACIDIFICATION OBSERVED DURING STIMULATION OF ISOLATED SHEEP CARDIAC PURKINJE-FIBERS
BOUNTRA, C; KAILA, K; VAUGHANJONES, R;
The Journal of Physiology. 1986 377:P114-P114. doi:
PMID:

1985

An electrophysiologic study of rabbit ciliary epithelium.
Green, K; Bountra, C; Georgiou, P; House, CR;
Investigative Ophthalmology and Visual Science. 1985 26:371-381. doi:
PMID: 3972518

1984

Calcium action potentials in unfertilized eggs of mice and hamsters.
Georgiou, P; Bountra, C; Bland, KP; House, CR;
Quarterly journal of experimental physiology (Cambridge, England). 1984 69:365-380. doi:
PMID: 6729022

SINGLE-CHANNEL CURRENTS IN UNFERTILIZED MOUSE EGGS
BLAND, K; BOUNTRA, C; GEORGIOU, P; HOUSE, C; MARTIN, R;
The Journal of Physiology. 1984 353:P84-P84. doi:
PMID:

MICRO-ELECTRODE RECORDINGS FROM RABBIT CILIARY EPITHELIUM INVITRO
BOUNTRA, C; GEORGIOU, P; GREEN, K; HOUSE, C;
The Journal of Physiology. 1984 354:P45-P45. doi:
PMID:

1983

Calcium-evoked opening of potassium channels in hamster eggs.
Georgiou, P; Bountra, C; Bland, KP; House, CR;
Quarterly journal of experimental physiology (Cambridge, England). 1983 68:687-700. doi:
PMID: 6316399

ACTION-POTENTIAL IN INFERTILIZED MOUSE EGG
BLAND, K; BOUNTRA, C; GEORGIOU, P; HOUSE, C;
The Journal of Physiology. 1983 343:P103-P103. doi:
PMID:

CALCIUM INJECTION INTO HAMSTER EGGS CAUSES HYPERPOLARIZATION AND DECREASE IN MEMBRANE RESISTANCE
BLAND, K; BOUNTRA, C; GEORGIOU, P; HOUSE, C;
The Journal of Physiology. 1983 342:P78-P79. doi:
PMID:

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