Susanne Müller-Knapp studied Human Biology in Marburg Germany followed by a PhD in molecular biology at the Karolinska Institute in Stockholm, Sweden (1997). She then had more than 6 years of postdoctoral training in the area of inflammation and gene regulation in Stockholm and at the DIBIT San Raffaele Scientific Institute in Milan, Italy working on working on the role of NFkB in inflammatory bowel disease and the function of the chromatin binding protein HMGB1 and its role in inflammation. In 2004 Susanne joined the SGC Oxford, where she worked first as External Research Manager and then Scientific Coordinator. She has been the Project Manager of the Epigenetic Probe Project, which creates tool compounds with defined specificity and selectivity for epigenetic targets and is heading the cell based assay group setting up cellular model systems to establish the efficacy and biological effect of the developed epigenetic inhibitors. She is now coordinating the kinase probe effort.
The Epigenetics and Cellular Biology group establishes cellular model systems to establish the efficacy of the developed inhibitors and then further uses them to increase the knowledge of the biological function of the targeted proteins as well as validate their role in disease as a target for pharmacological intervention. The generation of chemical probes is a major effort involving now eight pharmaceutical companies as well as a network of academic collaborators is also managed by my team. Apart from chemical probe development my group is also part of a European network “Affinomics” which aims to generate antibodies against 1000 targets involved in cancer.